                         SEQUENCE LISTING

<110>  Copenhagen University
 
<120>  Modified peptides as potent inhibitors of the PSD-95/NMDA 
       receptor interaction

<130>  P80827341EP00

<160>  24    

<170>  PatentIn version 3.3

<210>  1
<211>  310
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(306)
<223>  HIS-PDZ1 DNA

<400>  1
atg cac cac cac cac cac ccg cgc gga tcc atg gaa tac gag gaa atc       48
Met His His His His His Pro Arg Gly Ser Met Glu Tyr Glu Glu Ile         
1               5                   10                  15              

aca ttg gaa agg ggt aac tca ggt ctg ggc ttc agc atc gca ggt ggc       96
Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly         
            20                  25                  30                  

act gac aac cca cac atc ggt gac gac cca tcc att ttc atc acc aag      144
Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys         
        35                  40                  45                      

atc att cct ggt ggg gct gcg gcc cag gat ggc cgc ctc agg gtc aac      192
Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn         
    50                  55                  60                          

gac agc atc ctg ttt gta aat gaa gtg gac gtg cgc gag gtg acc cac      240
Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His         
65                  70                  75                  80          

tca gcg gcg gtg gaa gcc ctc aaa gag gca ggc tcc atc gtt cgc ctc      288
Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu         
                85                  90                  95              

tat gtc atg cgc cgg tga attc                                         310
Tyr Val Met Arg Arg                                                     
            100                                                         


<210>  2
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His His His His His Pro Arg Gly Ser Met Glu Tyr Glu Glu Ile 
1               5                   10                  15      


Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly 
            20                  25                  30          


Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys 
        35                  40                  45              


Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn 
    50                  55                  60                  


Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His 
65                  70                  75                  80  


Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu 
                85                  90                  95      


Tyr Val Met Arg Arg 
            100     


<210>  3
<211>  322
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  HIS-PDZ2 DNA

<400>  3
atg cac cac cac cac cac ccg cgc gga tcc gct gag aag gtc atg gag       48
Met His His His His His Pro Arg Gly Ser Ala Glu Lys Val Met Glu         
1               5                   10                  15              

atc aag ctc atc aag ggg cct aaa ggt ctt ggc ttc agc atc gca ggg       96
Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly         
            20                  25                  30                  

ggc gta ggg aac cag cac atc cca gga gat aat agc atc tat gta aca      144
Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr         
        35                  40                  45                      

aag atc atc gaa ggg ggt gct gcc cac aag gat ggg agg ttg cag att      192
Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile         
    50                  55                  60                          

gga gac aag atc ctg gcg gtc aac agt gtg ggg cta gag gac gtc atg      240
Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met         
65                  70                  75                  80          

cat gaa gat gct gtg gca gcc ctg aag aac acg tat gat gtt gtc tac      288
His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr         
                85                  90                  95              

cta aag gtg gcc aag ccc agc aat gcc tga attc                         322
Leu Lys Val Ala Lys Pro Ser Asn Ala                                     
            100                 105                                     


<210>  4
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His His His His His Pro Arg Gly Ser Ala Glu Lys Val Met Glu 
1               5                   10                  15      


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
            20                  25                  30          


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
        35                  40                  45              


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
    50                  55                  60                  


Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
65                  70                  75                  80  


His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
                85                  90                  95      


Leu Lys Val Ala Lys Pro Ser Asn Ala 
            100                 105 


<210>  5
<211>  312
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(312)
<223>  HIS-PDZ3

<400>  5
atg cac cac cac cac cac ccg cgc gga tcc cga gaa ccg agg cga att       48
Met His His His His His Pro Arg Gly Ser Arg Glu Pro Arg Arg Ile         
1               5                   10                  15              

gtg atc cac cgg ggc tcc acg ggc ctg ggc ttc aac atc gtg ggt ggc       96
Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe Asn Ile Val Gly Gly         
            20                  25                  30                  

gag gac ggt gaa ggc atc ttc atc tcc ttt atc ctg gcc ggg ggc cct      144
Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro         
        35                  40                  45                      

gca gac ctc agt ggg gag ctg cgg aag ggg gac cag atc ctg tcg gtc      192
Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Gln Ile Leu Ser Val         
    50                  55                  60                          

aac ggt gtg gac ctc cga aat gcc agc cat gag cag gct gcc att gcc      240
Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu Gln Ala Ala Ile Ala         
65                  70                  75                  80          

ctg aag aat gcg ggt cag acg gtc acg atc atc gct cag tat aaa cca      288
Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro         
                85                  90                  95              

gaa gag tac agc cga ttc gag tga                                      312
Glu Glu Tyr Ser Arg Phe Glu                                             
            100                                                         


<210>  6
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  6

Met His His His His His Pro Arg Gly Ser Arg Glu Pro Arg Arg Ile 
1               5                   10                  15      


Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe Asn Ile Val Gly Gly 
            20                  25                  30          


Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro 
        35                  40                  45              


Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Gln Ile Leu Ser Val 
    50                  55                  60                  


Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu Gln Ala Ala Ile Ala 
65                  70                  75                  80  


Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro 
                85                  90                  95      


Glu Glu Tyr Ser Arg Phe Glu 
            100             


<210>  7
<211>  605
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(600)
<223>  HIS-PDZ1-2 DNA

<400>  7
atg cac cac cac cac cac ccg cgc gga tcc atg gaa tac gag gaa atc       48
Met His His His His His Pro Arg Gly Ser Met Glu Tyr Glu Glu Ile         
1               5                   10                  15              

aca ttg gaa agg ggt aac tca ggt ctg ggc ttc agc atc gca ggt ggc       96
Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly         
            20                  25                  30                  

act gac aac cca cac atc ggt gac gac cca tcc att ttc atc acc aag      144
Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys         
        35                  40                  45                      

atc att cct ggt ggg gct gcg gcc cag gat ggc cgc ctc agg gtc aac      192
Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn         
    50                  55                  60                          

gac agc atc ctg ttt gta aat gaa gtg gac gtg cgc gag gtg acc cac      240
Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His         
65                  70                  75                  80          

tca gcg gcg gtg gaa gcc ctc aaa gag gca ggc tcc atc gtt cgc ctc      288
Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu         
                85                  90                  95              

tat gtc atg cgc cgg aag ccc ccg gct gag aag gtc atg gag atc aag      336
Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys         
            100                 105                 110                 

ctc atc aag ggg cct aaa ggt ctt ggc ttc agc atc gca ggg ggc gta      384
Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val         
        115                 120                 125                     

ggg aac cag cac atc cca gga gat aat agc atc tat gta aca aag atc      432
Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile         
    130                 135                 140                         

atc gaa ggg ggt gct gcc cac aag gat ggg agg ttg cag att gga gac      480
Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp         
145                 150                 155                 160         

aag atc ctg gcg gtc aac agt gtg ggg cta gag gac gtc atg cat gaa      528
Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu         
                165                 170                 175             

gat gct gtg gca gcc ctg aag aac acg tat gat gtt gtc tac cta aag      576
Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys         
            180                 185                 190                 

gtg gcc aag ccc agc aat gcc tga attcg                                605
Val Ala Lys Pro Ser Asn Ala                                             
        195                                                             


<210>  8
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His His His His His Pro Arg Gly Ser Met Glu Tyr Glu Glu Ile 
1               5                   10                  15      


Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly 
            20                  25                  30          


Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys 
        35                  40                  45              


Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn 
    50                  55                  60                  


Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His 
65                  70                  75                  80  


Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu 
                85                  90                  95      


Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys 
            100                 105                 110         


Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val 
        115                 120                 125             


Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile 
    130                 135                 140                 


Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp 
145                 150                 155                 160 


Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu 
                165                 170                 175     


Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys 
            180                 185                 190         


Val Ala Lys Pro Ser Asn Ala 
        195                 


<210>  9
<211>  822
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(822)
<223>  GFP-NR2B DNA

<400>  9
atg gtg agc aag ggc gag gag ctg ttc acc ggg gtg gtg ccc atc ctg       48
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu         
1               5                   10                  15              

gtc gag ctg gac ggc gac gta aac ggc cac aag ttc agc gtg tcc ggc       96
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly         
            20                  25                  30                  

gag ggc gag ggc gat gcc acc tac ggc aag ctg acc ctg aag ttc atc      144
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile         
        35                  40                  45                      

tgc acc acc ggc aag ctg ccc gtg ccc tgg ccc acc ctc gtg acc acc      192
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr         
    50                  55                  60                          

ctg agc tac ggc gtg cag tgc ttc agc cgc tac ccc gac cac atg aag      240
Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys         
65                  70                  75                  80          

cag cac gac ttc ttc aag tcc gcc atg ccc gaa ggc tac gtc cag gag      288
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu         
                85                  90                  95              

cgc acc atc ttc ttc aag gac gac ggc aac tac aag acc cgc gcc gag      336
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu         
            100                 105                 110                 

gtg aag ttc gag ggc gac acc ctg gtg aac cgc atc gag ctg aag ggc      384
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly         
        115                 120                 125                     

atc gac ttc aag gag gac ggc aac atc ctg ggg cac aag ctg gag tac      432
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr         
    130                 135                 140                         

aac tac aac agc cac aac gtc tat atc atg gcc gac aag cag aag aac      480
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn         
145                 150                 155                 160         

ggc atc aag gtg aac ttc aag atc cgc cac aac atc gag gac ggc agc      528
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser         
                165                 170                 175             

gtg cag ctc gcc gac cac tac cag cag aac acc ccc atc ggc gac ggc      576
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly         
            180                 185                 190                 

ccc gtg ctg ctg ccc gac aac cac tac ctg agc acc cag tcc gcc ctg      624
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu         
        195                 200                 205                     

agc aaa gac ccc aac gag aag cgc gat cac atg gtc ctg ctg gag ttc      672
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe         
    210                 215                 220                         

gtg acc gcc gcc ggg atc act ctc ggc atg gac gag ctg tac aag tcc      720
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser         
225                 230                 235                 240         

gga ctc aga tct ggc gag ctc tcg aga att ctc acg cgt ctg cag gat      768
Gly Leu Arg Ser Gly Glu Leu Ser Arg Ile Leu Thr Arg Leu Gln Asp         
                245                 250                 255             

atc aag ctt gga cat gtt tat gag aaa ctt tct agt att gag tct gat      816
Ile Lys Leu Gly His Val Tyr Glu Lys Leu Ser Ser Ile Glu Ser Asp         
            260                 265                 270                 

gtc tga                                                              822
Val                                                                     
                                                                        


<210>  10
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Gly Glu Leu Ser Arg Ile Leu Thr Arg Leu Gln Asp 
                245                 250                 255     


Ile Lys Leu Gly His Val Tyr Glu Lys Leu Ser Ser Ile Glu Ser Asp 
            260                 265                 270         


Val 
    


<210>  11
<211>  822
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(822)
<223>  GRF-NR2B AA DNA (mutant)

<400>  11
atg gtg agc aag ggc gag gag ctg ttc acc ggg gtg gtg ccc atc ctg       48
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu         
1               5                   10                  15              

gtc gag ctg gac ggc gac gta aac ggc cac aag ttc agc gtg tcc ggc       96
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly         
            20                  25                  30                  

gag ggc gag ggc gat gcc acc tac ggc aag ctg acc ctg aag ttc atc      144
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile         
        35                  40                  45                      

tgc acc acc ggc aag ctg ccc gtg ccc tgg ccc acc ctc gtg acc acc      192
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr         
    50                  55                  60                          

ctg agc tac ggc gtg cag tgc ttc agc cgc tac ccc gac cac atg aag      240
Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys         
65                  70                  75                  80          

cag cac gac ttc ttc aag tcc gcc atg ccc gaa ggc tac gtc cag gag      288
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu         
                85                  90                  95              

cgc acc atc ttc ttc aag gac gac ggc aac tac aag acc cgc gcc gag      336
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu         
            100                 105                 110                 

gtg aag ttc gag ggc gac acc ctg gtg aac cgc atc gag ctg aag ggc      384
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly         
        115                 120                 125                     

atc gac ttc aag gag gac ggc aac atc ctg ggg cac aag ctg gag tac      432
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr         
    130                 135                 140                         

aac tac aac agc cac aac gtc tat atc atg gcc gac aag cag aag aac      480
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn         
145                 150                 155                 160         

ggc atc aag gtg aac ttc aag atc cgc cac aac atc gag gac ggc agc      528
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser         
                165                 170                 175             

gtg cag ctc gcc gac cac tac cag cag aac acc ccc atc ggc gac ggc      576
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly         
            180                 185                 190                 

ccc gtg ctg ctg ccc gac aac cac tac ctg agc acc cag tcc gcc ctg      624
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu         
        195                 200                 205                     

agc aaa gac ccc aac gag aag cgc gat cac atg gtc ctg ctg gag ttc      672
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe         
    210                 215                 220                         

gtg acc gcc gcc ggg atc act ctc ggc atg gac gag ctg tac aag tcc      720
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser         
225                 230                 235                 240         

gga ctc aga tct ggc gag ctc tcg aga att ctc acg cgt ctg cag gat      768
Gly Leu Arg Ser Gly Glu Leu Ser Arg Ile Leu Thr Arg Leu Gln Asp         
                245                 250                 255             

atc aag ctt gga cat gtt tat gag aaa ctt tct agt att gag gct gat      816
Ile Lys Leu Gly His Val Tyr Glu Lys Leu Ser Ser Ile Glu Ala Asp         
            260                 265                 270                 

gcc tga                                                              822
Ala                                                                     
                                                                        


<210>  12
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Gly Glu Leu Ser Arg Ile Leu Thr Arg Leu Gln Asp 
                245                 250                 255     


Ile Lys Leu Gly His Val Tyr Glu Lys Leu Ser Ser Ile Glu Ala Asp 
            260                 265                 270         


Ala 
    


<210>  13
<211>  1074
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1074)
<223>  GFP-PDZ2 DNA

<400>  13
atg gtg agc aag ggc gag gag ctg ttc acc ggg gtg gtg ccc atc ctg       48
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu         
1               5                   10                  15              

gtc gag ctg gac ggc gac gta aac ggc cac aag ttc agc gtg tcc ggc       96
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly         
            20                  25                  30                  

gag ggc gag ggc gat gcc acc tac ggc aag ctg acc ctg aag ttc atc      144
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile         
        35                  40                  45                      

tgc acc acc ggc aag ctg ccc gtg ccc tgg ccc acc ctc gtg acc acc      192
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr         
    50                  55                  60                          

ctg agc tac ggc gtg cag tgc ttc agc cgc tac ccc gac cac atg aag      240
Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys         
65                  70                  75                  80          

cag cac gac ttc ttc aag tcc gcc atg ccc gaa ggc tac gtc cag gag      288
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu         
                85                  90                  95              

cgc acc atc ttc ttc aag gac gac ggc aac tac aag acc cgc gcc gag      336
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu         
            100                 105                 110                 

gtg aag ttc gag ggc gac acc ctg gtg aac cgc atc gag ctg aag ggc      384
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly         
        115                 120                 125                     

atc gac ttc aag gag gac ggc aac atc ctg ggg cac aag ctg gag tac      432
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr         
    130                 135                 140                         

aac tac aac agc cac aac gtc tat atc atg gcc gac aag cag aag aac      480
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn         
145                 150                 155                 160         

ggc atc aag gtg aac ttc aag atc cgc cac aac atc gag gac ggc agc      528
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser         
                165                 170                 175             

gtg cag ctc gcc gac cac tac cag cag aac acc ccc atc ggc gac ggc      576
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly         
            180                 185                 190                 

ccc gtg ctg ctg ccc gac aac cac tac ctg agc acc cag tcc gcc ctg      624
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu         
        195                 200                 205                     

agc aaa gac ccc aac gag aag cgc gat cac atg gtc ctg ctg gag ttc      672
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe         
    210                 215                 220                         

gtg acc gcc gcc ggg atc act ctc ggc atg gac gag ctg tac aag tcc      720
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser         
225                 230                 235                 240         

gga ctc aga tct ggc gag ctc tcg aga att ctc acg cgt ctg cag gat      768
Gly Leu Arg Ser Gly Glu Leu Ser Arg Ile Leu Thr Arg Leu Gln Asp         
                245                 250                 255             

atc aag ctt atg cgc cgg aag ccc ccg gct gag aag gtc atg gag atc      816
Ile Lys Leu Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile         
            260                 265                 270                 

aag ctc atc aag ggg cct aaa ggt ctt ggc ttc agc atc gca ggg ggc      864
Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly         
        275                 280                 285                     

gta ggg aac cag cac atc cca gga gat aat agc atc tat gta aca aag      912
Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys         
    290                 295                 300                         

atc atc gaa ggg ggt gct gcc cac aag gat ggg agg ttg cag att gga      960
Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly         
305                 310                 315                 320         

gac aag atc ctg gcg gtc aac agt gtg ggg cta gag gac gtc atg cat     1008
Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His         
                325                 330                 335             

gaa gat gct gtg gca gcc ctg aag aac acg tat gat gtt gtc tac cta     1056
Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu         
            340                 345                 350                 

aag gtg gcc aag ccc tag                                             1074
Lys Val Ala Lys Pro                                                     
        355                                                             


<210>  14
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Gly Glu Leu Ser Arg Ile Leu Thr Arg Leu Gln Asp 
                245                 250                 255     


Ile Lys Leu Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile 
            260                 265                 270         


Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly 
        275                 280                 285             


Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys 
    290                 295                 300                 


Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly 
305                 310                 315                 320 


Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His 
                325                 330                 335     


Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu 
            340                 345                 350         


Lys Val Ala Lys Pro 
        355         


<210>  15
<211>  1050
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1050)
<223>  PDZ2-GFP DNA

<400>  15
atg cgc cgg aag ccc ccg gct gag aag gtc atg gag atc aag ctc atc       48
Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile         
1               5                   10                  15              

aag ggg cct aaa ggt ctt ggc ttc agc atc gca ggg ggc gta ggg aac       96
Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn         
            20                  25                  30                  

cag cac atc cca gga gat aat agc atc tat gta aca aag atc atc gaa      144
Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu         
        35                  40                  45                      

ggg ggt gct gcc cac aag gat ggg agg ttg cag att gga gac aag atc      192
Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile         
    50                  55                  60                          

ctg gcg gtc aac agt gtg ggg cta gag gac gtc atg cat gaa gat gct      240
Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala         
65                  70                  75                  80          

gtg gca gcc ctg aag aac acg tat gat gtt gtc tac cta aag gtg gcc      288
Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala         
                85                  90                  95              

aag ccc ggt acc gcg ggc ccg gga tcc cca ccg gtc gcc acc atg gtg      336
Lys Pro Gly Thr Ala Gly Pro Gly Ser Pro Pro Val Ala Thr Met Val         
            100                 105                 110                 

agc aag ggc gag gag ctg ttc acc ggg gtg gtg ccc atc ctg gtc gag      384
Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu         
        115                 120                 125                     

ctg gac ggc gac gta aac ggc cac aag ttc agc gtg tcc ggc gag ggc      432
Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly         
    130                 135                 140                         

gag ggc gat gcc acc tac ggc aag ctg acc ctg aag ttc atc tgc acc      480
Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr         
145                 150                 155                 160         

acc ggc aag ctg ccc gtg ccc tgg ccc acc ctc gtg acc acc ctg agc      528
Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser         
                165                 170                 175             

tac ggc gtg cag tgc ttc agc cgc tac ccc gac cac atg aag cag cac      576
Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His         
            180                 185                 190                 

gac ttc ttc aag tcc gcc atg ccc gaa ggc tac gtc cag gag cgc acc      624
Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr         
        195                 200                 205                     

atc ttc ttc aag gac gac ggc aac tac aag acc cgc gcc gag gtg aag      672
Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys         
    210                 215                 220                         

ttc gag ggc gac acc ctg gtg aac cgc atc gag ctg aag ggc atc gac      720
Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp         
225                 230                 235                 240         

ttc aag gag gac ggc aac atc ctg ggg cac aag ctg gag tac aac tac      768
Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr         
                245                 250                 255             

aac agc cac aac gtc tat atc atg gcc gac aag cag aag aac ggc atc      816
Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile         
            260                 265                 270                 

aag gtg aac ttc aag atc cgc cac aac atc gag gac ggc agc gtg cag      864
Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln         
        275                 280                 285                     

ctc gcc gac cac tac cag cag aac acc ccc atc ggc gac ggc ccc gtg      912
Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val         
    290                 295                 300                         

ctg ctg ccc gac aac cac tac ctg agc acc cag tcc gcc ctg agc aaa      960
Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys         
305                 310                 315                 320         

gac ccc aac gag aag cgc gat cac atg gtc ctg ctg gag ttc gtg acc     1008
Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr         
                325                 330                 335             

gcc gcc ggg atc act ctc ggc atg gac gag ctg tac aag taa             1050
Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys                     
            340                 345                                     


<210>  16
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile 
1               5                   10                  15      


Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn 
            20                  25                  30          


Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu 
        35                  40                  45              


Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile 
    50                  55                  60                  


Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala 
65                  70                  75                  80  


Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala 
                85                  90                  95      


Lys Pro Gly Thr Ala Gly Pro Gly Ser Pro Pro Val Ala Thr Met Val 
            100                 105                 110         


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
        115                 120                 125             


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
    130                 135                 140                 


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
145                 150                 155                 160 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
                165                 170                 175     


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
            180                 185                 190         


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
        195                 200                 205             


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
    210                 215                 220                 


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
225                 230                 235                 240 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
                245                 250                 255     


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
            260                 265                 270         


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
        275                 280                 285             


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
    290                 295                 300                 


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
305                 310                 315                 320 


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
                325                 330                 335     


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            340                 345                 


<210>  17
<211>  1032
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1032)
<223>  RLuc-NR2B DNA

<400>  17
atg acc agc aag gtg tac gac ccc gag cag agg aag agg atg atc acc       48
Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr         
1               5                   10                  15              

ggc ccc cag tgg tgg gcc agg tgc aag cag atg aac gtg ctg gac agc       96
Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser         
            20                  25                  30                  

ttc atc aac tac tac gac agc gag aag cac gcc gag aac gcc gtg atc      144
Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile         
        35                  40                  45                      

ttc ctg cac ggc aac gcc gct agc agc tac ctg tgg agg cac gtg gtg      192
Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val         
    50                  55                  60                          

ccc cac atc gag ccc gtg gcc agg tgc atc atc ccc gat ctg atc ggc      240
Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly         
65                  70                  75                  80          

atg ggc aag agc ggc aag agc ggc aac ggc agc tac agg ctg ctg gac      288
Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp         
                85                  90                  95              

cac tac aag tac ctg acc gcc tgg ttc gag ctc ctg aac ctg ccc aag      336
His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys         
            100                 105                 110                 

aag atc atc ttc gtg ggc cac gac tgg ggc gcc tgc ctg gcc ttc cac      384
Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His         
        115                 120                 125                     

tac agc tac gag cac cag gac aag atc aag gcc atc gtg cac gcc gag      432
Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu         
    130                 135                 140                         

agc gtg gtg gac gtg atc gag agc tgg gac gag tgg cca gac atc gag      480
Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu         
145                 150                 155                 160         

gag gac atc gcc ctg atc aag agc gag gag ggc gag aag atg gtg ctg      528
Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu         
                165                 170                 175             

gag aac aac ttc ttc gtg gag acc atg ctg ccc agc aag atc atg aga      576
Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg         
            180                 185                 190                 

aag ctg gag ccc gag gag ttc gcc gcc tac ctg gag ccc ttc aag gag      624
Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu         
        195                 200                 205                     

aag ggc gag gtg aga aga ccc acc ctg agc tgg ccc aga gag atc ccc      672
Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro         
    210                 215                 220                         

ctg gtg aag ggc ggc aag ccc gac gtg gtg cag atc gtg aga aac tac      720
Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr         
225                 230                 235                 240         

aac gcc tac ctg aga gcc agc gac gac ctg ccc aag atg ttc atc gag      768
Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu         
                245                 250                 255             

agc gac ccc ggc ttc ttc agc aac gcc atc gtg gag ggc gcc aag aag      816
Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys         
            260                 265                 270                 

ttc ccc aac acc gag ttc gtg aag gtg aag ggc ctg cac ttc agc cag      864
Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln         
        275                 280                 285                     

gag gac gcc ccc gac gag atg ggc aag tac atc aag agc ttc gtg gag      912
Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu         
    290                 295                 300                         

aga gtg ctg aag aac gag cag ggg gat ctc ggc gag ctc tcg aga att      960
Arg Val Leu Lys Asn Glu Gln Gly Asp Leu Gly Glu Leu Ser Arg Ile         
305                 310                 315                 320         

ctc acg cgt ctg cag gat atc aag ctt gga cat gtt tat gag aaa ctt     1008
Leu Thr Arg Leu Gln Asp Ile Lys Leu Gly His Val Tyr Glu Lys Leu         
                325                 330                 335             

tct agt att gag tct gat gtc tga                                     1032
Ser Ser Ile Glu Ser Asp Val                                             
            340                                                         


<210>  18
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln Gly Asp Leu Gly Glu Leu Ser Arg Ile 
305                 310                 315                 320 


Leu Thr Arg Leu Gln Asp Ile Lys Leu Gly His Val Tyr Glu Lys Leu 
                325                 330                 335     


Ser Ser Ile Glu Ser Asp Val 
            340             


<210>  19
<211>  1032
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1032)
<223>  RLuc-NR2B AA DNA (mutant)

<400>  19
atg acc agc aag gtg tac gac ccc gag cag agg aag agg atg atc acc       48
Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr         
1               5                   10                  15              

ggc ccc cag tgg tgg gcc agg tgc aag cag atg aac gtg ctg gac agc       96
Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser         
            20                  25                  30                  

ttc atc aac tac tac gac agc gag aag cac gcc gag aac gcc gtg atc      144
Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile         
        35                  40                  45                      

ttc ctg cac ggc aac gcc gct agc agc tac ctg tgg agg cac gtg gtg      192
Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val         
    50                  55                  60                          

ccc cac atc gag ccc gtg gcc agg tgc atc atc ccc gat ctg atc ggc      240
Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly         
65                  70                  75                  80          

atg ggc aag agc ggc aag agc ggc aac ggc agc tac agg ctg ctg gac      288
Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp         
                85                  90                  95              

cac tac aag tac ctg acc gcc tgg ttc gag ctc ctg aac ctg ccc aag      336
His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys         
            100                 105                 110                 

aag atc atc ttc gtg ggc cac gac tgg ggc gcc tgc ctg gcc ttc cac      384
Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His         
        115                 120                 125                     

tac agc tac gag cac cag gac aag atc aag gcc atc gtg cac gcc gag      432
Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu         
    130                 135                 140                         

agc gtg gtg gac gtg atc gag agc tgg gac gag tgg cca gac atc gag      480
Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu         
145                 150                 155                 160         

gag gac atc gcc ctg atc aag agc gag gag ggc gag aag atg gtg ctg      528
Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu         
                165                 170                 175             

gag aac aac ttc ttc gtg gag acc atg ctg ccc agc aag atc atg aga      576
Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg         
            180                 185                 190                 

aag ctg gag ccc gag gag ttc gcc gcc tac ctg gag ccc ttc aag gag      624
Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu         
        195                 200                 205                     

aag ggc gag gtg aga aga ccc acc ctg agc tgg ccc aga gag atc ccc      672
Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro         
    210                 215                 220                         

ctg gtg aag ggc ggc aag ccc gac gtg gtg cag atc gtg aga aac tac      720
Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr         
225                 230                 235                 240         

aac gcc tac ctg aga gcc agc gac gac ctg ccc aag atg ttc atc gag      768
Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu         
                245                 250                 255             

agc gac ccc ggc ttc ttc agc aac gcc atc gtg gag ggc gcc aag aag      816
Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys         
            260                 265                 270                 

ttc ccc aac acc gag ttc gtg aag gtg aag ggc ctg cac ttc agc cag      864
Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln         
        275                 280                 285                     

gag gac gcc ccc gac gag atg ggc aag tac atc aag agc ttc gtg gag      912
Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu         
    290                 295                 300                         

aga gtg ctg aag aac gag cag ggg gat ctc ggc gag ctc tcg aga att      960
Arg Val Leu Lys Asn Glu Gln Gly Asp Leu Gly Glu Leu Ser Arg Ile         
305                 310                 315                 320         

ctc acg cgt ctg cag gat atc aag ctt gga cat gtt tat gag aaa ctt     1008
Leu Thr Arg Leu Gln Asp Ile Lys Leu Gly His Val Tyr Glu Lys Leu         
                325                 330                 335             

tct agt att gag gct gat gcc tga                                     1032
Ser Ser Ile Glu Ala Asp Ala                                             
            340                                                         


<210>  20
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln Gly Asp Leu Gly Glu Leu Ser Arg Ile 
305                 310                 315                 320 


Leu Thr Arg Leu Gln Asp Ile Lys Leu Gly His Val Tyr Glu Lys Leu 
                325                 330                 335     


Ser Ser Ile Glu Ala Asp Ala 
            340             


<210>  21
<211>  1284
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1284)
<223>  RLuc-PDR2 DNA

<400>  21
atg acc agc aag gtg tac gac ccc gag cag agg aag agg atg atc acc       48
Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr         
1               5                   10                  15              

ggc ccc cag tgg tgg gcc agg tgc aag cag atg aac gtg ctg gac agc       96
Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser         
            20                  25                  30                  

ttc atc aac tac tac gac agc gag aag cac gcc gag aac gcc gtg atc      144
Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile         
        35                  40                  45                      

ttc ctg cac ggc aac gcc gct agc agc tac ctg tgg agg cac gtg gtg      192
Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val         
    50                  55                  60                          

ccc cac atc gag ccc gtg gcc agg tgc atc atc ccc gat ctg atc ggc      240
Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly         
65                  70                  75                  80          

atg ggc aag agc ggc aag agc ggc aac ggc agc tac agg ctg ctg gac      288
Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp         
                85                  90                  95              

cac tac aag tac ctg acc gcc tgg ttc gag ctc ctg aac ctg ccc aag      336
His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys         
            100                 105                 110                 

aag atc atc ttc gtg ggc cac gac tgg ggc gcc tgc ctg gcc ttc cac      384
Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His         
        115                 120                 125                     

tac agc tac gag cac cag gac aag atc aag gcc atc gtg cac gcc gag      432
Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu         
    130                 135                 140                         

agc gtg gtg gac gtg atc gag agc tgg gac gag tgg cca gac atc gag      480
Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu         
145                 150                 155                 160         

gag gac atc gcc ctg atc aag agc gag gag ggc gag aag atg gtg ctg      528
Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu         
                165                 170                 175             

gag aac aac ttc ttc gtg gag acc atg ctg ccc agc aag atc atg aga      576
Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg         
            180                 185                 190                 

aag ctg gag ccc gag gag ttc gcc gcc tac ctg gag ccc ttc aag gag      624
Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu         
        195                 200                 205                     

aag ggc gag gtg aga aga ccc acc ctg agc tgg ccc aga gag atc ccc      672
Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro         
    210                 215                 220                         

ctg gtg aag ggc ggc aag ccc gac gtg gtg cag atc gtg aga aac tac      720
Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr         
225                 230                 235                 240         

aac gcc tac ctg aga gcc agc gac gac ctg ccc aag atg ttc atc gag      768
Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu         
                245                 250                 255             

agc gac ccc ggc ttc ttc agc aac gcc atc gtg gag ggc gcc aag aag      816
Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys         
            260                 265                 270                 

ttc ccc aac acc gag ttc gtg aag gtg aag ggc ctg cac ttc agc cag      864
Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln         
        275                 280                 285                     

gag gac gcc ccc gac gag atg ggc aag tac atc aag agc ttc gtg gag      912
Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu         
    290                 295                 300                         

aga gtg ctg aag aac gag cag ggg gat ctc ggc gag ctc tcg aga att      960
Arg Val Leu Lys Asn Glu Gln Gly Asp Leu Gly Glu Leu Ser Arg Ile         
305                 310                 315                 320         

ctc acg cgt ctg cag gat atc aag ctt atg cgc cgg aag ccc ccg gct     1008
Leu Thr Arg Leu Gln Asp Ile Lys Leu Met Arg Arg Lys Pro Pro Ala         
                325                 330                 335             

gag aag gtc atg gag atc aag ctc atc aag ggg cct aaa ggt ctt ggc     1056
Glu Lys Val Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly         
            340                 345                 350                 

ttc agc atc gca ggg ggc gta ggg aac cag cac atc cca gga gat aat     1104
Phe Ser Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn         
        355                 360                 365                     

agc atc tat gta aca aag atc atc gaa ggg ggt gct gcc cac aag gat     1152
Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp         
    370                 375                 380                         

ggg agg ttg cag att gga gac aag atc ctg gcg gtc aac agt gtg ggg     1200
Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly         
385                 390                 395                 400         

cta gag gac gtc atg cat gaa gat gct gtg gca gcc ctg aag aac acg     1248
Leu Glu Asp Val Met His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr         
                405                 410                 415             

tat gat gtt gtc tac cta aag gtg gcc aag ccc tag                     1284
Tyr Asp Val Val Tyr Leu Lys Val Ala Lys Pro                             
            420                 425                                     


<210>  22
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln Gly Asp Leu Gly Glu Leu Ser Arg Ile 
305                 310                 315                 320 


Leu Thr Arg Leu Gln Asp Ile Lys Leu Met Arg Arg Lys Pro Pro Ala 
                325                 330                 335     


Glu Lys Val Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly 
            340                 345                 350         


Phe Ser Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn 
        355                 360                 365             


Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp 
    370                 375                 380                 


Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly 
385                 390                 395                 400 


Leu Glu Asp Val Met His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr 
                405                 410                 415     


Tyr Asp Val Val Tyr Leu Lys Val Ala Lys Pro 
            420                 425         


<210>  23
<211>  1269
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1269)
<223>  PDF2-RLuc DNA

<400>  23
atg cgc cgg aag ccc ccg gct gag aag gtc atg gag atc aag ctc atc       48
Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile         
1               5                   10                  15              

aag ggg cct aaa ggt ctt ggc ttc agc atc gca ggg ggc gta ggg aac       96
Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn         
            20                  25                  30                  

cag cac atc cca gga gat aat agc atc tat gta aca aag atc atc gaa      144
Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu         
        35                  40                  45                      

ggg ggt gct gcc cac aag gat ggg agg ttg cag att gga gac aag atc      192
Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile         
    50                  55                  60                          

ctg gcg gtc aac agt gtg ggg cta gag gac gtc atg cat gaa gat gct      240
Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala         
65                  70                  75                  80          

gtg gca gcc ctg aag aac acg tat gat gtt gtc tac cta aag gtg gcc      288
Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala         
                85                  90                  95              

aag ccc ggt acc gcg ggc ccg gga tcc cca ccg gct aga gcc acc atg      336
Lys Pro Gly Thr Ala Gly Pro Gly Ser Pro Pro Ala Arg Ala Thr Met         
            100                 105                 110                 

acc agc aag gtg tac gac ccc gag cag agg aag agg atg atc acc ggc      384
Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly         
        115                 120                 125                     

ccc cag tgg tgg gcc agg tgc aag cag atg aac gtg ctg gac agc ttc      432
Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe         
    130                 135                 140                         

atc aac tac tac gac agc gag aag cac gcc gag aac gcc gtg atc ttc      480
Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe         
145                 150                 155                 160         

ctg cac ggc aac gcc gct agc agc tac ctg tgg agg cac gtg gtg ccc      528
Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro         
                165                 170                 175             

cac atc gag ccc gtg gcc agg tgc atc atc ccc gat ctg atc ggc atg      576
His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met         
            180                 185                 190                 

ggc aag agc ggc aag agc ggc aac ggc agc tac agg ctg ctg gac cac      624
Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His         
        195                 200                 205                     

tac aag tac ctg acc gcc tgg ttc gag ctc ctg aac ctg ccc aag aag      672
Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys         
    210                 215                 220                         

atc atc ttc gtg ggc cac gac tgg ggc gcc tgc ctg gcc ttc cac tac      720
Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His Tyr         
225                 230                 235                 240         

agc tac gag cac cag gac aag atc aag gcc atc gtg cac gcc gag agc      768
Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser         
                245                 250                 255             

gtg gtg gac gtg atc gag agc tgg gac gag tgg cca gac atc gag gag      816
Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu         
            260                 265                 270                 

gac atc gcc ctg atc aag agc gag gag ggc gag aag atg gtg ctg gag      864
Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu         
        275                 280                 285                     

aac aac ttc ttc gtg gag acc atg ctg ccc agc aag atc atg aga aag      912
Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg Lys         
    290                 295                 300                         

ctg gag ccc gag gag ttc gcc gcc tac ctg gag ccc ttc aag gag aag      960
Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys         
305                 310                 315                 320         

ggc gag gtg aga aga ccc acc ctg agc tgg ccc aga gag atc ccc ctg     1008
Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu         
                325                 330                 335             

gtg aag ggc ggc aag ccc gac gtg gtg cag atc gtg aga aac tac aac     1056
Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn         
            340                 345                 350                 

gcc tac ctg aga gcc agc gac gac ctg ccc aag atg ttc atc gag agc     1104
Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser         
        355                 360                 365                     

gac ccc ggc ttc ttc agc aac gcc atc gtg gag ggc gcc aag aag ttc     1152
Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe         
    370                 375                 380                         

ccc aac acc gag ttc gtg aag gtg aag ggc ctg cac ttc agc cag gag     1200
Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu         
385                 390                 395                 400         

gac gcc ccc gac gag atg ggc aag tac atc aag agc ttc gtg gag aga     1248
Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg         
                405                 410                 415             

gtg ctg aag aac gag cag taa                                         1269
Val Leu Lys Asn Glu Gln                                                 
            420                                                         


<210>  24
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile 
1               5                   10                  15      


Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn 
            20                  25                  30          


Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu 
        35                  40                  45              


Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile 
    50                  55                  60                  


Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala 
65                  70                  75                  80  


Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala 
                85                  90                  95      


Lys Pro Gly Thr Ala Gly Pro Gly Ser Pro Pro Ala Arg Ala Thr Met 
            100                 105                 110         


Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
        115                 120                 125             


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
    130                 135                 140                 


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
145                 150                 155                 160 


Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro 
                165                 170                 175     


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
            180                 185                 190         


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
        195                 200                 205             


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
    210                 215                 220                 


Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His Tyr 
225                 230                 235                 240 


Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser 
                245                 250                 255     


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
            260                 265                 270         


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
        275                 280                 285             


Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg Lys 
    290                 295                 300                 


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
305                 310                 315                 320 


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
                325                 330                 335     


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
            340                 345                 350         


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser 
        355                 360                 365             


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
    370                 375                 380                 


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu 
385                 390                 395                 400 


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
                405                 410                 415     


Val Leu Lys Asn Glu Gln 
            420         


