                         SEQUENCE LISTING

<110>  Blais, Normand
       Rheault, Patrick
 
<120>  CHIMERIC ANTIGENS

<130>  VU63077

<150>  61/081,888
<151>  2008-07-18

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1697
<212>  DNA
<213>  respiratory syncytial virus

<400>  1
atggagttgc taatcctcaa agcaaatgca attaccacaa tcctcactgc agtcacattt       60

gttttgcttc tggtcaaaac atcactgaag aattttatca atcaacatgc agtgcagtag      120

caaaggctat cttagtgctc tgagaactgg ttggtatacc agtgttataa ctatagatta      180

agtaatatca aggaaaataa gtgtaatgga acagatgcta aggtaaaatt gataaacaag      240

aattagataa atataaaaat gctgtaacag aattgcagtt gctcatgcaa agcacccagc      300

aacaaacaat cgagccagaa gagaactacc aaggtttatg aattatacac tcaaaatgcc      360

aaaaaaacca atgtaacatt aagcaagaaa aggaaaagaa gatttcttgg tttttgttag      420

gtgttggatc tgcaatcgcc agtggcgttg ctgtatctaa ggtcctgcac ctgaagggga      480

agtgaacaag atcaaaagtg ctctactatc cacaaacaag gctgtagtca gttatcaaat      540

ggagttagtg tcttaaccag caaagtgtta gacctcaaaa actatataga aaacaattgt      600

tacctattgt gaacaagcaa agctgcagca tatcaaatat agcaactgta tagagttcca      660

acaaaagaac aacagactac tagagattac cagggaattt agtgttaagc aggtgtaact      720

acacctgtaa gcacttacat gttaactaat agtgaattat tgtcattatc aatgatatgc      780

ctataacaaa tgatcagaaa aagttaatgt ccaacaatgt tcaaatgtta gacagcaaag      840

ttactctatc atgtccataa taaaagagga agtcttagca tatgtgtaca attaccacta      900

tatggtgtta tagatacacc ctgttggaaa ctacacacat ccccctatgt acaaccaaca      960

caaaagaagg gtccaacatc tgtttaacaa gaactgacag aggtggtact gtgacaatgc     1020

aggatcagta tctttcttcc cacaagctga aacatgtaaa gtcaatcaaa tcgagtattt     1080

tgtgacacaa tgaacagttt aacattacca agtgaagtaa actctgcaat gttgacatat     1140

tcaaccccaa atatgattgt aaaattatga cttcaaaaac gatgtaagca gctccgttat     1200

cacatctcta ggagccattg tgtcatgcta tggcaaaaca aatgtacagc atccaataaa     1260

aatcgtggaa tcataaagac attttctaac gggtgcgata tgtatcaaat aaaggggtgg     1320

acactgtgtc tgtaggtaac acattatatt atgtaaaaag caagaaggta aaagtctcta     1380

tgtaaaaggt gaaccaataa taaatttcta tgacccttag tattcccctc tgatgaattt     1440

gatgcatcaa tatctcaagt caacgagaag attaacagag cctagcattt attcgtaaat     1500

ccgatgaatt attacataat gtaaatgctg gtaatccacc ataaatatca tgataactac     1560

tataattata gtgattatag taatattgtt atcttaattg ctgttggact gctcttatac     1620

tgtaaggcca gaagcacacc agtcacacta agaaagatca actgagtggt ataaataata     1680

ttgcatttag taactaa                                                    1697


<210>  2
<211>  574
<212>  PRT
<213>  respiratory syncytial virus

<400>  2

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Ala Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Ile Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  3
<211>  897
<212>  DNA
<213>  PRT

<400>  3
atgtccaaaa acaaggacca acgcaccgct aagacactag aaaagacctg ggacactctc       60

aatcatttat tattcatatc atcgggctta tataagttaa atcttaaatc tatagcacaa      120

atcacattat ccattctggc aatgataatc tcaacttcac ttataattac agccatcata      180

ttcatagcct cggcaaacca caaagtcaca ctaacaactg caatcataca agatgcaaca      240

agccagatca agaacacaac cccaacatac ctcactcagg atcctcagct tggaatcagc      300

ttctccaatc tgtctgaaat tacatcacaa accaccacca tactagcttc aacaacacca      360

ggagtcaagt caaacctgca acccacaaca gtcaagacta aaaacacaac aacaacccaa      420

acacaaccca gcaagcccac tacaaaacaa cgccaaaaca aaccaccaaa caaacccaat      480

aatgattttc acttcgaagt gtttaacttt gtaccctgca gcatatgcag caacaatcca      540

acctgctggg ctatctgcaa aagaatacca aacaaaaaac caggaaagaa aaccaccacc      600

aagcctacaa aaaaaccaac cttcaagaca accaaaaaag atctcaaacc tcaaaccact      660

aaaccaaagg aagtacccac caccaagccc acagaagagc caaccatcaa caccaccaaa      720

acaaacatca caactacact gctcaccaac aacaccacag gaaatccaaa actcacaagt      780

caaatggaaa ccttccactc aacctcctcc gaaggcaatc taagcccttc tcaagtctcc      840

acaacatccg agcacccatc acaaccctca tctccaccca acacaacacg ccagtag         897


<210>  4
<211>  298
<212>  PRT
<213>  PRT

<400>  4

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Gly Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Thr Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Val Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Thr Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Lys Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Leu Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Thr Arg Gln 
    290                 295             


<210>  5
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker peptide

<400>  5

Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker peptide

<400>  6

Ser Gly Gly Ser Gly Gly Ser Gly Thr Asn Val Thr Leu Ser 
1               5                   10                  


<210>  7
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker peptide

<400>  7

Glu Leu Pro Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr 
1               5                   10                  15      


Asn Val Thr Leu Ser 
            20      


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker peptide

<400>  8

Gln Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr Leu Ser 
1               5                   10                  15  


<210>  9
<211>  2268
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant chimeric FG polypeptide

<400>  9
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt       60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt      120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa      180

ttaagtaata tcaaggaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa      240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca      300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac      360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt      420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta      480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc      540

ttatcaaatg gagttagtgt cttaaccagc aaagtgttag acctcaaaaa ctatatagat      600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg      660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat      720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta      780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata      840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta      900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct      960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga     1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaac atgtaaagtt     1080

caatcgaatc gagtattttg tgacacaatg aacagtttaa cattaccaag tgaagtaaat     1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca     1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact     1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat     1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat     1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca     1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac     1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa     1560

tcaaccacaa atatcctggt cacactaaca actgcaatca tacaagatgc aacaagccag     1620

atcaagaaca caaccccaac atacctcacc cagaatcccc agcttggaat cagcttctcc     1680

aatctgtctg aaactacatc acaaaccacc accatactag cttcaacaac accaagtgtc     1740

aagtcaaccc tgcaatccac aacagtcaag accaaaaaca caacaacaac caaaatacaa     1800

cccagcaagc ccaccacaaa acaacgccaa aacaaaccac caaacaaacc caataatgat     1860

tttcactttg aagtgttcaa ctttgtacct tgcagcatat gcagcaacaa tccaacctgc     1920

tgggctatct gtaaaagaat accaaacaaa aaacctggaa agaaaaccac caccaagccc     1980

acaaaaaaac caaccatcaa gacaaccaaa aaagatctca aacctcaaac cacaaaacca     2040

aaggaagtac ctaccaccaa gcccacagaa aagccaacca tcaacaccac caaaacaaac     2100

atcagaacta cactgctcac caacaatacc acaggaaatc cagaacacac aagtcaaaag     2160

ggaaccctcc actcaacctc ctccgatggc aatccaagcc cttcacaagt ctatacaaca     2220

tccgagtacc tatcacaacc tccatctcca tccaacacaa caaaccag                  2268


<210>  10
<211>  1828
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide encoding a recombinant chimeric FG polypeptide

<400>  10
aagcttgcca ccatggagct gctgatcctg aaaaccaacg ccatcaccgc catcctggcc       60

gccgtgaccc tgtgcttcgc ctcctcccag aacatcaccg aagagtttta ccagtccacc      120

tgctccgccg tgtccaaggg ctacctgtcc gccctgcgga ccggctggta cacctccgtg      180

atcaccatcg agctgtccaa catcaaagaa aacaagtgca acggcaccga cgccaaggtc      240

aagctgatca agcaggaact ggacaagtac aagagcgccg tgacagaact ccagctcctg      300

atgcagtcca cccctgccac caacaacaag aagtccggcg gcagcggcgg ctctggcggc      360

tccggcggat ctggcaagaa gttcctgggc ttcctgctgg gcgctggctc cgccatcgcc      420

tccggcaccg ccgtgagcaa ggtgctgcac ctggagggcg aggtgaacaa gatcaagagc      480

gccctgctgt ccaccaacaa ggccgtggtg tccctgtcca acggcgtgtc cgtgctgacc      540

tccaaggtgc tggatctgaa gaactacatc gacaagcagc tgctgcctat cgtgaacaag      600

cagtcctgct ccatctccaa catcgagacc gtgatcgagt tccagcagaa gaacaaccgg      660

ctgctggaga tcacccgcga gttctccgtg aacgccggcg tgaccacccc tgtgtccacc      720

tacatgctga ccaactccga gctgctgtcc ctgatcaacg acatgcctat caccaacgac      780

caaaaaaagc tgatgtccaa caacgtgcag atcgtgcggc agcagtccta cagcatcatg      840

agcatcatca aggaagaagt cctggcctac gtcgtgcagc tgcctctgta cggcgtgatc      900

gacacccctt gctggaagct gcacacctcc cccctgtgca ccaccaacac caaggaaggc      960

tccaacatct gcctgacccg gaccgaccgg ggctggtact gcgacaacgc cggctccgtg     1020

tccttcttcc ctctggccga gacctgcaag gtgcagtcca accgggtgtt ctgcgacacc     1080

atgaactccc tgaccctgcc ttccgaggtg aacctgtgca acatcgacat cttcaacccc     1140

aagtacgact gcaagatcat gaccagcaag accgacgtgt cctccagcgt gatcacctcc     1200

ctgggcgcca tcgtgtcctg ctacggcaag accaagtgca ccgcctccaa caagaaccgg     1260

ggaatcatca agaccttctc caacggctgc gactacgtgt ccaataaggg cgtggacacc     1320

gtgtccgtgg gcaacacact gtactacgtg aataagcagg aaggcaagag cctgtacgtg     1380

aagggcgagc ctatcatcaa cttctacgac cctctggtgt tcccttccga cgagttcgac     1440

gcctccatca gccaggtcaa cgagaagatc aaccagtccc tggccttcat ccggaagtcc     1500

gacgagctgc tgcacaacgt gaacgctggc aagtctacca ccaacatcat ggtgaccaag     1560

cagcggcaga acaagcctcc taacaagccc aacaacgact tccacttcga ggtgttcaac     1620

ttcgtgcctt gctccatctg ctccaacaac cctacctgct gggccatctg caagagaatc     1680

cccaacaaga agccaggcaa gaaaaccacc accaagccta ccaagaagcc taccttcaag     1740

accaccaaga aggaccacaa gcctcagacc acaaagccta aggaagtgcc aaccaccaag     1800

caccaccacc atcaccactg ataatcta                                        1828


<210>  11
<211>  602
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant chimeric FG polypeptide

<400>  11

Met Glu Leu Leu Ile Leu Lys Thr Asn Ala Ile Thr Ala Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Ser Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Lys Lys Ser Gly Gly Ser Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Lys Lys Phe Leu Gly Phe Leu 
        115                 120                 125             


Leu Gly Ala Gly Ser Ala Ile Ala Ser Gly Thr Ala Val Ser Lys Val 
    130                 135                 140                 


Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser 
145                 150                 155                 160 


Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr 
                165                 170                 175     


Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro 
            180                 185                 190         


Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile 
        195                 200                 205             


Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe 
    210                 215                 220                 


Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr 
225                 230                 235                 240 


Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
                245                 250                 255     


Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser 
            260                 265                 270         


Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val 
        275                 280                 285             


Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His 
    290                 295                 300                 


Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys 
305                 310                 315                 320 


Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val 
                325                 330                 335     


Ser Phe Phe Pro Leu Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val 
            340                 345                 350         


Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu 
        355                 360                 365             


Cys Asn Ile Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr 
    370                 375                 380                 


Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile 
385                 390                 395                 400 


Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg 
                405                 410                 415     


Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys 
            420                 425                 430         


Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys 
        435                 440                 445             


Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe 
    450                 455                 460                 


Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 
465                 470                 475                 480 


Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 
                485                 490                 495     


Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile 
            500                 505                 510         


Met Val Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn 
        515                 520                 525             


Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser 
    530                 535                 540                 


Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys 
545                 550                 555                 560 


Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe Lys 
                565                 570                 575     


Thr Thr Lys Lys Asp His Lys Pro Gln Thr Thr Lys Pro Lys Glu Val 
            580                 585                 590         


Pro Thr Thr Lys His His His His His His 
        595                 600         


<210>  12
<211>  1849
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide encoding a recombinant chimeric FG polypeptide

<400>  12
aagcttgcca ccatggagct gctgatcctc aagaccaacg ccatcaccgc catcctggcc       60

gccgtgaccc tgtgcttcgc ctcctcccag aacatcaccg aagagttcta ccagtccacc      120

tgctccgccg tgtccaaggg ctacctgtcc gccctgcgga ccggctggta cacctccgtg      180

atcaccatcg agctgtccaa catcaaagaa aacaagtgca acggcaccga cgccaaggtc      240

aagctgatca agcaggaact ggacaagtac aagagcgccg tgaccgaact ccagctgctg      300

atgcagtcca cccctgccac caacaacaag aaagaactgc ctcggttcat gaactacacc      360

ctgaacaaca ccaagaacac caacgtgacc ctgagcaaga agttcctggg cttcctgctg      420

ggcgctggct ccgccatcgc ctccggcacc gccgtgagca aggtgctgca cctggagggc      480

gaggtgaaca agatcaagag cgccctgctg tccaccaaca aggccgtggt gtccctgtcc      540

aacggcgtgt ccgtgctgac ctccaaggtg ctggatctga agaactacat cgacaagcag      600

ctgctgccta tcgtgaacaa gcagtcctgc tccatctcca acatcgagac cgtgatcgag      660

ttccagcaga agaacaaccg gctgctggag atcacccgcg agttctccgt gaacgccggc      720

gtgaccaccc ctgtgtccac ctacatgctg acaaactccg agctgctctc cctgatcaac      780

gacatgccta tcaccaacga ccaaaaaaag ctgatgtcca acaacgtgca gatcgtgcgg      840

cagcagtcct acagcatcat gagcatcatc aaggaagagg tcctggccta cgtggtgcag      900

ctgcctctgt acggcgtgat cgacacccct tgctggaagc tgcacacctc ccccctgtgc      960

accaccaaca ccaaggaagg ctccaacatc tgcctgaccc ggaccgaccg gggctggtac     1020

tgcgacaacg ccggctccgt gtccttcttc cctctggccg agacctgcaa ggtgcagtcc     1080

aaccgggtgt tctgcgacac catgaactcc ctgaccctgc cttccgaggt gaacctgtgc     1140

aacatcgaca tcttcaaccc caagtacgac tgcaagatca tgaccagcaa gaccgacgtg     1200

tcctccagcg tgatcacctc cctgggcgcc atcgtgtcct gctacggcaa gaccaagtgc     1260

accgcctcca acaagaaccg gggaatcatc aagaccttct ccaacggctg cgactacgtg     1320

tccaataagg gcgtggacac cgtgtccgtg ggcaacacac tgtactacgt gaataagcag     1380

gaaggcaaga gcctgtacgt gaagggcgag cctatcatca acttctacga ccctctggtg     1440

ttcccttccg acgagttcga cgcctccatc agccaggtca acgagaagat caaccagtcc     1500

ctggccttca tccggaagtc cgacgagctg ctgcacaacg tgaacgctgg caagtctacc     1560

accaacatca tggtgaccaa gcagcggcag aacaagcctc ctaacaagcc caacaacgac     1620

ttccacttcg aggtgttcaa cttcgtgcct tgctccatct gctccaacaa ccctacctgc     1680

tgggccatct gcaagagaat ccccaacaag aagcctggca agaaaaccac caccaagcct     1740

accaagaagc ctaccttcaa gaccaccaag aaggaccaca agcctcagac cacaaagcct     1800

aaggaagtgc caaccaccaa gcaccaccac catcaccact gataatcta                 1849


<210>  13
<211>  609
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant chimeric FG polypeptide

<400>  13

Met Glu Leu Leu Ile Leu Lys Thr Asn Ala Ile Thr Ala Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Ser Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Lys Lys Glu Leu Pro Arg Phe 
            100                 105                 110         


Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr Leu Ser 
        115                 120                 125             


Lys Lys Phe Leu Gly Phe Leu Leu Gly Ala Gly Ser Ala Ile Ala Ser 
    130                 135                 140                 


Gly Thr Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
145                 150                 155                 160 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
                165                 170                 175     


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
            180                 185                 190         


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
        195                 200                 205             


Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
    210                 215                 220                 


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
225                 230                 235                 240 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
                245                 250                 255     


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
            260                 265                 270         


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
        275                 280                 285             


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
    290                 295                 300                 


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
305                 310                 315                 320 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
                325                 330                 335     


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Leu Ala Glu Thr Cys 
            340                 345                 350         


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
        355                 360                 365             


Leu Pro Ser Glu Val Asn Leu Cys Asn Ile Asp Ile Phe Asn Pro Lys 
    370                 375                 380                 


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
385                 390                 395                 400 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
                405                 410                 415     


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
            420                 425                 430         


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
        435                 440                 445             


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
    450                 455                 460                 


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
465                 470                 475                 480 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
                485                 490                 495     


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala 
            500                 505                 510         


Gly Lys Ser Thr Thr Asn Ile Met Val Thr Lys Gln Arg Gln Asn Lys 
        515                 520                 525             


Pro Pro Asn Lys Pro Asn Asn Asp Phe His Phe Glu Val Phe Asn Phe 
    530                 535                 540                 


Val Pro Cys Ser Ile Cys Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys 
545                 550                 555                 560 


Lys Arg Ile Pro Asn Lys Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro 
                565                 570                 575     


Thr Lys Lys Pro Thr Phe Lys Thr Thr Lys Lys Asp His Lys Pro Gln 
            580                 585                 590         


Thr Thr Lys Pro Lys Glu Val Pro Thr Thr Lys His His His His His 
        595                 600                 605             


His 
    

