                         SEQUENCE LISTING

<110>  Brainco Biopharma, S.L.
       Guerrero Martinez, Maria J
       Simon Buela, Laureano
       Ferrer - Alcon, Marcel
       Martinez Martinez, Antonio
       Meana, Jose J
       Callado, Luis F
       Uriguen, Leyre
 
<120>  Psychiatric Marker, Model System and Related Methods

<130>  CSC/FP6644298

<150>  US 61/090,607
<151>  2008-08-20

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  3617
<212>  DNA
<213>  Mus musculus

<400>  1
gcggggcgcg cggcccgggg gaggcgacgg tgtcgcggga ggagcatcgg agcccgaaga     60

ctcgaagaac gccatggccc ccattggcct caaggcggtg gtcggagaga agatcatgca    120

tgatgtgatc aagaaggtga agaagaaggg cgagtggaag gtgctggtgg tggaccagtt    180

aagcatgagg atgctgtcct cctgctgcaa gatgacagac atcatgaccg agggcatcac    240

aattgtggag gatatcaaca agcgccgaga gccactcccc agcctggagg ccgtgtacct    300

catcacccca tctgagaagt ctgtccactc tctgatcagt gattttaagg acccgccgac    360

tgctaaatat cgggctgcgc atgtgttctt cacagactcg tgtccagatg ccctatttaa    420

cgagctggta aaatcccgag cagccaaagt catcaagacg ctgacggaaa tcaacattgc    480

gtttctcccc tatgagtccc aggtgtattc cctggactcc gctgactctt tccaaagctt    540

ctacagccct cacaaggcgc agatgaagaa tccgatactg gaacgcctgg cagagcagat    600

cgcaaccctg tgtgccaccc tgaaggagta tccagctgtg cggtatcggg gggagtacaa    660

ggacaatgcc ttgctggctc agctgatcca ggacaagctg gatgcctata aagccgacga    720

tccaacaatg ggggagggtc ccgacaaggc acggtcccag ctcctgatcc tggatcgtgg    780

ctttgacccc agctcccctg tgctccatga actgacattc caggctatga gttatgacct    840

gctgcctatc gaaaatgatg tttacaagta tgagaccagc ggcattggag aggcgcgggt    900

gaaggaggtg ctactggatg aggacgatga cctgtggatt gcgctgcgac acaagcacat    960

cgcagaggtg tcccaggaag tcacccggtc tctgaaggac ttttcctcta gcaagaggat   1020

gaacactggc gagaagacca ccatgcggga cctgtcccag atgctgaaga aaatgcccca   1080

gtaccagaag gagctcagca agtattcgac tcacctgcac cttgctgaag actgcatgaa   1140

gcattaccaa ggcactgtag acaaactctg ccgcgtggag caggacctgg caatgggcac   1200

agatgctgag ggggaaaaaa tcaaggaccc catgagagcc attgtcccca tcctgctgga   1260

tgcgaacgtc agcacttacg acaaaatccg tatcatcctt ctctacatct tcctgaagaa   1320

cggtatcact gaggagaacc taaacaaact catccagcac gctcagatac ccccagagga   1380

cagcgagatc atcaccaaca tggctcacct cggcgtgccc atcgtcacgg attccacact   1440

acgccgccga agcaaaccgg agcggaagga gcgtatcagt gagcagacct accagctctc   1500

acgatggacc ccgatcatta aagacattat ggaggacact atcgaagaca agctggatac   1560

aaagcactac ccatacatct ctacccgctc gtccgcgtcc ttcagcacca ctgctgtgag   1620

tgcccgctat ggacattggc acaagaataa ggcccccggg gagtaccgca gcggtccccg   1680

cctcattatt ttcatccttg ggggtgtgag cctgaatgag atgcgctgtg cttacgaagt   1740

gacccaggcc aacggcaagt gggaagtgct gataggttct actcacattc tcactcccac   1800

caaattcctc atggacctga gacaccccga cttcagggag tcctctaggg tatcttttga   1860

ggatcaggct ccaacaatgg agtgagagcc aaagagacaa agatccacgc acattctcac   1920

cccacagaaa ctgctggaca cgctgaagaa gctgaataaa acagatgaag aaataagcag   1980

ttaaaaaata agctgccccc caaaaccccg gctcccttcc caaaatgctc tgcagctccc   2040

ccgtgcgcca cctcggttac tctgctgcct ccccagccct gcacgccctg gccaccccgt   2100

tgccgtgctg agttcttctc ctgtgcgatg acaccccatc ttgtcctctg aaaagcaaga   2160

gagtaatgtg ttgtttttta aaaatgagca tcttctgtat gtatcccaca gtaagttcac   2220

atgcaagctc cacactgcag aagcgtcaga actccggacc gagtgaattc tcccttattt   2280

atgaccccgt gacctgtata tagccctgtc ccgcgtgtgc acattgcttg aatatggaaa   2340

ggtagatgtg tgggtgtctc tccaagcttg gttggattca tttctgtcct tgttggtgtt   2400

tgttccccgg ataggacatg ctgagggagt gatgttctcg ctagcccctg ctcgctccct   2460

gttctcagcg atgagcagac acctctggag gctggcgtgg aacgagcctc ctctttgcac   2520

ctatggggga ggcttagggt gtccacagga agccagtctg agtgccggcc agtgtggtct   2580

ccagagcctg gcactgcttt ccctgatctg tgtccatact gttgtaacaa gttaagccct   2640

tcaggctaaa tcagcctgcc tagtgccctc ggagcctcca gagttaggtc tgaccagccc   2700

cctgcttgaa cacagtttgg atagaggcca agggtcaggg gtgggctgga agctgtgagt   2760

ttggcactct ggtcaagggt gctttgctgt aggagctagg cctgaagaat gggggccctg   2820

ctgcttagtc agagtcccct cagtttaaga tacttcatca atcttaagtt tgtgtagtgt   2880

acagtcatgt gtcattgtgg ttgtatgaaa aggatcattt tattctttgt attagtcatc   2940

actgtataaa acatagctag ctataaagca gaaattccag aagccgatgc tggaaggatg   3000

gtctccaccc tcaggacgca gcagccccct gagcatgctg ctcaccctgc tgctgtagtc   3060

gtgaaacaaa gacagtggaa gtcacaaaaa tgtccccagc ccagtccccg cccctccctc   3120

ccgcagattt gtacgtatta ctgtgtctcg tgctgtcttc gcaaacgtgg tgtacgcctg   3180

ccgcaggtgt cctgtgccct tctccctccc tgactctaga gtctctcttc tccttagttc   3240

tcaggcctct cccctgctcc tctccagtga accttttccc ttaggactga accacactag   3300

caccggttga tttcttctgt agcgcttctc ccatcccttc ctccggtcaa gcaatgctca   3360

tgcttcagga tcttgtttgt cgaacatgtg gggtttcctt tatgttattt atataaataa   3420

tttctcaaat ggatatttaa aaaaaagcta gtctgtcttg aaacttgtta acttgaaact   3480

cttgaatctc agtgtttaaa gtatggaagc acaaccgtgt accgctctgt accgtcctgt   3540

actgcagcat ttgagtctaa taaagacgtc agctctcaaa aaaaaaaaaa aaaaaaaaaa   3600

aaaaaaaaaa aaaaaaa                                                  3617


<210>  2
<211>  599
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Pro Ile Gly Leu Lys Ala Val Val Gly Glu Lys Ile Met His 
1               5                   10                  15      


Asp Val Ile Lys Lys Val Lys Lys Lys Gly Glu Trp Lys Val Leu Val 
            20                  25                  30          


Val Asp Gln Leu Ser Met Arg Met Leu Ser Ser Cys Cys Lys Met Thr 
        35                  40                  45              


Asp Ile Met Thr Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Leu Pro Ser Leu Glu Ala Val Tyr Leu Ile Thr Pro Ser 
65                  70                  75                  80  


Glu Lys Ser Val His Ser Leu Ile Ser Asp Phe Lys Asp Pro Pro Thr 
                85                  90                  95      


Ala Lys Tyr Arg Ala Ala His Val Phe Phe Thr Asp Ser Cys Pro Asp 
            100                 105                 110         


Ala Leu Phe Asn Glu Leu Val Lys Ser Arg Ala Ala Lys Val Ile Thr 
        115                 120                 125             


Leu Thr Glu Ile Asn Ile Ala Phe Leu Pro Tyr Glu Ser Gln Val Tyr 
    130                 135                 140                 


Ser Leu Asp Ser Ala Asp Ser Phe Gln Ser Phe Tyr Ser Pro His Lys 
145                 150                 155                 160 


Ala Gln Met Lys Asn Pro Ile Leu Glu Arg Leu Ala Glu Gln Ile Ala 
                165                 170                 175     


Thr Leu Cys Ala Thr Leu Lys Glu Tyr Pro Ala Val Arg Tyr Arg Gly 
            180                 185                 190         


Glu Tyr Lys Asp Asn Ala Leu Leu Ala Gln Leu Ile Gln Asp Lys Leu 
        195                 200                 205             


Asp Ala Tyr Lys Ala Asp Asp Pro Thr Met Gly Glu Gly Pro Asp Lys 
    210                 215                 220                 


Ala Arg Ser Gln Leu Leu Ile Leu Asp Arg Gly Phe Asp Pro Ser Ser 
225                 230                 235                 240 


Pro Val Leu His Glu Leu Thr Phe Gln Ala Met Ser Tyr Asp Leu Pro 
                245                 250                 255     


Ile Glu Asn Asp Val Tyr Lys Tyr Glu Thr Ser Gly Ile Gly Glu Ala 
            260                 265                 270         


Arg Val Lys Glu Val Leu Leu Asp Glu Asp Asp Asp Leu Trp Ile Ala 
        275                 280                 285             


Leu Arg His Lys His Ile Ala Glu Val Ser Gln Glu Val Thr Arg Ser 
    290                 295                 300                 


Leu Lys Asp Phe Ser Ser Ser Lys Arg Met Asn Thr Gly Glu Lys Thr 
305                 310                 315                 320 


Thr Met Arg Asp Leu Ser Gln Met Leu Lys Lys Met Pro Gln Tyr Gln 
                325                 330                 335     


Lys Glu Leu Ser Lys Tyr Ser Thr His Leu His Leu Ala Glu Asp Cys 
            340                 345                 350         


Met Lys His Tyr Gln Gly Thr Val Asp Lys Leu Cys Arg Val Glu Gln 
        355                 360                 365             


Asp Leu Ala Met Gly Thr Asp Ala Glu Gly Glu Lys Ile Asp Pro Met 
    370                 375                 380                 


Arg Ala Ile Val Pro Ile Leu Leu Asp Ala Asn Val Ser Thr Tyr Asp 
385                 390                 395                 400 


Lys Ile Arg Ile Ile Leu Leu Tyr Ile Phe Leu Lys Asn Gly Ile Thr 
                405                 410                 415     


Glu Glu Asn Leu Asn Lys Leu Ile Gln His Ala Gln Ile Pro Pro Glu 
            420                 425                 430         


Asp Ser Glu Ile Ile Thr Asn Met Ala His Leu Gly Val Pro Ile Val 
        435                 440                 445             


Thr Asp Ser Thr Leu Arg Arg Arg Ser Lys Pro Glu Arg Lys Glu Arg 
    450                 455                 460                 


Ile Ser Glu Gln Thr Tyr Gln Leu Ser Arg Trp Thr Pro Ile Ile Lys 
465                 470                 475                 480 


Asp Ile Met Glu Asp Thr Ile Glu Asp Lys Leu Asp Thr Lys His Tyr 
                485                 490                 495     


Pro Tyr Ile Ser Thr Arg Ser Ser Ala Ser Phe Ser Thr Ala Val Ser 
            500                 505                 510         


Ala Arg Tyr Gly His Trp His Lys Asn Lys Ala Pro Gly Glu Tyr Arg 
        515                 520                 525             


Ser Gly Pro Arg Leu Ile Ile Phe Ile Leu Gly Gly Val Ser Leu Asn 
    530                 535                 540                 


Glu Met Arg Cys Ala Tyr Glu Val Thr Gln Ala Asn Gly Lys Trp Glu 
545                 550                 555                 560 


Val Leu Ile Gly Ser Thr His Ile Leu Thr Pro Thr Lys Phe Leu Met 
                565                 570                 575     


Asp Leu Arg His Pro Asp Phe Arg Glu Ser Ser Arg Val Ser Phe Glu 
            580                 585                 590         


Asp Gln Ala Pro Thr Met Glu 
        595                 


<210>  3
<211>  3899
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgacgcgcg gctgcggggc ggagagctgc ggctggccca gcgcgcccac ctgaggaggc     60

ggcggggtcc gcaggcgtcg cgggacgagg agatcggagc cgggagactc gcgcagcgcc    120

atggccccca ttggcctcaa agctgttgtc ggagagaaga ttatgcatga tgtgataaag    180

aaggtcaaga agaaggggga atggaaggtg ctggtggtgg atcagttaag catgaggatg    240

ctgtcctcct gctgcaagat gacagacatc atgaccgagg gcataacgat tgtggaagat    300

atcaataagc gcagagagcc gctccccagc ctggaggctg tgtatctcat cactccatcc    360

gagaagtccg tccactctct catcagtgac tttaaggacc cgccgactgc taaataccgg    420

gctgcacacg tcttcttcac tgactcttgt ccagatgccc tgtttaatga actggtaaaa    480

tcccgagcag ccaaagtcat caaaactctg acggaaatca atattgcatt tctcccgtat    540

gaatcccagg tctattcctt ggactctgct gactctttcc aaagcttcta cagtccccac    600

aaggctcaga tgaagaatcc tatactggag cgcctggcag agcagatcgc gaccctttgt    660

gccaccctga aggagtaccc ggctgtgcgg tatcgggggg aatacaagga caatgccctg    720

ctggctcagc taatccagga caagctcgat gcctataaag ctgatgatcc aacaatgggg    780

gagggcccag acaaggcacg ctcccagctc ctgatcctgg atcgaggctt tgaccccagc    840

tcccctgtgc tccatgaatt gacttttcag gctatgagtt atgatctgct gcctatcgaa    900

aatgatgtat acaagtatga gaccagcggc atcggggagg cacgggtgaa ggaggtgctc    960

ctggacgagg acgacgacct gtggatagca ctgcgccaca agcacatcgc agaggtgtcc   1020

caggaagtca cccggtctct gaaagatttt tcttctagca agagaatgaa tactggagag   1080

aagaccacca tgcgggacct gtcccagatg ctgaagaaga tgcctcagta ccagaaagag   1140

ctcagcaagt actccaccca cctgcacctt gctgaggact gtatgaagca ttaccaaggc   1200

accgtagaca aactctgccg agtggagcag gacctggcca tgggcacaga tgctgaggga   1260

gagaagatca aggaccctat gcgagccatc gtccccattc tgctggatgc caatgtcagc   1320

acttatgaca aaatccgcat catccttctc tacatctttt tgaagaatgg catcacggag   1380

gaaaacctga acaaactgat ccagcacgcc cagatacccc cggaggatag tgagatcatc   1440

accaacatgg ctcacctcgg cgtgcccatc gtcaccgatt ccacgctgcg tcgccggagc   1500

aagccggagc ggaaggaacg catcagcgag cagacctacc agctctcacg gtggactccg   1560

attatcaagg acatcatgga ggacactatt gaggacaaac ttgacaccaa acactaccct   1620

tatatctcta cccgttcctc tgcctccttc agcaccaccg ccgtcagcgc ccgctatggg   1680

cactggcata agaacaaggc cccaggcgag taccgcagtg gcccccgcct catcattttc   1740

atccttgggg gtgtgagcct gaatgagatg cgctgcgcct acgaggtgac ccaggccaac   1800

ggaaagtggg aggtgctgat aggttctact cacattctta ctcccaccaa atttctcatg   1860

gacctgagac accccgactt cagggagtcc tctagggtat cttttgagga tcaggctcca   1920

acaatggagt gagagccaaa gaaacaaaga tccacacaca tcctcacccc acagaaactg   1980

ctggacacac tgaagaaact gaataaaaca gatgaagaaa taagcagtta aaaaaataag   2040

tcgcccctcc aaaacacgcc cccatcccac agcgctccgc agcttcccac caccgcccgc   2100

ctcagttcct ttgcgtctgt tgcctcccca gccctgcacg ccctggctgg cactgttgcc   2160

gctgcattct cgtgttcagt gatgccctct tcttgtttga aacaaaagaa aataatgcat   2220

tgtgtttttt aaaaagagta tcttatacat gtatcctaaa aagagaagct catgtgcaat   2280

tggtgcacag caggagaaat ttctggactg ttaggatgaa tggacgcctt ctccccgtta   2340

tttaagattt gtgaccttgt acataaccct gggtgacgtg cacattgctt gggtatggaa   2400

cggtagaaat ttgggtgttt ttaaaacctt gtttggggtt gttcctgtcc ttgttgagaa   2460

tcatagagat gtctgtgttc ttggagtatt tcacactgag gactaatctg ctatcttcat   2520

tccagtccct acccctcagt gcctgctctc atccaaataa cctgggaggt gacaatcagg   2580

atatctcagg aggtccaagg tggaacagac ctctttgcct ttcccagcgt ctcatacccc   2640

cggtagtgca gctgtgggtg gaggctgggg tgtctgcacg aagtcaggcc agcgtcctcc   2700

tccacagcct gtcactgccc cctccccagc ctgtgtccac agtgctgtga tcccgaggga   2760

agtcctccag tctaagtcac agtgccctga caggtgagaa gcaaactccc gctggaagcc   2820

tccatctctt tggaaaaaca gttagtctgg agcctgtggc ccaggccctt ctgtccccag   2880

gcatcatccc aacagctcat tttccctagt ccgccttcgt tcaagggtca ggaatggacc   2940

agaacagatg ggttctggag gcccctgaac agagggctat ggctgtggag aaggttcttg   3000

gcccgttgga ctcacacaga ccctgtaccc tctcggcaag catcttcagt cagattatcc   3060

tcagtttcag atacttcata ataccttgtg ttgtgtgggg tcatacatca tcgtgtttgt   3120

aagagaagat ggtcatttta ttctctgtat aaaacttagc tctaaagcag aaactaaagc   3180

agcaaatgca ggaaggctgt ctcgccatcc tcaagactca gcagctctca ttctccagtg   3240

gtgagcacac catttgtgct gctgctgttg tcgtgaaata taataacagt ggaagtcaca   3300

aaaatgtccc ctgcccagcc ccctcgccgc ccttgacctc ctgcaggcca tgtgtgtatt   3360

acttgtctag tgatgtcctc tcaaagtgct gtacgcgagc tcggcgccac ctccgcctcc   3420

ctttcagagc ctgctccccg ccctctctgc tcgctgcatt gtggtgttct cttctcaagg   3480

ctttgaaatc tccccttgca ctgagattag tcgtcagatc tctccccgtc tccctcccaa   3540

cttatacgac ctgatttcct taggacggaa ccgcaggcac ctgcgccggg cgtcttactc   3600

ccgctgcttg ttctgtcccc tccctcggac caaacagtgc tcatgcttca ggaccttgtt   3660

tgtcgaagat gttggtttcc ctttctctgt tatttatata aaaataattt atcaaaagga   3720

tattttaaaa aagctagtct gtcttgaaac ttgtttacct taaaattatc agaatctcag   3780

tgtttgaaag tactgaagca caaacatata tcatctctgt accattctgt actaaagcac   3840

ttgagtctaa taaataaaga aatcagcacc ccttcccggt gtccaggggg aaaaaaaaa    3899


<210>  4
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Ile Gly Leu Lys Ala Val Val Gly Glu Lys Ile Met His 
1               5                   10                  15      


Asp Val Ile Lys Lys Val Lys Lys Lys Gly Glu Trp Lys Val Leu Val 
            20                  25                  30          


Val Asp Gln Leu Ser Met Arg Met Leu Ser Ser Cys Cys Lys Met Thr 
        35                  40                  45              


Asp Ile Met Thr Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Leu Pro Ser Leu Glu Ala Val Tyr Leu Ile Thr Pro Ser 
65                  70                  75                  80  


Glu Lys Ser Val His Ser Leu Ile Ser Asp Phe Lys Asp Pro Pro Thr 
                85                  90                  95      


Ala Lys Tyr Arg Ala Ala His Val Phe Phe Thr Asp Ser Cys Pro Asp 
            100                 105                 110         


Ala Leu Phe Asn Glu Leu Val Lys Ser Arg Ala Ala Lys Val Ile Lys 
        115                 120                 125             


Thr Leu Thr Glu Ile Asn Ile Ala Phe Leu Pro Tyr Glu Ser Gln Val 
    130                 135                 140                 


Tyr Ser Leu Asp Ser Ala Asp Ser Phe Gln Ser Phe Tyr Ser Pro His 
145                 150                 155                 160 


Lys Ala Gln Met Lys Asn Pro Ile Leu Glu Arg Leu Ala Glu Gln Ile 
                165                 170                 175     


Ala Thr Leu Cys Ala Thr Leu Lys Glu Tyr Pro Ala Val Arg Tyr Arg 
            180                 185                 190         


Gly Glu Tyr Lys Asp Asn Ala Leu Leu Ala Gln Leu Ile Gln Asp Lys 
        195                 200                 205             


Leu Asp Ala Tyr Lys Ala Asp Asp Pro Thr Met Gly Glu Gly Pro Asp 
    210                 215                 220                 


Lys Ala Arg Ser Gln Leu Leu Ile Leu Asp Arg Gly Phe Asp Pro Ser 
225                 230                 235                 240 


Ser Pro Val Leu His Glu Leu Thr Phe Gln Ala Met Ser Tyr Asp Leu 
                245                 250                 255     


Leu Pro Ile Glu Asn Asp Val Tyr Lys Tyr Glu Thr Ser Gly Ile Gly 
            260                 265                 270         


Glu Ala Arg Val Lys Glu Val Leu Leu Asp Glu Asp Asp Asp Leu Trp 
        275                 280                 285             


Ile Ala Leu Arg His Lys His Ile Ala Glu Val Ser Gln Glu Val Thr 
    290                 295                 300                 


Arg Ser Leu Lys Asp Phe Ser Ser Ser Lys Arg Met Asn Thr Gly Glu 
305                 310                 315                 320 


Lys Thr Thr Met Arg Asp Leu Ser Gln Met Leu Lys Lys Met Pro Gln 
                325                 330                 335     


Tyr Gln Lys Glu Leu Ser Lys Tyr Ser Thr His Leu His Leu Ala Glu 
            340                 345                 350         


Asp Cys Met Lys His Tyr Gln Gly Thr Val Asp Lys Leu Cys Arg Val 
        355                 360                 365             


Glu Gln Asp Leu Ala Met Gly Thr Asp Ala Glu Gly Glu Lys Ile Lys 
    370                 375                 380                 


Asp Pro Met Arg Ala Ile Val Pro Ile Leu Leu Asp Ala Asn Val Ser 
385                 390                 395                 400 


Thr Tyr Asp Lys Ile Arg Ile Ile Leu Leu Tyr Ile Phe Leu Lys Asn 
                405                 410                 415     


Gly Ile Thr Glu Glu Asn Leu Asn Lys Leu Ile Gln His Ala Gln Ile 
            420                 425                 430         


Pro Pro Glu Asp Ser Glu Ile Ile Thr Asn Met Ala His Leu Gly Val 
        435                 440                 445             


Pro Ile Val Thr Asp Ser Thr Leu Arg Arg Arg Ser Lys Pro Glu Arg 
    450                 455                 460                 


Lys Glu Arg Ile Ser Glu Gln Thr Tyr Gln Leu Ser Arg Trp Thr Pro 
465                 470                 475                 480 


Ile Ile Lys Asp Ile Met Glu Asp Thr Ile Glu Asp Lys Leu Asp Thr 
                485                 490                 495     


Lys His Tyr Pro Tyr Ile Ser Thr Arg Ser Ser Ala Ser Phe Ser Thr 
            500                 505                 510         


Thr Ala Val Ser Ala Arg Tyr Gly His Trp His Lys Asn Lys Ala Pro 
        515                 520                 525             


Gly Glu Tyr Arg Ser Gly Pro Arg Leu Ile Ile Phe Ile Leu Gly Gly 
    530                 535                 540                 


Val Ser Leu Asn Glu Met Arg Cys Ala Tyr Glu Val Thr Gln Ala Asn 
545                 550                 555                 560 


Gly Lys Trp Glu Val Leu Ile Gly Ser Thr His Ile Leu Thr Pro Gln 
                565                 570                 575     


Lys Leu Leu Asp Thr Leu Lys Lys Leu Asn Lys Thr Asp Glu Glu Ile 
            580                 585                 590         


Ser Ser 
        


<210>  5
<211>  3754
<212>  DNA
<213>  Mus musculus

<400>  5
gcgctgacag cggccggtgc gcgttgtctc cactgtgccc tgcatcccgc atctcgcatc     60

ggccaggcta cccgactcat cgcaaacgtc agtgctcacc atggggaagc ccacgagctc    120

gggatgtgac tggcgccgct tcctacggaa tcactggctg ctgctctcca ccgtggccgc    180

cgtggtacta ggaattgtct taggagtcgt ggttcgagga cacagtgagc tctcaaatct    240

ggataaattc tactttgctt ttcctgggga aattctgatg aggatgctga agctggtcat    300

tttgccgctg atcgtatcca gcatgatcac aggtgtcgct gcactggatt ccaatgtgtc    360

tgggaagatt ggtctgcgcg ctgtagtata ttatttctcc accaccgtca ttgctgtaat    420

cctaggtatt gtgttagttg tgagtatcaa gcctggtgtc actcagaaag tgaatgacat    480

caacaggacg ggtaaaaccc ctgaagtcag caccatggat gccatgttgg acctgatcag    540

gaacatgttc cctgagaatc tggtccaagc ctgttttcag cagtacaaaa ccaagcggga    600

agaggtgaag cctgtgggcg atcctggggg gaacgcaacg gaggtgtctg tcaccacagc    660

catgacaaca atgtctgaga acaagacaaa ggaatacaag atcgtgggcc tgtactcaga    720

cggcatcaat gtcctgggct tgattatctt ctgcctcgtc tttggccttg tcattgggaa    780

aatgggagaa aaggggcaga ttctggtgga cttcttcaat gccttgagtg acgccaccat    840

gaaaatcgtc cagatcatca tgtgctacat gccgattggc attttgttcc taattgctgg    900

gaagatcata gaagttgaag actgggaaat attccgcaag ctgggccttt acatggccac    960

tgtcctgagc gggcttgcaa tccactccct catagttctg cccctgctct atttcatagt   1020

tgtgcggaag aaccctttcc gctttgcctt gggtatggcg caggctctcc tgacagctct   1080

catgatctcg tccagttcgg caaccctgcc agttacattc cgctgtgcgg aagaaaagaa   1140

ccaggtagac aagaggatca cgagatttgt gctgcctgtt ggtgccacca tcaacatgga   1200

cggcactgcg ctctacgaag ctgtggcagc cgtgtttatt gcgcaactga atggcttgga   1260

cctaagcatt gggcagatcg tcaccatcag cattacagcc accgctgcca gcattggagc   1320

tgctggggtg ccccaggctg gcctggtgac catggtgatc gtgctgagtg ctgtggggct   1380

gcctgccgag gacgtcaccc tgatcattgc tgttgactgg ctcctggacc ggttcaggac   1440

catggtgaac gtcctgggtg atgcgtttgg gacgggcatc gtagagaagc tctcgaagaa   1500

ggagctggag cagatggatg tttcgtctga agtcaacatc gtgaacccct ttgccctgga   1560

acccacaacc ctcgataacg aagactcaga taccaagaag tcttatgtca atgggggctt   1620

cgcggtagac aaatctgaca ccatctcgtt cactcagacc tcacagttct agatgcctga   1680

cctcagattg aggcctggga ttgtgaaggg cgtctccaca ggagccatct cctagcaaac   1740

tccgacatta aggaacgaga aggacactaa gagtcaactg tacatttagt ttgataaaca   1800

gacctccaga ttattttcta tatttgactt tatagccttg gttctctggg tttagggatt   1860

tggggtgaga tgaactgaaa ggaaattaag aaagttgtgt tatctggatt ttctaattct   1920

atacaacaga gtttggaagt atatgaagta gtaactgtta ggattaggtc atagatatgg   1980

aagagaaatt ggtttctcat gcatagacca gtgtttgggg tttttaaaca atattattgg   2040

ctacaaattt ttactcaggc tttctattgg caggacttcc tttgcctttt tacttttata   2100

gattataatg catctcaaaa gccctaccca gttaatgtgc caaattttcc attttgacct   2160

catctccagc cactctcaaa ctaccctggg gcggggggag caaaaaagat cagcatagtt   2220

ctgcaataac agtttaaaga tagttgtggg gtttagggga agggaaaggg tttttttatt   2280

caatgtactg tattgagaca ctggtagctg acagccagtg ttcggtatag aactatatgt   2340

atatgtgtgt atatttatta ttttcatgta atttgcaaga cagagatcag taatgaacta   2400

tcaatgtgaa atacgcagct tcccttgtac ttgaatcaaa acgatagctc cagcctaggt   2460

gtgagctcac cagaacactg tcaggcactc tgggatgaga aatcaagttg ctggcttact   2520

gtgattcaag ccctaaagca gaaacatatt atggtgaaac tctaagatga cacagccatt   2580

cacgtacaac atctagggtc aggctcccgg gagggggagg ctccctgcga gcatggaata   2640

agtacattta caaaggcact gtagaggcag gaagtgctcc catagcaaca aaaggcttcg   2700

atcttcaagt agacttcaag acccacttca caaggctgtc acttttctgt tcttggtttt   2760

ctctgcctgc gccccccacc cccagggcca aaccagcagt gacaagccac tgctgtttca   2820

aaacggggtg gcctaaattg aataagcctc attgcaaggt gaccaagcta tccttatact   2880

gtcgtctttt tattttatct tctggttttt ttatttttta gtttttgaga cagcgcctct   2940

ctacatagcc ctggatatcc tggaactcac tatgtagact agactggcct caaactcaca   3000

gagatcctcc tgcctctgcc tctttagtgc tggcctgaaa ggtaggtacc accatgccca   3060

gctctacact gtatttttac agaagaaaag ccaggccata agcgactggt accagcggtt   3120

cagggacaat acttcagtcc ttccctggag aggattgttc tgggaatctc agccttgtgg   3180

cttagaatcc tctgcctgtc tttctcctgc taattcccga agatggctta taaaagtcta   3240

cacttctgtc ctcatcctgt aaataaaact caacaaaaac ttgttcttaa cttggagaca   3300

ggttcataac agccgtgttt ctgtagtgcc cttaagtcat cttaaacccg tgcttttata   3360

tttaagaagc cagaaatcgt gccaaagata gcaggaaggt aaccgaatgc tcagagttgg   3420

ccacgcccac ctgaaagcta ccgactgacc gtcacggtga cccttgactc cgaactttga   3480

agtacaaata tctgtattct ttataggaag taaatctaaa tctaaatgag gttgaatgga   3540

tattttattt aggagtggat ggttctgtcc ccttatcagg tggttctcct tagtggcagt   3600

gaattggcag agccgttcac aagatcattg gggtcatctt gtaaccagcc acttcacaca   3660

ctgtgctgtt aactcaagat gatatgttcc acttccttct caataaacat ctcccccact   3720

ctttctcccc ttaaaaaaaa aaaaaaaaaa aaaa                               3754


<210>  6
<211>  2849
<212>  DNA
<213>  Mus musculus

<400>  6
tagtccaacc agagacagag cacactcacc attttcagag agagggaagg ggctcaacct     60

atgaagagaa aacaaaacaa aacaatgaca aacacagtcc tctttggatt cttctccctt    120

tttatttgta gtaatgaggg atgaacctac agctcggtgc atactagaaa aaaacctacc    180

ctggagctat atccataccc attttctttt tgttttgaaa cagagtctca ctaagttatc    240

caaacagttc tgaatttgca atcctcctgc ctctatctgc caaggagctg ggggatagaa    300

acttgcttgc accgctgtgt tgcgctgtct ttggaggttt aatcaaataa ataaaaatat    360

atagccagct aatgtgtgtt gagtatggat tgcctgtgat ggaggaataa gcacgctact    420

atttcattct gacagccttt attcctgcag ttctgagaag ttggaaggag aaagttcact    480

gaagttgtca atgctcacag atttctctaa caggcgctgg gctctgtgtt ctctccccac    540

caaggcttat ttacccacac tgatgcctta agcttcggga attcctccac gccctctgat    600

ttcctgtaac tgaatagagg cctggcaagg ctctatttag cactcacctc aaggtctcag    660

agttgagtat ttcctgcact gtaggccctt agaagacaga gcaaggcaag catttcccct    720

ttgtgactcc ccactgtgcc ttaccagcat taggaaggcc ttagaatacc tgctagcagg    780

gtactaagca gtctcaacat ttttctccca ttttatctat tcagaggcaa ccacaatgat    840

caatgacaac aggacctgag atcaacagca gcaggtgttt attttaaaag tatagaaaac    900

aggttaaaac actgtaaaca tcaaccagaa aaattaagga ctctgctagc tatttggttt    960

gtttgtttgt ttgtttgttt gtttgttttt gtaataatgg ggtctgcaca caggaccaat   1020

gctgctccat gctaggcaag tttgatcact gaactctatt tctagcactc ttctcgcttt   1080

ttatgttgag ccacaatctt accaacttgc tccggctggc cttgaactca ctttgtaatc   1140

cctacaagcc ctgaacttaa aattctcctg tcttggtctc cggaataggt ctgcctcacc   1200

atgccagttt gtattattac tgataacagt aaaatctgta aatgctgcat atactaaaca   1260

cttcccaaac atccctcatt tagcctctgt ggcagatttt ctactaaccc cggtttacct   1320

aagaatcaag gaaggctggg ggaagttaag acattcctcc actggcctgg agagatgact   1380

cagaggttaa gagcatttgc tgtcctttca gaggacccag attcaagtcc cagttcccac   1440

gtggcagctt agaatcatct gtaactccag ttccaagagc tctggcaccc tcttctgacc   1500

tcagcaggca caaagcatgc gggtacagca catacacaat gcaggcaaga cattcattca   1560

caataaatta gttttgtttt gattttttag gaactacttt tctccaaagt aaattgctgg   1620

agtccattgc caggctatcc taaacaccag tggcagaaga cattttcata aagcccccaa   1680

tgatttcctc aactgccttt ctaatcagct aaacaactaa gtctgacttc gcctcaagta   1740

tattttacta ctctttgttt tagggtaagt tggtggtctt agtagagcac tttgagtttg   1800

gttaaaaatt aacagttgca aatttagaaa cactgttacc ttaggcactg ccatcttaga   1860

agcctaggag tcagggggat cctggacacc acaagaaaac aacccacagc atcaactaag   1920

cagggctcat aggcgctcac agaaactgaa gcggctagca cagggcctac gtgtgtctgt   1980

gctaggttct ctgtgtatgt gttatggttg tgtagcttgg tggtcttgta gaagttgttt   2040

tcttaggtaa atgttatttg tttaatattg gaataaaact aagaaacctt tctggcctgg   2100

gaagccatgt ttctgcccag gaacacagag cacctccagc agctgtctgc tttgaagctg   2160

ctaagagctc gctcaggaag aagtgaagtc atccgcttct atctatcttc tatctataac   2220

gatggcacaa cggttcagta attttgccac aggacagcag aaatgaaggg cgaagaaaaa   2280

ggcgagctgg caatcacttt atttcagttc acttcagtca aacccttgct cccatttttt   2340

ttttttctag tgtgatttca cacaaagtga ctcatgaaaa ttgcacgcat atgtggggag   2400

attagcaata ccggacttca gtgacactga ggccggcttc cattccattc cacttatatt   2460

gacagctgaa cagctgcttt tttttttttt tttttttttt tttttttttt ttttttctcc   2520

cttcagggca aagaacacac acaagcgatg tgtttaaaaa gagatggttt gtatttaaac   2580

tgccagagag aactgacacc acctttagtt taggtagggg atttccgcta gttacttttt   2640

gtcctaacat tggataaagc ccactgctct gagtcactaa ccacttccag ccaatcacag   2700

acagaccaac acacccgccc gcagccaatt ttctgagccc tgccgtgctt taaccgcaga   2760

accaatccga aggacccgct gtcatctttc atccagctgg ttgtcgctgc cgccgcctcc   2820

agattccgaa ggcgaagctc gcgaagcag                                     2849


<210>  7
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Primer

<400>  7
ttgtcgactt cgcgagcttc gccttcggaa tctggag                              37


<210>  8
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Primer

<400>  8
ttggtaccat agtccaacca gagacagagc acactc                               36


