                         SEQUENCE LISTING

<110>  DiabetOmics, LLC
       Nagalla, Srinivasa R
       Roberts, Charles T 
       Paturi, Vishnupriya Rao
 
<120>  METHODS FOR DETECTING PRE-DIABETES AND DIABETES

<130>  7301-80676-02

<150>  US 61/083,096
<151>  2008-07-23

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  2
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     


<210>  3
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 
1               5                   10                  15      


Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 
            20                  25                  30          


Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 
        35                  40                  45              


Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 
    50                  55                  60                  


Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 
65                  70                  75                  80  


Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 
                85                  90                  95      


Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 
            100                 105                 110         


Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 
        115                 120                 125             


Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 
    130                 135                 140                 


Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 
145                 150                 155                 160 


Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 
                165                 170                 175     


Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 
            180                 185                 190         


Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln 
        195                 200                 205             


Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser 
    210                 215                 220                 


Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln 
225                 230                 235                 240 


Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe 
                245                 250                 255     


Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val 
            260                 265                 270         


Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 
        275                 280                 285             


Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
    290                 295                 300                 


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
305                 310                 315                 320 


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
            340                 345                 350         


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
        355                 360                 365             


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
    370                 375                 380                 


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
385                 390                 395                 400 


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
                405                 410                 415     


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
            420                 425                 430         


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
        435                 440                 445             


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
    450                 455                 460                 


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
465                 470                 475                 480 


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
                485                 490                 495     


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
            500                 505                 510         


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
        515                 520                 525             


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
    530                 535                 540                 


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
545                 550                 555                 560 


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
                565                 570                 575     


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
            580                 585                 590         


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
        595                 600                 605             


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
    610                 615                 620                 


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
625                 630                 635                 640 


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
                645                 650                 655     


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
            660                 665                 670         


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
        675                 680                 685             


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
    690                 695                 700                 


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
705                 710                 715                 720 


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
                725                 730                 735     


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
            740                 745                 750         


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
        755                 760                 765             


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
    770                 775                 780                 


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
785                 790                 795                 800 


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
                805                 810                 815     


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
            820                 825                 830         


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
        835                 840                 845             


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
    850                 855                 860                 


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
865                 870                 875                 880 


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
                885                 890                 895     


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
            900                 905                 910     


<210>  4
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Asn Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe 
    610                 615                 620                 


Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Glu Ala Ser 
625                 630                 635                 640 


Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser 
                645                 650                 655     


Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Leu Leu Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 
        675                 680                 685             


Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro 
    690                 695                 700                 


Asp Pro Ala Val Ser Arg Val Met Asn Ile Lys Ile Glu Glu Thr Thr 
705                 710                 715                 720 


Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu 
                725                 730                 735     


Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His 
            740                 745                 750         


Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu 
        755                 760                 765             


Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu 
    770                 775                 780                 


Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His 
785                 790                 795                 800 


Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu 
                805                 810                 815     


Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr 
            820                 825                 830         


Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu 
        835                 840                 845             


Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr 
    850                 855                 860                 


Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln 
865                 870                 875                 880 


Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr 
                885                 890                 895     


Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu 
            900                 905                 910         


Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val 
        915                 920                 925             


Glu Leu 
    930 


<210>  5
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 
                325                 330                 335     


Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 
            340                 345                 350         


Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 
        355                 360                 365             


Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 
    370                 375                 380                 


Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 
385                 390                 395                 400 


Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 
                405                 410                 415     


Glu Pro His Ile 
            420 


<210>  6
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 
            100                 105                 110         


Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg 
305                 310                 315                 320 


Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser 
    370                 375                 380                 


Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln 
                405                 410                 415     


Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu 
            420                 425                 430         


Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys 
        435                 440                 445             


Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys 
    450                 455                 460                 


Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln 
465                 470                 475                 480 


Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala 
                485                 490                 495     


Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala 
            500                 505                 510         


Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu 
        515                 520                 525             


Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile 
    530                 535                 540                 


His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg 
545                 550                 555                 560 


Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser 
                565                 570                 575     


Met 
    


<210>  7
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  8
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  9
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210>  10
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Arg Arg Asp Asp Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Thr Asn Tyr Leu Ala Asp Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Thr Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210>  11
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly 
1               5                   10                  15      


Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn 
            20                  25                  30          


Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys 
        35                  40                  45              


Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu 
    50                  55                  60                  


Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro 
65                  70                  75                  80  


Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu 
                85                  90                  95      


Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala 
            100                 105                 110         


Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu 
        115                 120                 125             


Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro 
    130                 135                 140                 


Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val 
145                 150                 155                 160 


Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met 
                165                 170                 175     


Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys 
            180                 185                 190         


Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe 
        195                 200                 205             


Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile 
    210                 215                 220                 


Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met 
225                 230                 235                 240 


Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser 
                245                 250                 255     


Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys 
            260                 265                 270         


Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr 
        275                 280                 285             


Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala 
    290                 295                 300                 


Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser 
305                 310                 315                 320 


Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp 
                325                 330                 335     


Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr 
            340                 345                 350         


Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile 
        355                 360                 365             


Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn 
    370                 375                 380                 


Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu 
385                 390                 395                 400 


Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn 
                405                 410                 415     


Ile 
    


<210>  12
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  13
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Lys Cys Lys Gln Val Glu Glu Glu Leu Thr His Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Asp Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Thr Glu Lys Lys Ala Ser Asp 
65                  70                  75                  80  


Ala Glu Gly Asp Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Val Ser Glu Leu Lys Cys Gly Asp 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Ala Ser Glu Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Leu Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Leu Ala Gln Ala Lys Glu Glu Asn Val Gly Leu His Gln 
            260                 265                 270         


Thr Leu Asp Gln Thr Leu Asn Glu Leu Asn Cys Ile 
        275                 280                 


<210>  14
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Ala Pro His Leu His Leu Ser Ala Ala Ser Gly Ala Arg Ala 
1               5                   10                  15      


Leu Ala Lys Leu Leu Pro Leu Leu Met Ala Gln Leu Trp Ala Ala Glu 
            20                  25                  30          


Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu Asp Pro Glu Ala Tyr 
        35                  40                  45              


Gly Ala Pro Cys Ala Arg Gly Ser Gln Pro Trp Gln Val Ser Leu Phe 
    50                  55                  60                  


Asn Gly Leu Ser Phe His Cys Ala Gly Val Leu Val Asp Gln Ser Trp 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Gly Asn Lys Pro Leu Trp Ala Arg Val 
                85                  90                  95      


Gly Asp Asp His Leu Leu Leu Leu Gln Gly Glu Gln Leu Arg Arg Thr 
            100                 105                 110         


Thr Arg Ser Val Val His Pro Lys Tyr His Gln Gly Ser Gly Pro Ile 
        115                 120                 125             


Leu Pro Arg Arg Thr Asp Glu His Asp Leu Met Leu Leu Lys Leu Ala 
    130                 135                 140                 


Arg Pro Val Val Pro Gly Pro Arg Val Arg Ala Leu Gln Leu Pro Tyr 
145                 150                 155                 160 


Arg Cys Ala Gln Pro Gly Asp Gln Cys Gln Val Ala Gly Trp Gly Thr 
                165                 170                 175     


Thr Ala Ala Arg Arg Val Lys Tyr Asn Lys Gly Leu Thr Cys Ser Ser 
            180                 185                 190         


Ile Thr Ile Leu Ser Pro Lys Glu Cys Glu Val Phe Tyr Pro Gly Val 
        195                 200                 205             


Val Thr Asn Asn Met Ile Cys Ala Gly Leu Asp Arg Gly Gln Asp Pro 
    210                 215                 220                 


Cys Gln Ser Asp Ser Gly Gly Pro Leu Val Cys Asp Glu Thr Leu Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Trp Gly Val Tyr Pro Cys Gly Ser Ala Gln His Pro 
                245                 250                 255     


Ala Val Tyr Thr Gln Ile Cys Lys Tyr Met Ser Trp Ile Asn Lys Val 
            260                 265                 270         


Ile Arg Ser Asn 
        275     


<210>  15
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Val  Arg Asn His Tyr Asn  Glu Glu Met 
    1190                 1195                 1200             


Ser Asn  Leu Arg Asn Lys Tyr  Glu Thr Glu Ile Asn  Ile Thr Lys 
    1205                 1210                 1215             


Thr Thr  Ile Lys Glu Ile Ser  Met Gln Lys Glu Asp  Asp Ser Lys 
    1220                 1225                 1230             


Asn Leu  Arg Asn Gln Leu Asp  Arg Leu Ser Arg Glu  Asn Arg Asp 
    1235                 1240                 1245             


Leu Lys  Asp Glu Ile Val Arg  Leu Asn Asp Ser Ile  Leu Gln Ala 
    1250                 1255                 1260             


Thr Glu  Gln Arg Arg Arg Ala  Glu Glu Asn Ala Leu  Gln Gln Lys 
    1265                 1270                 1275             


Ala Cys  Gly Ser Glu Ile Met  Gln Lys Lys Gln His  Leu Glu Ile 
    1280                 1285                 1290             


Glu Leu  Lys Gln Val Met Gln  Gln Arg Ser Glu Asp  Asn Ala Arg 
    1295                 1300                 1305             


His Lys  Gln Ser Leu Glu Glu  Ala Ala Lys Thr Ile  Gln Asp Lys 
    1310                 1315                 1320             


Asn Lys  Glu Ile Glu Arg Leu  Lys Ala Glu Phe Gln  Glu Glu Ala 
    1325                 1330                 1335             


Lys Arg  Arg Trp Glu Tyr Glu  Asn Glu Leu Ser Lys  Val Arg Asn 
    1340                 1345                 1350             


Asn Tyr  Asp Glu Glu Ile Ile  Ser Leu Lys Asn Gln  Phe Glu Thr 
    1355                 1360                 1365             


Glu Ile  Asn Ile Thr Lys Thr  Thr Ile His Gln Leu  Thr Met Gln 
    1370                 1375                 1380             


Lys Glu  Glu Asp Thr Ser Gly  Tyr Arg Ala Gln Ile  Asp Asn Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asn Arg Ser Leu  Ser Glu Glu Ile Lys  Arg Leu Lys 
    1400                 1405                 1410             


Asn Thr  Leu Thr Gln Thr Thr  Glu Asn Leu Arg Arg  Val Glu Glu 
    1415                 1420                 1425             


Asp Ile  Gln Gln Gln Lys Ala  Thr Gly Ser Glu Val  Ser Gln Arg 
    1430                 1435                 1440             


Lys Gln  Gln Leu Glu Val Glu  Leu Arg Gln Val Thr  Gln Met Arg 
    1445                 1450                 1455             


Thr Glu  Glu Ser Val Arg Tyr  Lys Gln Ser Leu Asp  Asp Ala Ala 
    1460                 1465                 1470             


Lys Thr  Ile Gln Asp Lys Asn  Lys Glu Ile Glu Arg  Leu Lys Gln 
    1475                 1480                 1485             


Leu Ile  Asp Lys Glu Thr Asn  Asp Arg Lys Cys Leu  Glu Asp Glu 
    1490                 1495                 1500             


Asn Ala  Arg Leu Gln Arg Val  Gln Tyr Asp Leu Gln  Lys Ala Asn 
    1505                 1510                 1515             


Ser Ser  Ala Thr Glu Thr Ile  Asn Lys Leu Lys Val  Gln Glu Gln 
    1520                 1525                 1530             


Glu Leu  Thr Arg Leu Arg Ile  Asp Tyr Glu Arg Val  Ser Gln Glu 
    1535                 1540                 1545             


Arg Thr  Val Lys Asp Gln Asp  Ile Thr Arg Phe Gln  Asn Ser Leu 
    1550                 1555                 1560             


Lys Glu  Leu Gln Leu Gln Lys  Gln Lys Val Glu Glu  Glu Leu Asn 
    1565                 1570                 1575             


Arg Leu  Lys Arg Thr Ala Ser  Glu Asp Ser Cys Lys  Arg Lys Lys 
    1580                 1585                 1590             


Leu Glu  Glu Glu Leu Glu Gly  Met Arg Arg Ser Leu  Lys Glu Gln 
    1595                 1600                 1605             


Ala Ile  Lys Ile Thr Asn Leu  Thr Gln Gln Leu Glu  Gln Ala Ser 
    1610                 1615                 1620             


Ile Val  Lys Lys Arg Ser Glu  Asp Asp Leu Arg Gln  Gln Arg Asp 
    1625                 1630                 1635             


Val Leu  Asp Gly His Leu Arg  Glu Lys Gln Arg Thr  Gln Glu Glu 
    1640                 1645                 1650             


Leu Arg  Arg Leu Ser Ser Glu  Val Glu Ala Leu Arg  Arg Gln Leu 
    1655                 1660                 1665             


Leu Gln  Glu Gln Glu Ser Val  Lys Gln Ala His Leu  Arg Asn Glu 
    1670                 1675                 1680             


His Phe  Gln Lys Ala Ile Glu  Asp Lys Ser Arg Ser  Leu Asn Glu 
    1685                 1690                 1695             


Ser Lys  Ile Glu Ile Glu Arg  Leu Gln Ser Leu Thr  Glu Asn Leu 
    1700                 1705                 1710             


Thr Lys  Glu His Leu Met Leu  Glu Glu Glu Leu Arg  Asn Leu Arg 
    1715                 1720                 1725             


Leu Glu  Tyr Asp Asp Leu Arg  Arg Gly Arg Ser Glu  Ala Asp Ser 
    1730                 1735                 1740             


Asp Lys  Asn Ala Thr Ile Leu  Glu Leu Arg Ser Gln  Leu Gln Ile 
    1745                 1750                 1755             


Ser Asn  Asn Arg Thr Leu Glu  Leu Gln Gly Leu Ile  Asn Asp Leu 
    1760                 1765                 1770             


Gln Arg  Glu Arg Glu Asn Leu  Arg Gln Glu Ile Glu  Lys Phe Gln 
    1775                 1780                 1785             


Lys Gln  Ala Leu Glu Ala Ser  Asn Arg Ile Gln Glu  Ser Lys Asn 
    1790                 1795                 1800             


Gln Cys  Thr Gln Val Val Gln  Glu Arg Glu Ser Leu  Leu Val Lys 
    1805                 1810                 1815             


Ile Lys  Val Leu Glu Gln Asp  Lys Ala Arg Leu Gln  Arg Leu Glu 
    1820                 1825                 1830             


Asp Glu  Leu Asn Arg Ala Lys  Ser Thr Leu Glu Ala  Glu Thr Arg 
    1835                 1840                 1845             


Val Lys  Gln Arg Leu Glu Cys  Glu Lys Gln Gln Ile  Gln Asn Asp 
    1850                 1855                 1860             


Leu Asn  Gln Trp Lys Thr Gln  Tyr Ser Arg Lys Glu  Glu Ala Ile 
    1865                 1870                 1875             


Arg Lys  Ile Glu Ser Glu Arg  Glu Lys Ser Glu Arg  Glu Lys Asn 
    1880                 1885                 1890             


Ser Leu  Arg Ser Glu Ile Glu  Arg Leu Gln Ala Glu  Ile Lys Arg 
    1895                 1900                 1905             


Ile Glu  Glu Arg Cys Arg Arg  Lys Leu Glu Asp Ser  Thr Arg Glu 
    1910                 1915                 1920             


Thr Gln  Ser Gln Leu Glu Thr  Glu Arg Ser Arg Tyr  Gln Arg Glu 
    1925                 1930                 1935             


Ile Asp  Lys Leu Arg Gln Arg  Pro Tyr Gly Ser His  Arg Glu Thr 
    1940                 1945                 1950             


Gln Thr  Glu Cys Glu Trp Thr  Val Asp Thr Ser Lys  Leu Val Phe 
    1955                 1960                 1965             


Asp Gly  Leu Arg Lys Lys Val  Thr Ala Met Gln Leu  Tyr Glu Cys 
    1970                 1975                 1980             


Gln Leu  Ile Asp Lys Thr Thr  Leu Asp Lys Leu Leu  Lys Gly Lys 
    1985                 1990                 1995             


Lys Ser  Val Glu Glu Val Ala  Ser Glu Ile Gln Pro  Phe Leu Arg 
    2000                 2005                 2010             


Gly Ala  Gly Ser Ile Ala Gly  Ala Ser Ala Ser Pro  Lys Glu Lys 
    2015                 2020                 2025             


Tyr Ser  Leu Val Glu Ala Lys  Arg Lys Lys Leu Ile  Ser Pro Glu 
    2030                 2035                 2040             


Ser Thr  Val Met Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Gly Ile 
    2045                 2050                 2055             


Ile Asp  Pro His Arg Asn Glu  Lys Leu Thr Val Asp  Ser Ala Ile 
    2060                 2065                 2070             


Ala Arg  Asp Leu Ile Asp Phe  Asp Asp Arg Gln Gln  Ile Tyr Ala 
    2075                 2080                 2085             


Ala Glu  Lys Ala Ile Thr Gly  Phe Asp Asp Pro Phe  Ser Gly Lys 
    2090                 2095                 2100             


Thr Val  Ser Val Ser Glu Ala  Ile Lys Lys Asn Leu  Ile Asp Arg 
    2105                 2110                 2115             


Glu Thr  Gly Met Arg Leu Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2120                 2125                 2130             


Val Val  Asp Pro Val Asn Ser  Val Phe Leu Pro Lys  Asp Val Ala 
    2135                 2140                 2145             


Leu Ala  Arg Gly Leu Ile Asp  Arg Asp Leu Tyr Arg  Ser Leu Asn 
    2150                 2155                 2160             


Asp Pro  Arg Asp Ser Gln Lys  Asn Phe Val Asp Pro  Val Thr Lys 
    2165                 2170                 2175             


Lys Lys  Val Ser Tyr Val Gln  Leu Lys Glu Arg Cys  Arg Ile Glu 
    2180                 2185                 2190             


Pro His  Thr Gly Leu Leu Leu  Leu Ser Val Gln Lys  Arg Ser Met 
    2195                 2200                 2205             


Ser Phe  Gln Gly Ile Arg Gln  Pro Val Thr Val Thr  Glu Leu Val 
    2210                 2215                 2220             


Asp Ser  Gly Ile Leu Arg Pro  Ser Thr Val Asn Glu  Leu Glu Ser 
    2225                 2230                 2235             


Gly Gln  Ile Ser Tyr Asp Glu  Val Gly Glu Arg Ile  Lys Asp Phe 
    2240                 2245                 2250             


Leu Gln  Gly Ser Ser Cys Ile  Ala Gly Ile Tyr Asn  Glu Thr Thr 
    2255                 2260                 2265             


Lys Gln  Lys Leu Gly Ile Tyr  Glu Ala Met Lys Ile  Gly Leu Val 
    2270                 2275                 2280             


Arg Pro  Gly Thr Ala Leu Glu  Leu Leu Glu Ala Gln  Ala Ala Thr 
    2285                 2290                 2295             


Gly Phe  Ile Val Asp Pro Val  Ser Asn Leu Arg Leu  Pro Val Glu 
    2300                 2305                 2310             


Glu Ala  Tyr Lys Arg Gly Leu  Val Gly Ile Glu Phe  Lys Glu Lys 
    2315                 2320                 2325             


Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly Tyr Asn  Asp Pro Glu 
    2330                 2335                 2340             


Thr Gly  Asn Ile Ile Ser Leu  Phe Gln Ala Met Asn  Lys Glu Leu 
    2345                 2350                 2355             


Ile Glu  Lys Gly His Gly Ile  Arg Leu Leu Glu Ala  Gln Ile Ala 
    2360                 2365                 2370             


Thr Gly  Gly Ile Ile Asp Pro  Lys Glu Ser His Arg  Leu Pro Val 
    2375                 2380                 2385             


Asp Ile  Ala Tyr Lys Arg Gly  Tyr Phe Asn Glu Glu  Leu Ser Glu 
    2390                 2395                 2400             


Ile Leu  Ser Asp Pro Ser Asp  Asp Thr Lys Gly Phe  Phe Asp Pro 
    2405                 2410                 2415             


Asn Thr  Glu Glu Asn Leu Thr  Tyr Leu Gln Leu Lys  Glu Arg Cys 
    2420                 2425                 2430             


Ile Lys  Asp Glu Glu Thr Gly  Leu Cys Leu Leu Pro  Leu Lys Glu 
    2435                 2440                 2445             


Lys Lys  Lys Gln Val Gln Thr  Ser Gln Lys Asn Thr  Leu Arg Lys 
    2450                 2455                 2460             


Arg Arg  Val Val Ile Val Asp  Pro Glu Thr Asn Lys  Glu Met Ser 
    2465                 2470                 2475             


Val Gln  Glu Ala Tyr Lys Lys  Gly Leu Ile Asp Tyr  Glu Thr Phe 
    2480                 2485                 2490             


Lys Glu  Leu Cys Glu Gln Glu  Cys Glu Trp Glu Glu  Ile Thr Ile 
    2495                 2500                 2505             


Thr Gly  Ser Asp Gly Ser Thr  Arg Val Val Leu Val  Asp Arg Lys 
    2510                 2515                 2520             


Thr Gly  Ser Gln Tyr Asp Ile  Gln Asp Ala Ile Asp  Lys Gly Leu 
    2525                 2530                 2535             


Val Asp  Arg Lys Phe Phe Asp  Gln Tyr Arg Ser Gly  Ser Leu Ser 
    2540                 2545                 2550             


Leu Thr  Gln Phe Ala Asp Met  Ile Ser Leu Lys Asn  Gly Val Gly 
    2555                 2560                 2565             


Thr Ser  Ser Ser Met Gly Ser  Gly Val Ser Asp Asp  Val Phe Ser 
    2570                 2575                 2580             


Ser Ser  Arg His Glu Ser Val  Ser Lys Ile Ser Thr  Ile Ser Ser 
    2585                 2590                 2595             


Val Arg  Asn Leu Thr Ile Arg  Ser Ser Ser Phe Ser  Asp Thr Leu 
    2600                 2605                 2610             


Glu Glu  Ser Ser Pro Ile Ala  Ala Ile Phe Asp Thr  Glu Asn Leu 
    2615                 2620                 2625             


Glu Lys  Ile Ser Ile Thr Glu  Gly Ile Glu Arg Gly  Ile Val Asp 
    2630                 2635                 2640             


Ser Ile  Thr Gly Gln Arg Leu  Leu Glu Ala Gln Ala  Cys Thr Gly 
    2645                 2650                 2655             


Gly Ile  Ile His Pro Thr Thr  Gly Gln Lys Leu Ser  Leu Gln Asp 
    2660                 2665                 2670             


Ala Val  Ser Gln Gly Val Ile  Asp Gln Asp Met Ala  Thr Arg Leu 
    2675                 2680                 2685             


Lys Pro  Ala Gln Lys Ala Phe  Ile Gly Phe Glu Gly  Val Lys Gly 
    2690                 2695                 2700             


Lys Lys  Lys Met Ser Ala Ala  Glu Ala Val Lys Glu  Lys Trp Leu 
    2705                 2710                 2715             


Pro Tyr  Glu Ala Gly Gln Arg  Phe Leu Glu Phe Gln  Tyr Leu Thr 
    2720                 2725                 2730             


Gly Gly  Leu Val Asp Pro Glu  Val His Gly Arg Ile  Ser Thr Glu 
    2735                 2740                 2745             


Glu Ala  Ile Arg Lys Gly Phe  Ile Asp Gly Arg Ala  Ala Gln Arg 
    2750                 2755                 2760             


Leu Gln  Asp Thr Ser Ser Tyr  Ala Lys Ile Leu Thr  Cys Pro Lys 
    2765                 2770                 2775             


Thr Lys  Leu Lys Ile Ser Tyr  Lys Asp Ala Ile Asn  Arg Ser Met 
    2780                 2785                 2790             


Val Glu  Asp Ile Thr Gly Leu  Arg Leu Leu Glu Ala  Ala Ser Val 
    2795                 2800                 2805             


Ser Ser  Lys Gly Leu Pro Ser  Pro Tyr Asn Met Ser  Ser Ala Pro 
    2810                 2815                 2820             


Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser Arg Ser  Gly Ser Arg 
    2825                 2830                 2835             


Ser Gly  Ser Arg Ser Gly Ser  Arg Arg Gly Ser Phe  Asp Ala Thr 
    2840                 2845                 2850             


Gly Asn  Ser Ser Tyr Ser Tyr  Ser Tyr Ser Phe Ser  Ser Ser Ser 
    2855                 2860                 2865             


Ile Gly  His 
    2870     


<210>  16
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala 
            100                 105                 110         


Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val 
        115                 120                 125             


Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu 
    130                 135                 140                 


Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr 
145                 150                 155                 160 


Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile 
                165                 170                 175     


Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp 
            180                 185                 190         


Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln 
        195                 200                 205     


<210>  17
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln 
1               5                   10                  15      


Val Pro Gly Met Gln Met Gly Gln Pro Val Pro Glu Thr Gly Pro Ala 
            20                  25                  30          


Ile Leu Leu Asp Gly Tyr Ser Gly Pro Ala Tyr Ser Asp Thr Tyr Ser 
        35                  40                  45              


Ser Ala Gly Asp Ser Val Tyr Thr Tyr Phe Ser Ala Val Ala Gly Gln 
    50                  55                  60                  


Asp Gly Glu Val Asp Ala Glu Glu Leu Gln Arg Cys Leu Thr Gln Ser 
65                  70                  75                  80  


Gly Ile Asn Gly Thr Tyr Ser Pro Phe Ser Leu Glu Thr Cys Arg Ile 
                85                  90                  95      


Met Ile Ala Met Leu Asp Arg Asp His Thr Gly Lys Met Gly Phe Asn 
            100                 105                 110         


Ala Phe Lys Glu Leu Trp Ala Ala Leu Asn Ala Trp Lys Glu Asn Phe 
        115                 120                 125             


Met Thr Val Asp Gln Asp Gly Ser Gly Thr Val Glu His His Glu Leu 
    130                 135                 140                 


Arg Gln Ala Ile Gly Leu Met Gly Tyr Arg Leu Ser Pro Gln Thr Leu 
145                 150                 155                 160 


Thr Thr Ile Val Lys Arg Tyr Ser Lys Asn Gly Arg Ile Phe Phe Asp 
                165                 170                 175     


Asp Tyr Val Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Phe Phe 
            180                 185                 190         


Arg Lys Arg Asp His Leu Gln Gln Gly Ser Ala Asn Phe Ile Tyr Asp 
        195                 200                 205             


Asp Phe Leu Gln Gly Thr Met Ala Ile 
    210                 215         


<210>  18
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  19
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Leu Ala Val Thr Leu Thr Leu Val Thr Leu Ala Leu Cys Cys 
1               5                   10                  15      


Ser Ser Ala Ser Ala Glu Ile Cys Pro Ser Phe Gln Arg Val Ile Glu 
            20                  25                  30          


Thr Leu Leu Met Asp Thr Pro Ser Ser Tyr Glu Ala Ala Met Glu Leu 
        35                  40                  45              


Phe Ser Pro Asp Gln Asp Met Arg Glu Ala Gly Ala Gln Leu Lys Lys 
    50                  55                  60                  


Leu Val Asp Thr Leu Pro Gln Lys Pro Arg Glu Ser Ile Ile Lys Leu 
65                  70                  75                  80  


Met Glu Lys Ile Ala Gln Ser Ser Leu Cys Asn 
                85                  90      


<210>  20
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu Leu Gly Gly Gln 
1               5                   10                  15      


Ala Gln His Val Ser Asp Trp Thr Tyr Ser Glu Gly Ala Leu Asp Glu 
            20                  25                  30          


Ala His Trp Pro Gln His Tyr Pro Ala Cys Gly Gly Gln Arg Gln Ser 
        35                  40                  45              


Pro Ile Asn Leu Gln Arg Thr Lys Val Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Leu Asn Met Thr Gly Tyr Glu Thr Gln Ala Gly Glu Phe Pro Met 
65                  70                  75                  80  


Val Asn Asn Gly His Thr Val Gln Ile Ser Leu Pro Ser Thr Met Arg 
                85                  90                  95      


Met Thr Val Ala Asp Gly Thr Val Tyr Ile Ala Gln Gln Met His Phe 
            100                 105                 110         


His Trp Gly Gly Ala Ser Ser Glu Ile Ser Gly Ser Glu His Thr Val 
        115                 120                 125             


Asp Gly Ile Arg His Val Ile Glu Ile His Ile Val His Tyr Asn Ser 
    130                 135                 140                 


Lys Tyr Lys Ser Tyr Asp Ile Ala Gln Asp Ala Pro Asp Gly Leu Ala 
145                 150                 155                 160 


Val Leu Ala Ala Phe Val Glu Val Lys Asn Tyr Pro Glu Asn Thr Tyr 
                165                 170                 175     


Tyr Ser Asn Phe Ile Ser His Leu Ala Asn Ile Lys Tyr Pro Gly Gln 
            180                 185                 190         


Arg Thr Thr Leu Thr Gly Leu Asp Val Gln Asp Met Leu Pro Arg Asn 
        195                 200                 205             


Leu Gln His Tyr Tyr Thr Tyr His Gly Ser Leu Thr Thr Pro Pro Cys 
    210                 215                 220                 


Thr Glu Asn Val His Trp Phe Val Leu Ala Asp Phe Val Lys Leu Ser 
225                 230                 235                 240 


Arg Thr Gln Val Trp Lys Leu Glu Asn Ser Leu Leu Asp His Arg Asn 
                245                 250                 255     


Lys Thr Ile His Asn Asp Tyr Arg Arg Thr Gln Pro Leu Asn His Arg 
            260                 265                 270         


Val Val Glu Ser Asn Phe Pro Asn Gln Glu Tyr Thr Leu Gly Ser Glu 
        275                 280                 285             


Phe Gln Phe Tyr Leu His Lys Ile Glu Glu Ile Leu Asp Tyr Leu Arg 
    290                 295                 300                 


Arg Ala Leu Asn 
305             


<210>  21
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  22
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  23
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr 
        35                  40                  45              


Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys 
    50                  55                  60                  


Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser 
                85                  90                  95      


Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            100                 105                 110         


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        115                 120                 125             


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    130                 135                 140                 


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
145                 150                 155                 160 


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                165                 170                 175     


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            180                 185                 190         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        195                 200                 205             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
225                 230                 235                 240 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                245                 250                 255     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly 
            260                 265                 270         


Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp 
    290                 295                 300                 


Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe 
                325                 330                 335     


Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu 
            340                 345                 350         


Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr 
        355                 360                 365             


Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg 
    370                 375                 380                 


Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn 
385                 390                 395                 400 


Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala 
                405                 410                 415     


Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His 
            420                 425                 430         


Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile 
        435                 440                 445             


Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys 
    450                 455                 460                 


Arg Tyr Gly 
465         


<210>  24
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Val  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210>  25
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  26
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210>  27
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Lys Ile Ser Glu Ala Val Lys Arg Ala Arg Ala Ala Phe Ser 
1               5                   10                  15      


Ser Gly Arg Thr Arg Pro Leu Gln Phe Arg Ile Gln Gln Leu Glu Ala 
            20                  25                  30          


Leu Gln Arg Leu Ile Gln Glu Gln Glu Gln Glu Leu Val Gly Ala Leu 
        35                  40                  45              


Ala Ala Asp Leu His Lys Asn Glu Trp Asn Ala Tyr Tyr Glu Glu Val 
    50                  55                  60                  


Val Tyr Val Leu Glu Glu Ile Glu Tyr Met Ile Gln Lys Leu Pro Glu 
65                  70                  75                  80  


Trp Ala Ala Asp Glu Pro Val Glu Lys Thr Pro Gln Thr Gln Gln Asp 
                85                  90                  95      


Glu Leu Tyr Ile His Ser Glu Pro Leu Gly Val Val Leu Val Ile Gly 
            100                 105                 110         


Thr Trp Asn Tyr Pro Phe Asn Leu Thr Ile Gln Pro Met Val Gly Ala 
        115                 120                 125             


Ile Ala Ala Gly Asn Ala Val Val Leu Lys Pro Ser Glu Leu Ser Glu 
    130                 135                 140                 


Asn Met Ala Ser Leu Leu Ala Thr Ile Ile Pro Gln Tyr Leu Asp Lys 
145                 150                 155                 160 


Asp Leu Tyr Pro Val Ile Asn Gly Gly Val Pro Glu Thr Thr Glu Leu 
                165                 170                 175     


Leu Lys Glu Arg Phe Asp His Ile Leu Tyr Thr Gly Ser Thr Gly Val 
            180                 185                 190         


Gly Lys Ile Ile Met Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr 
        195                 200                 205             


Leu Glu Leu Gly Gly Lys Ser Pro Cys Tyr Val Asp Lys Asn Cys Asp 
    210                 215                 220                 


Leu Asp Val Ala Cys Arg Arg Ile Ala Trp Gly Lys Phe Met Asn Ser 
225                 230                 235                 240 


Gly Gln Thr Cys Val Ala Pro Asp Tyr Ile Leu Cys Asp Pro Ser Ile 
                245                 250                 255     


Gln Asn Gln Ile Val Glu Lys Leu Lys Lys Ser Leu Lys Glu Phe Tyr 
            260                 265                 270         


Gly Glu Asp Ala Lys Lys Ser Arg Asp Tyr Gly Arg Ile Ile Ser Ala 
        275                 280                 285             


Arg His Phe Gln Arg Val Met Gly Leu Ile Glu Gly Gln Lys Val Ala 
    290                 295                 300                 


Tyr Gly Gly Thr Gly Asp Ala Ala Thr Arg Tyr Ile Ala Pro Thr Ile 
305                 310                 315                 320 


Leu Thr Asp Val Asp Pro Gln Ser Pro Val Met Gln Glu Glu Ile Phe 
                325                 330                 335     


Gly Pro Val Leu Pro Ile Val Cys Val Arg Ser Leu Glu Glu Ala Ile 
            340                 345                 350         


Gln Phe Ile Asn Gln Arg Glu Lys Pro Leu Ala Leu Tyr Met Phe Ser 
        355                 360                 365             


Ser Asn Asp Lys Val Ile Lys Lys Met Ile Ala Glu Thr Ser Ser Gly 
    370                 375                 380                 


Gly Val Ala Ala Asn Asp Val Ile Val His Ile Thr Leu His Ser Leu 
385                 390                 395                 400 


Pro Phe Gly Gly Val Gly Asn Ser Gly Met Gly Ser Tyr His Gly Lys 
                405                 410                 415     


Lys Ser Phe Glu Thr Phe Ser His Arg Arg Ser Cys Leu Val Arg Pro 
            420                 425                 430         


Leu Met Asn Asp Glu Gly Leu Lys Val Arg Tyr Pro Pro Ser Pro Ala 
        435                 440                 445             


Lys Met Thr Gln His 
    450             


<210>  28
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Thr Val Gln Gln Leu Glu Gly Arg Trp Arg Leu Val Asp Ser 
1               5                   10                  15      


Lys Gly Phe Asp Glu Tyr Met Lys Glu Leu Gly Val Gly Ile Ala Leu 
            20                  25                  30          


Arg Lys Met Gly Ala Met Ala Lys Pro Asp Cys Ile Ile Thr Cys Asp 
        35                  40                  45              


Gly Lys Asn Leu Thr Ile Lys Thr Glu Ser Thr Leu Lys Thr Thr Gln 
    50                  55                  60                  


Phe Ser Cys Thr Leu Gly Glu Lys Phe Glu Glu Thr Thr Ala Asp Gly 
65                  70                  75                  80  


Arg Lys Thr Gln Thr Val Cys Asn Phe Thr Asp Gly Ala Leu Val Gln 
                85                  90                  95      


His Gln Glu Trp Asp Gly Lys Glu Ser Thr Ile Thr Arg Lys Leu Lys 
            100                 105                 110         


Asp Gly Lys Leu Val Val Glu Cys Val Met Asn Asn Val Thr Cys Thr 
        115                 120                 125             


Arg Ile Tyr Glu Lys Val Glu 
    130                 135 


<210>  29
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  30
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gln Pro Leu Leu Cys Leu Gly Asn Leu Glu Asp Ala Arg Glu Arg 
1               5                   10                  15      


Thr Gly Thr Leu Leu Ala Gln His Pro Ala Trp Gly Arg Thr Arg Ala 
            20                  25                  30          


Lys Pro Gly Ser Pro Leu Asn Thr Lys Lys Glu Gly Asp Leu Ile Ala 
        35                  40                  45              


Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys Glu 
    50                  55                  60                  


Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly Glu 
65                  70                  75                  80  


Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu Gly 
                85                  90                  95      


Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp Ala 
            100                 105                 110         


Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys Asn 
        115                 120                 125             


Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr Arg 
    130                 135                 140                 


Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg Leu 
145                 150                 155                 160 


Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val Glu 
                165                 170                 175     


Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp Asn 
            180                 185                 190         


Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala His 
        195                 200                 205             


Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala Gln 
    210                 215                 220                 


Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu Arg 
225                 230                 235                 240 


Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg Leu 
                245                 250                 255     


Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met Gln 
            260                 265                 270         


Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala Leu 
        275                 280                 285             


Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu 
    290                 295                 300                 


Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly Arg 
305                 310                 315                 320 


Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr Lys 
                325                 330                 335     


Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln His 
            340                 345                 350         


Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu Gly 
        355                 360                 365             


Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met Gly 
    370                 375                 380                 


Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr Tyr 
385                 390                 395                 400 


Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr Ile 
                405                 410                 415     


Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu Val 
            420                 425                 430         


Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr Ala 
        435                 440                 445             


Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val Arg 
    450                 455                 460                 


Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp Leu 
465                 470                 475                 480 


Leu His His His His Val Ser Gly Ser Arg Arg 
                485                 490     


<210>  31
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Asn Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Glu 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Val Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Thr  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Gln  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


His Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Lys Thr Thr Lys  Ala Glu Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Thr Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Leu Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Phe Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Lys Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Asn 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  32
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  33
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ser Pro Asp Trp Gly Tyr Asp Asp Lys Asn Gly Pro Glu Gln 
1               5                   10                  15      


Trp Ser Lys Leu Tyr Pro Ile Ala Asn Gly Asn Asn Gln Ser Pro Val 
            20                  25                  30          


Asp Ile Lys Thr Ser Glu Thr Lys His Asp Thr Ser Leu Lys Pro Ile 
        35                  40                  45              


Ser Val Ser Tyr Asn Pro Ala Thr Ala Lys Glu Ile Ile Asn Val Gly 
    50                  55                  60                  


His Ser Phe His Val Asn Phe Glu Asp Asn Asp Asn Arg Ser Val Leu 
65                  70                  75                  80  


Lys Gly Gly Pro Phe Ser Asp Ser Tyr Arg Leu Phe Gln Phe His Phe 
                85                  90                  95      


His Trp Gly Ser Thr Asn Glu His Gly Ser Glu His Thr Val Asp Gly 
            100                 105                 110         


Val Lys Tyr Ser Ala Glu Leu His Val Ala His Trp Asn Ser Ala Lys 
        115                 120                 125             


Tyr Ser Ser Leu Ala Glu Ala Ala Ser Lys Ala Asp Gly Leu Ala Val 
    130                 135                 140                 


Ile Gly Val Leu Met Lys Val Gly Glu Ala Asn Pro Lys Leu Gln Lys 
145                 150                 155                 160 


Val Leu Asp Ala Leu Gln Ala Ile Lys Thr Lys Gly Lys Arg Ala Pro 
                165                 170                 175     


Phe Thr Asn Phe Asp Pro Ser Thr Leu Leu Pro Ser Ser Leu Asp Phe 
            180                 185                 190         


Trp Thr Tyr Pro Gly Ser Leu Thr His Pro Pro Leu Tyr Glu Ser Val 
        195                 200                 205             


Thr Trp Ile Ile Cys Lys Glu Ser Ile Ser Val Ser Ser Glu Gln Leu 
    210                 215                 220                 


Ala Gln Phe Arg Ser Leu Leu Ser Asn Val Glu Gly Asp Asn Ala Val 
225                 230                 235                 240 


Pro Met Gln His Asn Asn Arg Pro Thr Gln Pro Leu Lys Gly Arg Thr 
                245                 250                 255     


Val Arg Ala Ser Phe 
            260     


<210>  34
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  35
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Gln Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asp Gln Cys Ile Tyr Asn Thr Thr Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Ile Ser Arg Tyr Val Gly Gly 
            100                 105                 110         


Gln Glu His Phe Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr 
        115                 120                 125             


Met Leu Ala Phe Asp Val Asn Asp Glu Lys Asn Trp Gly Leu Ser Val 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Arg Ile Pro Lys Ser Asp Val Val Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  36
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  37
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe 
1               5                   10                  15      


Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg 
            20                  25                  30          


Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr 
    50                  55                  60                  


Glu Gly Met Val Val Ala Asp Lys Asn Arg Ser Lys Ile His Phe Ile 
65                  70                  75                  80  


Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp 
                85                  90                  95      


Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser 
            100                 105                 110         


Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln 
        115                 120                 125             


Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly 
    130                 135                 140                 


Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly 
145                 150                 155                 160 


Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala 
                165                 170                 175     


Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu 
            180                 185                 190         


Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn 
        195                 200                 205             


Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn 
    210                 215                 220                 


Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr 
225                 230                 235                 240 


Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr 
                245                 250                 255     


Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln 
            260                 265                 270         


Thr Met Asp Thr Ser 
        275         


<210>  38
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 
                85                  90                  95      


Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 
        115                 120                 125             


Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 
    290                 295                 300                 


Ser His Leu Glu Asp Tyr Pro Phe Asp Ala Glu Tyr 
305                 310                 315     


<210>  39
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr 
            20                  25                  30          


Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser 
        35                  40                  45              


Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys 
    50                  55                  60                  


Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr 
65                  70                  75                  80  


Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala 
                85                  90                  95      


Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala 
            100                 105                 110         


Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn 
        115                 120                 125             


Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala 
    130                 135                 140                 


His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys 
145                 150                 155                 160 


Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe 
                165                 170                 175     


Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp 
            180                 185                 190         


Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala 
        195                 200                 205             


Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn 
    210                 215                 220                 


Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn 
225                 230                 235                 240 


His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr 
                245                 250                 255     


Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp 
            260                 265                 270         


Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr 
        275                 280                 285             


Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val 
    290                 295                 300             


<210>  40
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Gly Arg Tyr Pro Leu Ile Gln Thr Leu 
            340                 345                 350         


Arg Gln Glu Leu Ser Leu Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu 
        355                 360                 365             


Glu Val Pro Lys Pro Gly Gln Pro Ser Glu Pro Glu His Gly Pro Ser 
    370                 375                 380                 


Pro Gly Gln Asp Thr Phe Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro 
385                 390                 395                 400 


Asn Pro Arg Glu Arg Ser Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu 
                405                 410                 415     


Phe Gln Gln Ser Cys Pro Thr Gly Leu Val Phe Ser Asn Ser Cys Lys 
            420                 425                 430         


Cys Cys Thr Trp Asn 
        435         


<210>  41
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Tyr Arg Pro Ala Arg Val Thr Ser Thr Ser Arg Phe Leu Asn Pro 
1               5                   10                  15      


Tyr Val Val Cys Phe Ile Val Val Ala Gly Val Val Ile Leu Ala Val 
            20                  25                  30          


Thr Ile Ala Leu Leu Val Tyr Phe Leu Ala Phe Asp Gln Lys Ser Tyr 
        35                  40                  45              


Phe Tyr Arg Ser Ser Phe Gln Leu Leu Asn Val Glu Tyr Asn Ser Gln 
    50                  55                  60                  


Leu Asn Ser Pro Ala Thr Gln Glu Tyr Arg Thr Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Glu Ser Leu Ile Thr Lys Thr Phe Lys Glu Ser Asn Leu Arg Asn Gln 
                85                  90                  95      


Phe Ile Arg Ala His Val Ala Lys Leu Arg Gln Asp Gly Ser Gly Val 
            100                 105                 110         


Arg Ala Asp Val Val Met Lys Phe Gln Phe Thr Arg Asn Asn Asn Gly 
        115                 120                 125             


Ala Ser Met Lys Ser Arg Ile Glu Ser Val Leu Arg Gln Met Leu Asn 
    130                 135                 140                 


Asn Ser Gly Asn Leu Glu Ile Asn Pro Ser Thr Glu Ile Thr Ser Leu 
145                 150                 155                 160 


Thr Asp Gln Ala Ala Ala Asn Trp Leu Ile Asn Glu Cys Gly Ala Gly 
                165                 170                 175     


Pro Asp Leu Ile Thr Leu Ser Glu Gln Arg Ile Leu Gly Gly Thr Glu 
            180                 185                 190         


Ala Glu Glu Gly Ser Trp Pro Trp Gln Val Ser Leu Arg Leu Asn Asn 
        195                 200                 205             


Ala His His Cys Gly Gly Ser Leu Ile Asn Asn Met Trp Ile Leu Thr 
    210                 215                 220                 


Ala Ala His Cys Phe Arg Ser Asn Ser Asn Pro Arg Asp Trp Ile Ala 
225                 230                 235                 240 


Thr Ser Gly Ile Ser Thr Thr Phe Pro Lys Leu Arg Met Arg Val Arg 
                245                 250                 255     


Asn Ile Leu Ile His Asn Asn Tyr Lys Ser Ala Thr His Glu Asn Asp 
            260                 265                 270         


Ile Ala Leu Val Arg Leu Glu Asn Ser Val Thr Phe Thr Lys Asp Ile 
        275                 280                 285             


His Ser Val Cys Leu Pro Ala Ala Thr Gln Asn Ile Pro Pro Gly Ser 
    290                 295                 300                 


Thr Ala Tyr Val Thr Gly Trp Gly Ala Gln Glu Tyr Ala Gly His Thr 
305                 310                 315                 320 


Val Pro Glu Leu Arg Gln Gly Gln Val Arg Ile Ile Ser Asn Asp Val 
                325                 330                 335     


Cys Asn Ala Pro His Ser Tyr Asn Gly Ala Ile Leu Ser Gly Met Leu 
            340                 345                 350         


Cys Ala Gly Val Pro Gln Gly Gly Val Asp Ala Cys Gln Gly Asp Ser 
        355                 360                 365             


Gly Gly Pro Leu Val Gln Glu Asp Ser Arg Arg Leu Trp Phe Ile Val 
    370                 375                 380                 


Gly Ile Val Ser Trp Gly Asp Gln Cys Gly Leu Pro Asp Lys Pro Gly 
385                 390                 395                 400 


Val Tyr Thr Arg Val Thr Ala Tyr Leu Asp Trp Ile Arg Gln Gln Thr 
                405                 410                 415     


Gly Ile 
        


<210>  42
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  43
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Lys Pro Leu Thr Asp Gln Glu Lys Arg Arg Gln Ile Ser Ile 
1               5                   10                  15      


Arg Gly Ile Val Gly Val Glu Asn Val Ala Glu Leu Lys Lys Ser Phe 
            20                  25                  30          


Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
        35                  40                  45              


Thr Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
    50                  55                  60                  


Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Asp Lys Cys Pro 
65                  70                  75                  80  


Lys Arg Val Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                85                  90                  95      


Gln Asn Thr Met Ile Asn Leu Gly Leu Gln Asn Ala Cys Asp Glu Ala 
            100                 105                 110         


Ile Tyr Gln Leu Gly Leu Asp Ile Glu Glu Leu Glu Glu Ile Glu Glu 
        115                 120                 125             


Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
    130                 135                 140                 


Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
145                 150                 155                 160 


Arg Tyr Glu Tyr Gly Ile Phe Asn Gln Lys Ile Arg Asp Gly Trp Gln 
                165                 170                 175     


Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
            180                 185                 190         


Ser Arg Pro Glu Phe Met Leu Pro Val His Phe Tyr Gly Lys Val Glu 
        195                 200                 205             


His Thr Asn Thr Gly Thr Lys Trp Ile Asp Thr Gln Val Val Leu Ala 
    210                 215                 220                 


Leu Pro Tyr Asp Thr Pro Val Pro Gly Tyr Met Asn Asn Thr Val Asn 
225                 230                 235                 240 


Thr Met Arg Leu Trp Ser Ala Arg Ala Pro Asn Asp Phe Asn Leu Arg 
                245                 250                 255     


Asp Phe Asn Val Gly Asp Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu 
            260                 265                 270         


Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
        275                 280                 285             


Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
    290                 295                 300                 


Leu Gln Asp Ile Ile Arg Arg Phe Lys Ala Ser Lys Phe Gly Ser Thr 
305                 310                 315                 320 


Arg Gly Ala Gly Thr Val Phe Asp Ala Phe Pro Asp Gln Val Ala Ile 
                325                 330                 335     


Gln Leu Asn Asp Thr His Pro Ala Leu Ala Ile Pro Glu Leu Met Arg 
            340                 345                 350         


Ile Phe Val Asp Ile Glu Lys Leu Pro Trp Ser Lys Ala Trp Glu Leu 
        355                 360                 365             


Thr Gln Lys Thr Phe Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
    370                 375                 380                 


Leu Glu Arg Trp Pro Val Asp Leu Val Glu Lys Leu Leu Pro Arg His 
385                 390                 395                 400 


Leu Glu Ile Ile Tyr Glu Ile Asn Gln Lys His Leu Asp Arg Ile Val 
                405                 410                 415     


Ala Leu Phe Pro Lys Asp Val Asp Arg Leu Arg Arg Met Ser Leu Ile 
            420                 425                 430         


Glu Glu Glu Gly Ser Lys Arg Ile Asn Met Ala His Leu Cys Ile Val 
        435                 440                 445             


Gly Ser His Ala Val Asn Gly Val Ala Lys Ile His Ser Asp Ile Val 
    450                 455                 460                 


Lys Thr Lys Val Phe Lys Asp Phe Ser Glu Leu Glu Pro Asp Lys Phe 
465                 470                 475                 480 


Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                485                 490                 495     


Asn Pro Gly Leu Ala Glu Leu Ile Ala Glu Lys Ile Gly Glu Asp Tyr 
            500                 505                 510         


Val Lys Asp Leu Ser Gln Leu Thr Lys Leu His Ser Phe Leu Gly Asp 
        515                 520                 525             


Asp Val Phe Leu Arg Glu Leu Ala Lys Val Lys Gln Glu Asn Lys Leu 
    530                 535                 540                 


Lys Phe Ser Gln Phe Leu Glu Thr Glu Tyr Lys Val Lys Ile Asn Pro 
545                 550                 555                 560 


Ser Ser Met Phe Asp Val Gln Val Lys Arg Ile His Glu Tyr Lys Arg 
                565                 570                 575     


Gln Leu Leu Asn Cys Leu His Val Ile Thr Met Tyr Asn Arg Ile Lys 
            580                 585                 590         


Lys Asp Pro Lys Lys Leu Phe Val Pro Arg Thr Val Ile Ile Gly Gly 
        595                 600                 605             


Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Ile 
    610                 615                 620                 


Thr Ser Val Ala Asp Val Val Asn Asn Asp Pro Met Val Gly Ser Lys 
625                 630                 635                 640 


Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                645                 650                 655     


Val Ile Pro Ala Thr Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly Thr 
            660                 665                 670         


Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
        675                 680                 685             


Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
    690                 695                 700                 


Gly Glu Glu Asn Leu Phe Ile Phe Gly Met Arg Ile Asp Asp Val Ala 
705                 710                 715                 720 


Ala Leu Asp Lys Lys Gly Tyr Glu Ala Lys Glu Tyr Tyr Glu Ala Leu 
                725                 730                 735     


Pro Glu Leu Lys Leu Val Ile Asp Gln Ile Asp Asn Gly Phe Phe Ser 
            740                 745                 750         


Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Ile Asn Met Leu Phe Tyr 
        755                 760                 765             


His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Val Lys Cys 
    770                 775                 780                 


Gln Asp Lys Val Ser Gln Leu Tyr Met Asn Pro Lys Ala Trp Asn Thr 
785                 790                 795                 800 


Met Val Leu Lys Asn Ile Ala Ala Ser Gly Lys Phe Ser Ser Asp Arg 
                805                 810                 815     


Thr Ile Lys Glu Tyr Ala Gln Asn Ile Trp Asn Val Glu Pro Ser Asp 
            820                 825                 830         


Leu Lys Ile Ser Leu Ser Asn Glu Ser Asn Lys Val Asn Gly Asn 
        835                 840                 845         


<210>  44
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  45
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe 
1               5                   10                  15      


Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro 
            20                  25                  30          


Phe Ser Ile Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly 
        35                  40                  45              


Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu 
    50                  55                  60                  


Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg 
65                  70                  75                  80  


Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys 
                85                  90                  95      


Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr 
            100                 105                 110         


Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala 
        115                 120                 125             


Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile 
    130                 135                 140                 


Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met 
                165                 170                 175     


Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg 
            180                 185                 190         


Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr 
        195                 200                 205             


Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu 
    210                 215                 220                 


Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His 
                245                 250                 255     


Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser 
            260                 265                 270         


Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu 
        275                 280                 285             


Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu 
    290                 295                 300                 


Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His 
305                 310                 315                 320 


Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala 
                325                 330                 335     


Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe 
            340                 345                 350         


Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly 
        355                 360                 365             


Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro 
    370                 375                 


<210>  46
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  47
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Asp Ser Leu Ala Thr Ser Ile Asn Gln Phe Ala Leu Glu Leu Ser 
1               5                   10                  15      


Lys Lys Leu Ala Glu Ser Ala Gln Gly Lys Asn Ile Phe Phe Ser Ser 
            20                  25                  30          


Trp Ser Ile Ser Thr Ser Leu Thr Met Val Tyr Leu Gly Ala Lys Gly 
        35                  40                  45              


Thr Thr Ala Ala Gln Met Ala Gln Val Leu Gln Phe Asn Arg Asp Gln 
    50                  55                  60                  


Gly Val Lys Cys Asp Pro Glu Ser Glu Lys Lys Arg Lys Met Glu Phe 
65                  70                  75                  80  


Asn Leu Ser Asn Ser Glu Glu Ile His Ser Asp Phe Gln Thr Leu Ile 
                85                  90                  95      


Ser Glu Ile Leu Lys Pro Asn Asp Asp Tyr Leu Leu Lys Thr Ala Asn 
            100                 105                 110         


Ala Ile Tyr Gly Glu Lys Thr Tyr Ala Phe His Asn Lys Tyr Leu Glu 
        115                 120                 125             


Asp Met Lys Thr Tyr Phe Asp Ala Glu Pro Gln Ser Val Asn Phe Val 
    130                 135                 140                 


Glu Ala Ser Asp Gln Ile Arg Lys Asp Ile Asn Ser Trp Val Glu Arg 
145                 150                 155                 160 


Gln Thr Glu Gly Lys Ile Gln Asn Leu Leu Pro Asp Asp Ser Val Asp 
                165                 170                 175     


Ser Thr Thr Arg Met Ile Leu Val Asn Ala Leu Tyr Phe Lys Gly Ile 
            180                 185                 190         


Trp Glu His Gln Phe Leu Val Gln Asn Thr Thr Glu Lys Pro Phe Arg 
        195                 200                 205             


Ile Asn Glu Thr Thr Ser Lys Pro Val Gln Met Met Phe Met Lys Lys 
    210                 215                 220                 


Lys Leu His Ile Phe His Ile Glu Lys Pro Lys Ala Val Gly Leu Gln 
225                 230                 235                 240 


Leu Tyr Tyr Lys Ser Cys Asp Leu Ser Leu Leu Ile Leu Leu Pro Glu 
                245                 250                 255     


Asp Ile Asn Gly Leu Glu Gln Leu Glu Lys Ala Ile Thr Tyr Glu Lys 
            260                 265                 270         


Leu Asn Glu Trp Thr Ser Ala Asp Met Met Glu Leu Tyr Glu Val Gln 
        275                 280                 285             


Leu His Leu Pro Lys Phe Lys Leu Glu Asp Ser Tyr Asp Leu Lys Ser 
    290                 295                 300                 


Thr Leu Ser Ser Met Gly Met Ser Asp Ala Phe Ser Gln Ser Lys Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Met Ser Ser Ala Arg Asn Leu Phe Leu Ser Asn Val 
                325                 330                 335     


Phe His Lys Ala Phe Val Glu Ile Asn Glu Gln Gly Thr Glu Ala Ala 
            340                 345                 350         


Ala Gly Ser Gly Ser Glu Ile Asp Ile Arg Ile Arg Val Pro Ser Ile 
        355                 360                 365             


Glu Phe Asn Ala Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys 
    370                 375                 380                 


Thr Asn Thr Ile Leu Phe Tyr Gly Arg Leu Cys Ser Pro 
385                 390                 395         


<210>  48
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Ala Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Ser Lys Cys Pro Gln Ser Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  49
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Gly Glu Leu Thr Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala 
1               5                   10                  15      


Phe Ser Ala Val Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu 
            20                  25                  30          


Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gln 
        35                  40                  45              


Leu Arg Lys Leu Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile 
    50                  55                  60                  


Ser Phe Gln Glu Phe Leu Thr Ala Ala Arg Lys Ala Arg Ala Gly Leu 
65                  70                  75                  80  


Glu Asp Leu Gln Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly 
                85                  90                  95      


His Ile Thr Val Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln 
            100                 105                 110         


Pro Leu Pro Gln Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val 
        115                 120                 125             


Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala 
    130                 135                 140                 


Gln Glu 
145     


<210>  50
<211>  5890
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210>  51
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu 
1               5                   10                  15      


Lys Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys 
            20                  25                  30          


Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Val Val 
        35                  40                  45              


Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys 
    50                  55                  60                  


Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr 
                85                  90                  95      


Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala 
            100                 105                 110         


Ser Gly Glu Ala Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys Ala 
        115                 120                 125             


Lys Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Ala Thr Gly Ala 
    130                 135                 140                 


Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Pro Ala Ala Ala Ala Gly Ala Lys Lys Ala Lys Ser Pro Lys Lys Ala 
                165                 170                 175     


Lys Ala Ala Lys Pro Lys Lys Ala Pro Lys Ser Pro Ala Lys Ala Lys 
            180                 185                 190         


Ala Val Lys Pro Lys Ala Ala Lys Pro Lys Thr Ala Lys Pro Lys Ala 
        195                 200                 205             


Ala Lys Pro Lys Lys Ala Ala Ala Lys Lys Lys 
    210                 215                 


<210>  52
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 
            20                  25                  30          


Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 
        35                  40                  45              


Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 
    50                  55                  60                  


Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu 
65                  70                  75                  80  


Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 
                85                  90                  95      


Gly Glu Gln Val Arg Glu Val Val His Ser Ile Pro His Pro Glu Tyr 
            100                 105                 110         


Arg Arg Ser Pro Thr His Leu Asn His Asp His Asp Ile Met Leu Leu 
        115                 120                 125             


Glu Leu Gln Ser Pro Val Gln Leu Thr Gly Tyr Ile Gln Thr Leu Pro 
    130                 135                 140                 


Leu Ser His Asn Asn Arg Leu Thr Pro Gly Thr Thr Cys Arg Val Ser 
145                 150                 155                 160 


Gly Trp Gly Thr Thr Thr Ser Pro Gln Val Asn Tyr Pro Lys Thr Leu 
                165                 170                 175     


Gln Cys Ala Asn Ile Gln Leu Arg Ser Asp Glu Glu Cys Arg Gln Val 
            180                 185                 190         


Tyr Pro Gly Lys Ile Thr Asp Asn Met Leu Cys Ala Gly Thr Lys Glu 
        195                 200                 205             


Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser Gly Gly Pro Leu Val Cys 
    210                 215                 220                 


Asn Arg Thr Leu Tyr Gly Ile Val Ser Trp Gly Asp Phe Pro Cys Gly 
225                 230                 235                 240 


Gln Pro Asp Arg Pro Gly Val Tyr Thr Arg Val Ser Arg Tyr Val Leu 
                245                 250                 255     


Trp Ile Arg Glu Thr Ile Arg Lys Tyr Glu Thr Gln Gln Gln Lys Trp 
            260                 265                 270         


Leu Lys Gly Pro Gln 
        275         


<210>  53
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  54
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Ser Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     


<210>  55
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Asp Arg Glu Gln Leu Leu Gln Arg Ala Arg Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Asp Met Ala Ser Ala Met Lys Ala Val Thr Glu 
            20                  25                  30          


Leu Asn Glu Pro Leu Ser Asn Glu Asp Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Thr Met Ala Asp Gly Asn Glu Lys Lys Leu Glu 
65                  70                  75                  80  


Lys Val Lys Ala Tyr Arg Glu Lys Ile Glu Lys Glu Leu Glu Thr Val 
                85                  90                  95      


Cys Asn Asp Val Leu Ser Leu Leu Asp Lys Phe Leu Ile Lys Asn Cys 
            100                 105                 110         


Asn Asp Phe Gln Tyr Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly 
        115                 120                 125             


Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala Ser Gly Glu Lys Lys Asn 
    130                 135                 140                 


Ser Val Val Glu Ala Ser Glu Ala Ala Tyr Lys Glu Ala Phe Glu Ile 
145                 150                 155                 160 


Ser Lys Glu Gln Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala 
                165                 170                 175     


Leu Asn Phe Ser Val Phe Tyr Tyr Glu Ile Gln Asn Ala Pro Glu Gln 
            180                 185                 190         


Ala Cys Leu Leu Ala Lys Gln Ala Phe Asp Asp Ala Ile Ala Glu Leu 
        195                 200                 205             


Asp Thr Leu Asn Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln 
    210                 215                 220                 


Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Gln Gln Asp Glu 
225                 230                 235                 240 


Glu Ala Gly Glu Gly Asn 
                245     


<210>  56
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  57
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Asn Tyr Ser Lys Ile Pro Ala Gln Val Asp Leu Arg Arg Gln Ala 
1               5                   10                  15      


Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn Phe Asp 
            20                  25                  30          


Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys Asp Pro 
        35                  40                  45              


Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser Val Asp 
    50                  55                  60                  


Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg Leu Leu 
65                  70                  75                  80  


Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr Asp Thr 
                85                  90                  95      


Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala Ser Phe 
            100                 105                 110         


Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp Tyr Asp 
        115                 120                 125             


Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp Gly Thr 
    130                 135                 140                 


Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn Gly Leu 
145                 150                 155                 160 


Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu Leu Cys 
                165                 170                 175     


Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys Asp Gly 
            180                 185                 190         


Arg Ser Glu Arg Asn Leu Leu 
        195                 


<210>  58
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Pro Pro Gly Lys Pro Gln Gly Pro Pro Pro Gln Gly Gly Asn Gln 
1               5                   10                  15      


Pro Gln Gly Pro Pro Pro Pro Pro Gly Lys Pro Gln Gly Pro Pro Pro 
            20                  25                  30          


Gln Gly Gly Asn Lys Pro Gln Gly Pro Pro Pro Pro Gly Lys Pro Gln 
        35                  40                  45              


Gly Pro Pro Pro Gln Gly Asp Asn Lys Ser Gln Ser Ala Lys Pro Gln 
    50                  55                  60                  


Gly Pro Pro Pro Gln Gly Gly Lys Pro Gln Gly Pro Pro Pro Gln Gly 
65                  70                  75                  80  


Gly Asn Lys Pro Gln Gly Pro Pro Pro Gln Gly Lys Ser Ala Arg Ser 
                85                  90                  95      


Pro Pro Gly Lys Pro Gln Gly Pro Pro Gln Gln Glu Gly Asn Asn Pro 
            100                 105                 110         


Gln Gly Pro Pro Pro Pro Ala Gly Gly Asn Pro Gly Ser Lys Ser Arg 
        115                 120                 125             


<210>  59
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  60
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Lys Asn Thr Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg Gln 
        35                  40                  45              


Gly Asn Met Thr Ala Ala Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile 
    50                  55                  60                  


Asn Thr Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser Ile Val Leu 
65                  70                  75                  80  


Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys Ala Val Gln 
                85                  90                  95      


Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr Ile Tyr Lys 
            100                 105                 110         


Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu Leu Gln Trp 
        115                 120                 125             


His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile Val Arg Val 
    130                 135                 140                 


Leu Thr Ala Arg Lys Thr Val 
145                 150     


<210>  61
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asp Pro Ala Arg Lys Ala Gly Ala Gln Ala Met Ile Trp Thr Ala 
1               5                   10                  15      


Gly Trp Leu Leu Leu Leu Leu Leu Arg Gly Gly Ala Gln Ala Leu Glu 
            20                  25                  30          


Cys Tyr Ser Cys Val Gln Lys Ala Asp Asp Gly Cys Ser Pro Asn Lys 
        35                  40                  45              


Met Lys Thr Val Lys Cys Ala Pro Gly Val Asp Val Cys Thr Glu Ala 
    50                  55                  60                  


Val Gly Ala Val Glu Thr Ile His Gly Gln Phe Ser Leu Ala Val Arg 
65                  70                  75                  80  


Gly Cys Gly Ser Gly Leu Pro Gly Lys Asn Asp Arg Gly Leu Asp Leu 
                85                  90                  95      


His Gly Leu Leu Ala Phe Ile Gln Leu Gln Gln Cys Ala Gln Asp Arg 
            100                 105                 110         


Cys Asn Ala Lys Leu Asn Leu Thr Ser Arg Ala Leu Asp Pro Ala Gly 
        115                 120                 125             


Asn Glu Ser Ala Tyr Pro Pro Asn Gly Val Glu Cys Tyr Ser Cys Val 
    130                 135                 140                 


Gly Leu Ser Arg Glu Ala Cys Gln Gly Thr Ser Pro Pro Val Val Ser 
145                 150                 155                 160 


Cys Tyr Asn Ala Ser Asp His Val Tyr Lys Gly Cys Phe Asp Gly Asn 
                165                 170                 175     


Val Thr Leu Thr Ala Ala Asn Val Thr Val Ser Leu Pro Val Arg Gly 
            180                 185                 190         


Cys Val Gln Asp Glu Phe Cys Thr Arg Asp Gly Val Thr Gly Pro Gly 
        195                 200                 205             


Phe Thr Leu Ser Gly Ser Cys Cys Gln Gly Ser Arg Cys Asn Ser Asp 
    210                 215                 220                 


Leu Arg Asn Lys Thr Tyr Phe Ser Pro Arg Ile Pro Pro Leu Val Arg 
225                 230                 235                 240 


Leu Pro Pro Pro Glu Pro Thr Thr Val Ala Ser Thr Thr Ser Val Thr 
                245                 250                 255     


Thr Ser Thr Ser Ala Pro Val Arg Pro Thr Ser Thr Thr Lys Pro Met 
            260                 265                 270         


Pro Ala Pro Thr Ser Gln Thr Pro Arg Gln Gly Val Glu His Glu Ala 
        275                 280                 285             


Ser Arg Asp Glu Glu Pro Arg Leu Thr Gly Gly Ala Ala Gly His Gln 
    290                 295                 300                 


Asp Arg Ser Asn Ser Gly Gln Tyr Pro Ala Lys Gly Gly Pro Gln Gln 
305                 310                 315                 320 


Pro His Asn Lys Gly Cys Val Ala Pro Thr Ala Gly Leu Ala Ala Leu 
                325                 330                 335     


Leu Leu Ala Val Ala Ala Gly Val Leu Leu 
            340                 345     


<210>  62
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Thr Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Thr Thr Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys Asp Leu Met Val Gly Asp Glu Ala Ser Glu Leu 
    50                  55                  60                  


Arg Ser Met Leu Glu Val Asn Tyr Pro Met Glu Asn Gly Ile Val Arg 
65                  70                  75                  80  


Asn Trp Asp Asp Met Lys His Leu Trp Asp Tyr Thr Phe Gly Pro Glu 
                85                  90                  95      


Lys Leu Asn Ile Asp Thr Arg Asn Cys Lys Ile Leu Leu Thr Glu Pro 
            100                 105                 110         


Pro Met Asn Pro Thr Lys Asn Arg Glu Lys Ile Val Glu Val Met Phe 
        115                 120                 125             


Glu Thr Tyr Gln Phe Ser Gly Val Tyr Val Ala Ile Gln Ala Val Leu 
    130                 135                 140                 


Thr Leu Tyr Ala Gln Gly Leu Leu Thr Gly Val Val Val Asp Ser Gly 
145                 150                 155                 160 


Asp Gly Val Thr His Ile Cys Pro Val Tyr Glu Gly Phe Ser Leu Pro 
                165                 170                 175     


His Leu Thr Arg Arg Leu Asp Ile Ala Gly Arg Asp Ile Thr Arg Tyr 
            180                 185                 190         


Leu Ile Lys Leu Leu Leu Leu Arg Gly Tyr Ala Phe Asn His Ser Ala 
        195                 200                 205             


Asp Phe Glu Thr Val Arg Met Ile Lys Glu Lys Leu Cys Tyr Val Gly 
    210                 215                 220                 


Tyr Asn Ile Glu Gln Glu Gln Lys Leu Ala Leu Glu Thr Thr Val Leu 
225                 230                 235                 240 


Val Glu Ser Tyr Thr Leu Pro Asp Gly Arg Ile Ile Lys Val Gly Gly 
                245                 250                 255     


Glu Arg Phe Glu Ala Pro Glu Ala Leu Phe Gln Pro His Leu Ile Asn 
            260                 265                 270         


Val Glu Gly Val Gly Val Ala Glu Leu Leu Phe Asn Thr Ile Gln Ala 
        275                 280                 285             


Ala Asp Ile Asp Thr Arg Ser Glu Phe Tyr Lys His Ile Val Leu Ser 
    290                 295                 300                 


Gly Gly Ser Thr Met Tyr Pro Gly Leu Pro Ser Arg Leu Glu Arg Glu 
305                 310                 315                 320 


Leu Lys Gln Leu Tyr Leu Glu Arg Val Leu Lys Gly Asp Val Glu Lys 
                325                 330                 335     


Leu Ser Lys Phe Lys Ile Arg Ile Glu Asp Pro Pro Arg Arg Lys His 
            340                 345                 350         


Met Val Phe Leu Gly Gly Ala Val Leu Ala Asp Ile Met Lys Asp Lys 
        355                 360                 365             


Asp Asn Phe Trp Met Thr Arg Gln Glu Tyr Gln Glu Lys Gly Val Arg 
    370                 375                 380                 


Val Leu Glu Lys Leu Gly Val Thr Val Arg 
385                 390                 


<210>  63
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10                  15      


Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile 
            20                  25                  30          


Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
    50                  55                  60                  


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Thr His Trp Pro Pro 
65                  70                  75                  80  


Ile Met Val Phe Thr Phe 
                85      


<210>  64
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu 
            20                  25                  30          


Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 
        35                  40                  45              


Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 
    50                  55                  60                  


Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 
65                  70                  75                  80  


Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala 
                85                  90                  95      


Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 
            100                 105                 110         


Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 
    130                 135                 140                 


Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln 
145                 150                 155                 160 


Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 
                165                 170                 175     


Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala 
            180                 185                 190         


Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 
        195                 200                 205             


Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr 
    210                 215                 220                 


Val Lys Glu 
225         


<210>  65
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  66
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Asn Leu Leu Lys Val Leu Thr Cys Thr Asp Leu Glu Gln Gly 
1               5                   10                  15      


Pro Asn Phe Phe Leu Asp Phe Glu Asn Ala Gln Pro Thr Glu Ser Glu 
            20                  25                  30          


Lys Glu Ile Tyr Asn Gln Val Asn Val Val Leu Lys Asp Ala Glu Gly 
        35                  40                  45              


Ile Leu Glu Asp Leu Gln Ser Tyr Arg Gly Ala Gly His Glu Ile Arg 
    50                  55                  60                  


Glu Ala Ile Gln His Pro Ala Asp Glu Lys Leu Gln Glu Lys Ala Trp 
65                  70                  75                  80  


Gly Ala Val Val Pro Leu Val Gly Lys Leu Lys Lys Phe Tyr Glu Phe 
                85                  90                  95      


Ser Gln Arg Leu Glu Ala Ala Leu Arg Gly Leu Leu Gly Ala Leu Thr 
            100                 105                 110         


Ser Thr Pro Tyr Ser Pro Thr Gln His Leu Glu Arg Glu Gln Ala Leu 
        115                 120                 125             


Ala Lys Gln Phe Ala Glu Ile Leu His Phe Thr Leu Arg Phe Asp Glu 
    130                 135                 140                 


Leu Lys Met Thr Asn Pro Ala Ile Gln Asn Asp Phe Ser Tyr Tyr Arg 
145                 150                 155                 160 


Arg Thr Leu Ser Arg Met Arg Ile Asn Asn Val Pro Ala Glu Gly Glu 
                165                 170                 175     


Asn Glu Val Asn Asn Glu Leu Ala Asn Arg Met Ser Leu Phe Tyr Ala 
            180                 185                 190         


Glu Ala Thr Pro Met Leu Lys Thr Leu Ser Asp Ala Thr Thr Lys Phe 
        195                 200                 205             


Val Ser Glu Asn Lys Asn Leu Pro Ile Glu Asn Thr Thr Asp Cys Leu 
    210                 215                 220                 


Ser Thr Met Ala Ser Val Cys Arg Val Met Leu Glu Thr Pro Glu Tyr 
225                 230                 235                 240 


Arg Ser Arg Phe Thr Asn Glu Glu Thr Val Ser Phe Cys Leu Arg Val 
                245                 250                 255     


Met Val Gly Val Ile Ile Leu Tyr Asp His Val His Pro Val Gly Ala 
            260                 265                 270         


Phe Ala Lys Thr Ser Lys Ile Asp Met Lys Gly Cys Ile Lys Val Leu 
        275                 280                 285             


Lys Asp Gln Pro Pro Asn Ser Val Glu Gly Leu Leu Asn Ala Leu Arg 
    290                 295                 300                 


Tyr Thr Thr Lys His Leu Asn Asp Glu Thr Thr Ser Lys Gln Ile Lys 
305                 310                 315                 320 


Ser Met Leu Gln 
                


<210>  67
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Thr Ile Asn Val Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                165                 170                 175     


Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
        195                 200                 205             


Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
    210                 215                 220                 


Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
225                 230                 235                 240 


Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                245                 


