                         SEQUENCE LISTING

<110>  wyeth
       
 
<120>  PYRROLO[4,3,2-DE]QUINOLIN-8-AMINE COMPOUNDS AND METHODS OF THEIR 
       PREPARATION AND USE

<130>  AM103210

<150>  61/088192
<151>  2008-08-12

<150>  61/122449
<151>  2008-12-15

<160>  7     

<170>  PatentIn version 3.4

<210>  1
<211>  1449
<212>  DNA
<213>  Actinomycete DPJ-0019

<400>  1
ctcaggacga acgctggcgg cgtgcttaac acatgcaagt cgagcggaaa ggcccttcgg     60

ggtactcgag cggcgaacgg gtgagtaaca cgtgagtaac ctgccctagg ctttgggata    120

accccgggaa accggggcta ataccgaata tgactggctg ccgcatggtg gttggtggaa    180

agatttttcg gcttgggatg gactcgcggc ctatcagctt gttggtgggg taatggccta    240

ccaaggcggc gacgggtagc cggcctgaga gggcgaccgg ccacactggg actgagacac    300

ggcccagact cctacgggag gcagcagtgg ggaatcttgc acaatgggcg gaagcctgat    360

gcagcgacgc cgcgtgaggg atgacggcct tcgggttgta aacctctttc agcagggacg    420

aagcgtttgt gacggtacct gcagaagaag cgccggccaa ctacgtgcca gcagccgcgg    480

taagacgtag ggcgcaagcg ttgtccggat ttattgggcg taaagagctc gtaggcggct    540

tgtcgcgtcg actgtgaaaa cccgtggctc aactgcgggc ttgcagtcga tacgggcagg    600

ctagagttcg gtaggggaga ctggaattcc tggtgtagcg gtgaaatgcg cagatatcag    660

gaggaacacc ggtggcgaag gcgggtctct gggccgatac tgacgctgag gagcgaaagc    720

gtggggagcg aacaggatta gataccctgg tagtccacgc tgtaaacgtt gggcgctagg    780

tgtggggggc ctctccggtt ctctgtgccg cagctaacgc attaagcgcc ccgcctgggg    840

agtacggccg caaggctaaa actcaaagga attgacgggg gcccgcacaa gcggcggagc    900

atgcggatta attcgatgca acgcgaagaa ccttacctgg gtttgacatc gccggaaatc    960

cttcagagat ggggggtcct tcggggccgg tgacaggtgg tgcatggctg tcgtcagctc   1020

gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccttgttcg atgttgccag   1080

cgcgttatgg cggggactca tcgaagactg ccggggtcaa ctcggaggaa ggtggggatg   1140

acgtcaagtc atcatgcccc ttatgtccag ggcttcacgc atgctacaat ggccggtaca   1200

atgggctgcg ataccgtgag gtggagcgaa tcccaaaaag ccggtctcag ttcggatcgg   1260

ggtctgcaac tcgaccccgt gaagtcggag tcgctagtaa tcgcagatca gcaacgctgc   1320

ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac gtcacgaaag tcggcaacac   1380

ccgaagccgg tggcctaacc cttgtggggg gagccgtcga aggtggggct ggcgattggg   1440

acgaagtcg                                                           1449


<210>  2
<211>  1447
<212>  DNA
<213>  Actinomycete DPJ-0024

<400>  2
gctcaggacg aacgctggcg gcgtgcttaa cacatgcaag tcgagcggaa aggcccttcg     60

gggtactcga gcggcgaacg ggtgagtaac acgtgagtaa cctgccccag gctttgggat    120

aaccccggga aaccggggct aataccgaat attaccggct gccgcatggc ggttggtgga    180

aagtttttcg gcttgggatg gactcgcggc ctatcagctt gttggtgggg taatggccta    240

ccaaggcggc gacgggtagc cggcctgaga gggcgaccgg ccacactggg actgagacac    300

ggcccagact cctacgggag gcagcagtgg ggaatcttgc acaatgggcg gaagcctgat    360

gcagcgacgc cgcgtgaggg atgacggcct tcgggttgta aacctctttc agcagggacg    420

aagcgtttgt gacggtacct gcagaagaag cgccggccaa ctacgtgcca gcagccgcgg    480

taagacgtag ggcgcgagcg ttgtccggat ttattgggcg taaagagctc gtaggcggct    540

tgtcgcgtcg actgtgaaaa cccgtggctc aactgcgggc ttgcagtcga tacgggcagg    600

ctagagttcg gtaggggaga ctggaattcc tggtgtagcg gtgaaatgcg cagatatcag    660

gaggaacacc ggtggcgaag gcgggtctct gggccgatac tgacgctgag gagcgaaagc    720

gtggggagcg aacaggatta gataccctgg tagtccacgc tgtaaacgtt gggcgctagg    780

tgtggggggc ctctccggtt ctctgtgccg cagctaacgc attaagcgcc ccgcctgggg    840

agtacggccg caaggctaaa actcaaagga attgacgggg gcccgcacaa gcggcggagc    900

atgcggatta attcgatgca acgcgaagaa ccttacctgg gtttgacatc gccggaaatc    960

cttcagagat ggggggtcct tcggggccgg tgacaggtgg tgcatggctg tcgtcagctc   1020

gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccttgttcg atgttgccag   1080

cgcgttatgg cggggactca tcgaagactg ccggggtcaa ctcggaggaa ggtggggatg   1140

acgtcaagtc atcatgcccc ttatgtccag ggcttcacgc atgctacaat ggccggtaca   1200

atgggctgcg ataccgtgag gtggagcgaa tcccaaaaag ccggtctcag ttcggatcgg   1260

ggtctgcaac tcgaccccgt gaagtcggag tcgctagtaa tcgcagatca gcaacgctgc   1320

ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac gtcacgaaag tcggcaacac   1380

ccgaagccgg tggcctaacc cttgtggggg gagccgtcga aggtggggct ggcgattggg   1440

acgaagt                                                             1447


<210>  3
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Conserved Domain

<400>  3
cggttggtgg aaagtttttc                                                 20


<210>  4
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer 16S-1525F

<400>  4
ggttggatcc acctcctt                                                   18


<210>  5
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 23S-40R

<400>  5
tcccacgtcc ttcatcgg                                                   18


<210>  6
<211>  1479
<212>  DNA
<213>  Streptomyces sp.

<400>  6
agagtttgat cctggctcag gacgaacgct ggcggcgtgc ttaacacatg caagtcgagc     60

ggaaaggccc ttcggggtac tcgagcggcg aacgggtgag taacacgtga gtaacctgcc    120

ccaggctttg ggataacccc gggaaaccgg ggctaatacc ggatatgacc atctgtcgca    180

tggtgggtgg tggaaagatt ttttggcttg ggatgggctc gcggcctatc agcttgttgg    240

tggggtgatg gcctaccaag gcggcgacgg gtagccggcc tgagagggcg accggccaca    300

ctgggactga gacacggccc agactcctac gggaggcagc agtggggaat cttgcacaat    360

gggcggaagc ctgatgcagc gacgccgcgt gagggatgac ggccttcggg ttgtaaacct    420

ctttcagcag ggacgaagcg tttgtgacgg tacctgcaga agaagcgccg gccaactacg    480

tgccagcagc cgcggtaaga cgtagggcgc aagcgttgtc cggatttatt gggcgtaaag    540

agctcgtagg cggcttgtcg cgtcgactgt gaaaacccgt ggctcaactg cgggcttgca    600

gtcgatacgg gcaggctaga gttcggtagg ggagactgga attcctggtg tagcggtgaa    660

atgcgcagat atcaggagga acaccggtgg cgaaggcggg tctctgggcc gatactgacg    720

ctgaggagcg aaagcgtggg gagcgaacag gattagatac cctggtagtc cacgctgtaa    780

acgttgggcg ctaggtgtgg ggggcctctc cggttctctg tgccgcagct aacgcattaa    840

gcgccccgcc tggggagtac ggccgcaagg ctaaaactca aaggaattga cgggggcccg    900

cacaagcggc ggagcatgcg gattaattcg atgcaacgcg aagaacctta cctgggtttg    960

acatcgccgg aaatccttca gagatggggg gtccttcggg gccggtgaca ggtggtgcat   1020

ggctgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt   1080

gttcgatgtt gccagcgcgt tatggcgggg actcatcgaa gactgccggg gtcaactcgg   1140

aggaaggtgg ggatgacgtc aagtcatcat gccccttatg tccagggctt cacgcatgct   1200

acaatggccg gtacagtggg ctgcgatacc gtgaggtgga gcgaatccca aaaagccggt   1260

ctcagttcgg atcggggtct gcaactcgac cccgtgaagt cggagtcgct agtaatcgca   1320

gatcagcaac gctgcggtga atacgttccc gggccttgta cacaccgccc gtcacgtcac   1380

gaaagtcggc aacacccgaa gccggtggcc taacccttgt ggggggagcc gtcgaaggtg   1440

gggctggcga ttgggacgaa gtcgtaacaa ggtagccgt                          1479


<210>  7
<211>  1479
<212>  DNA
<213>  Streptomyces sp.

<400>  7
agagtttgat cctggctcag gacgaacgct ggcggcgtgc ttaacacatg caagtcgagc     60

ggaaaggccc ttcggggtac tcgagcggcg aacgggtgag taacacgtga gtaacctgcc    120

ccaggctttg ggataacccc gggaaaccgg ggctaatacc ggatatgact ggctgccgca    180

tggtggttgg tggaaagatt ttttggcttg ggatgggctc gcggcctatc agcttgttgg    240

tggggtgatg gcctaccaag gcggcgacgg gtagccggcc tgagagggcg accggccaca    300

ctgggactga gacacggccc agactcctac gggaggcagc agtggggaat cttgcacaat    360

gggcggaagc ctgatgcagc gacgccgcgt gagggatgac ggccttcggg ttgtaaacct    420

ctttcagcag ggacgaagcg tttgtgacgg tacctgcaga agaagcgccg gccaactacg    480

tgccagcagc cgcggtaaga cgtagggcgc aagcgttgtc cggatttatt gggcgtaaag    540

agctcgtagg cggcttgtcg cgtcgactgt gaaaacccgt ggctcaactg cgggcttgca    600

gtcgatacgg gcaggctaga gttcggtagg ggagactgga attcctggtg tagcggtgaa    660

atgcgcagat atcaggagga acaccggtgg cgaaggcggg tctctgggcc gatactgacg    720

ctgaggagcg aaagcgtggg gagcgaacag gattagatac cctggtagtc cacgctgtaa    780

acgttgggcg ctaggtgtgg ggagcctctc cggttctctg tgccgcagct aacgcattaa    840

gcgccccgcc tggggagtac ggccgcaagg ctaaaactca aaggaattga cgggggcccg    900

cacaagcggc ggagcatgcg gattaattcg atgcaacgcg aagaacctta cctgggtttg    960

acatcgccgg aaatccttca gagatggggg gtccttcggg gccggtgaca ggtggtgcat   1020

ggctgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt   1080

gttcgatgtt gccagcgcgt tatggcgggg actcatcgaa gactgccggg gtcaactcgg   1140

aggaaggtgg ggatgacgtc aagtcatcat gccccttatg tccagggctt cacgcatgct   1200

acaatggccg gtacaatggg ctgcgatacc gtgaggtgga gcgaatccca aaaagccggt   1260

ctcagttcgg atcggggtct gcaactcgac cccgtgaagt cggagtcgct agtaatcgca   1320

gatcagcaac gctgcggtga atacgttccc gggccttgta cacaccgccc gtcacgtcac   1380

gaaagtcggc aacacccgaa gccggtggcc taacccttgt ggggggagcc gtcgaaggtg   1440

gggctggcga ttgggacgaa gtcgtaacaa ggtagccgt                          1479


