                         SEQUENCE LISTING

<110>  Schering Corp.
 
<120>  IL-8 Biomarker

<130>  JB06829

<150>  61/090,073
<151>  2008-08-19

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  300
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(300)

<400>  1
atg act tcc aag ctg gcc gtg gct ctc ttg gca gcc ttc ctg att tct         48
Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser           
1               5                   10                  15                

gca gct ctg tgt gaa ggt gca gtt ttg cca agg agt gct aaa gaa ctt         96
Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu           
            20                  25                  30                    

aga tgt cag tgc ata aag aca tac tcc aaa cct ttc cac ccc aaa ttt        144
Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe           
        35                  40                  45                        

atc aaa gaa ctg aga gtg att gag agt gga cca cac tgc gcc aac aca        192
Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr           
    50                  55                  60                            

gaa att att gta aag ctt tct gat gga aga gag ctc tgt ctg gac ccc        240
Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro           
65                  70                  75                  80            

aag gaa aac tgg gtg cag agg gtt gtg gag aag ttt ttg aag agg gct        288
Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala           
                85                  90                  95                

gag aat tca taa                                                        300
Glu Asn Ser                                                               
                                                                          


<210>  2
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  3
<211>  1140
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1140)

<400>  3
atg gcg gcg gcg gcg gct cag ggg ggc ggg ggc ggg gag ccc cgt aga         48
Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg           
1               5                   10                  15                

acc gag ggg gtc ggc ccg ggg gtc ccg ggg gag gtg gag atg gtg aag         96
Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys           
            20                  25                  30                    

ggg cag ccg ttc gac gtg ggc ccg cgc tac acg cag ttg cag tac atc        144
Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile           
        35                  40                  45                        

ggc gag ggc gcg tac ggc atg gtc agc tcg gcc tat gac cac gtg cgc        192
Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg           
    50                  55                  60                            

aag act cgc gtg gcc atc aag aag atc agc ccc ttc gaa cat cag acc        240
Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr           
65                  70                  75                  80            

tac tgc cag cgc acg ctc cgg gag atc cag atc ctg ctg cgc ttc cgc        288
Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg           
                85                  90                  95                

cat gag aat gtc atc ggc atc cga gac att ctg cgg gcg tcc acc ctg        336
His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu           
            100                 105                 110                   

gaa gcc atg aga gat gtc tac att gtg cag gac ctg atg gag act gac        384
Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp           
        115                 120                 125                       

ctg tac aag ttg ctg aaa agc cag cag ctg agc aat gac cat atc tgc        432
Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys           
    130                 135                 140                           

tac ttc ctc tac cag atc ctg cgg ggc ctc aag tac atc cac tcc gcc        480
Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala           
145                 150                 155                 160           

aac gtg ctc cac cga gat cta aag ccc tcc aac ctg ctc atc aac acc        528
Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr           
                165                 170                 175               

acc tgc gac ctt aag att tgt gat ttc ggc ctg gcc cgg att gcc gat        576
Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp           
            180                 185                 190                   

cct gag cat gac cac acc ggc ttc ctg acg gag tat gtg gct acg cgc        624
Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg           
        195                 200                 205                       

tgg tac cgg gcc cca gag atc atg ctg aac tcc aag ggc tat acc aag        672
Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys           
    210                 215                 220                           

tcc atc gac atc tgg tct gtg ggc tgc att ctg gct gag atg ctc tct        720
Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser           
225                 230                 235                 240           

aac cgg ccc atc ttc cct ggc aag cac tac ctg gat cag ctc aac cac        768
Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His           
                245                 250                 255               

att ctg ggc atc ctg ggc tcc cca tcc cag gag gac ctg aat tgt atc        816
Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile           
            260                 265                 270                   

atc aac atg aag gcc cga aac tac cta cag tct ctg ccc tcc aag acc        864
Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr           
        275                 280                 285                       

aag gtg gct tgg gcc aag ctt ttc ccc aag tca gac tcc aaa gcc ctt        912
Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu           
    290                 295                 300                           

gac ctg ctg gac cgg atg tta acc ttt aac ccc aat aaa cgg atc aca        960
Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr           
305                 310                 315                 320           

gtg gag gaa gcg ctg gct cac ccc tac ctg gag cag tac tat gac ccg       1008
Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro           
                325                 330                 335               

acg gat gag cca gtg gcc gag gag ccc ttc acc ttc gcc atg gag ctg       1056
Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu           
            340                 345                 350                   

gat gac cta cct aag gag cgg ctg aag gag ctc atc ttc cag gag aca       1104
Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr           
        355                 360                 365                       

gca cgc ttc cag ccc gga gtg ctg gag gcc ccc tag                       1140
Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro                               
    370                 375                                               


<210>  4
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  5
<211>  1083
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1083)

<400>  5
atg gcg gcg gcg gcg gcg gcg ggc gcg ggc ccg gag atg gtc cgc ggg         48
Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly           
1               5                   10                  15                

cag gtg ttc gac gtg ggg ccg cgc tac acc aac ctc tcg tac atc ggc         96
Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly           
            20                  25                  30                    

gag ggc gcc tac ggc atg gtg tgc tct gct tat gat aat gtc aac aaa        144
Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys           
        35                  40                  45                        

gtt cga gta gct atc aag aaa atc agc ccc ttt gag cac cag acc tac        192
Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr           
    50                  55                  60                            

tgc cag aga acc ctg agg gag ata aaa atc tta ctg cgc ttc aga cat        240
Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His           
65                  70                  75                  80            

gag aac atc att gga atc aat gac att att cga gca cca acc atc gag        288
Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu           
                85                  90                  95                

caa atg aaa gat gta tat ata gta cag gac ctc atg gaa aca gat ctt        336
Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu           
            100                 105                 110                   

tac aag ctc ttg aag aca caa cac ctc agc aat gac cat atc tgc tat        384
Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr           
        115                 120                 125                       

ttt ctc tac cag atc ctc aga ggg tta aaa tat atc cat tca gct aac        432
Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn           
    130                 135                 140                           

gtt ctg cac cgt gac ctc aag cct tcc aac ctg ctg ctc aac acc acc        480
Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr           
145                 150                 155                 160           

tgt gat ctc aag atc tgt gac ttt ggc ctg gcc cgt gtt gca gat cca        528
Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro           
                165                 170                 175               

gac cat gat cac aca ggg ttc ctg aca gaa tat gtg gcc aca cgt tgg        576
Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp           
            180                 185                 190                   

tac agg gct cca gaa att atg ttg aat tcc aag ggc tac acc aag tcc        624
Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser           
        195                 200                 205                       

att gat att tgg tct gta ggc tgc att ctg gca gaa atg ctt tct aac        672
Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn           
    210                 215                 220                           

agg ccc atc ttt cca ggg aag cat tat ctt gac cag ctg aac cac att        720
Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile           
225                 230                 235                 240           

ttg ggt att ctt gga tcc cca tca caa gaa gac ctg aat tgt ata ata        768
Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile           
                245                 250                 255               

aat tta aaa gct agg aac tat ttg ctt tct ctt cca cac aaa aat aag        816
Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys           
            260                 265                 270                   

gtg cca tgg aac agg ctg ttc cca aat gct gac tcc aaa gct ctg gac        864
Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp           
        275                 280                 285                       

tta ttg gac aaa atg ttg aca ttc aac cca cac aag agg att gaa gta        912
Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val           
    290                 295                 300                           

gaa cag gct ctg gcc cac cca tat ctg gag cag tat tac gac ccg agt        960
Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser           
305                 310                 315                 320           

gac gag ccc atc gcc gaa gca cca ttc aag ttc gac atg gaa ttg gat       1008
Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp           
                325                 330                 335               

gac ttg cct aag gaa aag ctc aaa gaa cta att ttt gaa gag act gct       1056
Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala           
            340                 345                 350                   

aga ttc cag cca gga tac aga tct taa                                   1083
Arg Phe Gln Pro Gly Tyr Arg Ser                                           
        355                 360                                           


<210>  6
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 








