
                                SEQUENCE LISTING

<110> Sirtris Pharmaceuticals

<120> SIRT1 POLYMORPHIC VARIANTS AND METHODS
  OF USE THEREOF

<130> SIRT045

<140> Not Yet Assigned    
<141> 2009-05-15  

<150> 61/127,716          
<151> 2008-05-15  

<160> 46

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4086
<212> DNA
<213> Human SIRT1 variant

<220> 
<221> misc_feature   
<222> 373
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 373
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 373
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 373
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 373
<223> n = A,T,C or G


<220> 
<221> misc_feature   
<222> 373
<223> n = A,T,C or G

<400> 1
gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aagatggcgg 60
acgaggcggc cctcgccctt cagcccggcg gctccccctc ggcggcgggg gccgacaggg 120
aggccgcgtc gtcccccgcc ggggagccgc tccgcaagag gccgcggaga gatggtcccg 180
gcctcgagcg gagcccgggc gagcccggtg gggcggcccc agagcgtgag gtgccggcgg 240
cggccagggg ctgcccgggt gcggcggcgg cggcgctgtg gcgggaggcg gaggcagagg 300
cggcggcggc aggcggggag caagaggccc aggcgactgc ggcggctggg gaaggagaca 360
atgggccggg ccngcagggc ccatctcggg agccaccgct ggccgacaac ttgtacgacg 420
aagacgacga cgacgagggc gaggaggagg aagaggcggc ggcggcggcg attgggtacc 480
gagataacct tctgttcggt gatgaaatta tcactaatgg ttttcattcc tgtgaaagtg 540
atgaggagga tagagcctca catgcaagct ctagtgactg gactccaagg ccacggatag 600
gtccatatac ttttgttcag caacatctta tgattggcac agatcctcga acaattctta 660
aagatttatt gccggaaaca atacctccac ctgagttgga tgatatgaca ctgtggcaga 720
ttgttattaa tatcctttca gaaccaccaa aaaggaaaaa aagaaaagat attaatacaa 780
ttgaagatgc tgtgaaatta ctgcaagagt gcaaaaaaat tatagttcta actggagctg 840
gggtgtctgt ttcatgtgga atacctgact tcaggtcaag ggatggtatt tatgctcgcc 900
ttgctgtaga cttcccagat cttccagatc ctcaagcgat gtttgatatt gaatatttca 960
gaaaagatcc aagaccattc ttcaagtttg caaaggaaat atatcctgga caattccagc 1020
catctctctg tcacaaattc atagccttgt cagataagga aggaaaacta cttcgcaact 1080
atacccagaa catagacacg ctggaacagg ttgcgggaat ccaaaggata attcagtgtc 1140
atggttcctt tgcaacagca tcttgcctga tttgtaaata caaagttgac tgtgaagctg 1200
tacgaggaga tatttttaat caggtagttc ctcgatgtcc taggtgccca gctgatgaac 1260
cgcttgctat catgaaacca gagattgtgt tttttggtga aaatttacca gaacagtttc 1320
atagagccat gaagtatgac aaagatgaag ttgacctcct cattgttatt gggtcttccc 1380
tcaaagtaag accagtagca ctaattccaa gttccatacc ccatgaagtg cctcagatat 1440
taattaatag agaacctttg cctcatctgc attttgatgt agagcttctt ggagactgtg 1500
atgtcataat taatgaattg tgtcataggt taggtggtga atatgccaaa ctttgctgta 1560
accctgtaaa gctttcagaa attactgaaa aacctccacg aacacaaaaa gaattggctt 1620
atttgtcaga gttgccaccc acacctcttc atgtttcaga agactcaagt tcaccagaaa 1680
gaacttcacc accagattct tcagtgattg tcacactttt agaccaagca gctaagagta 1740
atgatgattt agatgtgtct gaatcaaaag gttgtatgga agaaaaacca caggaagtac 1800
aaacttctag gaatgttgaa agtattgctg aacagatgga aaatccggat ttgaagaatg 1860
ttggttctag tactggggag aaaaatgaaa gaacttcagt ggctggaaca gtgagaaaat 1920
gctggcctaa tagagtggca aaggagcaga ttagtaggcg gcttgatggt aatcagtatc 1980
tgtttttgcc accaaatcgt tacattttcc atggcgctga ggtatattca gactctgaag 2040
atgacgtctt atcctctagt tcttgtggca gtaacagtga tagtgggaca tgccagagtc 2100
caagtttaga agaacccatg gaggatgaaa gtgaaattga agaattctac aatggcttag 2160
aagatgagcc tgatgttcca gagagagctg gaggagctgg atttgggact gatggagatg 2220
atcaagaggc aattaatgaa gctatatctg tgaaacagga agtaacagac atgaactatc 2280
catcaaacaa atcatagtgt aataattgtg caggtacagg aattgttcca ccagcattag 2340
gaactttagc atgtcaaaat gaatgtttac ttgtgaactc gatagagcaa ggaaaccaga 2400
aaggtgtaat atttataggt tggtaaaata gattgttttt catggataat ttttaacttc 2460
attatttctg tacttgtaca aactcaacac taactttttt ttttttaaaa aaaaaaaggt 2520
actaagtatc ttcaatcagc tgttgggtca agactaactt tcttttaaag gttcatttgt 2580
atgataaatt catatgtgta tatataattt tttttgtttt gtctagtgag tttcaacatt 2640
tttaaagttt tcaaaaagcc atcggaatgt taaattaatg taaagggaca gctaatctag 2700
accaaagaat ggtattttca cttttctttg taacattgaa tggtttgaag tactcaaaat 2760
ctgttacgct aaacttttga ttctttaaca caattatttt taaacactgg cattttccaa 2820
aactgtggca gctaactttt taaaatctca aatgacatgc agtgtgagta gaaggaagtc 2880
aacaatatgt ggggagagca ctcggttgtc tttactttta aaagtaatac ttggtgctaa 2940
gaatttcagg attattgtat ttacgttcaa atgaagatgg cttttgtact tcctgtggac 3000
atgtagtaat gtctatattg gctcataaaa ctaacctgaa aaacaaataa atgctttgga 3060
aatgtttcag ttgctttaga aacattagtg cctgcctgga tccccttagt tttgaaatat 3120
ttgccattgt tgtttaaata cctatcactg tggtagagct tgcattgatc ttttccacaa 3180
gtattaaact gccaaaatgt gaatatgcaa agcctttctg aatctataat aatggtactt 3240
ctactgggga gagtgtaata ttttggactg ctgttttcca ttaatgagga gagcaacagg 3300
cccctgatta tacagttcca aagtaataag atgttaattg taattcagcc agaaagtaca 3360
tgtctcccat tgggaggatt tggtgttaaa taccaaactg ctagccctag tattatggag 3420
atgaacatga tgatgtaact tgtaatagca gaatagttaa tgaatgaaac tagttcttat 3480
aatttatctt tatttaaaag cttagcctgc cttaaaacta gagatcaact ttctcagctg 3540
caaaagcttc tagtctttca agaagttcat actttatgaa attgcacagt aagcatttat 3600
ttttcagacc atttttgaac atcactccta aattaataaa gtattcctct gttgctttag 3660
tatttattac aataaaaagg gtttgaaata tagctgttct ttatgcataa aacacccagc 3720
taggaccatt actgccagag aaaaaaatcg tattgaatgg ccatttccct acttataaga 3780
tgtctcaatc tgaatttatt tggctacact aaagaatgca gtatatttag ttttccattt 3840
gcatgatgtt tgtgtgctat agatgatatt ttaaattgaa aagtttgttt taaattattt 3900
ttacagtgaa gactgttttc agctcttttt atattgtaca tagtctttta tgtaatttac 3960
tggcatatgt tttgtagact gtttaatgac tggatatctt ccttcaactt ttgaaataca 4020
aaaccagtgt tttttacttg tacactgttt taaagtctat taaaattgtc atttgacttt 4080
tttctg                                                            4086

<210> 2
<211> 747
<212> PRT
<213> Human SIRT1 variant

<220> 
<221> VARIANT        
<222> 107
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 107
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 107
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 107
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 107
<223> Xaa = Any Amino Acid


<220> 
<221> VARIANT        
<222> 107
<223> Xaa = Any Amino Acid

<400> 2
Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser
 1               5                  10                  15      
Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro
            20                  25                  30          
Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro
        35                  40                  45              
Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala
    50                  55                  60                  
Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala
                85                  90                  95      
Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Xaa Gln Gly Pro Ser Arg
            100                 105                 110         
Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu
        115                 120                 125             
Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp
    130                 135                 140                 
Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys
145                 150                 155                 160 
Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp
                165                 170                 175     
Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu
            180                 185                 190         
Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu
        195                 200                 205             
Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val
    210                 215                 220                 
Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile
225                 230                 235                 240 
Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile
                245                 250                 255     
Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp
            260                 265                 270         
Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro
        275                 280                 285             
Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys
    290                 295                 300                 
Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln
305                 310                 315                 320 
Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu
                325                 330                 335     
Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln
            340                 345                 350         
Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr
        355                 360                 365             
Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg
    370                 375                 380                 
Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala
385                 390                 395                 400 
Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu
                405                 410                 415     
Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu
            420                 425                 430         
Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val
        435                 440                 445             
Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile
    450                 455                 460                 
Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly
465                 470                 475                 480 
Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu
                485                 490                 495     
Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu
            500                 505                 510         
Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro
        515                 520                 525             
Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr
    530                 535                 540                 
Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala
545                 550                 555                 560 
Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu
                565                 570                 575     
Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala
            580                 585                 590         
Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly
        595                 600                 605             
Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp
    610                 615                 620                 
Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn
625                 630                 635                 640 
Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu
                645                 650                 655     
Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly
            660                 665                 670         
Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro
        675                 680                 685             
Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp
    690                 695                 700                 
Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp
705                 710                 715                 720 
Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu
                725                 730                 735     
Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser
            740                 745         


<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide substrate for the SIRT1 enzyme

<220> 
<221> ACETYLATION    
<222> (1)...(1)

<220> 
<221> ACETYLATION    
<222> (12)...(12)

<220> 
<221> MOD_RES        
<222> (13)...(13)
<223> Nle

<400> 3
Glu Glu Lys Gly Gln Ser Thr Ser Ser His Ser Lys Leu Ser Thr Glu
 1               5                  10                  15      
Gly Lys Glu Glu
            20  


<210> 4
<211> 23
<212> DNA
<213> PCR primer

<400> 4
gcgggagcag aggaggcgag gga                                         23

<210> 5
<211> 23
<212> DNA
<213> PCR Primer

<400> 5
gggccggggt ggggagggga acg                                         23

<210> 6
<211> 23
<212> DNA
<213> PCR primer

<400> 6
ggcagttgga agatggcgga cga                                         23

<210> 7
<211> 23
<212> DNA
<213> PCR primer

<400> 7
ggagcaagag gcccaggcga ctg                                         23

<210> 8
<211> 23
<212> DNA
<213> PCR primer

<400> 8
gtacccaatc gccgccgccg ccg                                         23

<210> 9
<211> 23
<212> DNA
<213> PCR primer

<400> 9
acacacgccg tgtaaatgtt aaa                                         23

<210> 10
<211> 23
<212> DNA
<213> PCR primer

<400> 10
cggatcacct gaggtcggga gtt                                         23

<210> 11
<211> 23
<212> DNA
<213> PCR primer

<400> 11
gccgtgtaaa tgttaaatgc tgt                                         23

<210> 12
<211> 23
<212> DNA
<213> PCR primer

<400> 12
actccagcct ccgcaacaag agc                                         23

<210> 13
<211> 23
<212> DNA
<213> PCR primer

<400> 13
gtcttcccaa ctcttcatta gat                                         23

<210> 14
<211> 23
<212> DNA
<213> PCR primer

<400> 14
agttcccaaa catccattat cat                                         23

<210> 15
<211> 23
<212> DNA
<213> PCR primer

<400> 15
cttaaagatt tattgccgga aac                                         23

<210> 16
<211> 22
<212> DNA
<213> PCR primer

<400> 16
gtttccggca ataaatctta ag                                          22

<210> 17
<211> 23
<212> DNA
<213> PCR primer

<400> 17
ctgaaataag ggtagggttg tat                                         23

<210> 18
<211> 23
<212> DNA
<213> PCR primer

<400> 18
atcttactcc gccacagtag cag                                         23

<210> 19
<211> 23
<212> DNA
<213> PCR primer

<400> 19
gatggtattt atgctcgcct tgc                                         23

<210> 20
<211> 22
<212> DNA
<213> PCR primer

<400> 20
ttactccgcc acagtgcagc at                                          22

<210> 21
<211> 23
<212> DNA
<213> PCR primer

<400> 21
agtctacagc aaggcgagca taa                                         23

<210> 22
<211> 23
<212> DNA
<213> PCR primer

<400> 22
agagatgttt atgggccgac ttt                                         23

<210> 23
<211> 23
<212> DNA
<213> PCR primer

<400> 23
ttaactgtca aggccaatac ttc                                         23

<210> 24
<211> 23
<212> DNA
<213> PCR primer

<400> 24
cctttggatt cccgcaacct gtt                                         23

<210> 25
<211> 23
<212> DNA
<213> PCR primer

<400> 25
aacaggttgc gggaatccaa agg                                         23

<210> 26
<211> 22
<212> DNA
<213> PCR primer

<400> 26
caaaacaaaa atccttaaac cc                                          22

<210> 27
<211> 23
<212> DNA
<213> PCR primer

<400> 27
acattttatg ttcggcttag ata                                         23

<210> 28
<211> 23
<212> DNA
<213> PCR primer

<400> 28
aaagttgact gtgaagctgt acg                                         23

<210> 29
<211> 23
<212> DNA
<213> PCR primer

<400> 29
cgtacagctt cacagtcaac ttt                                         23

<210> 30
<211> 23
<212> DNA
<213> PCR primer

<400> 30
gactatttct aacttgggct tac                                         23

<210> 31
<211> 23
<212> DNA
<213> PCR primer

<400> 31
gtctattata cagacccaca acc                                         23

<210> 32
<211> 23
<212> DNA
<213> PCR primer

<400> 32
gggcttactc tttgcttctc tac                                         23

<210> 33
<211> 23
<212> DNA
<213> PCR primer

<400> 33
tatagaaatg ttctccaaaa acc                                         23

<210> 34
<211> 23
<212> DNA
<213> PCR primer

<400> 34
cccttgttgg atttttgcat aat                                         23

<210> 35
<211> 23
<212> DNA
<213> PCR primer

<400> 35
aatcaactac ataaagctac cct                                         23

<210> 36
<211> 23
<212> DNA
<213> PCR primer

<400> 36
ttatttttca ccctatttag gtt                                         23

<210> 37
<211> 23
<212> DNA
<213> PCR primer

<400> 37
cgattaacct gccgaaatag cta                                         23

<210> 38
<211> 23
<212> DNA
<213> PCR primer

<400> 38
gaaccaacat tcttcaaatc cgg                                         23

<210> 39
<211> 23
<212> DNA
<213> PCR primer

<400> 39
aaggcagagc tggaacccac act                                         23

<210> 40
<211> 23
<212> DNA
<213> PCR primer

<400> 40
ccaacagctg attgaagata ctt                                         23

<210> 41
<211> 23
<212> DNA
<213> PCR primer

<400> 41
tgccagagtc caagtttaga aga                                         23

<210> 42
<211> 23
<212> DNA
<213> PCR primer

<400> 42
tcttctaaac ttggactctg gca                                         23

<210> 43
<211> 430
<212> DNA
<213> Homo sapien

<220> 
<221> CDS            
<222> (1)...(430)

<400> 43
atg gcg gac gag gcg gcc ctc gcc ctt cag ccc ggc ggc tcc ccc tcg   48
Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser
 1               5                   10                  15
 
gcg gcg ggg gcc gac agg gag gcc gcg tcg tcc ccc gcc ggg gag ccg   96
Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro
             20                  25                  30
 
ctc cgc aag agg ccg cgg aga gat ggt ccc ggc ctc gag cgg agc ccg   144
Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro
         35                  40                  45
 
ggc gag ccc ggt ggg gcg gcc cca gag cgt gag gtg ccg gcg gcg gcc   192
Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala
     50                  55                  60
 
agg ggc tgc ccg ggt gcg gcg gcg gcg gcg ctg tgg cgg gag gcg gag   240
Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu
 65                  70                  75                  80
 
gca gag gcg gcg gcg gca ggc ggg gag caa gag gcc cag gcg act gcg   288
Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala
                 85                  90                  95
 
gcg gct ggg gaa gga gac aat ggg ccg ggc ccg cag ggc cca tct cgg   336
Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Pro Gln Gly Pro Ser Arg
            100                 105                 110
 
gag cca ccg ctg gcc gac aac ttg tac gac gaa gac gac gac gac gag   384
Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu
        115                 120                 125
 
ggc gag gag gag gaa gag gcg gcg gcg gcg gcg att ggg tac cga g     430
Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg
    130                 135                 140
 


<210> 44
<211> 143
<212> PRT
<213> Homo sapien

<400> 44
Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser
 1               5                  10                  15      
Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro
            20                  25                  30          
Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro
        35                  40                  45              
Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala
    50                  55                  60                  
Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala
                85                  90                  95      
Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Pro Gln Gly Pro Ser Arg
            100                 105                 110         
Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu
        115                 120                 125             
Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg
    130                 135                 140             


<210> 45
<211> 430
<212> DNA
<213> Homo sapien

<220> 
<221> CDS            
<222> (1)...(430)

<400> 45
atg gcg gac gag gcg gcc ctc gcc ctt cag ccc ggc ggc tcc ccc tcg   48
Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser
 1               5                   10                  15
 
gcg gcg ggg gcc gac agg gag gcc gcg tcg tcc ccc gcc ggg gag ccg   96
Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro
             20                  25                  30
 
ctc cgc aag agg ccg cgg aga gat ggt ccc ggc ctc gag cgg agc ccg   144
Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro
         35                  40                  45
 
ggc gag ccc ggt ggg gcg gcc cca gag cgt gag gtg ccg gcg gcg gcc   192
Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala
     50                  55                  60
 
agg ggc tgc ccg ggt gcg gcg gcg gcg gcg ctg tgg cgg gag gcg gag   240
Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu
 65                  70                  75                  80
 
gca gag gcg gcg gcg gca ggc ggg gag caa gag gcc cag gcg act gcg   288
Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala
                 85                  90                  95
 
gcg gct ggg gaa gga gac aat ggg ccg ggc ctg cag ggc cca tct cgg   336
Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg
            100                 105                 110
 
gag cca ccg ctg gcc gac aac ttg tac gac gaa gac gac gac gac gag   384
Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu
        115                 120                 125
 
ggc gag gag gag gaa gag gcg gcg gcg gcg gcg att ggg tac cga g     430
Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg
    130                 135                 140
 


<210> 46
<211> 143
<212> PRT
<213> Homo sapien

<400> 46
Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser
 1               5                  10                  15      
Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro
            20                  25                  30          
Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro
        35                  40                  45              
Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala
    50                  55                  60                  
Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala
                85                  90                  95      
Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg
            100                 105                 110         
Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu
        115                 120                 125             
Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg
    130                 135                 140             

