                         SEQUENCE LISTING

<110>  Schering Corporation
       Li, Xuhong
       Kashi, Ramesh
       Badkar, Aniket
 
<120>  Lyophilized Formulations of Engineered Anti-IL-23p19 Antibodies

<130>  UB06868

<150>  US 61,092326
<151>  2008-08-27

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Asn Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Ser Arg Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  2

His Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Ala Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Phe Pro Val Arg Gly Ser Ala Asp Tyr Asn Glu Ile Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  3
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Val Asn Ser Tyr Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Tyr Tyr Gly Arg Asn Tyr Gly Asp Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  4
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Leu Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Phe 
            20                  25                  30          


Phe Ile His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn His Asp Val Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Asp 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Asn Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  5
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  5

His Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Glu Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  6
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human frameworks, rodent CDRs


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  Variable Domain

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  7
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human frameworks, rodent CDRs


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  Variable Domain

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  8
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human frameworks, rodent CDRs


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  Variable Domain

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  9
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  9

Asn Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  10
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Trp Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  11
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  11

Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly 
1               5                   10                  15      


Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Ile Thr 
            20                  25                  30          


Ser Asn Asp Ala Asn Trp Val Gln Glu Lys Pro Asp His Ser Phe Thr 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly 
65                  70                  75                  80  


Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  12
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Val Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Phe Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Asp Leu Lys Arg 
            100                 105             


<210>  13
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Arg Tyr Phe Cys Gln His His Tyr Gly Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human frameworks, rodent CDRs


<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  Variable Domain

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  15
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Tyr Ser Phe Thr Ala Tyr Tyr Ile Gln 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  16

Gly Tyr Ile Phe Ser Ala Tyr Trp Met Thr 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Tyr Ser Phe Thr Ser Phe Phe Ile His 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  19

Gly Tyr Ile Phe Ile Thr Tyr Trp Met Thr 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  20

Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Ile Phe Pro Val Arg Gly Ser Ala Asp Tyr Asn Glu Ile Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  22

Glu Ile Tyr Pro Arg Ser Val Asn Ser Tyr Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  23

Trp Ile Phe Pro Gly Asn His Asp Val Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Met Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rodent CDR with one amino acid substitution

<400>  25

Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rodent CDR with four amino acid substitutions

<400>  26

Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  27

Gln Gly Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  28
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Gly Gly Gly Phe Ala Tyr 
1               5           


<210>  29
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  29

Gly Gly Asn Tyr Tyr Gly Arg Asn Tyr Gly Asp Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  30
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  30

Gly Gly Gly Asn Leu Pro Tyr 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Gly Gly Gly Gly Phe Ala Tyr 
1               5           


<210>  32
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  32

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  33
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  33

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  34
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  34

Arg Ser Ser Thr Gly Ala Val Ile Thr Ser Asn Asp Ala Asn 
1               5                   10                  


<210>  35
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  35

Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  36

Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  37

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  38

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  39

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  40

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  41

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  42

Trp Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  43

Gln His His Tyr Gly Thr Pro Phe Thr 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  44

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  45

Gln His His Tyr Gly Ile Pro Phe Thr 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  46

Gln His His Tyr Gly Ile Pro Phe Thr 
1               5                   


<210>  47
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  47

Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys Gln Gln 
1               5                   10                  15      


Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val 
            20                  25                  30          


Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp 
        35                  40                  45              


Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg 
    50                  55                  60                  


Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly Leu Ile Phe 
65                  70                  75                  80  


Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro Ser Leu 
                85                  90                  95      


Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu 
            100                 105                 110         


Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile 
        115                 120                 125             


Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe 
    130                 135                 140                 


Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val 
145                 150                 155                 160 


Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
                165                 170 


<210>  48
<211>  175
<212>  PRT
<213>  Mus musculus

<400>  48

Val Pro Arg Ser Ser Ser Pro Asp Trp Ala Gln Cys Gln Gln Leu Ser 
1               5                   10                  15      


Arg Asn Leu Cys Met Leu Ala Trp Asn Ala His Ala Pro Ala Gly His 
            20                  25                  30          


Met Asn Leu Leu Arg Glu Glu Glu Asp Glu Glu Thr Lys Asn Asn Val 
        35                  40                  45              


Pro Arg Ile Gln Cys Glu Asp Gly Cys Asp Pro Gln Gly Leu Lys Asp 
    50                  55                  60                  


Asn Ser Gln Phe Cys Leu Gln Arg Ile Arg Gln Gly Leu Ala Phe Tyr 
65                  70                  75                  80  


Lys His Leu Leu Asp Ser Asp Ile Phe Lys Gly Glu Pro Ala Leu Leu 
                85                  90                  95      


Pro Asp Ser Pro Met Glu Gln Leu His Thr Ser Leu Leu Gly Leu Ser 
            100                 105                 110         


Gln Leu Leu Gln Pro Glu Asp His Pro Arg Glu Thr Gln Gln Met Pro 
        115                 120                 125             


Ser Leu Ser Ser Ser Gln Gln Trp Gln Arg Pro Leu Leu Arg Ser Lys 
    130                 135                 140                 


Ile Leu Arg Ser Leu Gln Ala Phe Leu Ala Ile Ala Ala Arg Val Phe 
145                 150                 155                 160 


Ala His Gly Ala Ala Thr Leu Thr Glu Pro Leu Val Pro Thr Ala 
                165                 170                 175 


<210>  49
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human constant and framework regions, rodent CDRs

<400>  49
atggctgtgc tggggctgct gttctgcctg gtgacattcc caagctgtgt gctgtcccag       60

gtgcagctgg tgcagtctgg cgctgaggtg aagaagcctg gcgcctccgt gaaggtctcc      120

tgcaaggctt ctggctacat cttcatcacc tactggatga cctgggtgcg gcaggcccct      180

ggccaggggc tggagtggat gggccagatc ttccctgcca gcggctctgc agactacaac      240

gagaagttcg aaggcagagt caccatgacc acagacacat ccaccagcac agcctacatg      300

gagctgagga gcctgagatc tgacgacacc gccgtgtatt actgtgccag aggcggtggc      360

ggattcgctt actggggcca gggcaccctg gtcaccgtct ccagcgctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaatga                                                   1398


<210>  50
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human constant and framework regions, rodent CDRs

<400>  50
atggctccag tgcagctgct ggggctgctg gtgctgttcc tgccagccat gagatgtgat       60

atccagatga cccagtctcc atcctccctg tctgcctctg tgggcgacag agtgaccatc      120

acctgcagga ccagcgagaa catctacagc tacctggcct ggtatcagca gaagccaggg      180

aaggccccta agctgctgat ctataacgcc aagaccctgg ctgaaggggt gccatccagg      240

ttcagcggca gcggctctgg gacagacttc accctgacca tcagcagcct gcagcctgag      300

gacttcgcca cctactactg tcagcaccac tacggaattc cattcacctt cggccagggc      360

accaaggtgg agatcaagcg tacggtggct gcaccatctg tgttcatctt ccctccatct      420

gatgagcagc tgaagtctgg aactgcctcc gtggtgtgcc tgctgaataa cttctatccc      480

agagaggcca aggtgcagtg gaaggtggat aacgccctcc agagcggcaa ctcccaggag      540

agcgtgacag agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      600

agcaaagcag actacgagaa acacaaggtg tacgcctgcg aggtgaccca tcagggcctg      660

agcagccccg tgacaaagag cttcaacagg ggagagtgtt aa                         702


<210>  51
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  51

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser 
            


<210>  52
<211>  19
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys 
            


