                               SEQUENCE LISTING

<110> UCHICAGO ARGONNE, LLC
 
<120> METHODS FOR SYSTEMATIC CONTROL OF ANTIBODY STABILITY

<130> 21416-109158

<140>
<141>

<150> 61/150,562
<151> 2009-02-06

<150> 61/080,563
<151> 2008-07-14

<160> 64    

<170> PatentIn version 3.5

<210> 1
<211> 186
<212> PRT
<213> Homo sapiens

<400> 1
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys 
            180                 185     


<210> 2
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 2
Ala Ile Arg Lys Tyr Tyr Ile Gly Thr Val Glu Thr Pro Trp Asn Tyr 
1               5                   10                  15      


Thr Ser Gly Glu Ala Ser Ala Gln His Met Gly Thr Ser Gly Ser Ser 
            20                  25                  30          


Thr Met Ser Arg Thr Leu Pro Leu Ser Asn His Ile Met His Arg Lys 
        35                  40                  45              


Ala Val Phe Val Glu Tyr Lys Asp Asp Phe Phe Ser Val Pro Arg Pro 
    50                  55                  60                  


Lys Pro Leu Trp Met Gly Leu Leu Gly Pro Thr Ile Arg Thr Glu Val 
65                  70                  75                  80  


His Asp Thr Val Val Val Val Phe Lys Asn Leu Ala Ser Arg Ala Tyr 
                85                  90                  95      


Asn Leu His Ala Val Gly Met Ser Phe Trp Lys Ser Ser Glu Gly Asp 
            100                 105                 110         


Ala Tyr Glu Asp Glu Ser Thr Lys Ser Glu Gln Asp Gly Asp Asn Val 
        115                 120                 125             


Ile Pro Gly Glu Thr Tyr Thr Tyr Ala Trp His Ile Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Thr Asp Gly Asp Ser Pro Cys Leu Thr His Ala Tyr Phe Ser 
145                 150                 155                 160 


Asn Val Asn Pro Val Arg Asp Thr Asn Ser Gly Leu Val Gly Ala Leu 
                165                 170                 175     


Leu Ile Cys Lys Pro Gly Arg Leu Ser Arg 
            180                 185     


<210> 3
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 3
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ala Trp Asp Tyr 
1               5                   10                  15      


Ile His Ser Gly Leu Arg Val Ala Arg Ala Asp Ser Arg Phe Leu Ala 
            20                  25                  30          


Gly Ala Pro Gly Ala Phe Pro Phe Thr Pro Ser Val Thr Tyr Thr Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Met Val Gln Ser Phe His Thr Ala Lys Pro 
    50                  55                  60                  


Arg Pro Ala Trp Met Gly Leu Leu Gly Pro Thr Ile Trp Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Gly Tyr Asp Asp His Thr Ser Pro Thr Glu Lys Glu Asp Asp Arg Val 
        115                 120                 125             


Leu Pro Gly Lys Ser Gln Thr Tyr Ile Trp Ile Val Leu Gln Glu Gln 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser Tyr Met Ser 
145                 150                 155                 160 


His Val Asp Ser Val Asn Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Thr Leu Thr Lys 
            180                 185     


<210> 4
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 4
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Arg Gln Ser Asp Leu Leu Gln Leu Pro Thr Asp Val Arg Phe Pro Pro 
            20                  25                  30          


Arg Thr Pro Thr Pro Phe Pro Phe Gly Ala Ser Val Leu Tyr Ser Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Leu Val Arg Leu Phe Thr Gln Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Lys Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Asp Pro Gly Gly Ser His Thr Tyr Val Trp Glu Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Ser Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Val Lys 
            180                 185     


<210> 5
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 5
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Val Gln Ser Asp Leu Gly Glu Leu Pro Ser Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Ala Ser Phe Pro Phe Asn Thr Ser Val Arg Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Val Ala Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Met Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys 
            180                 185     


<210> 6
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 6
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Ala Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys 
            180                 185     


<210> 7
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 7
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Pro Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys 
            180                 185     


<210> 8
<211> 185
<212> PRT
<213> Homo sapiens

<400> 8
Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln 
            20                  25                  30          


Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val 
        35                  40                  45              


Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg 
    50                  55                  60                  


Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val 
65                  70                  75                  80  


His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg 
                85                  90                  95      


Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr 
            100                 105                 110         


Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser 
        115                 120                 125             


His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro 
    130                 135                 140                 


Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr 
145                 150                 155                 160 


Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp 
                165                 170                 175     


Asp Asn Ser Pro Ser Phe Ile Gln Ile 
            180                 185 


<210> 9
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 9
Asp Arg Ala Arg Ile Pro Tyr Thr Leu Val Met Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Arg Thr Trp Tyr Thr Ala Arg Pro Glu Pro Tyr Ile Arg 
            20                  25                  30          


Ala Met Ala Ser Gly Ala Thr Gln Asp Arg His Glu Leu His Thr Ile 
        35                  40                  45              


Asn Gly Tyr Thr Asn Gly Thr Leu Pro Gly Leu Thr Val Cys Arg Lys 
    50                  55                  60                  


Arg Gln Ile His Trp His Val Met Ala Val Gly Thr Ser Pro Asp Ile 
65                  70                  75                  80  


His Ser Ile Leu Leu Glu Ser His Thr Phe Phe Val Arg His His Arg 
                85                  90                  95      


Leu Thr Ser Leu Glu Ile Pro Pro Leu Ser Leu Leu Thr Ala Glu Thr 
            100                 105                 110         


Val Pro Ile Thr Thr Gly Arg Phe Arg Asn Phe Cys Gln Met Pro Ser 
        115                 120                 125             


His Lys Gln Gly Gly Met Glu Ala His Ile Glu Val Glu Lys Cys Ala 
    130                 135                 140                 


Asp Ala Ser Gln Trp Gln Lys His Ala His Ser Asp Glu Lys Tyr Tyr 
145                 150                 155                 160 


Glu Asn Gly Phe Ala Asp Ser Asp Met Asp Met Phe Thr Leu Asp Gly 
                165                 170                 175     


Asp Ser Pro Ala Phe Tyr Val Gln Val 
            180                 185 


<210> 10
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 10
Glu Thr Thr Gln Met Leu Gln Glu Phe Ile Leu Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Glu Ser Trp His Gly Glu Ala Asn Asp Ser Trp Thr His 
            20                  25                  30          


Ser Gly Thr Pro Ala Pro Lys Glu Pro Gln Pro Arg Val His Thr Val 
        35                  40                  45              


Asn Gly Tyr Ile Asn Ser Ser Leu Pro Gly Leu Val Leu Cys His Gly 
    50                  55                  60                  


Thr Leu Val Tyr Trp His Val Ile Gly Ser Gly Thr Gly Pro Glu Val 
65                  70                  75                  80  


His Ser Ile Phe Leu Glu Gly His Thr Phe Ser Val Arg Ser His Arg 
                85                  90                  95      


Gln Ser Ser Leu Glu Ile Ser Pro Met Thr Tyr Leu Thr Ala Gln Thr 
            100                 105                 110         


Phe Leu Gly Asp Ala Gly His Phe Leu Val Phe Cys His Ile Ser Ser 
        115                 120                 125             


His His His Ala Gly Met Glu Ala Ser Val Arg Val Asp Asn Cys Pro 
    130                 135                 140                 


Glu Glu Ile Gln Gly Lys Arg Gly Arg Ser Glu Glu Met Pro Glu Tyr 
145                 150                 155                 160 


Asp Glu Asn Leu Tyr Asp Ser Glu Met Asp Val Arg Ser Trp Asp Tyr 
                165                 170                 175     


Asp Asp Val Ser Ser Phe Ile Gln Ile 
            180                 185 


<210> 11
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 11
Glu Gly Thr Gln Asn Leu Pro Gln Phe Ile Leu Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Lys Ser Trp His Ala Glu Thr Lys Ala Ser Lys Ala Gln 
            20                  25                  30          


Thr Arg Asp Tyr Ala Ser Ala Lys Ala Ser Pro Thr Met His Thr Val 
        35                  40                  45              


Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg 
    50                  55                  60                  


Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val 
65                  70                  75                  80  


His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Gly His Arg 
                85                  90                  95      


Gln Ala Ser Leu Glu Ile Ser Pro Ala Thr Phe Leu Thr Ala Gln Thr 
            100                 105                 110         


Trp Leu Met Asp Leu Gly Ser Phe Leu Leu Phe Cys His Ile Ser Ser 
        115                 120                 125             


His Arg His Asp Gly Met Glu Ala Val Val Gln Val Asp Ala Cys Pro 
    130                 135                 140                 


Glu Glu Pro Gln Val Arg Met Lys Gln Asp Glu Glu Thr Glu Asp Tyr 
145                 150                 155                 160 


Asp Asp Asp Leu Leu Asp Ser Glu Met Asp Val Val Arg Phe Asp Pro 
                165                 170                 175     


Asp Ala Ala Pro Ser Phe Ile Gln Ile 
            180                 185 


<210> 12
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 12
Glu Lys Thr Gln His Leu His His Phe Ile Leu Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Gly Ser Pro Met Gln 
            20                  25                  30          


Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val 
        35                  40                  45              


Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg 
    50                  55                  60                  


Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val 
65                  70                  75                  80  


His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg 
                85                  90                  95      


Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr 
            100                 105                 110         


Met Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser 
        115                 120                 125             


His Gln His Asp Gly Met Glu Ala Tyr Val His Val Asp Glu Cys Pro 
    130                 135                 140                 


Glu Glu Pro Gln Gln Arg Met Lys Asn Pro Glu Glu Ala Glu Asp Tyr 
145                 150                 155                 160 


Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp 
                165                 170                 175     


Asp Asn Ser Pro Ser Phe Ile Gln Ile 
            180                 185 


<210> 13
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 13
Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Pro Ser Leu Met Gln 
            20                  25                  30          


Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val 
        35                  40                  45              


Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg 
    50                  55                  60                  


Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val 
65                  70                  75                  80  


His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg 
                85                  90                  95      


Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr 
            100                 105                 110         


Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser 
        115                 120                 125             


His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro 
    130                 135                 140                 


Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr 
145                 150                 155                 160 


Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp 
                165                 170                 175     


Asp Asn Ser Pro Ser Phe Ile Gln Ile 
            180                 185 


<210> 14
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 14
Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe 
1               5                   10                  15      


Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln 
            20                  25                  30          


Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val 
        35                  40                  45              


Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg 
    50                  55                  60                  


Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val 
65                  70                  75                  80  


His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg 
                85                  90                  95      


Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr 
            100                 105                 110         


Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser 
        115                 120                 125             


His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro 
    130                 135                 140                 


Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr 
145                 150                 155                 160 


Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp 
                165                 170                 175     


Asp Asn Ser Pro Ser Phe Ile Gln Ile 
            180                 185 


<210> 15
<211> 185
<212> PRT
<213> Homo sapiens

<400> 15
Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
1               5                   10                  15      


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
            20                  25                  30          


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
        35                  40                  45              


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
    50                  55                  60                  


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
65                  70                  75                  80  


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
                85                  90                  95      


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
            100                 105                 110         


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
        115                 120                 125             


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
    130                 135                 140                 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
145                 150                 155                 160 


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
                165                 170                 175     


Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
            180                 185 


<210> 16
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 16
Arg Ser Ala Ala Lys Lys Tyr Pro Val Ala Trp Ile His Tyr Ile Ser 
1               5                   10                  15      


Val Gln Glu Asp Asp Trp Glu Tyr Ala Pro Ser Glu Ala Thr Ser Ser 
            20                  25                  30          


Asn Gly Gly His Gln Asn Leu Tyr Leu Ser Ser His Leu His Gln Leu 
        35                  40                  45              


Gly Lys Lys Tyr Lys Lys Ala Met Tyr Ile Glu Tyr Glu Asp Glu Thr 
    50                  55                  60                  


Phe Thr Lys Arg Lys Pro Met Pro Tyr Gly Ala Gly Leu Leu Gly Pro 
65                  70                  75                  80  


Val Leu Lys Gly Glu Val Gly Asp Ser Phe Lys Ile Val Phe Arg Lys 
                85                  90                  95      


Lys Ala Ser Arg Ala Tyr Asn Ile His Pro His Gly Leu Asn Tyr Val 
            100                 105                 110         


Ser Ala Val His Thr Gln Lys Pro Ser Arg Gly Met Lys Asp Val Lys 
        115                 120                 125             


His Met Pro Ile His Pro Gly Gln Thr Phe Thr Tyr Arg Trp Lys Leu 
    130                 135                 140                 


Ala Ala Glu Glu Gly Pro Ala Arg Ala Asp Ala Pro Cys Val Thr Arg 
145                 150                 155                 160 


Phe Tyr Ala Ser Ser Ile Asp Leu Asp Lys Asp Thr Ala Ser Gly Leu 
                165                 170                 175     


Ile Gly Pro Leu Leu Ile Cys Cys Lys 
            180                 185 


<210> 17
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 17
Arg Ser Phe Ala Lys Lys Asp Pro Lys Met Trp Pro His Tyr Ile Ala 
1               5                   10                  15      


Ala Glu Glu Gly Asp Trp Asp Tyr Ala Pro Ala Ala Pro Ser Leu Asn 
            20                  25                  30          


Ala Thr Asn Leu Arg Arg Arg Tyr Leu Lys Arg Gly Pro Gln Gly Gly 
        35                  40                  45              


Gly Ser Lys Tyr Lys Lys Val Arg Phe Val Ala Tyr Thr Asp Glu Thr 
    50                  55                  60                  


Phe His Thr Arg Glu Val Thr Ser Arg Glu Gln Gly Ile Leu Gly Pro 
65                  70                  75                  80  


Leu Leu Tyr Gly Glu Val Gly Asp Gln Leu Leu Ile Ile Phe Lys Asn 
                85                  90                  95      


Arg Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Arg Ser Val 
            100                 105                 110         


Thr Pro Tyr Tyr Ala Gly Arg Leu Leu Gln Gly Ile Lys His Ile Lys 
        115                 120                 125             


Asp Leu Pro Ile Arg Pro Gly Glu Ser Phe Lys Tyr Lys Trp Asp Ile 
    130                 135                 140                 


Thr Leu Glu Asp Gly Pro Thr Gln Ser Asp Pro Arg Cys Leu Thr Arg 
145                 150                 155                 160 


Tyr Tyr Tyr Ser Ala Val Asn Pro Gln Gln Asp Leu Ala Ser Gly Leu 
                165                 170                 175     


Ile Gly Pro Leu Leu Ile Cys Arg Lys 
            180                 185 


<210> 18
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 18
Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Thr His Tyr Ile Ala 
1               5                   10                  15      


Ala Glu Glu Val Asp Trp Asp Tyr Ala Pro Val Lys Leu Pro Ser Glu 
            20                  25                  30          


Asp Arg Ser Ser Ser Ser Gln Tyr Leu Gly Gly Gly Pro Gln Arg Ile 
        35                  40                  45              


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
    50                  55                  60                  


Phe Lys Thr Arg Glu Thr Gln Gln Ser Glu Ser Gly Ile Leu Gly Pro 
65                  70                  75                  80  


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
                85                  90                  95      


Leu Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
            100                 105                 110         


Gly Pro Leu Tyr Pro Met Arg Leu Pro Lys Gly Trp Lys His Leu Lys 
        115                 120                 125             


Asp Val Pro Ile Ala Pro Gly Glu Ile Phe Lys Tyr Lys Trp Ser Val 
    130                 135                 140                 


Thr Thr Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
145                 150                 155                 160 


Tyr Tyr Ser Ser Phe Val Asn Ala Val Arg Asp Leu Ala Ser Gly Leu 
                165                 170                 175     


Ile Gly Pro Leu Leu Ile Cys Phe Lys 
            180                 185 


<210> 19
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 19
Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
1               5                   10                  15      


Ala Glu Glu Met Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Leu 
            20                  25                  30          


Asp Arg Ser Thr Lys Ser Gln Tyr Leu Glu Ala Gly Pro Gln Arg Ile 
        35                  40                  45              


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
    50                  55                  60                  


Phe Lys Thr Arg Glu Lys Ser Gln Pro Glu Ser Gly Ile Leu Gly Pro 
65                  70                  75                  80  


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
                85                  90                  95      


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
            100                 105                 110         


Asn Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Lys Lys His Leu Lys 
        115                 120                 125             


Asp Ile Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
    130                 135                 140                 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
145                 150                 155                 160 


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
                165                 170                 175     


Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
            180                 185 


<210> 20
<211> 185
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 20
Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
1               5                   10                  15      


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
            20                  25                  30          


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
        35                  40                  45              


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
    50                  55                  60                  


Phe Lys Thr Arg Glu Ser Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
65                  70                  75                  80  


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
                85                  90                  95      


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
            100                 105                 110         


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
        115                 120                 125             


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
    130                 135                 140                 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
145                 150                 155                 160 


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
                165                 170                 175     


Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
            180                 185 


<210> 21
<211> 183
<212> PRT
<213> Homo sapiens

<400> 21
Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn 
1               5                   10                  15      


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
            20                  25                  30          


Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu 
        35                  40                  45              


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
    50                  55                  60                  


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
65                  70                  75                  80  


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
                85                  90                  95      


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
            100                 105                 110         


Thr Leu Phe Pro Phe Ser Gly Glu Ile Phe Met Ser Met Glu Asn Pro 
        115                 120                 125             


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
    130                 135                 140                 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
145                 150                 155                 160 


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
                165                 170                 175     


Asn Asn Ala Ile Glu Pro Arg 
            180             


<210> 22
<211> 183
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 22
Lys Thr Met Asp Gln Arg Gly Asn Gln Met Met Ser Asp Glu Met Arg 
1               5                   10                  15      


Leu Leu Leu Phe Ser Ile Leu Asp Glu Asn Gln Ser Trp Tyr Ile Ala 
            20                  25                  30          


Glu Asp Met Arg Arg Leu Ser Leu Ser Ala Thr Val Leu His Pro Gln 
        35                  40                  45              


Asp Ser Gly Phe Glu Leu Ser Asn Leu Met Tyr Thr Ile Asn Gly Phe 
    50                  55                  60                  


Val Phe Asn His Leu Glu Leu Thr Ala Cys Leu His Glu Val Thr Ala 
65                  70                  75                  80  


Trp His Val Leu Ser Val Gly Ala Gln Ser Asp Phe Leu Ser Ile Phe 
                85                  90                  95      


Phe Ser Gly His Thr Phe Glu His Arg Leu Val Phe Ala Asp Val Leu 
            100                 105                 110         


Thr Val Phe Pro His Ser Gly Val Ile Tyr Met Thr Tyr Asp Lys Leu 
        115                 120                 125             


Gly Val Trp Val Ile Gly Cys Arg Asn Pro Glu Leu Arg Lys Ser Gly 
    130                 135                 140                 


Met Ser Ala Lys Phe Thr Val Tyr Thr Cys Asn Arg Asp Ile Asp Asp 
145                 150                 155                 160 


Tyr Ser Asp Asn Thr Tyr Asp Gly Met Pro Thr His Pro Val Asn Glu 
                165                 170                 175     


Lys His Gly Val Lys Pro Arg 
            180             


<210> 23
<211> 183
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 23
Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Asp Arg Asn 
1               5                   10                  15      


Val Val Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Ser 
            20                  25                  30          


Glu Asn Ile Gln Arg Phe Cys Thr Glu Glu Asp Lys Thr Asp Lys His 
        35                  40                  45              


Asp Pro Glu Phe Tyr Thr Ser Asn Val Met His Ser Ile Asn Gly Tyr 
    50                  55                  60                  


Val Phe Asp Gly Leu Gln Leu Arg Leu Cys Leu His Glu Val Val Tyr 
65                  70                  75                  80  


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
                85                  90                  95      


Phe Ser Gly Tyr Thr Phe Arg His Lys Ala Val Ser Glu Asp Thr Leu 
            100                 105                 110         


Thr Leu Phe Pro Phe Ser Gly Glu Ile Phe Met Ser Met Glu Asn Pro 
        115                 120                 125             


Gly Thr Trp Ala Leu Gly Cys His Asn Ser Asp Phe Arg Glu Arg Gly 
    130                 135                 140                 


Met His Ala Leu Leu Lys Val Ala Gln Cys Pro Glu Ser Val Ser Asp 
145                 150                 155                 160 


Tyr Tyr Gly Glu Ile Tyr Glu Glu Val Ile Ile Ser Leu Leu Ala Gly 
                165                 170                 175     


Asp Ser Ile Leu Gln Pro Arg 
            180             


<210> 24
<211> 183
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 24
Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn 
1               5                   10                  15      


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Pro 
            20                  25                  30          


Glu Asn Ile Gln Arg Phe Leu Pro Asp Pro Ala His Val Gln Leu Glu 
        35                  40                  45              


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
    50                  55                  60                  


Val Phe Asp Ala Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
65                  70                  75                  80  


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
                85                  90                  95      


Phe Ser Gly Tyr Thr Phe Lys His Lys Asn Val Tyr Glu Asp Thr Leu 
            100                 105                 110         


Thr Leu Phe Pro Phe Ser Gly Glu Ile Phe Met Ser Met Glu Asn Pro 
        115                 120                 125             


Gly Leu Trp Asn Leu Gly Cys His Asn Ser Asp Phe Arg Asp Arg Gly 
    130                 135                 140                 


Met Thr Ala Leu Leu Lys Val Thr Ser Cys Asp Leu Gly Thr Gly Asp 
145                 150                 155                 160 


Tyr Tyr Leu Asp Tyr Tyr Glu Asp Pro Leu Gly Phe Leu Leu Arg Asn 
                165                 170                 175     


Asn Asn Tyr Ile Glu Pro Arg 
            180             


<210> 25
<211> 183
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 25
Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn 
1               5                   10                  15      


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Glu 
            20                  25                  30          


Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Glu Val Gln Leu Glu 
        35                  40                  45              


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
    50                  55                  60                  


Val Phe Asp Gln Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
65                  70                  75                  80  


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
                85                  90                  95      


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
            100                 105                 110         


Thr Leu Phe Pro Phe Ser Gly Glu Ile Phe Met Ser Met Glu Asn Pro 
        115                 120                 125             


Gly Leu Trp Thr Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
    130                 135                 140                 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
145                 150                 155                 160 


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Pro Leu Leu Ser Lys 
                165                 170                 175     


Asn Asn Phe Ile Glu Pro Arg 
            180             


<210> 26
<211> 183
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 26
Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn 
1               5                   10                  15      


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
            20                  25                  30          


Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu 
        35                  40                  45              


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
    50                  55                  60                  


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
65                  70                  75                  80  


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
                85                  90                  95      


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
            100                 105                 110         


Thr Leu Phe Pro Phe Ser Gly Glu Ile Phe Met Ser Met Glu Asn Pro 
        115                 120                 125             


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
    130                 135                 140                 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
145                 150                 155                 160 


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Gln Leu Leu Ser Lys 
                165                 170                 175     


Asn Asn Ala Ile Glu Pro Arg 
            180             


<210> 27
<211> 183
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 27
Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn 
1               5                   10                  15      


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
            20                  25                  30          


Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu 
        35                  40                  45              


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
    50                  55                  60                  


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
65                  70                  75                  80  


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
                85                  90                  95      


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
            100                 105                 110         


Thr Leu Phe Pro Phe Ser Gly Glu Ile Phe Met Ser Met Glu Asn Pro 
        115                 120                 125             


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
    130                 135                 140                 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
145                 150                 155                 160 


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Asp Leu Leu Ser Lys 
                165                 170                 175     


Asn Asn Ala Ile Glu Pro Arg 
            180             


<210> 28
<211> 187
<212> PRT
<213> Homo sapiens

<400> 28
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
1               5                   10                  15      


Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
            20                  25                  30          


Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
        35                  40                  45              


Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
    50                  55                  60                  


Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
65                  70                  75                  80  


Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
                85                  90                  95      


Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
            100                 105                 110         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        115                 120                 125             


Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
    130                 135                 140                 


Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
145                 150                 155                 160 


Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
                165                 170                 175     


Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 29
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 29
Arg Gln Ile Pro Leu Ser Val Val Lys Pro Glu Glu Asp Lys Thr Glu 
1               5                   10                  15      


Tyr Asp Asp Ile Phe Thr Thr Asp Thr Thr Arg Gln Asp Phe Asp Ile 
            20                  25                  30          


Tyr Gly Asp Glu Ile Ile Gln Asp Leu Arg Asn Phe Gln Gln Arg Ile 
        35                  40                  45              


Arg Gln Tyr Phe Ile Ala Ala Met Glu Gln Ile Trp Glu Tyr Gly Leu 
    50                  55                  60                  


Gly Arg Pro Leu Tyr Ala Leu Gly Asp Ser Val Trp Asn Asp Asp Ala 
65                  70                  75                  80  


Gln Arg Tyr Arg Lys Val Ile Phe Arg Glu Tyr Ala Asp Gly Ser Phe 
                85                  90                  95      


Ser Gln Arg Ser His Arg Gly Glu Leu Asp Lys His Leu Gly Ile Leu 
            100                 105                 110         


Gly Pro Cys Ile Arg Ala Glu Ile Glu Asp Thr Ile Val Val Lys Phe 
        115                 120                 125             


Lys Asn Glu Ala Ser Arg Pro Phe Ser Phe His Ser Ser Leu Val Gly 
    130                 135                 140                 


Tyr Lys Asp Ala Glu Ser Gly Gly Glu Gly Pro Arg Gln Lys Phe Val 
145                 150                 155                 160 


Asn Pro Gln Glu Val Glu Val Tyr Ser Trp Arg Glu Arg Pro Gln Met 
                165                 170                 175     


Ala Pro Thr Glu Arg Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 30
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 30
Arg Lys Ile Ser Val Thr Ala Pro Gln Arg Gln Ser Asn Ala Phe Tyr 
1               5                   10                  15      


Tyr Asp Asp Ala Val Ser Ile Glu Ile Lys Gly Glu Asp Phe Asp Ile 
            20                  25                  30          


Tyr Ser Glu Tyr Ala Lys Gln Gly Pro Arg Ser Phe Gln Gly Gln Thr 
        35                  40                  45              


Arg His Tyr Phe Ile Ala Ala Val Glu Glu Leu Trp Asp Tyr Gly Val 
    50                  55                  60                  


Arg Lys Ser Pro Arg Ile Leu Lys Ala Thr Tyr Arg Arg Lys Asn Phe 
65                  70                  75                  80  


Ala Gln Phe Lys Lys Val Val Phe Gln Glu Phe Leu Asp Gly Ser Phe 
                85                  90                  95      


Thr Gln Pro Val Met Arg Gly Glu Leu Asn Ala His Leu Gly Leu Leu 
            100                 105                 110         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        115                 120                 125             


Arg Asn Met Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Gln Ser 
    130                 135                 140                 


Tyr Pro Glu Asp Asp Gly His Gly Gly Ala Pro Arg Arg Thr Phe Val 
145                 150                 155                 160 


Gln Pro Asn Glu Thr Arg Ile Tyr Phe Trp Lys Val Leu Ser His Met 
                165                 170                 175     


Ala Pro Thr Asp Gly Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 31
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 31
Arg Glu Ile Ile Arg Thr Thr Ile Gln Ser His Gln Glu Asn Met Asp 
1               5                   10                  15      


Tyr Asp Asp Tyr Ser Ser Ser Glu Met Lys Ile Glu Asp Phe Asp Ile 
            20                  25                  30          


Tyr Asp Glu Asn Glu Gly Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
        35                  40                  45              


Arg His Tyr Phe Ile Ala Ala Val Glu Val Leu Trp Asp Tyr Gly Asn 
    50                  55                  60                  


Gln Thr Ser Pro Gly Phe Leu Arg Asn Arg Gly Gln Ser Gly Glu Val 
65                  70                  75                  80  


Arg Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
                85                  90                  95      


Thr Gln Pro Ala Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
            100                 105                 110         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        115                 120                 125             


Arg Asn Leu Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
    130                 135                 140                 


Tyr Glu Glu Asp Gln Leu Gln Gly Ala Glu Pro Arg His Asn Phe Val 
145                 150                 155                 160 


Arg Pro Asn Glu Thr Lys Glu Tyr Phe Trp Lys Val Gln His His Met 
                165                 170                 175     


Ala Pro Thr Met Gln Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 32
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 32
Arg Glu Ile Thr Arg Thr Thr Phe Gln Ser Asp Gln Glu Glu Ile Asp 
1               5                   10                  15      


Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Pro Glu Asp Phe Asp Ile 
            20                  25                  30          


Tyr Asp Glu Asp Glu His Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
        35                  40                  45              


Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
    50                  55                  60                  


Ser Glu Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Pro Val 
65                  70                  75                  80  


Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
                85                  90                  95      


Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
            100                 105                 110         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        115                 120                 125             


Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
    130                 135                 140                 


Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Ser Asn Phe Val 
145                 150                 155                 160 


Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
                165                 170                 175     


Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 33
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 33
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
1               5                   10                  15      


Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
            20                  25                  30          


Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
        35                  40                  45              


Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
    50                  55                  60                  


Ser Val Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
65                  70                  75                  80  


Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
                85                  90                  95      


Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
            100                 105                 110         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        115                 120                 125             


Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
    130                 135                 140                 


Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
145                 150                 155                 160 


Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
                165                 170                 175     


Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 34
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 34
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
1               5                   10                  15      


Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
            20                  25                  30          


Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
        35                  40                  45              


Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
    50                  55                  60                  


Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
65                  70                  75                  80  


Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
                85                  90                  95      


Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
            100                 105                 110         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        115                 120                 125             


Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
    130                 135                 140                 


Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
145                 150                 155                 160 


Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
                165                 170                 175     


Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala 
            180                 185         


<210> 35
<211> 186
<212> PRT
<213> Homo sapiens

<400> 35
Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala 
            20                  25                  30          


His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val 
        115                 120                 125             


Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
            180                 185     


<210> 36
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 36
Trp Ala Tyr Ser Ser Asn Val Asp Lys Asp Arg Asp Met Asn Ser Gly 
1               5                   10                  15      


Leu Val Gly Pro Leu Ile Ile Cys Arg Ala Gly Val Leu Ser Ala Ser 
            20                  25                  30          


Arg Lys Thr Pro Glu Ser Ile Arg Glu Phe Ala Leu Val Leu Ala Val 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Cys Pro Glu Asn Leu Lys Arg Lys 
    50                  55                  60                  


Cys Lys Thr Pro Arg His Val Thr Thr Asp Asn Pro Ala Leu Arg Gln 
65                  70                  75                  80  


Glu Phe Ser Phe Arg Ala Val Asn Gly Tyr Val Lys Glu Ser Leu Leu 
                85                  90                  95      


Gly Leu Leu Val Ala Glu Asn Arg Lys Val Arg Trp His Leu Leu Asn 
            100                 105                 110         


Val Cys Asn Thr Gly Asp Thr Gln Ala Val His Phe Ser Gly His Val 
        115                 120                 125             


Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
            180                 185     


<210> 37
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 37
Trp Ala Tyr Leu Ser Thr Val Asp Leu Glu Lys Asp Leu His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Val Val Cys Lys Ser Ser Thr Leu His Ser Gly 
            20                  25                  30          


Phe Ala Arg Gln Leu Ala Val Gln Glu Phe Ala Leu Leu Phe His Thr 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Met Ala Glu Asn Val Arg Arg Tyr 
    50                  55                  60                  


Cys Ala Pro Pro Cys Gly Leu Pro Lys Gly Asp Pro His Trp His Arg 
65                  70                  75                  80  


Ser His Lys Phe His Ala Ile Asn Gly Tyr Ile Gly Asp Ala Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Gly Gln Arg Thr Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Asp Pro Glu His Ala His Ser Ile His Phe His Ala Gln Met 
        115                 120                 125             


Val Ser Ile His Thr Thr Gln Glu His Arg Thr Gly Val Cys Asn Leu 
    130                 135                 140                 


Phe Pro Gly Ile Phe Gly Thr Leu Glu Met Gln Pro Pro Gln Val Gly 
145                 150                 155                 160 


Thr Trp Gln Ile Glu Ser Lys Val Gly Glu Ser Gln Gln Ala Gly Met 
                165                 170                 175     


Arg Ala Thr Leu Leu Val Tyr Asn Lys Glu 
            180                 185     


<210> 38
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 38
Trp Ala Tyr Tyr Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Arg Asn Thr Leu Asn Thr Arg 
            20                  25                  30          


Leu His Arg Gln Pro Asp Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Glu Glu Asn Met Asp Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Phe Asn Leu Gln Asp Pro Asp Tyr Lys Ile 
65                  70                  75                  80  


Asn Asn Arg Phe His Ala Ile Asn Gly Tyr Ile Ala Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Gln Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asp Glu Glu Tyr His Ser Ile His Phe Ser Gly Leu Ser 
        115                 120                 125             


Phe Thr Val Arg Asp Ser Gly Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Thr Thr Val Glu Met Ile Pro Ser Arg Ala Gly 
145                 150                 155                 160 


Ile Trp Leu Val Glu Cys Thr Ile Gly Glu His Leu Arg Ala Gly Met 
                165                 170                 175     


Ser Thr Lys Phe Leu Val Tyr Ser Thr Gln 
            180                 185     


<210> 39
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 39
Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Pro Asn Thr Leu Asn Pro Ala 
            20                  25                  30          


His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Thr Gln Arg Glu Asp Pro Trp Phe Lys Glu 
65                  70                  75                  80  


Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln His Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Pro 
        115                 120                 125             


Phe Thr Val Arg Ala Gly Lys Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Arg Pro Ser His Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu Leu Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Arg 
            180                 185     


<210> 40
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 40
Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala 
            20                  25                  30          


His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Ala Gln Met Glu Asp Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val 
        115                 120                 125             


Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Thr Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
            180                 185     


<210> 41
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 41
Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala 
            20                  25                  30          


His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val 
        115                 120                 125             


Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
            180                 185     


<210> 42
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 42
Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala 
            20                  25                  30          


His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val 
        115                 120                 125             


Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
            180                 185     


<210> 43
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 43
Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
1               5                   10                  15      


Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala 
            20                  25                  30          


His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 
        35                  40                  45              


Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 
    50                  55                  60                  


Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 
                85                  90                  95      


Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser 
            100                 105                 110         


Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val 
        115                 120                 125             


Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu 
    130                 135                 140                 


Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly 
145                 150                 155                 160 


Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met 
                165                 170                 175     


Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
            180                 185     


<210> 44
<211> 150
<212> PRT
<213> Homo sapiens

<400> 44
Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 
            20                  25                  30          


Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 
    50                  55                  60                  


Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln 
65                  70                  75                  80  


Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg 
                85                  90                  95      


Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 
            100                 105                 110         


Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Met Gly Cys Asp 
145                 150 


<210> 45
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 45
Cys Asn Ile Ala Ile Gly Met Gln Ser Arg Arg Ile Gln Asn Ser Gln 
1               5                   10                  15      


Ile Thr Ala Ser Asp His His Gly Leu Trp Thr Pro Asn Leu Ala Arg 
            20                  25                  30          


Leu Asn His Ala Gly Ser Val Asn Ala Trp Met Ala Gln Asp Ala His 
        35                  40                  45              


Pro Trp Leu Gln Val Asp Leu Leu Thr Leu Val Ile Val His Ser Ile 
    50                  55                  60                  


Met Thr Gln Gly Ala Lys His Gln Leu Ser Glu Phe Phe Val Ile Leu 
65                  70                  75                  80  


Tyr Thr Val Arg His Ser Asn Asp Gln Asn Asn Trp His Ser Tyr Gln 
                85                  90                  95      


Gly Asn Thr Thr Ser Ser Gln Tyr Met Phe Asn Ala Asn Met Asp Ala 
            100                 105                 110         


Thr Thr Val Arg Ala Asn Thr Phe Asp Pro Pro Ile Val Gly Gln Tyr 
        115                 120                 125             


Ile Cys Val Gln Pro Ser Thr Ser Gln Gly Gln Thr Ala Leu Arg Ile 
    130                 135                 140                 


Glu Leu Leu Gly Cys Asp 
145                 150 


<210> 46
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 46
Cys Gln Ala Pro Leu Gly Met Ala Ser Gly Ser Ile Ala Asp Pro Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Tyr Glu Gly Pro Trp Lys Pro Gln Leu Ala Arg 
            20                  25                  30          


Leu Glu Asn Thr Gly Ser Ile Asn Ala Trp Ser Gly Gly Ser Gly Ala 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu Glu Pro Thr Ile Leu His Gly Ile 
    50                  55                  60                  


Glu Thr Gln Gly Ala Arg Thr Arg Phe Ser Ser Leu Tyr Thr Ser Gln 
65                  70                  75                  80  


Phe Ser Ile Phe Tyr Ser Leu Asp Gly Arg Gln Trp Leu Lys Tyr Lys 
                85                  90                  95      


Gly Asn Ser Thr Lys Ala Tyr Met Thr Phe Phe Gly Asn Val Asp Gly 
            100                 105                 110         


Ser Arg Ile Lys Glu Asn Ser Phe Ser Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Ile Asn Pro Leu His Ala Ser Lys Arg Pro Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Ile Gly Cys Asp 
145                 150 


<210> 47
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 47
Cys Gln Val Pro Leu Gly Met Ala Ser Gly Tyr Ile Thr Asp Lys Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Gln Tyr Gly Asp Trp Ala Pro Glu Leu Ala Arg 
            20                  25                  30          


Leu His Ser Ser Gly Ser Ile Asn Ala Trp Ser Thr Ser Glu Pro Asn 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu His Pro Lys Ile Ile His Gly Ile 
    50                  55                  60                  


Gln Thr Gln Gly Ala Arg Gln Ser Phe Ser Ser Leu Tyr Ile Ser Gln 
65                  70                  75                  80  


Phe Ile Ile Ser Tyr Ser Leu Asp Gly Ser Thr Trp Lys Val Tyr Arg 
                85                  90                  95      


Gly Asn Ser Thr Gly Pro Leu Met Val Phe Phe Gly Asn Val Asp Ser 
            100                 105                 110         


Ser Gly Ile Lys His Asn Arg Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Leu His Pro Thr His Pro Ser Ile Arg Ser Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Met Gly Cys Asp 
145                 150 


<210> 48
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 48
Cys Gln Asn Pro Leu Gly Met Ala Ser Gly Gln Ile Arg Asp Phe Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 
            20                  25                  30          


Leu His Leu Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 
    50                  55                  60                  


Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln 
65                  70                  75                  80  


Phe Ile Ile Met Tyr Ser Leu Asp Gly Gln Arg Trp Ser Thr Tyr Arg 
                85                  90                  95      


Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 
            100                 105                 110         


Ser Gly Ile Lys His Asn Val Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Leu His Pro Thr His Phe Ser Ile Arg Ser Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Met Gly Cys Asp 
145                 150 


<210> 49
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 49
Cys Gln Gln Pro Leu Gly Met Ala Ser Gly Trp Ile Arg Asp Phe Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 
            20                  25                  30          


Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 
    50                  55                  60                  


Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln 
65                  70                  75                  80  


Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg 
                85                  90                  95      


Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 
            100                 105                 110         


Ser Gly Ile Lys His Asn Leu Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Met Gly Cys Asp 
145                 150 


<210> 50
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 50
Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 
            20                  25                  30          


Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 
    50                  55                  60                  


Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln 
65                  70                  75                  80  


Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg 
                85                  90                  95      


Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 
            100                 105                 110         


Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Met Gly Cys Asp 
145                 150 


<210> 51
<211> 150
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 51
Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln 
1               5                   10                  15      


Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 
            20                  25                  30          


Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe 
        35                  40                  45              


Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 
    50                  55                  60                  


Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln 
65                  70                  75                  80  


Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg 
                85                  90                  95      


Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 
            100                 105                 110         


Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
        115                 120                 125             


Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
    130                 135                 140                 


Glu Leu Met Gly Cys Asp 
145                 150 


<210> 52
<211> 162
<212> PRT
<213> Homo sapiens

<400> 52
Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser 
1               5                   10                  15      


Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr 
            20                  25                  30          


Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala 
        35                  40                  45              


Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser 
65                  70                  75                  80  


Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 
                85                  90                  95      


Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val 
            100                 105                 110         


Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp 
        115                 120                 125             


Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val 
    130                 135                 140                 


His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp 
145                 150                 155                 160 


Leu Tyr 
        


<210> 53
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 53
Phe Ala Ser Cys Ser Ile Pro Leu Gly Leu Gln Asn Gly Val Ile Ala 
1               5                   10                  15      


Asp Thr Arg Val Ser Ala Ser Ser His Leu Asn Ser Ile Leu Thr Ala 
            20                  25                  30          


Trp Pro Pro Ala Gln Ala Arg Leu Asn Gln Arg Gly Lys Thr Asn Ala 
        35                  40                  45              


Trp Arg Pro Arg Gly Ser Asp Ala Glu Gln Trp Leu Gln Val Asp Leu 
    50                  55                  60                  


Arg Arg Leu Val Arg Ile Thr Ala Ile Ile Thr Lys Gly Ala Arg Ala 
65                  70                  75                  80  


Ile Phe Ile Asn Met Phe Val Thr Lys Phe Ala Val Thr Thr Ser Arg 
                85                  90                  95      


Asp Gly Arg His Trp Ser Pro Ile Leu Tyr Asp Asp His Thr Lys Ile 
            100                 105                 110         


Ile Lys Ala Asn Lys Asp Ala Ser Ser Thr Met Met Ser Cys Val Glu 
        115                 120                 125             


Ser Pro Arg Val Ala Arg Phe Val Arg Leu His Pro Thr Ile His Gly 
    130                 135                 140                 


Gln His Ile Ala Leu Arg Ile Glu Ile Leu Gly Cys Asp Thr Gln Glu 
145                 150                 155                 160 


Gln Tyr 
        


<210> 54
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 54
Leu Asn Ser Cys Ser Ala Pro Leu Gly Met Glu Asp Arg Trp Ile Pro 
1               5                   10                  15      


Asp Ser Ser Phe Val Ala Ser Ser Ser Lys Ser Thr Thr Phe Ser Asn 
            20                  25                  30          


Trp Ala Pro Ser Leu Ala Arg Leu Arg Leu Glu Gly Gly Ala Asn Ala 
        35                  40                  45              


Trp Arg Pro Glu Ala Gly Ser Pro Thr Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Gly Ala Val Lys Lys Val Thr Gly Val Val Thr Gln Gly Thr Lys His 
65                  70                  75                  80  


Val Leu Ser Ala Met Met Val Arg Glu Phe Ser Leu Ser Ile Ser Gln 
                85                  90                  95      


Asp Gly Val Asn Trp Thr Gln Val Arg His Lys Ser Gly Leu Lys Val 
            100                 105                 110         


Phe Arg Gly Asn Arg Asp His Thr Glu Glu Ala Arg Leu Arg Phe His 
        115                 120                 125             


Ala Pro Leu Phe Gly Arg Tyr Ile Arg Ile His Pro Lys Val Trp Glu 
    130                 135                 140                 


Arg Asp Ile Ala Leu Arg Leu Glu Phe Leu Gly Cys Glu Ala Gln Gln 
145                 150                 155                 160 


Glu Tyr 
        


<210> 55
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 55
Leu Asn Ser Cys Ser Leu Pro Leu Gly Met Glu Ser Lys Gly Ile Ser 
1               5                   10                  15      


Asp Gln Gln Ile Thr Ala Ser Ser Tyr Ser Ala Gly Ala Phe Arg Ser 
            20                  25                  30          


Trp Thr Pro Ser Lys Ala Arg Leu His Leu Gln Gly Ser Ser Asn Ala 
        35                  40                  45              


Trp Arg Pro Lys Glu Asn Arg Pro His Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Glu Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser 
65                  70                  75                  80  


Leu Leu Thr Lys Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 
                85                  90                  95      


Asp Gly Gln Arg Trp Thr His Phe Phe Glu Gly Gly Arg Glu Lys Val 
            100                 105                 110         


Phe Gln Gly Asn Asn Asp Tyr Asp Thr Pro Val Leu Thr Ala Leu Asp 
        115                 120                 125             


Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Trp Gly Trp Ala 
    130                 135                 140                 


His Gln Ile Ala Leu Arg Val Glu Val Leu Gly Cys Glu Ala Gln Asp 
145                 150                 155                 160 


Leu Tyr 
        


<210> 56
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 56
Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Arg Ile Ser 
1               5                   10                  15      


Asp Glu Gln Ile Thr Ala Ser Ser Tyr Tyr Trp Asn Leu Phe Ala Thr 
            20                  25                  30          


Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala 
        35                  40                  45              


Trp Arg Pro Gln Thr Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser 
65                  70                  75                  80  


Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 
                85                  90                  95      


Asp Gly His Ala Trp Thr Phe Phe Phe Gln Asn Gly Lys Val Lys Val 
            100                 105                 110         


Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Pro Leu Asp 
        115                 120                 125             


Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Arg Ser Trp His 
    130                 135                 140                 


His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp 
145                 150                 155                 160 


Leu Tyr 
        


<210> 57
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 57
Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser 
1               5                   10                  15      


Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr 
            20                  25                  30          


Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala 
        35                  40                  45              


Trp Arg Pro Gln Asn Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser 
65                  70                  75                  80  


Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 
                85                  90                  95      


Asp Gly His Gln Trp Thr Arg Phe Phe Gln Asn Gly Lys Val Lys Val 
            100                 105                 110         


Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ile Leu Asp 
        115                 120                 125             


Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Leu Ser Trp Ile 
    130                 135                 140                 


His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp 
145                 150                 155                 160 


Leu Tyr 
        


<210> 58
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 58
Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser 
1               5                   10                  15      


Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr 
            20                  25                  30          


Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala 
        35                  40                  45              


Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser 
65                  70                  75                  80  


Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 
                85                  90                  95      


Asp Gly His Gln Trp Thr Ser Phe Phe Gln Asn Gly Lys Val Lys Val 
            100                 105                 110         


Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp 
        115                 120                 125             


Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val 
    130                 135                 140                 


His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp 
145                 150                 155                 160 


Leu Tyr 
        


<210> 59
<211> 162
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Factor VIII polypeptide

<400> 59
Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser 
1               5                   10                  15      


Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr 
            20                  25                  30          


Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala 
        35                  40                  45              


Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 
    50                  55                  60                  


Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser 
65                  70                  75                  80  


Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 
                85                  90                  95      


Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val 
            100                 105                 110         


Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp 
        115                 120                 125             


Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val 
    130                 135                 140                 


His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp 
145                 150                 155                 160 


Leu Tyr 
        


<210> 60
<211> 114
<212> PRT
<213> Homo sapiens

<400> 60
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Ser Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Ser Thr Pro Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210> 61
<211> 114
<212> PRT
<213> Homo sapiens

<400> 61
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Leu Leu Asp Ala 
            20                  25                  30          


Ser Phe Asp Thr Asn Thr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Ser Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210> 62
<211> 114
<212> PRT
<213> Homo sapiens

<400> 62
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Pro Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


His Tyr Tyr Ser His Pro Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Leu Lys 
        


<210> 63
<211> 114
<212> PRT
<213> Homo sapiens

<400> 63
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Lys Asn Asp Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Gly Ser Gly Thr Asn Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Thr Thr Pro Gly Thr Phe Gly Gln Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210> 64
<211> 114
<212> PRT
<213> Homo sapiens

<400> 64
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Thr Arg Asn Lys Ile Cys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Thr Pro Gln Leu Leu Ser Tyr Trp Ala Ser Ser Arg Gln Ser Gly Ser 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Gly Ser Gly Thr Asp Phe Ser Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly Thr Arg Val Glu 
            100                 105                 110         


Ile Arg 
        


