			SEQUENCE LISTING

<110> Mijts, Benjamin
      Muley, Sheela
      Liang, Jack
      Newman, Lisa M.
      Zhang, Xiyun
      Lalonde, James
      Clay, Michael D.
      Zhu, Jun
      Gruber, John M.
      Colbeck, Jeffrey
      Munger, John D., Jr.
      Mavinhalli, Jagadeesh
      Sheldon, Roger
 
<120> BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY 
      STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
 
<130> CX2-020WO1
 
<150> 61/075,243
<151> 2008-06-24
 
 
<160> 36
 
<210> 1
<211> 1485
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Aspergillus Niger monoamine oxidase (MAON)
 
<400> 1
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagcacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gtactattca gtttagccca 960
gcactgtcca cggaacgcat ctccgctatg caggcaggcc atgttaacat gtgcaccaaa 1020
gtgcatgcgg aagtcgataa taaggatatg cgttcatgga cgggtatcgc ctatccgttc 1080
aacaaattat gctacgctat cggcgatggc acgaccccag cgggtaatac gcatctggtg 1140
tgcttcggga cagacgcgaa tcatatccag ccggacgagg acgtgcgcga aacgttgaaa 1200
gccgttggcc aactggcgcc tgggactttc ggtgtcaaac gtctggtctt ccacaactgg 1260
gtaaaggatg aatttgccaa aggcgcgtgg ttcttcagcc gcccaggcat ggtttcagag 1320
tgcctgcagg gtctgcgcga gaaacaccgt ggtgtcgtgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtagttttat cgatggtgct atcgaggagg gcacccgcgc agcgcgtgtt 1440
gtactggagg aactggggac caagcgcgag gtgaaggccc gcctg                 1485

 
<210> 2
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Aspergillus Niger monoamine oxidase (MAON)
 
<400> 2
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Ala Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Thr Ile Gln Phe Ser Pro 
305                 310                 315                 320 
Ala Leu Ser Thr Glu Arg Ile Ser Ala Met Gln Ala Gly His Val Asn 
                325                 330                 335     
Met Cys Thr Lys Val His Ala Glu Val Asp Asn Lys Asp Met Arg Ser 
            340                 345                 350         
Trp Thr Gly Ile Ala Tyr Pro Phe Asn Lys Leu Cys Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Leu Val Cys Phe Gly Thr 
    370                 375                 380                 
Asp Ala Asn His Ile Gln Pro Asp Glu Asp Val Arg Glu Thr Leu Lys 
385                 390                 395                 400 
Ala Val Gly Gln Leu Ala Pro Gly Thr Phe Gly Val Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Val Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ser Arg Pro Gly Met Val Ser Glu Cys Leu Gln Gly Leu Arg Glu Lys 
        435                 440                 445             
His Arg Gly Val Val Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Ser Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Arg Val 
465                 470                 475                 480 
Val Leu Glu Glu Leu Gly Thr Lys Arg Glu Val Lys Ala Arg Leu     
                485                 490                 495     

 
<210> 3
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 3
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gtactattca gtttagccca 960
gcactgtcca cggaacgcat ctccgctatg caggcaggcc atgttaacat gtgcaccaaa 1020
gtgcatgcgg aagtcgataa tcaggatatg cgttcatgga cgggtatcgc ctatccgttc 1080
aacaaattat gctacgctat cggcgatggc acgaccccag cgggtaatac gcatctggtg 1140
tgcttcggga cagacgcgaa tcatatccag ccggacgagg acgtgcgcga aacgttgaaa 1200
gccgttggcc aactggcgcc tgggactttc ggtgtcaaac gtctggtctt ccacaactgg 1260
gtaaaggatg aatttgccaa aggcgcgtgg ttcttcagcc gcccaggcat ggtttcagag 1320
tgcctgcagg gtctgcgcga gaaacaccgt ggtgtcgtgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtagttttat cgatggtgct atcgaggagg gcacccgcgc agcgcgtgtt 1440
gtactggagg aactggggac caagcgcgag gtgaaggccc gcctgtaatg a          1491

 
<210> 4
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 4
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Thr Ile Gln Phe Ser Pro 
305                 310                 315                 320 
Ala Leu Ser Thr Glu Arg Ile Ser Ala Met Gln Ala Gly His Val Asn 
                325                 330                 335     
Met Cys Thr Lys Val His Ala Glu Val Asp Asn Gln Asp Met Arg Ser 
            340                 345                 350         
Trp Thr Gly Ile Ala Tyr Pro Phe Asn Lys Leu Cys Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Leu Val Cys Phe Gly Thr 
    370                 375                 380                 
Asp Ala Asn His Ile Gln Pro Asp Glu Asp Val Arg Glu Thr Leu Lys 
385                 390                 395                 400 
Ala Val Gly Gln Leu Ala Pro Gly Thr Phe Gly Val Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Val Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ser Arg Pro Gly Met Val Ser Glu Cys Leu Gln Gly Leu Arg Glu Lys 
        435                 440                 445             
His Arg Gly Val Val Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Ser Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Arg Val 
465                 470                 475                 480 
Val Leu Glu Glu Leu Gly Thr Lys Arg Glu Val Lys Ala Arg Leu     
                485                 490                 495     

 
<210> 5
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 5
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca ttttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtatctc ctatccgttc 1080
aacaaattag cctacgctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gggcccataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcgtgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
gtaggttggc gtagttttat cgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 6
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 6
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Val Gly Trp Arg 
    450                 455                 460                 
Ser Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 7
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 7
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gtactattca gtttagccca 960
gcactgtcca cggaacgcat ctccgctatg caggcaggcc atgttaacat gtgcaccaaa 1020
gtgcatgcgg aagtcgataa tcaggatatg cgttcatgga cgggtatcgc ctatccgttc 1080
aacaaattat gctacgctat cggcgatggc acgaccccag cgggtaatac gcatctggtg 1140
tgcttcggga cagacgcgaa tcatatccag ccggacgagg acgtgcgcga aacgttgaaa 1200
gccgttggcc aactggcgcc tgggactttc ggtgtcaaac gtctggtctt ccacaactgg 1260
gtaaaggatg aatttgccaa aggcgcgtgg ttcttcagcc gcccaggcat ggtttcagag 1320
tgcctgcagg gtctgcgcga gaaacaccgt ggtgtcgtgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat cgatggtgct atcgaggagg gcacccgcgc agcgcgtgtt 1440
gtactggagg aactggggac caagcgcgag gtgaaggccc gcctgtaatg a          1491

 
<210> 8
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 8
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Thr Ile Gln Phe Ser Pro 
305                 310                 315                 320 
Ala Leu Ser Thr Glu Arg Ile Ser Ala Met Gln Ala Gly His Val Asn 
                325                 330                 335     
Met Cys Thr Lys Val His Ala Glu Val Asp Asn Gln Asp Met Arg Ser 
            340                 345                 350         
Trp Thr Gly Ile Ala Tyr Pro Phe Asn Lys Leu Cys Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Leu Val Cys Phe Gly Thr 
    370                 375                 380                 
Asp Ala Asn His Ile Gln Pro Asp Glu Asp Val Arg Glu Thr Leu Lys 
385                 390                 395                 400 
Ala Val Gly Gln Leu Ala Pro Gly Thr Phe Gly Val Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Val Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ser Arg Pro Gly Met Val Ser Glu Cys Leu Gln Gly Leu Arg Glu Lys 
        435                 440                 445             
His Arg Gly Val Val Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Arg Val 
465                 470                 475                 480 
Val Leu Glu Glu Leu Gly Thr Lys Arg Glu Val Lys Ala Arg Leu     
                485                 490                 495     

 
<210> 9
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 9
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca ttttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtatctc ctatccgttc 1080
aacaaattag cctacgctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gggcccataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcgtgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat cgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 10
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 10
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 11
<211> 1485
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 11
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca ttttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtatctc ctatccgttc 1080
aacaaattag cctacgctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgccttgggg gggcccataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcgtgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat cgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctg                 1485

 
<210> 12
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 12
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Leu Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 13
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 13
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatcaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca ttttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtatctc ctatccgttc 1080
aacaaattag cctgggctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gggcccataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcgtgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat cgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 14
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 14
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Gln Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Trp Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 15
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 15
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatgaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgaccaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca ttttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtatctc ctatccgttc 1080
aacaaattag cctgggctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gcgctcataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcttgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat tgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 16
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 16
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Glu Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Thr Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Trp Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 17
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 17
atgaccagcc gcgacggcta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatgaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgcagaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggctatg tctttggttg tccggtgcgt 840
tctgtggtga acgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca ttttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtatctc ctatccgttc 1080
aacaaattag cctgggctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gcgctcataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcttgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat tgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 18
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 18
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Glu Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Gln Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asn Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Trp Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 19
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 19
atgaccagcc gcgacggtta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatgaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgcagaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggttatg tctttggttg tccggtgcgt 840
tctgtggtgg atgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca gtttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtgtgtc ctatccgttc 1080
aacaaattag cctgggctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gcgctcataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcttgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat tgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 20
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 20
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Glu Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Gln Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asp Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val Gln Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Val Ser Tyr Pro Phe Asn Lys Leu Ala Trp Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     

 
<210> 21
<211> 2271
<212> DNA
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase MAOA
 
<400> 21
atgggaagcc cctctctgta ttctgcccgt aaaacaaccc tggcgttggc agtcgcctta 60
agtttcgcct ggcaagcgcc ggtatttgcc cacggtggtg aagcgcatat ggtgccaatg 120
gataaaacgc ttaaagaatt tggtgccgat gtgcagtggg acgactacgc ccagctcttt 180
accctgatta aagatggcgc gtacgtgaaa gtgaagcctg gtgcgcaaac agcaattgtt 240
aatggtcagc ctctggcact gcaagtaccg gtagtgatga aagacaataa agcctgggtt 300
tctgacacct ttattaacga tgttttccag tccgggctgg atcaaacctt tcaggtagaa 360
aagcgccctc acccacttaa tgcgctaact gcggacgaaa ttaaacaggc cgttgaaatt 420
gttaaagctt ccgcggactt caaacccaat acccgtttta ctgagatctc cctgctaccg 480
ccagataaag aagctgtctg ggcgtttgcg ctggaaaaca aaccggttga ccagccgcgc 540
aaagccgacg tcattatgct cgacggcaaa catatcatcg aagcggtggt ggatctgcaa 600
aacaacaaac tgctctcctg gcaacccatt aaagacgccc acggtatggt gttgctggat 660
gatttcgcca gtgtgcagaa cattattaac aacagtgaag aatttgccgc tgccgtgaag 720
aaacgcggta ttactgatgc gaaaaaagtg attaccacgc cgctgaccgt aggttatttc 780
gatggtaaag atggcctgaa acaagatgcc cggttgctca aagtcatcag ctatcttgat 840
gtcggtgatg gcaactactg ggcacatccc atcgaaaacc tggtggcggt cgttgattta 900
gaacagaaaa aaatcgttaa gattgaagaa ggtccggtag ttccggtgcc aatgaccgca 960
cgcccatttg atggccgtga ccgcgttgct ccggcagtta agcctatgca aatcattgag 1020
cctgaaggta aaaattacac cattactggc gatatgattc actggcggaa ctgggatttt 1080
cacctcagca tgaactctcg cgtcgggccg atgatctcca ccgtgactta taacgacaat 1140
ggcaccaaac gcaaagtcat gtacgaaggt tctctcggcg gcatgattgt gccttacggt 1200
gatcctgata ttggctggta ctttaaagcg tatctggact ctggtgacta cggtatgggc 1260
acgctaacct caccaattgc tcgtggtaaa gatgccccgt ctaacgcagt gctccttaat 1320
gaaaccatcg ccgactacac tggcgtgccg atggagatcc ctcgcgctat cgcggtattt 1380
gaacgttatg ccgggccgga gtataagcat caggaaatgg gccagcccaa cgtcagtacc 1440
gaacgccggg agttagtggt gcgctggatc agtacagtgg gtaactatga ctacattttt 1500
gactggatct tccatgaaaa cggcactatt ggcatcgatg ccggtgctac gggcatcgaa 1560
gcggtgaaag gtgttaaagc gaaaaccatg cacgatgaga cggcgaaaga tgacacgcgc 1620
tacggcacgc ttatcgatca caatatcgtg ggtactacac accaacatat ttataatttc 1680
cgcctcgatc tggatgtaga tggcgagaat aacagcctgg tggcgatgga cccagtggta 1740
aaaccgaata ctgccggtgg cccacgcacc agtaccatgc aagttaatca gtacaacatc 1800
ggcaatgaac aggatgccgc acagaaattt gatccgggca cgattcgtct gttgagtaac 1860
ccgaacaaag agaaccgcat gggcaatccg gtttcctatc aaattattcc ttatgcaggt 1920
ggtactcacc cggtagcaaa aggtgcccag ttcgcgccgg acgagtggat ctatcatcgt 1980
ttaagcttta tggacaagca gctctgggta acgcgttatc atcctggcga gcgtttcccg 2040
gaaggcaaat atccgaaccg ttctactcat gacaccggtc ttggacaata cagtaaggat 2100
aacgagtcgc tggacaacac cgacgccgtt gtctggatga ccaccggcac cacacatgtg 2160
gcccgcgccg aagagtggcc gattatgccg accgaatggg tacatactct gctgaaacca 2220
tggaacttct ttgacgaaac gccaacgcta ggggcgctga agaaagataa g          2271

 
<210> 22
<211> 757
<212> PRT
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase MAOA
 
<400> 22
Met Gly Ser Pro Ser Leu Tyr Ser Ala Arg Lys Thr Thr Leu Ala Leu 
1               5                   10                  15      
Ala Val Ala Leu Ser Phe Ala Trp Gln Ala Pro Val Phe Ala His Gly 
            20                  25                  30          
Gly Glu Ala His Met Val Pro Met Asp Lys Thr Leu Lys Glu Phe Gly 
        35                  40                  45              
Ala Asp Val Gln Trp Asp Asp Tyr Ala Gln Leu Phe Thr Leu Ile Lys 
    50                  55                  60                  
Asp Gly Ala Tyr Val Lys Val Lys Pro Gly Ala Gln Thr Ala Ile Val 
65                  70                  75                  80  
Asn Gly Gln Pro Leu Ala Leu Gln Val Pro Val Val Met Lys Asp Asn 
                85                  90                  95      
Lys Ala Trp Val Ser Asp Thr Phe Ile Asn Asp Val Phe Gln Ser Gly 
            100                 105                 110         
Leu Asp Gln Thr Phe Gln Val Glu Lys Arg Pro His Pro Leu Asn Ala 
        115                 120                 125             
Leu Thr Ala Asp Glu Ile Lys Gln Ala Val Glu Ile Val Lys Ala Ser 
    130                 135                 140                 
Ala Asp Phe Lys Pro Asn Thr Arg Phe Thr Glu Ile Ser Leu Leu Pro 
145                 150                 155                 160 
Pro Asp Lys Glu Ala Val Trp Ala Phe Ala Leu Glu Asn Lys Pro Val 
                165                 170                 175     
Asp Gln Pro Arg Lys Ala Asp Val Ile Met Leu Asp Gly Lys His Ile 
            180                 185                 190         
Ile Glu Ala Val Val Asp Leu Gln Asn Asn Lys Leu Leu Ser Trp Gln 
        195                 200                 205             
Pro Ile Lys Asp Ala His Gly Met Val Leu Leu Asp Asp Phe Ala Ser 
    210                 215                 220                 
Val Gln Asn Ile Ile Asn Asn Ser Glu Glu Phe Ala Ala Ala Val Lys 
225                 230                 235                 240 
Lys Arg Gly Ile Thr Asp Ala Lys Lys Val Ile Thr Thr Pro Leu Thr 
                245                 250                 255     
Val Gly Tyr Phe Asp Gly Lys Asp Gly Leu Lys Gln Asp Ala Arg Leu 
            260                 265                 270         
Leu Lys Val Ile Ser Tyr Leu Asp Val Gly Asp Gly Asn Tyr Trp Ala 
        275                 280                 285             
His Pro Ile Glu Asn Leu Val Ala Val Val Asp Leu Glu Gln Lys Lys 
    290                 295                 300                 
Ile Val Lys Ile Glu Glu Gly Pro Val Val Pro Val Pro Met Thr Ala 
305                 310                 315                 320 
Arg Pro Phe Asp Gly Arg Asp Arg Val Ala Pro Ala Val Lys Pro Met 
                325                 330                 335     
Gln Ile Ile Glu Pro Glu Gly Lys Asn Tyr Thr Ile Thr Gly Asp Met 
            340                 345                 350         
Ile His Trp Arg Asn Trp Asp Phe His Leu Ser Met Asn Ser Arg Val 
        355                 360                 365             
Gly Pro Met Ile Ser Thr Val Thr Tyr Asn Asp Asn Gly Thr Lys Arg 
    370                 375                 380                 
Lys Val Met Tyr Glu Gly Ser Leu Gly Gly Met Ile Val Pro Tyr Gly 
385                 390                 395                 400 
Asp Pro Asp Ile Gly Trp Tyr Phe Lys Ala Tyr Leu Asp Ser Gly Asp 
                405                 410                 415     
Tyr Gly Met Gly Thr Leu Thr Ser Pro Ile Ala Arg Gly Lys Asp Ala 
            420                 425                 430         
Pro Ser Asn Ala Val Leu Leu Asn Glu Thr Ile Ala Asp Tyr Thr Gly 
        435                 440                 445             
Val Pro Met Glu Ile Pro Arg Ala Ile Ala Val Phe Glu Arg Tyr Ala 
    450                 455                 460                 
Gly Pro Glu Tyr Lys His Gln Glu Met Gly Gln Pro Asn Val Ser Thr 
465                 470                 475                 480 
Glu Arg Arg Glu Leu Val Val Arg Trp Ile Ser Thr Val Gly Asn Tyr 
                485                 490                 495     
Asp Tyr Ile Phe Asp Trp Ile Phe His Glu Asn Gly Thr Ile Gly Ile 
            500                 505                 510         
Asp Ala Gly Ala Thr Gly Ile Glu Ala Val Lys Gly Val Lys Ala Lys 
        515                 520                 525             
Thr Met His Asp Glu Thr Ala Lys Asp Asp Thr Arg Tyr Gly Thr Leu 
    530                 535                 540                 
Ile Asp His Asn Ile Val Gly Thr Thr His Gln His Ile Tyr Asn Phe 
545                 550                 555                 560 
Arg Leu Asp Leu Asp Val Asp Gly Glu Asn Asn Ser Leu Val Ala Met 
                565                 570                 575     
Asp Pro Val Val Lys Pro Asn Thr Ala Gly Gly Pro Arg Thr Ser Thr 
            580                 585                 590         
Met Gln Val Asn Gln Tyr Asn Ile Gly Asn Glu Gln Asp Ala Ala Gln 
        595                 600                 605             
Lys Phe Asp Pro Gly Thr Ile Arg Leu Leu Ser Asn Pro Asn Lys Glu 
    610                 615                 620                 
Asn Arg Met Gly Asn Pro Val Ser Tyr Gln Ile Ile Pro Tyr Ala Gly 
625                 630                 635                 640 
Gly Thr His Pro Val Ala Lys Gly Ala Gln Phe Ala Pro Asp Glu Trp 
                645                 650                 655     
Ile Tyr His Arg Leu Ser Phe Met Asp Lys Gln Leu Trp Val Thr Arg 
            660                 665                 670         
Tyr His Pro Gly Glu Arg Phe Pro Glu Gly Lys Tyr Pro Asn Arg Ser 
        675                 680                 685             
Thr His Asp Thr Gly Leu Gly Gln Tyr Ser Lys Asp Asn Glu Ser Leu 
    690                 695                 700                 
Asp Asn Thr Asp Ala Val Val Trp Met Thr Thr Gly Thr Thr His Val 
705                 710                 715                 720 
Ala Arg Ala Glu Glu Trp Pro Ile Met Pro Thr Glu Trp Val His Thr 
                725                 730                 735     
Leu Leu Lys Pro Trp Asn Phe Phe Asp Glu Thr Pro Thr Leu Gly Ala 
            740                 745                 750         
Leu Lys Lys Asp Lys                                             
        755                                                     

 
<210> 23
<211> 2007
<212> DNA
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase putA
 
<400> 23
atgggaacca ccaccatggg ggttaagctg gacgacgcga cgcgtgagcg tattaagtct 60
gccgcgacac gtatcgatcg cacaccacac tggttaatta agcaggcgat tttttcttat 120
ctcgaacaac tggaaaacag cgatactctg ccggagctac ctgcgctgct ttctggcgcg 180
gccaatgaga gcgatgaagc accgactccg gcagaggaac cacaccagcc attcctcgac 240
tttgccgagc aaatattgcc ccagtcggtt tcccgcgccg cgatcaccgc ggcctatcgc 300
cgcccggaaa ccgaagcggt ttctatgctg ctggaacaag cccgcctgcc gcagccagtt 360
gctgaacagg cgcacaaact ggcgtatcag ctggccgata aactgcgtaa tcaaaaaaat 420
gccagtggtc gcgcaggtat ggtccagggg ttattgcagg agttttcgct gtcatcgcag 480
gaaggcgtgg cgctgatgtg tctggcggaa gcgttgttgc gtattcccga caaagccacc 540
cgcgacgcgt taattcgcga caaaatcagc aacggtaact ggcagtcaca cattggtcgt 600
agcccgtcac tgtttgttaa tgccgccacc tgggggctgc tgtttactgg caaactggtt 660
tccacccata acgaagccag cctctcccgc tcgctgaacc gcattatcgg taaaagcggt 720
gaaccgctga tccgcaaagg tgtggatatg gcgatgcgcc tgatgggtga gcagttcgtc 780
actggcgaaa ccatcgcgga agcgttagcc aatgcccgca agctggaaga gaaaggtttc 840
cgttactctt acgatatgct gggcgaagcc gcgctgaccg ccgcagatgc acaggcgtat 900
atggtttcct atcagcaggc gattcacgcc atcggtaaag cgtctaacgg tcgtggcatc 960
tatgaagggc cgggcatttc aatcaaactg tcggcgctgc atccgcgtta tagccgcgcc 1020
cagtatgacc gggtaatgga agagctttac ccgcgtctga aatcactcac cctgctggcg 1080
cgtcagtacg atattggtat caacattgac gccgaagagt ccgatcgcct ggagatctcc 1140
ctcgatctgc tggaaaaact ctgtttcgag ccggaactgg caggctggaa cggcatcggt 1200
tttgttattc aggcttatca aaaacgctgc ccgttggtga tcgattacct gattgatctc 1260
gccacccgca gccgtcgccg tctgatgatt cgcctggtga aaggcgcgta ctgggatagt 1320
gaaattaagc gtgcgcagat ggacggcctt gaaggttatc cggtttatac ccgcaaggtg 1380
tataccgacg tttcttatct cgcctgtgcg aaaaagctgc tggcggtgcc gaatctaatc 1440
tacccgcagt tcgcgacgca caacgcccat acgctggcgg cgatttatca actggcgggg 1500
cagaactact acccgggtca gtacgagttc cagtgcctgc atggtatggg cgagccactg 1560
tatgagcagg tcaccgggaa agttgccgac ggcaaactta accgtccgtg tcgtatttat 1620
gctccggttg gcacacatga aacgctgttg gcgtatctgg tgcgtcgcct gctggaaaac 1680
ggtgctaaca cctcgtttgt taaccgtatt gccgacacct ctttgccact ggatgaactg 1740
gtcgccgatc cggtcactgc tgtagaaaaa ctggcgcaac aggaagggca aactggatta 1800
ccgcatccga aaattcccct gccgcgcgat ctttacggtc acgggcgcga caactcggca 1860
gggctggatc tcgctaacga acaccgcctg gcctcgctct cctctgccct gctcaatagt 1920
gcactgcaaa aatggcaggc cttgccaatg ctggaacaac cggtagcggc aggtgagatg 1980
tcgcccgtta ttaaccctgc ggaaccg                                     2007

 
<210> 24
<211> 669
<212> PRT
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase putA
 
<400> 24
Met Gly Thr Thr Thr Met Gly Val Lys Leu Asp Asp Ala Thr Arg Glu 
1               5                   10                  15      
Arg Ile Lys Ser Ala Ala Thr Arg Ile Asp Arg Thr Pro His Trp Leu 
            20                  25                  30          
Ile Lys Gln Ala Ile Phe Ser Tyr Leu Glu Gln Leu Glu Asn Ser Asp 
        35                  40                  45              
Thr Leu Pro Glu Leu Pro Ala Leu Leu Ser Gly Ala Ala Asn Glu Ser 
    50                  55                  60                  
Asp Glu Ala Pro Thr Pro Ala Glu Glu Pro His Gln Pro Phe Leu Asp 
65                  70                  75                  80  
Phe Ala Glu Gln Ile Leu Pro Gln Ser Val Ser Arg Ala Ala Ile Thr 
                85                  90                  95      
Ala Ala Tyr Arg Arg Pro Glu Thr Glu Ala Val Ser Met Leu Leu Glu 
            100                 105                 110         
Gln Ala Arg Leu Pro Gln Pro Val Ala Glu Gln Ala His Lys Leu Ala 
        115                 120                 125             
Tyr Gln Leu Ala Asp Lys Leu Arg Asn Gln Lys Asn Ala Ser Gly Arg 
    130                 135                 140                 
Ala Gly Met Val Gln Gly Leu Leu Gln Glu Phe Ser Leu Ser Ser Gln 
145                 150                 155                 160 
Glu Gly Val Ala Leu Met Cys Leu Ala Glu Ala Leu Leu Arg Ile Pro 
                165                 170                 175     
Asp Lys Ala Thr Arg Asp Ala Leu Ile Arg Asp Lys Ile Ser Asn Gly 
            180                 185                 190         
Asn Trp Gln Ser His Ile Gly Arg Ser Pro Ser Leu Phe Val Asn Ala 
        195                 200                 205             
Ala Thr Trp Gly Leu Leu Phe Thr Gly Lys Leu Val Ser Thr His Asn 
    210                 215                 220                 
Glu Ala Ser Leu Ser Arg Ser Leu Asn Arg Ile Ile Gly Lys Ser Gly 
225                 230                 235                 240 
Glu Pro Leu Ile Arg Lys Gly Val Asp Met Ala Met Arg Leu Met Gly 
                245                 250                 255     
Glu Gln Phe Val Thr Gly Glu Thr Ile Ala Glu Ala Leu Ala Asn Ala 
            260                 265                 270         
Arg Lys Leu Glu Glu Lys Gly Phe Arg Tyr Ser Tyr Asp Met Leu Gly 
        275                 280                 285             
Glu Ala Ala Leu Thr Ala Ala Asp Ala Gln Ala Tyr Met Val Ser Tyr 
    290                 295                 300                 
Gln Gln Ala Ile His Ala Ile Gly Lys Ala Ser Asn Gly Arg Gly Ile 
305                 310                 315                 320 
Tyr Glu Gly Pro Gly Ile Ser Ile Lys Leu Ser Ala Leu His Pro Arg 
                325                 330                 335     
Tyr Ser Arg Ala Gln Tyr Asp Arg Val Met Glu Glu Leu Tyr Pro Arg 
            340                 345                 350         
Leu Lys Ser Leu Thr Leu Leu Ala Arg Gln Tyr Asp Ile Gly Ile Asn 
        355                 360                 365             
Ile Asp Ala Glu Glu Ser Asp Arg Leu Glu Ile Ser Leu Asp Leu Leu 
    370                 375                 380                 
Glu Lys Leu Cys Phe Glu Pro Glu Leu Ala Gly Trp Asn Gly Ile Gly 
385                 390                 395                 400 
Phe Val Ile Gln Ala Tyr Gln Lys Arg Cys Pro Leu Val Ile Asp Tyr 
                405                 410                 415     
Leu Ile Asp Leu Ala Thr Arg Ser Arg Arg Arg Leu Met Ile Arg Leu 
            420                 425                 430         
Val Lys Gly Ala Tyr Trp Asp Ser Glu Ile Lys Arg Ala Gln Met Asp 
        435                 440                 445             
Gly Leu Glu Gly Tyr Pro Val Tyr Thr Arg Lys Val Tyr Thr Asp Val 
    450                 455                 460                 
Ser Tyr Leu Ala Cys Ala Lys Lys Leu Leu Ala Val Pro Asn Leu Ile 
465                 470                 475                 480 
Tyr Pro Gln Phe Ala Thr His Asn Ala His Thr Leu Ala Ala Ile Tyr 
                485                 490                 495     
Gln Leu Ala Gly Gln Asn Tyr Tyr Pro Gly Gln Tyr Glu Phe Gln Cys 
            500                 505                 510         
Leu His Gly Met Gly Glu Pro Leu Tyr Glu Gln Val Thr Gly Lys Val 
        515                 520                 525             
Ala Asp Gly Lys Leu Asn Arg Pro Cys Arg Ile Tyr Ala Pro Val Gly 
    530                 535                 540                 
Thr His Glu Thr Leu Leu Ala Tyr Leu Val Arg Arg Leu Leu Glu Asn 
545                 550                 555                 560 
Gly Ala Asn Thr Ser Phe Val Asn Arg Ile Ala Asp Thr Ser Leu Pro 
                565                 570                 575     
Leu Asp Glu Leu Val Ala Asp Pro Val Thr Ala Val Glu Lys Leu Ala 
            580                 585                 590         
Gln Gln Glu Gly Gln Thr Gly Leu Pro His Pro Lys Ile Pro Leu Pro 
        595                 600                 605             
Arg Asp Leu Tyr Gly His Gly Arg Asp Asn Ser Ala Gly Leu Asp Leu 
    610                 615                 620                 
Ala Asn Glu His Arg Leu Ala Ser Leu Ser Ser Ala Leu Leu Asn Ser 
625                 630                 635                 640 
Ala Leu Gln Lys Trp Gln Ala Leu Pro Met Leu Glu Gln Pro Val Ala 
                645                 650                 655     
Ala Gly Glu Met Ser Pro Val Ile Asn Pro Ala Glu Pro             
            660                 665                             

 
<210> 25
<211> 1110
<212> DNA
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase goxB 1
 
<400> 25
atgaaaaggc attatgaagc agttgtcatt ggaggcggaa ttattggttc cgcgattgct 60
tatcagttgg caaaagaaaa gaaaaacacc gcattgcttg aaagcggaac aatcggcggc 120
agaacaacaa gcgccgcggc agggatgctt ggcgcccatg ccgagtgcga ggaacgggat 180
gcgttttttg atttcgccat gcacagtcag cgtatgtacc gaggtcttgg agaggagcta 240
tttgcattat ccggtatcga tattagaagg catgatggcg gtatgtttaa gcttgcattc 300
tccgaagaag acgtgtcacg cctcagacgg atggacgatt tggattctgt cagctggcat 360
acaaaagaag aagtgctgga aaaagagccg tatacggcca gtgagattta cggggcgagc 420
tttattcagg atgatgttca tgttgagcct tattttgtat gcaaggcata cgctaaatcg 480
gctaaagcgc ttggtgcgga tatttttgag catactcctg ttctcgatgt gacatgtggc 540
ggtgaatcca ttttggtcaa aacagcgtcc ggtgacatgc atgcggatca tgtcgtggtt 600
gccagcgggg tctggagcgg gatgtttttt aagcagctcg ggctgaatca gtcatttttt 660
cctgtaaaag gagagtgcct gtctgtttgg aatgatgaca ttccgctgac aaaaacactt 720
tatcatgatc attgctatat cgtaccgaga aaaagcggca gactggttgt cggcgcgacg 780
atgaagcctg gtgactggag cgagaaggcg gatcttggcg gacttcagtc ggttatggaa 840
aaagcgaaaa cgatgctgcc ggcgattcag aatatgaagg ttgatcgttt ttgggcggga 900
ctgcgtccgg ggacaaagga cggaaagcca tacattggca agcaccctca ggacagccgc 960
attttatttg cggcgggcca tttcagaaac gggattctgc ttgctcctgc aacgggtgct 1020
ttaattggtg atctcattat gaataaagag gtcaaggcgg actggctgca cgcctttcga 1080
attgatcgca aggaggcggt tcagatatga                                  1110

 
<210> 26
<211> 369
<212> PRT
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase goxB 1
 
<400> 26
Met Lys Arg His Tyr Glu Ala Val Val Ile Gly Gly Gly Ile Ile Gly 
1               5                   10                  15      
Ser Ala Ile Ala Tyr Gln Leu Ala Lys Glu Lys Lys Asn Thr Ala Leu 
            20                  25                  30          
Leu Glu Ser Gly Thr Ile Gly Gly Arg Thr Thr Ser Ala Ala Ala Gly 
        35                  40                  45              
Met Leu Gly Ala His Ala Glu Cys Glu Glu Arg Asp Ala Phe Phe Asp 
    50                  55                  60                  
Phe Ala Met His Ser Gln Arg Met Tyr Arg Gly Leu Gly Glu Glu Leu 
65                  70                  75                  80  
Phe Ala Leu Ser Gly Ile Asp Ile Arg Arg His Asp Gly Gly Met Phe 
                85                  90                  95      
Lys Leu Ala Phe Ser Glu Glu Asp Val Ser Arg Leu Arg Arg Met Asp 
            100                 105                 110         
Asp Leu Asp Ser Val Ser Trp His Thr Lys Glu Glu Val Leu Glu Lys 
        115                 120                 125             
Glu Pro Tyr Thr Ala Ser Glu Ile Tyr Gly Ala Ser Phe Ile Gln Asp 
    130                 135                 140                 
Asp Val His Val Glu Pro Tyr Phe Val Cys Lys Ala Tyr Ala Lys Ser 
145                 150                 155                 160 
Ala Lys Ala Leu Gly Ala Asp Ile Phe Glu His Thr Pro Val Leu Asp 
                165                 170                 175     
Val Thr Cys Gly Gly Glu Ser Ile Leu Val Lys Thr Ala Ser Gly Asp 
            180                 185                 190         
Met His Ala Asp His Val Val Val Ala Ser Gly Val Trp Ser Gly Met 
        195                 200                 205             
Phe Phe Lys Gln Leu Gly Leu Asn Gln Ser Phe Phe Pro Val Lys Gly 
    210                 215                 220                 
Glu Cys Leu Ser Val Trp Asn Asp Asp Ile Pro Leu Thr Lys Thr Leu 
225                 230                 235                 240 
Tyr His Asp His Cys Tyr Ile Val Pro Arg Lys Ser Gly Arg Leu Val 
                245                 250                 255     
Val Gly Ala Thr Met Lys Pro Gly Asp Trp Ser Glu Lys Ala Asp Leu 
            260                 265                 270         
Gly Gly Leu Gln Ser Val Met Glu Lys Ala Lys Thr Met Leu Pro Ala 
        275                 280                 285             
Ile Gln Asn Met Lys Val Asp Arg Phe Trp Ala Gly Leu Arg Pro Gly 
    290                 295                 300                 
Thr Lys Asp Gly Lys Pro Tyr Ile Gly Lys His Pro Gln Asp Ser Arg 
305                 310                 315                 320 
Ile Leu Phe Ala Ala Gly His Phe Arg Asn Gly Ile Leu Leu Ala Pro 
                325                 330                 335     
Ala Thr Gly Ala Leu Ile Gly Asp Leu Ile Met Asn Lys Glu Val Lys 
            340                 345                 350         
Ala Asp Trp Leu His Ala Phe Arg Ile Asp Arg Lys Glu Ala Val Gln 
        355                 360                 365             
Ile                                                             
                                                                

 
<210> 27
<211> 1110
<212> DNA
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase goxB 5
 
<400> 27
atgaaaaggc attatgaagc agtggtgatt ggaggcggaa ttatcggttc cgcaattgct 60
tattatttgg caaaggaaaa caaaaacacc gcattgtttg aaagcggaac aatgggcggc 120
agaacgacaa gtgccgctgc cggaatgctg ggcgcccatg ccgaatgcga ggaacgtgac 180
gcgttttttg atttcgccat gcacagccag cgtctgtaca aaggtcttgg agaagagctt 240
tatgcattat ccggtgtgga tatcaggcag cataacggcg gtatgtttaa gcttgcattt 300
tctgaagaag atgtgctgca gctgagacag atggacgatt tggactctgt cagctggtat 360
tcaaaagaag aggtgttaga aaaagagccg tatgcgtctg gtgacatctt tggtgcatct 420
tttattcagg atgatgtgca tgtggagcct tattttgttt gcaaggcata tgtgaaagca 480
gcaaaaatgc ttggggcgga gatttttgag catacgcccg tcctgcatgt cgaacgtgac 540
ggtgaagccc tgtccatcaa gacccctagc ggagacgtat gggctaatca tgttgtcgtt 600
gccagcgggg tgtggagcgg aatgtttttt aaacagcttg gactgaacaa tgcttttctc 660
cctgtaaaag gggagtgcct gtccgtttgg aatgatgata tcccgctgac aaaaacgctt 720
taccatgatc actgctatat cgtaccgaga aaaagcggca aactggttgt cggcgcgaca 780
atgaagccgg gggactggag tgaaacaccg gatcttggcg gattggaatc cgttatgaaa 840
aaagcaaaaa cgatgctgcc ggctatacag aatatgaagg tggatcgttt ttgggcggga 900
ctccgtccgg gaacaaagga tggaaaaccg tacatcggca gacatcctga ggacagccgt 960
attttatttg cggctggcca tttcagaaat gggatcctgc ttgctcccgc aacgggcgct 1020
ttgatcagtg atctcatcat gaataaagag gtcaaccaag actggctgca cgcattccga 1080
attgatcgca aggaggcggt tcagatatga                                  1110

 
<210> 28
<211> 369
<212> PRT
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase goxB 5
 
<400> 28
Met Lys Arg His Tyr Glu Ala Val Val Ile Gly Gly Gly Ile Ile Gly 
1               5                   10                  15      
Ser Ala Ile Ala Tyr Tyr Leu Ala Lys Glu Asn Lys Asn Thr Ala Leu 
            20                  25                  30          
Phe Glu Ser Gly Thr Met Gly Gly Arg Thr Thr Ser Ala Ala Ala Gly 
        35                  40                  45              
Met Leu Gly Ala His Ala Glu Cys Glu Glu Arg Asp Ala Phe Phe Asp 
    50                  55                  60                  
Phe Ala Met His Ser Gln Arg Leu Tyr Lys Gly Leu Gly Glu Glu Leu 
65                  70                  75                  80  
Tyr Ala Leu Ser Gly Val Asp Ile Arg Gln His Asn Gly Gly Met Phe 
                85                  90                  95      
Lys Leu Ala Phe Ser Glu Glu Asp Val Leu Gln Leu Arg Gln Met Asp 
            100                 105                 110         
Asp Leu Asp Ser Val Ser Trp Tyr Ser Lys Glu Glu Val Leu Glu Lys 
        115                 120                 125             
Glu Pro Tyr Ala Ser Gly Asp Ile Phe Gly Ala Ser Phe Ile Gln Asp 
    130                 135                 140                 
Asp Val His Val Glu Pro Tyr Phe Val Cys Lys Ala Tyr Val Lys Ala 
145                 150                 155                 160 
Ala Lys Met Leu Gly Ala Glu Ile Phe Glu His Thr Pro Val Leu His 
                165                 170                 175     
Val Glu Arg Asp Gly Glu Ala Leu Ser Ile Lys Thr Pro Ser Gly Asp 
            180                 185                 190         
Val Trp Ala Asn His Val Val Val Ala Ser Gly Val Trp Ser Gly Met 
        195                 200                 205             
Phe Phe Lys Gln Leu Gly Leu Asn Asn Ala Phe Leu Pro Val Lys Gly 
    210                 215                 220                 
Glu Cys Leu Ser Val Trp Asn Asp Asp Ile Pro Leu Thr Lys Thr Leu 
225                 230                 235                 240 
Tyr His Asp His Cys Tyr Ile Val Pro Arg Lys Ser Gly Lys Leu Val 
                245                 250                 255     
Val Gly Ala Thr Met Lys Pro Gly Asp Trp Ser Glu Thr Pro Asp Leu 
            260                 265                 270         
Gly Gly Leu Glu Ser Val Met Lys Lys Ala Lys Thr Met Leu Pro Ala 
        275                 280                 285             
Ile Gln Asn Met Lys Val Asp Arg Phe Trp Ala Gly Leu Arg Pro Gly 
    290                 295                 300                 
Thr Lys Asp Gly Lys Pro Tyr Ile Gly Arg His Pro Glu Asp Ser Arg 
305                 310                 315                 320 
Ile Leu Phe Ala Ala Gly His Phe Arg Asn Gly Ile Leu Leu Ala Pro 
                325                 330                 335     
Ala Thr Gly Ala Leu Ile Ser Asp Leu Ile Met Asn Lys Glu Val Asn 
            340                 345                 350         
Gln Asp Trp Leu His Ala Phe Arg Ile Asp Arg Lys Glu Ala Val Gln 
        355                 360                 365             
Ile                                                             
                                                                

 
<210> 29
<211> 1479
<212> DNA
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase MAO-2
 
<400> 29
atgaccaccc aggacggctg tcattatcac attaacgagg gtctgaccca tggcgtaccg 60
tcccgtgcta aaatttatcc ggcggaacgc ctggcacagg gccagcagac cttggatacc 120
attgtcattg gggccgggta tgctgggctg atcgcagccc gtaatttagc cctgcaaggg 180
aaacgtgtgg tgctgctgga ggcccgtgat cgtattggtg gccgcacctt taccagtgat 240
attgacggtt acgggtatga gatgggtggc aattggattc attggggtca acctcacgtg 300
tatgctgaag tctcgcgtta tagcatggcc aacgagctgg tttcatcaca ggactataca 360
tatgaagagg gtaactactg ctcgactatg attcatggcg tcggtgggcg cctgacgcac 420
caagaggagg aacatattgg ggaaaccgca atgtctattt tctgcaatgt cgacggtcag 480
gatggccgtg gggtggtgcc gttcccacat aatgcgactc ataacgcgga ggcatttgcc 540
acgtgggaca aagtgtcatg tcaggatcgc ctggaccaga tcaaagacaa actgtctccg 600
ctgcaactgg cttttttaac gtctaccctg atgcatatta gcggtgccaa caacgaagac 660
gtcagcgttg ctgaattgct gcgttggtgg gcactgtgcg attaccgtaa ttcgggcatt 720
acggattatg ggctgttgta taaattgaag tgtggccaga ctgggttggc gaaagccatc 780
tttaacgaag gcgttctgct gggcaatctg cagtataaat ttagtgctcc ggtggttact 840
attcgtgacg aaggcgcctc agtagaagtt accacacgtg gcggtcagca attccgtgcg 900
aaaactgtga ttagcacgat tccgctgaac gtattgagtt ctattcagtt taccccacca 960
ctgcctacgg ggaaagtctt ggctgcgcgt caaggccatg ttaacaaggc caccaaaacg 1020
cattttgaag tcgaaggtac ggctatgcgt tcatggtcgg gtgtcgccta tccgtccaaa 1080
gggcaaatgt acctgtacgg cgatggcctg accccagcgg gtaatacgca tattattgcc 1140
ttcgggccag acccggaact gctggcgggc aaggacgtgg aaaaaattaa gggggccctg 1200
acccatgtga aggatgccga agtcaaacgt attgtcttcc acgactggaa ccaggatgaa 1260
ttttcccaag gcacgtgggc cgtctaccct ccaaactttg ctacaaagta cctggataat 1320
ctgcagaagc cagtcggtcg tatccatttt gcaagcgccg attgggccga aggttggcgt 1380
ggttttatcg atggtgctat cgagcagggc gtccgcgcat cgctggctgt atcgaaggaa 1440
ctggcgagcc atcgcgcggc gccgaaacgt tcccacctg                        1479

 
<210> 30
<211> 493
<212> PRT
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase MAO-2
 
<400> 30
Met Thr Thr Gln Asp Gly Cys His Tyr His Ile Asn Glu Gly Leu Thr 
1               5                   10                  15      
His Gly Val Pro Ser Arg Ala Lys Ile Tyr Pro Ala Glu Arg Leu Ala 
            20                  25                  30          
Gln Gly Gln Gln Thr Leu Asp Thr Ile Val Ile Gly Ala Gly Tyr Ala 
        35                  40                  45              
Gly Leu Ile Ala Ala Arg Asn Leu Ala Leu Gln Gly Lys Arg Val Val 
    50                  55                  60                  
Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Thr Phe Thr Ser Asp 
65                  70                  75                  80  
Ile Asp Gly Tyr Gly Tyr Glu Met Gly Gly Asn Trp Ile His Trp Gly 
                85                  90                  95      
Gln Pro His Val Tyr Ala Glu Val Ser Arg Tyr Ser Met Ala Asn Glu 
            100                 105                 110         
Leu Val Ser Ser Gln Asp Tyr Thr Tyr Glu Glu Gly Asn Tyr Cys Ser 
        115                 120                 125             
Thr Met Ile His Gly Val Gly Gly Arg Leu Thr His Gln Glu Glu Glu 
    130                 135                 140                 
His Ile Gly Glu Thr Ala Met Ser Ile Phe Cys Asn Val Asp Gly Gln 
145                 150                 155                 160 
Asp Gly Arg Gly Val Val Pro Phe Pro His Asn Ala Thr His Asn Ala 
                165                 170                 175     
Glu Ala Phe Ala Thr Trp Asp Lys Val Ser Cys Gln Asp Arg Leu Asp 
            180                 185                 190         
Gln Ile Lys Asp Lys Leu Ser Pro Leu Gln Leu Ala Phe Leu Thr Ser 
        195                 200                 205             
Thr Leu Met His Ile Ser Gly Ala Asn Asn Glu Asp Val Ser Val Ala 
    210                 215                 220                 
Glu Leu Leu Arg Trp Trp Ala Leu Cys Asp Tyr Arg Asn Ser Gly Ile 
225                 230                 235                 240 
Thr Asp Tyr Gly Leu Leu Tyr Lys Leu Lys Cys Gly Gln Thr Gly Leu 
                245                 250                 255     
Ala Lys Ala Ile Phe Asn Glu Gly Val Leu Leu Gly Asn Leu Gln Tyr 
            260                 265                 270         
Lys Phe Ser Ala Pro Val Val Thr Ile Arg Asp Glu Gly Ala Ser Val 
        275                 280                 285             
Glu Val Thr Thr Arg Gly Gly Gln Gln Phe Arg Ala Lys Thr Val Ile 
    290                 295                 300                 
Ser Thr Ile Pro Leu Asn Val Leu Ser Ser Ile Gln Phe Thr Pro Pro 
305                 310                 315                 320 
Leu Pro Thr Gly Lys Val Leu Ala Ala Arg Gln Gly His Val Asn Lys 
                325                 330                 335     
Ala Thr Lys Thr His Phe Glu Val Glu Gly Thr Ala Met Arg Ser Trp 
            340                 345                 350         
Ser Gly Val Ala Tyr Pro Ser Lys Gly Gln Met Tyr Leu Tyr Gly Asp 
        355                 360                 365             
Gly Leu Thr Pro Ala Gly Asn Thr His Ile Ile Ala Phe Gly Pro Asp 
    370                 375                 380                 
Pro Glu Leu Leu Ala Gly Lys Asp Val Glu Lys Ile Lys Gly Ala Leu 
385                 390                 395                 400 
Thr His Val Lys Asp Ala Glu Val Lys Arg Ile Val Phe His Asp Trp 
                405                 410                 415     
Asn Gln Asp Glu Phe Ser Gln Gly Thr Trp Ala Val Tyr Pro Pro Asn 
            420                 425                 430         
Phe Ala Thr Lys Tyr Leu Asp Asn Leu Gln Lys Pro Val Gly Arg Ile 
        435                 440                 445             
His Phe Ala Ser Ala Asp Trp Ala Glu Gly Trp Arg Gly Phe Ile Asp 
    450                 455                 460                 
Gly Ala Ile Glu Gln Gly Val Arg Ala Ser Leu Ala Val Ser Lys Glu 
465                 470                 475                 480 
Leu Ala Ser His Arg Ala Ala Pro Lys Arg Ser His Leu             
                485                 490                         

 
<210> 31
<211> 1479
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Aspergillus oryzae monoamine oxidase (MAO-3)
 
<400> 31
atgaccagcc gcgacggcta tcagtggacc gcgacaacgg gtctgcgcca gggcgtaccg 60
tccattggtg tcatttcgcc gccgactaac gtcttaagta ccactgagga ctgggatgtc 120
gttgtcgttg gggccgggta ttctgggctg accgcaagcc gtgatgcatg cctggcaggg 180
ttgaaggtgc tgctgattga ggcccgtgat cgtattggtg gccgctcctg gagcagtaat 240
attggcggtt acccgtttga gatgggtggc acttggctgt cttggggtca acctcacatt 300
tggcgtgaag tctcgcgtta tcaaatgcgc agcgagctgg aaccatgctt tgacttttca 360
cgtggcgtga atcacttcga actgcgtacc ggttcgcagg gcagttcgat cttttcgcac 420
ttagaggagg atgcactgct ggctagcgca ttggaaaaat tcgtcgatgt cgacggcgct 480
atgggccgtc aaattattcc gtacccacat gatgcgtttc ataacccggc agctcgccag 540
tatgacgata tgtcagcttt ggatcgcctg aacgcgctgg cccagagcct gactccgaac 600
gaacgcgctg ttttagagtc tttcatttta ttatgtagct gtggcaccct ggaaaccacc 660
agcttttttg aatttctgca ttggtgggca ctgtgcgatt actcgtataa gggctgtctg 720
cagcatttaa tctcctataa atttaagggt ggccagagtt cgttcgcgat taaattcttt 780
cgtgaatccc tgcgcactgg ccgtctgagc tatgccttta attctccggt gcagtctatt 840
aacgaccatg gcgaccgtgt agttgttaaa acacgtgacg gtcgccaata ctcaggggca 900
cgtttgatta gcacgattcc gctgaacgta ttgagttctg ttcattttag cccaccactg 960
tccccgcaac gcatggccgc tgcgaacatt ggccatgtta accagtgcgt caaagtgcat 1020
gcggaagtca gttgtccgga tatgcgttca tggtcgggta tctcctatcc gttcaacaaa 1080
ttagcctacg ctatcggcga tggcacgacc ccagcgggta atacgcatat tgtgtgcttc 1140
gggggggccc ataatcatat ccagccggaa gaggacgtgg aagcaacgaa gatggccgtt 1200
gaaaacatgt cgcctgggaa tatggatatc aaacgtctgg tcttccacaa ctggtgcaag 1260
gatgaatttg ccaaaggcgc gtggttcttc gcccctccac agctgctgtc aaagagcctg 1320
gatgaactgc gctgccgtca cggtaatgtc ctgtttgcaa actccgattg ggccgtaggt 1380
tggcgtagtt ttatcgatgg tgctatcgag gagggcaccc gcgcagcggt tactgtaatt 1440
gaggaactgc gtcctgcgcc tgcggtgcgt tcccacctg                        1479

 
<210> 32
<211> 493
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Aspergillus oryzae monoamine oxidase (MAO-3)
 
<400> 32
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Ala Thr Thr Gly Leu Arg 
1               5                   10                  15      
Gln Gly Val Pro Ser Ile Gly Val Ile Ser Pro Pro Thr Asn Val Leu 
            20                  25                  30          
Ser Thr Thr Glu Asp Trp Asp Val Val Val Val Gly Ala Gly Tyr Ser 
        35                  40                  45              
Gly Leu Thr Ala Ser Arg Asp Ala Cys Leu Ala Gly Leu Lys Val Leu 
    50                  55                  60                  
Leu Ile Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser Ser Asn 
65                  70                  75                  80  
Ile Gly Gly Tyr Pro Phe Glu Met Gly Gly Thr Trp Leu Ser Trp Gly 
                85                  90                  95      
Gln Pro His Ile Trp Arg Glu Val Ser Arg Tyr Gln Met Arg Ser Glu 
            100                 105                 110         
Leu Glu Pro Cys Phe Asp Phe Ser Arg Gly Val Asn His Phe Glu Leu 
        115                 120                 125             
Arg Thr Gly Ser Gln Gly Ser Ser Ile Phe Ser His Leu Glu Glu Asp 
    130                 135                 140                 
Ala Leu Leu Ala Ser Ala Leu Glu Lys Phe Val Asp Val Asp Gly Ala 
145                 150                 155                 160 
Met Gly Arg Gln Ile Ile Pro Tyr Pro His Asp Ala Phe His Asn Pro 
                165                 170                 175     
Ala Ala Arg Gln Tyr Asp Asp Met Ser Ala Leu Asp Arg Leu Asn Ala 
            180                 185                 190         
Leu Ala Gln Ser Leu Thr Pro Asn Glu Arg Ala Val Leu Glu Ser Phe 
        195                 200                 205             
Ile Leu Leu Cys Ser Cys Gly Thr Leu Glu Thr Thr Ser Phe Phe Glu 
    210                 215                 220                 
Phe Leu His Trp Trp Ala Leu Cys Asp Tyr Ser Tyr Lys Gly Cys Leu 
225                 230                 235                 240 
Gln His Leu Ile Ser Tyr Lys Phe Lys Gly Gly Gln Ser Ser Phe Ala 
                245                 250                 255     
Ile Lys Phe Phe Arg Glu Ser Leu Arg Thr Gly Arg Leu Ser Tyr Ala 
            260                 265                 270         
Phe Asn Ser Pro Val Gln Ser Ile Asn Asp His Gly Asp Arg Val Val 
        275                 280                 285             
Val Lys Thr Arg Asp Gly Arg Gln Tyr Ser Gly Ala Arg Leu Ile Ser 
    290                 295                 300                 
Thr Ile Pro Leu Asn Val Leu Ser Ser Val His Phe Ser Pro Pro Leu 
305                 310                 315                 320 
Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn Gln Cys 
                325                 330                 335     
Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser Trp Ser 
            340                 345                 350         
Gly Ile Ser Tyr Pro Phe Asn Lys Leu Ala Tyr Ala Ile Gly Asp Gly 
        355                 360                 365             
Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly Ala His 
    370                 375                 380                 
Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met Ala Val 
385                 390                 395                 400 
Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val Phe His 
                405                 410                 415     
Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe Ala Pro 
            420                 425                 430         
Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg His Gly 
        435                 440                 445             
Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Val Gly Trp Arg Ser Phe 
    450                 455                 460                 
Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr Val Ile 
465                 470                 475                 480 
Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu             
                485                 490                         

 
<210> 33
<211> 1476
<212> DNA
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase MAO-4
 
<400> 33
atgaccagcc gcgacggcta tcagtggacc gcggaaacgg gtctggtcca gggcgtaccg 60
tccattagtg tcatttcgcc gccgactaac atcagccctg aaagtcgtca gtatgatgtc 120
gttgtcgttg gggccgggta ttctgggctg accgcagccc gtgatacatg cctggcaggg 180
ttgaaggtgc tgctgctgga ggcccgtgat cgtattggtg gccgctcctg gagcagtgat 240
attggcggtt acccgtttga gatgggtggc acttgggttc attggggtca acctcacgtg 300
tggcgtgaaa tctcgcgtta tcaaatgcgc aacgagctgg aatcatcatt tgacttttca 360
cgtggcgtga atcacttcga actgcgtacc aatcagggcc ctgcgatcat gtcgcacaaa 420
gaggaggatg aactgctggc tgccgcattg cataaattcg tcgatgtcga cggcgatctg 480
ggccgtcgtg cggtgccgtt cccacatgat tcgtttcatg tgccggaagc tcgccagtat 540
gaccaaatgt cagctaaaga tcgcatgacc cagatcgccg acacagtgtc tccgcgcgaa 600
cgcgctgctt tagagtcttt cgttttatta tgtagcggtg gcaccctggc aaccaccagc 660
ttttttgaat ttctgcattg gtgggcactg tgcggttact cgtatcaggg ctgtctggat 720
gctttaatct cctataaatt taagcgtggc cagagttcgt tcgcgctgcg cttctttcgt 780
gaagccctga gcactggcaa tctgagctat gcctttaatt ctccgattca gtctattgat 840
gaccaaggcg ccaaagtagt tgttaccaca cgtgaaggtc accgttacgc aggggcacgt 900
ttgattagca cgattccgct gaacgtattg aatactgtta cgattagccc accactgggc 960
acgcaacgca ccgccgctgc gaacacaggc catgttaacc agtgcgtcaa agtgcatgcg 1020
gaaatcgcta gtcgtgatat gcgttcatgg acgggtatct cctatccgtt caacaaatta 1080
tgctacgcta tcggcgatgg cacgacccca gcgggtaata cgcatattgt gtgcttcggg 1140
gggagccata atcatatcca gccggaagag gacattaaac aaacgaagac agccgttgaa 1200
tcactgtcgc ctgggaatat ggatatcaaa cgtctggtct tccacaactg gtcaaaggat 1260
gaatttgcca aaggcgcgtg gttcttcagc cctccagaaa tgctgtcaac gagcctggag 1320
gctctgcgca gccgtcacgg taatgtcgtg ttggcaaact ccgattgggc cttaggttgg 1380
cgtagtttta tcgatggtgc tatcgaggag ggcacccgcg cagcgatgac tgtagtggag 1440
gaactgcgtc ctcagcctgc ggtgcgtgaa cacctg                           1476

 
<210> 34
<211> 492
<212> PRT
<213> Artificial Sequence
 
<220>
<223> monoamine oxidase MAO-4
 
<400> 34
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Ala Glu Thr Gly Leu Val 
1               5                   10                  15      
Gln Gly Val Pro Ser Ile Ser Val Ile Ser Pro Pro Thr Asn Ile Ser 
            20                  25                  30          
Pro Glu Ser Arg Gln Tyr Asp Val Val Val Val Gly Ala Gly Tyr Ser 
        35                  40                  45              
Gly Leu Thr Ala Ala Arg Asp Thr Cys Leu Ala Gly Leu Lys Val Leu 
    50                  55                  60                  
Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser Ser Asp 
65                  70                  75                  80  
Ile Gly Gly Tyr Pro Phe Glu Met Gly Gly Thr Trp Val His Trp Gly 
                85                  90                  95      
Gln Pro His Val Trp Arg Glu Ile Ser Arg Tyr Gln Met Arg Asn Glu 
            100                 105                 110         
Leu Glu Ser Ser Phe Asp Phe Ser Arg Gly Val Asn His Phe Glu Leu 
        115                 120                 125             
Arg Thr Asn Gln Gly Pro Ala Ile Met Ser His Lys Glu Glu Asp Glu 
    130                 135                 140                 
Leu Leu Ala Ala Ala Leu His Lys Phe Val Asp Val Asp Gly Asp Leu 
145                 150                 155                 160 
Gly Arg Arg Ala Val Pro Phe Pro His Asp Ser Phe His Val Pro Glu 
                165                 170                 175     
Ala Arg Gln Tyr Asp Gln Met Ser Ala Lys Asp Arg Met Thr Gln Ile 
            180                 185                 190         
Ala Asp Thr Val Ser Pro Arg Glu Arg Ala Ala Leu Glu Ser Phe Val 
        195                 200                 205             
Leu Leu Cys Ser Gly Gly Thr Leu Ala Thr Thr Ser Phe Phe Glu Phe 
    210                 215                 220                 
Leu His Trp Trp Ala Leu Cys Gly Tyr Ser Tyr Gln Gly Cys Leu Asp 
225                 230                 235                 240 
Ala Leu Ile Ser Tyr Lys Phe Lys Arg Gly Gln Ser Ser Phe Ala Leu 
                245                 250                 255     
Arg Phe Phe Arg Glu Ala Leu Ser Thr Gly Asn Leu Ser Tyr Ala Phe 
            260                 265                 270         
Asn Ser Pro Ile Gln Ser Ile Asp Asp Gln Gly Ala Lys Val Val Val 
        275                 280                 285             
Thr Thr Arg Glu Gly His Arg Tyr Ala Gly Ala Arg Leu Ile Ser Thr 
    290                 295                 300                 
Ile Pro Leu Asn Val Leu Asn Thr Val Thr Ile Ser Pro Pro Leu Gly 
305                 310                 315                 320 
Thr Gln Arg Thr Ala Ala Ala Asn Thr Gly His Val Asn Gln Cys Val 
                325                 330                 335     
Lys Val His Ala Glu Ile Ala Ser Arg Asp Met Arg Ser Trp Thr Gly 
            340                 345                 350         
Ile Ser Tyr Pro Phe Asn Lys Leu Cys Tyr Ala Ile Gly Asp Gly Thr 
        355                 360                 365             
Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly Ser His Asn 
    370                 375                 380                 
His Ile Gln Pro Glu Glu Asp Ile Lys Gln Thr Lys Thr Ala Val Glu 
385                 390                 395                 400 
Ser Leu Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val Phe His Asn 
                405                 410                 415     
Trp Ser Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe Ser Pro Pro 
            420                 425                 430         
Glu Met Leu Ser Thr Ser Leu Glu Ala Leu Arg Ser Arg His Gly Asn 
        435                 440                 445             
Val Val Leu Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg Ser Phe Ile 
    450                 455                 460                 
Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Met Thr Val Val Glu 
465                 470                 475                 480 
Glu Leu Arg Pro Gln Pro Ala Val Arg Glu His Leu                 
                485                 490                         

 
<210> 35
<211> 1491
<212> DNA
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 35
atgaccagcc gcgacggtta tcagtggacc ccggaaacgg gtctgaccca gggcgtaccg 60
tccctgggtg tcatttcgcc gccgactaac atcgaagata ccgataagga cgggccttgg 120
gatgtcattg tcattggggg cgggtattgt gggctgaccg caacccgtga tttaaccgtc 180
gcagggttca agacgctgct gctggaggcc cgtgatcgta ttggtggccg ctcctggagc 240
agtaatattg acggttaccc gtatgagatg ggtggcactt gggttcattg gcatgaatct 300
cacgtgtggc gtgaaatcac gcgttataaa atgcacaacg cgctgtctcc atcatttaac 360
ttttcacgtg gcgtgaatca cttccaactg cgtaccaatc cgcagaccag tacgtacatg 420
acgcacgaag cggaggatga actgctgcgt agcgcattgc ataaattcac caatgtcgac 480
ggcactaatg gccgtacagt gttgccgttc ccacatgata tgttttatgt gccggaattt 540
cgcaagtatg acgaaatgtc atattccgaa cgcattgacc agatccgcga cgaactgtct 600
ttgaacgaac gctctagttt agaggctttc attttattat gtagcggtgg caccctggaa 660
aactccagct ttggtgaatt tctgcattgg tgggcaatgt cgggttacac gtatcagggc 720
tgtatggatt gtttaatctc ctataaattt aaggatggcc agagtgcgtt cgcgcgtcgc 780
ttctgggaag aagccgctgg cactggccgt ctgggttatg tctttggttg tccggtgcgt 840
tctgtggtgg atgaacgcga cgcagtacgt gttaccgcac gtgacggtcg cgaattcgca 900
gcgaaacgtt tggtttgcac gattccgctg aacgtattga gttctgttca gtttagccca 960
ccactgtccc cgcaacgcat ggccgctgcg aacattggcc atgttaacca gtgcgtcaaa 1020
gtgcatgcgg aagtcagttg tccggatatg cgttcatggt cgggtgtgtc ctatccgttc 1080
aacaaattag cctacgctat cggcgatggc acgaccccag cgggtaatac gcatattgtg 1140
tgcttcgggg gcgctcataa tcatatccag ccggaagagg acgtggaagc aacgaagatg 1200
gccgttgaaa acatgtcgcc tgggaatatg gatatcaaac gtctggtctt ccacaactgg 1260
tgcaaggatg aatttgccaa aggcgcttgg ttcttcgccc ctccacagct gctgtcaaag 1320
agcctggatg aactgcgctg ccgtcacggt aatgtcctgt ttgcaaactc cgattgggcc 1380
ttaggttggc gtggttttat tgatggtgct atcgaggagg gcacccgcgc agcggttact 1440
gtaattgagg aactgcgtcc tgcgcctgcg gtgcgttccc acctgtaatg a          1491

 
<210> 36
<211> 495
<212> PRT
<213> Artificial Sequence
 
<220>
<223> variant monoamine oxidase
 
<400> 36
Met Thr Ser Arg Asp Gly Tyr Gln Trp Thr Pro Glu Thr Gly Leu Thr 
1               5                   10                  15      
Gln Gly Val Pro Ser Leu Gly Val Ile Ser Pro Pro Thr Asn Ile Glu 
            20                  25                  30          
Asp Thr Asp Lys Asp Gly Pro Trp Asp Val Ile Val Ile Gly Gly Gly 
        35                  40                  45              
Tyr Cys Gly Leu Thr Ala Thr Arg Asp Leu Thr Val Ala Gly Phe Lys 
    50                  55                  60                  
Thr Leu Leu Leu Glu Ala Arg Asp Arg Ile Gly Gly Arg Ser Trp Ser 
65                  70                  75                  80  
Ser Asn Ile Asp Gly Tyr Pro Tyr Glu Met Gly Gly Thr Trp Val His 
                85                  90                  95      
Trp His Glu Ser His Val Trp Arg Glu Ile Thr Arg Tyr Lys Met His 
            100                 105                 110         
Asn Ala Leu Ser Pro Ser Phe Asn Phe Ser Arg Gly Val Asn His Phe 
        115                 120                 125             
Gln Leu Arg Thr Asn Pro Gln Thr Ser Thr Tyr Met Thr His Glu Ala 
    130                 135                 140                 
Glu Asp Glu Leu Leu Arg Ser Ala Leu His Lys Phe Thr Asn Val Asp 
145                 150                 155                 160 
Gly Thr Asn Gly Arg Thr Val Leu Pro Phe Pro His Asp Met Phe Tyr 
                165                 170                 175     
Val Pro Glu Phe Arg Lys Tyr Asp Glu Met Ser Tyr Ser Glu Arg Ile 
            180                 185                 190         
Asp Gln Ile Arg Asp Glu Leu Ser Leu Asn Glu Arg Ser Ser Leu Glu 
        195                 200                 205             
Ala Phe Ile Leu Leu Cys Ser Gly Gly Thr Leu Glu Asn Ser Ser Phe 
    210                 215                 220                 
Gly Glu Phe Leu His Trp Trp Ala Met Ser Gly Tyr Thr Tyr Gln Gly 
225                 230                 235                 240 
Cys Met Asp Cys Leu Ile Ser Tyr Lys Phe Lys Asp Gly Gln Ser Ala 
                245                 250                 255     
Phe Ala Arg Arg Phe Trp Glu Glu Ala Ala Gly Thr Gly Arg Leu Gly 
            260                 265                 270         
Tyr Val Phe Gly Cys Pro Val Arg Ser Val Val Asp Glu Arg Asp Ala 
        275                 280                 285             
Val Arg Val Thr Ala Arg Asp Gly Arg Glu Phe Ala Ala Lys Arg Leu 
    290                 295                 300                 
Val Cys Thr Ile Pro Leu Asn Val Leu Ser Ser Val Gln Phe Ser Pro 
305                 310                 315                 320 
Pro Leu Ser Pro Gln Arg Met Ala Ala Ala Asn Ile Gly His Val Asn 
                325                 330                 335     
Gln Cys Val Lys Val His Ala Glu Val Ser Cys Pro Asp Met Arg Ser 
            340                 345                 350         
Trp Ser Gly Val Ser Tyr Pro Phe Asn Lys Leu Ala Tyr Ala Ile Gly 
        355                 360                 365             
Asp Gly Thr Thr Pro Ala Gly Asn Thr His Ile Val Cys Phe Gly Gly 
    370                 375                 380                 
Ala His Asn His Ile Gln Pro Glu Glu Asp Val Glu Ala Thr Lys Met 
385                 390                 395                 400 
Ala Val Glu Asn Met Ser Pro Gly Asn Met Asp Ile Lys Arg Leu Val 
                405                 410                 415     
Phe His Asn Trp Cys Lys Asp Glu Phe Ala Lys Gly Ala Trp Phe Phe 
            420                 425                 430         
Ala Pro Pro Gln Leu Leu Ser Lys Ser Leu Asp Glu Leu Arg Cys Arg 
        435                 440                 445             
His Gly Asn Val Leu Phe Ala Asn Ser Asp Trp Ala Leu Gly Trp Arg 
    450                 455                 460                 
Gly Phe Ile Asp Gly Ala Ile Glu Glu Gly Thr Arg Ala Ala Val Thr 
465                 470                 475                 480 
Val Ile Glu Glu Leu Arg Pro Ala Pro Ala Val Arg Ser His Leu     
                485                 490                 495     



