                         SEQUENCE LISTING

<110>  Isis Innovation Limited
 
<120>  Therapeutic Antibody

<130>  HB/P41088GB

<160>  36    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  Rattus sp.

<400>  1

Ser Phe Pro Met Ala 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Rattus sp.

<400>  2

Thr Ile Gly Thr Ser Gly Thr Thr Ala Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  9
<212>  PRT
<213>  Rattus sp.

<400>  3

Gly Thr Gly Asn Trp Tyr Leu Asp Leu 
1               5                   


<210>  4
<211>  17
<212>  PRT
<213>  Rattus sp.

<400>  4

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Gly Asn Glu Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  7
<212>  PRT
<213>  Rattus sp.

<400>  5

Trp Ala Phe Thr Arg His Ser 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  6

Gln Gln Tyr Tyr Asp Thr Tyr Thr 
1               5               


<210>  7
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  Ala-ala mutant heavy chain

<400>  7

Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Ile Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Gly Thr Ser Gly Thr Thr Ala Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Ile Ile Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Thr Gly Asn Trp Tyr Leu Asp Leu Trp Gly 
        115                 120                 125             


Pro Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  8
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  Aglycosyl heavy chain

<400>  8

Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Ile Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Gly Thr Ser Gly Thr Thr Ala Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Ile Ile Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Thr Gly Asn Trp Tyr Leu Asp Leu Trp Gly 
        115                 120                 125             


Pro Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  9
<211>  137
<212>  PRT
<213>  Rattus sp.

<400>  9

Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Ile Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Gly Thr Ser Gly Thr Thr Ala Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Ile Ile Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Thr Gly Asn Trp Tyr Leu Asp Leu Trp Gly 
        115                 120                 125             


Pro Gly Thr Met Val Thr Val Ser Ser 
    130                 135         


<210>  10
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Ala-ala mutant constant heavy chain

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Aglycosyl mutant constant heavy chain

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  19
<212>  PRT
<213>  Rattus sp.

<400>  12

Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  13
<211>  30
<212>  PRT
<213>  Rattus sp.

<400>  13

Glu Val Gln Leu Ile Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser 
            20                  25                  30  


<210>  14
<211>  14
<212>  PRT
<213>  Rattus sp.

<400>  14

Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  15
<211>  32
<212>  PRT
<213>  Rattus sp.

<400>  15

Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Ser Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Ile Ile Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  16
<211>  11
<212>  PRT
<213>  Rattus sp.

<400>  16

Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  17
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys 
    


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  19
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Aglycosyl CH2 region

<400>  19

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  20
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  21
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Ala-ala mutant CH2 region

<400>  21

Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  22
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain

<400>  22

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Thr Val Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Gly Asn Glu Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Phe Thr Arg 
65                  70                  75                  80  


His Ser Gly Val Pro Asp Arg Phe Ile Gly Thr Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Asp Thr Tyr Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  23
<211>  133
<212>  PRT
<213>  Rattus sp.

<400>  23

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Thr Val Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Gly Asn Glu Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Phe Thr Arg 
65                  70                  75                  80  


His Ser Gly Val Pro Asp Arg Phe Ile Gly Thr Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Asp Thr Tyr Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg 
    130             


<210>  24
<211>  20
<212>  PRT
<213>  Rattus sp.

<400>  24

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Thr Cys Gly 
            20  


<210>  25
<211>  23
<212>  PRT
<213>  Rattus sp.

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Asn Cys 
            20              


<210>  26
<211>  15
<212>  PRT
<213>  Rattus sp.

<400>  26

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  27
<211>  32
<212>  PRT
<213>  Rattus sp.

<400>  27

Gly Val Pro Asp Arg Phe Ile Gly Thr Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  Rattus sp.

<400>  28

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
1               5                   10      


<210>  29
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  29

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  30
<211>  741
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain

<400>  30
aagcttgccg ccaccatgga atcacagacc caggtcctca tgtccctgct gctctggatt     60

tctggtacct gtggggacat tgtgatgacc caatctccat cctctctggc tgtgtcagca    120

ggagagacgg tcactataaa ctgcaagtcc agtcagagtc ttttatacag tggaaacgaa    180

aagaactact tggcctggta ccagcagaaa ccagggcagt ctcctaaact gctgatctac    240

tgggcattta ctaggcattc tggtgtccct gatcgcttca taggcactgg atctgggaca    300

gacttcactc tgaccatcag cagtgtgcag gcagaagatc tggccattta ttactgtcag    360

cagtattatg atacttacac gtttggagct gggaccaagc tggaactgaa acggactgtg    420

gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc    480

tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg    540

gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac    600

agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa    660

gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac    720

aggggagagt gttgaaagct t                                              741


<210>  31
<211>  1438
<212>  DNA
<213>  Artificial

<220>
<223>  Ala-ala mutant heavy chain

<400>  31
aagcttgccg ccaccatgga catcaggctc agcttggctt tccttgtcct tttcataaaa     60

ggtgtccagt gtgaggtgca gctgatagag tctgggggcg gtttagtgca gcctggaagg    120

tccatgaaac tctcctgtgc agcctcaaga ttcactttca gtagctttcc aatggcctgg    180

gtccgccagg ctccaacgaa gggtctggag tgggtcgcaa ccattggtac tagtggtact    240

actgcttact atcgagactc cgtgaagggc cgattcacta tctccagaga taatgaaaaa    300

agcaccctat acctgcaaat aatcagtctg aggtctgagg acacggccac ttattactgt    360

acaagaggca cggggaactg gtaccttgac ctctggggcc caggaaccat ggtcaccgtg    420

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc    480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg    540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag    600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc    660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt    720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcgcg    780

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg    840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc    900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag    960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat   1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc   1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg   1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc   1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct   1260

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc   1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac   1380

tacacgcaga agagcctctc cctgtctccg ggtaaatgag tgcgacggcc ccgaattc     1438


<210>  32
<211>  131
<212>  PRT
<213>  Hamster sp.

<400>  32

Met Glu Ser His Asn Glu Val Leu Val Thr Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Ala Cys Ala Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Asp Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Ser Gly Gly Tyr Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Thr 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Phe Thr Ser Thr Arg His Thr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Ser Phe Gln Thr Glu Asp Leu Gly Asp Tyr Tyr Cys 
            100                 105                 110         


Gln His His Tyr Gly Thr Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  33
<211>  141
<212>  PRT
<213>  Hamster sp.

<400>  33

Met Val Trp Gly Leu Ile Ile Ile Phe Leu Val Thr Ala Gly Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Phe Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Gly Tyr Met Asn Trp Val Glu Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Asp Ser Gly Asp Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Arg Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Pro Tyr Ile Ala Asp Ile Gly Glu Ala Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210>  34
<211>  106
<212>  PRT
<213>  Rattus rattus

<400>  34

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Met Glu Gln 
1               5                   10                  15      


Leu Thr Ser Gly Gly Ala Thr Val Val Cys Phe Val Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Asp Ile Ser Val Lys Trp Lys Ile Asp Gly Ser Glu Gln Arg 
        35                  40                  45              


Asp Gly Val Leu Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Met Ser Ser Thr Leu Ser Leu Thr Lys Val Glu Tyr Glu Arg 
65                  70                  75                  80  


His Asn Leu Tyr Thr Cys Glu Val Val His Lys Thr Ser Ser Ser Pro 
                85                  90                  95      


Val Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105     


<210>  35
<211>  320
<212>  DNA
<213>  Rattus rattus

<400>  35
gggctgatgc tgcaccaact gtatccatct tcccaccatc catggaacag ttaacatctg     60

gaggtgccac agtcgtgtgc ttcgtgaaca acttctatcc cagagacatc agtgtcaagt    120

ggaagattga tggcagtgaa caacgagatg gtgtcctgga cagtgttact gatcaggaca    180

gcaaagacag cacgtacagc atgagcagca ccctctcgtt gaccaaggtt gaatatgaaa    240

ggcataacct ctatacctgt gaggttgttc ataagacatc atcctcaccc gtcgtcaaga    300

gcttcaacag gaatgagtgt                                                320


<210>  36
<211>  217
<212>  PRT
<213>  Rattus sp.

<400>  36

Val Pro Gln Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Ile Leu Leu Ile Ser Gln Asn Ala Lys Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Glu Glu Pro Asp Val Gln Phe Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Lys Gly Leu 
            100                 105                 110         


Val Arg Lys Pro Gln Val Tyr Val Met Gly Pro Pro Thr Glu Gln Leu 
        115                 120                 125             


Thr Glu Gln Thr Val Ser Leu Thr Cys Leu Thr Ser Gly Phe Leu Pro 
    130                 135                 140                 


Asn Asp Ile Gly Val Glu Trp Thr Ser Asn Gly His Ile Glu Lys Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Met Asp Ser Asp Gly Ser Phe Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Asn Val Glu Arg Ser Arg Trp Asp Ser Arg Ala Pro 
            180                 185                 190         


Phe Val Cys Ser Val Val His Glu Gly Leu His Asn His His Val Glu 
        195                 200                 205             


Lys Ser Ile Ser Arg Pro Pro Gly Lys 
    210                 215         


