                         SEQUENCE LISTING

<110>  Amplimmune, Inc
       Langermann, Solomon
 
<120>  TARGETED COSTIMULATORY POLYPEPTIDES AND METHODS OF USE TO TREAT 
       CANCER AND INFECTIOUS DISEASES

<130>  AMP 224.P1

<150>  US 61/091502
<151>  2008-08-25

<150>  US 61/091694
<151>  2008-08-25

<150>  US 61/091709
<151>  2008-08-25

<150>  US 61/091705
<151>  2008-08-25

<150>  US 61/165652
<151>  2009-04-01

<160>  105   

<170>  PatentIn version 3.3

<210>  1
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  1

Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp Pro Leu His 
    210                 215                 220                 


Val Phe Ile Pro Ala Cys Thr Ile Ala Leu Ile Phe Leu Ala Ile Val 
225                 230                 235                 240 


Ile Ile Gln Arg Lys Arg Ile 
                245         


<210>  2
<211>  228
<212>  PRT
<213>  Mus musculus

<400>  2

Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val Asp Val Gly 
1               5                   10                  15      


Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu Cys Thr Glu 
            20                  25                  30          


Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp Ser Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr Arg Ile Leu 
            100                 105                 110         


Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln Ala Arg Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys Met Phe Trp 
                165                 170                 175     


Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp Pro Leu Ser 
            180                 185                 190         


Arg Met Glu Pro Lys Val Pro Arg Thr Trp Pro Leu His Val Phe Ile 
        195                 200                 205             


Pro Ala Cys Thr Ile Ala Leu Ile Phe Leu Ala Ile Val Ile Ile Gln 
    210                 215                 220                 


Arg Lys Arg Ile 
225             


<210>  3
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  4
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile 
        195                 200                 205             


Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu 
    210                 215                 220                 


Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Thr Thr Lys 
225                 230                 235                 240 


Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala Ile 
                245                 250                 


<210>  5
<211>  273
<212>  PRT
<213>  Macaca fascicularis

<400>  5

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Ala Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  6
<211>  254
<212>  PRT
<213>  Macaca fascicularis

<400>  6

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile 
        195                 200                 205             


Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu 
    210                 215                 220                 


Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Ala Thr Lys 
225                 230                 235                 240 


Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala Ile 
                245                 250                 


<210>  7
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly 
                245                 250                 255     


Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys 
            260                 265                 270         


Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn 
        275                 280                 285             


Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val 
    290                 295                 300                 


Phe Leu 
305     


<210>  8
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  8

Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp Lys Val Leu Leu Pro 
1               5                   10                  15      


Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser Glu Asp Arg Ile Tyr 
            20                  25                  30          


Trp Gln Lys His Asp Lys Val Val Leu Ser Val Ile Ala Gly Lys Leu 
        35                  40                  45              


Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu Tyr Asp Asn Thr Thr 
    50                  55                  60                  


Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser Asp Arg Gly Thr Tyr 
65                  70                  75                  80  


Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr Tyr Glu Val Lys His 
                85                  90                  95      


Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp Phe Ser Thr Pro Asn 
            100                 105                 110         


Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr Lys Arg Ile Thr Cys 
        115                 120                 125             


Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp Phe Asn Thr Thr Arg 
                165                 170                 175     


Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly Asp Ala His Val Ser 
            180                 185                 190         


Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp Pro Pro Asp Ser Lys 
        195                 200                 205             


Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly Ala Val Ile Thr Val 
    210                 215                 220                 


Val Val Ile Val Val Ile Ile Lys Cys Phe Cys Lys His Arg Ser Cys 
225                 230                 235                 240 


Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn Asn Ser Leu Thr Phe 
                245                 250                 255     


Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val Phe Leu 
            260                 265                 


<210>  9
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  10
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    210                 215                 220                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
225                 230                 235                 240 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
                245                 250                 


<210>  11
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  11

Met Asp Pro Arg Cys Thr Met Gly Leu Ala Ile Leu Ile Phe Val Thr 
1               5                   10                  15      


Val Leu Leu Ile Ser Asp Ala Val Ser Val Glu Thr Gln Ala Tyr Phe 
            20                  25                  30          


Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
    50                  55                  60                  


Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
            100                 105                 110         


Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
        115                 120                 125             


Glu Leu Ser Val Ile Ala Asn Phe Ser Glu Pro Glu Ile Lys Leu Ala 
    130                 135                 140                 


Gln Asn Val Thr Gly Asn Ser Gly Ile Asn Leu Thr Cys Thr Ser Lys 
145                 150                 155                 160 


Gln Gly His Pro Lys Pro Lys Lys Met Tyr Phe Leu Ile Thr Asn Ser 
                165                 170                 175     


Thr Asn Glu Tyr Gly Asp Asn Met Gln Ile Ser Gln Asp Asn Val Thr 
            180                 185                 190         


Glu Leu Phe Ser Ile Ser Asn Ser Leu Ser Leu Ser Phe Pro Asp Gly 
        195                 200                 205             


Val Trp His Met Thr Val Val Cys Val Leu Glu Thr Glu Ser Met Lys 
    210                 215                 220                 


Ile Ser Ser Lys Pro Leu Asn Phe Thr Gln Glu Phe Pro Ser Pro Gln 
225                 230                 235                 240 


Thr Tyr Trp Lys Glu Ile Thr Ala Ser Val Thr Val Ala Leu Leu Leu 
                245                 250                 255     


Val Met Leu Leu Ile Ile Val Cys His Lys Lys Pro Asn Gln Pro Ser 
            260                 265                 270         


Arg Pro Ser Asn Thr Ala Ser Lys Leu Glu Arg Asp Ser Asn Ala Asp 
        275                 280                 285             


Arg Glu Thr Ile Asn Leu Lys Glu Leu Glu Pro Gln Ile Ala Ser Ala 
    290                 295                 300                 


Lys Pro Asn Ala Glu 
305                 


<210>  12
<211>  286
<212>  PRT
<213>  Mus musculus

<400>  12

Val Ser Val Glu Thr Gln Ala Tyr Phe Asn Gly Thr Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Pro Phe Thr Lys Ala Gln Asn Ile Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Gln Lys Leu Val Leu Tyr Glu His Tyr Leu Gly 
        35                  40                  45              


Thr Glu Lys Leu Asp Ser Val Asn Ala Lys Tyr Leu Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Arg Asn Asn Trp Thr Leu Arg Leu His Asn Val Gln Ile Lys 
65                  70                  75                  80  


Asp Met Gly Ser Tyr Asp Cys Phe Ile Gln Lys Lys Pro Pro Thr Gly 
                85                  90                  95      


Ser Ile Ile Leu Gln Gln Thr Leu Thr Glu Leu Ser Val Ile Ala Asn 
            100                 105                 110         


Phe Ser Glu Pro Glu Ile Lys Leu Ala Gln Asn Val Thr Gly Asn Ser 
        115                 120                 125             


Gly Ile Asn Leu Thr Cys Thr Ser Lys Gln Gly His Pro Lys Pro Lys 
    130                 135                 140                 


Lys Met Tyr Phe Leu Ile Thr Asn Ser Thr Asn Glu Tyr Gly Asp Asn 
145                 150                 155                 160 


Met Gln Ile Ser Gln Asp Asn Val Thr Glu Leu Phe Ser Ile Ser Asn 
                165                 170                 175     


Ser Leu Ser Leu Ser Phe Pro Asp Gly Val Trp His Met Thr Val Val 
            180                 185                 190         


Cys Val Leu Glu Thr Glu Ser Met Lys Ile Ser Ser Lys Pro Leu Asn 
        195                 200                 205             


Phe Thr Gln Glu Phe Pro Ser Pro Gln Thr Tyr Trp Lys Glu Ile Thr 
    210                 215                 220                 


Ala Ser Val Thr Val Ala Leu Leu Leu Val Met Leu Leu Ile Ile Val 
225                 230                 235                 240 


Cys His Lys Lys Pro Asn Gln Pro Ser Arg Pro Ser Asn Thr Ala Ser 
                245                 250                 255     


Lys Leu Glu Arg Asp Ser Asn Ala Asp Arg Glu Thr Ile Asn Leu Lys 
            260                 265                 270         


Glu Leu Glu Pro Gln Ile Ala Ser Ala Lys Pro Asn Ala Glu 
        275                 280                 285     


<210>  13
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Thr Cys Phe 
            


<210>  14
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
1               5                   10                  15      


Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu 
            20                  25                  30          


Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser 
        35                  40                  45              


Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp 
    50                  55                  60                  


Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln 
65                  70                  75                  80  


Cys Ile Ile His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln 
                85                  90                  95      


Met Asn Ser Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile 
            100                 105                 110         


Val Pro Ile Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys 
        115                 120                 125             


Ser Ser Ile His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu 
    130                 135                 140                 


Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser 
145                 150                 155                 160 


Gln Asp Asn Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val 
                165                 170                 175     


Ser Phe Pro Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu 
            180                 185                 190         


Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu 
        195                 200                 205             


Asp Pro Gln Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu 
    210                 215                 220                 


Pro Thr Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys 
225                 230                 235                 240 


Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                245                 250                 255     


Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile 
            260                 265                 270         


His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser 
        275                 280                 285             


Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    290                 295                 300 


<210>  15
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  15

Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
    50                  55                  60                  


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
                85                  90                  95      


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
            100                 105                 110         


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
        115                 120                 125             


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
    130                 135                 140                 


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
145                 150                 155                 160 


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
                165                 170                 175     


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Ala Ala 
            180                 185                 190         


Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu Pro Leu Ile 
        195                 200                 205             


Leu Leu Leu Val Tyr Lys Gln Arg Gln Val Ala Ser His Arg Arg Ala 
    210                 215                 220                 


Gln Glu Leu Val Arg Met Asp Ser Ser Asn Thr Gln Gly Ile Glu Asn 
225                 230                 235                 240 


Pro Gly Phe Glu Thr Thr Pro Pro Phe Gln Gly Met Pro Glu Ala Lys 
                245                 250                 255     


Thr Arg Pro Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser Glu Ser 
            260                 265                 270         


Gly Arg Tyr Leu Leu Ser Asp Pro Ser Thr Pro Leu Ser Pro Pro Gly 
        275                 280                 285             


Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp Ser Pro 
    290                 295                 300                 


Asn Ser Glu Ala Ile 
305                 


<210>  16
<211>  277
<212>  PRT
<213>  Mus musculus

<400>  16

Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
            20                  25                  30          


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
    50                  55                  60                  


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
65                  70                  75                  80  


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
                85                  90                  95      


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
            100                 105                 110         


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
        115                 120                 125             


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
    130                 135                 140                 


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Ala Ala 
145                 150                 155                 160 


Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu Pro Leu Ile 
                165                 170                 175     


Leu Leu Leu Val Tyr Lys Gln Arg Gln Val Ala Ser His Arg Arg Ala 
            180                 185                 190         


Gln Glu Leu Val Arg Met Asp Ser Ser Asn Thr Gln Gly Ile Glu Asn 
        195                 200                 205             


Pro Gly Phe Glu Thr Thr Pro Pro Phe Gln Gly Met Pro Glu Ala Lys 
    210                 215                 220                 


Thr Arg Pro Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser Glu Ser 
225                 230                 235                 240 


Gly Arg Tyr Leu Leu Ser Asp Pro Ser Thr Pro Leu Ser Pro Pro Gly 
                245                 250                 255     


Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp Ser Pro 
            260                 265                 270         


Asn Ser Glu Ala Ile 
        275         


<210>  17
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  18
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
    130                 135                 140                 


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
145                 150                 155                 160 


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
                165                 170                 175     


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
            180                 185                 190         


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
        195                 200                 205             


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
    210                 215                 220                 


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
225                 230                 235                 240 


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
                245                 250                 255     


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
            260                 265                 270         


Ser Pro Asn Phe Glu Val Ile 
        275                 


<210>  19
<211>  663
<212>  DNA
<213>  Mus musculus

<400>  19
atgctgctcc tgctgccgat actgaacctg agcttacaac ttcatcctgt agcagcttta     60

ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg    120

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag    180

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg    240

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac    300

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaagtcaaa    360

gcttcttaca tgaggataga cactaggatc ctggaggttc caggtacagg ggaggtgcag    420

cttacctgcc aggctagagg ttatccccta gcagaagtgt cctggcaaaa tgtcagtgtt    480

cctgccaaca ccagccacat caggaccccc gaaggcctct accaggtcac cagtgttctg    540

cgcctcaagc ctcagcctag cagaaacttc agctgcatgt tctggaatgc tcacatgaag    600

gagctgactt cagccatcat tgaccctctg agtcggatgg aacccaaagt ccccagaacg    660

tgg                                                                  663


<210>  20
<211>  221
<212>  PRT
<213>  Mus musculus

<400>  20

Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp 
    210                 215                 220     


<210>  21
<211>  202
<212>  PRT
<213>  Mus musculus

<400>  21

Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val Asp Val Gly 
1               5                   10                  15      


Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu Cys Thr Glu 
            20                  25                  30          


Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp Ser Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr Arg Ile Leu 
            100                 105                 110         


Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln Ala Arg Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys Met Phe Trp 
                165                 170                 175     


Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp Pro Leu Ser 
            180                 185                 190         


Arg Met Glu Pro Lys Val Pro Arg Thr Trp 
        195                 200         


<210>  22
<211>  294
<212>  DNA
<213>  Mus musculus

<400>  22
ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg     60

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag    120

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg    180

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac    240

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaa          294


<210>  23
<211>  98
<212>  PRT
<213>  Mus musculus

<400>  23

Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val Asp Val Gly Ser 
1               5                   10                  15      


Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu Cys Thr Glu Leu 
            20                  25                  30          


Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Leu 
        35                  40                  45              


Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp Ser Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Val Lys 
        


<210>  24
<211>  738
<212>  DNA
<213>  Mus musculus

<400>  24
atggcttgca attgtcagtt gatgcaggat acaccactcc tcaagtttcc atgtccaagg     60

ctcattcttc tctttgtgct gctgattcgt ctttcacaag tgtcttcaga tgttgatgaa    120

caactgtcca agtcagtgaa agataaggta ttgctgcctt gccgttacaa ctctcctcat    180

gaagatgagt ctgaagaccg aatctactgg caaaaacatg acaaagtggt gctgtctgtc    240

attgctggga aactaaaagt gtggcccgag tataagaacc ggactttata tgacaacact    300

acctactctc ttatcatcct gggcctggtc ctttcagacc ggggcacata cagctgtgtc    360

gttcaaaaga aggaaagagg aacgtatgaa gttaaacact tggctttagt aaagttgtcc    420

atcaaagctg acttctctac ccccaacata actgagtctg gaaacccatc tgcagacact    480

aaaaggatta cctgctttgc ttccgggggt ttcccaaagc ctcgcttctc ttggttggaa    540

aatggaagag aattacctgg catcaatacg acaatttccc aggatcctga atctgaattg    600

tacaccatta gtagccaact agatttcaat acgactcgca accacaccat taagtgtctc    660

attaaatatg gagatgctca cgtgtcagag gacttcacct gggaaaaacc cccagaagac    720

cctcctgata gcaagaac                                                  738


<210>  25
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  25

Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn 
                245     


<210>  26
<211>  209
<212>  PRT
<213>  Mus musculus

<400>  26

Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp Lys Val Leu Leu Pro 
1               5                   10                  15      


Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser Glu Asp Arg Ile Tyr 
            20                  25                  30          


Trp Gln Lys His Asp Lys Val Val Leu Ser Val Ile Ala Gly Lys Leu 
        35                  40                  45              


Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu Tyr Asp Asn Thr Thr 
    50                  55                  60                  


Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser Asp Arg Gly Thr Tyr 
65                  70                  75                  80  


Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr Tyr Glu Val Lys His 
                85                  90                  95      


Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp Phe Ser Thr Pro Asn 
            100                 105                 110         


Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr Lys Arg Ile Thr Cys 
        115                 120                 125             


Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp Phe Asn Thr Thr Arg 
                165                 170                 175     


Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly Asp Ala His Val Ser 
            180                 185                 190         


Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp Pro Pro Asp Ser Lys 
        195                 200                 205             


Asn 
    


<210>  27
<211>  291
<212>  DNA
<213>  Mus musculus

<400>  27
gttgatgaac aactgtccaa gtcagtgaaa gataaggtat tgctgccttg ccgttacaac     60

tctcctcatg aagatgagtc tgaagaccga atctactggc aaaaacatga caaagtggtg    120

ctgtctgtca ttgctgggaa actaaaagtg tggcccgagt ataagaaccg gactttatat    180

gacaacacta cctactctct tatcatcctg ggcctggtcc tttcagaccg gggcacatac    240

agctgtgtcg ttcaaaagaa ggaaagagga acgtatgaag ttaaacactt g             291


<210>  28
<211>  97
<212>  PRT
<213>  Mus musculus

<400>  28

Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp Lys Val Leu Leu Pro 
1               5                   10                  15      


Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser Glu Asp Arg Ile Tyr 
            20                  25                  30          


Trp Gln Lys His Asp Lys Val Val Leu Ser Val Ile Ala Gly Lys Leu 
        35                  40                  45              


Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu Tyr Asp Asn Thr Thr 
    50                  55                  60                  


Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser Asp Arg Gly Thr Tyr 
65                  70                  75                  80  


Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr Tyr Glu Val Lys His 
                85                  90                  95      


Leu 
    


<210>  29
<211>  732
<212>  DNA
<213>  Mus musculus

<400>  29
atggacccca gatgcaccat gggcttggca atccttatct ttgtgacagt cttgctgatc     60

tcagatgctg tttccgtgga gacgcaagct tatttcaatg ggactgcata tctgccgtgc    120

ccatttacaa aggctcaaaa cataagcctg agtgagctgg tagtattttg gcaggaccag    180

caaaagttgg ttctgtacga gcactatttg ggcacagaga aacttgatag tgtgaatgcc    240

aagtacctgg gccgcacgag ctttgacagg aacaactgga ctctacgact tcacaatgtt    300

cagatcaagg acatgggctc gtatgattgt tttatacaaa aaaagccacc cacaggatca    360

attatcctcc aacagacatt aacagaactg tcagtgatcg ccaacttcag tgaacctgaa    420

ataaaactgg ctcagaatgt aacaggaaat tctggcataa atttgacctg cacgtctaag    480

caaggtcacc cgaaacctaa gaagatgtat tttctgataa ctaattcaac taatgagtat    540

ggtgataaca tgcagatatc acaagataat gtcacagaac tgttcagtat ctccaacagc    600

ctctctcttt cattcccgga tggtgtgtgg catatgaccg ttgtgtgtgt tctggaaacg    660

gagtcaatga agatttcctc caaacctctc aatttcactc aagagtttcc atctcctcaa    720

acgtattgga ag                                                        732


<210>  30
<211>  221
<212>  PRT
<213>  Mus musculus

<400>  30

Val Ser Val Glu Thr Gln Ala Tyr Phe Asn Gly Thr Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Pro Phe Thr Lys Ala Gln Asn Ile Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Gln Lys Leu Val Leu Tyr Glu His Tyr Leu Gly 
        35                  40                  45              


Thr Glu Lys Leu Asp Ser Val Asn Ala Lys Tyr Leu Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Arg Asn Asn Trp Thr Leu Arg Leu His Asn Val Gln Ile Lys 
65                  70                  75                  80  


Asp Met Gly Ser Tyr Asp Cys Phe Ile Gln Lys Lys Pro Pro Thr Gly 
                85                  90                  95      


Ser Ile Ile Leu Gln Gln Thr Leu Thr Glu Leu Ser Val Ile Ala Asn 
            100                 105                 110         


Phe Ser Glu Pro Glu Ile Lys Leu Ala Gln Asn Val Thr Gly Asn Ser 
        115                 120                 125             


Gly Ile Asn Leu Thr Cys Thr Ser Lys Gln Gly His Pro Lys Pro Lys 
    130                 135                 140                 


Lys Met Tyr Phe Leu Ile Thr Asn Ser Thr Asn Glu Tyr Gly Asp Asn 
145                 150                 155                 160 


Met Gln Ile Ser Gln Asp Asn Val Thr Glu Leu Phe Ser Ile Ser Asn 
                165                 170                 175     


Ser Leu Ser Leu Ser Phe Pro Asp Gly Val Trp His Met Thr Val Val 
            180                 185                 190         


Cys Val Leu Glu Thr Glu Ser Met Lys Ile Ser Ser Lys Pro Leu Asn 
        195                 200                 205             


Phe Thr Gln Glu Phe Pro Ser Pro Gln Thr Tyr Trp Lys 
    210                 215                 220     


<210>  31
<211>  221
<212>  PRT
<213>  Mus musculus

<400>  31

Val Ser Val Glu Thr Gln Ala Tyr Phe Asn Gly Thr Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Pro Phe Thr Lys Ala Gln Asn Ile Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Gln Lys Leu Val Leu Tyr Glu His Tyr Leu Gly 
        35                  40                  45              


Thr Glu Lys Leu Asp Ser Val Asn Ala Lys Tyr Leu Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Arg Asn Asn Trp Thr Leu Arg Leu His Asn Val Gln Ile Lys 
65                  70                  75                  80  


Asp Met Gly Ser Tyr Asp Cys Phe Ile Gln Lys Lys Pro Pro Thr Gly 
                85                  90                  95      


Ser Ile Ile Leu Gln Gln Thr Leu Thr Glu Leu Ser Val Ile Ala Asn 
            100                 105                 110         


Phe Ser Glu Pro Glu Ile Lys Leu Ala Gln Asn Val Thr Gly Asn Ser 
        115                 120                 125             


Gly Ile Asn Leu Thr Cys Thr Ser Lys Gln Gly His Pro Lys Pro Lys 
    130                 135                 140                 


Lys Met Tyr Phe Leu Ile Thr Asn Ser Thr Asn Glu Tyr Gly Asp Asn 
145                 150                 155                 160 


Met Gln Ile Ser Gln Asp Asn Val Thr Glu Leu Phe Ser Ile Ser Asn 
                165                 170                 175     


Ser Leu Ser Leu Ser Phe Pro Asp Gly Val Trp His Met Thr Val Val 
            180                 185                 190         


Cys Val Leu Glu Thr Glu Ser Met Lys Ile Ser Ser Lys Pro Leu Asn 
        195                 200                 205             


Phe Thr Gln Glu Phe Pro Ser Pro Gln Thr Tyr Trp Lys 
    210                 215                 220     


<210>  32
<211>  288
<212>  DNA
<213>  Mus musculus

<400>  32
aatgggactg catatctgcc gtgcccattt acaaaggctc aaaacataag cctgagtgag     60

ctggtagtat tttggcagga ccagcaaaag ttggttctgt acgagcacta tttgggcaca    120

gagaaacttg atagtgtgaa tgccaagtac ctgggccgca cgagctttga caggaacaac    180

tggactctac gacttcacaa tgttcagatc aaggacatgg gctcgtatga ttgttttata    240

caaaaaaagc cacccacagg atcaattatc ctccaacaga cattaaca                 288


<210>  33
<211>  96
<212>  PRT
<213>  Mus musculus

<400>  33

Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
1               5                   10                  15      


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
            20                  25                  30          


Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
        35                  40                  45              


Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
    50                  55                  60                  


Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
65                  70                  75                  80  


Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
                85                  90                  95      


<210>  34
<211>  570
<212>  DNA
<213>  Mus musculus

<400>  34
atgggtgtcc ccgcggtccc agaggccagc agcccgcgct ggggaaccct gctccttgct     60

attttcctgg ctgcatccag aggtctggta gcagccttca aggtcaccac tccatattct    120

ctctatgtgt gtcccgaggg acagaatgcc accctcacct gcaggattct gggccccgtg    180

tccaaagggc acgatgtgac catctacaag acgtggtacc tcagctcacg aggcgaggtc    240

cagatgtgca aagaacaccg gcccatacgc aacttcacat tgcagcacct tcagcaccac    300

ggaagccacc tgaaagccaa cgccagccat gaccagcccc agaagcatgg gctagagcta    360

gcttctgacc accacggtaa cttctctatc accctgcgca atgtgacccc aagggacagc    420

ggcctctact gctgtctagt gatagaatta aaaaaccacc acccagaaca acggttctac    480

gggtccatgg agctacaggt acaggcaggc aaaggctcgg ggtccacatg catggcgtct    540

aatgagcagg acagtgacag catcacggct                                     570


<210>  35
<211>  190
<212>  PRT
<213>  Mus musculus

<400>  35

Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
    50                  55                  60                  


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
                85                  90                  95      


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
            100                 105                 110         


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
        115                 120                 125             


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
    130                 135                 140                 


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
145                 150                 155                 160 


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
                165                 170                 175     


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala 
            180                 185                 190 


<210>  36
<211>  158
<212>  PRT
<213>  Mus musculus

<400>  36

Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
            20                  25                  30          


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
    50                  55                  60                  


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
65                  70                  75                  80  


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
                85                  90                  95      


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
            100                 105                 110         


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
        115                 120                 125             


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
    130                 135                 140                 


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala 
145                 150                 155             


<210>  37
<211>  387
<212>  DNA
<213>  Mus musculus

<400>  37
ttcaaggtca ccactccata ttctctctat gtgtgtcccg agggacagaa tgccaccctc     60

acctgcagga ttctgggccc cgtgtccaaa gggcacgatg tgaccatcta caagacgtgg    120

tacctcagct cacgaggcga ggtccagatg tgcaaagaac accggcccat acgcaacttc    180

acattgcagc accttcagca ccacggaagc cacctgaaag ccaacgccag ccatgaccag    240

ccccagaagc atgggctaga gctagcttct gaccaccacg gtaacttctc tatcaccctg    300

cgcaatgtga ccccaaggga cagcggcctc tactgctgtc tagtgataga attaaaaaac    360

caccacccag aacaacggtt ctacggg                                        387


<210>  38
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  38

Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
            20                  25                  30          


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
    50                  55                  60                  


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
65                  70                  75                  80  


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
                85                  90                  95      


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
            100                 105                 110         


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
        115                 120                 125             


Gly 
    


<210>  39
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  39
atgatctttc ttctcttgat gctgtctttg gaattgcaac ttcaccaaat cgcggccctc     60

tttactgtga ccgtgccaaa agaactgtat atcattgagc acgggtccaa tgtgaccctc    120

gaatgtaact ttgacaccgg cagccacgtt aacctggggg ccatcactgc cagcttgcaa    180

aaagttgaaa acgacacttc acctcaccgg gagagggcaa ccctcttgga ggagcaactg    240

ccattgggga aggcctcctt tcatatccct caggtgcagg ttcgggatga gggacagtac    300

cagtgcatta ttatctacgg cgtggcttgg gattacaagt atctgaccct gaaggtgaaa    360

gcgtcctatc ggaaaattaa cactcacatt cttaaggtgc cagagacgga cgaggtggaa    420

ctgacatgcc aagccaccgg ctacccgttg gcagaggtca gctggcccaa cgtgagcgta    480

cctgctaaca cttctcattc taggacaccc gagggcctct accaggttac atccgtgctc    540

cgcctcaaac cgcccccagg ccggaatttt agttgcgtgt tttggaatac ccacgtgcga    600

gagctgactc ttgcatctat tgatctgcag tcccagatgg agccacggac tcatccaact    660

tgg                                                                  663


<210>  40
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp 
    210                 215                 220     


<210>  41
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp 
        195                 200         


<210>  42
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  42
tttactgtga ccgtgccaaa agaactgtat atcattgagc acgggtccaa tgtgaccctc     60

gaatgtaact ttgacaccgg cagccacgtt aacctggggg ccatcactgc cagcttgcaa    120

aaagttgaaa acgacacttc acctcaccgg gagagggcaa ccctcttgga ggagcaactg    180

ccattgggga aggcctcctt tcatatccct caggtgcagg ttcgggatga gggacagtac    240

cagtgcatta ttatctacgg cgtggcttgg gattacaagt atctgaccct gaag          294


<210>  43
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  43

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  44
<211>  732
<212>  DNA
<213>  Homo sapiens

<400>  44
atgggccaca cacggaggca gggaacatca ccatccaagt gtccatacct caatttcttt     60

cagctcttgg tgctggctgg tctttctcac ttctgttcag gtgttatcca cgtgaccaag    120

gaagtgaaag aagtggcaac gctgtcctgt ggtcacaatg tttctgttga agagctggca    180

caaactcgca tctactggca aaaggagaag aaaatggtgc tgactatgat gtctggggac    240

atgaatatat ggcccgagta caagaaccgg accatctttg atatcactaa taacctctcc    300

attgtgatcc tggctctgcg cccatctgac gagggcacat acgagtgtgt tgttctgaag    360

tatgaaaaag acgctttcaa gcgggaacac ctggctgaag tgacgttatc agtcaaagct    420

gacttcccta cacctagtat atctgacttt gaaattccaa cttctaatat tagaaggata    480

atttgctcaa cctctggagg ttttccagag cctcacctct cctggttgga aaatggagaa    540

gaattaaatg ccatcaacac aacagtttcc caagatcctg aaactgagct ctatgctgtt    600

agcagcaaac tggatttcaa tatgacaacc aaccacagct tcatgtgtct catcaagtat    660

ggacatttaa gagtgaatca gaccttcaac tggaatacaa ccaagcaaga gcattttcct    720

gataacctgc tc                                                        732


<210>  45
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu 
            


<210>  46
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Leu 
    


<210>  47
<211>  303
<212>  DNA
<213>  Homo sapiens

<400>  47
gttatccacg tgaccaagga agtgaaagaa gtggcaacgc tgtcctgtgg tcacaatgtt     60

tctgttgaag agctggcaca aactcgcatc tactggcaaa aggagaagaa aatggtgctg    120

actatgatgt ctggggacat gaatatatgg cccgagtaca agaaccggac catctttgat    180

atcactaata acctctccat tgtgatcctg gctctgcgcc catctgacga gggcacatac    240

gagtgtgttg ttctgaagta tgaaaaagac gctttcaagc gggaacacct ggctgaagtg    300

acg                                                                  303


<210>  48
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  48

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  49
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  49
atgggactga gtaacattct ctttgtgatg gccttcctgc tctctggtgc tgctcctctg     60

aagattcaag cttatttcaa tgagactgca gacctgccat gccaatttgc aaactctcaa    120

aaccaaagcc tgagtgagct agtagtattt tggcaggacc aggaaaactt ggttctgaat    180

gaggtatact taggcaaaga gaaatttgac agtgttcatt ccaagtatat gggccgcaca    240

agttttgatt cggacagttg gaccctgaga cttcacaatc ttcagatcaa ggacaagggc    300

ttgtatcaat gtatcatcca tcacaaaaag cccacaggaa tgattcgcat ccaccagatg    360

aattctgaac tgtcagtgct tgctaacttc agtcaacctg aaatagtacc aatttctaat    420

ataacagaaa atgtgtacat aaatttgacc tgctcatcta tacacggtta cccagaacct    480

aagaagatga gtgttttgct aagaaccaag aattcaacta tcgagtatga tggtgttatg    540

cagaaatctc aagataatgt cacagaactg tacgacgttt ccatcagctt gtctgtttca    600

ttccctgatg ttacgagcaa tatgaccatc ttctgtattc tggaaactga caagacgcgg    660

cttttatctt cacctttctc tatagagctt gaggaccctc agcctccccc agaccacatt    720

ccttggatta cagctgtact t                                              741


<210>  50
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu 
                245         


<210>  51
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
1               5                   10                  15      


Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu 
            20                  25                  30          


Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser 
        35                  40                  45              


Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp 
    50                  55                  60                  


Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln 
65                  70                  75                  80  


Cys Ile Ile His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln 
                85                  90                  95      


Met Asn Ser Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile 
            100                 105                 110         


Val Pro Ile Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys 
        115                 120                 125             


Ser Ser Ile His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu 
    130                 135                 140                 


Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser 
145                 150                 155                 160 


Gln Asp Asn Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val 
                165                 170                 175     


Ser Phe Pro Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu 
            180                 185                 190         


Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu 
        195                 200                 205             


Asp Pro Gln Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu 
    210                 215                 220                 


<210>  52
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  52
ccatgccaat ttgcaaactc tcaaaaccaa agcctgagtg agctagtagt attttggcag     60

gaccaggaaa acttggttct gaatgaggta tacttaggca aagagaaatt tgacagtgtt    120

cattccaagt atatgggccg cacaagtttt gattcggaca gttggaccct gagacttcac    180

aatcttcaga tcaaggacaa gggcttgtat caatgtatca tccatcacaa aaagcccaca    240

ggaatgattc gcatccacca gatgaattct gaactgtcag tgcttgctaa cttc          294


<210>  53
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  53

Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
1               5                   10                  15      


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
            20                  25                  30          


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
        35                  40                  45              


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
    50                  55                  60                  


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
65                  70                  75                  80  


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
                85                  90                  95      


Asn Phe 
        


<210>  54
<211>  579
<212>  DNA
<213>  Homo sapiens

<400>  54
atgggcgtcc ccacggccct ggaggccggc agctggcgct ggggatccct gctcttcgct     60

ctcttcctgg ctgcgtccct aggtccggtg gcagccttca aggtcgccac gccgtattcc    120

ctgtatgtct gtcccgaggg gcagaacgtc accctcacct gcaggctctt gggccctgtg    180

gacaaagggc acgatgtgac cttctacaag acgtggtacc gcagctcgag gggcgaggtg    240

cagacctgct cagagcgccg gcccatccgc aacctcacgt tccaggacct tcacctgcac    300

catggaggcc accaggctgc caacaccagc cacgacctgg ctcagcgcca cgggctggag    360

tcggcctccg accaccatgg caacttctcc atcaccatgc gcaacctgac cctgctggat    420

agcggcctct actgctgcct ggtggtggag atcaggcacc accactcgga gcacagggtc    480

catggtgcca tggagctgca ggtgcagaca ggcaaagatg caccatccaa ctgtgtggtg    540

tacccatcct cctcccagga tagtgaaaac atcacggct                           579


<210>  55
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala 
    


<210>  56
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  56

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
    130                 135                 140                 


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
145                 150                 155                 160 


Ala 
    


<210>  57
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  57
ttcaaggtcg ccacgccgta ttccctgtat gtctgtcccg aggggcagaa cgtcaccctc     60

acctgcaggc tcttgggccc tgtggacaaa gggcacgatg tgaccttcta caagacgtgg    120

taccgcagct cgaggggcga ggtgcagacc tgctcagagc gccggcccat ccgcaacctc    180

acgttccagg accttcacct gcaccatgga ggccaccagg ctgccaacac cagccacgac    240

ctggctcagc gccacgggct ggagtcggcc tccgaccacc atggcaactt ctccatcacc    300

atgcgcaacc tgaccctgct ggatagcggc ctctactgct gcctggtggt ggagatcagg    360

caccaccact cggagcacag ggtccatggt                                     390


<210>  58
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  58

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly 
    130 


<210>  59
<211>  663
<212>  DNA
<213>  Macaca fascicularis

<400>  59
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta     60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg    120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa    180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg    240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac    300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa    360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag    420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt    480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg    540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg    600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact    660

tgg                                                                  663


<210>  60
<211>  221
<212>  PRT
<213>  Macaca fascicularis

<400>  60

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp 
    210                 215                 220     


<210>  61
<211>  202
<212>  PRT
<213>  Macaca fascicularis

<400>  61

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp 
        195                 200         


<210>  62
<211>  294
<212>  DNA
<213>  Macaca fascicularis

<400>  62
ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg     60

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa    120

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg    180

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac    240

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaa          294


<210>  63
<211>  98
<212>  PRT
<213>  Macaca fascicularis

<400>  63

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  64
<211>  221
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthettic extracellular domain of human B7-DC with a K113S 
       substitution and a signal peptide

<400>  64

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Ser Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp 
    210                 215                 220     


<210>  65
<211>  202
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthettic extracellular domain of human B7-DC with a K113S 
       substitution

<400>  65

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Ser Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp 
        195                 200         


<210>  66
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic IgV domain of human B7-DC with a K113S substitution

<400>  66

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Ser Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  67
<211>  221
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic extracellular domain of human B7-DC with a D111S 
       substitution with signal sequence

<400>  67

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Ser Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp 
    210                 215                 220     


<210>  68
<211>  202
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic extracellular domain of human B7-DC with a D111S 
       substitution

<400>  68

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Ser Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp 
        195                 200         


<210>  69
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic IgV domain of human B7-DC with a D111S substitution

<400>  69

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Ser Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  70
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  70
gagcctaagt catgtgacaa gacccatacg tgcccaccct gtcccgctcc agaactgctg     60

gggggaccta gcgttttctt gttcccccca aagcccaagg acaccctcat gatctcacgg    120

actcccgaag taacatgcgt agtagtcgac gtgagccacg aggatcctga agtgaagttt    180

aattggtacg tggacggagt cgaggtgcat aatgccaaaa ctaaacctcg ggaggagcag    240

tataacagta cctaccgcgt ggtatccgtc ttgacagtgc tccaccagga ctggctgaat    300

ggtaaggagt ataaatgcaa ggtcagcaac aaagctcttc ccgccccaat tgaaaagact    360

atcagcaagg ccaagggaca accccgcgag ccccaggttt acacccttcc accttcacga    420

gacgagctga ccaagaacca ggtgtctctg acttgtctgg tcaaaggttt ctatccttcc    480

gacatcgcag tggagtggga gtcaaacggg cagcctgaga ataactacaa gaccacaccc    540

ccagtgcttg atagcgatgg gagctttttc ctctacagta agctgactgt ggacaaatcc    600

cgctggcagc agggaaacgt tttctcttgt agcgtcatgc atgaggccct ccacaaccat    660

tatactcaga aaagcctgag tctgagtccc ggcaaa                              696


<210>  71
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  71

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  72
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  72
gagccaagag gtcctacgat caagccctgc ccgccttgta aatgcccagc tccaaatttg     60

ctgggtggac cgtcagtctt tatcttcccg ccaaagataa aggacgtctt gatgattagt    120

ctgagcccca tcgtgacatg cgttgtggtg gatgtttcag aggatgaccc cgacgtgcaa    180

atcagttggt tcgttaacaa cgtggaggtg cataccgctc aaacccagac ccacagagag    240

gattataaca gcaccctgcg ggtagtgtcc gccctgccga tccagcatca ggattggatg    300

agcgggaaag agttcaagtg taaggtaaac aacaaagatc tgccagcgcc gattgaacga    360

accattagca agccgaaagg gagcgtgcgc gcacctcagg tttacgtcct tcctccacca    420

gaagaggaga tgacgaaaaa gcaggtgacc ctgacatgca tggtaactga ctttatgcca    480

gaagatattt acgtggaatg gactaataac ggaaagacag agctcaatta caagaacact    540

gagcctgttc tggattctga tggcagctac tttatgtact ccaaattgag ggtcgagaag    600

aagaattggg tcgagagaaa cagttatagt tgctcagtgg tgcatgaggg cctccataat    660

catcacacca caaagtcctt cagccgaacg cccgggaaa                           699


<210>  73
<211>  233
<212>  PRT
<213>  Mus musculus

<400>  73

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  74
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic flexible peptide

<400>  74

Gly Ser Gly Ser 
1               


<210>  75
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic flexible peptide

<400>  75

Gly Gly Gly Ser 
1               


<210>  76
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic flexible peptide

<400>  76

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  77
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic flexible peptide

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  78

<400>  78
000

<210>  79
<211>  1365
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleotide encoding murine B7-DC fusion protein

<400>  79
atgctgctcc tgctgccgat actgaacctg agcttacaac ttcatcctgt agcagcttta     60

ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg    120

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag    180

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg    240

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac    300

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaagtcaaa    360

gcttcttaca tgaggataga cactaggatc ctggaggttc caggtacagg ggaggtgcag    420

cttacctgcc aggctagagg ttatccccta gcagaagtgt cctggcaaaa tgtcagtgtt    480

cctgccaaca ccagccacat caggaccccc gaaggcctct accaggtcac cagtgttctg    540

cgcctcaagc ctcagcctag cagaaacttc agctgcatgt tctggaatgc tcacatgaag    600

gagctgactt cagccatcat tgaccctctg agtcggatgg aacccaaagt ccccagaacg    660

tgggagccaa gaggtcctac gatcaagccc tgcccgcctt gtaaatgccc agctccaaat    720

ttgctgggtg gaccgtcagt ctttatcttc ccgccaaaga taaaggacgt cttgatgatt    780

agtctgagcc ccatcgtgac atgcgttgtg gtggatgttt cagaggatga ccccgacgtg    840

caaatcagtt ggttcgttaa caacgtggag gtgcataccg ctcaaaccca gacccacaga    900

gaggattata acagcaccct gcgggtagtg tccgccctgc cgatccagca tcaggattgg    960

atgagcggga aagagttcaa gtgtaaggta aacaacaaag atctgccagc gccgattgaa   1020

cgaaccatta gcaagccgaa agggagcgtg cgcgcacctc aggtttacgt ccttcctcca   1080

ccagaagagg agatgacgaa aaagcaggtg accctgacat gcatggtaac tgactttatg   1140

ccagaagata tttacgtgga atggactaat aacggaaaga cagagctcaa ttacaagaac   1200

actgagcctg ttctggattc tgatggcagc tactttatgt actccaaatt gagggtcgag   1260

aagaagaatt gggtcgagag aaacagttat agttgctcag tggtgcatga gggcctccat   1320

aatcatcaca ccacaaagtc cttcagccga acgcccggga aatga                   1365


<210>  80
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-DC fusion protein with signal peptide

<400>  80

Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp Glu Pro Arg 
    210                 215                 220                 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
    370                 375                 380                 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
        435                 440                 445             


Ser Arg Thr Pro Gly Lys 
    450                 


<210>  81
<211>  435
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic  murine B7-DC fusion protein

<400>  81

Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val Asp Val Gly 
1               5                   10                  15      


Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu Cys Thr Glu 
            20                  25                  30          


Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp Ser Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr Arg Ile Leu 
            100                 105                 110         


Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln Ala Arg Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys Met Phe Trp 
                165                 170                 175     


Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp Pro Leu Ser 
            180                 185                 190         


Arg Met Glu Pro Lys Val Pro Arg Thr Trp Glu Pro Arg Gly Pro Thr 
        195                 200                 205             


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
    210                 215                 220                 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
225                 230                 235                 240 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
                245                 250                 255     


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
            260                 265                 270         


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
        275                 280                 285             


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
    290                 295                 300                 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
305                 310                 315                 320 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
                325                 330                 335     


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
            340                 345                 350         


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
        355                 360                 365             


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
385                 390                 395                 400 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
                405                 410                 415     


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
            420                 425                 430         


Pro Gly Lys 
        435 


<210>  82
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleotide encoding human B7-DC fusion protein

<400>  82
atgatctttc ttctcttgat gctgtctttg gaattgcaac ttcaccaaat cgcggccctc     60

tttactgtga ccgtgccaaa agaactgtat atcattgagc acgggtccaa tgtgaccctc    120

gaatgtaact ttgacaccgg cagccacgtt aacctggggg ccatcactgc cagcttgcaa    180

aaagttgaaa acgacacttc acctcaccgg gagagggcaa ccctcttgga ggagcaactg    240

ccattgggga aggcctcctt tcatatccct caggtgcagg ttcgggatga gggacagtac    300

cagtgcatta ttatctacgg cgtggcttgg gattacaagt atctgaccct gaaggtgaaa    360

gcgtcctatc ggaaaattaa cactcacatt cttaaggtgc cagagacgga cgaggtggaa    420

ctgacatgcc aagccaccgg ctacccgttg gcagaggtca gctggcccaa cgtgagcgta    480

cctgctaaca cttctcattc taggacaccc gagggcctct accaggttac atccgtgctc    540

cgcctcaaac cgcccccagg ccggaatttt agttgcgtgt tttggaatac ccacgtgcga    600

gagctgactc ttgcatctat tgatctgcag tcccagatgg agccacggac tcatccaact    660

tgggaaccta aatcttgcga taaaactcat acctgtcccc cttgcccagc ccccgagctt    720

ctgggaggtc ccagtgtgtt tctgtttccc ccaaaaccta aggacacact tatgatatcc    780

cgaacgccgg aagtgacatg cgtggttgtg gacgtctcac acgaagaccc ggaggtgaaa    840

ttcaactggt acgttgacgg agttgaggtt cataacgcta agaccaagcc cagagaggag    900

caatacaatt ccacctatcg agtggttagt gtactgaccg ttttgcacca agactggctg    960

aatggaaaag aatacaagtg caaagtatca aacaaggctt tgcctgcacc catcgagaag   1020

acaatttcta aagccaaagg gcagcccagg gaaccgcagg tgtacacact cccaccatcc   1080

cgcgacgagc tgacaaagaa tcaagtatcc ctgacctgcc tggtgaaagg cttttaccca   1140

tctgacattg ccgtggaatg ggaatcaaat ggacaacctg agaacaacta caaaaccact   1200

ccacctgtgc ttgacagcga cgggtccttt ttcctgtaca gtaagctcac tgtcgataag   1260

tctcgctggc agcagggcaa cgtcttttca tgtagtgtga tgcacgaagc tctgcacaac   1320

cattacaccc agaagtctct gtcactgagc ccaggtaaat ga                      1362


<210>  83
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-DC fusion protein with signal peptide

<400>  83

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  84
<211>  434
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic  human B7-DC fusion protein

<400>  84

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Glu Pro Lys Ser Cys Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys 
        


<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88
<211>  1437
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucliec acid encoding murine B7-1 fusion protein

<400>  88
atggcttgca attgtcagtt gatgcaggat acaccactcc tcaagtttcc atgtccaagg     60

ctcattcttc tctttgtgct gctgattcgt ctttcacaag tgtcttcaga tgttgatgaa    120

caactgtcca agtcagtgaa agataaggta ttgctgcctt gccgttacaa ctctcctcat    180

gaagatgagt ctgaagaccg aatctactgg caaaaacatg acaaagtggt gctgtctgtc    240

attgctggga aactaaaagt gtggcccgag tataagaacc ggactttata tgacaacact    300

acctactctc ttatcatcct gggcctggtc ctttcagacc ggggcacata cagctgtgtc    360

gttcaaaaga aggaaagagg aacgtatgaa gttaaacact tggctttagt aaagttgtcc    420

atcaaagctg acttctctac ccccaacata actgagtctg gaaacccatc tgcagacact    480

aaaaggatta cctgctttgc ttccgggggt ttcccaaagc ctcgcttctc ttggttggaa    540

aatggaagag aattacctgg catcaatacg acaatttccc aggatcctga atctgaattg    600

tacaccatta gtagccaact agatttcaat acgactcgca accacaccat taagtgtctc    660

attaaatatg gagatgctca cgtgtcagag gacttcacct gggaaaaacc cccagaagac    720

cctcctgata gcaagaacga gccaagaggt cctacgatca agccctgccc gccttgtaaa    780

tgcccagctc caaatttgct gggtggaccg tcagtcttta tcttcccgcc aaagataaag    840

gacgtcttga tgattagtct gagccccatc gtgacatgcg ttgtggtgga tgtttcagag    900

gatgaccccg acgtgcaaat cagttggttc gttaacaacg tggaggtgca taccgctcaa    960

acccagaccc acagagagga ttataacagc accctgcggg tagtgtccgc cctgccgatc   1020

cagcatcagg attggatgag cgggaaagag ttcaagtgta aggtaaacaa caaagatctg   1080

ccagcgccga ttgaacgaac cattagcaag ccgaaaggga gcgtgcgcgc acctcaggtt   1140

tacgtccttc ctccaccaga agaggagatg acgaaaaagc aggtgaccct gacatgcatg   1200

gtaactgact ttatgccaga agatatttac gtggaatgga ctaataacgg aaagacagag   1260

ctcaattaca agaacactga gcctgttctg gattctgatg gcagctactt tatgtactcc   1320

aaattgaggg tcgagaagaa gaattgggtc gagagaaaca gttatagttg ctcagtggtg   1380

catgagggcc tccataatca tcacaccaca aagtccttca gccgaacgcc cgggaaa      1437


<210>  89
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-1 fusion protein with signal peptide

<400>  89

Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
                245                 250                 255     


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        275                 280                 285             


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    290                 295                 300                 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                325                 330                 335     


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        355                 360                 365             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    370                 375                 380                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
385                 390                 395                 400 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                405                 410                 415     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        435                 440                 445             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475                 


<210>  90
<211>  442
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-1 fusion protein

<400>  90

Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp Lys Val Leu Leu Pro 
1               5                   10                  15      


Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser Glu Asp Arg Ile Tyr 
            20                  25                  30          


Trp Gln Lys His Asp Lys Val Val Leu Ser Val Ile Ala Gly Lys Leu 
        35                  40                  45              


Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu Tyr Asp Asn Thr Thr 
    50                  55                  60                  


Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser Asp Arg Gly Thr Tyr 
65                  70                  75                  80  


Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr Tyr Glu Val Lys His 
                85                  90                  95      


Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp Phe Ser Thr Pro Asn 
            100                 105                 110         


Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr Lys Arg Ile Thr Cys 
        115                 120                 125             


Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp Phe Asn Thr Thr Arg 
                165                 170                 175     


Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly Asp Ala His Val Ser 
            180                 185                 190         


Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp Pro Pro Asp Ser Lys 
        195                 200                 205             


Asn Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
    210                 215                 220                 


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
            260                 265                 270         


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
        275                 280                 285             


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
    290                 295                 300                 


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
305                 310                 315                 320 


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
                325                 330                 335     


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
            340                 345                 350         


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
        355                 360                 365             


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
                405                 410                 415     


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440         


<210>  91
<211>  1425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleic acid encoding  human B7-1 fusion protein

<400>  91
atgggccaca cacggaggca gggaacatca ccatccaagt gtccatacct caatttcttt     60

cagctcttgg tgctggctgg tctttctcac ttctgttcag gtgttatcca cgtgaccaag    120

gaagtgaaag aagtggcaac gctgtcctgt ggtcacaatg tttctgttga agagctggca    180

caaactcgca tctactggca aaaggagaag aaaatggtgc tgactatgat gtctggggac    240

atgaatatat ggcccgagta caagaaccgg accatctttg atatcactaa taacctctcc    300

attgtgatcc tggctctgcg cccatctgac gagggcacat acgagtgtgt tgttctgaag    360

tatgaaaaag acgctttcaa gcgggaacac ctggctgaag tgacgttatc agtcaaagct    420

gacttcccta cacctagtat atctgacttt gaaattccaa cttctaatat tagaaggata    480

atttgctcaa cctctggagg ttttccagag cctcacctct cctggttgga aaatggagaa    540

gaattaaatg ccatcaacac aacagtttcc caagatcctg aaactgagct ctatgctgtt    600

agcagcaaac tggatttcaa tatgacaacc aaccacagct tcatgtgtct catcaagtat    660

ggacatttaa gagtgaatca gaccttcaac tggaatacaa ccaagcaaga gcattttcct    720

gataacctgg agcctaagtc atgtgacaag acccatacgt gcccaccctg tcccgctcca    780

gaactgctgg ggggacctag cgttttcttg ttccccccaa agcccaagga caccctcatg    840

atctcacgga ctcccgaagt aacatgcgta gtagtcgacg tgagccacga ggatcctgaa    900

gtgaagttta attggtacgt ggacggagtc gaggtgcata atgccaaaac taaacctcgg    960

gaggagcagt ataacagtac ctaccgcgtg gtatccgtct tgacagtgct ccaccaggac   1020

tggctgaatg gtaaggagta taaatgcaag gtcagcaaca aagctcttcc cgccccaatt   1080

gaaaagacta tcagcaaggc caagggacaa ccccgcgagc cccaggttta cacccttcca   1140

ccttcacgag acgagctgac caagaaccag gtgtctctga cttgtctggt caaaggtttc   1200

tatccttccg acatcgcagt ggagtgggag tcaaacgggc agcctgagaa taactacaag   1260

accacacccc cagtgcttga tagcgatggg agctttttcc tctacagtaa gctgactgtg   1320

gacaaatccc gctggcagca gggaaacgtt ttctcttgta gcgtcatgca tgaggccctc   1380

cacaaccatt atactcagaa aagcctgagt ctgagtcccg gcaaa                   1425


<210>  92
<211>  475
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-1 fusion protein with signal peptide

<400>  92

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  93
<211>  441
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-1 fusion protein

<400>  93

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  94
<211>  1431
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid encoding  murine B7-2 fusion protein

<400>  94
atggacccca gatgcaccat gggcttggca atccttatct ttgtgacagt cttgctgatc     60

tcagatgctg tttccgtgga gacgcaagct tatttcaatg ggactgcata tctgccgtgc    120

ccatttacaa aggctcaaaa cataagcctg agtgagctgg tagtattttg gcaggaccag    180

caaaagttgg ttctgtacga gcactatttg ggcacagaga aacttgatag tgtgaatgcc    240

aagtacctgg gccgcacgag ctttgacagg aacaactgga ctctacgact tcacaatgtt    300

cagatcaagg acatgggctc gtatgattgt tttatacaaa aaaagccacc cacaggatca    360

attatcctcc aacagacatt aacagaactg tcagtgatcg ccaacttcag tgaacctgaa    420

ataaaactgg ctcagaatgt aacaggaaat tctggcataa atttgacctg cacgtctaag    480

caaggtcacc cgaaacctaa gaagatgtat tttctgataa ctaattcaac taatgagtat    540

ggtgataaca tgcagatatc acaagataat gtcacagaac tgttcagtat ctccaacagc    600

ctctctcttt cattcccgga tggtgtgtgg catatgaccg ttgtgtgtgt tctggaaacg    660

gagtcaatga agatttcctc caaacctctc aatttcactc aagagtttcc atctcctcaa    720

acgtattgga aggagccaag aggtcctacg atcaagccct gcccgccttg taaatgccca    780

gctccaaatt tgctgggtgg accgtcagtc tttatcttcc cgccaaagat aaaggacgtc    840

ttgatgatta gtctgagccc catcgtgaca tgcgttgtgg tggatgtttc agaggatgac    900

cccgacgtgc aaatcagttg gttcgttaac aacgtggagg tgcataccgc tcaaacccag    960

acccacagag aggattataa cagcaccctg cgggtagtgt ccgccctgcc gatccagcat   1020

caggattgga tgagcgggaa agagttcaag tgtaaggtaa acaacaaaga tctgccagcg   1080

ccgattgaac gaaccattag caagccgaaa gggagcgtgc gcgcacctca ggtttacgtc   1140

cttcctccac cagaagagga gatgacgaaa aagcaggtga ccctgacatg catggtaact   1200

gactttatgc cagaagatat ttacgtggaa tggactaata acggaaagac agagctcaat   1260

tacaagaaca ctgagcctgt tctggattct gatggcagct actttatgta ctccaaattg   1320

agggtcgaga agaagaattg ggtcgagaga aacagttata gttgctcagt ggtgcatgag   1380

ggcctccata atcatcacac cacaaagtcc ttcagccgaa cgcccgggaa a            1431


<210>  95
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-2 fusion protein with signal sequence

<400>  95

Met Asp Pro Arg Cys Thr Met Gly Leu Ala Ile Leu Ile Phe Val Thr 
1               5                   10                  15      


Val Leu Leu Ile Ser Asp Ala Val Ser Val Glu Thr Gln Ala Tyr Phe 
            20                  25                  30          


Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
    50                  55                  60                  


Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
            100                 105                 110         


Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
        115                 120                 125             


Glu Leu Ser Val Ile Ala Asn Phe Ser Glu Pro Glu Ile Lys Leu Ala 
    130                 135                 140                 


Gln Asn Val Thr Gly Asn Ser Gly Ile Asn Leu Thr Cys Thr Ser Lys 
145                 150                 155                 160 


Gln Gly His Pro Lys Pro Lys Lys Met Tyr Phe Leu Ile Thr Asn Ser 
                165                 170                 175     


Thr Asn Glu Tyr Gly Asp Asn Met Gln Ile Ser Gln Asp Asn Val Thr 
            180                 185                 190         


Glu Leu Phe Ser Ile Ser Asn Ser Leu Ser Leu Ser Phe Pro Asp Gly 
        195                 200                 205             


Val Trp His Met Thr Val Val Cys Val Leu Glu Thr Glu Ser Met Lys 
    210                 215                 220                 


Ile Ser Ser Lys Pro Leu Asn Phe Thr Gln Glu Phe Pro Ser Pro Gln 
225                 230                 235                 240 


Thr Tyr Trp Lys Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
                245                 250                 255     


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
            260                 265                 270         


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
    290                 295                 300                 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
305                 310                 315                 320 


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
                325                 330                 335     


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
            340                 345                 350         


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
        355                 360                 365             


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
    370                 375                 380                 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
385                 390                 395                 400 


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
                405                 410                 415     


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
        435                 440                 445             


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
    450                 455                 460                 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475         


<210>  96
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-2 fusion protein

<400>  96

Val Ser Val Glu Thr Gln Ala Tyr Phe Asn Gly Thr Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Pro Phe Thr Lys Ala Gln Asn Ile Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Gln Lys Leu Val Leu Tyr Glu His Tyr Leu Gly 
        35                  40                  45              


Thr Glu Lys Leu Asp Ser Val Asn Ala Lys Tyr Leu Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Arg Asn Asn Trp Thr Leu Arg Leu His Asn Val Gln Ile Lys 
65                  70                  75                  80  


Asp Met Gly Ser Tyr Asp Cys Phe Ile Gln Lys Lys Pro Pro Thr Gly 
                85                  90                  95      


Ser Ile Ile Leu Gln Gln Thr Leu Thr Glu Leu Ser Val Ile Ala Asn 
            100                 105                 110         


Phe Ser Glu Pro Glu Ile Lys Leu Ala Gln Asn Val Thr Gly Asn Ser 
        115                 120                 125             


Gly Ile Asn Leu Thr Cys Thr Ser Lys Gln Gly His Pro Lys Pro Lys 
    130                 135                 140                 


Lys Met Tyr Phe Leu Ile Thr Asn Ser Thr Asn Glu Tyr Gly Asp Asn 
145                 150                 155                 160 


Met Gln Ile Ser Gln Asp Asn Val Thr Glu Leu Phe Ser Ile Ser Asn 
                165                 170                 175     


Ser Leu Ser Leu Ser Phe Pro Asp Gly Val Trp His Met Thr Val Val 
            180                 185                 190         


Cys Val Leu Glu Thr Glu Ser Met Lys Ile Ser Ser Lys Pro Leu Asn 
        195                 200                 205             


Phe Thr Gln Glu Phe Pro Ser Pro Gln Thr Tyr Trp Lys Glu Pro Arg 
    210                 215                 220                 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
    370                 375                 380                 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
        435                 440                 445             


Ser Arg Thr Pro Gly Lys 
    450                 


<210>  97
<211>  1437
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleotide encoding  human B7-2 fusion protein

<400>  97
atgggactga gtaacattct ctttgtgatg gccttcctgc tctctggtgc tgctcctctg     60

aagattcaag cttatttcaa tgagactgca gacctgccat gccaatttgc aaactctcaa    120

aaccaaagcc tgagtgagct agtagtattt tggcaggacc aggaaaactt ggttctgaat    180

gaggtatact taggcaaaga gaaatttgac agtgttcatt ccaagtatat gggccgcaca    240

agttttgatt cggacagttg gaccctgaga cttcacaatc ttcagatcaa ggacaagggc    300

ttgtatcaat gtatcatcca tcacaaaaag cccacaggaa tgattcgcat ccaccagatg    360

aattctgaac tgtcagtgct tgctaacttc agtcaacctg aaatagtacc aatttctaat    420

ataacagaaa atgtgtacat aaatttgacc tgctcatcta tacacggtta cccagaacct    480

aagaagatga gtgttttgct aagaaccaag aattcaacta tcgagtatga tggtgttatg    540

cagaaatctc aagataatgt cacagaactg tacgacgttt ccatcagctt gtctgtttca    600

ttccctgatg ttacgagcaa tatgaccatc ttctgtattc tggaaactga caagacgcgg    660

cttttatctt cacctttctc tatagagctt gaggaccctc agcctccccc agaccacatt    720

ccttggatta cagctgtact tgagcctaag tcatgtgaca agacccatac gtgcccaccc    780

tgtcccgctc cagaactgct ggggggacct agcgttttct tgttcccccc aaagcccaag    840

gacaccctca tgatctcacg gactcccgaa gtaacatgcg tagtagtcga cgtgagccac    900

gaggatcctg aagtgaagtt taattggtac gtggacggag tcgaggtgca taatgccaaa    960

actaaacctc gggaggagca gtataacagt acctaccgcg tggtatccgt cttgacagtg   1020

ctccaccagg actggctgaa tggtaaggag tataaatgca aggtcagcaa caaagctctt   1080

cccgccccaa ttgaaaagac tatcagcaag gccaagggac aaccccgcga gccccaggtt   1140

tacacccttc caccttcacg agacgagctg accaagaacc aggtgtctct gacttgtctg   1200

gtcaaaggtt tctatccttc cgacatcgca gtggagtggg agtcaaacgg gcagcctgag   1260

aataactaca agaccacacc cccagtgctt gatagcgatg ggagcttttt cctctacagt   1320

aagctgactg tggacaaatc ccgctggcag cagggaaacg ttttctcttg tagcgtcatg   1380

catgaggccc tccacaacca ttatactcag aaaagcctga gtctgagtcc cggcaaa      1437


<210>  98
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-2 fusion protein with signal peptide

<400>  98

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  99
<211>  456
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-2 fusion protein

<400>  99

Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
1               5                   10                  15      


Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu 
            20                  25                  30          


Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser 
        35                  40                  45              


Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp 
    50                  55                  60                  


Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln 
65                  70                  75                  80  


Cys Ile Ile His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln 
                85                  90                  95      


Met Asn Ser Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile 
            100                 105                 110         


Val Pro Ile Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys 
        115                 120                 125             


Ser Ser Ile His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu 
    130                 135                 140                 


Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser 
145                 150                 155                 160 


Gln Asp Asn Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val 
                165                 170                 175     


Ser Phe Pro Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu 
            180                 185                 190         


Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu 
        195                 200                 205             


Asp Pro Gln Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  100
<211>  1269
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleotide encoding murine B7-H5 fusion protein

<400>  100
atgggtgtcc ccgcggtccc agaggccagc agcccgcgct ggggaaccct gctccttgct     60

attttcctgg ctgcatccag aggtctggta gcagccttca aggtcaccac tccatattct    120

ctctatgtgt gtcccgaggg acagaatgcc accctcacct gcaggattct gggccccgtg    180

tccaaagggc acgatgtgac catctacaag acgtggtacc tcagctcacg aggcgaggtc    240

cagatgtgca aagaacaccg gcccatacgc aacttcacat tgcagcacct tcagcaccac    300

ggaagccacc tgaaagccaa cgccagccat gaccagcccc agaagcatgg gctagagcta    360

gcttctgacc accacggtaa cttctctatc accctgcgca atgtgacccc aagggacagc    420

ggcctctact gctgtctagt gatagaatta aaaaaccacc acccagaaca acggttctac    480

gggtccatgg agctacaggt acaggcaggc aaaggctcgg ggtccacatg catggcgtct    540

aatgagcagg acagtgacag catcacggct gagccaagag gtcctacgat caagccctgc    600

ccgccttgta aatgcccagc tccaaatttg ctgggtggac cgtcagtctt tatcttcccg    660

ccaaagataa aggacgtctt gatgattagt ctgagcccca tcgtgacatg cgttgtggtg    720

gatgtttcag aggatgaccc cgacgtgcaa atcagttggt tcgttaacaa cgtggaggtg    780

cataccgctc aaacccagac ccacagagag gattataaca gcaccctgcg ggtagtgtcc    840

gccctgccga tccagcatca ggattggatg agcgggaaag agttcaagtg taaggtaaac    900

aacaaagatc tgccagcgcc gattgaacga accattagca agccgaaagg gagcgtgcgc    960

gcacctcagg tttacgtcct tcctccacca gaagaggaga tgacgaaaaa gcaggtgacc   1020

ctgacatgca tggtaactga ctttatgcca gaagatattt acgtggaatg gactaataac   1080

ggaaagacag agctcaatta caagaacact gagcctgttc tggattctga tggcagctac   1140

tttatgtact ccaaattgag ggtcgagaag aagaattggg tcgagagaaa cagttatagt   1200

tgctcagtgg tgcatgaggg cctccataat catcacacca caaagtcctt cagccgaacg   1260

cccgggaaa                                                           1269


<210>  101
<211>  423
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-H5 fusion protein with signal peptide

<400>  101

Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
    50                  55                  60                  


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
                85                  90                  95      


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
            100                 105                 110         


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
        115                 120                 125             


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
    130                 135                 140                 


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
145                 150                 155                 160 


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
                165                 170                 175     


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Glu Pro 
            180                 185                 190         


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
        195                 200                 205             


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
    210                 215                 220                 


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
225                 230                 235                 240 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
                245                 250                 255     


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
            260                 265                 270         


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
        275                 280                 285             


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
    290                 295                 300                 


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
305                 310                 315                 320 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
                325                 330                 335     


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
            340                 345                 350         


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
        355                 360                 365             


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
    370                 375                 380                 


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
385                 390                 395                 400 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
                405                 410                 415     


Phe Ser Arg Thr Pro Gly Lys 
            420             


<210>  102
<211>  391
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic murine B7-H5 fusion protein

<400>  102

Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
            20                  25                  30          


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
    50                  55                  60                  


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
65                  70                  75                  80  


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
                85                  90                  95      


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
            100                 105                 110         


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
        115                 120                 125             


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
    130                 135                 140                 


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Glu Pro 
145                 150                 155                 160 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                165                 170                 175     


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            180                 185                 190         


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
        195                 200                 205             


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    210                 215                 220                 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
225                 230                 235                 240 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                245                 250                 255     


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
            260                 265                 270         


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
        275                 280                 285             


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
    290                 295                 300                 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
                325                 330                 335     


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            340                 345                 350         


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
        355                 360                 365             


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
    370                 375                 380                 


Phe Ser Arg Thr Pro Gly Lys 
385                 390     


<210>  103
<211>  1275
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleotide encoding  human B7-H5 fusion protein

<400>  103
atgggcgtcc ccacggccct ggaggccggc agctggcgct ggggatccct gctcttcgct     60

ctcttcctgg ctgcgtccct aggtccggtg gcagccttca aggtcgccac gccgtattcc    120

ctgtatgtct gtcccgaggg gcagaacgtc accctcacct gcaggctctt gggccctgtg    180

gacaaagggc acgatgtgac cttctacaag acgtggtacc gcagctcgag gggcgaggtg    240

cagacctgct cagagcgccg gcccatccgc aacctcacgt tccaggacct tcacctgcac    300

catggaggcc accaggctgc caacaccagc cacgacctgg ctcagcgcca cgggctggag    360

tcggcctccg accaccatgg caacttctcc atcaccatgc gcaacctgac cctgctggat    420

agcggcctct actgctgcct ggtggtggag atcaggcacc accactcgga gcacagggtc    480

catggtgcca tggagctgca ggtgcagaca ggcaaagatg caccatccaa ctgtgtggtg    540

tacccatcct cctcccagga tagtgaaaac atcacggctg agcctaagtc atgtgacaag    600

acccatacgt gcccaccctg tcccgctcca gaactgctgg ggggacctag cgttttcttg    660

ttccccccaa agcccaagga caccctcatg atctcacgga ctcccgaagt aacatgcgta    720

gtagtcgacg tgagccacga ggatcctgaa gtgaagttta attggtacgt ggacggagtc    780

gaggtgcata atgccaaaac taaacctcgg gaggagcagt ataacagtac ctaccgcgtg    840

gtatccgtct tgacagtgct ccaccaggac tggctgaatg gtaaggagta taaatgcaag    900

gtcagcaaca aagctcttcc cgccccaatt gaaaagacta tcagcaaggc caagggacaa    960

ccccgcgagc cccaggttta cacccttcca ccttcacgag acgagctgac caagaaccag   1020

gtgtctctga cttgtctggt caaaggtttc tatccttccg acatcgcagt ggagtgggag   1080

tcaaacgggc agcctgagaa taactacaag accacacccc cagtgcttga tagcgatggg   1140

agctttttcc tctacagtaa gctgactgtg gacaaatccc gctggcagca gggaaacgtt   1200

ttctcttgta gcgtcatgca tgaggccctc cacaaccatt atactcagaa aagcctgagt   1260

ctgagtcccg gcaaa                                                    1275


<210>  104
<211>  425
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-H5 fusion protein with signal peptide

<400>  104

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425 


<210>  105
<211>  393
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic human B7-H5 fusion protein

<400>  105

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
    130                 135                 140                 


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
145                 150                 155                 160 


Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                165                 170                 175     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            180                 185                 190         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        195                 200                 205             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    210                 215                 220                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
225                 230                 235                 240 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                245                 250                 255     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            260                 265                 270         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        275                 280                 285             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    290                 295                 300                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
305                 310                 315                 320 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                325                 330                 335     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            340                 345                 350         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        355                 360                 365             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    370                 375                 380                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390             


