                         SEQUENCE LISTING

<110>  Assistance Publique-Hpitaux de Paris
 
<120>  A method for predicting clinical outcome of patients with 
       non-small cell lung carcinoma

<130>  B741

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  3572
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (312)..(3038)

<400>  1
gaataattct gctacaaggc tgatttcaag gacatgaatt gttgacctca tcccaacatc     60

agaacctcag atgttctaat ttttgcacca ttccaggcaa gttgatctta taaggaaata    120

aaattgaacc ttaggggtct gatggaaatt cactgtgaca ttcaaatcaa gaaaacttgc    180

taatgcccac agagcctttt ccccatgggc cctgatggta gcctccagaa ggtgcagcct    240

caggtggtgc cctttcttct gtggcaagaa taaactttgg gtcttggatt gcaataccac    300

ctgtggagaa a atg gta tgc gag gga aag cga tca gcc tct tgc cct tgt     350
             Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys        
             1               5                   10                     

ttc ttc ctc ttg acc gcc aag ttc tac tgg atc ctc aca atg atg caa      398
Phe Phe Leu Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln         
    15                  20                  25                          

aga act cac agc cag gag tat gcc cat tcc ata cgg gtg gat ggg gac      446
Arg Thr His Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp         
30                  35                  40                  45          

att att ttg ggg ggt ctc ttc cct gtc cac gca aag gga gag aga ggg      494
Ile Ile Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly         
                50                  55                  60              

gtg cct tgt ggg gag ctg aag aag gaa aag ggg att cac aga ctg gag      542
Val Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu         
            65                  70                  75                  

gcc atg ctt tat gca att gac cag att aac aag gac cct gat ctc ctt      590
Ala Met Leu Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu         
        80                  85                  90                      

tcc aac atc act ctg ggt gtc cgc atc ctc gac acg tgc tct agg gac      638
Ser Asn Ile Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp         
    95                  100                 105                         

acc tat gct ttg gag cag tct cta aca ttc gtg cag gca tta ata gag      686
Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu         
110                 115                 120                 125         

aaa gat gct tcg gat gtg aag tgt gct aat gga gat cca ccc att ttc      734
Lys Asp Ala Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe         
                130                 135                 140             

acc aag ccc gac aag att tct ggc gtc ata ggt gct gca gca agc tcc      782
Thr Lys Pro Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser         
            145                 150                 155                 

gtg tcc atc atg gtt gct aac att tta aga ctt ttt aag ata cct caa      830
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln         
        160                 165                 170                     

atc agc tat gca tcc aca gcc cca gag cta agt gat aac acc agg tat      878
Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr         
    175                 180                 185                         

gac ttt ttc tct cga gtg gtt ccg cct gac tcc tac caa gcc caa gcc      926
Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala         
190                 195                 200                 205         

atg gtg gac atc gtg aca gca ctg gga tgg aat tat gtt tcg aca ctg      974
Met Val Asp Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu         
                210                 215                 220             

gct tct gag ggg aac tat ggt gag agc ggt gtg gag gcc ttc acc cag     1022
Ala Ser Glu Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln         
            225                 230                 235                 

atc tcg agg gag att ggt ggt gtt tgc att gct cag tca cag aaa atc     1070
Ile Ser Arg Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile         
        240                 245                 250                     

cca cgt gaa cca aga cct gga gaa ttt gaa aaa att atc aaa cgc ctg     1118
Pro Arg Glu Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu         
    255                 260                 265                         

cta gaa aca cct aat gct cga gca gtg att atg ttt gcc aat gag gat     1166
Leu Glu Thr Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp         
270                 275                 280                 285         

gac atc agg agg ata ttg gaa gca gca aaa aaa cta aac caa agt ggg     1214
Asp Ile Arg Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly         
                290                 295                 300             

cat ttt ctc tgg att ggc tca gat agt tgg gga tcc aaa ata gca cct     1262
His Phe Leu Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro         
            305                 310                 315                 

gtc tat cag caa gag gag att gca gaa ggg gct gtg aca att ttg ccc     1310
Val Tyr Gln Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro         
        320                 325                 330                     

aaa cga gca tca att gat gga ttt gat cga tac ttt aga agc cga act     1358
Lys Arg Ala Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr         
    335                 340                 345                         

ctt gcc aat aat cga aga aat gtg tgg ttt gca gaa ttc tgg gag gag     1406
Leu Ala Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu         
350                 355                 360                 365         

aat ttt ggc tgc aag tta gga tca cat ggg aaa agg aac agt cat ata     1454
Asn Phe Gly Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile         
                370                 375                 380             

aag aaa tgc aca ggg ctg gag cga att gct cgg gat tca tct tat gaa     1502
Lys Lys Cys Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu         
            385                 390                 395                 

cag gaa gga aag gtc caa ttt gta att gat gct gta tat tcc atg gct     1550
Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala         
        400                 405                 410                     

tac gcc ctg cac aat atg cac aaa gat ctc tgc cct gga tac att ggc     1598
Tyr Ala Leu His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly         
    415                 420                 425                         

ctt tgt cca cga atg agt acc att gat ggg aaa gag cta ctt ggt tat     1646
Leu Cys Pro Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr         
430                 435                 440                 445         

att cgg gct gta aat ttt aat ggc agt gct ggc act cct gtc act ttt     1694
Ile Arg Ala Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe         
                450                 455                 460             

aat gaa aac gga gat gct cct gga cgt tat gat atc ttc cag tat caa     1742
Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln         
            465                 470                 475                 

ata acc aac aaa agc aca gag tac aaa gtc atc ggc cac tgg acc aat     1790
Ile Thr Asn Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn         
        480                 485                 490                     

cag ctt cat cta aaa gtg gaa gac atg cag tgg gct cat aga gaa cat     1838
Gln Leu His Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His         
    495                 500                 505                         

act cac ccg gcg tct gtc tgc agc ctg ccg tgt aag cca ggg gag agg     1886
Thr His Pro Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg         
510                 515                 520                 525         

aag aaa acg gtg aaa ggg gtc cct tgc tgc tgg cac tgt gaa cgc tgt     1934
Lys Lys Thr Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys         
                530                 535                 540             

gaa ggt tac aac tac cag gtg gat gag ctg tcc tgt gaa ctt tgc cct     1982
Glu Gly Tyr Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro         
            545                 550                 555                 

ctg gat cag aga ccc aac atg aac cgc aca ggc tgc cag ctt atc ccc     2030
Leu Asp Gln Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro         
        560                 565                 570                     

atc atc aaa ttg gag tgg cat tct ccc tgg gct gtg gtg cct gtg ttt     2078
Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe         
    575                 580                 585                         

gtt gca ata ttg gga atc atc gcc acc acc ttt gtg atc gtg acc ttt     2126
Val Ala Ile Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe         
590                 595                 600                 605         

gtc cgc tat aat gac aca cct atc gtg agg gct tca gga cgc gaa ctt     2174
Val Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu         
                610                 615                 620             

agt tac gtg ctc cta acg ggg att ttt ctc tgt tat tca atc acg ttt     2222
Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe         
            625                 630                 635                 

tta atg att gca gca cca gat aca atc ata tgc tcc ttc cga cgg gtc     2270
Leu Met Ile Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val         
        640                 645                 650                     

ttc cta gga ctt ggc atg tgt ttc agc tat gca gcc ctt ctg acc aaa     2318
Phe Leu Gly Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys         
    655                 660                 665                         

aca aac cgt atc cac cga ata ttt gag cag ggg aag aaa tct gtc aca     2366
Thr Asn Arg Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr         
670                 675                 680                 685         

gcg ccc aag ttc att agt cca gca tct cag ctg gtg atc acc ttc agc     2414
Ala Pro Lys Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser         
                690                 695                 700             

ctc atc tcc gtc cag ctc ctt gga gtg ttt gtc tgg ttt gtt gtg gat     2462
Leu Ile Ser Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp         
            705                 710                 715                 

ccc ccc cac atc atc att gac tat gga gag cag cgg aca cta gat cca     2510
Pro Pro His Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro         
        720                 725                 730                     

gag aag gcc agg gga gtg ctc aag tgt gac att tct gat ctc tca ctc     2558
Glu Lys Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu         
    735                 740                 745                         

att tgt tca ctt gga tac agt atc ctc ttg atg gtc act tgt act gtt     2606
Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val         
750                 755                 760                 765         

tat gcc att aaa acg aga ggt gtc cca gag act ttc aat gaa gcc aaa     2654
Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys         
                770                 775                 780             

cct att gga ttt acc atg tat acc acc tgc atc att tgg tta gct ttc     2702
Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe         
            785                 790                 795                 

atc ccc atc ttt ttt ggt aca gcc cag tca gca gaa aag atg tac atc     2750
Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile         
        800                 805                 810                     

cag aca aca aca ctt act gtc tcc atg agt tta agt gct tca gta tct     2798
Gln Thr Thr Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser         
    815                 820                 825                         

ctg ggc atg ctc tat atg ccc aag gtt tat att ata att ttt cat cca     2846
Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro         
830                 835                 840                 845         

gaa cag aat gtt caa aaa cgc aag agg agc ttc aag gct gtg gtg aca     2894
Glu Gln Asn Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr         
                850                 855                 860             

gct gcc acc atg caa agc aaa ctg atc caa aaa gga aat gac aga cca     2942
Ala Ala Thr Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro         
            865                 870                 875                 

aat ggc gag gtg aaa agt gaa ctc tgt gag agt ctt gaa acc aac act     2990
Asn Gly Glu Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr         
        880                 885                 890                     

tcc tct acc aag aca aca tat atc agt tac agc aat cat tca atc tga     3038
Ser Ser Thr Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile             
    895                 900                 905                         

aacagggaaa tggcacaatc tgaagagatg tggtatatga tcttaaatga tgaacatgag   3098

accgcaaaaa ttcactcctg gagatctccg tagactacaa tcaatcaaat caatagtcag   3158

tcttgtaagg aacaaaaatt agccatgagc caaaagtatc aataaacggg gagtgaagaa   3218

acccgtttta tacaataaaa ccaatgagtg tcaagctaaa gtattgctta ttcatgagca   3278

gttaaaacaa atcacaaaag gaaaactaat gttagctcgt gaaaaaaaat gctgttgaaa   3338

taaataatgt ctgatgttat tcttgtattt ttctgtgatt gtgagaactc ccgttcctgt   3398

cccacattgt ttaacttgta taagacaatg agtctgtttc ttgtaatggc tgaccagatt   3458

gaagccctgg gttgtgctaa aaataaatgc aatgattgat gcatgcaatt ttttatacaa   3518

ataatttatt tctaataata aaggaatgtt ttgcaaatgt taaaaaaaaa aaaa         3572


<210>  2
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr Ser Ser Thr 
                885                 890                 895     


Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile 
            900                 905             


<210>  3
<211>  3540
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (118)..(1629)

<400>  3
ggcggcagaa gcggcagcgc tcgccattgc cgctggtggc aggaggctgc gaggagccgg     60

cgcggtcgca gtctccacgg cgcaggccca cggtagcgca gccgctctga gaacttc       117

atg gag gaa cac gga gtg acc caa acc gaa cat atg gct acc ata gaa      165
Met Glu Glu His Gly Val Thr Gln Thr Glu His Met Ala Thr Ile Glu         
1               5                   10                  15              

gca cat gca gtg gcc cag caa gtg cag cag gtc cat gtg gct act tac      213
Ala His Ala Val Ala Gln Gln Val Gln Gln Val His Val Ala Thr Tyr         
            20                  25                  30                  

acc gag cat agt atg ctg agt gct gat gaa gac tcg cct tct tct ccc      261
Thr Glu His Ser Met Leu Ser Ala Asp Glu Asp Ser Pro Ser Ser Pro         
        35                  40                  45                      

gag gac acc tct tac gat gac tca gat ata ctc aac tcc aca gca gct      309
Glu Asp Thr Ser Tyr Asp Asp Ser Asp Ile Leu Asn Ser Thr Ala Ala         
    50                  55                  60                          

gat gag gtg aca gct cat ctg gca gct gca ggt cct gtg gga atg gcc      357
Asp Glu Val Thr Ala His Leu Ala Ala Ala Gly Pro Val Gly Met Ala         
65                  70                  75                  80          

gct gct gct gct gtg gca aca gga aag aaa cgg aaa cgg cct cat gta      405
Ala Ala Ala Ala Val Ala Thr Gly Lys Lys Arg Lys Arg Pro His Val         
                85                  90                  95              

ttt gag tct aat cca tct atc cgg aag agg caa caa aca cgt ttg ctt      453
Phe Glu Ser Asn Pro Ser Ile Arg Lys Arg Gln Gln Thr Arg Leu Leu         
            100                 105                 110                 

cgg aaa ctt cga gcc acg tta gat gaa tat act act cgt gtg gga cag      501
Arg Lys Leu Arg Ala Thr Leu Asp Glu Tyr Thr Thr Arg Val Gly Gln         
        115                 120                 125                     

caa gct att gtc ctc tgt atc tca ccc tcc aaa cct aac cct gtc ttt      549
Gln Ala Ile Val Leu Cys Ile Ser Pro Ser Lys Pro Asn Pro Val Phe         
    130                 135                 140                         

aaa gtg ttt ggt gca gca cct ttg gag aat gtg gtg cgt aag tac aag      597
Lys Val Phe Gly Ala Ala Pro Leu Glu Asn Val Val Arg Lys Tyr Lys         
145                 150                 155                 160         

agc atg atc ctg gaa gac ctg gag tct gct ctg gca gaa cac gcc cct      645
Ser Met Ile Leu Glu Asp Leu Glu Ser Ala Leu Ala Glu His Ala Pro         
                165                 170                 175             

gcg cca cag gag gtt aac tca gaa ctg ccg cct ctc acc atc gac gga      693
Ala Pro Gln Glu Val Asn Ser Glu Leu Pro Pro Leu Thr Ile Asp Gly         
            180                 185                 190                 

att cca gtc tct gtg gac aaa atg acc cag gcc cag ctt cgg gca ttt      741
Ile Pro Val Ser Val Asp Lys Met Thr Gln Ala Gln Leu Arg Ala Phe         
        195                 200                 205                     

atc cca gag atg ctc aag tac tct aca ggt cgg gga aaa cca ggc tgg      789
Ile Pro Glu Met Leu Lys Tyr Ser Thr Gly Arg Gly Lys Pro Gly Trp         
    210                 215                 220                         

ggg aaa gaa agc tgc aag ccc atc tgg tgg cct gaa gat atc ccc tgg      837
Gly Lys Glu Ser Cys Lys Pro Ile Trp Trp Pro Glu Asp Ile Pro Trp         
225                 230                 235                 240         

gca aat gtc cgg agt gat gtc cgc aca gaa gag caa aag cag agg gtt      885
Ala Asn Val Arg Ser Asp Val Arg Thr Glu Glu Gln Lys Gln Arg Val         
                245                 250                 255             

tca tgg acc cag gca cta cgg acc ata gtt aaa aac tgt tat aaa cag      933
Ser Trp Thr Gln Ala Leu Arg Thr Ile Val Lys Asn Cys Tyr Lys Gln         
            260                 265                 270                 

cat ggg cgg gaa gac ctt ttg tat gcc ttt gaa gat cag caa acg caa      981
His Gly Arg Glu Asp Leu Leu Tyr Ala Phe Glu Asp Gln Gln Thr Gln         
        275                 280                 285                     

aca cag gcc aca gcc aca cat agt ata gct cat ctt gta cca tca cag     1029
Thr Gln Ala Thr Ala Thr His Ser Ile Ala His Leu Val Pro Ser Gln         
    290                 295                 300                         

act gta gtc cag act ttt agt aac cct gat ggc act gtc tca ctt atc     1077
Thr Val Val Gln Thr Phe Ser Asn Pro Asp Gly Thr Val Ser Leu Ile         
305                 310                 315                 320         

cag gtt ggt acg ggg gca aca gta gcc aca ttg gct gat gct tca gaa     1125
Gln Val Gly Thr Gly Ala Thr Val Ala Thr Leu Ala Asp Ala Ser Glu         
                325                 330                 335             

ttg cca acc acg gtc acc gtt gcc caa gtg aat tat tct gcc gtg gct     1173
Leu Pro Thr Thr Val Thr Val Ala Gln Val Asn Tyr Ser Ala Val Ala         
            340                 345                 350                 

gat gga gag gtg gaa caa aat tgg gcc acg tta cag gga ggt gag atg     1221
Asp Gly Glu Val Glu Gln Asn Trp Ala Thr Leu Gln Gly Gly Glu Met         
        355                 360                 365                     

acc atc cag acg acg caa gca tca gag gcc acc cag gcg gtg gca tcg     1269
Thr Ile Gln Thr Thr Gln Ala Ser Glu Ala Thr Gln Ala Val Ala Ser         
    370                 375                 380                         

ttg gca gag gcc gca gtg gca gct tct cag gag atg cag cag gga gct     1317
Leu Ala Glu Ala Ala Val Ala Ala Ser Gln Glu Met Gln Gln Gly Ala         
385                 390                 395                 400         

aca gtc act atg gcg ctt aac agc gaa gct gcc gcc cat gct gtc gcc     1365
Thr Val Thr Met Ala Leu Asn Ser Glu Ala Ala Ala His Ala Val Ala         
                405                 410                 415             

acc ctg gct gag gcc acc tta caa ggt ggg gga cag atc gtc ttg tct     1413
Thr Leu Ala Glu Ala Thr Leu Gln Gly Gly Gly Gln Ile Val Leu Ser         
            420                 425                 430                 

ggg gaa acc gca gca gcc gtc gga gca ctt act gga gtc caa gat gct     1461
Gly Glu Thr Ala Ala Ala Val Gly Ala Leu Thr Gly Val Gln Asp Ala         
        435                 440                 445                     

aat ggc ctg gtc cag atc cct gtg agc atg tac cag act gtg gtg acc     1509
Asn Gly Leu Val Gln Ile Pro Val Ser Met Tyr Gln Thr Val Val Thr         
    450                 455                 460                         

agc ctc gcc cag ggc aac gga cca gtg cag gtg gcc atg gcc cct gtg     1557
Ser Leu Ala Gln Gly Asn Gly Pro Val Gln Val Ala Met Ala Pro Val         
465                 470                 475                 480         

acc acc agg ata tca gac agc gca gtc acc atg gac ggc caa gct gtg     1605
Thr Thr Arg Ile Ser Asp Ser Ala Val Thr Met Asp Gly Gln Ala Val         
                485                 490                 495             

gag gtg gtg aca ttg gaa cag tga catacagcca tattatggca tcgttttcta    1659
Glu Val Val Thr Leu Glu Gln                                             
            500                                                         

gtctacttca aaatttttta cacgtttgca gaggtgcaat caaatggaat taagtctctc   1719

gactttggaa ggaaagtttt gttaaccttt ttttttttaa aaggaagaaa gcggattttg   1779

gaattgcatt ttttaaagca ccactcttga ttttctggga ttggtgaaga aactgcattg   1839

tcaatttcac tgtcccaaaa aagccaaatt gtggcaggac ttctttctgc ggaaatgtgt   1899

gtgtatactt atgtgtgtgt atgtgtgagt gtgaatatat gtatatgtgt acatatggac   1959

atacacattt acatatatat aaagtatata tatacatata tatatatata tatgtatgaa   2019

acccgcatgg aattatctgt atgaaatcaa ggtgcgctgt ggaaacaata attcacccag   2079

tttagtgggt ggtagggtac gtggccagac acagtcaccc agtttttgtt cataccaggg   2139

tcatgcgttg agctactgac aaactcaggc ggaggtgacc atgcccttca ccaaagctgc   2199

ctcccagtgg ccacacagaa ctctccctgc tggactcacc tgaggaaaga ggctccagca   2259

tggggtgggt cagagatgtg cttgcaaggt ccagggactg cgtggtctgc cagctgagat   2319

gctcctcggg ctggcccagg tgctgacctt gccacaggca gatgaatgtc ttgaaagctc   2379

ccgggcctca gcctcccatc tcctctcctt cccaggaatc cttgatctca tgactattaa   2439

aatgttgctc tggttttaag gtcagtcctg aattgctcgt atatatgaac tgaaggtaac   2499

cgaagtatta ggggtttgag gagtgcgtgc gtgtaagtgt gcttgtgtgt gtgcgtgcat   2559

ggtgggggag aggatgggaa gggggcgggg gcagtggaag ggaaaggaag gaaagaaaaa   2619

tcgtcctaga ccaggataca cccgtgggag caattttctc tactgtctgt agcttcacag   2679

aggaggcgct ggaatgaaca agaagagaca tctggtctgt ggccacagca ccctgaacgc   2739

ccctgatctt gtgtgatctt ggaagctaag cttggttggg cccggtcagt acgcggaagg   2799

gaagaaggga cacctggcca tagaaaacag ctgagggtgt ttgctgtgtt cctggatcag   2859

gccctgcttc agaagggact cctggaggcc catgttcctt gatgcaacct cgtggcccag   2919

gccgggagca gcttgcctcc tcagaggtgt tgactatctg ggtgttcttg gtaaccgtta   2979

actctgtctt tctcagctgc aagccctgag tctccagtag ctgaattcac ctgacttttc   3039

aacaggccaa atctctgaac cttgagtaca gggacagctc ctcctccctc ctcccagctc   3099

tccccatgtg tgtgatggtg tatttaatgt gtttttttaa tgcgacatta aaagattctc   3159

cacgtcttgc tcaacctttg agagaagttt cagattcttg tatttgcttg ttttatataa   3219

aactatctaa tgttctttat atgttctttt ctgtacgtaa tggggggagg ggagggaaat   3279

ttacatataa atagtcctag ttctacaatt tgttattttt ttaattatta ttttttatcg   3339

tcattgtgaa gttgtccagg gactttaaag tccatgttcc tttgtggtga aataacctcc   3399

aaatagtttg agaagttgcc aagacgaaga aaaaagcaaa accccagtag cagagcatgg   3459

attctgtgtt gtttcccatt ctgtctttga ctgcctcatt caataaatag ttaaaaatgt   3519

ggcaacagga aaaaaaaaaa a                                             3540


<210>  4
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Glu His Gly Val Thr Gln Thr Glu His Met Ala Thr Ile Glu 
1               5                   10                  15      


Ala His Ala Val Ala Gln Gln Val Gln Gln Val His Val Ala Thr Tyr 
            20                  25                  30          


Thr Glu His Ser Met Leu Ser Ala Asp Glu Asp Ser Pro Ser Ser Pro 
        35                  40                  45              


Glu Asp Thr Ser Tyr Asp Asp Ser Asp Ile Leu Asn Ser Thr Ala Ala 
    50                  55                  60                  


Asp Glu Val Thr Ala His Leu Ala Ala Ala Gly Pro Val Gly Met Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Val Ala Thr Gly Lys Lys Arg Lys Arg Pro His Val 
                85                  90                  95      


Phe Glu Ser Asn Pro Ser Ile Arg Lys Arg Gln Gln Thr Arg Leu Leu 
            100                 105                 110         


Arg Lys Leu Arg Ala Thr Leu Asp Glu Tyr Thr Thr Arg Val Gly Gln 
        115                 120                 125             


Gln Ala Ile Val Leu Cys Ile Ser Pro Ser Lys Pro Asn Pro Val Phe 
    130                 135                 140                 


Lys Val Phe Gly Ala Ala Pro Leu Glu Asn Val Val Arg Lys Tyr Lys 
145                 150                 155                 160 


Ser Met Ile Leu Glu Asp Leu Glu Ser Ala Leu Ala Glu His Ala Pro 
                165                 170                 175     


Ala Pro Gln Glu Val Asn Ser Glu Leu Pro Pro Leu Thr Ile Asp Gly 
            180                 185                 190         


Ile Pro Val Ser Val Asp Lys Met Thr Gln Ala Gln Leu Arg Ala Phe 
        195                 200                 205             


Ile Pro Glu Met Leu Lys Tyr Ser Thr Gly Arg Gly Lys Pro Gly Trp 
    210                 215                 220                 


Gly Lys Glu Ser Cys Lys Pro Ile Trp Trp Pro Glu Asp Ile Pro Trp 
225                 230                 235                 240 


Ala Asn Val Arg Ser Asp Val Arg Thr Glu Glu Gln Lys Gln Arg Val 
                245                 250                 255     


Ser Trp Thr Gln Ala Leu Arg Thr Ile Val Lys Asn Cys Tyr Lys Gln 
            260                 265                 270         


His Gly Arg Glu Asp Leu Leu Tyr Ala Phe Glu Asp Gln Gln Thr Gln 
        275                 280                 285             


Thr Gln Ala Thr Ala Thr His Ser Ile Ala His Leu Val Pro Ser Gln 
    290                 295                 300                 


Thr Val Val Gln Thr Phe Ser Asn Pro Asp Gly Thr Val Ser Leu Ile 
305                 310                 315                 320 


Gln Val Gly Thr Gly Ala Thr Val Ala Thr Leu Ala Asp Ala Ser Glu 
                325                 330                 335     


Leu Pro Thr Thr Val Thr Val Ala Gln Val Asn Tyr Ser Ala Val Ala 
            340                 345                 350         


Asp Gly Glu Val Glu Gln Asn Trp Ala Thr Leu Gln Gly Gly Glu Met 
        355                 360                 365             


Thr Ile Gln Thr Thr Gln Ala Ser Glu Ala Thr Gln Ala Val Ala Ser 
    370                 375                 380                 


Leu Ala Glu Ala Ala Val Ala Ala Ser Gln Glu Met Gln Gln Gly Ala 
385                 390                 395                 400 


Thr Val Thr Met Ala Leu Asn Ser Glu Ala Ala Ala His Ala Val Ala 
                405                 410                 415     


Thr Leu Ala Glu Ala Thr Leu Gln Gly Gly Gly Gln Ile Val Leu Ser 
            420                 425                 430         


Gly Glu Thr Ala Ala Ala Val Gly Ala Leu Thr Gly Val Gln Asp Ala 
        435                 440                 445             


Asn Gly Leu Val Gln Ile Pro Val Ser Met Tyr Gln Thr Val Val Thr 
    450                 455                 460                 


Ser Leu Ala Gln Gly Asn Gly Pro Val Gln Val Ala Met Ala Pro Val 
465                 470                 475                 480 


Thr Thr Arg Ile Ser Asp Ser Ala Val Thr Met Asp Gly Gln Ala Val 
                485                 490                 495     


Glu Val Val Thr Leu Glu Gln 
            500             


<210>  5
<211>  5412
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (200)..(3508)

<400>  5
gtacgtgcgc gtctccctgc cgccgccgcc gcccgccgcg ggccgccccg gggccgccgt     60

cgccgacgac gcgcgggagg aggaggagga ggccgccccg ccgccgccgc cgccgccgcc    120

gccccggctc gccgccgccc gcccgccggg ctcgcagccc cggcccccgg ccgcaggcga    180

ggcccaggcc gcggccgac atg aac cac cag cag cag cag cag cag cag aaa     232
                     Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys        
                     1               5                   10             

gcg ggc gag cag cag ttg agc gag ccc gag gac atg gag atg gaa gcg      280
Ala Gly Glu Gln Gln Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala         
            15                  20                  25                  

gga gat aca gat gac cca cca aga att act cag aac cct gtg atc aat      328
Gly Asp Thr Asp Asp Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn         
        30                  35                  40                      

ggg aat gtg gcc ctg agt gat gga cac aac acc gcg gag gag gac atg      376
Gly Asn Val Ala Leu Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met         
    45                  50                  55                          

gag gat gac acc agt tgg cgc tcc gag gca acc ttt cag ttc act gtg      424
Glu Asp Asp Thr Ser Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val         
60                  65                  70                  75          

gag cgc ttc agc aga ctg agt gag tcg gtc ctt agc cct ccg tgt ttt      472
Glu Arg Phe Ser Arg Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe         
                80                  85                  90              

gtg cga aat ctg cca tgg aag att atg gtg atg cca cgc ttt tat cca      520
Val Arg Asn Leu Pro Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro         
            95                  100                 105                 

gac aga cca cac caa aaa agc gta gga ttc ttt ctc cag tgc aat gct      568
Asp Arg Pro His Gln Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala         
        110                 115                 120                     

gaa tct gat tcc acg tca tgg tct tgc cat gca caa gca gtg ctg aag      616
Glu Ser Asp Ser Thr Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys         
    125                 130                 135                         

ata ata aat tac aga gat gat gaa aag tcg ttc agt cgt cgt att agt      664
Ile Ile Asn Tyr Arg Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser         
140                 145                 150                 155         

cat ttg ttc ttc cat aaa gaa aat gat tgg gga ttt tcc aat ttt atg      712
His Leu Phe Phe His Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met         
                160                 165                 170             

gcc tgg agt gaa gtg acc gat cct gag aaa gga ttt ata gat gat gac      760
Ala Trp Ser Glu Val Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp         
            175                 180                 185                 

aaa gtt acc ttt gaa gtc ttt gta cag gcg gat gct ccc cat gga gtt      808
Lys Val Thr Phe Glu Val Phe Val Gln Ala Asp Ala Pro His Gly Val         
        190                 195                 200                     

gcg tgg gat tca aag aag cac aca ggc tac gtc ggc tta aag aat cag      856
Ala Trp Asp Ser Lys Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln         
    205                 210                 215                         

gga gcg act tgt tac atg aac agc ctg cta cag acg tta ttt ttc acg      904
Gly Ala Thr Cys Tyr Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr         
220                 225                 230                 235         

aat cag cta cga aag gct gtg tac atg atg cca acc gag ggg gat gat      952
Asn Gln Leu Arg Lys Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp         
                240                 245                 250             

tcg tct aaa agc gtc cct tta gca tta caa aga gtg ttc tat gaa tta     1000
Ser Ser Lys Ser Val Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu         
            255                 260                 265                 

cag cat agt gat aaa cct gta gga aca aaa aag tta aca aag tca ttt     1048
Gln His Ser Asp Lys Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe         
        270                 275                 280                     

ggg tgg gaa act tta gat agc ttc atg caa cat gat gtt cag gag ctt     1096
Gly Trp Glu Thr Leu Asp Ser Phe Met Gln His Asp Val Gln Glu Leu         
    285                 290                 295                         

tgt cga gtg ttg ctc gat aat gtg gaa aat aag atg aaa ggc acc tgt     1144
Cys Arg Val Leu Leu Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys         
300                 305                 310                 315         

gta gag ggc acc ata ccc aaa tta ttc cgc ggc aaa atg gtg tcc tat     1192
Val Glu Gly Thr Ile Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr         
                320                 325                 330             

atc cag tgt aaa gaa gta gac tat cgg tct gat aga aga gaa gat tat     1240
Ile Gln Cys Lys Glu Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr         
            335                 340                 345                 

tat gat atc cag cta agt atc aaa gga aag aaa aat ata ttt gaa tca     1288
Tyr Asp Ile Gln Leu Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser         
        350                 355                 360                     

ttt gtg gat tat gtg gca gta gaa cag ctc gat ggg gac aat aaa tac     1336
Phe Val Asp Tyr Val Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr         
    365                 370                 375                         

gac gct ggg gaa cat ggc tta cag gaa gca gag aaa ggt gtg aaa ttc     1384
Asp Ala Gly Glu His Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe         
380                 385                 390                 395         

cta aca ttg cca cca gtg tta cat cta caa ctg atg aga ttt atg tat     1432
Leu Thr Leu Pro Pro Val Leu His Leu Gln Leu Met Arg Phe Met Tyr         
                400                 405                 410             

gac cct cag acg gac caa aat atc aag atc aat gat agg ttt gaa ttc     1480
Asp Pro Gln Thr Asp Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe         
            415                 420                 425                 

cca gag cag tta cca ctt gat gaa ttt ttg caa aaa aca gat cct aag     1528
Pro Glu Gln Leu Pro Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys         
        430                 435                 440                     

gac cct gca aat tat att ctt cat gca gtc ctg gtt cat agt gga gat     1576
Asp Pro Ala Asn Tyr Ile Leu His Ala Val Leu Val His Ser Gly Asp         
    445                 450                 455                         

aat cat ggt gga cat tat gtg gtt tat cta aac ccc aaa ggg gat ggc     1624
Asn His Gly Gly His Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly         
460                 465                 470                 475         

aaa tgg tgt aaa ttt gat gac gac gtg gtg tca agg tgt act aaa gag     1672
Lys Trp Cys Lys Phe Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu         
                480                 485                 490             

gaa gca att gag cac aat tat ggg ggt cac gat gac gac ctg tct gtt     1720
Glu Ala Ile Glu His Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val         
            495                 500                 505                 

cga cac tgc act aat gct tac atg tta gtc tac atc agg gaa tca aaa     1768
Arg His Cys Thr Asn Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys         
        510                 515                 520                     

ctg agt gaa gtt tta cag gcg gtc acc gac cat gat att cct cag cag     1816
Leu Ser Glu Val Leu Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln         
    525                 530                 535                         

ttg gtg gag cga tta caa gaa gag aaa agg atc gag gct cag aag cgg     1864
Leu Val Glu Arg Leu Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg         
540                 545                 550                 555         

aag gag cgg cag gaa gcc cat ctc tat atg caa gtg cag ata gtc gca     1912
Lys Glu Arg Gln Glu Ala His Leu Tyr Met Gln Val Gln Ile Val Ala         
                560                 565                 570             

gag gac cag ttt tgt ggc cac caa ggg aat gac atg tac gat gaa gaa     1960
Glu Asp Gln Phe Cys Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu         
            575                 580                 585                 

aaa gtg aaa tac act gtg ttc aaa gta ttg aag aac tcc tcg ctt gct     2008
Lys Val Lys Tyr Thr Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala         
        590                 595                 600                     

gag ttt gtt cag agc ctc tct cag acc atg gga ttt cca caa gat caa     2056
Glu Phe Val Gln Ser Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln         
    605                 610                 615                         

att cga ttg tgg ccc atg caa gca agg agt aat gga aca aaa cga cca     2104
Ile Arg Leu Trp Pro Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro         
620                 625                 630                 635         

gca atg tta gat aat gaa gcc gac ggc aat aaa aca atg att gag ctc     2152
Ala Met Leu Asp Asn Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu         
                640                 645                 650             

agt gat aat gaa aac cct tgg aca ata ttc ctg gaa aca gtt gat ccc     2200
Ser Asp Asn Glu Asn Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro         
            655                 660                 665                 

gag ctg gct gct agt gga gcg acc tta ccc aag ttt gat aaa gat cat     2248
Glu Leu Ala Ala Ser Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His         
        670                 675                 680                     

gat gta atg tta ttt ttg aag atg tat gat ccc aaa acg cgg agc ttg     2296
Asp Val Met Leu Phe Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu         
    685                 690                 695                         

aat tac tgt ggg cat atc tac aca cca ata tcc tgt aaa ata cgt gac     2344
Asn Tyr Cys Gly His Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp         
700                 705                 710                 715         

ttg ctc cca gtt atg tgt gac aga gca gga ttt att caa gat act agc     2392
Leu Leu Pro Val Met Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser         
                720                 725                 730             

ctt atc ctc tat gag gaa gtt aaa ccg aat tta aca gag aga att cag     2440
Leu Ile Leu Tyr Glu Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln         
            735                 740                 745                 

gac tat gac gtg tct ctt gat aaa gcc ctt gat gaa cta atg gat ggt     2488
Asp Tyr Asp Val Ser Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly         
        750                 755                 760                     

gac atc ata gta ttt cag aag gat gac cct gaa aat gat aac agt gaa     2536
Asp Ile Ile Val Phe Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu         
    765                 770                 775                         

tta ccc acc gca aag gag tat ttc cga gat ctc tac cac cgc gtt gat     2584
Leu Pro Thr Ala Lys Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp         
780                 785                 790                 795         

gtc att ttc tgt gat aaa aca atc cct aat gat cct gga ttt gtg gtt     2632
Val Ile Phe Cys Asp Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val         
                800                 805                 810             

acg tta tca aat aga atg aat tat ttt cag gtt gca aag aca gtt gca     2680
Thr Leu Ser Asn Arg Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala         
            815                 820                 825                 

cag agg ctc aac aca gat cca atg ttg ctg cag ttt ttc aag tct caa     2728
Gln Arg Leu Asn Thr Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln         
        830                 835                 840                     

ggt tat agg gat ggc cca ggt aat cct ctt aga cat aat tat gaa ggt     2776
Gly Tyr Arg Asp Gly Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly         
    845                 850                 855                         

act tta aga gat ctt cta cag ttc ttc aag cct aga caa cct aag aaa     2824
Thr Leu Arg Asp Leu Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys         
860                 865                 870                 875         

ctt tac tat cag cag ctt aag atg aaa atc aca gac ttt gag aac agg     2872
Leu Tyr Tyr Gln Gln Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg         
                880                 885                 890             

cga agt ttt aaa tgt ata tgg tta aac agc caa ttt agg gaa gag gaa     2920
Arg Ser Phe Lys Cys Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu         
            895                 900                 905                 

ata aca cta tat cca gac aag cat ggg tgt gtc cgg gac ctg tta gaa     2968
Ile Thr Leu Tyr Pro Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu         
        910                 915                 920                     

gaa tgt aaa aag gcc gtg gag ctt ggg gag aaa gca tca ggg aaa ctt     3016
Glu Cys Lys Lys Ala Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu         
    925                 930                 935                         

agg ctg cta gaa att gta agc tac aaa atc att ggt gtt cat caa gaa     3064
Arg Leu Leu Glu Ile Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu         
940                 945                 950                 955         

gat gaa cta tta gaa tgt tta tct cct gca acg agc cgg acg ttt cga     3112
Asp Glu Leu Leu Glu Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg         
                960                 965                 970             

ata gag gaa atc cct ttg gac cag gtg gac ata gac aaa gag aat gag     3160
Ile Glu Glu Ile Pro Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu         
            975                 980                 985                 

atg ctt gtc aca gtg gcg cat ttc cac aaa gag gtc ttc  gga acg ttc    3208
Met Leu Val Thr Val Ala His Phe His Lys Glu Val Phe  Gly Thr Phe        
        990                 995                 1000                    

gga atc  ccg ttt ttg ctg agg  ata cac cag ggc gag  cat ttt cga      3253
Gly Ile  Pro Phe Leu Leu Arg  Ile His Gln Gly Glu  His Phe Arg          
    1005                 1010                 1015                      

gaa gtg  atg aag cga atc cag  agc ctg ctg gac atc  cag gag aag      3298
Glu Val  Met Lys Arg Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys          
    1020                 1025                 1030                      

gag ttt  gag aag ttt aaa ttt  gca att gta atg atg  ggc cga cac      3343
Glu Phe  Glu Lys Phe Lys Phe  Ala Ile Val Met Met  Gly Arg His          
    1035                 1040                 1045                      

cag tac  ata aat gaa gac gag  tat gaa gta aat ttg  aaa gac ttt      3388
Gln Tyr  Ile Asn Glu Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe          
    1050                 1055                 1060                      

gag cca  cag ccc ggt aat atg  tct cat cct cgg cct  tgg cta ggg      3433
Glu Pro  Gln Pro Gly Asn Met  Ser His Pro Arg Pro  Trp Leu Gly          
    1065                 1070                 1075                      

ctc gac  cac ttc aac aaa gcc  cca aag agg agt cgc  tac act tac      3478
Leu Asp  His Phe Asn Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr          
    1080                 1085                 1090                      

ctt gaa  aag gcc att aaa atc  cat aac tga tttccaagct ggtgtgttca     3528
Leu Glu  Lys Ala Ile Lys Ile  His Asn                                   
    1095                 1100                                           

aggcgaggac ggtgtgtggg tggcccctta acagcctaga actttggtgc acgtgccctc   3588

tagccgaagt cttcagcaag aggattcgct gctggtgtta attttatttt attgaggctg   3648

ttcagtttgg cttctctgta tctattgact gccctttttg agcaaaatga agatgttttt   3708

ataaagcttg gatgccaatg agagttattt tatggtaacc acagtgcaag gcaactgtca   3768

gcgcaatggg ggagaagagg ttagtggatc gggggtccct ggctcaaggt ctctgggctg   3828

tccctagtgg gcacgagtgg ctcggctgcc ttcctggggt cccgtgcacc agccctgcag   3888

ctagcaagtc ttgtgtttag gctcgtctga cctatttcct tcagttatac tttcaatgac   3948

cttttgtgca tctgttaagg caaaacagag aaactcacaa cctaataaat agcgctcttc   4008

ccttcattgt gtgcattgtc ggcccttcct cgggttctcc tcctccagct gcctgggggc   4068

tttttaataa acttgtctca cctcgtcagc cactactgtc tgcagcccct ttgcaaagtg   4128

gatgcactga atacagtccg gacagacatt gtgggggtct ttttattaaa tcaagaacat   4188

tgttaaattc aattaaggtt tactctgctg ccttggcaga cttacgatct caacagttca   4248

tacgagcagg tgaaaggatt ataaatagaa tttcgttaaa gtggaacaga cgacaagaaa   4308

gccttttagc aagagggcat gctcactagt ggttagtaag ctgtcgactt tgtaaaaaag   4368

ttaaaaatga aaaaaaaagg aaaaatgaat tgtatattta atgaatgaac atgtacaatt   4428

tgccactggg aggaggttcc tttttgttgg gtgagtctgc aagtgaattt cactgatgtt   4488

gatattcatt gtgtgtagtt ttatttcggt cccagccccg tttcctttta ttttggagct   4548

aatgccagct gcgtgtctag ttttgagtgc agtaaaatag aatcagcaaa tcactcttat   4608

ttttcatcct tttccggtat tttttgggtt gtttctgtgg gagcagtgta caccaactct   4668

tcctgtatat tgcctttttg ctggaaaatg ttgtatgttg aataaaattt tctataaaaa   4728

ttataattca gtgagttacg tggaagtgga ggaagatttc tactctccct ggaaacaggc   4788

ctgggaaacc ttggcatttg taacaaggtt tcactgagat gtacttttcc ttctaattcc   4848

gttttgcggg ggcagggtct cttgtttctt tttttttttt tttttttttt tagcctctaa   4908

ctagtcacat ttactcttaa gaaatgaaag gttttccagg agagaactgt gtacaaataa   4968

ggtgactgga gatgtgacct gatgtgtcac gaggcccttc ggggcggcag gcgctatcgt   5028

gggcgtggtc cttgcaccgt cccatcggcc ttgccttcca gctccgtggc acggtttcct   5088

ggtctttggg ccagtgtgta ccttggagtg acttcctttc tcaacttcca ctgcagtgtg   5148

tgtgccttct gctctgagag ctgccttgtg acccgtgtga tagaaagcag ggagtgaggg   5208

tccccgcgga cctggccctt ccctccttcc tcccccagaa agaggagtta gagcaggggt   5268

gcgagagccg ttcgctgtgg gtttgtcttt gaacaaacat taaggtgtct tgtttttgtt   5328

ctgggctggg ggttggctgt agtcttaggt aactgaaagt tcctactctc ccttaaggta   5388

ttaaatgact ctttttccaa agaa                                          5412


<210>  6
<211>  1102
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln 
1               5                   10                  15      


Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp 
            20                  25                  30          


Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu 
        35                  40                  45              


Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser 
    50                  55                  60                  


Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg 
65                  70                  75                  80  


Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro 
                85                  90                  95      


Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln 
            100                 105                 110         


Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr 
        115                 120                 125             


Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg 
    130                 135                 140                 


Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His 
145                 150                 155                 160 


Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val 
                165                 170                 175     


Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu 
            180                 185                 190         


Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys 
        195                 200                 205             


Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr 
    210                 215                 220                 


Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys 
225                 230                 235                 240 


Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val 
                245                 250                 255     


Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys 
            260                 265                 270         


Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu 
        275                 280                 285             


Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu 
    290                 295                 300                 


Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu 
                325                 330                 335     


Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu 
            340                 345                 350         


Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val 
        355                 360                 365             


Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His 
    370                 375                 380                 


Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro 
385                 390                 395                 400 


Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp 
                405                 410                 415     


Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro 
            420                 425                 430         


Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr 
        435                 440                 445             


Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His 
    450                 455                 460                 


Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe 
465                 470                 475                 480 


Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His 
                485                 490                 495     


Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn 
            500                 505                 510         


Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu 
        515                 520                 525             


Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu 
    530                 535                 540                 


Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu 
545                 550                 555                 560 


Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys 
                565                 570                 575     


Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr 
            580                 585                 590         


Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser 
        595                 600                 605             


Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro 
    610                 615                 620                 


Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn 
625                 630                 635                 640 


Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn 
                645                 650                 655     


Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser 
            660                 665                 670         


Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe 
        675                 680                 685             


Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His 
    690                 695                 700                 


Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met 
705                 710                 715                 720 


Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu 
                725                 730                 735     


Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser 
            740                 745                 750         


Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe 
        755                 760                 765             


Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys 
    770                 775                 780                 


Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp 
785                 790                 795                 800 


Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg 
                805                 810                 815     


Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr 
            820                 825                 830         


Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly 
        835                 840                 845             


Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu 
    850                 855                 860                 


Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln 
865                 870                 875                 880 


Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys 
                885                 890                 895     


Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro 
            900                 905                 910         


Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala 
        915                 920                 925             


Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile 
    930                 935                 940                 


Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu 
945                 950                 955                 960 


Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro 
                965                 970                 975     


Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val 
            980                 985                 990         


Ala His Phe His Lys Glu Val Phe  Gly Thr Phe Gly Ile  Pro Phe Leu 
        995                 1000                 1005             


Leu Arg  Ile His Gln Gly Glu  His Phe Arg Glu Val  Met Lys Arg 
    1010                 1015                 1020             


Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys Glu Phe  Glu Lys Phe 
    1025                 1030                 1035             


Lys Phe  Ala Ile Val Met Met  Gly Arg His Gln Tyr  Ile Asn Glu 
    1040                 1045                 1050             


Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe Glu Pro  Gln Pro Gly 
    1055                 1060                 1065             


Asn Met  Ser His Pro Arg Pro  Trp Leu Gly Leu Asp  His Phe Asn 
    1070                 1075                 1080             


Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr Leu Glu  Lys Ala Ile 
    1085                 1090                 1095             


Lys Ile  His Asn 
    1100         


<210>  7
<211>  1675
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1005)..(1208)

<400>  7
acagcaatca aatcagtgac tgccagggac tgggaggtgg gggtgataga tatattctac     60

ttcttaaaaa aaaaaaatca aagtatatat cctaaaacag tgattttact gtatgtaaat    120

tacactccca gaaacctttt ttttaattaa gtattatttc aaaattctgt ttttggacaa    180

aaccaagagc cattccaaaa cgttcaagac cgtcagcact gatagatgtt gaagcaattt    240

actcagtcac aatttaacaa acagctatat aaaatcaaag ctaaccactg aggcactatt    300

taaccatgtt tccctttttt cagtaagact ggactattat tattacagtt cctcattccc    360

taaagttagc gtttcttttc accactttgt taccagttct caaattactg tcccaaaaaa    420

ctgtagtcta ctcaagaaat ctcacaagga gatatttttt cctacaagat gctgcggcca    480

tttgcacatt cttatgcaaa aattaacaac ttgacagtca agcagcacct tcatagcccg    540

tttcaaccta tatatggcct aaatatatat ggcaaaaata ccaatattgg tatttttgaa    600

atgcacaaag ttccattact gttctgagca acttttaaaa gtctgaaaac atttaattac    660

atatttctta agattaacaa agtcaaatcc tttttccata aaaatcttgc caaaaaaaaa    720

aatcaacccc aaatttctca atcttcaaaa ccagtaaggc acaaaatcta aacccaccgt    780

taccaagaat gcacaaatgg gcaagaacgt ttacttacac atcttcatgt catcacaaag    840

ggagggggat taactccaga aaggaaccac cataaaacaa acctatggac tcaaaactct    900

caacagaatt cctgccagca acctataatc aaatatagga tccttttaac agaaaacact    960

tgatcaaatt gctagagaag agcagcacgt taacatgcgc gcag atg act ccg att    1016
                                                 Met Thr Pro Ile        
                                                 1                      

agc aag ctt tca agc act tca aaa cta tat aga ctg cca cgc ttt caa     1064
Ser Lys Leu Ser Ser Thr Ser Lys Leu Tyr Arg Leu Pro Arg Phe Gln         
5                   10                  15                  20          

atg cct aac tca aga atc ttt tcc ata aag ttc gtc cca ctt ccg act     1112
Met Pro Asn Ser Arg Ile Phe Ser Ile Lys Phe Val Pro Leu Pro Thr         
                25                  30                  35              

gta gta caa aaa aca tca act ctt atc ttc cct caa tgt ctt ttc cag     1160
Val Val Gln Lys Thr Ser Thr Leu Ile Phe Pro Gln Cys Leu Phe Gln         
            40                  45                  50                  

agg gag gca agg ctc agc cgt ctt cca gct caa cgc ttc tca acc tga     1208
Arg Glu Ala Arg Leu Ser Arg Leu Pro Ala Gln Arg Phe Ser Thr             
        55                  60                  65                      

gcactactga ctttaggggc aggataattc ttcgctgaga gggggccggg gcggttatct   1268

tgggcactgc aggaccttca gcagcctcta tacactgggt gcccaacaac agccccttct   1328

aggagaagcc aaccaaaaac gtccccaggc gttgccatct gtcccggggg gcggagggag   1388

gtgtcaaaat cgcctccggt ggatctagct agagcaccgc cgcgattctc aagttgcaag   1448

gtattcaagg ttagcagctg ggctggggag cagaaaacac acttggaacg cagggcagac   1508

accctgacgc aggcggccct tccctgaatc ggcaatgcag caaggttatc tttacctttg   1568

tagagattgg tgacggcggt ggctgcgttt tggaagggga cccagagaga aagtcctggc   1628

tgctgacaca ctcggtctga aaagcaagcc aaaaaaaaaa aaaaaaa                 1675


<210>  8
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Pro Ile Ser Lys Leu Ser Ser Thr Ser Lys Leu Tyr Arg Leu 
1               5                   10                  15      


Pro Arg Phe Gln Met Pro Asn Ser Arg Ile Phe Ser Ile Lys Phe Val 
            20                  25                  30          


Pro Leu Pro Thr Val Val Gln Lys Thr Ser Thr Leu Ile Phe Pro Gln 
        35                  40                  45              


Cys Leu Phe Gln Arg Glu Ala Arg Leu Ser Arg Leu Pro Ala Gln Arg 
    50                  55                  60                  


Phe Ser Thr 
65          


<210>  9
<211>  2540
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (287)..(736)

<400>  9
attgggctgt tgagcggggg ccgaccgacg gccaggagtt tcttttctgc gcttgtgcgt     60

tttctgttcg gtttccttcc cgctagcggg gccacgaggg ttgctaggca acagcccctg    120

ggtgacttgg tcttagggtc ctgtccggct tggggctgat gaaaggagct gtccgcgccc    180

gggctcttcc gagaagtggt tgctgacagc cacaaagtga aagggagtga ggcggcgtgg    240

acgagtaagg agtgacagtg aggattcaca tttgggttat ttcaag atg agc ttc       295
                                                   Met Ser Phe          
                                                   1                    

cta ctg ccc aag ctg act agc aaa aag gaa gta gac cag gcg ata aaa      343
Leu Leu Pro Lys Leu Thr Ser Lys Lys Glu Val Asp Gln Ala Ile Lys         
    5                   10                  15                          

agt act gct gag aag gtg ttg gtt ctc agg ttt ggg aga gat gaa gat      391
Ser Thr Ala Glu Lys Val Leu Val Leu Arg Phe Gly Arg Asp Glu Asp         
20                  25                  30                  35          

cct gtc tgt ctg cag cta gat gat att ctt tct aag acc tct tct gac      439
Pro Val Cys Leu Gln Leu Asp Asp Ile Leu Ser Lys Thr Ser Ser Asp         
                40                  45                  50              

tta agt aaa atg gct gct ata tac ctg gtg gat gtg gac caa act gca      487
Leu Ser Lys Met Ala Ala Ile Tyr Leu Val Asp Val Asp Gln Thr Ala         
            55                  60                  65                  

gtt tat aca cag tat ttt gac atc agt tat att cca tct act gtc ttt      535
Val Tyr Thr Gln Tyr Phe Asp Ile Ser Tyr Ile Pro Ser Thr Val Phe         
        70                  75                  80                      

ttc ttc aat ggg cag cat atg aaa gtg gat tat gga tct cca gat cac      583
Phe Phe Asn Gly Gln His Met Lys Val Asp Tyr Gly Ser Pro Asp His         
    85                  90                  95                          

act aag ttt gtg gga agc ttc aaa acc aaa caa gac ttc ata gat ttg      631
Thr Lys Phe Val Gly Ser Phe Lys Thr Lys Gln Asp Phe Ile Asp Leu         
100                 105                 110                 115         

att gaa gta atc tat cga gga gca atg agg ggg aag ctt att gtc caa      679
Ile Glu Val Ile Tyr Arg Gly Ala Met Arg Gly Lys Leu Ile Val Gln         
                120                 125                 130             

agt cct att gat ccc aag aat att ccc aaa tat gac ctt ctc tat caa      727
Ser Pro Ile Asp Pro Lys Asn Ile Pro Lys Tyr Asp Leu Leu Tyr Gln         
            135                 140                 145                 

gac att tag tacattaatt gctgtcaaag atgaagaaga aggcacatct              776
Asp Ile                                                                 
                                                                        

tgacacagta cctgaatcca gctgtgctgt gtttctggag tcctttggaa acatgtgtcc    836

cagaggagaa gaggtttgac ttgcgtgtag aaaacccggc ccctgaggaa aagaccccac    896

tggttctctg atgacctggg atgcctaact gtctactccc tgcaagcctc agagcagcca    956

agtcattggt gttcattttc cccacagtga tttttgtaac ttctctttct aatgtttttc   1016

tttatccctt taatacagaa ccctcccaaa cattggctag tacaacttga tttcatcatg   1076

ttcatttgat acacaagtga actggaaagt cacttcccat agaagcaaaa gtacttattt   1136

tctaccctag ctgggtgcat gtgtgtgcac acacacacac acacacaccc ccacacccct   1196

ttgccggttc ctcgactcat acatccctcg tgctttccca tctccagtct gtattactgt   1256

aggttctctt caaataatta attgagcaga caagtttgtt ttattttgga gcctttttgg   1316

ctctggcttt taaacattgt cctggttggc tcatttaatt tttttttttt ttttgagacc   1376

gagtcactct tgtcacccag gctggagtgc agtggcgcga tctcggctca ctgcaagctc   1436

cacctcctgg gttcatgcca ttctcctgct tcagcctcct gagtagctgg gactacaggc   1496

gcccgccacc atgcccagct aattttttgt atttttatag aggcgcagtt tcaccgtgtt   1556

agccaagatg gtctcgatct cctgacctcg tgatctgccc tcctcagcct cccaggtgct   1616

gggattatag gcgtgagcca ccgcgcgcac cccatttaat tattttttat gttataaaat   1676

ttaatatgga aagtgagaat ttgaaccttc accatccacc actctattca ggtaaaacaa   1736

tgaatgagcc accttagcag gagcagattt ttcccagaag ctgctgcctc ttcctgaggc   1796

agaaaattgg attactaagg ctcaaaacta aaagagatgt cagcattgtt ggatagaaat   1856

gtcacctata tgggatttgc ctgttttaat aactttgtaa ggaattcttg ctcttctagg   1916

ggtgcctggc gcaaccgtgg gcaagttact gctcctcttt aaacctcgtg gtggttattg   1976

aaacagattt attagaagga gagggtaggt gcagagctgg agagccatgg gtgaggcagc   2036

ttgtgacctg cctagcagcc gctgaccacc tctccaacag aagcctagtc ctgttcagag   2096

cagcactgtc actgcaagtc cagccccctt tgccaggggc tccattccac ccctttcctg   2156

cagggagggg tgccatgagt cttgcttttg gctcatacag gagagaggga aggctgccag   2216

gcactgcttg tatccctgct gataagagga gggagtcact ccaggaataa gacaaaagga   2276

gaggaggagg ccatcacctc tggcctcttc catcgtacac ttcctgtctc tggtttaatc   2336

atgatgcatg gagctacaac agccatctta ggtccccgag gtgcccagca tcacgtaaaa   2396

catcgatatg ctaagaagaa caaaaagagc ccaatctctg atgttattga gctcctgcat   2456

gaactctgga cctgcctgcc tcagacttct gtgaaagaat aaaatttctt tttgcctaaa   2516

aaaaaaaaaa aaaaaaaaaa aaaa                                          2540


<210>  10
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Phe Leu Leu Pro Lys Leu Thr Ser Lys Lys Glu Val Asp Gln 
1               5                   10                  15      


Ala Ile Lys Ser Thr Ala Glu Lys Val Leu Val Leu Arg Phe Gly Arg 
            20                  25                  30          


Asp Glu Asp Pro Val Cys Leu Gln Leu Asp Asp Ile Leu Ser Lys Thr 
        35                  40                  45              


Ser Ser Asp Leu Ser Lys Met Ala Ala Ile Tyr Leu Val Asp Val Asp 
    50                  55                  60                  


Gln Thr Ala Val Tyr Thr Gln Tyr Phe Asp Ile Ser Tyr Ile Pro Ser 
65                  70                  75                  80  


Thr Val Phe Phe Phe Asn Gly Gln His Met Lys Val Asp Tyr Gly Ser 
                85                  90                  95      


Pro Asp His Thr Lys Phe Val Gly Ser Phe Lys Thr Lys Gln Asp Phe 
            100                 105                 110         


Ile Asp Leu Ile Glu Val Ile Tyr Arg Gly Ala Met Arg Gly Lys Leu 
        115                 120                 125             


Ile Val Gln Ser Pro Ile Asp Pro Lys Asn Ile Pro Lys Tyr Asp Leu 
    130                 135                 140                 


Leu Tyr Gln Asp Ile 
145                 


<210>  11
<211>  3779
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (26)..(3637)

<400>  11
gcgtcgagct cgccgcggac tcaag atg gcg gcg tgt gga cgt gta cgg agg       52
                            Met Ala Ala Cys Gly Arg Val Arg Arg         
                            1               5                           

atg ttc cgc ttg tcg gcg gcg ctg cat ctg ctg ctg cta ttc gcg gcc      100
Met Phe Arg Leu Ser Ala Ala Leu His Leu Leu Leu Leu Phe Ala Ala         
10                  15                  20                  25          

ggg gcc gag aaa ctc ccc ggc cag ggc gtc cac agc cag ggc cag ggt      148
Gly Ala Glu Lys Leu Pro Gly Gln Gly Val His Ser Gln Gly Gln Gly         
                30                  35                  40              

ccc ggg gcc aac ttt gtg tcc ttc gta ggg cag gcc gga ggc ggc ggc      196
Pro Gly Ala Asn Phe Val Ser Phe Val Gly Gln Ala Gly Gly Gly Gly         
            45                  50                  55                  

ccg gcg ggt cag cag ctg ccc cag ctg cct cag tca tcg cag ctt cag      244
Pro Ala Gly Gln Gln Leu Pro Gln Leu Pro Gln Ser Ser Gln Leu Gln         
        60                  65                  70                      

cag caa cag cag cag cag caa cag caa cag cag cct cag ccg ccg cag      292
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln Pro Pro Gln         
    75                  80                  85                          

ccg cct ttc ccg gcg ggt ggg cct ccg gcc cgg cgg gga gga gcg ggg      340
Pro Pro Phe Pro Ala Gly Gly Pro Pro Ala Arg Arg Gly Gly Ala Gly         
90                  95                  100                 105         

gct ggt ggg ggc tgg aag ctg gcg gag gaa gag tcc tgc agg gag gac      388
Ala Gly Gly Gly Trp Lys Leu Ala Glu Glu Glu Ser Cys Arg Glu Asp         
                110                 115                 120             

gtg acc cgc gtg tgc cct aag cac acc tgg agc aac aac ctg gcg gtg      436
Val Thr Arg Val Cys Pro Lys His Thr Trp Ser Asn Asn Leu Ala Val         
            125                 130                 135                 

ctc gag tgc ctg cag gat gtg agg gag cct gaa aat gaa att tct tca      484
Leu Glu Cys Leu Gln Asp Val Arg Glu Pro Glu Asn Glu Ile Ser Ser         
        140                 145                 150                     

gac tgc aat cat ttg ttg tgg aat tat aag ctg aac cta act aca gat      532
Asp Cys Asn His Leu Leu Trp Asn Tyr Lys Leu Asn Leu Thr Thr Asp         
    155                 160                 165                         

ccc aaa ttt gaa tct gtg gcc aga gag gtt tgc aaa tct act ata aca      580
Pro Lys Phe Glu Ser Val Ala Arg Glu Val Cys Lys Ser Thr Ile Thr         
170                 175                 180                 185         

gag att aaa gaa tgt gct gat gaa ccg gtt gga aaa ggt tac atg gtt      628
Glu Ile Lys Glu Cys Ala Asp Glu Pro Val Gly Lys Gly Tyr Met Val         
                190                 195                 200             

tcc tgc ttg gtg gat cac cga ggc aac atc act gag tat cag tgt cac      676
Ser Cys Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln Cys His         
            205                 210                 215                 

cag tac att acc aag atg acg gcc atc att ttt agt gat tac cgt tta      724
Gln Tyr Ile Thr Lys Met Thr Ala Ile Ile Phe Ser Asp Tyr Arg Leu         
        220                 225                 230                     

atc tgt ggc ttc atg gat gac tgc aaa aat gac atc aac att ctg aaa      772
Ile Cys Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Ile Leu Lys         
    235                 240                 245                         

tgt ggc agt att cgg ctt gga gaa aag gat gca cat tca caa ggt gag      820
Cys Gly Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln Gly Glu         
250                 255                 260                 265         

gtg gta tca tgc ttg gag aaa ggc ctg gtg aaa gaa gca gaa gaa aga      868
Val Val Ser Cys Leu Glu Lys Gly Leu Val Lys Glu Ala Glu Glu Arg         
                270                 275                 280             

gaa ccc aag att caa gtt tct gaa ctc tgc aag aaa gcc att ctc cgg      916
Glu Pro Lys Ile Gln Val Ser Glu Leu Cys Lys Lys Ala Ile Leu Arg         
            285                 290                 295                 

gtg gct gag ctg tca tcg gat gac ttt cac tta gac cgg cat tta tat      964
Val Ala Glu Leu Ser Ser Asp Asp Phe His Leu Asp Arg His Leu Tyr         
        300                 305                 310                     

ttt gct tgc cga gat gat cgg gag cgt ttt tgt gaa aat aca caa gct     1012
Phe Ala Cys Arg Asp Asp Arg Glu Arg Phe Cys Glu Asn Thr Gln Ala         
    315                 320                 325                         

ggt gag ggc aga gtg tat aag tgc ctc ttt aac cat aaa ttt gaa gaa     1060
Gly Glu Gly Arg Val Tyr Lys Cys Leu Phe Asn His Lys Phe Glu Glu         
330                 335                 340                 345         

tcc atg agt gaa aag tgt cga gaa gca ctt aca acc cgc caa aag ctg     1108
Ser Met Ser Glu Lys Cys Arg Glu Ala Leu Thr Thr Arg Gln Lys Leu         
                350                 355                 360             

att gcc cag gat tat aaa gtc agt tat tca ttg gcc aaa tcc tgt aaa     1156
Ile Ala Gln Asp Tyr Lys Val Ser Tyr Ser Leu Ala Lys Ser Cys Lys         
            365                 370                 375                 

agt gac ttg aag aaa tac cgg tgc aat gtg gaa aac ctt ccg cga tcg     1204
Ser Asp Leu Lys Lys Tyr Arg Cys Asn Val Glu Asn Leu Pro Arg Ser         
        380                 385                 390                     

cgt gaa gcc agg ctc tcc tac ttg tta atg tgc ctg gag tca gct gta     1252
Arg Glu Ala Arg Leu Ser Tyr Leu Leu Met Cys Leu Glu Ser Ala Val         
    395                 400                 405                         

cac aga ggg cga caa gtc agc agt gag tgc cag ggg gag atg ctg gat     1300
His Arg Gly Arg Gln Val Ser Ser Glu Cys Gln Gly Glu Met Leu Asp         
410                 415                 420                 425         

tac cga cgc atg ttg atg gaa gac ttt tct ctg agc cct gag atc atc     1348
Tyr Arg Arg Met Leu Met Glu Asp Phe Ser Leu Ser Pro Glu Ile Ile         
                430                 435                 440             

cta agc tgt cgg ggg gag att gaa cac cat tgt tcc gga tta cat cga     1396
Leu Ser Cys Arg Gly Glu Ile Glu His His Cys Ser Gly Leu His Arg         
            445                 450                 455                 

aaa ggg cgg acc cta cac tgt ctg atg aaa gta gtt cga ggg gag aag     1444
Lys Gly Arg Thr Leu His Cys Leu Met Lys Val Val Arg Gly Glu Lys         
        460                 465                 470                     

ggg aac ctt gga atg aac tgc cag cag gcg ctt caa aca ctg att cag     1492
Gly Asn Leu Gly Met Asn Cys Gln Gln Ala Leu Gln Thr Leu Ile Gln         
    475                 480                 485                         

gag act gac cct ggt gca gat tac cgc att gat cga gct ttg aat gaa     1540
Glu Thr Asp Pro Gly Ala Asp Tyr Arg Ile Asp Arg Ala Leu Asn Glu         
490                 495                 500                 505         

gct tgt gaa tct gta atc cag aca gcc tgc aaa cat ata aga tct gga     1588
Ala Cys Glu Ser Val Ile Gln Thr Ala Cys Lys His Ile Arg Ser Gly         
                510                 515                 520             

gac cca atg atc ttg tcg tgc ctg atg gaa cat tta tac aca gag aag     1636
Asp Pro Met Ile Leu Ser Cys Leu Met Glu His Leu Tyr Thr Glu Lys         
            525                 530                 535                 

atg gta gaa gac tgt gaa cac cgt ctc tta gag ctg cag tat ttc atc     1684
Met Val Glu Asp Cys Glu His Arg Leu Leu Glu Leu Gln Tyr Phe Ile         
        540                 545                 550                     

tcc cgg gat tgg aag ctg gac cct gtc ctg tac cgc aag tgc cag gga     1732
Ser Arg Asp Trp Lys Leu Asp Pro Val Leu Tyr Arg Lys Cys Gln Gly         
    555                 560                 565                         

gac gct tct cgt ctt tgc cac acc cac ggt tgg aat gag acc agt gaa     1780
Asp Ala Ser Arg Leu Cys His Thr His Gly Trp Asn Glu Thr Ser Glu         
570                 575                 580                 585         

ttt atg cct cag gga gct gtg ttc tct tgt tta tac aga cac gcc tac     1828
Phe Met Pro Gln Gly Ala Val Phe Ser Cys Leu Tyr Arg His Ala Tyr         
                590                 595                 600             

cgc act gag gaa cag gga agg agg ctc tca cgg gag tgc cga gct gaa     1876
Arg Thr Glu Glu Gln Gly Arg Arg Leu Ser Arg Glu Cys Arg Ala Glu         
            605                 610                 615                 

gtc caa agg atc cta cac cag cgt gcc atg gat gtc aag ctg gat cct     1924
Val Gln Arg Ile Leu His Gln Arg Ala Met Asp Val Lys Leu Asp Pro         
        620                 625                 630                     

gcc ctc cag gat aag tgc ctg att gat ctg gga aaa tgg tgc agt gag     1972
Ala Leu Gln Asp Lys Cys Leu Ile Asp Leu Gly Lys Trp Cys Ser Glu         
    635                 640                 645                         

aaa aca gag act gga cag gag ctg gag tgc ctt cag gac cat ctg gat     2020
Lys Thr Glu Thr Gly Gln Glu Leu Glu Cys Leu Gln Asp His Leu Asp         
650                 655                 660                 665         

gac ttg gtg gtg gag tgt aga gat ata gtt ggc aac ctc act gag tta     2068
Asp Leu Val Val Glu Cys Arg Asp Ile Val Gly Asn Leu Thr Glu Leu         
                670                 675                 680             

gaa tca gag gat att caa ata gaa gcc ttg ctg atg aga gcc tgt gag     2116
Glu Ser Glu Asp Ile Gln Ile Glu Ala Leu Leu Met Arg Ala Cys Glu         
            685                 690                 695                 

ccc ata att cag aac ttc tgc cac gat gtg gca gat aac cag ata gac     2164
Pro Ile Ile Gln Asn Phe Cys His Asp Val Ala Asp Asn Gln Ile Asp         
        700                 705                 710                     

tct ggg gac ctg atg gag tgt ctg ata cag aac aaa cac cag aag gac     2212
Ser Gly Asp Leu Met Glu Cys Leu Ile Gln Asn Lys His Gln Lys Asp         
    715                 720                 725                         

atg aac gag aag tgt gcc atc gga gtt acc cac ttc cag ctg gtg cag     2260
Met Asn Glu Lys Cys Ala Ile Gly Val Thr His Phe Gln Leu Val Gln         
730                 735                 740                 745         

atg aag gat ttt cgg ttt tct tac aag ttt aaa atg gcc tgc aag gag     2308
Met Lys Asp Phe Arg Phe Ser Tyr Lys Phe Lys Met Ala Cys Lys Glu         
                750                 755                 760             

gac gtg ttg aag ctt tgc cca aac ata aaa aag aag gtg gac gtg gtg     2356
Asp Val Leu Lys Leu Cys Pro Asn Ile Lys Lys Lys Val Asp Val Val         
            765                 770                 775                 

atc tgc ctg agc acg acc gtg cgc aat gac act ctg cag gaa gcc aag     2404
Ile Cys Leu Ser Thr Thr Val Arg Asn Asp Thr Leu Gln Glu Ala Lys         
        780                 785                 790                     

gag cac agg gtg tcc ctg aag tgc cgc agg cag ctc cgt gtg gag gag     2452
Glu His Arg Val Ser Leu Lys Cys Arg Arg Gln Leu Arg Val Glu Glu         
    795                 800                 805                         

ctg gag atg acg gag gac atc cgc ttg gag cca gat cta tac gaa gcc     2500
Leu Glu Met Thr Glu Asp Ile Arg Leu Glu Pro Asp Leu Tyr Glu Ala         
810                 815                 820                 825         

tgc aag agt gac atc aaa aac ttc tgt tcc gct gtg caa tat ggc aac     2548
Cys Lys Ser Asp Ile Lys Asn Phe Cys Ser Ala Val Gln Tyr Gly Asn         
                830                 835                 840             

gct cag att atc gaa tgt ctg aaa gaa aac aag aag cag cta agc acc     2596
Ala Gln Ile Ile Glu Cys Leu Lys Glu Asn Lys Lys Gln Leu Ser Thr         
            845                 850                 855                 

cgc tgc cac caa aaa gta ttt aag ctg cag gag aca gag atg atg gac     2644
Arg Cys His Gln Lys Val Phe Lys Leu Gln Glu Thr Glu Met Met Asp         
        860                 865                 870                     

cca gag cta gac tac acc ctc atg agg gtc tgc aag cag atg ata aag     2692
Pro Glu Leu Asp Tyr Thr Leu Met Arg Val Cys Lys Gln Met Ile Lys         
    875                 880                 885                         

agg ttc tgt ccg gaa gca gat tct aaa acc atg ttg cag tgc ttg aag     2740
Arg Phe Cys Pro Glu Ala Asp Ser Lys Thr Met Leu Gln Cys Leu Lys         
890                 895                 900                 905         

caa aat aaa aac agt gaa ttg atg gat ccc aaa tgc aaa cag atg ata     2788
Gln Asn Lys Asn Ser Glu Leu Met Asp Pro Lys Cys Lys Gln Met Ile         
                910                 915                 920             

acc aag cgc cag atc acc cag aac aca gat tac cgc tta aac ccc atg     2836
Thr Lys Arg Gln Ile Thr Gln Asn Thr Asp Tyr Arg Leu Asn Pro Met         
            925                 930                 935                 

tta aga aaa gcc tgt aaa gct gac att cct aaa ttc tgt cac ggt atc     2884
Leu Arg Lys Ala Cys Lys Ala Asp Ile Pro Lys Phe Cys His Gly Ile         
        940                 945                 950                     

ctg act aag gcc aag gat gat tca gaa tta gaa gga caa gtc atc tct     2932
Leu Thr Lys Ala Lys Asp Asp Ser Glu Leu Glu Gly Gln Val Ile Ser         
    955                 960                 965                         

tgc ctg aag ctg aga tat gct gac cag cgc ctg tct tca gac tgt gaa     2980
Cys Leu Lys Leu Arg Tyr Ala Asp Gln Arg Leu Ser Ser Asp Cys Glu         
970                 975                 980                 985         

gac cag atc cga atc att atc cag gag tcc gcc ctg gac tac cgc  ctg    3028
Asp Gln Ile Arg Ile Ile Ile Gln Glu Ser Ala Leu Asp Tyr Arg  Leu        
                990                 995                 1000            

gat cct cag ctc  cag ctg cac tgc tca  gac gag atc tcc agt  cta      3073
Asp Pro Gln Leu  Gln Leu His Cys Ser  Asp Glu Ile Ser Ser  Leu          
            1005                 1010                 1015              

tgt gct gaa gaa  gca gca gcc caa gag  cag aca ggt cag gtg  gag      3118
Cys Ala Glu Glu  Ala Ala Ala Gln Glu  Gln Thr Gly Gln Val  Glu          
            1020                 1025                 1030              

gag tgc ctc aag  gtc aac ctg ctc aag  atc aaa aca gaa ttg  tgt      3163
Glu Cys Leu Lys  Val Asn Leu Leu Lys  Ile Lys Thr Glu Leu  Cys          
            1035                 1040                 1045              

aaa aag gaa gtg  cta aac atg ctg aag  gaa agc aaa gca gac  atc      3208
Lys Lys Glu Val  Leu Asn Met Leu Lys  Glu Ser Lys Ala Asp  Ile          
            1050                 1055                 1060              

ttt gtt gac ccg  gta ctt cat act gct  tgt gcc ctg gac att  aaa      3253
Phe Val Asp Pro  Val Leu His Thr Ala  Cys Ala Leu Asp Ile  Lys          
            1065                 1070                 1075              

cac cac tgc gca  gcc atc acc cct ggc  cgc ggg cgt caa atg  tcc      3298
His His Cys Ala  Ala Ile Thr Pro Gly  Arg Gly Arg Gln Met  Ser          
            1080                 1085                 1090              

tgt ctc atg gaa  gca ctg gag gat aag  cgg gtg agg tta cag  ccc      3343
Cys Leu Met Glu  Ala Leu Glu Asp Lys  Arg Val Arg Leu Gln  Pro          
            1095                 1100                 1105              

gag tgc aaa aag  cgc ctc aat gac cgg  att gag atg tgg agt  tac      3388
Glu Cys Lys Lys  Arg Leu Asn Asp Arg  Ile Glu Met Trp Ser  Tyr          
            1110                 1115                 1120              

gca gca aag gtg  gcc cca gca gat ggc  ttc tct gat ctt gcc  atg      3433
Ala Ala Lys Val  Ala Pro Ala Asp Gly  Phe Ser Asp Leu Ala  Met          
            1125                 1130                 1135              

caa gta atg acg  tct cca tct aag aac  tac att ctc tct gtg  atc      3478
Gln Val Met Thr  Ser Pro Ser Lys Asn  Tyr Ile Leu Ser Val  Ile          
            1140                 1145                 1150              

agt ggg agc atc  tgt ata ttg ttc ctg  att ggc ctg atg tgt  gga      3523
Ser Gly Ser Ile  Cys Ile Leu Phe Leu  Ile Gly Leu Met Cys  Gly          
            1155                 1160                 1165              

cgg atc acc aag  cga gtg aca cga gag  ctc aag gac agg cta  caa      3568
Arg Ile Thr Lys  Arg Val Thr Arg Glu  Leu Lys Asp Arg Leu  Gln          
            1170                 1175                 1180              

tac agg tca gag  aca atg gct tat aaa  ggt tta gtg tgg tct  cag      3613
Tyr Arg Ser Glu  Thr Met Ala Tyr Lys  Gly Leu Val Trp Ser  Gln          
            1185                 1190                 1195              

gat gtg aca ggc  agt cca gcc tga cctttctgca cactccagac aaacttccca   3667
Asp Val Thr Gly  Ser Pro Ala                                            
            1200                                                        

gacaagctcc tttgtgcctc tacgtggaga gggtgtggaa agttatcaca ttaaaagatg   3727

gaggatttaa aaaaaaaaaa aaaaaaaaaa aaaaaagaaa aaaaaaaaaa aa           3779


<210>  12
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg Leu  Gln Tyr Arg Ser Glu  Thr Met Ala 
    1175                 1180                 1185             


Tyr Lys  Gly Leu Val Trp Ser  Gln Asp Val Thr Gly  Ser Pro Ala 
    1190                 1195                 1200             


<210>  13
<211>  4633
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (656)..(1339)

<400>  13
gccctccatt gtctccacgg cggcgaggag cgccggcgag cgcagcccgg gaccgagcgg     60

ggcggcgcgg ctggcggggc cggcggcggc tgaagcgaga gcgcgacgcg acgcgaccgc    120

ggcttcccga gctgcgcctg gccgcccagc gccgcggccc gcccgaggcc tggaggggtc    180

cgggccgccg tccatggtcg cggcgtcctg aggcggggga cgcgcccggc gcccccggcc    240

ctcctccgcc tcctcccgcg gggcgggcgg cctcctccgg cgcctccccg cgcccgcccg    300

ccgctcgccg ccgcctccct ccctccttcc ctgcggctcc cccggctttc ggagcccggg    360

ggcggcctgt ggcgcgcgga gcccgcgccg gactgcgcct ctttggacct tgaggggaaa    420

catgcgtttg ccttggatcg tttgaaattc tgagtttggg atccccgccc gcccgcctgc    480

ctcttccgcc ccgcgggttt tttccttttt tccttttgct ttttttcctt ttctccctcc    540

gggtctcctt tttgactccc tcccccttta tgctcgccca gccctccccc tgctgctgag    600

aagtggggga gggtctcggc ctccaggttc ccgccccacc ggggcccggg cgagc atg     658
                                                             Met        
                                                             1          

ggg ggc aag cag agc acg gcg gcc cgc tcc cgg ggc ccc ttc ccg ggg      706
Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro Gly         
            5                   10                  15                  

gtc tcc acc gat gac agc gcc gtg ccg ccg ccg gga ggg gcg ccc cat      754
Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro His         
        20                  25                  30                      

ttc ggg cac tac cgg acg ggc ggc ggg gcc atg ggg ctg cgc agc cgc      802
Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser Arg         
    35                  40                  45                          

tcg gtc agc tcg gtg gca ggc atg ggc atg gac ccc agc acg gcc ggg      850
Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala Gly         
50                  55                  60                  65          

ggg gtg ccc ttt ggc ctc tac acc ccc gcc tcc cgg ggc acc ggc gac      898
Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly Asp         
                70                  75                  80              

tcc gag agg gcg ccc ggc ggc gga ggg tct gcg tcc gac tcc acc tat      946
Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr Tyr         
            85                  90                  95                  

gcc cat ggc aat ggt tac cag gag acg ggc ggc ggt cac cat aga gac      994
Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg Asp         
        100                 105                 110                     

ggg atg ctg tac ctg ggc tcc cga gcc tcg ctg gcg gat gct cta cct     1042
Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu Pro         
    115                 120                 125                         

ctg cac atc gca ccc agg tgg ttc agc tcg cat agt ggt ttc aag tgc     1090
Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys Cys         
130                 135                 140                 145         

ccc att tgc tcc aag tct gtg gct tct gac gag atg gaa atg cac ttt     1138
Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His Phe         
                150                 155                 160             

ata atg tgt ttg agc aaa cct cgc ctc tcc tac aac gat gat gtg ctg     1186
Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val Leu         
            165                 170                 175                 

act aaa gac gcg ggt gag tgt gtg atc tgc ctg gag gag ctg ctg cag     1234
Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu Gln         
        180                 185                 190                     

ggg gac acg ata gcc agg ctg ccc tgc ctg tgc atc tat cac aaa agc     1282
Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys Ser         
    195                 200                 205                         

tgc ata gac tcg tgg ttt gaa gtg aac aga tct tgt ccg gaa cac cct     1330
Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His Pro         
210                 215                 220                 225         

gcg gac tga cctgcgggct tgcttgctga ctcctctcaa agggacagag             1379
Ala Asp                                                                 
                                                                        

cgcccctgct ccagggagga ggctcaccgg accctggggc agagctgagc ttgggacacc   1439

agcgggaaca gggcacccct tctgcactga cttccagatc atggttctcc cttcctccct   1499

gaggacacca aattggatga gagcaagttt gagagaagaa tgaatcaact gctatccttc   1559

ccctcacccc tcagcccagg agggaaaggg cattttcttt ttcatctttg aaaggcattg   1619

tgggtctgtc tttaaagtgt ttacaaaaaa aaattatata aaaaaaaagt ctagtgtcga   1679

ctggtgtttt ccctcgtgat gtttacagct tgctgtttgc tgcccagcca taacccactc   1739

agtgacagac gaacacagct aaggcctcgc tgccagcctt ctgacggcgg gcgagcacac   1799

ggtctcttcc cctgccccaa ctggccctct ccaccaccaa cttctctact ttgggtttgt   1859

ttggtttttt ccctctattt ttctggctgg ttttttgctc ttttctcccc ttgagaccct   1919

aatatcttga cttcattgcc aaaaaacaac ccattgagaa ctttcttcct actgatccca   1979

tctcttttcc cttctttcct cctggttccg gtcagttcag aggatttaac aatcacaagt   2039

gtcctgcaaa aatgcctgaa cattattctt aggccctcgt ggattttttt tttcagaaaa   2099

cttaaacaaa aaaagactta ctaagaaata tgtacagcta cccctgtttt caggcactat   2159

gtttgagaac attttagcca ttgatgttca cacgtggcat cagcccatgc aagataggtt   2219

tctgtattta tatattaaaa tacaaaaaaa aacttataaa atgtttaaaa aaatgttcaa   2279

agcttgggag aaaagctttc ttcattagtc aaggtgtttt gatatggtat taaaatgtct   2339

aataaaagat ggcactgcgt gattttattt taatgaagtg ttatacaatc aagaaatggg   2399

ggcaagggcc tgccccccac tccctcacct acctccttag cattccttca ggctgctact   2459

cggggctcca ggtgtgtgaa ttggtcctca gatagtcagg cctgggtgga gggagtggca   2519

agtcaggcgt gcctcctaca agcttcctaa cctcttaagc atcatggaac cagtcagccc   2579

tctgtggagt cattgtgctg gacctctgaa aagatctgca ggggccaaga tgttgcagcc   2639

accggaggct gcaaggatgt gggttcttcc aggtgtgggc ccagcccccc tccttccagc   2699

ctttgctccc catcccacgt tccactcgcc ctgcctgttg ttcagtttgc gtctcagtgc   2759

tgactcacgg gcatgcttca ttgaggccca ggaagaggcc ctggtttggg gctgtgccag   2819

ctcagagccc ttgaaccaga accaactgct caggctcaca aaagttggca aaatgcgggc   2879

tgggcaggca gctcggggca gggagcagca gtgcaggcct ggcctgtgtc cccgtgccca   2939

gcgggctccc ggagcagcat tccagagcct cctgcagagc cagcgaagga aagctctaga   2999

gggagacgac tccaccgcct ctctgctctg acccttctca ggcccgcctg atgtgctgga   3059

ccatccccct gctgccacgg cccctggctc cgcagtcacc ctccatcaga tgcttccaga   3119

agcacctact ctgtgcaagg gcattcacaa caggccagtg ggcaaacgtg agccagggcc   3179

agcggagaaa cactaaagaa gactcggtgg ttcagagcct gggtctcagc gcgggacccg   3239

tctggggtga agaccttggg gctgttgtga gtcggtggca ggaacgtggg ctctagactg   3299

tgcattcagg ctctcctact tggcagaatg atcttgggga aacgacttca tctgaacttc   3359

agatatttca catgtgaagc ggggacaaaa ccatgcagct cagaggtccc tgtgggggct   3419

gggggagctg ccctgcaggt cttggcacat gcacagcagg ctccccatag ctttgtcacc   3479

acaaagggca ctgttctatt cacagcacct cctgcttctg cctggcaact gtgtctccct   3539

gtgctatatt taattccacc agcaaagctg gcgaggcagg gcccagccct gaaggagatc   3599

tccttgcctg acccctggac ctggaaatgg aggcttcatg tgcccgcctt ggcggcttaa   3659

gcctgctgct ttggcagtgc catgggtgag ccgagcagct gtgaggtggg tggggcaggg   3719

ctgtagccca cgccgggtgc tattccaggc tctaggggct ggtgctcatc cccaccccca   3779

gcgacttccg tcctacctgg catgctgcag ccctctgccg gctgtggtgt cctctgaatt   3839

tggacccagg ttgcctgctc ttgttgtggg ggtgggattg gggctgtctg tgtttcccag   3899

gtggagctca tgtttgtgat cctctatctg gacagctctc cagaatcctg tgttgcccct   3959

gttctgcctt tctgggatgg gagagaaggt gagggagccg gcgagcaggt tctaccctct   4019

ctgctaaggg cctagcacac tttgatgagg ttcctggacg tgagaccctc acaaagacca   4079

accattcctc taatagccat ttaacggtac tgcagttcat gggaaaatgt cctcattctt   4139

aggagataga tgctggatta tataggtgaa tgccttcaag aaatgtgtaa tttaattcca   4199

aatagttccc cccaaaatac acaaagcaaa taaggccaaa atgttcattg ttgaatctgc   4259

agtggctggt atttcagtga acagtgtact tgttctttca acttttctgt atgtttggaa   4319

tttttcttaa taaaagattg tgggaaatgg tcatttgctg agcgcctcct agttgccagg   4379

cactggaggg cgcatcaaag aagagtccta cccaggaggg agagcgcagc tgctgcagga   4439

ttctcgcctg gaagagtggg tggctggctg gctggctgga aggggagggg cgagagggct   4499

gtctcggtga tgagcacacg cgtgctgggg tggtttgggg agagggctga gatttgtcac   4559

cagtgagccc ttggcacggt ctctgctccc caccagggca gcacgggaca gaaacgtcac   4619

ggaggagtag cctc                                                     4633


<210>  14
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
1               5                   10                  15      


Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
            20                  25                  30          


His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
        35                  40                  45              


Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
    50                  55                  60                  


Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
65                  70                  75                  80  


Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                85                  90                  95      


Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
            100                 105                 110         


Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
        115                 120                 125             


Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
    130                 135                 140                 


Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
145                 150                 155                 160 


Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                165                 170                 175     


Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
            180                 185                 190         


Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
        195                 200                 205             


Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
    210                 215                 220                 


Pro Ala Asp 
225         


<210>  15
<211>  2907
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (78)..(542)

<400>  15
gctccaggaa gtgcgggggc tccagccgcc cggccggccg cgatgcattc tggggaagga     60

gcagcaccaa atccaag atg gcg gcc agc agg agg ctg atg aag gag ctt       110
                   Met Ala Ala Ser Arg Arg Leu Met Lys Glu Leu          
                   1               5                   10               

gaa gaa atc cgc aaa tgt ggg atg aaa aac ttc cgt aac atc cag gtt      158
Glu Glu Ile Arg Lys Cys Gly Met Lys Asn Phe Arg Asn Ile Gln Val         
            15                  20                  25                  

gat gaa gct aat tta ttg act tgg caa ggg ctt att gtt cct gac aac      206
Asp Glu Ala Asn Leu Leu Thr Trp Gln Gly Leu Ile Val Pro Asp Asn         
        30                  35                  40                      

cct cca tat gat aag gga gcc ttc aga atc gaa atc aac ttt cca gca      254
Pro Pro Tyr Asp Lys Gly Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala         
    45                  50                  55                          

gag tac cca ttc aaa cca ccg aag atc aca ttt aaa aca aag atc tat      302
Glu Tyr Pro Phe Lys Pro Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr         
60                  65                  70                  75          

cac cca aac atc gac gaa aag ggg cag gtc tgt ctg cca gta att agt      350
His Pro Asn Ile Asp Glu Lys Gly Gln Val Cys Leu Pro Val Ile Ser         
                80                  85                  90              

gcc gaa aac tgg aag cca gca acc aaa acc gac caa gta atc cag tcc      398
Ala Glu Asn Trp Lys Pro Ala Thr Lys Thr Asp Gln Val Ile Gln Ser         
            95                  100                 105                 

ctc ata gca ctg gtg aat gac ccc cag cct gag cac ccg ctt cgg gct      446
Leu Ile Ala Leu Val Asn Asp Pro Gln Pro Glu His Pro Leu Arg Ala         
        110                 115                 120                     

gac cta gct gaa gaa tac tct aag gac cgt aaa aaa ttc tgt aag aat      494
Asp Leu Ala Glu Glu Tyr Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn         
    125                 130                 135                         

gct gaa gag ttt aca aag aaa tat ggg gaa aag cga cct gtg gac taa      542
Ala Glu Glu Phe Thr Lys Lys Tyr Gly Glu Lys Arg Pro Val Asp             
140                 145                 150                             

aatctgccac gattggttcc agcaagtgtg agcagagacc ccgtgcagtg cattcagaca    602

ccccgcaaag caggactctg tggaaattga cacgtgccac cgcctggcgt tcgcttgtgg    662

cagttactaa ctttctacag ttttcttaat caaaagtggt ctaggtaacc tgtaaagaaa    722

ggattaaaaa tttaagatgt tctagttctg ctctctttgt tttaaaaatc actgcttcaa    782

tctacttcaa aagaatggtg tttcttttct tgtccaattt tatccaaaat cttcaagtta    842

catttaaccc ataaggttta aaaaaaagga aaaaaaacgg ttgtggttcc ctttcttccc    902

tacccttgcc actcccactt tctggcaccg agtttatttt tcacttactt acttccccag    962

accccgggct cgcctccaca aaggagaaga gactgccctg gcggtcctgg tggcttttct   1022

tagcatgtgt ggcactgttg cccagtgtgg gagttggttt aaattctcct gactccagtt   1082

tataacatcc ttttaaaaaa tttaaaaaca aacagccaca cccctcctcc agtccttctc   1142

ctcagttctt gtgtgaaact ccagctgatg ttaccacagt aacatcagtt aattgggcaa   1202

gccctgatgt cagtgtgtgt aactgacctc tggcctggcc tgcacagaga agccctataa   1262

tcacaggtct gtggtggccc cgaaatgggg ggcctgctag tcaggaggat gctgtgcaca   1322

ctgtgtgtga tgaatctcgc cagaaaggct cctgaggtcc caggttggca cttctccctg   1382

cagccattgt agaagatctg ctggtccttg caggcaaagc tacagccaga atgtccgttt   1442

gaaactccta gctcatctgt caccgagctt catccgaatg tgccacggag cttgctctcc   1502

acttcctccg tgcagtggcc ctgccacagc cctccctcgg cacactttga ccctttgtag   1562

gattggaatt agcaggactc ggctatttaa agcaccagtc tggggtcgcc tgggcccctg   1622

ctgaccccct cctccagagc agccagccca gcccgggaac aagacggact tcctctccct   1682

tcggactcac agcctttgca gagtcaagct ccacttgaag ctcactcagt aatatccttt   1742

caatgtgttt tatattgttt tgactgcctt tttttgtaga aataaaaatt gaccttagaa   1802

tttatcgtca gataaacttg taaagatttg aatattaatg tcttttcaag gcaaatggga   1862

ttgtccccgc actagtagag aatccatgtc gctctgacac cccaaggaag ccgacgatcc   1922

aaatgccgtg tgtcaccaac cccgcttctg ccactggcgg cttcccttct tggctcttgg   1982

gggggactag atcctgtgga gaagatgact taaactttgc tttttgtttt aattttaatt   2042

ctataacttg agatctttcc ggggcctaca ggcgtgtaag acagcttggt ctggtctgtg   2102

cagaagtggg gagtgatggg caggttcggc agcctaacat tgttcaggcg catggcccct   2162

gcggtgtgta cacgaactcg gcttcttttg tcctaggtac gccaagggca ggtttctgga   2222

gactcccttg tgcccgggat ggcaagggca ccgggctggc gtttccacat ctgtcttcat   2282

tagcagaaaa gtgatgatgg attttatttc actcacactc cagtttgtaa taaaatgcca   2342

aattctgtca gctatccaaa caagccacca tttgttcttg ttgcttctct ggatccagaa   2402

atgttgccat tcttggaaac tgtcccattg cttcgtattt ctgccaacgt agctctgcct   2462

gcctgtcaac ccctcactgc actctgctca tcacgggagg atacctgtgt gccggcagcc   2522

cctcagggac tctcagccct ggcactggca ccccagggtt ggccccgtca gcagaggctt   2582

ggctttcgag ccagtgggtg tctctccttt gggcctgggc ggcttgctcc tgccagccat   2642

gccttcaggg taggctctga gcaagctggc gaacagccct ggctgctcca aaaccaaaaa   2702

gctgggtcct ctggaggagg ggcgagctgt ggagcagcca cccactgctg ccccaagctc   2762

actcaggaat tcacacccgc ctggtttctt gaagtgtgct gggtccttcc ctctgctccc   2822

tactccccac cacggcagag aataggcttt ctaagatgct gcgatcccgt tctgctgccc   2882

gtaataaaaa tgctctcaga cactg                                         2907


<210>  16
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys 
1               5                   10                  15      


Cys Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu 
            20                  25                  30          


Leu Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys 
        35                  40                  45              


Gly Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp 
65                  70                  75                  80  


Glu Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys 
                85                  90                  95      


Pro Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val 
            100                 105                 110         


Asn Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu 
        115                 120                 125             


Tyr Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 


Lys Lys Tyr Gly Glu Lys Arg Pro Val Asp 
145                 150                 


