                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
 
<120>  METHODS AND COMPOSITIONS FOR MODULATION OF TRANSIENT RECEPTOR 
       POTENTIAL CHANNELS

<130>  Yissum 592/2.2

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser 
1               5                   10                  15      


Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met 
            20                  25                  30          


Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu 
        35                  40                  45              


Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys 
    50                  55                  60                  


Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val 
65                  70                  75                  80  


Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn 
                85                  90                  95      


Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Lys Leu Met 
            100                 105                 110         


Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val Ala Pro 
        115                 120                 125             


Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr Met Leu 
    130                 135                 140                 


Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly Cys Glu 
145                 150                 155                 160 


Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg His Ser 
                165                 170                 175     


Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala Leu Ile 
            180                 185                 190         


Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu Ser Ala 
        195                 200                 205             


Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn Asp Tyr 
    210                 215                 220                 


Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu Leu Ala 
225                 230                 235                 240 


Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His Thr Ser 
                245                 250                 255     


Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg Met Asn 
            260                 265                 270         


Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu Phe Val 
        275                 280                 285             


Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe Gly Gln 
    290                 295                 300                 


Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met Thr Val 
305                 310                 315                 320 


Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr Leu Ile 
                325                 330                 335     


Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe Met Lys 
            340                 345                 350         


Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu Leu Asn 
        355                 360                 365             


Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met Gly Pro 
    370                 375                 380                 


Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile Gly Met 
385                 390                 395                 400 


Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu Asp Phe 
                405                 410                 415     


Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser Leu Tyr 
            420                 425                 430         


Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe His Asp 
        435                 440                 445             


Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu Val Ala 
    450                 455                 460                 


Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg Leu Phe 
465                 470                 475                 480 


Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile Ser Met 
                485                 490                 495     


Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe Leu Leu 
            500                 505                 510         


Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp Lys Gly 
        515                 520                 525             


Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys Glu Gln 
    530                 535                 540                 


Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe Ala Leu 
545                 550                 555                 560 


Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val Thr Arg 
                565                 570                 575     


Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val Ile Val 
            580                 585                 590         


Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu Leu Val 
        595                 600                 605             


Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu Asp Lys 
    610                 615                 620                 


Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Asp 
625                 630                 635                 640 


Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Thr 
                645                 650                 655     


Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser His Thr 
            660                 665                 670         


Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp Arg Asn 
        675                 680                 685             


Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys Cys Leu 
    690                 695                 700                 


Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser Thr Asp 
705                 710                 715                 720 


Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu Ser Lys 
                725                 730                 735     


Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser Lys Tyr 
            740                 745                 750         


Ala Met Phe Tyr Pro Arg Asn 
        755                 


<210>  2
<211>  1264
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Pro Val Lys Ile Ser His Val Val Ser Phe Ser Ser Gln Asp 
1               5                   10                  15      


Pro Lys Tyr Pro Val Glu Asn Leu Leu Asn Pro Asp Ser His Arg Gly 
            20                  25                  30          


Pro Trp Leu Ser Cys Pro Gln Asp Lys Thr Gly Gln Leu Lys Val Glu 
        35                  40                  45              


Phe Gln Leu Glu Arg Ala Val Pro Ile Ser Tyr Ile Asp Val Gly Asn 
    50                  55                  60                  


Cys Gly Cys Ala Phe Leu Gln Ile Asp Val Gly Arg Ser Ser Trp Pro 
65                  70                  75                  80  


Leu Asp Arg Pro Phe Val Thr Leu Leu Pro Ala Thr Met Leu Met Ser 
                85                  90                  95      


Arg Thr Asp Ser Lys Ser Gly Lys Asn Arg Ser Gly Val Arg Met Phe 
            100                 105                 110         


Lys Asp Gly Asp Phe Leu Thr Pro Ala Ser Gly Glu Ser Trp Asp Arg 
        115                 120                 125             


Leu Arg Leu Thr Cys Ser Gln Pro Phe Thr Arg His Gln Ser Phe Gly 
    130                 135                 140                 


Leu Ala Phe Leu Arg Val Arg Ser Ser Leu Gly Ser Leu Ala Asp Pro 
145                 150                 155                 160 


Val Val Asp Pro Ser Ala Pro Gly Ser Ser Gly Leu Asn Gln Asn Ser 
                165                 170                 175     


Thr Asp Val Leu Glu Ser Asp Pro Arg Pro Trp Leu Thr Asn Pro Ser 
            180                 185                 190         


Ile Arg Arg Thr Phe Phe Pro Asp Pro Gln Thr Ser Thr Lys Glu Ile 
        195                 200                 205             


Ser Glu Leu Lys Gly Met Leu Lys Gln Leu Gln Pro Gly Pro Leu Gly 
    210                 215                 220                 


Arg Ala Ala Arg Met Val Leu Ser Ala Ala Arg Lys Ala Pro Pro Ala 
225                 230                 235                 240 


Ser Val Val Ser Pro Asn Asn Ser His Gly Glu Pro Gly Pro Ser Arg 
                245                 250                 255     


Ala Glu Ser Ala Glu Pro Arg Ala Glu Glu Pro Asn Arg Lys Thr Ala 
            260                 265                 270         


Val Gly Arg Arg Lys Arg Arg Lys Val Gln Glu Pro Arg Arg Ser Leu 
        275                 280                 285             


Ser Asn Ser Ser Ser Gln Pro Asn Arg Arg Thr Gly Arg Thr Arg Gln 
    290                 295                 300                 


Arg Gln His Arg Pro Gln Thr Lys Ser Asp Asp Gly Gly Val Gln Ala 
305                 310                 315                 320 


Ala Gly Gln Cys Pro Ile Cys Ala Gly Phe Phe Ser Ile Glu Thr Leu 
                325                 330                 335     


Pro Gln His Ala Ala Thr Cys Gly Glu Ser Pro Pro Pro Gln Pro Ala 
            340                 345                 350         


Ser Pro Ala Ser Leu Ser Ser Ser Glu Ser Val Leu Arg Arg His His 
        355                 360                 365             


Val Ala Leu Thr Pro Val Pro Leu Val Pro Lys Pro Gln Pro Asn Trp 
    370                 375                 380                 


Thr Glu Ile Val Asn Lys Lys Leu Lys Phe Pro Pro Thr Leu Leu Arg 
385                 390                 395                 400 


Ala Ile Gln Glu Gly Gln Leu Gly Leu Val Gln Gln Leu Leu Glu Ser 
                405                 410                 415     


Ser Ser Asp Ala Ser Gly Ala Gly Pro Gly Gly Pro Leu Arg Asn Val 
            420                 425                 430         


Glu Glu Ser Glu Asp Arg Ser Trp Arg Glu Ala Leu Asn Leu Ala Ile 
        435                 440                 445             


Arg Leu Gly His Glu Val Ile Thr Asp Val Leu Leu Ala Asn Val Lys 
    450                 455                 460                 


Phe Asp Phe Arg Gln Ile His Glu Ala Leu Leu Val Ala Val Asp Thr 
465                 470                 475                 480 


Asn Gln Pro Ala Val Val Arg Arg Leu Leu Ala Arg Leu Glu Arg Glu 
                485                 490                 495     


Lys Gly Arg Lys Val Asp Thr Lys Ser Phe Ser Leu Ala Phe Phe Asp 
            500                 505                 510         


Ser Ser Ile Asp Gly Ser Arg Phe Ala Pro Gly Val Thr Pro Leu Thr 
        515                 520                 525             


Leu Ala Cys Gln Lys Asp Leu Tyr Glu Ile Ala Gln Leu Leu Met Asp 
    530                 535                 540                 


Gln Gly His Thr Ile Ala Arg Pro His Pro Val Ser Cys Ala Cys Leu 
545                 550                 555                 560 


Glu Cys Ser Asn Ala Arg Arg Tyr Asp Leu Leu Lys Phe Ser Leu Ser 
                565                 570                 575     


Arg Ile Asn Thr Tyr Arg Gly Ile Ala Ser Arg Ala His Leu Ser Leu 
            580                 585                 590         


Ala Ser Glu Asp Ala Met Leu Ala Ala Phe Gln Leu Ser Arg Glu Leu 
        595                 600                 605             


Arg Arg Leu Ala Arg Lys Glu Pro Glu Phe Lys Pro Gln Tyr Ile Ala 
    610                 615                 620                 


Leu Glu Ser Leu Cys Gln Asp Tyr Gly Phe Glu Leu Leu Gly Met Cys 
625                 630                 635                 640 


Arg Asn Gln Ser Glu Val Thr Ala Val Leu Asn Asp Leu Gly Glu Asp 
                645                 650                 655     


Ser Glu Thr Glu Pro Glu Ala Glu Gly Leu Gly Gln Ala Phe Glu Glu 
            660                 665                 670         


Gly Ile Pro Asn Leu Ala Arg Leu Arg Leu Ala Val Asn Tyr Asn Gln 
        675                 680                 685             


Lys Gln Phe Val Ala His Pro Ile Cys Gln Gln Val Leu Ser Ser Ile 
    690                 695                 700                 


Trp Cys Gly Asn Leu Ala Gly Trp Arg Gly Ser Thr Thr Ile Trp Lys 
705                 710                 715                 720 


Leu Phe Val Ala Phe Leu Ile Phe Leu Thr Met Pro Phe Leu Cys Ile 
                725                 730                 735     


Gly Tyr Trp Leu Ala Pro Lys Ser Gln Leu Gly Arg Leu Leu Lys Ile 
            740                 745                 750         


Pro Val Leu Lys Phe Leu Leu His Ser Ala Ser Tyr Leu Trp Phe Leu 
        755                 760                 765             


Ile Phe Leu Leu Gly Glu Ser Leu Val Met Glu Thr Gln Leu Ser Thr 
    770                 775                 780                 


Phe Lys Gly Arg Ser Gln Ser Val Trp Glu Thr Ser Leu His Met Ile 
785                 790                 795                 800 


Trp Val Thr Gly Phe Leu Trp Phe Glu Cys Lys Glu Val Trp Ile Glu 
                805                 810                 815     


Gly Leu Arg Ser Tyr Leu Leu Asp Trp Trp Asn Phe Leu Asp Val Val 
            820                 825                 830         


Ile Leu Ser Leu Tyr Leu Ala Ser Phe Ala Leu Arg Leu Leu Leu Ala 
        835                 840                 845             


Gly Leu Ala Tyr Met His Cys Arg Asp Ala Ser Asp Ser Thr Thr Cys 
    850                 855                 860                 


Arg Tyr Phe Thr Thr Ala Glu Arg Ser Glu Trp Arg Thr Glu Asp Pro 
865                 870                 875                 880 


Gln Phe Leu Ala Glu Val Leu Phe Ala Val Thr Ser Met Leu Ser Phe 
                885                 890                 895     


Thr Arg Leu Ala Tyr Ile Leu Pro Ala His Glu Ser Leu Gly Thr Leu 
            900                 905                 910         


Gln Ile Ser Ile Gly Lys Met Ile Asp Asp Met Ile Arg Phe Met Phe 
        915                 920                 925             


Ile Leu Met Ile Ile Leu Thr Ala Phe Leu Cys Gly Leu Asn Asn Ile 
    930                 935                 940                 


Tyr Val Pro Tyr Gln Glu Ser Glu Lys Leu Gly Asn Phe Asn Glu Thr 
945                 950                 955                 960 


Phe Gln Phe Leu Phe Trp Thr Met Phe Gly Met Glu Glu His Thr Val 
                965                 970                 975     


Val Asp Met Pro Gln Phe Leu Val Pro Glu Phe Val Gly Arg Ala Met 
            980                 985                 990         


Tyr Gly Ile Phe Thr Ile Val Met  Val Ile Val Leu Leu  Asn Met Leu 
        995                 1000                 1005             


Ile Ala  Met Ile Thr Asn Ser  Phe Gln Lys Ile Glu  Asp Asp Ala 
    1010                 1015                 1020             


Asp Val  Glu Trp Lys Phe Ala  Arg Ser Lys Leu Tyr  Leu Ser Tyr 
    1025                 1030                 1035             


Phe Arg  Glu Gly Leu Thr Leu  Pro Val Pro Phe Asn  Ile Leu Pro 
    1040                 1045                 1050             


Ser Pro  Lys Ala Ala Phe Tyr  Leu Val Arg Arg Ile  Phe Arg Phe 
    1055                 1060                 1065             


Leu Cys  Cys Gly Ser Ser Cys  Cys Lys Ala Lys Lys  Ser Asp Tyr 
    1070                 1075                 1080             


Pro Pro  Ile Gly Thr Phe Thr  Asn Pro Gly Ala Arg  Ala Gly Ser 
    1085                 1090                 1095             


Ala Gly  Glu Gly Glu Arg Val  Ser Tyr Arg Leu Arg  Val Ile Lys 
    1100                 1105                 1110             


Ala Leu  Val Gln Arg Tyr Ile  Glu Thr Ala Arg Arg  Glu Phe Glu 
    1115                 1120                 1125             


Glu Thr  Arg Arg Lys Asp Leu  Gly Asn Arg Leu Thr  Glu Leu Thr 
    1130                 1135                 1140             


Lys Thr  Val Ser Arg Leu Gln  Ser Glu Val Ala Ser  Val Gln Lys 
    1145                 1150                 1155             


Asn Leu  Ala Ala Gly Gly Ala  Pro Arg Pro Pro Asp  Gly Ala Ser 
    1160                 1165                 1170             


Ile Leu  Ser Arg Tyr Ile Thr  Arg Val Arg Asn Ser  Phe Gln Asn 
    1175                 1180                 1185             


Leu Gly  Pro Pro Thr Ser Asp  Thr Pro Ala Glu Leu  Thr Met Pro 
    1190                 1195                 1200             


Gly Ile  Val Glu Thr Glu Val  Ser Leu Gly Asp Gly  Leu Asp Gly 
    1205                 1210                 1215             


Thr Gly  Glu Ala Gly Ala Pro  Ala Pro Gly Glu Pro  Gly Ser Ser 
    1220                 1225                 1230             


Ser Ser  Ala His Val Leu Val  His Arg Glu Gln Glu  Ala Glu Gly 
    1235                 1240                 1245             


Ser Gly  Asp Leu Leu Leu Glu  Gly Asp Leu Glu Thr  Lys Gly Glu 
    1250                 1255                 1260             


Ser 
    


<210>  3
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Thr Lys Val Arg Lys Cys Lys Glu Gln Ala Arg Val Thr Phe 
1               5                   10                  15      


Pro Ala Pro Glu Glu Glu Glu Asp Glu Gly Glu Asp Glu Gly Ala Glu 
            20                  25                  30          


Pro Gln Arg Arg Arg Arg Gly Trp Arg Gly Val Asn Gly Gly Leu Glu 
        35                  40                  45              


Pro Arg Ser Ala Pro Ser Gln Arg Glu Pro His Gly Tyr Cys Pro Pro 
    50                  55                  60                  


Pro Phe Ser His Gly Pro Asp Leu Ser Met Glu Gly Ser Pro Ser Leu 
65                  70                  75                  80  


Arg Arg Met Thr Val Met Arg Glu Lys Gly Arg Arg Gln Ala Val Arg 
                85                  90                  95      


Gly Pro Ala Phe Met Phe Asn Asp Arg Gly Thr Ser Leu Thr Ala Glu 
            100                 105                 110         


Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val 
        115                 120                 125             


Arg Lys Met Leu Glu Glu Ser Lys Thr Leu Asn Val Asn Cys Val Asp 
    130                 135                 140                 


Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu 
145                 150                 155                 160 


Glu Val Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly 
                165                 170                 175     


Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu 
            180                 185                 190         


Ala Ile Leu Asn His Pro Gly Phe Ala Ala Ser Lys Arg Leu Thr Leu 
        195                 200                 205             


Ser Pro Cys Glu Gln Glu Leu Gln Asp Asp Asp Phe Tyr Ala Tyr Asp 
    210                 215                 220                 


Glu Asp Gly Thr Arg Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala 
225                 230                 235                 240 


Ala His Cys Gln Lys Tyr Glu Val Val His Met Leu Leu Met Lys Gly 
                245                 250                 255     


Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Gly Asp Cys 
            260                 265                 270         


Met Glu Lys Gln Arg His Asp Ser Phe Ser His Ser Arg Ser Arg Ile 
        275                 280                 285             


Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser 
    290                 295                 300                 


Glu Asp Pro Val Leu Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys 
305                 310                 315                 320 


Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser 
                325                 330                 335     


Met Gln Cys Lys Asp Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp 
            340                 345                 350         


Ser Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Leu Glu Ser Ala Glu 
        355                 360                 365             


Pro Leu Glu Val His Arg His Lys Ala Ser Leu Ser Arg Val Lys Leu 
    370                 375                 380                 


Ala Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln 
385                 390                 395                 400 


Gln Gln Leu Leu Thr Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu 
                405                 410                 415     


Gln Thr Ile Ala Ile Lys Cys Leu Val Val Leu Val Val Ala Leu Gly 
            420                 425                 430         


Leu Pro Phe Leu Ala Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu 
        435                 440                 445             


Gly Lys Ile Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala 
    450                 455                 460                 


Ser Phe Ile Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg 
465                 470                 475                 480 


Phe Glu Gly Ile Thr Thr Leu Pro Asn Ile Thr Val Thr Asp Tyr Pro 
                485                 490                 495     


Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met 
            500                 505                 510         


Leu Ile Met Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu 
        515                 520                 525             


Leu Trp Leu Glu Gly Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val 
    530                 535                 540                 


Leu Asp Phe Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg 
545                 550                 555                 560 


Phe Leu Ala Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser 
                565                 570                 575     


Tyr Val Gln Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile 
            580                 585                 590         


Gln Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln 
        595                 600                 605             


Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
    610                 615                 620                 


Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
625                 630                 635                 640 


Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu 
                645                 650                 655     


Phe Ile Met Val Phe Phe Ala Phe Met Ile Gly Met Phe Ile Leu Tyr 
            660                 665                 670         


Ser Tyr Tyr Leu Gly Ala Lys Val Asn Ala Ala Phe Thr Thr Val Glu 
        675                 680                 685             


Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val 
    690                 695                 700                 


Thr Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly 
705                 710                 715                 720 


Tyr Val Leu Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu 
                725                 730                 735     


Asn Met Leu Ile Ala Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp 
            740                 745                 750         


Asp Ser Asp Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser 
        755                 760                 765             


Tyr Phe Asp Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro 
    770                 775                 780                 


Ser Pro Lys Ser Phe Val Tyr Phe Ile Met Arg Ile Val Asn Phe Pro 
785                 790                 795                 800 


Lys Cys Arg Arg Arg Arg Leu Gln Lys Asp Ile Glu Met Gly Met Gly 
                805                 810                 815     


Asn Ser Lys Ser Arg Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val 
            820                 825                 830         


Phe Glu Ser His Ser Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr 
        835                 840                 845             


Gln Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln 
    850                 855                 860                 


Val Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile 
865                 870                 875                 880 


Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser 
                885                 890                 895     


Gln Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys 
            900                 905                 910         


Leu Asn Pro Ser Met Leu Arg Cys Glu 
        915                 920     


<210>  4
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      


Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          


Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              


Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  


Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  


Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      


Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         


Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             


Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 


Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 


Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     


His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         


Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             


Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 


Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 


Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     


Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         


Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             


Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 


Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe 
305                 310                 315                 320 


Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu 
                325                 330                 335     


Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val 
            340                 345                 350         


Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp 
        355                 360                 365             


Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met 
    370                 375                 380                 


Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu 
385                 390                 395                 400 


Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn 
                405                 410                 415     


Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr 
            420                 425                 430         


Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met 
        435                 440                 445             


Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr 
    450                 455                 460                 


Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe 
465                 470                 475                 480 


Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys 
                485                 490                 495     


Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu 
            500                 505                 510         


Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys 
        515                 520                 525             


Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile 
    530                 535                 540                 


Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn 
545                 550                 555                 560 


Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp 
                565                 570                 575     


Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met 
            580                 585                 590         


Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn 
        595                 600                 605             


Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser 
    610                 615                 620                 


Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His 
625                 630                 635                 640 


Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val 
                645                 650                 655     


Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser 
            660                 665                 670         


Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala 
        675                 680                 685             


Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro 
    690                 695                 700                 


Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile 
705                 710                 715                 720 


Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys 
                725                 730                 735     


Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Leu Asn Leu Phe 
            740                 745                 750         


Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser Phe Asn Ser Ile 
        755                 760                 765             


Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys Arg Leu Ile Lys 
    770                 775                 780                 


Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn 
785                 790                 795                 800 


Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                805                 810                 815     


Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu 
            820                 825                 830         


Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu 
        835                 840                 845             


<210>  5
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His 
    690                 695                 700                 


Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala 
705                 710                 715                 720 


Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe 
                725                 730                 735     


Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly 
            740                 745                 750         


Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser 
        755                 760                 765             


Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu 
    770                 775                 780                 


Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe Asp Leu Thr 
785                 790                 795                 800 


Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu Arg His Asn 
                805                 810                 815     


Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro Arg Glu Lys 
            820                 825                 830         


Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe Gly Leu Phe 
        835                 840                 845             


His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala Asn Gln Ile 
    850                 855                 860                 


Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu 
865                 870                 875                 880 


Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp 
                885                 890                 895     


Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg 
            900                 905                 910         


Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys 
        915                 920                 925             


Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile 
    930                 935                 940                 


Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp 
945                 950                 955                 960 


Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg 
                965                 970                 975     


Leu 
    


<210>  6
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His 
    690                 695                 700                 


Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala 
705                 710                 715                 720 


Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe 
                725                 730                 735     


Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly 
            740                 745                 750         


Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser 
        755                 760                 765             


Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu 
    770                 775                 780                 


Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Glu Arg Asn Ile 
785                 790                 795                 800 


Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro 
                805                 810                 815     


Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr 
            820                 825                 830         


Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser 
        835                 840                 845             


Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys 
    850                 855                 860                 


His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro 
865                 870                 875                 880 


Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu 
                885                 890             


<210>  7
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Arg Arg Ala Ala Asp Asn Leu Arg Arg His His Gln 
625                 630                 635                 640 


Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala Met 
                645                 650                 655     


Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe Lys 
            660                 665                 670         


Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly Leu 
        675                 680                 685             


Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser Lys 
    690                 695                 700                 


Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu Glu 
705                 710                 715                 720 


Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln 
                725                 730                 735     


Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly 
            740                 745                 750         


Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr Asp 
        755                 760                 765             


Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser Glu 
    770                 775                 780                 


Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys His 
785                 790                 795                 800 


Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp 
                805                 810                 815     


Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu 
            820                 825             


<210>  8
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His 
    690                 695                 700                 


Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala 
705                 710                 715                 720 


Met Ile Arg Asp Ala Lys Thr Glu Glu Val Ala Arg Gln Gln Ala Ala 
                725                 730                 735     


Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser 
            740                 745                 750         


Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val 
        755                 760                 765             


Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys 
    770                 775                 780                 


Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val 
785                 790                 795                 800 


Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile 
                805                 810                 815     


Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val 
            820                 825                 830         


Thr Thr Arg Leu 
        835     


<210>  9
<211>  982
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser 
    210                 215                 220                 


Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg 
            260                 265                 270         


Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg 
        275                 280                 285             


Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro 
    290                 295                 300                 


Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly 
305                 310                 315                 320 


Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile 
                325                 330                 335     


Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys 
            340                 345                 350         


Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys 
        355                 360                 365             


His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser 
    370                 375                 380                 


Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr 
385                 390                 395                 400 


Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly 
                405                 410                 415     


Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp 
            420                 425                 430         


Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr 
        435                 440                 445             


Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro 
    450                 455                 460                 


Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu 
465                 470                 475                 480 


Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe 
                485                 490                 495     


Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met 
            500                 505                 510         


Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu 
        515                 520                 525             


Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr 
    530                 535                 540                 


Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala 
545                 550                 555                 560 


Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe 
                565                 570                 575     


Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe 
            580                 585                 590         


Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser 
        595                 600                 605             


Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr 
    610                 615                 620                 


Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr 
625                 630                 635                 640 


Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro 
                645                 650                 655     


Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp 
            660                 665                 670         


Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser 
        675                 680                 685             


Phe Gly Thr Ile Gly Val Arg Thr Gln His Arg Arg Ala Ala Asp Asn 
    690                 695                 700                 


Leu Arg Arg His His Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys 
705                 710                 715                 720 


Arg Tyr Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu 
                725                 730                 735     


Thr Glu Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg 
            740                 745                 750         


Phe Glu Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln 
        755                 760                 765             


Ser Ala Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu 
    770                 775                 780                 


Lys Ser Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser 
785                 790                 795                 800 


Leu Phe Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala 
                805                 810                 815     


Ser Glu Arg His Asn Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu 
            820                 825                 830         


Pro Pro Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys 
        835                 840                 845             


Asn Phe Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln 
    850                 855                 860                 


Asn Ala Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln 
865                 870                 875                 880 


Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu 
                885                 890                 895     


Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val 
            900                 905                 910         


Leu Val Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val 
        915                 920                 925             


Gly Lys Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp 
    930                 935                 940                 


Thr Val Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser 
945                 950                 955                 960 


Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp 
                965                 970                 975     


Tyr Val Thr Thr Arg Leu 
            980         


<210>  10
<211>  804
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser 
            20                  25                  30          


Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val 
        35                  40                  45              


Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn 
    50                  55                  60                  


Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Phe Val 
        115                 120                 125             


Ala Gln Pro Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu 
    130                 135                 140                 


Phe Pro Gly Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys 
145                 150                 155                 160 


Phe Ile Ile Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile 
                165                 170                 175     


Ala Pro Lys Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys 
            180                 185                 190         


Phe Ile Cys His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu 
        195                 200                 205             


Leu Ala Ser Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro 
    210                 215                 220                 


Pro Pro Thr Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe 
225                 230                 235                 240 


Ile Trp Gly Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr 
                245                 250                 255     


Ile His Asp Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr 
            260                 265                 270         


Leu Ala Thr Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala 
        275                 280                 285             


Leu Asn Pro Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala 
    290                 295                 300                 


Glu Ala Leu Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile 
305                 310                 315                 320 


Ser Leu Phe Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu 
                325                 330                 335     


Gly Arg Met Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu 
            340                 345                 350         


Val Leu Leu Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr 
        355                 360                 365             


Glu Glu Thr Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln 
    370                 375                 380                 


Asn Asn Ala Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp 
385                 390                 395                 400 


Ser Ile Phe Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln 
                405                 410                 415     


His Glu Phe Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn 
            420                 425                 430         


Val Ile Ser Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn 
        435                 440                 445             


Asn Ser Tyr Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe 
    450                 455                 460                 


Ala Arg Thr Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu 
465                 470                 475                 480 


Pro Thr Pro Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu 
                485                 490                 495     


Ile Lys Trp Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys 
            500                 505                 510         


Pro Glu Ser Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg 
        515                 520                 525             


Arg His His Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr 
    530                 535                 540                 


Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu 
545                 550                 555                 560 


Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu 
                565                 570                 575     


Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala 
            580                 585                 590         


Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser 
        595                 600                 605             


Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe 
    610                 615                 620                 


Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu 
625                 630                 635                 640 


Arg His Asn Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro 
                645                 650                 655     


Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe 
            660                 665                 670         


Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala 
        675                 680                 685             


Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala 
    690                 695                 700                 


Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser 
705                 710                 715                 720 


Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val 
                725                 730                 735     


Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys 
            740                 745                 750         


Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val 
        755                 760                 765             


Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile 
    770                 775                 780                 


Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val 
785                 790                 795                 800 


Thr Thr Arg Leu 
                


<210>  11
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gln Leu Tyr Tyr Lys Lys Val Asn Tyr Ser Pro Tyr Arg Asp 
1               5                   10                  15      


Arg Ile Pro Leu Gln Ile Val Arg Ala Glu Thr Glu Leu Ser Ala Glu 
            20                  25                  30          


Glu Lys Ala Phe Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Thr Val 
        35                  40                  45              


Lys Gln Ala Leu Gln Glu Ala Glu Ile Tyr Tyr Asn Val Asn Ile Asn 
    50                  55                  60                  


Cys Met Asp Pro Leu Gly Arg Ser Ala Leu Leu Ile Ala Ile Glu Asn 
65                  70                  75                  80  


Glu Asn Leu Glu Ile Met Glu Leu Leu Leu Asn His Ser Val Tyr Val 
                85                  90                  95      


Gly Asp Ala Leu Leu Tyr Ala Ile Arg Lys Glu Val Val Gly Ala Val 
            100                 105                 110         


Glu Leu Leu Leu Ser Tyr Arg Arg Pro Ser Gly Glu Lys Gln Val Pro 
        115                 120                 125             


Thr Leu Met Met Asp Thr Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr 
    130                 135                 140                 


Pro Ile Met Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu 
145                 150                 155                 160 


Leu Val Gln Lys Arg Val Thr Ile Pro Arg Pro His Gln Ile Arg Cys 
                165                 170                 175     


Asn Cys Val Glu Cys Val Ser Ser Ser Glu Val Asp Ser Leu Arg His 
            180                 185                 190         


Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu 
        195                 200                 205             


Ile Ala Leu Ser Ser Glu Asp Pro Ile Leu Thr Ala Phe Arg Leu Gly 
    210                 215                 220                 


Trp Glu Leu Lys Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ala Glu 
225                 230                 235                 240 


Tyr Glu Glu Leu Ser Gln Gln Cys Lys Leu Phe Ala Lys Asp Leu Leu 
                245                 250                 255     


Asp Gln Ala Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn His Arg 
            260                 265                 270         


Asp Asp His Ser Glu Glu Leu Asp Pro Gln Lys Tyr His Asp Leu Ala 
        275                 280                 285             


Lys Leu Lys Val Ala Ile Lys Tyr His Gln Lys Glu Phe Val Ala Gln 
    290                 295                 300                 


Pro Asn Cys Gln Gln Leu Leu Ala Thr Leu Trp Tyr Asp Gly Phe Pro 
305                 310                 315                 320 


Gly Trp Arg Arg Lys His Trp Val Val Lys Leu Leu Thr Cys Met Thr 
                325                 330                 335     


Ile Gly Phe Leu Phe Pro Met Leu Ser Ile Ala Tyr Leu Ile Ser Pro 
            340                 345                 350         


Arg Ser Asn Leu Gly Leu Phe Ile Lys Lys Pro Phe Ile Lys Phe Ile 
        355                 360                 365             


Cys His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Met Leu Leu Leu Ala 
    370                 375                 380                 


Ser Gln His Ile Val Arg Thr Asp Leu His Val Gln Gly Pro Pro Pro 
385                 390                 395                 400 


Thr Val Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp 
                405                 410                 415     


Gly Glu Ile Lys Glu Met Trp Asp Gly Gly Phe Thr Glu Tyr Ile His 
            420                 425                 430         


Asp Trp Trp Asn Leu Met Asp Phe Ala Met Asn Ser Leu Tyr Leu Ala 
        435                 440                 445             


Thr Ile Ser Leu Lys Ile Val Ala Tyr Val Lys Tyr Asn Gly Ser Arg 
    450                 455                 460                 


Pro Arg Glu Glu Trp Glu Met Trp His Pro Thr Leu Ile Ala Glu Ala 
465                 470                 475                 480 


Leu Phe Ala Ile Ser Asn Ile Leu Ser Ser Leu Arg Leu Ile Ser Leu 
                485                 490                 495     


Phe Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg 
            500                 505                 510         


Met Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu 
        515                 520                 525             


Leu Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Thr 
    530                 535                 540                 


Arg Ala Ile Asp Glu Pro Asn Asn Cys Lys Gly Ile Arg Cys Glu Lys 
545                 550                 555                 560 


Gln Asn Asn Ala Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe 
                565                 570                 575     


Trp Ser Val Phe Gly Leu Leu Asn Leu Tyr Val Thr Asn Val Lys Ala 
            580                 585                 590         


Arg His Glu Phe Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr 
        595                 600                 605             


Asn Val Ile Ser Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met 
    610                 615                 620                 


Asn Asn Ser Tyr Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys 
625                 630                 635                 640 


Phe Ala Arg Thr Lys Leu Trp Met Ser Tyr Phe Asp Glu Gly Gly Thr 
                645                 650                 655     


Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Ser Phe Leu Tyr 
            660                 665                 670         


Leu Gly Asn Trp Phe Asn Asn Thr Phe Cys Pro Lys Arg Asp Pro Asp 
        675                 680                 685             


Gly Arg Arg Arg Arg Arg Asn Leu Arg Ser Phe Thr Glu Arg Asn Ala 
    690                 695                 700                 


Asp Ser Leu Ile Gln Asn Gln His Tyr Gln Glu Val Ile Arg Asn Leu 
705                 710                 715                 720 


Val Lys Arg Tyr Val Ala Ala Met Ile Arg Asn Ser Lys Thr His Glu 
                725                 730                 735     


Gly Leu Thr Glu Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser 
            740                 745                 750         


Phe Arg Tyr Glu Val Leu Asp Leu Leu Gly Asn Arg Lys His Pro Arg 
        755                 760                 765             


Ser Phe Ser Thr Ser Ser Thr Glu Leu Ser Gln Arg Asp Asp Asn Asn 
    770                 775                 780                 


Asp Gly Ser Gly Gly Ala Arg Ala Lys Ser Lys Ser Val Ser Phe Asn 
785                 790                 795                 800 


Leu Gly Cys Lys Lys Lys Thr Cys His Gly Pro Pro Leu Ile Arg Thr 
                805                 810                 815     


Met Pro Arg Ser Ser Gly Ala Gln Gly Lys Ser Lys Ala Glu Ser Ser 
            820                 825                 830         


Ser Lys Arg Ser Phe Met Gly Pro Ser Leu Lys Lys Leu Gly Leu Leu 
        835                 840                 845             


Phe Ser Lys Phe Asn Gly His Met Ser Glu Pro Ser Ser Glu Pro Met 
    850                 855                 860                 


Tyr Thr Ile Ser Asp Gly Ile Val Gln Gln His Cys Met Trp Gln Asp 
865                 870                 875                 880 


Ile Arg Tyr Ser Gln Met Glu Lys Gly Lys Ala Glu Ala Cys Ser Gln 
                885                 890                 895     


Ser Glu Ile Asn Leu Ser Glu Val Glu Leu Gly Glu Val Gln Gly Ala 
            900                 905                 910         


Ala Gln Ser Ser Glu Cys Pro Leu Ala Cys Ser Ser Ser Leu His Cys 
        915                 920                 925             


Ala Ser Ser Ile Cys Ser Ser Asn Ser Lys Leu Leu Asp Ser Ser Glu 
    930                 935                 940                 


Asp Val Phe Glu Thr Trp Gly Glu Ala Cys Asp Leu Leu Met His Lys 
945                 950                 955                 960 


Trp Gly Asp Gly Gln Glu Glu Gln Val Thr Thr Arg Leu 
                965                 970             


<210>  12
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Gln Ser Pro Ala Phe Gly Pro Arg Arg Gly Ser Ser Pro Arg 
1               5                   10                  15      


Gly Ala Ala Gly Ala Ala Ala Arg Arg Asn Glu Ser Gln Asp Tyr Leu 
            20                  25                  30          


Leu Met Asp Ser Glu Leu Gly Glu Asp Gly Cys Pro Gln Ala Pro Leu 
        35                  40                  45              


Pro Cys Tyr Gly Tyr Tyr Pro Cys Phe Arg Gly Ser Asp Asn Arg Leu 
    50                  55                  60                  


Ala His Arg Arg Gln Thr Val Leu Arg Glu Lys Gly Arg Arg Leu Ala 
65                  70                  75                  80  


Asn Arg Gly Pro Ala Tyr Met Phe Ser Asp Arg Ser Thr Ser Leu Ser 
                85                  90                  95      


Ile Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro 
            100                 105                 110         


Val Val Arg Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys 
        115                 120                 125             


Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu 
    130                 135                 140                 


His Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg 
145                 150                 155                 160 


Val Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile 
                165                 170                 175     


Val Glu Ala Ile Leu Ser His Pro Ala Phe Ala Glu Gly Lys Arg Leu 
            180                 185                 190         


Ala Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala 
        195                 200                 205             


Tyr Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile 
    210                 215                 220                 


Leu Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg 
225                 230                 235                 240 


Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Asn 
                245                 250                 255     


Asp Cys Asn Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser 
            260                 265                 270         


Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu 
        275                 280                 285             


Ser Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu 
    290                 295                 300                 


Ala Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys 
305                 310                 315                 320 


Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Cys 
                325                 330                 335     


Arg Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Val Glu Thr 
            340                 345                 350         


Leu Gln Ser Gly Asp His Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu 
        355                 360                 365             


Ala Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln 
    370                 375                 380                 


Gln Gln Leu Leu Ser Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln 
385                 390                 395                 400 


Gln Thr Met Ala Val Lys Phe Leu Val Val Leu Ala Val Ala Ile Gly 
                405                 410                 415     


Leu Pro Phe Leu Ala Leu Ile Tyr Trp Phe Ala Pro Cys Ser Lys Met 
            420                 425                 430         


Gly Lys Ile Met Arg Gly Pro Phe Met Lys Phe Val Ala His Ala Ala 
        435                 440                 445             


Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Met Asn Ala Ala Asp Arg 
    450                 455                 460                 


Phe Glu Gly Thr Lys Leu Leu Pro Asn Glu Thr Ser Thr Asp Asn Ala 
465                 470                 475                 480 


Lys Gln Leu Phe Arg Met Lys Thr Ser Cys Phe Ser Trp Met Glu Met 
                485                 490                 495     


Leu Ile Ile Ser Trp Val Ile Gly Met Ile Trp Ala Glu Cys Lys Glu 
            500                 505                 510         


Ile Trp Thr Gln Gly Pro Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met 
        515                 520                 525             


Leu Asp Phe Gly Met Leu Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg 
    530                 535                 540                 


Phe Met Ala Phe Trp His Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala 
545                 550                 555                 560 


Asn Asp Thr Leu Lys Asp Leu Thr Lys Val Thr Leu Gly Asp Asn Val 
                565                 570                 575     


Lys Tyr Tyr Asn Leu Ala Arg Ile Lys Trp Asp Pro Ser Asp Pro Gln 
            580                 585                 590         


Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
        595                 600                 605             


Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
    610                 615                 620                 


Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile 
625                 630                 635                 640 


Phe Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr 
                645                 650                 655     


Ser Tyr Tyr Ile Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu 
            660                 665                 670         


Glu Ser Phe Lys Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val 
        675                 680                 685             


Lys Ser Val Val Ile Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly 
    690                 695                 700                 


Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu 
705                 710                 715                 720 


Asn Met Leu Ile Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp 
                725                 730                 735     


Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser 
            740                 745                 750         


Tyr Phe Glu Glu Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro 
        755                 760                 765             


Ser Pro Lys Ser Leu Phe Tyr Leu Leu Leu Lys Leu Lys Lys Trp Ile 
    770                 775                 780                 


Ser Glu Leu Phe Gln Gly His Lys Lys Gly Phe Gln Glu Asp Ala Glu 
785                 790                 795                 800 


Met Asn Lys Ile Asn Glu Glu Lys Lys Leu Gly Ile Leu Gly Ser His 
                805                 810                 815     


Glu Asp Leu Ser Lys Leu Ser Leu Asp Lys Lys Gln Val Gly His Asn 
            820                 825                 830         


Lys Gln Pro Ser Ile Arg Ser Ser Glu Asp Phe His Leu Asn Ser Phe 
        835                 840                 845             


Asn Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys 
    850                 855                 860                 


Arg Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn 
865                 870                 875                 880 


Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                885                 890                 895     


Glu Leu Leu Glu Glu Lys Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu 
            900                 905                 910         


Ile Arg Glu Leu Gly Glu Lys Leu Ser Met Glu Pro Asn Gln Glu Glu 
        915                 920                 925             


Thr Asn Arg 
    930     


<210>  13
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr 
1               5                   10                  15      


Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met 
            20                  25                  30          


Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
        35                  40                  45              


Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
    50                  55                  60                  


Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn 
65                  70                  75                  80  


Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
                85                  90                  95      


Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu 
            100                 105                 110         


Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
        115                 120                 125             


Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln 
    130                 135                 140                 


Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
145                 150                 155                 160 


Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu 
                165                 170                 175     


Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
            180                 185                 190         


Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg 
        195                 200                 205             


Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly 
    210                 215                 220                 


Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
225                 230                 235                 240 


Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu 
                245                 250                 255     


Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
            260                 265                 270         


Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu 
        275                 280                 285             


Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His 
    290                 295                 300                 


Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys 
305                 310                 315                 320 


Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp 
                325                 330                 335     


Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe 
            340                 345                 350         


Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala 
        355                 360                 365             


Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro 
    370                 375                 380                 


Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly 
385                 390                 395                 400 


Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu 
                405                 410                 415     


Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys 
            420                 425                 430         


Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu 
        435                 440                 445             


Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg 
    450                 455                 460                 


Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser 
465                 470                 475                 480 


Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala 
                485                 490                 495     


Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu 
            500                 505                 510         


His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg 
        515                 520                 525             


Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr 
    530                 535                 540                 


Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro 
545                 550                 555                 560 


Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val 
                565                 570                 575     


Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala 
            580                 585                 590         


Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys 
        595                 600                 605             


Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe 
    610                 615                 620                 


Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr 
625                 630                 635                 640 


Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr 
                645                 650                 655     


Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile 
            660                 665                 670         


Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys 
        675                 680                 685             


Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr 
    690                 695                 700                 


Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr 
705                 710                 715                 720 


Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys 
                725                 730                 735     


Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys 
            740                 745                 750         


Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu 
        755                 760                 765             


Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met 
    770                 775                 780                 


Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu 
785                 790                 795                 800 


Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile 
                805                 810                 815     


Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly 
            820                 825                 830         


Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn 
        835                 840                 845             


Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile 
    850                 855                 860         


<210>  14
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Asp Ser Asn Arg Cys Cys Cys Gly Gln Phe Thr Asn Gln His 
1               5                   10                  15      


Ile Pro Pro Leu Pro Ser Ala Thr Pro Ser Lys Asn Glu Glu Glu Ser 
            20                  25                  30          


Lys Gln Val Glu Thr Gln Pro Glu Lys Trp Ser Val Ala Lys His Thr 
        35                  40                  45              


Gln Ser Tyr Pro Thr Asp Ser Tyr Gly Val Leu Glu Phe Gln Gly Gly 
    50                  55                  60                  


Gly Tyr Ser Asn Lys Ala Met Tyr Ile Arg Val Ser Tyr Asp Thr Lys 
65                  70                  75                  80  


Pro Asp Ser Leu Leu His Leu Met Val Lys Asp Trp Gln Leu Glu Leu 
                85                  90                  95      


Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn Phe Glu Met 
            100                 105                 110         


Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile Lys Ala Ala 
        115                 120                 125             


Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Ser Thr Gly Val 
    130                 135                 140                 


Ile Ser His Val Gly Asp Ala Leu Lys Asp His Ser Ser Lys Ser Arg 
145                 150                 155                 160 


Gly Arg Val Cys Ala Ile Gly Ile Ala Pro Trp Gly Ile Val Glu Asn 
                165                 170                 175     


Lys Glu Asp Leu Val Gly Lys Asp Val Thr Arg Val Tyr Gln Thr Met 
            180                 185                 190         


Ser Asn Pro Leu Ser Lys Leu Ser Val Leu Asn Asn Ser His Thr His 
        195                 200                 205             


Phe Ile Leu Ala Asp Asn Gly Thr Leu Gly Lys Tyr Gly Ala Glu Val 
    210                 215                 220                 


Lys Leu Arg Arg Leu Leu Glu Lys His Ile Ser Leu Gln Lys Ile Asn 
225                 230                 235                 240 


Thr Arg Leu Gly Gln Gly Val Pro Leu Val Gly Leu Val Val Glu Gly 
                245                 250                 255     


Gly Pro Asn Val Val Ser Ile Val Leu Glu Tyr Leu Gln Glu Glu Pro 
            260                 265                 270         


Pro Ile Pro Val Val Ile Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile 
        275                 280                 285             


Leu Ser Phe Ala His Lys Tyr Cys Glu Glu Gly Gly Ile Ile Asn Glu 
    290                 295                 300                 


Ser Leu Arg Glu Gln Leu Leu Val Thr Ile Gln Lys Thr Phe Asn Tyr 
305                 310                 315                 320 


Asn Lys Ala Gln Ser His Gln Leu Phe Ala Ile Ile Met Glu Cys Met 
                325                 330                 335     


Lys Lys Lys Glu Leu Val Thr Val Phe Arg Met Gly Ser Glu Gly Gln 
            340                 345                 350         


Gln Asp Ile Glu Met Ala Ile Leu Thr Ala Leu Leu Lys Gly Thr Asn 
        355                 360                 365             


Val Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp Asn Arg Val 
    370                 375                 380                 


Asp Ile Ala Arg Ser Gln Ile Phe Val Phe Gly Pro His Trp Pro Pro 
385                 390                 395                 400 


Leu Gly Ser Leu Ala Pro Pro Thr Asp Ser Lys Ala Thr Glu Lys Glu 
                405                 410                 415     


Lys Lys Pro Pro Met Ala Thr Thr Lys Gly Gly Arg Gly Lys Gly Lys 
            420                 425                 430         


Gly Lys Lys Lys Gly Lys Val Lys Glu Glu Val Glu Glu Glu Thr Asp 
        435                 440                 445             


Pro Arg Lys Ile Glu Leu Leu Asn Trp Val Asn Ala Leu Glu Gln Ala 
    450                 455                 460                 


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
465                 470                 475                 480 


Ile Glu Asn Gly Val Asn Met Gln His Phe Leu Thr Ile Pro Arg Leu 
                485                 490                 495     


Glu Glu Leu Tyr Asn Thr Arg Leu Gly Pro Pro Asn Thr Leu His Leu 
            500                 505                 510         


Leu Val Arg Asp Val Lys Lys Ser Asn Leu Pro Pro Asp Tyr His Ile 
        515                 520                 525             


Ser Leu Ile Asp Ile Gly Leu Val Leu Glu Tyr Leu Met Gly Gly Ala 
    530                 535                 540                 


Tyr Arg Cys Asn Tyr Thr Arg Lys Asn Phe Arg Thr Leu Tyr Asn Asn 
545                 550                 555                 560 


Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu 
                565                 570                 575     


Asp Asp Glu Pro Pro Ala Lys Gly Lys Lys Lys Lys Lys Lys Lys Lys 
            580                 585                 590         


Glu Glu Glu Ile Asp Ile Asp Val Asp Asp Pro Ala Val Ser Arg Phe 
        595                 600                 605             


Gln Tyr Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg 
    610                 615                 620                 


Gln Lys Met Ala Val Phe Leu Trp Gln Arg Gly Glu Glu Ser Met Ala 
625                 630                 635                 640 


Lys Ala Leu Val Ala Cys Lys Leu Tyr Lys Ala Met Ala His Glu Ser 
                645                 650                 655     


Ser Glu Ser Asp Leu Val Asp Asp Ile Ser Gln Asp Leu Asp Asn Asn 
            660                 665                 670         


Ser Lys Asp Phe Gly Gln Leu Ala Leu Glu Leu Leu Asp Gln Ser Tyr 
        675                 680                 685             


Lys His Asp Glu Gln Ile Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys 
    690                 695                 700                 


Asn Trp Ser Asn Ser Thr Cys Leu Lys Leu Ala Val Ala Ala Lys His 
705                 710                 715                 720 


Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met 
                725                 730                 735     


Trp Met Gly Arg Leu Arg Met Arg Lys Asn Pro Gly Leu Lys Val Ile 
            740                 745                 750         


Met Gly Ile Leu Leu Pro Pro Thr Ile Leu Phe Leu Glu Phe Arg Thr 
        755                 760                 765             


Tyr Asp Asp Phe Ser Tyr Gln Thr Ser Lys Glu Asn Glu Asp Gly Lys 
    770                 775                 780                 


Glu Lys Glu Glu Glu Asn Thr Asp Ala Asn Ala Asp Ala Gly Ser Arg 
785                 790                 795                 800 


Lys Gly Asp Glu Glu Asn Glu His Lys Lys Gln Arg Ser Ile Pro Ile 
                805                 810                 815     


Gly Thr Lys Ile Cys Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp 
            820                 825                 830         


Phe Tyr Thr Ile Ser Tyr Leu Gly Tyr Leu Leu Leu Phe Asn Tyr Val 
        835                 840                 845             


Ile Leu Val Arg Met Asp Gly Trp Pro Ser Leu Gln Glu Trp Ile Val 
    850                 855                 860                 


Ile Ser Tyr Ile Val Ser Leu Ala Leu Glu Lys Ile Arg Glu Ile Leu 
865                 870                 875                 880 


Met Ser Glu Pro Gly Lys Leu Ser Gln Lys Ile Lys Val Trp Leu Gln 
                885                 890                 895     


Glu Tyr Trp Asn Ile Thr Asp Leu Val Ala Ile Ser Thr Phe Met Ile 
            900                 905                 910         


Gly Ala Ile Leu Arg Leu Gln Asn Gln Pro Tyr Met Gly Tyr Gly Arg 
        915                 920                 925             


Val Ile Tyr Cys Val Asp Ile Ile Phe Trp Tyr Ile Arg Val Leu Asp 
    930                 935                 940                 


Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly 
945                 950                 955                 960 


Lys Met Met Ile Asp Met Leu Tyr Phe Val Val Ile Met Leu Val Val 
                965                 970                 975     


Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu His Pro Glu Glu 
            980                 985                 990         


Lys Pro Ser Trp Lys Leu Ala Arg  Asn Ile Phe Tyr Met  Pro Tyr Trp 
        995                 1000                 1005             


Met Ile  Tyr Gly Glu Val Phe  Ala Asp Gln Ile Asp  Leu Tyr Ala 
    1010                 1015                 1020             


Met Glu  Ile Asn Pro Pro Cys  Gly Glu Asn Leu Tyr  Asp Glu Glu 
    1025                 1030                 1035             


Gly Lys  Arg Leu Pro Pro Cys  Ile Pro Gly Ala Trp  Leu Thr Pro 
    1040                 1045                 1050             


Ala Leu  Met Ala Cys Tyr Leu  Leu Val Ala Asn Ile  Leu Leu Val 
    1055                 1060                 1065             


Asn Leu  Leu Ile Ala Val Phe  Asn Asn Thr Phe Phe  Glu Val Lys 
    1070                 1075                 1080             


Ser Ile  Ser Asn Gln Val Trp  Lys Phe Gln Arg Tyr  Gln Leu Ile 
    1085                 1090                 1095             


Met Thr  Phe His Asp Arg Pro  Val Leu Pro Pro Pro  Met Ile Ile 
    1100                 1105                 1110             


Leu Ser  His Ile Tyr Ile Ile  Ile Met Arg Leu Ser  Gly Arg Cys 
    1115                 1120                 1125             


Arg Lys  Lys Arg Glu Gly Asp  Gln Glu Glu Arg Asp  Arg Gly Leu 
    1130                 1135                 1140             


Lys Leu  Phe Leu Ser Asp Glu  Glu Leu Lys Arg Leu  His Glu Phe 
    1145                 1150                 1155             


Glu Glu  Gln Cys Val Gln Glu  His Phe Arg Glu Lys  Glu Asp Glu 
    1160                 1165                 1170             


Gln Gln  Ser Ser Ser Asp Glu  Arg Ile Arg Val Thr  Ser Glu Arg 
    1175                 1180                 1185             


Val Glu  Asn Met Ser Met Arg  Leu Glu Glu Ile Asn  Glu Arg Glu 
    1190                 1195                 1200             


Thr Phe  Met Lys Thr Ser Leu  Gln Thr Val Asp Leu  Arg Leu Ala 
    1205                 1210                 1215             


Gln Leu  Glu Glu Leu Ser Asn  Arg Met Val Asn Ala  Leu Glu Asn 
    1220                 1225                 1230             


Leu Ala  Gly Ile Asp Arg Ser  Asp Leu Ile Gln Ala  Arg Ser Arg 
    1235                 1240                 1245             


Ala Ser  Ser Glu Cys Glu Ala  Thr Tyr Leu Leu Arg  Gln Ser Ser 
    1250                 1255                 1260             


Ile Asn  Ser Ala Asp Gly Tyr  Ser Leu Tyr Arg Tyr  His Phe Asn 
    1265                 1270                 1275             


Gly Glu  Glu Leu Leu Phe Glu  Asp Thr Ser Leu Ser  Thr Ser Pro 
    1280                 1285                 1290             


Gly Thr  Gly Val Arg Lys Lys  Thr Cys Ser Phe Arg  Ile Lys Glu 
    1295                 1300                 1305             


Glu Lys  Asp Val Lys Thr His  Leu Val Pro Glu Cys  Gln Asn Ser 
    1310                 1315                 1320             


Leu His  Leu Ser Leu Gly Thr  Ser Thr Ser Ala Thr  Pro Asp Gly 
    1325                 1330                 1335             


Ser His  Leu Ala Val Asp Asp  Leu Lys Asn Ala Glu  Glu Ser Lys 
    1340                 1345                 1350             


Leu Gly  Pro Asp Ile Gly Ile  Ser Lys Glu Asp Asp  Glu Arg Gln 
    1355                 1360                 1365             


Thr Asp  Ser Lys Lys Glu Glu  Thr Ile Ser Pro Ser  Leu Asn Lys 
    1370                 1375                 1380             


Thr Asp  Val Ile His Gly Gln  Asp Lys Ser Asp Val  Gln Asn Thr 
    1385                 1390                 1395             


Gln Leu  Thr Val Glu Thr Thr  Asn Ile Glu Gly Thr  Ile Ser Tyr 
    1400                 1405                 1410             


Pro Leu  Glu Glu Thr Lys Ile  Thr Arg Tyr Phe Pro  Asp Glu Thr 
    1415                 1420                 1425             


Ile Asn  Ala Cys Lys Thr Met  Lys Ser Arg Ser Phe  Val Tyr Ser 
    1430                 1435                 1440             


Arg Gly  Arg Lys Leu Val Gly  Gly Val Asn Gln Asp  Val Glu Tyr 
    1445                 1450                 1455             


Ser Ser  Ile Thr Asp Gln Gln  Leu Thr Thr Glu Trp  Gln Cys Gln 
    1460                 1465                 1470             


Val Gln  Lys Ile Thr Arg Ser  His Ser Thr Asp Ile  Pro Tyr Ile 
    1475                 1480                 1485             


Val Ser  Glu Ala Ala Val Gln  Ala Glu His Lys Glu  Gln Phe Ala 
    1490                 1495                 1500             


Asp Met  Gln Asp Glu His His  Val Ala Glu Ala Ile  Pro Arg Ile 
    1505                 1510                 1515             


Pro Arg  Leu Ser Leu Thr Ile  Thr Asp Arg Asn Gly  Met Glu Asn 
    1520                 1525                 1530             


Leu Leu  Ser Val Lys Pro Asp  Gln Thr Leu Gly Phe  Pro Ser Leu 
    1535                 1540                 1545             


Arg Ser  Lys Ser Leu His Gly  His Pro Arg Asn Val  Lys Ser Ile 
    1550                 1555                 1560             


Gln Gly  Lys Leu Asp Arg Ser  Gly His Ala Ser Ser  Val Ser Ser 
    1565                 1570                 1575             


Leu Val  Ile Val Ser Gly Met  Thr Ala Glu Glu Lys  Lys Val Lys 
    1580                 1585                 1590             


Lys Glu  Lys Ala Ser Thr Glu  Thr Glu Cys 
    1595                 1600             


<210>  15
<211>  1556
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Arg Glu Tyr Pro Gly Phe Gly Trp Ile 
385                 390                 395                 400 


Tyr Phe Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp 
                405                 410                 415     


Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn 
            420                 425                 430         


Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro 
        435                 440                 445             


Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys 
    450                 455                 460                 


Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His 
465                 470                 475                 480 


Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys 
                485                 490                 495     


Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met 
            500                 505                 510         


Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu 
        515                 520                 525             


Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His 
    530                 535                 540                 


Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser 
545                 550                 555                 560 


Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu 
                565                 570                 575     


Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys 
            580                 585                 590         


His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp 
        595                 600                 605             


Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val 
    610                 615                 620                 


Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys 
625                 630                 635                 640 


Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu 
                645                 650                 655     


Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu 
            660                 665                 670         


Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu 
        675                 680                 685             


Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu 
    690                 695                 700                 


Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val 
705                 710                 715                 720 


Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe 
                725                 730                 735     


Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu 
            740                 745                 750         


Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg 
        755                 760                 765             


Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val 
    770                 775                 780                 


Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu 
785                 790                 795                 800 


Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser 
                805                 810                 815     


Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg 
            820                 825                 830         


Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met 
        835                 840                 845             


Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met 
    850                 855                 860                 


Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe 
865                 870                 875                 880 


Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met 
                885                 890                 895     


Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro 
            900                 905                 910         


Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu 
        915                 920                 925             


Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys 
    930                 935                 940                 


Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val 
945                 950                 955                 960 


Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp 
                965                 970                 975     


Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val 
            980                 985                 990         


Leu Pro Pro Pro Leu Ile Ile Phe  Ser His Met Thr Met  Ile Phe Gln 
        995                 1000                 1005             


His Leu  Cys Cys Arg Trp Arg  Lys His Glu Ser Asp  Pro Asp Glu 
    1010                 1015                 1020             


Arg Asp  Tyr Gly Leu Lys Leu  Phe Ile Thr Asp Asp  Glu Leu Lys 
    1025                 1030                 1035             


Lys Val  His Asp Phe Glu Glu  Gln Cys Ile Glu Glu  Tyr Phe Arg 
    1040                 1045                 1050             


Glu Lys  Asp Asp Arg Phe Asn  Ser Ser Asn Asp Glu  Arg Ile Arg 
    1055                 1060                 1065             


Val Thr  Ser Glu Arg Val Glu  Asn Met Ser Met Arg  Leu Glu Glu 
    1070                 1075                 1080             


Val Asn  Glu Arg Glu His Ser  Met Lys Ala Ser Leu  Gln Thr Val 
    1085                 1090                 1095             


Asp Ile  Arg Leu Ala Gln Leu  Glu Asp Leu Ile Gly  Arg Met Ala 
    1100                 1105                 1110             


Thr Ala  Leu Glu Arg Leu Thr  Gly Leu Glu Arg Ala  Glu Ser Asn 
    1115                 1120                 1125             


Lys Ile  Arg Ser Arg Thr Ser  Ser Asp Cys Thr Asp  Ala Ala Tyr 
    1130                 1135                 1140             


Ile Val  Arg Gln Ser Ser Phe  Asn Ser Gln Glu Gly  Asn Thr Phe 
    1145                 1150                 1155             


Lys Leu  Gln Glu Ser Ile Asp  Pro Ala Gly Glu Glu  Thr Met Ser 
    1160                 1165                 1170             


Pro Thr  Ser Pro Thr Leu Met  Pro Arg Met Arg Ser  His Ser Phe 
    1175                 1180                 1185             


Tyr Ser  Val Asn Met Lys Asp  Lys Gly Gly Ile Glu  Lys Leu Glu 
    1190                 1195                 1200             


Ser Ile  Phe Lys Glu Arg Ser  Leu Ser Leu His Arg  Ala Thr Ser 
    1205                 1210                 1215             


Ser His  Ser Val Ala Lys Glu  Pro Lys Ala Pro Ala  Ala Pro Ala 
    1220                 1225                 1230             


Asn Thr  Leu Ala Ile Val Pro  Asp Ser Arg Arg Pro  Ser Ser Cys 
    1235                 1240                 1245             


Ile Asp  Ile Tyr Val Ser Ala  Met Asp Glu Leu His  Cys Asp Ile 
    1250                 1255                 1260             


Asp Pro  Leu Asp Asn Ser Val  Asn Ile Leu Gly Leu  Gly Glu Pro 
    1265                 1270                 1275             


Ser Phe  Ser Thr Pro Val Pro  Ser Thr Ala Pro Ser  Ser Ser Ala 
    1280                 1285                 1290             


Tyr Ala  Thr Leu Ala Pro Thr  Asp Arg Pro Pro Ser  Arg Ser Ile 
    1295                 1300                 1305             


Asp Phe  Glu Asp Ile Thr Ser  Met Asp Thr Arg Ser  Phe Ser Ser 
    1310                 1315                 1320             


Asp Tyr  Thr His Leu Pro Glu  Cys Gln Asn Pro Trp  Asp Ser Glu 
    1325                 1330                 1335             


Pro Pro  Met Tyr His Thr Ile  Glu Arg Ser Lys Ser  Ser Arg Tyr 
    1340                 1345                 1350             


Leu Ala  Thr Thr Pro Phe Leu  Leu Glu Glu Ala Pro  Ile Val Lys 
    1355                 1360                 1365             


Ser His  Ser Phe Met Phe Ser  Pro Ser Arg Ser Tyr  Tyr Ala Asn 
    1370                 1375                 1380             


Phe Gly  Val Pro Val Lys Thr  Ala Glu Tyr Thr Ser  Ile Thr Asp 
    1385                 1390                 1395             


Cys Ile  Asp Thr Arg Cys Val  Asn Ala Pro Gln Ala  Ile Ala Asp 
    1400                 1405                 1410             


Arg Ala  Ala Phe Pro Gly Gly  Leu Gly Asp Lys Val  Glu Asp Leu 
    1415                 1420                 1425             


Thr Cys  Cys His Pro Glu Arg  Glu Ala Glu Leu Ser  His Pro Ser 
    1430                 1435                 1440             


Ser Asp  Ser Glu Glu Asn Glu  Ala Lys Gly Arg Arg  Ala Thr Ile 
    1445                 1450                 1455             


Ala Ile  Ser Ser Gln Glu Gly  Asp Asn Ser Glu Arg  Thr Leu Ser 
    1460                 1465                 1470             


Asn Asn  Ile Thr Val Pro Lys  Ile Glu Arg Ala Asn  Ser Tyr Ser 
    1475                 1480                 1485             


Ala Glu  Glu Pro Ser Ala Pro  Tyr Ala His Thr Arg  Lys Ser Phe 
    1490                 1495                 1500             


Ser Ile  Ser Asp Lys Leu Asp  Arg Gln Arg Asn Thr  Ala Ser Leu 
    1505                 1510                 1515             


Arg Asn  Pro Phe Gln Arg Ser  Lys Ser Ser Lys Pro  Glu Gly Arg 
    1520                 1525                 1530             


Gly Asp  Ser Leu Ser Met Arg  Arg Leu Ser Arg Thr  Ser Ala Phe 
    1535                 1540                 1545             


Gln Ser  Phe Glu Ser Lys His  Asn 
    1550                 1555     


<210>  16
<211>  2022
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Glu Gln Pro Val Leu Glu Arg Leu Gln Ser Gln Lys Ser Trp 
1               5                   10                  15      


Ile Lys Gly Val Phe Asp Lys Arg Glu Cys Ser Thr Ile Ile Pro Ser 
            20                  25                  30          


Ser Lys Asn Pro His Arg Cys Thr Pro Val Cys Gln Val Cys Gln Asn 
        35                  40                  45              


Leu Ile Arg Cys Tyr Cys Gly Arg Leu Ile Gly Asp His Ala Gly Ile 
    50                  55                  60                  


Asp Tyr Ser Trp Thr Ile Ser Ala Ala Lys Gly Lys Glu Ser Glu Gln 
65                  70                  75                  80  


Trp Ser Val Glu Lys His Thr Thr Lys Ser Pro Thr Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Asn Phe Gln Asp Gly Glu His Thr His His Ala Lys Tyr Ile 
            100                 105                 110         


Arg Thr Ser Tyr Asp Thr Lys Leu Asp His Leu Leu His Leu Met Leu 
        115                 120                 125             


Lys Glu Trp Lys Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly 
    130                 135                 140                 


Gly Ile Gln Asn Phe Thr Met Pro Ser Lys Phe Lys Glu Ile Phe Ser 
145                 150                 155                 160 


Gln Gly Leu Val Lys Ala Ala Glu Thr Thr Gly Ala Trp Ile Ile Thr 
                165                 170                 175     


Glu Gly Ile Asn Thr Gly Val Ser Lys His Val Gly Asp Ala Leu Lys 
            180                 185                 190         


Ser His Ser Ser His Ser Leu Arg Lys Ile Trp Thr Val Gly Ile Pro 
        195                 200                 205             


Pro Trp Gly Val Ile Glu Asn Gln Arg Asp Leu Ile Gly Lys Asp Val 
    210                 215                 220                 


Val Cys Leu Tyr Gln Thr Leu Asp Asn Pro Leu Ser Lys Leu Thr Thr 
225                 230                 235                 240 


Leu Asn Ser Met His Ser His Phe Ile Leu Ser Asp Asp Gly Thr Val 
                245                 250                 255     


Gly Lys Tyr Gly Asn Glu Met Lys Leu Arg Arg Asn Leu Glu Lys Tyr 
            260                 265                 270         


Leu Ser Leu Gln Lys Ile His Cys Arg Ser Arg Gln Gly Val Pro Val 
        275                 280                 285             


Val Gly Leu Val Val Glu Gly Gly Pro Asn Val Ile Leu Ser Val Trp 
    290                 295                 300                 


Glu Thr Val Lys Asp Lys Asp Pro Val Val Val Cys Glu Gly Thr Gly 
305                 310                 315                 320 


Arg Ala Ala Asp Leu Leu Ala Phe Thr His Lys His Leu Ala Asp Glu 
                325                 330                 335     


Gly Met Leu Arg Pro Gln Val Lys Glu Glu Ile Ile Cys Met Ile Gln 
            340                 345                 350         


Asn Thr Phe Asn Phe Ser Leu Lys Gln Ser Lys His Leu Phe Gln Ile 
        355                 360                 365             


Leu Met Glu Cys Met Val His Arg Asp Cys Ile Thr Ile Phe Asp Ala 
    370                 375                 380                 


Asp Ser Glu Glu Gln Gln Asp Leu Asp Leu Ala Ile Leu Thr Ala Leu 
385                 390                 395                 400 


Leu Lys Gly Thr Asn Leu Ser Ala Ser Glu Gln Leu Asn Leu Ala Met 
                405                 410                 415     


Ala Trp Asp Arg Val Asp Ile Ala Lys Lys His Ile Leu Ile Tyr Glu 
            420                 425                 430         


Gln His Trp Lys Pro Asp Ala Leu Glu Gln Ala Met Ser Asp Ala Leu 
        435                 440                 445             


Val Met Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Tyr Gly Val 
    450                 455                 460                 


Asn Leu His Arg Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn 
465                 470                 475                 480 


Thr Lys Gln Gly Pro Thr Asn Thr Leu Leu His His Leu Val Gln Asp 
                485                 490                 495     


Val Lys Gln His Thr Leu Leu Ser Gly Tyr Arg Ile Thr Leu Ile Asp 
            500                 505                 510         


Ile Gly Leu Val Val Glu Tyr Leu Ile Gly Arg Ala Tyr Arg Ser Asn 
        515                 520                 525             


Tyr Thr Arg Lys His Phe Arg Ala Leu Tyr Asn Asn Leu Tyr Arg Lys 
    530                 535                 540                 


Tyr Lys His Gln Arg His Ser Ser Gly Asn Arg Asn Glu Ser Ala Glu 
545                 550                 555                 560 


Ser Thr Leu His Ser Gln Phe Ile Arg Thr Ala Gln Pro Tyr Lys Phe 
                565                 570                 575     


Lys Glu Lys Ser Ile Val Leu His Lys Ser Arg Lys Lys Ser Lys Glu 
            580                 585                 590         


Gln Asn Val Ser Asp Asp Pro Glu Ser Thr Gly Phe Leu Tyr Pro Tyr 
        595                 600                 605             


Asn Asp Leu Leu Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala 
    610                 615                 620                 


Met Phe Phe Trp Gln His Gly Glu Glu Ala Thr Val Lys Ala Val Ile 
625                 630                 635                 640 


Ala Cys Ile Leu Tyr Arg Ala Met Ala His Glu Ala Lys Glu Ser His 
                645                 650                 655     


Met Val Asp Asp Ala Ser Glu Glu Leu Lys Asn Tyr Ser Lys Gln Phe 
            660                 665                 670         


Gly Gln Leu Ala Leu Asp Leu Leu Glu Lys Ala Phe Lys Gln Asn Glu 
        675                 680                 685             


Arg Met Ala Met Thr Leu Leu Thr Tyr Glu Leu Arg Asn Trp Ser Asn 
    690                 695                 700                 


Ser Thr Cys Leu Lys Leu Ala Val Ser Gly Gly Leu Arg Pro Phe Val 
705                 710                 715                 720 


Ser His Thr Cys Thr Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg 
                725                 730                 735     


Leu Lys Met Arg Lys Asn Ser Trp Leu Lys Ile Ile Ile Ser Ile Ile 
            740                 745                 750         


Leu Pro Pro Thr Ile Leu Thr Leu Glu Phe Lys Ser Lys Ala Glu Met 
        755                 760                 765             


Ser His Val Pro Gln Ser Gln Asp Phe Gln Phe Met Trp Tyr Tyr Ser 
    770                 775                 780                 


Asp Gln Asn Ala Ser Ser Ser Lys Glu Ser Ala Ser Val Lys Glu Tyr 
785                 790                 795                 800 


Asp Leu Glu Arg Gly His Asp Glu Lys Leu Asp Glu Asn Gln His Phe 
                805                 810                 815     


Gly Leu Glu Ser Gly His Gln His Leu Pro Trp Thr Arg Lys Val Tyr 
            820                 825                 830         


Glu Phe Tyr Ser Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Met Ala 
        835                 840                 845             


Tyr Leu Ala Phe Leu Met Leu Phe Thr Tyr Thr Val Leu Val Glu Met 
    850                 855                 860                 


Gln Pro Gln Pro Ser Val Gln Glu Trp Leu Val Ser Ile Tyr Ile Phe 
865                 870                 875                 880 


Thr Asn Ala Ile Glu Val Val Arg Glu Ile Cys Ile Ser Glu Pro Gly 
                885                 890                 895     


Lys Phe Thr Gln Lys Val Lys Val Trp Ile Ser Glu Tyr Trp Asn Leu 
            900                 905                 910         


Thr Glu Thr Val Ala Ile Gly Leu Phe Ser Ala Gly Phe Val Leu Arg 
        915                 920                 925             


Trp Gly Asp Pro Pro Phe His Thr Ala Gly Arg Leu Ile Tyr Cys Ile 
    930                 935                 940                 


Asp Ile Ile Phe Trp Phe Ser Arg Leu Leu Asp Phe Phe Ala Val Asn 
945                 950                 955                 960 


Gln His Ala Gly Pro Tyr Val Thr Met Ile Ala Lys Met Thr Ala Asn 
                965                 970                 975     


Met Phe Tyr Ile Val Ile Ile Met Ala Ile Val Leu Leu Ser Phe Gly 
            980                 985                 990         


Val Ala Arg Lys Ala Ile Leu Ser  Pro Lys Glu Pro Pro  Ser Trp Ser 
        995                 1000                 1005             


Leu Ala  Arg Asp Ile Val Phe  Glu Pro Tyr Trp Met  Ile Tyr Gly 
    1010                 1015                 1020             


Glu Val  Tyr Ala Gly Glu Ile  Asp Val Cys Ser Ser  Gln Pro Ser 
    1025                 1030                 1035             


Cys Pro  Pro Gly Ser Phe Leu  Thr Pro Phe Leu Gln  Ala Val Tyr 
    1040                 1045                 1050             


Leu Phe  Val Gln Tyr Ile Ile  Met Val Asn Leu Leu  Ile Ala Phe 
    1055                 1060                 1065             


Phe Asn  Asn Val Tyr Leu Asp  Met Glu Ser Ile Ser  Asn Asn Leu 
    1070                 1075                 1080             


Trp Lys  Tyr Asn Arg Tyr Arg  Tyr Ile Met Thr Tyr  His Glu Lys 
    1085                 1090                 1095             


Pro Trp  Leu Pro Pro Pro Leu  Ile Leu Leu Ser His  Val Gly Leu 
    1100                 1105                 1110             


Leu Leu  Arg Arg Leu Cys Cys  His Arg Ala Pro His  Asp Gln Glu 
    1115                 1120                 1125             


Glu Gly  Asp Val Gly Leu Lys  Leu Tyr Leu Ser Lys  Glu Asp Leu 
    1130                 1135                 1140             


Lys Lys  Leu His Asp Phe Glu  Glu Gln Cys Val Glu  Lys Tyr Phe 
    1145                 1150                 1155             


His Glu  Lys Met Glu Asp Val  Asn Cys Ser Cys Glu  Glu Arg Ile 
    1160                 1165                 1170             


Arg Val  Thr Ser Glu Arg Val  Thr Glu Met Tyr Phe  Gln Leu Lys 
    1175                 1180                 1185             


Glu Met  Asn Glu Lys Val Ser  Phe Ile Lys Asp Ser  Leu Leu Ser 
    1190                 1195                 1200             


Leu Asp  Ser Gln Val Gly His  Leu Gln Asp Leu Ser  Ala Leu Thr 
    1205                 1210                 1215             


Val Asp  Thr Leu Lys Val Leu  Ser Ala Val Asp Thr  Leu Gln Glu 
    1220                 1225                 1230             


Asp Glu  Ala Leu Leu Ala Lys  Arg Lys His Ser Thr  Cys Lys Lys 
    1235                 1240                 1245             


Leu Pro  His Ser Trp Ser Asn  Val Ile Cys Ala Glu  Val Leu Gly 
    1250                 1255                 1260             


Ser Met  Glu Ile Ala Gly Glu  Lys Lys Tyr Gln Tyr  Tyr Ser Met 
    1265                 1270                 1275             


Pro Ser  Ser Leu Leu Arg Ser  Leu Ala Gly Gly Arg  His Pro Pro 
    1280                 1285                 1290             


Arg Val  Gln Arg Gly Ala Leu  Leu Glu Ile Thr Asn  Ser Lys Arg 
    1295                 1300                 1305             


Glu Ala  Thr Asn Val Arg Asn  Asp Gln Glu Arg Gln  Glu Thr Gln 
    1310                 1315                 1320             


Ser Ser  Ile Val Val Ser Gly  Val Ser Pro Asn Arg  Gln Ala His 
    1325                 1330                 1335             


Ser Lys  Tyr Gly Gln Phe Leu  Leu Val Pro Ser Asn  Leu Lys Arg 
    1340                 1345                 1350             


Val Pro  Phe Ser Ala Glu Thr  Val Leu Pro Leu Ser  Arg Pro Ser 
    1355                 1360                 1365             


Val Pro  Asp Val Leu Ala Thr  Glu Gln Asp Ile Gln  Thr Glu Val 
    1370                 1375                 1380             


Leu Val  His Leu Thr Gly Gln  Thr Pro Val Val Ser  Asp Trp Ala 
    1385                 1390                 1395             


Ser Val  Asp Glu Pro Lys Glu  Lys His Glu Pro Ile  Ala His Leu 
    1400                 1405                 1410             


Leu Asp  Gly Gln Asp Lys Ala  Glu Gln Val Leu Pro  Thr Leu Ser 
    1415                 1420                 1425             


Cys Thr  Pro Glu Pro Met Thr  Met Ser Ser Pro Leu  Ser Gln Ala 
    1430                 1435                 1440             


Lys Ile  Met Gln Thr Gly Gly  Gly Tyr Val Asn Trp  Ala Phe Ser 
    1445                 1450                 1455             


Glu Gly  Asp Glu Thr Gly Val  Phe Ser Ile Lys Lys  Lys Trp Gln 
    1460                 1465                 1470             


Thr Cys  Leu Pro Ser Thr Cys  Asp Ser Asp Ser Ser  Arg Ser Glu 
    1475                 1480                 1485             


Gln His  Gln Lys Gln Ala Gln  Asp Ser Ser Leu Ser  Asp Asn Ser 
    1490                 1495                 1500             


Thr Arg  Ser Ala Gln Ser Ser  Glu Cys Ser Glu Val  Gly Pro Trp 
    1505                 1510                 1515             


Leu Gln  Pro Asn Thr Ser Phe  Trp Ile Asn Pro Leu  Arg Arg Tyr 
    1520                 1525                 1530             


Arg Pro  Phe Ala Arg Ser His  Ser Phe Arg Phe His  Lys Glu Glu 
    1535                 1540                 1545             


Lys Leu  Met Lys Ile Cys Lys  Ile Lys Asn Leu Ser  Gly Ser Ser 
    1550                 1555                 1560             


Glu Ile  Gly Gln Gly Ala Trp  Val Lys Ala Lys Met  Leu Thr Lys 
    1565                 1570                 1575             


Asp Arg  Arg Leu Ser Lys Lys  Lys Lys Asn Thr Gln  Gly Leu Gln 
    1580                 1585                 1590             


Val Pro  Ile Ile Thr Val Asn  Ala Cys Ser Gln Ser  Asp Gln Leu 
    1595                 1600                 1605             


Asn Pro  Glu Pro Gly Glu Asn  Ser Ile Ser Glu Glu  Glu Tyr Ser 
    1610                 1615                 1620             


Lys Asn  Trp Phe Thr Val Ser  Lys Phe Ser His Thr  Gly Val Glu 
    1625                 1630                 1635             


Pro Tyr  Ile His Gln Lys Met  Lys Thr Lys Glu Ile  Gly Gln Cys 
    1640                 1645                 1650             


Ala Ile  Gln Ile Ser Asp Tyr  Leu Lys Gln Ser Gln  Glu Asp Leu 
    1655                 1660                 1665             


Ser Lys  Asn Ser Leu Trp Asn  Ser Arg Ser Thr Asn  Leu Asn Arg 
    1670                 1675                 1680             


Asn Ser  Leu Leu Lys Ser Ser  Ile Gly Val Asp Lys  Ile Ser Ala 
    1685                 1690                 1695             


Ser Leu  Lys Ser Pro Gln Glu  Pro His His His Tyr  Ser Ala Ile 
    1700                 1705                 1710             


Glu Arg  Asn Asn Leu Met Arg  Leu Ser Gln Thr Ile  Pro Phe Thr 
    1715                 1720                 1725             


Pro Val  Gln Leu Phe Ala Gly  Glu Glu Ile Thr Val  Tyr Arg Leu 
    1730                 1735                 1740             


Glu Glu  Ser Ser Pro Leu Asn  Leu Asp Lys Ser Met  Ser Ser Trp 
    1745                 1750                 1755             


Ser Gln  Arg Gly Arg Ala Ala  Met Ile Gln Val Leu  Ser Arg Glu 
    1760                 1765                 1770             


Glu Met  Asp Gly Gly Leu Arg  Lys Ala Met Arg Val  Val Ser Thr 
    1775                 1780                 1785             


Trp Ser  Glu Asp Asp Ile Leu  Lys Pro Gly Gln Val  Phe Ile Val 
    1790                 1795                 1800             


Lys Ser  Phe Leu Pro Glu Val  Val Arg Thr Trp His  Lys Ile Phe 
    1805                 1810                 1815             


Gln Glu  Ser Thr Val Leu His  Leu Cys Leu Arg Glu  Ile Gln Gln 
    1820                 1825                 1830             


Gln Arg  Ala Ala Gln Lys Leu  Ile Tyr Thr Phe Asn  Gln Val Lys 
    1835                 1840                 1845             


Pro Gln  Thr Ile Pro Tyr Thr  Pro Arg Phe Leu Glu  Val Phe Leu 
    1850                 1855                 1860             


Ile Tyr  Cys His Ser Ala Asn  Gln Trp Leu Thr Ile  Glu Lys Tyr 
    1865                 1870                 1875             


Met Thr  Gly Glu Phe Arg Lys  Tyr Asn Asn Asn Asn  Gly Asp Glu 
    1880                 1885                 1890             


Ile Thr  Pro Thr Asn Thr Leu  Glu Glu Leu Met Leu  Ala Phe Ser 
    1895                 1900                 1905             


His Trp  Thr Tyr Glu Tyr Thr  Arg Gly Glu Leu Leu  Val Leu Asp 
    1910                 1915                 1920             


Leu Gln  Gly Val Gly Glu Asn  Leu Thr Asp Pro Ser  Val Ile Lys 
    1925                 1930                 1935             


Pro Glu  Val Lys Gln Ser Arg  Gly Met Val Phe Gly  Pro Ala Asn 
    1940                 1945                 1950             


Leu Gly  Glu Asp Ala Ile Arg  Asn Phe Ile Ala Lys  His His Cys 
    1955                 1960                 1965             


Asn Ser  Cys Cys Arg Lys Leu  Lys Leu Pro Asp Leu  Lys Arg Asn 
    1970                 1975                 1980             


Asp Tyr  Ser Pro Glu Arg Ile  Asn Ser Thr Phe Gly  Leu Glu Ile 
    1985                 1990                 1995             


Lys Ile  Glu Ser Ala Glu Glu  Pro Pro Ala Arg Glu  Thr Gly Arg 
    2000                 2005                 2010             


Asn Ser  Pro Glu Asp Asp Met  Gln Leu 
    2015                 2020         


<210>  17
<211>  1865
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Gln Lys Ser Trp Ile Glu Ser Thr Leu Thr Lys Arg Glu Cys 
1               5                   10                  15      


Val Tyr Ile Ile Pro Ser Ser Lys Asp Pro His Arg Cys Leu Pro Gly 
            20                  25                  30          


Cys Gln Ile Cys Gln Gln Leu Val Arg Cys Phe Cys Gly Arg Leu Val 
        35                  40                  45              


Lys Gln His Ala Cys Phe Thr Ala Ser Leu Ala Met Lys Tyr Ser Asp 
    50                  55                  60                  


Val Lys Leu Gly Asp His Phe Asn Gln Ala Ile Glu Glu Trp Ser Val 
65                  70                  75                  80  


Glu Lys His Thr Glu Gln Ser Pro Thr Asp Ala Tyr Gly Val Ile Asn 
                85                  90                  95      


Phe Gln Gly Gly Ser His Ser Tyr Arg Ala Lys Tyr Val Arg Leu Ser 
            100                 105                 110         


Tyr Asp Thr Lys Pro Glu Val Ile Leu Gln Leu Leu Leu Lys Glu Trp 
        115                 120                 125             


Gln Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly Gly Met Gln 
    130                 135                 140                 


Lys Phe Glu Leu His Pro Arg Ile Lys Gln Leu Leu Gly Lys Gly Leu 
145                 150                 155                 160 


Ile Lys Ala Ala Val Thr Thr Gly Ala Trp Ile Leu Thr Gly Gly Val 
                165                 170                 175     


Asn Thr Gly Val Ala Lys His Val Gly Asp Ala Leu Lys Glu His Ala 
            180                 185                 190         


Ser Arg Ser Ser Arg Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly 
        195                 200                 205             


Val Ile Glu Asn Arg Asn Asp Leu Val Gly Arg Asp Val Val Ala Pro 
    210                 215                 220                 


Tyr Gln Thr Leu Leu Asn Pro Leu Ser Lys Leu Asn Val Leu Asn Asn 
225                 230                 235                 240 


Leu His Ser His Phe Ile Leu Val Asp Asp Gly Thr Val Gly Lys Tyr 
                245                 250                 255     


Gly Ala Glu Val Arg Leu Arg Arg Glu Leu Glu Lys Thr Ile Asn Gln 
            260                 265                 270         


Gln Arg Ile His Ala Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu 
        275                 280                 285             


Ile Phe Glu Gly Gly Pro Asn Val Ile Leu Thr Val Leu Glu Tyr Leu 
    290                 295                 300                 


Gln Glu Ser Pro Pro Val Pro Val Val Val Cys Glu Gly Thr Gly Arg 
305                 310                 315                 320 


Ala Ala Asp Leu Leu Ala Tyr Ile His Lys Gln Thr Glu Glu Gly Gly 
                325                 330                 335     


Asn Leu Pro Asp Ala Ala Glu Pro Asp Ile Ile Ser Thr Ile Lys Lys 
            340                 345                 350         


Thr Phe Asn Phe Gly Gln Asn Glu Ala Leu His Leu Phe Gln Thr Leu 
        355                 360                 365             


Met Glu Cys Met Lys Arg Lys Glu Leu Ile Thr Val Phe His Ile Gly 
    370                 375                 380                 


Ser Asp Glu His Gln Asp Ile Asp Val Ala Ile Leu Thr Ala Leu Leu 
385                 390                 395                 400 


Lys Gly Thr Asn Ala Ser Ala Phe Asp Gln Leu Ile Leu Thr Leu Ala 
                405                 410                 415     


Trp Asp Arg Val Asp Ile Ala Lys Asn His Val Phe Val Tyr Gly Gln 
            420                 425                 430         


Gln Trp Leu Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val 
        435                 440                 445             


Met Asp Arg Val Ala Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser 
    450                 455                 460                 


Met His Lys Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr 
465                 470                 475                 480 


Lys Gln Gly Pro Thr Asn Pro Met Leu Phe His Leu Val Arg Asp Val 
                485                 490                 495     


Lys Gln Gly Asn Leu Pro Pro Gly Tyr Lys Ile Thr Leu Ile Asp Ile 
            500                 505                 510         


Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Thr Tyr Arg Cys Thr Tyr 
        515                 520                 525             


Thr Arg Lys Arg Phe Arg Leu Ile Tyr Asn Ser Leu Gly Gly Asn Asn 
    530                 535                 540                 


Arg Arg Ser Gly Arg Asn Thr Ser Ser Ser Thr Pro Gln Leu Arg Lys 
545                 550                 555                 560 


Ser His Glu Ser Phe Gly Asn Arg Ala Asp Lys Lys Glu Lys Met Arg 
                565                 570                 575     


His Asn His Phe Ile Lys Thr Ala Gln Pro Tyr Arg Pro Lys Ile Asp 
            580                 585                 590         


Thr Val Met Glu Glu Gly Lys Lys Lys Arg Thr Lys Asp Glu Ile Val 
        595                 600                 605             


Asp Ile Asp Asp Pro Glu Thr Lys Arg Phe Pro Tyr Pro Leu Asn Glu 
    610                 615                 620                 


Leu Leu Ile Trp Ala Cys Leu Met Lys Arg Gln Val Met Ala Arg Phe 
625                 630                 635                 640 


Leu Trp Gln His Gly Glu Glu Ser Met Ala Lys Ala Leu Val Ala Cys 
                645                 650                 655     


Lys Ile Tyr Arg Ser Met Ala Tyr Glu Ala Lys Gln Ser Asp Leu Val 
            660                 665                 670         


Asp Asp Thr Ser Glu Glu Leu Lys Gln Tyr Ser Asn Asp Phe Gly Gln 
        675                 680                 685             


Leu Ala Val Glu Leu Leu Glu Gln Ser Phe Arg Gln Asp Glu Thr Met 
    690                 695                 700                 


Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ser Thr 
705                 710                 715                 720 


Cys Leu Lys Leu Ala Val Ser Ser Arg Leu Arg Pro Phe Val Ala His 
                725                 730                 735     


Thr Cys Thr Gln Met Leu Leu Ser Asp Met Trp Met Gly Arg Leu Asn 
            740                 745                 750         


Met Arg Lys Asn Ser Trp Tyr Lys Val Ile Leu Ser Ile Leu Val Pro 
        755                 760                 765             


Pro Ala Ile Leu Leu Leu Glu Tyr Lys Thr Lys Ala Glu Met Ser His 
    770                 775                 780                 


Ile Pro Gln Ser Gln Asp Ala His Gln Met Thr Met Asp Asp Ser Glu 
785                 790                 795                 800 


Asn Asn Phe Gln Asn Ile Thr Glu Glu Ile Pro Met Glu Val Phe Lys 
                805                 810                 815     


Glu Val Arg Ile Leu Asp Ser Asn Glu Gly Lys Asn Glu Met Glu Ile 
            820                 825                 830         


Gln Met Lys Ser Lys Lys Leu Pro Ile Thr Arg Lys Phe Tyr Ala Phe 
        835                 840                 845             


Tyr His Ala Pro Ile Val Lys Phe Trp Phe Asn Thr Leu Ala Tyr Leu 
    850                 855                 860                 


Gly Phe Leu Met Leu Tyr Thr Phe Val Val Leu Val Gln Met Glu Gln 
865                 870                 875                 880 


Leu Pro Ser Val Gln Glu Trp Ile Val Ile Ala Tyr Ile Phe Thr Tyr 
                885                 890                 895     


Ala Ile Glu Lys Val Arg Glu Ile Phe Met Ser Glu Ala Gly Lys Val 
            900                 905                 910         


Asn Gln Lys Ile Lys Val Trp Phe Ser Asp Tyr Phe Asn Ile Ser Asp 
        915                 920                 925             


Thr Ile Ala Ile Ile Ser Phe Phe Ile Gly Phe Gly Leu Arg Phe Gly 
    930                 935                 940                 


Ala Lys Trp Asn Phe Ala Asn Ala Tyr Asp Asn His Val Phe Val Ala 
945                 950                 955                 960 


Gly Arg Leu Ile Tyr Cys Leu Asn Ile Ile Phe Trp Tyr Val Arg Leu 
                965                 970                 975     


Leu Asp Phe Leu Ala Val Asn Gln Gln Ala Gly Pro Tyr Val Met Met 
            980                 985                 990         


Ile Gly Lys Met Val Ala Asn Met  Phe Tyr Ile Val Val  Ile Met Ala 
        995                 1000                 1005             


Leu Val  Leu Leu Ser Phe Gly  Val Pro Arg Lys Ala  Ile Leu Tyr 
    1010                 1015                 1020             


Pro His  Glu Ala Pro Ser Trp  Thr Leu Ala Lys Asp  Ile Val Phe 
    1025                 1030                 1035             


His Pro  Tyr Trp Met Ile Phe  Gly Glu Val Tyr Ala  Tyr Glu Ile 
    1040                 1045                 1050             


Asp Val  Cys Ala Asn Asp Ser  Val Ile Pro Gln Ile  Cys Gly Pro 
    1055                 1060                 1065             


Gly Thr  Trp Leu Thr Pro Phe  Leu Gln Ala Val Tyr  Leu Phe Val 
    1070                 1075                 1080             


Gln Tyr  Ile Ile Met Val Asn  Leu Leu Ile Ala Phe  Phe Asn Asn 
    1085                 1090                 1095             


Val Tyr  Leu Gln Val Lys Ala  Ile Ser Asn Ile Val  Trp Lys Tyr 
    1100                 1105                 1110             


Gln Arg  Tyr His Phe Ile Met  Ala Tyr His Glu Lys  Pro Val Leu 
    1115                 1120                 1125             


Pro Pro  Pro Leu Ile Ile Leu  Ser His Ile Val Ser  Leu Phe Cys 
    1130                 1135                 1140             


Cys Ile  Cys Lys Arg Arg Lys  Lys Asp Lys Thr Ser  Asp Gly Pro 
    1145                 1150                 1155             


Lys Leu  Phe Leu Thr Glu Glu  Asp Gln Lys Lys Leu  His Asp Phe 
    1160                 1165                 1170             


Glu Glu  Gln Cys Val Glu Met  Tyr Phe Asn Glu Lys  Asp Asp Lys 
    1175                 1180                 1185             


Phe His  Ser Gly Ser Glu Glu  Arg Ile Arg Val Thr  Phe Glu Arg 
    1190                 1195                 1200             


Val Glu  Gln Met Cys Ile Gln  Ile Lys Glu Val Gly  Asp Arg Val 
    1205                 1210                 1215             


Asn Tyr  Ile Lys Arg Ser Leu  Gln Ser Leu Asp Ser  Gln Ile Gly 
    1220                 1225                 1230             


His Leu  Gln Asp Leu Ser Ala  Leu Thr Val Asp Thr  Leu Lys Thr 
    1235                 1240                 1245             


Leu Thr  Ala Gln Lys Ala Ser  Glu Ala Ser Lys Val  His Asn Glu 
    1250                 1255                 1260             


Ile Thr  Arg Glu Leu Ser Ile  Ser Lys His Leu Ala  Gln Asn Leu 
    1265                 1270                 1275             


Ile Asp  Asp Gly Pro Val Arg  Pro Ser Val Trp Lys  Lys His Gly 
    1280                 1285                 1290             


Val Val  Asn Thr Leu Ser Ser  Ser Leu Pro Gln Gly  Asp Leu Glu 
    1295                 1300                 1305             


Ser Asn  Asn Pro Phe His Cys  Asn Ile Leu Met Lys  Asp Asp Lys 
    1310                 1315                 1320             


Asp Pro  Gln Cys Asn Ile Phe  Gly Gln Asp Leu Pro  Ala Val Pro 
    1325                 1330                 1335             


Gln Arg  Lys Glu Phe Asn Phe  Pro Glu Ala Gly Ser  Ser Ser Gly 
    1340                 1345                 1350             


Ala Leu  Phe Pro Ser Ala Val  Ser Pro Pro Glu Leu  Arg Gln Arg 
    1355                 1360                 1365             


Leu His  Gly Val Glu Leu Leu  Lys Ile Phe Asn Lys  Asn Gln Lys 
    1370                 1375                 1380             


Leu Gly  Ser Ser Ser Thr Ser  Ile Pro His Leu Ser  Ser Pro Pro 
    1385                 1390                 1395             


Thr Lys  Phe Phe Val Ser Thr  Pro Ser Gln Pro Ser  Cys Lys Ser 
    1400                 1405                 1410             


His Leu  Glu Thr Gly Thr Lys  Asp Gln Glu Thr Val  Cys Ser Lys 
    1415                 1420                 1425             


Ala Thr  Glu Gly Asp Asn Thr  Glu Phe Gly Ala Phe  Val Gly His 
    1430                 1435                 1440             


Arg Asp  Ser Met Asp Leu Gln  Arg Phe Lys Glu Thr  Ser Asn Lys 
    1445                 1450                 1455             


Ile Lys  Ile Leu Ser Asn Asn  Asn Thr Ser Glu Asn  Thr Leu Lys 
    1460                 1465                 1470             


Arg Val  Ser Ser Leu Ala Gly  Phe Thr Asp Cys His  Arg Thr Ser 
    1475                 1480                 1485             


Ile Pro  Val His Ser Lys Gln  Ala Glu Lys Ile Ser  Arg Arg Pro 
    1490                 1495                 1500             


Ser Thr  Glu Asp Thr His Glu  Val Asp Ser Lys Ala  Ala Leu Ile 
    1505                 1510                 1515             


Pro Asp  Trp Leu Gln Asp Arg  Pro Ser Asn Arg Glu  Met Pro Ser 
    1520                 1525                 1530             


Glu Glu  Gly Thr Leu Asn Gly  Leu Thr Ser Pro Phe  Lys Pro Ala 
    1535                 1540                 1545             


Met Asp  Thr Asn Tyr Tyr Tyr  Ser Ala Val Glu Arg  Asn Asn Leu 
    1550                 1555                 1560             


Met Arg  Leu Ser Gln Ser Ile  Pro Phe Thr Pro Val  Pro Pro Arg 
    1565                 1570                 1575             


Gly Glu  Pro Val Thr Val Tyr  Arg Leu Glu Glu Ser  Ser Pro Asn 
    1580                 1585                 1590             


Ile Leu  Asn Asn Ser Met Ser  Ser Trp Ser Gln Leu  Gly Leu Cys 
    1595                 1600                 1605             


Ala Lys  Ile Glu Phe Leu Ser  Lys Glu Glu Met Gly  Gly Gly Leu 
    1610                 1615                 1620             


Arg Arg  Ala Val Lys Val Gln  Cys Thr Trp Ser Glu  His Asp Ile 
    1625                 1630                 1635             


Leu Lys  Ser Gly His Leu Tyr  Ile Ile Lys Ser Phe  Leu Pro Glu 
    1640                 1645                 1650             


Val Val  Asn Thr Trp Ser Ser  Ile Tyr Lys Glu Asp  Thr Val Leu 
    1655                 1660                 1665             


His Leu  Cys Leu Arg Glu Ile  Gln Gln Gln Arg Ala  Ala Gln Lys 
    1670                 1675                 1680             


Leu Thr  Phe Ala Phe Asn Gln  Met Lys Pro Lys Ser  Ile Pro Tyr 
    1685                 1690                 1695             


Ser Pro  Arg Phe Leu Glu Val  Phe Leu Leu Tyr Cys  His Ser Ala 
    1700                 1705                 1710             


Gly Gln  Trp Phe Ala Val Glu  Glu Cys Met Thr Gly  Glu Phe Arg 
    1715                 1720                 1725             


Lys Tyr  Asn Asn Asn Asn Gly  Asp Glu Ile Ile Pro  Thr Asn Thr 
    1730                 1735                 1740             


Leu Glu  Glu Ile Met Leu Ala  Phe Ser His Trp Thr  Tyr Glu Tyr 
    1745                 1750                 1755             


Thr Arg  Gly Glu Leu Leu Val  Leu Asp Leu Gln Gly  Val Gly Glu 
    1760                 1765                 1770             


Asn Leu  Thr Asp Pro Ser Val  Ile Lys Ala Glu Glu  Lys Arg Ser 
    1775                 1780                 1785             


Cys Asp  Met Val Phe Gly Pro  Ala Asn Leu Gly Glu  Asp Ala Ile 
    1790                 1795                 1800             


Lys Asn  Phe Arg Ala Lys His  His Cys Asn Ser Cys  Cys Arg Lys 
    1805                 1810                 1815             


Leu Lys  Leu Pro Asp Leu Lys  Arg Asn Asp Tyr Thr  Pro Asp Lys 
    1820                 1825                 1830             


Ile Ile  Phe Pro Gln Asp Glu  Pro Ser Asp Leu Asn  Leu Gln Pro 
    1835                 1840                 1845             


Gly Asn  Ser Thr Lys Glu Ser  Glu Ser Thr Asn Ser  Val Arg Leu 
    1850                 1855                 1860             


Met Leu  
    1865 


<210>  18
<211>  1124
<212>  PRT
<213>  Drosophila melanogaster

<400>  18

Met Gly Arg Lys Lys Lys Leu Pro Thr Gly Val Ser Ser Gly Val Ser 
1               5                   10                  15      


His Ala Ser Ser Ala Pro Lys Ser Val Gly Gly Cys Cys Val Pro Leu 
            20                  25                  30          


Gly Leu Pro Gln Pro Leu Leu Leu Glu Glu Lys Lys Phe Leu Leu Ala 
        35                  40                  45              


Val Glu Arg Gly Asp Met Pro Asn Val Arg Arg Ile Leu Gln Lys Ala 
    50                  55                  60                  


Leu Arg His Gln His Ile Asn Ile Asn Cys Met Asp Pro Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Leu Thr Leu Ala Ile Asp Asn Glu Asn Leu Glu Met Val Glu 
                85                  90                  95      


Leu Leu Val Val Met Gly Val Glu Thr Lys Asp Ala Leu Leu His Ala 
            100                 105                 110         


Ile Asn Ala Glu Phe Val Glu Ala Val Glu Leu Leu Leu Glu His Glu 
        115                 120                 125             


Glu Leu Ile Tyr Lys Glu Gly Glu Pro Tyr Ser Trp Gln Lys Val Asp 
    130                 135                 140                 


Ile Asn Thr Ala Met Phe Ala Pro Asp Ile Thr Pro Leu Met Leu Ala 
145                 150                 155                 160 


Ala His Lys Asn Asn Phe Glu Ile Leu Arg Ile Leu Leu Asp Arg Gly 
                165                 170                 175     


Ala Ala Val Pro Val Pro His Asp Ile Arg Cys Gly Cys Glu Glu Cys 
            180                 185                 190         


Val Arg Leu Thr Ala Glu Asp Ser Leu Arg His Ser Leu Ser Arg Val 
        195                 200                 205             


Asn Ile Tyr Arg Ala Leu Cys Ser Pro Ser Leu Ile Cys Leu Thr Ser 
    210                 215                 220                 


Asn Asp Pro Ile Ile Thr Ala Phe Gln Leu Ser Trp Glu Leu Arg Asn 
225                 230                 235                 240 


Leu Ala Leu Thr Glu Gln Glu Cys Lys Ser Glu Tyr Met Asp Leu Arg 
                245                 250                 255     


Arg Gln Cys Gln Lys Phe Ala Val Asp Leu Leu Asp Gln Thr Arg Thr 
            260                 265                 270         


Ser Asn Glu Leu Ala Ile Ile Leu Asn Tyr Asp Pro Gln Met Ser Ser 
        275                 280                 285             


Tyr Glu Pro Gly Asp Arg Met Ser Leu Thr Arg Leu Val Gln Ala Ile 
    290                 295                 300                 


Ser Tyr Lys Gln Lys Lys Phe Val Ala His Ser Asn Ile Gln Gln Leu 
305                 310                 315                 320 


Leu Ser Ser Ile Trp Tyr Asp Gly Leu Pro Gly Phe Arg Arg Lys Ser 
                325                 330                 335     


Ile Val Asp Lys Val Ile Cys Ile Ala Gln Val Ala Val Leu Phe Pro 
            340                 345                 350         


Leu Tyr Cys Leu Ile Tyr Met Cys Ala Pro Asn Cys Arg Thr Gly Gln 
        355                 360                 365             


Leu Met Arg Lys Pro Phe Met Lys Phe Leu Ile His Ala Ser Ser Tyr 
    370                 375                 380                 


Leu Phe Phe Leu Phe Ile Leu Ile Leu Val Ser Gln Arg Ala Asp Asp 
385                 390                 395                 400 


Asp Phe Val Arg Ile Phe Gly Thr Thr Arg Met Lys Lys Glu Leu Ala 
                405                 410                 415     


Glu Gln Glu Leu Arg Gln Arg Gly Gln Thr Pro Ser Lys Leu Glu Leu 
            420                 425                 430         


Ile Val Val Met Tyr Val Ile Gly Phe Val Trp Glu Glu Val Gln Glu 
        435                 440                 445             


Ile Phe Ala Val Gly Met Lys Ser Tyr Leu Arg Asn Met Trp Asn Phe 
    450                 455                 460                 


Ile Asp Phe Leu Arg Asn Ser Leu Tyr Val Ser Val Met Cys Leu Arg 
465                 470                 475                 480 


Ala Phe Ala Tyr Ile Gln Gln Ala Thr Glu Ile Ala Arg Asp Pro Gln 
                485                 490                 495     


Met Ala Tyr Ile Pro Arg Glu Lys Trp His Asp Phe Asp Pro Gln Leu 
            500                 505                 510         


Ile Ala Glu Gly Leu Phe Ala Ala Ala Asn Val Phe Ser Ala Leu Lys 
        515                 520                 525             


Leu Val His Leu Phe Ser Ile Asn Pro His Leu Gly Pro Leu Gln Ile 
    530                 535                 540                 


Ser Leu Gly Arg Met Val Ile Asp Ile Val Lys Phe Phe Phe Ile Tyr 
545                 550                 555                 560 


Thr Leu Val Leu Phe Ala Phe Ala Cys Gly Leu Asn Gln Leu Leu Trp 
                565                 570                 575     


Tyr Phe Ala Ala Leu Glu Lys Ser Lys Cys Tyr Val Leu Pro Gly Gly 
            580                 585                 590         


Glu Ala Asp Trp Gly Ser His Gly Asp Ser Cys Met Lys Trp Arg Arg 
        595                 600                 605             


Phe Gly Asn Leu Phe Glu Ser Ser Gln Ser Leu Phe Trp Ala Ser Phe 
    610                 615                 620                 


Gly Met Val Gly Leu Asp Asp Phe Glu Leu Ser Gly Ile Lys Ser Tyr 
625                 630                 635                 640 


Thr Arg Phe Trp Gly Leu Leu Met Phe Gly Ser Tyr Ser Val Ile Asn 
                645                 650                 655     


Val Ile Val Leu Leu Asn Leu Leu Ile Ala Met Met Ser Asn Ser Tyr 
            660                 665                 670         


Ala Met Ile Asp Glu His Ser Asp Thr Glu Trp Lys Phe Ala Arg Thr 
        675                 680                 685             


Lys Leu Trp Met Ser Tyr Phe Glu Asp Ser Ala Thr Leu Pro Pro Pro 
    690                 695                 700                 


Phe Asn Val Leu Pro Ser Val Lys Trp Val Ile Arg Ile Phe Arg Lys 
705                 710                 715                 720 


Ser Ser Lys Thr Ile Asp Arg Gln Arg Ser Lys Lys Arg Lys Glu Gln 
                725                 730                 735     


Glu Gln Phe Ser Glu Tyr Asp Asn Ile Met Arg Ser Leu Val Trp Arg 
            740                 745                 750         


Tyr Val Ala Ala Met His Arg Lys Phe Glu Asn Asn Pro Val Ser Glu 
        755                 760                 765             


Asp Asp Ile Asn Glu Val Lys Ser Glu Ile Asn Thr Met Arg Tyr Glu 
    770                 775                 780                 


Met Leu Glu Ile Phe Glu Asn Ser Gly Met Asp Val Ser Ser Ala Asn 
785                 790                 795                 800 


Lys Lys Glu Arg Gln Pro Arg Pro Arg Arg Ile Lys Val Trp Glu Arg 
                805                 810                 815     


Arg Leu Met Lys Gly Phe Gln Val Ala Pro Val Gln Asn Gly Cys Glu 
            820                 825                 830         


Leu Asp Ala Phe Gly Asn Val Asn Gly Gln Gly Glu Met Gln Glu Ile 
        835                 840                 845             


Lys Val Glu Ser Ile Pro Ser Lys Pro Ala Lys Glu Thr Ala Lys Glu 
    850                 855                 860                 


Arg Phe Gln Arg Val Ala Arg Thr Val Leu Leu Gln Ser Thr Thr His 
865                 870                 875                 880 


Lys Trp Asn Val Val Leu Arg Ala Ala Lys Asp Ser Gln Ile Gly Arg 
                885                 890                 895     


Cys Thr Lys Asn Glu Arg Lys Ser Leu Gln Asn Leu Gly Arg Ala Ile 
            900                 905                 910         


Glu Glu Ala Lys Arg Leu Ile Met Leu Asn Pro Gly Cys Pro Ser Gly 
        915                 920                 925             


Arg Glu Ser Pro Ile Arg Ile Glu Phe Glu Asp Glu Lys Thr Ser Thr 
    930                 935                 940                 


Leu Leu Glu Leu Leu Asn Gln Ile Ser Ala Glu Ile Ser Asp Ser Glu 
945                 950                 955                 960 


Lys Pro Lys Ile Arg Pro Ile Trp Arg Pro Pro Leu Lys Thr Val Pro 
                965                 970                 975     


Ala Arg Ala Met Ala Ala Asn Asn Thr Arg Ser Leu Thr Ala Pro Glu 
            980                 985                 990         


Leu Lys Ile Ser Arg Lys Ser Ser  Pro Ala Pro Thr Pro  Thr Pro Thr 
        995                 1000                 1005             


Pro Gly  Val Ser His Thr Ala  Leu Ser Gln Phe Arg  Asn Arg Glu 
    1010                 1015                 1020             


Leu Pro  Leu Cys Pro Ser Lys  Leu Ile Ala Asn Ser  Ala Pro Ser 
    1025                 1030                 1035             


Ala Pro  Thr Ala Pro Pro Lys  Lys Ser Ala Pro Thr  Ala Pro Thr 
    1040                 1045                 1050             


Pro Thr  Tyr Lys Pro Thr Thr  His Ala Pro Phe Ser  Val Glu Gly 
    1055                 1060                 1065             


Gly Asn  Arg Glu Asn Thr Arg  Ala Ser Asp Gly Val  Arg Ser Asp 
    1070                 1075                 1080             


Asn Ser  Asn Phe Asp Ile His  Val Val Asp Leu Asp  Glu Lys Gly 
    1085                 1090                 1095             


Gly His  Leu Gly Arg Asp Asn  Val Ser Asp Ile Ser  Ser Ile Ala 
    1100                 1105                 1110             


Ser Thr  Ser Pro Gln Arg Pro  Lys His Arg Asn 
    1115                 1120                 


<210>  19
<211>  1863
<212>  PRT
<213>  Mus musculus

<400>  19

Met Ser Gln Lys Ser Trp Ile Glu Ser Thr Leu Thr Lys Arg Glu Cys 
1               5                   10                  15      


Val Tyr Ile Ile Pro Ser Ser Lys Asp Pro His Arg Cys Leu Pro Gly 
            20                  25                  30          


Cys Gln Ile Cys Gln Gln Leu Val Arg Cys Phe Cys Gly Arg Leu Val 
        35                  40                  45              


Lys Gln His Ala Cys Phe Thr Ala Ser Leu Ala Met Lys Tyr Ser Asp 
    50                  55                  60                  


Val Arg Leu Gly Glu His Phe Asn Gln Ala Ile Glu Glu Trp Ser Val 
65                  70                  75                  80  


Glu Lys His Thr Glu Gln Ser Pro Thr Asp Ala Tyr Gly Val Ile Asn 
                85                  90                  95      


Phe Gln Gly Gly Ser His Ser Tyr Arg Ala Lys Tyr Val Arg Leu Ser 
            100                 105                 110         


Tyr Asp Thr Lys Pro Glu Ile Ile Leu Gln Leu Leu Leu Lys Glu Trp 
        115                 120                 125             


Gln Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly Gly Met Gln 
    130                 135                 140                 


Lys Phe Glu Leu His Pro Arg Ile Lys Gln Leu Leu Gly Lys Gly Leu 
145                 150                 155                 160 


Ile Lys Ala Ala Val Thr Thr Gly Ala Trp Ile Leu Thr Gly Gly Val 
                165                 170                 175     


Asn Thr Gly Val Ala Lys His Val Gly Asp Ala Leu Lys Glu His Ala 
            180                 185                 190         


Ser Arg Ser Ser Arg Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly 
        195                 200                 205             


Val Ile Glu Asn Arg Asn Asp Leu Val Gly Arg Asp Val Val Ala Pro 
    210                 215                 220                 


Tyr Gln Thr Leu Leu Asn Pro Leu Ser Lys Leu Asn Val Leu Asn Asn 
225                 230                 235                 240 


Leu His Ser His Phe Ile Leu Val Asp Asp Gly Thr Val Gly Lys Tyr 
                245                 250                 255     


Gly Ala Glu Val Arg Leu Arg Arg Glu Leu Glu Lys Thr Ile Asn Gln 
            260                 265                 270         


Gln Arg Ile His Ala Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu 
        275                 280                 285             


Ile Phe Glu Gly Gly Pro Asn Val Ile Leu Thr Val Leu Glu Tyr Leu 
    290                 295                 300                 


Gln Glu Ser Pro Pro Val Pro Val Val Val Cys Glu Gly Thr Gly Arg 
305                 310                 315                 320 


Ala Ala Asp Leu Leu Ala Tyr Ile His Lys Gln Thr Glu Glu Gly Gly 
                325                 330                 335     


Asn Leu Pro Asp Ala Ala Glu Pro Asp Ile Ile Ser Thr Ile Lys Lys 
            340                 345                 350         


Thr Phe Asn Phe Gly Gln Ser Glu Ala Val His Leu Phe Gln Thr Met 
        355                 360                 365             


Met Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe His Ile Gly 
    370                 375                 380                 


Ser Glu Asp His Gln Asp Ile Asp Val Ala Ile Leu Thr Ala Leu Leu 
385                 390                 395                 400 


Lys Gly Thr Asn Ala Ser Ala Phe Asp Gln Leu Ile Leu Thr Leu Ala 
                405                 410                 415     


Trp Asp Arg Val Asp Ile Ala Lys Asn His Val Phe Val Tyr Gly Gln 
            420                 425                 430         


Gln Trp Leu Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val 
        435                 440                 445             


Met Asp Arg Val Ser Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser 
    450                 455                 460                 


Met His Lys Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr 
465                 470                 475                 480 


Lys Gln Gly Pro Thr Asn Pro Met Leu Phe His Leu Ile Arg Asp Val 
                485                 490                 495     


Lys Gln Gly Asn Leu Pro Pro Gly Tyr Lys Ile Thr Leu Ile Asp Ile 
            500                 505                 510         


Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Thr Tyr Arg Cys Thr Tyr 
        515                 520                 525             


Thr Arg Lys Arg Phe Arg Leu Ile Tyr Asn Ser Leu Gly Gly Asn Asn 
    530                 535                 540                 


Arg Arg Ser Gly Arg Asn Thr Ser Ser Ser Thr Pro Gln Leu Arg Lys 
545                 550                 555                 560 


Ser His Glu Thr Phe Gly Asn Arg Ala Asp Lys Lys Glu Lys Met Arg 
                565                 570                 575     


His Asn His Phe Ile Lys Thr Ala Gln Pro Tyr Arg Pro Lys Met Asp 
            580                 585                 590         


Ala Ser Met Glu Glu Gly Lys Lys Lys Arg Thr Lys Asp Glu Ile Val 
        595                 600                 605             


Asp Ile Asp Asp Pro Glu Thr Lys Arg Phe Pro Tyr Pro Leu Asn Glu 
    610                 615                 620                 


Leu Leu Ile Trp Ala Cys Leu Met Lys Arg Gln Val Met Ala Arg Phe 
625                 630                 635                 640 


Leu Trp Gln His Gly Glu Glu Ser Met Ala Lys Ala Leu Val Ala Cys 
                645                 650                 655     


Lys Ile Tyr Arg Ser Met Ala Tyr Glu Ala Lys Gln Ser Asp Leu Val 
            660                 665                 670         


Asp Asp Thr Ser Glu Glu Leu Lys Gln Tyr Ser Asn Asp Phe Gly Gln 
        675                 680                 685             


Leu Ala Val Glu Leu Leu Glu Gln Ser Phe Arg Gln Asp Glu Thr Met 
    690                 695                 700                 


Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ser Thr 
705                 710                 715                 720 


Cys Leu Lys Leu Ala Val Ser Ser Arg Leu Arg Pro Phe Val Ala His 
                725                 730                 735     


Thr Cys Thr Gln Met Leu Leu Ser Asp Met Trp Met Gly Arg Leu Asn 
            740                 745                 750         


Met Arg Lys Asn Ser Trp Tyr Lys Val Ile Leu Ser Ile Leu Val Pro 
        755                 760                 765             


Pro Ala Ile Leu Met Leu Glu Tyr Lys Thr Lys Ala Glu Met Ser His 
    770                 775                 780                 


Ile Pro Gln Ser Gln Asp Ala His Gln Met Thr Met Glu Asp Ser Glu 
785                 790                 795                 800 


Asn Asn Phe His Asn Ile Thr Glu Glu Ile Pro Met Glu Val Phe Lys 
                805                 810                 815     


Glu Val Lys Ile Leu Asp Ser Ser Asp Gly Lys Asn Glu Met Glu Ile 
            820                 825                 830         


His Ile Lys Ser Lys Lys Leu Pro Ile Thr Arg Lys Phe Tyr Ala Phe 
        835                 840                 845             


Tyr His Ala Pro Ile Val Lys Phe Trp Phe Asn Thr Leu Ala Tyr Leu 
    850                 855                 860                 


Gly Phe Leu Met Leu Tyr Thr Phe Val Val Leu Val Lys Met Glu Gln 
865                 870                 875                 880 


Leu Pro Ser Val Gln Glu Trp Ile Val Ile Ala Tyr Ile Phe Thr Tyr 
                885                 890                 895     


Ala Ile Glu Lys Val Arg Glu Val Phe Met Ser Glu Ala Gly Lys Ile 
            900                 905                 910         


Ser Gln Lys Ile Lys Val Trp Phe Ser Asp Tyr Phe Asn Val Ser Asp 
        915                 920                 925             


Thr Ile Ala Ile Ile Ser Phe Phe Val Gly Phe Gly Leu Arg Phe Gly 
    930                 935                 940                 


Ala Lys Trp Asn Tyr Ile Asn Ala Tyr Asp Asn His Val Phe Val Ala 
945                 950                 955                 960 


Gly Arg Leu Ile Tyr Cys Leu Asn Ile Ile Phe Trp Tyr Val Arg Leu 
                965                 970                 975     


Leu Asp Phe Leu Ala Val Asn Gln Gln Ala Gly Pro Tyr Val Met Met 
            980                 985                 990         


Ile Gly Lys Met Val Ala Asn Met  Phe Tyr Ile Val Val  Ile Met Ala 
        995                 1000                 1005             


Leu Val  Leu Leu Ser Phe Gly  Val Pro Arg Lys Ala  Ile Leu Tyr 
    1010                 1015                 1020             


Pro His  Glu Glu Pro Ser Trp  Ser Leu Ala Lys Asp  Ile Val Phe 
    1025                 1030                 1035             


His Pro  Tyr Trp Met Ile Phe  Gly Glu Val Tyr Ala  Tyr Glu Ile 
    1040                 1045                 1050             


Asp Val  Cys Ala Asn Asp Ser  Thr Leu Pro Thr Ile  Cys Gly Pro 
    1055                 1060                 1065             


Gly Thr  Trp Leu Thr Pro Phe  Leu Gln Ala Val Tyr  Leu Phe Val 
    1070                 1075                 1080             


Gln Tyr  Ile Ile Met Val Asn  Leu Leu Ile Ala Phe  Phe Asn Asn 
    1085                 1090                 1095             


Val Tyr  Leu Gln Val Lys Ala  Ile Ser Asn Ile Val  Trp Lys Tyr 
    1100                 1105                 1110             


Gln Arg  Tyr His Phe Ile Met  Ala Tyr His Glu Lys  Pro Val Leu 
    1115                 1120                 1125             


Pro Pro  Pro Leu Ile Ile Leu  Ser His Ile Val Ser  Leu Phe Cys 
    1130                 1135                 1140             


Cys Val  Cys Lys Arg Arg Lys  Lys Asp Lys Thr Ser  Asp Gly Pro 
    1145                 1150                 1155             


Lys Leu  Phe Leu Thr Glu Glu  Asp Gln Lys Lys Leu  His Asp Phe 
    1160                 1165                 1170             


Glu Glu  Gln Cys Val Glu Met  Tyr Phe Asp Glu Lys  Asp Asp Lys 
    1175                 1180                 1185             


Phe Asn  Ser Gly Ser Glu Glu  Arg Ile Arg Val Thr  Phe Glu Arg 
    1190                 1195                 1200             


Val Glu  Gln Met Ser Ile Gln  Ile Lys Glu Val Gly  Asp Arg Val 
    1205                 1210                 1215             


Asn Tyr  Ile Lys Arg Ser Leu  Gln Ser Leu Asp Ser  Gln Ile Gly 
    1220                 1225                 1230             


His Leu  Gln Asp Leu Ser Ala  Leu Thr Val Asp Thr  Leu Lys Thr 
    1235                 1240                 1245             


Leu Thr  Ala Gln Lys Ala Ser  Glu Ala Ser Lys Val  His Asn Glu 
    1250                 1255                 1260             


Ile Thr  Arg Glu Leu Ser Ile  Ser Lys His Leu Ala  Gln Asn Leu 
    1265                 1270                 1275             


Ile Asp  Asp Val Pro Val Arg  Pro Leu Trp Lys Lys  Pro Ser Ala 
    1280                 1285                 1290             


Val Asn  Thr Leu Ser Ser Ser  Leu Pro Gln Gly Asp  Arg Glu Ser 
    1295                 1300                 1305             


Asn Asn  Pro Phe Leu Cys Asn  Ile Phe Met Lys Asp  Glu Lys Asp 
    1310                 1315                 1320             


Pro Gln  Tyr Asn Leu Phe Gly  Gln Asp Leu Pro Val  Ile Pro Gln 
    1325                 1330                 1335             


Arg Lys  Glu Phe Asn Ile Pro  Glu Ala Gly Ser Ser  Cys Gly Ala 
    1340                 1345                 1350             


Leu Phe  Pro Ser Ala Val Ser  Pro Pro Glu Leu Arg  Gln Arg Arg 
    1355                 1360                 1365             


His Gly  Val Glu Met Leu Lys  Ile Phe Asn Lys Asn  Gln Lys Leu 
    1370                 1375                 1380             


Gly Ser  Ser Pro Asn Ser Ser  Pro His Met Ser Ser  Pro Pro Thr 
    1385                 1390                 1395             


Lys Phe  Ser Val Ser Thr Pro  Ser Gln Pro Ser Cys  Lys Ser His 
    1400                 1405                 1410             


Leu Glu  Ser Thr Thr Lys Asp  Gln Glu Pro Ile Phe  Tyr Lys Ala 
    1415                 1420                 1425             


Ala Glu  Gly Asp Asn Ile Glu  Phe Gly Ala Phe Val  Gly His Arg 
    1430                 1435                 1440             


Asp Ser  Met Asp Leu Gln Arg  Phe Lys Glu Thr Ser  Asn Lys Ile 
    1445                 1450                 1455             


Arg Glu  Leu Leu Ser Asn Asp  Thr Pro Glu Asn Thr  Leu Lys His 
    1460                 1465                 1470             


Val Gly  Ala Ala Gly Tyr Ser  Glu Cys Cys Lys Thr  Ser Thr Ser 
    1475                 1480                 1485             


Leu His  Ser Val Gln Ala Glu  Ser Cys Ser Arg Arg  Ala Ser Thr 
    1490                 1495                 1500             


Glu Asp  Ser Pro Glu Val Asp  Ser Lys Ala Ala Leu  Leu Pro Asp 
    1505                 1510                 1515             


Trp Leu  Arg Asp Arg Pro Ser  Asn Arg Glu Met Pro  Ser Glu Gly 
    1520                 1525                 1530             


Gly Thr  Leu Asn Gly Leu Ala  Ser Pro Phe Lys Pro  Val Leu Asp 
    1535                 1540                 1545             


Thr Asn  Tyr Tyr Tyr Ser Ala  Val Glu Arg Asn Asn  Leu Met Arg 
    1550                 1555                 1560             


Leu Ser  Gln Ser Ile Pro Phe  Val Pro Val Pro Pro  Arg Gly Glu 
    1565                 1570                 1575             


Pro Val  Thr Val Tyr Arg Leu  Glu Glu Ser Ser Pro  Ser Ile Leu 
    1580                 1585                 1590             


Asn Asn  Ser Met Ser Ser Trp  Ser Gln Leu Gly Leu  Cys Ala Lys 
    1595                 1600                 1605             


Ile Glu  Phe Leu Ser Lys Glu  Glu Met Gly Gly Gly  Leu Arg Arg 
    1610                 1615                 1620             


Ala Val  Lys Val Leu Cys Thr  Trp Ser Glu His Asp  Ile Leu Lys 
    1625                 1630                 1635             


Ser Gly  His Leu Tyr Ile Ile  Lys Ser Phe Leu Pro  Glu Val Ile 
    1640                 1645                 1650             


Asn Thr  Trp Ser Ser Ile Tyr  Lys Glu Asp Thr Val  Leu His Leu 
    1655                 1660                 1665             


Cys Leu  Arg Glu Ile Gln Gln  Gln Arg Ala Ala Gln  Lys Leu Thr 
    1670                 1675                 1680             


Phe Ala  Phe Asn Gln Met Lys  Pro Lys Ser Ile Pro  Tyr Ser Pro 
    1685                 1690                 1695             


Arg Phe  Leu Glu Val Phe Leu  Leu Tyr Cys His Ser  Ala Gly Gln 
    1700                 1705                 1710             


Trp Phe  Ala Val Glu Glu Cys  Met Thr Gly Glu Phe  Arg Lys Tyr 
    1715                 1720                 1725             


Asn Asn  Asn Asn Gly Asp Glu  Ile Ile Pro Thr Asn  Thr Leu Glu 
    1730                 1735                 1740             


Glu Ile  Met Leu Ala Phe Ser  His Trp Thr Tyr Glu  Tyr Thr Arg 
    1745                 1750                 1755             


Gly Glu  Leu Leu Val Leu Asp  Leu Gln Gly Val Gly  Glu Asn Leu 
    1760                 1765                 1770             


Thr Asp  Pro Ser Val Ile Lys  Ala Glu Glu Lys Arg  Ser Cys Asp 
    1775                 1780                 1785             


Met Val  Phe Gly Pro Ala Asn  Leu Gly Glu Asp Ala  Ile Lys Asn 
    1790                 1795                 1800             


Phe Arg  Ala Lys His His Cys  Asn Ser Cys Cys Arg  Lys Leu Lys 
    1805                 1810                 1815             


Leu Pro  Asp Leu Lys Arg Asn  Asp Tyr Thr Pro Asp  Lys Ile Ile 
    1820                 1825                 1830             


Phe Pro  Gln Asp Glu Ser Ser  Asp Leu Asn Leu Gln  Ser Gly Asn 
    1835                 1840                 1845             


Ser Thr  Lys Glu Ser Glu Ala  Thr Asn Ser Val Arg  Leu Met Leu 
    1850                 1855                 1860             


