                         SEQUENCE LISTING

<110>  Biofocus DPI B.V.
       Fischer, David Frederik
       Tessari, Michela
       Rooseboom, Marjet
       Scaffidi, Amelia Katie
       Janssen, Richard Antonius Jozef
 
<120>  METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR INCREASING THE 
       FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED 
       MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

<130>  GAL-141-WO-PCT

<150>  US 61/191,809
<151>  2008-09-11

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  2824
<212>  DNA
<213>  Homo sapiens

<400>  1
daacgaacag aagggcgaga gaattggcag gatccgtctc ctacctcttc ctaggcccac       60

agccagtgcc tttggagtac tgaggcgcgc acagagtcct tagcccggcg cagggcgcgc      120

agcccaggct gagatccgct gcttctgtgg aagtgagcat ggttgggcag cgggtgctgc      180

ttctagtggc cttccttctt tctggggtcc tgctctcaga ggctgccaaa atcctgacaa      240

tatctacact gggtggaagc cattacctac tgttggaccg ggtgtctcag attcttcaag      300

agcatggtca taatgtgact atgcttcatc agagtggaaa gtttttgatc ccagatatta      360

aagaggagga aaaatcatac caagttatca ggtggttttc acctgaagat catcaaaaaa      420

gaattaagaa gcattttgat agctacatag aaacagcatt ggatggcaga aaagaatctg      480

aagcccttgt aaagctaatg gaaatatttg ggactcaatg tagttatttg ctaagcagaa      540

aggatataat ggattcctta aagaatgaga actgtgatct ggtatttgtt gaagcatttg      600

atttctgttc tttcctgatt gctgagaagc ttgtgaaacc atttgtggcc attcttccca      660

ccacattcgg ctctttggat tttgggctac caagcccctt gtcttatgtt ccagtattcc      720

cttccttgct gactgatcac atggacttct ggggccgagt gaagaatttt ctgatgttct      780

ttagtttctc caggagccaa tgggacatgc agtctacatt tgacaacacc atcaaggagc      840

atttcccaga aggctctagg ccagttttgt ctcatcttct actgaaagca gagttgtggt      900

ttgttaactc tgattttgcc tttgattttg cccggcccct gcttcccaac actgtttata      960

ttggaggctt gatggaaaaa cctattaaac cagtaccaca agacttggac aacttcattg     1020

ccaactttgg ggatgcaggg tttgtccttg tggcctttgg ctccatgttg aacacccatc     1080

agtcccagga agtcctcaag aagatgcaca atgcctttgc ccacctccct caaggagtga     1140

tatggacatg tcagagttct cattggccca gagatgttca tttggccaca aatgtgaaaa     1200

ttgtggactg gcttcctcag agtgacctcc tggctcaccc cagcatccgt ctttttgtca     1260

ctcatggtgg gcagaacagc gtaatggaga ccatccgtca tggtgtgccc atggtgggat     1320

taccagtcaa tggagaccag catggaaaca tggtccgagt agtagccaaa aattatggtg     1380

tctctatccg gttgaatcag gtcacagccg acacactgac acttacaatg aaacaagtca     1440

tagaagacaa gaggtacaag tcggcagtgg tggcagccag tgtcatcctg cactctcagc     1500

ccctgagccc cgcacagcgg ctggtgggct ggatcgacca catcctccag actgggggag     1560

cgacgcacct caagccctat gtcttccagc agccttggca tgagcagtac ctcattgatg     1620

tctttgtgtt tctgctgggg ctcactctgg gcactatgtg gctttgtggg aagctgctgg     1680

gtgtggtggc caggtggctg cgtggggcca ggaaggtgaa gaagacatga ggctaggtgt     1740

agccttgggt gaggggaggg catccctggt cctttgaagg ttctccccac cccagcacac     1800

gccacccctc tgttctctct tcagctccac ccgccactga tcctgcaact tgcttctttc     1860

tattctctgc ctctgtttag aaatcttcac acaccactga ggcttcttga cttgcccctt     1920

gtgacttgaa accccagctc agatacaaat tttcacctgc cagccctgcc tcctcctttc     1980

tcccttttcc tagacacagg actctgacaa cttcatcctc cttgtttaga tgacttccca     2040

gtttccagtc cccatttctc cttctatcac ttttcataaa aaaactcagg aaatatttga     2100

catatcttcc atttcaaatt cttccatttt atgcagatat cttgcccttc ctataagctc     2160

tcctcaaagc tcaggaaacc tggtctgctc tcctgcattt agggaaggag aacccctgcc     2220

aagacctttg ctcactgcct gagacccctt ccttagagag cacctccttt gctggtcaga     2280

catggagcct gcagttggtc acagatgata ctgctttatt tcagttttta cagttgcctt     2340

cttaagattc ccgtcttata aatggagtac agggaacctc aagtagtgaa gtggaaatcc     2400

atgtgtaagg ctttgtggct tcaggtacca gtggctaagg tagttttaaa gactttgttg     2460

attttagaaa aagtccatct tccatcccct acatggcagt taataccctt ctatatggta     2520

aaaccttaga gattacctta atctgctagg aacagaagca agaaaaacca tggcgtaaac     2580

acccccagag tttttgttca tttgtttcat ctttcttgat aaagcccgaa ggtagcccat     2640

tcagggctgt tgtggttggt tgctccatca tgtcatcaat agcccatatc ttttcttttt     2700

tatcttcctt agtataacac caaactacct ctctgatagc tggtgttcat gaaatatttt     2760

accttcaaat gattgtacct ttttatttgc tttagagttc tgaaataaaa tgaaattcca     2820

ctgt                                                                  2824


<210>  2
<211>  2341
<212>  DNA
<213>  Homo sapiens

<400>  2
agtgcctttg gcgcactgag gtgcacaggg tcccttagcc gggcgcaggg cgcgcagccc       60

aggctgagat ccgcggcttc cgtagaagtg agcatggctg ggcagcgagt gcttcttcta      120

gtgggcttcc ttctccctgg ggtcctgctc tcagaggctg ccaaaatcct gacaatatct      180

acagtaggtg gaagccatta tctactgatg gaccgggttt ctcagattct tcaagatcac      240

ggtcataatg tcaccatgct taaccacaaa agaggtcctt ttatgccaga ttttaaaaag      300

gaagaaaaat catatcaagt tatcagttgg cttgcacctg aagatcatca aagagaattt      360

aaaaagagtt ttgatttctt tctggaagaa actttaggtg gcagaggaaa atttgaaaac      420

ttattaaatg ttctagaata cttggcgttg cagtgcagtc attttttaaa tagaaaggat      480

atcatggatt ccttaaagaa tgagaacttc gacatggtga tagttgaaac ttttgactac      540

tgtcctttcc tgattgctga gaagcttggg aagccatttg tggccattct ttccacttca      600

ttcggctctt tggaatttgg gctaccaatc cccttgtctt atgttccagt attccgttcc      660

ttgctgactg atcacatgga cttctggggc cgagtgaaga attttctgat gttctttagt      720

ttctgcagga ggcaacagca catgcagtct acatttgaca acaccatcaa ggaacatttc      780

acagaaggct ctaggccagt tttgtctcat cttctactga aagcagagtt gtggttcatt      840

aactctgact ttgcctttga ttttgctcga cctctgcttc ccaacactgt ttatgttgga      900

ggcttgatgg aaaaacctat taaaccagta ccacaagact tggagaactt cattgccaag      960

tttgaggact ctggttttgt ccttgtgacc ttgggctcca tggtgaacac ctgtcagaat     1020

ccggaaatct tcaaggagat gaacaatgcc tttgctcacc taccccaagg ggtgatatgg     1080

aagtgtcagt gttctcattg gcccaaagat gtccacctgg ctgcaaatgt gaaaattgtg     1140

gactggcttc ctcagagtga cctcctggct cacccaagca tccgtctgtt tgtcacccac     1200

ggcgggcaga atagcataat ggaggccatc cagcatggtg tgcccatggt ggggatccct     1260

ctctttggag accagcctga aaacatggtc cgagtagaag ccaaaaagtt tggtgtttct     1320

attcagttaa agaagctcaa ggcagagaca ttggctctta agatgaaaca aatcatggaa     1380

gacaagagat acaagtccgc ggcagtggct gccagtgtca tcctgcgctc ccacccgctc     1440

agccccacac agcggctggt gggctggatt gaccacgtcc tccagacagg gggcgcgacg     1500

cacctcaagc cctatgtctt tcagcagccc tggcatgagc agtacctgct cgacgttttt     1560

gtgtttctgc tggggctcac tctggggact ctatggcttt gtgggaagct gctgggcatg     1620

gctgtctggt ggctgcgtgg ggccagaaag gtgaaggaga cataaggcca ggtgcagcct     1680

tggcggggtc tgtttggtgg gcgatgtcac catttctagg gagcttccca ctagttctgg     1740

cagccccatt ctctagtcct tctagttatc tcctgttttc ttgaagaaca ggaaaaatgg     1800

ccaaaaatca tcctttccac ttgctaattt tgctacaaat tcatccttac tagctcctgc     1860

ctgctagcag aattctttcc agtcctcttg tcctcctttg tttgccatca gcaagggcta     1920

tgctgtgatt ctgtctctga gtgacttgga ccactgaccc tcagatttcc agccttaaaa     1980

tccaccttcc ttctcatgcg cctctccgaa tcacaccctg actcttccag cctccatgtc     2040

cagacctagt cagcctctct cactcctgcc cctactatct atcatggaat aacatccaag     2100

aaagacacct tgcatattct ttcagtttct gttttgttct cccacatatt ctcttcaatg     2160

ctcaggaagc ctgccctgtg cttgagagtt cagggccgga cacaggctca caggtctcca     2220

cattgggtcc ctgtctctgg tgcccacagt gagctccttc ttggctgagc aggcatggag     2280

actgtaggtt tccagatttc ctgaaaaata aaagtttaca gcgttatctc tccccaacct     2340

c                                                                     2341


<210>  3
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  3
gaggaggagg aggagatgac tggggagcgg gagctcgaga atactgccca gttactctag       60

cgcgccaggc cgaaccgcag cttcttggct taggtacttc tactcacagc ggccgattcc      120

gaggccaact ccagcaatgg cttttgcaaa tctgcggaaa gtgctcatca gtgacagcct      180

ggacccttgc tgccggaaga tcttgcaaga tggagggctg caggtggtgg aaaagcagaa      240

ccttagcaaa gaggagctga tagcggagct gcaggactgt gaaggcctta ttgttcgctc      300

tgccaccaag gtgaccgctg atgtcatcaa cgcagctgag aaactccagg tggtgggcag      360

ggctggcaca ggtgtggaca atgtggatct ggaggccgca acaaggaagg gcatcttggt      420

tatgaacacc cccaatggga acagcctcag tgccgcagaa ctcacttgtg gaatgatcat      480

gtgcctggcc aggcagattc cccaggcgac ggcttcgatg aaggacggca aatgggagcg      540

gaagaagttc atgggaacag agctgaatgg aaagaccctg ggaattcttg gcctgggcag      600

gattgggaga gaggtagcta cccggatgca gtcctttggg atgaagacta tagggtatga      660

ccccatcatt tccccagagg tctcggcctc ctttggtgtt cagcagctgc ccctggagga      720

gatctggcct ctctgtgatt tcatcactgt gcacactcct ctcctgccct ccacgacagg      780

cttgctgaat gacaacacct ttgcccagtg caagaagggg gtgcgtgtgg tgaactgtgc      840

ccgtggaggg atcgtggacg aaggcgccct gctccgggcc ctgcagtctg gccagtgtgc      900

cggggctgca ctggacgtgt ttacggaaga gccgccacgg gaccgggcct tggtggacca      960

tgagaatgtc atcagctgtc cccacctggg tgccagcacc aaggaggctc agagccgctg     1020

tggggaggaa attgctgttc agttcgtgga catggtgaag gggaaatctc tcacgggggt     1080

tgtgaatgcc caggccctta ccagtgcctt ctctccacac accaagcctt ggattggtct     1140

ggcagaagct ctggggacac tgatgcgagc ctgggctggg tcccccaaag ggaccatcca     1200

ggtgataaca cagggaacat ccctgaagaa tgctgggaac tgcctaagcc ccgcagtcat     1260

tgtcggcctc ctgaaagagg cttccaagca ggcggatgtg aacttggtga acgctaagct     1320

gctggtgaaa gaggctggcc tcaatgtcac cacctcccac agccctgctg caccagggga     1380

gcaaggcttc ggggaatgcc tcctggccgt ggccctggca ggcgcccctt accaggctgt     1440

gggcttggtc caaggcacta cacctgtact gcaggggctc aatggagctg tcttcaggcc     1500

agaagtgcct ctccgcaggg acctgcccct gctcctattc cggactcaga cctctgaccc     1560

tgcaatgctg cctaccatga ttggcctcct ggcagaggca ggcgtgcggc tgctgtccta     1620

ccagacttca ctggtgtcag atggggagac ctggcacgtc atgggcatct cctccttgct     1680

gcccagcctg gaagcgtgga agcagcatgt gactgaagcc ttccagttcc acttctaacc     1740

ttggagctca ctggtccctg cctctggggc ttttctgaag aaacccaccc actgtgatca     1800

atagggagag aaaatccaca ttcttgggct gaacgcgggc ctctgacact gcttacactg     1860

cactctgacc ctgtagtaca gcaataaccg tctaataaag agcctacccc caaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1968


<210>  4
<211>  2720
<212>  DNA
<213>  Homo sapiens

<400>  4
agaggggcgg gagctctggc tcaggtaaaa actctttctt cggctcgcga gctgagagga       60

gcaggtagag gggcagaggc gggactgtcg tctgggggag ccgcccagga ggctcctcag      120

gccgacccca gaccctggct ggccaggatg aagtatctcc ggcaccggcg gcccaatgcc      180

accctcattc tggccatcgg cgctttcacc ctcctcctct tcagtctgct agtgtcacca      240

cccacctgca aggtccagga gcagccaccg gcgatccccg aggccctggc ctggcccact      300

ccacccaccc gcccagcccc ggccccgtgc catgccaaca cctctatggt cacccacccg      360

gacttcgcca cgcagccgca gcacgttcag aacttcctcc tgtacagaca ctgccgccac      420

tttcccctgc tgcaggacgt gcccccctct aagtgcgcgc agccggtctt cctgctgctg      480

gtgatcaagt cctcccctag caactatgtg cgccgcgagc tgctgcggcg cacgtggggc      540

cgcgagcgca aggtacgggg tttgcagctg cgcctcctct tcctggtggg cacagcctcc      600

aacccgcacg aggcccgcaa ggtcaaccgg ctgctggagc tggaggcaca gactcacgga      660

gacatcctgc agtgggactt ccacgactcc ttcttcaacc tcacgctcaa gcaggtcctg      720

ttcttacagt ggcaggagac aaggtgcgcc aacgccagct tcgtgctcaa cggggatgat      780

gacgtctttg cacacacaga caacatggtc ttctacctgc aggaccatga ccctggccgc      840

cacctcttcg tggggcaact gatccaaaac gtgggcccca tccgggcttt ttggagcaag      900

tactatgtgc cagaggtggt gactcagaat gagcggtacc caccctattg tgggggtggt      960

ggcttcttgc tgtcccgctt cacggccgct gccctgcgcc gtgctgccca tgtcttggac     1020

atcttcccca ttgatgatgt cttcctgggt atgtgtctgg agcttgaggg actgaagcct     1080

gcctcccaca gcggcatccg cacgtctggc gtgcgggctc catcgcaacg cctgtcctcc     1140

tttgacccct gcttctaccg agacctgctg ctggtgcacc gcttcctacc ttatgagatg     1200

ctgctcatgt gggatgcgct gaaccagccc aacctcacct gcggcaatca gacacagatc     1260

tactgagtca gcatcagggt ccccagcctc tgggctcctg tttccatagg aaggggcgac     1320

accttcctcc caggaagctg agacctttgt ggtctgagca taagggagtg ccagggaagg     1380

tttgaggttt gatgagtgaa tattctggct ggcgaactcc tacacatcct tcaaaaccca     1440

cctggtactg ttccagcatc ttccctggat ggctggagga actccagaaa atatccatct     1500

tctttttgtg gctgctaatg gcagaagtgc ctgtgctaga gttccaactg tggatgcatc     1560

cgtcccgttt gagtcaaagt cttacttccc tgctctcacc tactcacaga cgggatgcta     1620

agcagtgcac ctgcagtggt ttaatggcag ataagctccg tctgcagttc caggccagcc     1680

agaaactcct gtgtccacat agagctgacg tgagaaatat ctttcagccc aggagagagg     1740

ggtcctgatc ttaacccttt cctgggtctc agacaactca gaaggttggg gggataccag     1800

agaggtggtg gaataggacc gccccctcct tacttgtggg atcaaatgct gtaatggtgg     1860

aggtgtgggc agaggaggga ggcaagtgtc ctttgaaagt tgtgagagct cagagtttct     1920

ggggtcctca ttaggagccc ccatccctgt gttccccaag aattcagaga acagcactgg     1980

ggctggaatg atctttaatg ggcccaaggc caacaggcat atgcctcact actgcctgga     2040

gaagggagag attcaggtcc tccagcagcc tccctcaccc agtatgtttt acagattacg     2100

gggggaccgg gtgagccagt gaccccctgt agcccccagc ttcaggcctc agtgtctgcc     2160

agtcaagctt cacaggcatt gtgatggggc agccttgggg aatataaaat tttgtgaaga     2220

cttggagatc tttttttttt tttaagcaaa tttacaagtt tcaacagaca agtccacatt     2280

catccctaaa agtctcattt tccagtagaa aatatacact ggtaaaaacg gggcatgggg     2340

ccgtggctca gggctgtaat tctagcacat tgggagacca aagtgggagg atcacttgag     2400

cccaggagtt ctggatcctg tctctgcaca aaataaaaaa ttactcaggc gtggtggtgc     2460

tcacatgcct gtagtcccag ctatacttgg gaggctgagg cgagaggatc gcttgagccc     2520

aggagttgga ggctgcagtg aaccatgatt gcgccactgt actccactgg gcggcaataa     2580

gaagacaaaa acataaaaca ggacatgtgt gaggcaaaag ctgcaggaat ttctatcagg     2640

cagatctgac ctcatcccac ccaccccctg ctcagatacc cttcatagct ccttattgct     2700

ttcagctcat aaccccacat                                                 2720


<210>  5
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  5
gaaatccgcg gaccgggctt taggttcgcc ggaatcccac gctcccgact tctgcttccg       60

ggtcggagcc atggcggtgg caaattcaag tcctgttaac cccgtggtgt tctttgatgt      120

cagtattggc ggtcaggaag ttggccgcat gaagatcgag ctctttgcag acgttgtgcc      180

taagacggcc gagaacttta ggcagttctg caccggagaa ttcaggaaag atggggttcc      240

aataggatac aaaggaagca ccttccacag ggtcataaag gatttcatga ttcagggtgg      300

agattttgtt aatggagatg gtactggagt cgccagtatt taccgggggc catttgcaga      360

tgaaaatttt aaacttagac actcagctcc aggcctgctt tccatggcga acagtggtcc      420

aagtacaaat ggctgtcagt tctttatcac ctgctctaag tgcgattggc tggatgggaa      480

gcatgtggtg tttggaaaaa tcatcgatgg acttctagtg atgagaaaga ttgagaatgt      540

tcccacaggc cccaacaata agcccaagct acctgtggtg atctcgcagt gtggggagat      600

gtagtccaga caaagactga atcaggcctt cccttcttct tggtggtgtt cttgagtaag      660

ataatctgga ctggcccccg tctttgcttc cctgcctgct gctgccccat ttgatcaaga      720

gaccatggaa gtgtcagaga ttcagaatcc aagattgtct ttaagttttc aactgtaaat      780

aaagtttttt tgtatgcgta aaaaaaaaaa aaa                                   813


<210>  6
<211>  11974
<212>  DNA
<213>  homo sapiens

<400>  6
agcgaaccat cggggcggcc gggagccatg ttggagcggc gggaggcggc agcagcgtcg       60

gggatgctgt ggtgggggcg gaaaaagcca gggccgcacg ccggaggggc tccggccgcg      120

gagtagatgg tgcccagagg gcggcggggg tgcggagaga caggcggagg ggcgggggcc      180

cggggcggcg gcaggggccc gggagggggc ccgagcggcg gggccagccc aaggcccgga      240

ccggggcggg gggcggtgga ggccgtgcag ggaggcgggg gatgatggcg aggcggccgc      300

cgtggcgggg cctcggggga cggtcgaccc ccatactcct gctccttctc ctctctttgt      360

tccccctcag ccaggaggag ctggggggcg gtgggcacca gggctgggac ccaggcttag      420

ctgccactac ggggccaagg gcgcatatcg gtggcggagc cttagctctt tgtccggagt      480

cttccggggt ccgggaggat ggggggcctg gcctgggggt cagggagcct atcttcgtgg      540

ggctccgagg gagaaggcaa agcgcccgga atagtcgagg gccccctgag cagccgaatg      600

aggagctggg gattgaacac ggcgtccagc cattgggcag ccgcgaacga gagacaggac      660

agggaccagg gtctgtgtta tactggcgcc cagaggtctc ctcttgcggg cggacaggac      720

ctttgcaaag aggtagtctg tcaccagggg ctctgtcctc aggggtcccg ggctcgggga      780

acagctcgcc cctcccttca gactttttga ttcggcacca cggtcccaag ccggtgtcct      840

cccagcggaa cgctgggaca ggctcccgca aaagagtggg caccgcgcgc tgctgtgggg      900

aattatgggc aacagggagc aagggtcagg gcgagagagc cacgacatcc ggagcagaaa      960

ggacagcccc ccggcggaac tgtcttccag gggcctcggg atctggcccc gagctggatt     1020

cagcaccacg cacggcgagg acagctcctg catcaggttc agcaccccgc gagtctcgga     1080

cagctcccga gccggcgccc aagcgcatgc gctcccgggg tctcttccgc tgccgcttcc     1140

tcccgcagcg ccccgggccg cgtcccccgg gactcccggc ccgtcctgaa gccaggaaag     1200

taacctcggc gaaccgggca cgctttcgtc gcgccgcaaa ccgccacccg cagtttccgc     1260

agtacaacta ccagacgctg gtgccggaga atgaggcagc aggcaccgcg gtgctacgcg     1320

tggttgctca ggacccggac gccggcgagg ccgggcgcct agtctactcg ctggcggcac     1380

tcatgaacag ccgctcgctg gagctgttca gcatcgaccc gcagagcggc cttatccgta     1440

cggcggcagc tctggaccgc gagagcatgg agcgtcacta cctgcgtgtg accgcgcagg     1500

accacgggtc gccgcgcctc tcggccacca cgatggtggc cgtgacagta gccgaccgca     1560

acgaccactc gccggttttt gagcaagcgc agtaccggga gacccttcgc gagaatgtgg     1620

aggagggcta ccctatcctg cagctgcgtg ccactgacgg cgacgcgccc cccaacgcca     1680

acctgcgcta ccgcttcgtg gggccgccag ctgcgcgcgc tgcagctgcc gccgccttcg     1740

agattgatcc acgctccggc ctcatcagca ccagcggccg agtggaccgc gagcacatgg     1800

aaagctatga gctggtggtg gaagccagcg accagggcca ggaacccggg ccgcgctcgg     1860

ccactgtgcg cgtacacata actgtgctag acgagaacga caatgctcct cagttcagcg     1920

agaagcgcta cgtggcgcag gtgcgcgagg atgtgcgccc ccacacagtc gtgctgcgcg     1980

tcacggccac tgaccgggac aaggacgcca acggattggt gcactacaac atcatcagtg     2040

gcaatagccg tggacacttt gccatcgaca gcctcactgg cgagatccag gtggtggcac     2100

ctctggactt cgaggcagag agagagtatg ccttgcgcat cagggcgcag gatgctggcc     2160

ggccaccgct gtccaacaac acgggcctgg ccagcatcca ggtggtggac atcaatgacc     2220

acattcctat ttttgtcagc acgcccttcc aagtttctgt cttggaaaat gctcccttgg     2280

gtcactcagt catccacatt caggcagtcg atgcagacca tggggagaat gccagattgg     2340

agtactccct aactggtgtg gcacctgata ctccttttgt gataaacagc gccactggct     2400

gggtctctgt gagtggtccc ctggaccgtg agtctgtgga gcattacttc tttggtgtgg     2460

aggctcgaga ccatggctca cccccactct ctgcctcagc cagtgtcacc gtgactgtgc     2520

tggacgttaa tgacaatcgg cctgagttca caatgaagga gtaccaccta cgactgaatg     2580

aggatgcagc tgtgggcacc agtgtggtca gcgtgaccgc agtagaccgt gatgccaaca     2640

gtgccatcag ctaccagatc acaggcggca acacccggaa tcgctttgcc atcagcaccc     2700

aggggggtgt gggtctggtg actctggctc tgccactgga ctacaagcag gaacgctact     2760

tcaagctggt actaactgca tctgaccgtg cccttcatga tcactgctat gtgcacatca     2820

acatcacaga tgccaacact catcggccgg tctttcaaag tgcccactac tcagtgagtg     2880

tgaatgaaga tcggccaatg ggtagcacca tagtggtcat cagtgcctct gatgatgacg     2940

tgggtgagaa tgctcgtatc acctatctcc tggaggacaa cctgccccag ttccgcattg     3000

atgcagactc aggagccatt acattacagg ccccattaga ctatgaggac caggtgacct     3060

acaccctggc tatcacagct cgggacaatg gcatcccaca gaaggcagac actacttatg     3120

tggaggtgat ggtcaatgac gtgaatgaca atgctccaca atttgtggcc tcccactata     3180

cagggctggt ctctgaggat gccccacctt tcaccagtgt cctgcagatc tcagccactg     3240

accgggatgc tcatgccaat ggccgggtcc agtacacttt ccagaatggt gaagatgggg     3300

atggagattt taccattgag cccacctctg gaattgtccg tacagtaagg cggctagacc     3360

gggaggcagt atcagtgtat gagttgactg cctacgcagt ggacagaggt gtgcccccac     3420

tccggactcc agtcagtatc caggtgatgg tgcaggatgt gaacgacaat gcacctgtct     3480

tcccagctga ggagtttgag gtgcgggtga aagagaatag cattgtgggc tcagtggtgg     3540

cccagatcac tgcagtggac cctgacgaag gccccaatgc ccatataatg taccagatcg     3600

tggaggggaa catccctgag ctgttccaaa tggacatctt ctctggagaa ctgacggcac     3660

tcattgacct agactatgag gctcgccaag aatatgtgat tgtggtgcag gccacatctg     3720

ctcctttggt cagccgggcc actgtgcacg tccgcctggt tgaccagaat gacaacagcc     3780

ctgtgctcaa caacttccag atcctcttca acaactatgt atccaaccgt tcagacacct     3840

tcccgtcggg cattattggg cgcatcccag cttatgaccc cgatgtctcc gaccacctct     3900

tctactcctt tgagcgtggc aatgagctgc agctgctggt agtcaaccag accagtgggg     3960

agctgcgact cagccgaaag ctagacaata accgcccact ggtggcctcc atgttggtga     4020

ctgtcacaga tggcctgcac agcgtgacgg cgcagtgtgt gctgcgcgtg gtcatcatca     4080

cggaggagtt gctggccaac agcctgaccg tgcgccttga gaacatgtgg caggagcgct     4140

tcctgtcacc gctgctgggc cgcttcctcg agggcgtggc tgcggtgctc gctacgcccg     4200

ctgaggacgt cttcatcttc aacatccaga acgacacaga cgtagggggc accgtgctca     4260

atgtgagttt ctcggcgcta gctccacgtg gggccggggc gggcgctgca gggccctggt     4320

tcagctccga ggagctgcag gagcagttgt acgtgcgccg ggcggcgctg gcggctcgct     4380

ccctgctcga cgtactgccc ttcgacgaca acgtgtgcct gcgagagccc tgtgagaact     4440

acatgaaatg cgtgtccgtg ctccgctttg actcgtccgc gcccttcctg gcctcggcct     4500

ccacgctgtt ccgacccatc cagcccatcg ctggcctgcg ctgccgctgc ccgcccggat     4560

tcacgggaga cttttgcgag accgagctcg acctctgcta ctccaaccca tgtcgcaacg     4620

gcggagcctg cgcgcggcgc gagggaggct acacgtgcgt ctgccgcccg cgcttcaccg     4680

gagaggactg cgagctggac accgaggccg gccgctgcgt gccgggcgtc tgccgcaacg     4740

ggggcacctg caccgacgcg cccaacggcg gctttcgctg ccagtgcccg gcaggcggcg     4800

ccttcgaggg cccgcgctgc gaggtggctg cgcgctcctt cccgcccagt tcgttcgtca     4860

tgtttcgcgg cctgcggcag cgattccacc ttacgctgtc cctctcgttc gcgacagtgc     4920

agcagagcgg gctgctcttc tacaacgggc gcctgaacga gaagcacgac ttcctggccc     4980

tggaactcgt ggctggccaa gtgcggctca catattccac gggtgaatcc aacaccgtgg     5040

tcagccccac agttccaggg ggcttgagtg acgggcaatg gcatacagtg catctgagat     5100

actacaacaa gccccggaca gatgccctag ggggtgcaca gggcccctcc aaggacaagg     5160

tggctgtgct aagcgtggat gattgtgatg tggccgtggc tctgcagttt ggtgctgaga     5220

ttggcaacta ctcatgcgcg gctgctggtg tgcaaacaag ctccaagaag tccctggacc     5280

tgacgggccc tcttcttctg ggaggtgtcc ccaacctccc cgagaacttc cccgtatccc     5340

ataaggactt catcggctgt atgcgggacc tgcacattga tggccgccga gtggacatgg     5400

cggcttttgt cgcaaataat ggcaccatgg caggctgcca agccaagcta cacttttgtg     5460

actcaggccc ctgcaagaac agtggcttct gctcggagcg ctggggcagc ttcagctgcg     5520

actgccctgt gggcttcggc ggcaaagact gtcagcttac tatggcccat ccccaccatt     5580

tccgtggcaa cggcacactg agctggaact ttggaagtga catggctgtg tctgtgccat     5640

ggtacctggg gctggcattt cggacacggg caacgcaggg ggtcctgatg caagtgcagg     5700

ctgggccaca cagcacgctc ctttgccagc tagatcgggg gttactgtct gtgacagtga     5760

ccaggggctc gggccgtgct tcccatctcc ttctggacca ggtgactgtc agtgatggcc     5820

ggtggcacga tctgcggctg gagttgcagg aggaaccagg tggccggcgg ggccaccatg     5880

tccttatggt ctcactggac tttagcctct tccaggacac catggcggtg gggagtgagc     5940

tgcagggcct gaaggtaaag cagctccacg tgggaggcct gccccccggc agtgcagagg     6000

aggctcctca gggtctggtt ggctgcatcc agggggtgtg gctcggctcc acaccctctg     6060

gctccccggc cctgctaccc cccagccacc gagtgaatgc ggagcctggc tgtgttgtga     6120

ccaacgcctg tgcctctggg ccctgcccac ctcacgcaga ctgccgggac ctctggcaga     6180

ccttttcttg cacctgccag ccaggttact acggcccagg ctgtgtggat gcctgcctcc     6240

tgaacccctg tcagaaccag ggatcatgcc ggcacctgcc aggagccccc catggctata     6300

cctgtgactg tgtgggtggc tatttcgggc accactgtga gcacaggatg gaccagcagt     6360

gcccacgggg ctggtggggg agcccaacct gtggcccctg caactgtgat gttcacaaag     6420

gttttgatcc caactgcaac aagacaaatg ggcagtgtca ctgcaaggag ttccactacc     6480

gaccgcgggg cagtgactct tgcctcccat gtgactgcta ccctgtgggc tccacctcgc     6540

gctcatgtgc accccacagc gggcagtgcc cctgtcgccc aggagccctt ggccgccagt     6600

gcaacagctg tgacagtccc ttcgcagagg tgacagccag cggctgccgg gtgctctatg     6660

atgcctgccc taagtccctg agatctggtg tgtggtggcc ccagacaaag tttggcgtcc     6720

tggccacagt gccctgtccc cggggggccc tgggtgctgc tgtgcggctg tgtgatgagg     6780

cccagggttg gctggagccc gacctcttca actgtacctc ccctgccttt cgagagctca     6840

gtctgctgct ggatggccta gagctgaaca agacggcact ggataccatg gaggccaaga     6900

agctggctca gcggctacgg gaggtgactg gccacactga ccactatttt agccaagatg     6960

ttcgagtcac tgcccgcctg ctggcccacc tgctggcctt cgagagccat cagcagggct     7020

tcgggctgac agccacacag gatgcccact tcaatgagaa tctgctgtgg gccggctctg     7080

cactgcttgc cccagagaca ggggacttgt gggcggcgct ggggcagcgg gcccctgggg     7140

gctccccagg cagcgcggga ctggtgaggc acctggagga gtatgcagcc acactcgcaa     7200

ggaatatgga actcacatac ctgaatccca tggggctggt gacgcctaat atcatgctca     7260

gcattgaccg catggagcac cccagttctc cccggggggc ccgtcgctac cctcgctacc     7320

atagcaacct ctttcgaggc caggatgcct gggatcctca cacccatgtg ctgctgcctt     7380

cccagtcccc acggccatcc ccatctgaag ttctgcccac aagcagcagc atagaaaact     7440

ccaccacctc aagtgtggtc cccccaccag ccccgccaga gccagagcct gggatctcca     7500

ttatcattct cctcgtttac cgcaccttag ggggactgct ccctgcccag ttccaggcag     7560

aacgccgagg tgccaggctt cctcagaacc ccgtcatgaa ctccccggtg gtcagcgtgg     7620

ctgtgttcca cggacgcaac ttcctaaggg gaatcctgga gtcccccatc agcctagagt     7680

ttcgcctgct acagacagcg aatcggagca aggcgatctg tgtgcagtgg gacccacctg     7740

gcctggcgga gcagcatggt gtgtggacag cacgggactg cgagctggtg cacaggaatg     7800

ggtcccacgc acggtgtcgc tgcagccgga cagggacctt tggggtcctc atggatgcct     7860

ctccccgtga gaggctggag ggcgacctgg agctgctggc tgtgttcacc cacgtggtcg     7920

tggctgtgtc tgtggctgcg ctggtgctga ctgcagccat cctgctgagc ctgcgcagcc     7980

tcaagtccaa tgtgcgtggg atccatgcca atgtggcagc cgccctgggg gtggcagagc     8040

tcctcttcct gctggggatt cacaggaccc acaatcagct ggtgtgcact gcagtcgcca     8100

tcctcctgca ctacttcttc ctcagcacct tcgcgtggct cttcgtgcag gggctgcacc     8160

tctaccgcat gcaggttgag ccacgcaacg tggaccgcgg cgccatgcgc ttctaccatg     8220

ccctgggctg gggcgtccct gctgtgctgc tgggccttgc tgtgggcctg gaccctgagg     8280

gctatgggaa ccctgacttc tgctggatct cagtccacga gcccctcatc tggagctttg     8340

ctggccctgt tgtcctggtc atagtgatga acgggaccat gtttctcctc gctgcccgca     8400

catcctgctc cacagggcag agggaggcca agaagacctc tgcactgacc cttcgcagct     8460

ccttcctgct gcttctgctg gtcagtgcct cctggctctt tgggctcctg gcagtcaacc     8520

acagcatcct agccttccac tacctccatg ctggactctg cggcctccag ggcctggcgg     8580

tgctgctgct cttctgtgtc ctaaatgcag atgctcgggc tgcctggatg ccagcctgtc     8640

tgggcaggaa ggcagcgcct gaggaggcaa ggccagcacc tgggctggga cctggggcct     8700

acaacaacac ggctctcttt gaggagagtg gcctcatccg catcactctg ggcgcctcca     8760

ccgtctcctc tgtgagcagt gcccgctccg gccggaccca ggaccaggac agccagcggg     8820

gccgcagcta cctcagggac aatgtcctgg ttcgacatgg ctcagccgct gaccacactg     8880

accacagcct ccaggctcat gctggcccca ctgacctgga cgtggccatg ttccatcgag     8940

atgctggcgc agactccgac tctgacagtg acctgtcctt ggaggaggag aggagtctct     9000

ccattccatc ttcagaaagc gaggacaatg gccggacgcg ggggcgcttc caacggccac     9060

tctgccgagc agcccagagt gagaggctcc tcacccaccc caaagatgtg gatggcaatg     9120

acctcctgtc ctactggcca gccctggggg agtgcgaggc agccccctgt gctctgcaga     9180

cttggggctc tgaaaggcgc ctggggctgg acaccagcaa ggatgcagct aacaacaacc     9240

agccagaccc ggccctgacc agtggggatg agacttctct gggccgggcc cagcgccaga     9300

ggaaaggcat cctgaagaac cggttgcaat acccactggt gccacagacc cgaggtgccc     9360

ctgagctgtc ctggtgccgt gcagccacct tgggccaccg tgctgtgcca gctgcctctt     9420

acggtcgcat ctatgctggc gggggcacgg gcagcctttc acagccagcc agccgctact     9480

cttctagaga acagctggac ctgctcctcc ggcggcaact gagccgtgag cgactagagg     9540

aagcccctgc ccctgttcta cgtcccctga gccggccagg gtcccaggaa tgcatggatg     9600

ctgcaccagg ccgactggag cccaaagatc ggggcagcac cctgccacgg aggcagccac     9660

ctcgggacta ccctggcgcc atggctggcc gcttcgggtc acgggatgcg ctcgacttag     9720

gggcacctcg agagtggttg agcacgctgc ctccgccccg ccgcacccgg gaccttgacc     9780

cacagccccc acctctgccc ctgtctcccc agcggcaact ctcaagggac cccctcttgc     9840

catcccggcc gctggactct ctgtctagga gctcgaactc tcgggagcag ctggaccagg     9900

tgcctagccg gcacccctca cgagaagccc ttgggccact cccgcagctg ctcagagcta     9960

gggaggactc ggtcagtggc cccagccatg gcccctccac agaacagttg gacattcttt    10020

cctccatcct tgcctctttc aactcctcgg ccctctcctc tgtgcaatct tcaagcacac    10080

ccttgggccc tcacaccact gccacacctt ctgccacagc ctctgtgctt gggccctcca    10140

cgccacgttc tgccacgtct cacagcatct cggagctgtc gccagactca gaagttccca    10200

gaagtgaggg tcactcctga ggggatgacg gcgtggacga ggaacagctg agggcgacag    10260

aggatctagg ctaacaggag agactccagg agtgggggca gatcccaagg cagcctcctg    10320

ctccccagtg gtgggtgccc cagctctacc tggtgtggca gggctgaggc tccatgtgca    10380

tctgtgagca tgcgtgtgac aggtgcagag acgggggact ggagggagac ttttatacgt    10440

tttgtacctt tgtaaccaga gagatgctta tgttattttt cagcttttct gtctcctggg    10500

gggtttgagg ctgggctggg agggggaggg agatagaggg agagatgcag tttgacccca    10560

tttgggtcct gagcaaaccc tatgctcatc tctctctcct tcctggggtg gactcagatg    10620

ggtgggacac atgccttcct ccccctattc cacccccaag ttgatctgag tatcgtcagg    10680

ggcccaaagt acagaattgt tctttgcttt ttattgaatg ctccaaaggc caaacttctg    10740

gggctggggg ttggtcttgg aaacaggggt cctctgactt cctcatgggg gcttgctcat    10800

accgcccctc ctggtggatg tgtgtgttta ttatgtggag tccctgccac ttactgcctt    10860

atgacctagg actgatgctg tggggtgctg gtggagcagc tgatgtcgtg tttacagagc    10920

aaggcttccc tgtctcccac ggggaggggc tcgggcctct agtcagacat tcctgcagag    10980

ggtcggtgga ggggtcattc acctgcccct gcagcaagca aaagttgtct gtggtgccat    11040

ttgattccct gacactgccc cctgcttgaa ttgattccga agggtagggt gggaaggtga    11100

gcaaagggag cagaaacaag ggaattcaag acccagaatg taggtgccac tgcctcctat    11160

gtttacagga tcctccgtgg ccctaggcac ctgggctgca ggaagtgact ccgttccact    11220

cctcctttat tcccttaaaa agggaaaaat gactgttacg accctgttca caaaactctt    11280

acttttgcta ttttgtctgc tgtccagaac tgaagacttt aaaattttgt tactgtttac    11340

aagtccagat tcaaaaaatg tttttacttt gtttacaact caaaactttg agttttacac    11400

tttgtttaca gtagataatt ttttttcctt tgtttccaag tgaaaggtag ggaaagtggg    11460

agagggactt ggaggaccca cctgtgagga ccctgacctg gccatcttga ggggttttct    11520

aacccccagg tctcccaggc cgaaggtcag ccttgagtcc cgtttaacag cagatccaga    11580

agaccttgag agtaggcgtc ctctaaccac gggggagagt ggctgtgcag ggctgggggg    11640

tggtctgtgc agacacctcc tcacccacca ccccatgcat actcttggga agcagcttcc    11700

tgggagatta gaaattctac ttccctgact ggagctaaat cccaccagcc aggacccaaa    11760

ctctccttac cgagaaggac cccagctctt gaagggctga gtggcctgct gggggtggga    11820

gggtgtcttt actatgtcct aggtttcgta gatgcccctc tctggggttc ccctcctcca    11880

gcccagcggc cctctttcct gtctgtgtaa attgttccgt gaagccgcgc tctgttttgg    11940

gaataaactt ctatagaaaa caaaaaaaaa aaaa                                11974


<210>  7
<211>  3652
<212>  DNA
<213>  homo sapiens

<400>  7
attccttctc attcattttg cccagaaagt tcctgcttca gagctgaagg tgattgggag       60

attttaactt agatctccag caagtgctac aaggaagaaa agatcctgaa gaatcaatca      120

agttttccgt gaagtcaagt ccaagtaaca tccccgcctt aaccacaagc aggagaaatg      180

aagcacatta tcaactcgta tgaaaacatc aacaacacag caagaaataa ttccgactgt      240

cctcgtgtgg ttttgccgga ggagatattt ttcacaattt ccattgttgg agttttggag      300

aatctgatcg tcctgctggc tgtgttcaag aataagaatc tccaggcacc catgtacttt      360

ttcatctgta gcttggccat atctgatatg ctgggcagcc tatataagat cttggaaaat      420

atcctgatca tattgagaaa catgggctat ctcaagccac gtggcagttt tgaaaccaca      480

gccgatgaca tcatcgactc cctgtttgtc ctctccctgc ttggctccat cttcagcctg      540

tctgtgattg ctgcggaccg ctacatcacc atcttccacg cactgcggta ccacagcatc      600

gtgaccatgc gccgcactgt ggtggtgctt acggtcatct ggacgttctg cacggggact      660

ggcatcacca tggtgatctt ctcccatcat gtgcccacag tgatcacctt cacgtcgctg      720

ttcccgctga tgctggtctt catcctgtgc ctctatgtgc acatgttcct gctggctcga      780

tcccacacca ggaagatctc caccctcccc agagccaaca tgaaaggggc catcacactg      840

accatcctgc tcggggtctt catcttctgc tgggccccct ttgtgcttca tgtcctcttg      900

atgacattct gcccaagtaa cccctactgc gcctgctaca tgtctctctt ccaggtgaac      960

ggcatgttga tcatgtgcaa tgccgtcatt gaccccttca tatatgcctt ccggagccca     1020

gagctcaggg acgcattcaa aaagatgatc ttctgcagca ggtactggta gaatggctga     1080

tccctggttt tagaatccat gggaataacg ttgccaagtg ccagaatagt gtaacattcc     1140

aacaaatgcc agtgctcctc actggccttc cttccctaat ggatgcaagg atgatcccac     1200

cagctagtgt ttctaatagc taggttctat gtgaacagtc ttattgtagg ggcaacctct     1260

taactttgtg actggacaga taaaacgatg tagtaaaaga aggatagaat acaaagtatt     1320

aggtaggtac aaaagtaatt aaggtttttg ccattacttt caatgaccaa aaattgcaat     1380

tacttttgca ccaatctagt aaaacagcaa taaaaattca agggctttgg gctaaggcaa     1440

agacttgctt tcctgtggac atctaacaag ccagttctga ggtggccttt ccaggtggag     1500

gccattgcag ccaatttcca gaagttaagt acctggacat gcgactccag gcagaagatg     1560

tagggtctct gtaagccaat aataaattgg aaggaatgca ttgctgcagc tgaatttgtc     1620

tgtctcccac agccatgtgg aatctccacc ctcctctttc tccctgttag tctgatgtat     1680

tgatgccacc tcagtttcag aaagtaggct gagtataaac tataaatgtc aaataacgag     1740

cttcgagttt ccaatgataa atggaccttc tctgttagtc ttctttgctc actcagtatc     1800

ccactggcct taaaaccctt tcctgttaca tttcctcatg ctttatgagc atacatttca     1860

aaggaagaaa tgaaaattta atccatttag ttcccatgtg ggaatacata aaggccagat     1920

gaaaattgtc actatttgaa gaagctgtaa ccaaactatg tgtgttacaa tgtagaagta     1980

caagaaaaga gccccaacat gtattttaag aaataaagag agagagacag agacagacag     2040

agagagagag agagagagag agagagagtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     2100

tgtgtgtgtg tgtgtgtgta ttttccccat gcttttggac tatggggaaa accaaaacca     2160

aagcaagaca tcaagcaatg gtgctgttat tatagcccca agtcaaagac ctgagggagg     2220

caaacaccac ctcattctgc agatgaatgt gaaagcagac ccagtcactg ggaaatgtca     2280

tcctcccatc agccaagatg ccagcaatgg aagagtggca accccagtag gaataaaaga     2340

aacataattt gcaagttcat tcatttttaa tagctaaaaa tcagcttaaa ggagaagcac     2400

atcctgattg taagtcccca ctaagttgga gggtgacttg aatggggtga aaggtgaaag     2460

ggacagagga gagcagtggg gcttcagagg ccaccaggct caggatctgc aggatggatg     2520

gtatcttcca gaacaggcaa tgctttgccc tcaggagaat ttcccagagc tgctgagggg     2580

agaagacagc cacacacagg acagaccatt tggtgatggg tttgatatta gaagtggcag     2640

ggacaggaac ttcagaagca aaggaggcaa ggcagctgga gtcaagtgag gacagtggca     2700

ggcgtgcttt cacatggcct gtcccacaga tggaggtgaa aggtgcacct tcttgtcctc     2760

tgttctgtag aaatccttcc ctgtttgatc cttcccctgc caaatgaact atgttactct     2820

aatactaacc tgtattaatt aatatatgag atatatataa gttaattttt catgaaatct     2880

aaagcacaac cctagaacta atttttaaaa gtgttatttc taccattgaa aaagtaatgt     2940

ataacatatt ttatgtgatt aaagtgcgta ttctcaataa gaggtaacct ttttttgatg     3000

ctgcaatgct ctgtgatacc acagaggtaa gcaatgccac ttaacctgta tcataaatag     3060

tcccaaactg ctcttcctat aaaattctgc ctttgtcaac agctttgctg tctcctaatc     3120

actctcaagc tctctgctgt gcatgtgact gttgtcagaa ggaaaatcac caagaaactt     3180

cacctctcac tgcctttgat ttgttgcagt taatctaaga aacaaaatga agatggctag     3240

tctaatggtg gatgaaacaa aaatgaagtc tgagtgctaa ttcagagaac ttgcaattcc     3300

agacattttc aattctaggt cttctgctat attccaatca gaacagaagc ttcagggctc     3360

atagttactg agaaaactca cgtttttcta cctctaactt catatagaat tccaaatgaa     3420

agcaccacca aactgcacat atttgtgtga ggaagatcaa caagcttcag acttttccca     3480

tgaggactta attcttttat caaattaccc aatttttaaa ctgctgtgtg gatactgtga     3540

gtgttcagct ttatcgatga cctagccttg gaccagatag ctgaaaatgt tcaggatgtg     3600

tactcaagct gatagtaatt ctgagccctg tctaataaaa aaggaaggat gt             3652


<210>  8
<211>  1137
<212>  DNA
<213>  homo sapiens

<400>  8
atggtctggg ggaaaatttg ctggttcagc cagagggctg gatggacagt gtttgctgag       60

tcacagatat ctctctcatg tagcctttgt ctccacagtg gtgaccagga ggcacagaac      120

ccaaacctgg tatctcagct ctgtggcgtc tttcttcaaa atgagacgaa tgaaaccata      180

catatgcaga tgagcatggc agtgggacag caggccctgc ccttgaatat cattgccccc      240

aaggctgtgc tggtctccct ctgtggggtc ttattgaatg gcactgtctt ctggctgctt      300

tgctgtgggg ccacgaatcc ctacatggta tacatcctcc acctggtcgc tgctgacgtg      360

atctatcttt gctgctcggc agtggggttc ttacaggtga ctctgctaac ttatcatgga      420

gtcgtgtttt ttatccctga tttcctggcc atattgtctc ccttctcctt tgaggtgtgt      480

ctctgtctcc tggtggccat cagcacagag cggtgtgtgt gtgtcctctt ccccatctgg      540

tacagatgcc accgcccaaa atacacatct aatgttgtct gcaccctcat ctggggcctg      600

cctttttgca tcaacatagt aaaatcactt ttcctaactt actggaaaca tgtaaaggca      660

tgtgtcatat ttctaaagct ttctgggctc ttccatgcta tcctttcact tgtgatgtgt      720

gtgtcgagtc tgactctact cattagattc ctgtgctgct cccagcagca aaaggccacc      780

agggtctatg cggtggtgca gatctcggcc cccatgttcc tactctgggc cctacccctg      840

agcgtggcac ccctcataac agatttcaaa atgtttgtca ccacctccta tttaatttcc      900

ttgttcctca ttataaacag cagcgccaac cctatcattt atttctttgt ggggagcctc      960

agaaagaaaa ggctgaagga atctctcaga gtgattctcc aacgggcgtt agcagataag     1020

ccagaggtgg ggaggaacaa aaaggcagct ggcatcgacc caatggagca accacactct     1080

actcagcatg tggagaacct tcttcccagg gagcacaggg tcgatgtgga aacataa        1137


<210>  9
<211>  9239
<212>  DNA
<213>  homo sapiens

<400>  9
gcgctggctg cgggcggtga gctgagctcg cccccgggga gctgtggccg gcgcccctgc       60

cggttccctg agcagcggac gttcatgctg ggagggcggc gggttggaag caggtgccac      120

catggctagt ggcagctgtc aggggtgcga agaggacgag gaaactctga agaagttgat      180

agtcaggctg aacaatgtcc aggaaggaaa acagatagaa acgctggtcc aaatcctgga      240

ggatctgctg gtgttcacgt actccgagca cgcctccaag ttatttcaag gcaaaaatat      300

ccatgtgcct ctgttgatcg tcttggactc ctatatgaga gtcgcgagtg tgcagcaggt      360

gggttggtca cttctgtgca aattaataga agtctgtcca ggtacaatgc aaagcttaat      420

gggaccccag gatgttggaa atgattggga agtccttggt gttcaccaat tgattcttaa      480

aatgctaaca gttcataatg ccagtgtaaa cttgtcagtg attggactga agaccttaga      540

tctcctccta acttcaggta aaatcacctt gctgatattg gatgaagaaa gtgatatttt      600

catgttaatt tttgatgcca tgcactcatt tccagccaat gatgaagtcc agaaacttgg      660

atgcaaagct ttacatgtgc tgtttgagag agtctcagag gagcaactga ctgaatttgt      720

tgagaacaaa gattatatga tattgttaag tgcgttaaca aattttaaag atgaagagga      780

aattgtgctt catgtgctgc attgtttaca ttccctagcg attccttgca ataatgtgga      840

agtcctcatg agtggcaatg tcaggtgtta taatattgtg gtggaagcta tgaaagcatt      900

ccctatgagt gaaagaattc aagaagtgag ttgctgtttg ctccataggc ttacattagg      960

taattttttc aatatcctgg tattaaacga agtccatgag tttgtggtga aagctgtgca     1020

gcagtaccca gagaatgcag cattgcagat ctcagcgctc agctgtttgg ccctcctcac     1080

tgagactatt ttcttaaatc aagatttaga ggaaaagaat gagaatcaag agaatgatga     1140

tgagggggaa gaagataaat tgttttggct ggaagcctgt tacaaagcat taacgtggca     1200

tagaaagaac aagcacgtgc aggaggccgc atgctgggca ctaaataatc tccttatgta     1260

ccaaaacagt ttacatgaga agattggaga tgaagatggc catttcccag ctcataggga     1320

agtgatgctc tccatgctga tgcattcttc atcaaaggaa gttttccagg catctgcgaa     1380

tgcattgtca actctcttag aacaaaatgt taatttcaga aaaatactgt tatcaaaagg     1440

aatacacctg aatgttttgg agttaatgca gaagcatata cattctcctg aagtggctga     1500

aagtggctgt aaaatgctaa atcatctttt tgaaggaagc aacacttccc tggatataat     1560

ggcagcagtg gtccccaaaa tactaacagt tatgaaacgt catgagacat cattaccagt     1620

gcagctggag gcgcttcgag ctattttaca ttttatagtg cctggcatgc cagaagaatc     1680

cagggaggat acagaatttc atcataagct aaatatggtt aaaaaacagt gtttcaagaa     1740

tgatattcac aaactggtcc tagcagcttt gaacaggttc attggaaatc ctgggattca     1800

gaaatgtgga ttaaaagtaa tttcttctat tgtacatttt cctgatgcat tagagatgtt     1860

atccctggaa ggtgctatgg attcagtgct tcacacactg cagatgtatc cagatgacca     1920

agaaattcag tgtctgggtt taagtcttat aggatacttg attacaaaga agaatgtgtt     1980

cataggaact ggacatctgc tggcaaaaat tctggtttcc agcttatacc gatttaagga     2040

tgttgctgaa atacagacta aaggatttca gacaatctta gcaatcctca aattgtcagc     2100

atctttttct aagctgctgg tgcatcattc atttgactta gtaatattcc atcaaatgtc     2160

ttccaatatc atggaacaaa aggatcaaca gtttctaaac ctctgttgca agtgttttgc     2220

aaaagtagct atggatgatt acttaaaaaa tgtgatgcta gagagagcgt gtgatcagaa     2280

taacagcatc atggttgaat gcttgcttct attgggagca gatgccaatc aagcaaagga     2340

gggatcttct ttaatttgtc aggtatgtga gaaagagagc agtcccaaat tggtggaact     2400

cttactgaat agtggatctc gtgaacaaga tgtacgaaaa gcgttgacga taagcattgg     2460

gaaaggtgac agccagatca tcagcttgct cttaaggagg ctggccctgg atgtggccaa     2520

caatagcatt tgccttggag gattttgtat aggaaaagtt gaaccttctt ggcttggtcc     2580

tttatttcca gataagactt ctaatttaag gaaacaaaca aatatagcat ctacactagc     2640

aagaatggtg atcagatatc agatgaaaag tgctgtggaa gaaggaacag cctcaggcag     2700

cgatggaaat ttttctgaag atgtgctgtc taaatttgat gaatggacct ttattcctga     2760

ctcttctatg gacagtgtgt ttgctcaaag tgatgacctg gatagtgaag gaagtgaagg     2820

ctcatttctt gtgaaaaaga aatctaattc aattagtgta ggagaatttt accgagatgc     2880

cgtattacag cgttgctcac caaatttgca aagacattcc aattccttgg ggcccatttt     2940

tgatcatgaa gatttactga agcgaaaaag aaaaatatta tcttcagatg attcactcag     3000

gtcatcaaaa cttcaatccc atatgaggca ttcagacagc atttcttctc tggcttctga     3060

gagagaatat attacatcac tagacctttc agcaaatgaa ctaagagata ttgatgccct     3120

aagccagaaa tgctgtataa gtgttcattt ggagcatctt gaaaagctgg agcttcacca     3180

gaatgcactc acgagctttc cacaacagct atgtgaaact ctgaagagtt tgacacattt     3240

ggacttgcac agtaataaat ttacatcatt tccttcttat ttgttgaaaa tgagttgtat     3300

tgctaatctt gatgtctctc gaaatgacat tggaccctca gtggttttag atcctacagt     3360

gaaatgtcca actctgaaac agtttaacct gtcatataac cagctgtctt ttgtacctga     3420

gaacctcact gatgtggtag agaaactgga gcagctcatt ttagaaggaa ataaaatatc     3480

agggatatgc tcccccttga gactgaagga actgaagatt ttaaacctta gtaagaacca     3540

catttcatcc ctatcagaga actttcttga ggcttgtcct aaagtggaga gtttcagtgc     3600

cagaatgaat tttcttgctg ctatgccttt cttgcctcct tctatgacaa tcctaaaatt     3660

atctcagaac aaattttcct gtattccaga agcaatttta aatcttccac acttgcggtc     3720

tttagatatg agcagcaatg atattcagta cctaccaggt cccgcacact ggaaatcttt     3780

gaacttaagg gaactcttat ttagccataa tcagatcagc atcttggact tgagtgaaaa     3840

agcatattta tggtctagag tagagaaact gcatctttct cacaataaac tgaaagagat     3900

tcctcctgag attggctgtc ttgaaaatct gacatctctg gatgtcagtt acaacttgga     3960

actaagatcc tttcccaatg aaatggggaa attaagcaaa atatgggatc ttcctttgga     4020

tgaactgcat cttaactttg attttaaaca tataggatgt aaagccaaag acatcataag     4080

gtttcttcaa cagcgattaa aaaaggctgt gccttataac cgaatgaaac ttatgattgt     4140

gggaaatact gggagtggta aaaccacctt attgcagcaa ttaatgaaaa ccaagaaatc     4200

agatcttgga atgcaaagtg ccacagttgg catagatgtg aaagactggc ctatccaaat     4260

aagagacaaa agaaagagag atctcgtcct aaatgtgtgg gattttgcag gtcgtgagga     4320

attctatagt actcatcccc attttatgac gcagcgagca ttgtaccttg ctgtctatga     4380

cctcagcaag ggacaggctg aagttgatgc catgaagcct tggctcttca atataaaggc     4440

tcgcgcttct tcttcccctg tgattctcgt tggcacacat ttggatgttt ctgatgagaa     4500

gcaacgcaaa gcctgcatga gtaaaatcac caaggaactc ctgaataagc gagggttccc     4560

tgccatacga gattaccact ttgtgaatgc caccgaggaa tctgatgctt tggcaaaact     4620

tcggaaaacc atcataaacg agagccttaa tttcaagatc cgagatcagc ttgttgttgg     4680

acagctgatt ccagactgct atgtagaact tgaaaaaatc attttatcgg agcgtaaaaa     4740

tgtgccaatt gaatttcccg taattgaccg gaaacgatta ttacaactag tgagagaaaa     4800

tcagctgcag ttagatgaaa atgagcttcc tcacgcagtt cactttctaa atgaatcagg     4860

agtccttctt cattttcaag acccagcact gcagttaagt gacttgtact ttgtggaacc     4920

caagtggctt tgtaaaatca tggcacagat tttgacagtg aaagtggaag gttgtccaaa     4980

acaccctaag ggcattattt cgcgtagaga tgtggaaaaa tttctttcaa aaaaaaggaa     5040

atttccaaag aactacatgt cacagtattt taagctccta gaaaaattcc agattgcttt     5100

gccaatagga gaagaatatt tgctggttcc aagcagtttg tctgaccaca ggcctgtgat     5160

agagcttccc cattgtgaga actctgaaat tatcatccga ctatatgaaa tgccttattt     5220

tccaatggga ttttggtcaa gattaatcaa tcgattactt gagatttcac cttacatgct     5280

ttcagggaga gaacgagcac ttcgcccaaa cagaatgtat tggcgacaag gcatttactt     5340

aaattggtct cctgaagctt attgtctggt aggatctgaa gtcttagaca atcatccaga     5400

gagtttctta aaaattacag ttccttcttg tagaaaaggc tgtattcttt tgggccaagt     5460

tgtggaccac attgattctc tcatggaaga atggtttcct gggttgctgg agattgatat     5520

ttgtggtgaa ggagaaactc tgttgaagaa atgggcatta tatagtttta atgatggtga     5580

agaacatcaa aaaatcttac ttgatgactt gatgaagaaa gcagaggaag gagatctctt     5640

agtaaatcca gatcaaccaa ggctcaccat tccaatatct cagattgccc ctgacttgat     5700

tttggctgac ctgcctagaa atattatgtt gaataatgat gagttggaat ttgaacaagc     5760

tccagagttt ctcctaggtg atggcagttt tggatcagtt taccgagcag cctatgaagg     5820

agaagaagtg gctgtgaaga tttttaataa acatacatca ctcaggctgt taagacaaga     5880

gcttgtggtg ctttgccacc tccaccaccc cagtttgata tctttgctgg cagctgggat     5940

tcgtccccgg atgttggtga tggagttagc ctccaagggt tccttggatc gcctgcttca     6000

gcaggacaaa gccagcctca ctagaaccct acagcacagg attgcactcc acgtagctga     6060

tggtttgaga tacctccact cagccatgat tatataccga gacctgaaac cccacaatgt     6120

gctgcttttc acactgtatc ccaatgctgc catcattgca aagattgctg actacggcat     6180

tgctcagtac tgctgtagaa tggggataaa aacatcagag ggcacaccag ggtttcgtgc     6240

acctgaagtt gccagaggaa atgtcattta taaccaacag gctgatgttt attcatttgg     6300

tttactactc tatgacattt tgacaactgg aggtagaata gtagagggtt tgaagtttcc     6360

aaatgagttt gatgaattag aaatacaagg aaaattacct gatccagtta aagaatatgg     6420

ttgtgcccca tggcctatgg ttgagaaatt aattaaacag tgtttgaaag aaaatcctca     6480

agaaaggcct acttctgccc aggtctttga cattttgaat tcagctgaat tagtctgtct     6540

gacgagacgc attttattac ctaaaaacgt aattgttgaa tgcatggttg ctacacatca     6600

caacagcagg aatgcaagca tttggctggg ctgtgggcac accgacagag gacagctctc     6660

atttcttgac ttaaatactg aaggatacac ttctgaggaa gttgctgata gtagaatatt     6720

gtgcttagcc ttggtgcatc ttcctgttga aaaggaaagc tggattgtgt ctgggacaca     6780

gtctggtact ctcctggtca tcaataccga agatgggaaa aagagacata ccctagaaaa     6840

gatgactgat tctgtcactt gtttgtattg caattccttt tccaagcaaa gcaaacaaaa     6900

aaattttctt ttggttggaa ccgctgatgg caagttagca atttttgaag ataagactgt     6960

taagcttaaa ggagctgctc ctttgaagat actaaatata ggaaatgtca gtactccatt     7020

gatgtgtttg agtgaatcca caaattcaac ggaaagaaat gtaatgtggg gaggatgtgg     7080

cacaaagatt ttctcctttt ctaatgattt caccattcag aaactcattg agacaagaac     7140

aagccaactg ttttcttatg cagctttcag tgattccaac atcataacag tggtggtaga     7200

cactgctctc tatattgcta agcaaaatag ccctgttgtg gaagtgtggg ataagaaaac     7260

tgaaaaactc tgtggactaa tagactgcgt gcacttttta agggaggtaa tggtaaaaga     7320

aaacaaggaa tcaaaacaca aaatgtctta ttctgggaga gtgaaaaccc tctgccttca     7380

gaagaacact gctctttgga taggaactgg aggaggccat attttactcc tggatctttc     7440

aactcgtcga cttatacgtg taatttacaa cttttgtaat tcggtcagag tcatgatgac     7500

agcacagcta ggaagcctta aaaatgtcat gctggtattg ggctacaacc ggaaaaatac     7560

tgaaggtaca caaaagcaga aagagataca atcttgcttg accgtttggg acatcaatct     7620

tccacatgaa gtgcaaaatt tagaaaaaca cattgaagtg agaaaagaat tagctgaaaa     7680

aatgagacga acatctgttg agtaagagag aaataggaat tgtctttgga taggaaaatt     7740

attctctcct cttgtaaata tttattttaa aaatgttcac atggaaaggg tactcacatt     7800

ttttgaaata gctcgtgtgt atgaaggaat gttattattt ttaatttaaa tatatgtaaa     7860

aatacttacc agtaaatgtg tattttaaag aactatttaa aacacaatgt tatatttctt     7920

ataaatacca gttactttcg ttcattaatt aatgaaaata aatctgtgaa gtacctaatt     7980

taagtactca tactaaaatt tataaggccg ataatttttt gttttcttgt ctgtaatgga     8040

ggtaaacttt attttaaatt ctgtgcttaa gacaggacta ttgcttgtcg atttttctag     8100

aaatctgcac ggtataatga aaatattaag acagtttccc atgtaatgta ttccttctta     8160

gattgcatcg aaatgcacta tcatatatgc ttgtaaatat tcaaatgaat ttgcactaat     8220

aaagtccttt gttggtatgt gaattctctt tgttgctgtt gcaaacagtg catcttacac     8280

aacttcactc aattcaaaag aaaactccat taaaagtact aatgaaaaaa catgacatac     8340

tgtcaaagtc ctcatatcta ggaaagacac agaaactctc tttgtcacag aaactctctg     8400

tgtctttcct agacataata gagttgtttt tcaactctat gtttgaatgt ggataccctg     8460

aattttgtat aattagtgta aatacagtgt tcagtccttc aagtgatatt tttatttttt     8520

tattcatacc actagctact tgttttctaa tctgcttcat tctaatgctt atattcatct     8580

tttccctaaa tttgtgatgc tgcagatcct acatcattca gatagaaacc tttttttttt     8640

tcagaattat agaattccac agctcctacc aagaccatga ggataaatat ctaacacttt     8700

tcagttgctg aaggagaaag gagctttagt tatgatggat aaaaatatct gccaccctag     8760

gcttccaaat tatacttaaa ttgtttacat agcttaccac aataggagta tcagggccaa     8820

atacctatgt aataatttga ggtcatttct gctttaggaa aagtactttc ggtaaattct     8880

ttggccctga ccagtattca ttatttcaga taattccctg tgataggaca actagtacat     8940

ttaatattct cagaacttat ggcattttac tatgtgaaaa ctttaaattt atttatatta     9000

agggtaatca aattcttaaa gatgaaagat tttctgtatt ttaaaggaag ctatgcttta     9060

acttgttatg taattaacaa aaaaatcata tataatagag ctctttgttc cagtgttatc     9120

tctttcattg ttactttgta tttgcaattt tttttaccaa agacaaatta aaaaaatgaa     9180

taccatattt aaatggaata ataaaggttt tttaaaaact ttaaaaaaaa aaaaaaaaa      9239


<210>  10
<211>  5100
<212>  DNA
<213>  homo sapiens

<400>  10
cttgttgact aggcgctgtt cttgctggct ggtgccccag ggcctggaga ggtctgaaga       60

aacctgggag ccagcagccc ggggctccac tctgggttct gaaagcccat tccctgctct      120

gcggctcctc ccaccccacc tcttctcagc cttgcagctc aagggttgat ctcaggagtc      180

caggacccag gagagggaag aatctgagga acacagaaca gtgagcgttg cccacacccc      240

atctcccgtc accacatctc ccctcaccct caccctccct gcctggccct ggaccccatc      300

ccaggacctc cctatcagct gacttcttcc agtgtcttgc aggcccctct gggctcctcc      360

ctcccctggc ttttcctacc actccccctc tatcggcgtc tatctgtagg tgccctggga      420

tttataaaac tgggttccga atgctgaata agagacggta agagccaagg caaaggacag      480

cactgttctc tgcctgcctg ataccctcac cacctgggaa catcccccag acaccctctt      540

aactccggga cagagatggc tggcggagcc tggggccgcc tggcctgtta cttggagttc      600

ctgaagaagg aggagctgaa ggagttccag cttctgctcg ccaataaagc gcactccagg      660

agctcttcgg gtgagacacc cgctcagcca gagaagacga gtggcatgga ggtggcctcg      720

tacctggtgg ctcagtatgg ggagcagcgg gcctgggacc tagccctcca tacctgggag      780

cagatggggc tgaggtcact gtgcgcccaa gcccaggaag gggcaggcca ctctccctca      840

ttcccctaca gcccaagtga accccacctg gggtctccca gccaacccac ctccaccgca      900

gtgctaatgc cctggatcca tgaattgccg gcggggtgca cccagggctc agagagaagg      960

gttttgagac agctgcctga cacatctgga cgccgctgga gagaaatctc tgcctcactc     1020

ctctaccaag ctcttccaag ctccccagac catgagtctc caagccagga gtcacccaac     1080

gcccccacat ccacagcagt gctggggagc tggggatccc cacctcagcc cagcctagca     1140

cccagagagc aggaggctcc tgggacccaa tggcctctgg atgaaacgtc aggaatttac     1200

tacacagaaa tcagagaaag agagagagag aaatcagaga aaggcaggcc cccatgggca     1260

gcggtggtag gaacgccccc acaggcgcac accagcctac agccccacca ccacccatgg     1320

gagccttctg tgagagagag cctctgttcc acatggccct ggaaaaatga ggattttaac     1380

caaaaattca cacagctgct acttctacaa agacctcacc ccagaagcca agatcccctg     1440

gtcaagagaa gctggcctga ttatgtggag gagaatcgag gacatttaat tgagatcaga     1500

gacttatttg gcccaggcct ggatacccaa gaacctcgca tagtcatact gcagggggct     1560

gctggaattg ggaagtcaac actggccagg caggtgaagg aagcctgggg gagaggccag     1620

ctgtatgggg accgcttcca gcatgtcttc tacttcagct gcagagagct ggcccagtcc     1680

aaggtggtga gtctcgctga gctcatcgga aaagatggga cagccactcc ggctcccatt     1740

agacagatcc tgtctaggcc agagcggctg ctcttcatcc tcgatggtgt agatgagcca     1800

ggatgggtct tgcaggagcc gagttctgag ctctgtctgc actggagcca gccacagccg     1860

gcggatgcac tgctgggcag tttgctgggg aaaactatac ttcccgaggc atccttcctg     1920

atcacggctc ggaccacagc tctgcagaac ctcattcctt ctttggagca ggcacgttgg     1980

gtagaggtcc tggggttctc tgagtccagc aggaaggaat atttctacag atatttcaca     2040

gatgaaaggc aagcaattag agcctttagg ttggtcaaat caaacaaaga gctctgggcc     2100

ctgtgtcttg tgccctgggt gtcctggctg gcctgcactt gcctgatgca gcagatgaag     2160

cggaaggaaa aactcacact gacttccaag accaccacaa ccctctgtct acattacctt     2220

gcccaggctc tccaagctca gccattggga ccccagctca gagacctctg ctctctggct     2280

gctgagggca tctggcaaaa aaagaccctt ttcagtccag atgacctcag gaagcatggg     2340

ttagatgggg ccatcatctc caccttcttg aagatgggta ttcttcaaga gcaccccatc     2400

cctctgagct acagcttcat tcacctctgt ttccaagagt tctttgcagc aatgtcctat     2460

gtcttggagg atgagaaggg gagaggtaaa cattctaatt gcatcataga tttggaaaag     2520

acgctagaag catatggaat acatggcctg tttggggcat caaccacacg tttcctattg     2580

ggcctgttaa gtgatgaggg ggagagagag atggagaaca tctttcactg ccggctgtct     2640

caggggagga acctgatgca gtgggtcccg tccctgcagc tgctgctgca gccacactct     2700

ctggagtccc tccactgctt gtacgagact cggaacaaaa cgttcctgac acaagtgatg     2760

gcccatttcg aagaaatggg catgtgtgta gaaacagaca tggagctctt agtgtgcact     2820

ttctgcatta aattcagccg ccacgtgaag aagcttcagc tgattgaggg caggcagcac     2880

agatcaacat ggagccccac catggtagtc ctgttcaggt gggtcccagt cacagatgcc     2940

tattggcaga ttctcttctc cgtcctcaag gtcaccagaa acctgaagga gctggaccta     3000

agtggaaact cgctgagcca ctctgcagtg aagagtcttt gtaagaccct gagacgccct     3060

cgctgcctcc tggagaccct gcggttggct ggctgtggcc tcacagctga ggactgcaag     3120

gaccttgcct ttgggctgag agccaaccag accctgaccg agctggacct gagcttcaat     3180

gtgctcacgg atgctggagc caaacacctt tgccagagac tgagacagcc gagctgcaag     3240

ctacagcgac tgcagctggt cagctgtggc ctcacgtctg actgctgcca ggacctggcc     3300

tctgtgctta gtgccagccc cagcctgaag gagctagacc tgcagcagaa caacctggat     3360

gacgttggcg tgcgactgct ctgtgagggg ctcaggcatc ctgcctgcaa actcatacgc     3420

ctggggctgg accagacaac tctgagtgat gagatgaggc aggaactgag ggccctggag     3480

caggagaaac ctcagctgct catcttcagc agacggaaac caagtgtgat gacccctact     3540

gagggcctgg atacgggaga gatgagtaat agcacatcct cactcaagcg gcagagactc     3600

ggatcagaga gggcggcttc ccatgttgct caggctaatc tcaaactcct ggacgtgagc     3660

aagatcttcc caattgctga gattgcaggc aagagccacg aggaaagctc cccagaggta     3720

gtaccggtgg aactcttgtg cgtgccttct cctgcctctc aaggggacct gcatacgaag     3780

cctttgggga ctgacgatga cttctggggc cccacggggc ctgtggctac tgaggtagtt     3840

gacaaagaaa agaacttgta ccgagttcac ttccctgtag ctggctccta ccgctggccc     3900

aacacgggtc tctgctttgt gatgagagaa gcggtgaccg ttgagattga attctgtgtg     3960

tgggaccagt tcctgggtga gatcaaccca cagcacagct ggatggtggc agggcctctg     4020

ctggacatca aggctgagcc tggagctgtg gaagctgtgc acctccctca ctttgtggct     4080

ctccaagggg gccatgtgga cacatccctg ttccaaatgg cccactttaa agaggagggg     4140

atgctcctgg agaagccagc cagggtggag ctgcatcaca tagttctgga aaaccccagc     4200

ttctccccct tgggagtcct cctgaaaatg atccataatg ccctgcgctt cattcccgtc     4260

acctctgtgg tgttgcttta ccaccgcgtc catcctgagg aagtcacctt ccacctctac     4320

ctgatcccaa gtgactgctc cattcggaag gccatagatg atctagaaat gaaattccag     4380

tttgtgcgaa tccacaagcc acccccgctg accccacttt atatgggctg tcgttacact     4440

gtgtctgggt ctggttcagg gatgctggaa atactcccca aggaactgga gctctgctat     4500

cgaagccctg gagaagacca gctgttctcg gagttctacg ttggccactt gggatcaggg     4560

atcaggctgc aagtgaaaga caagaaagat gagactctgg tgtgggaggc cttggtgaaa     4620

ccaggaagga acaccagcca gccgtggaac ctcaggtgca acagagacgc caggagatac     4680

tagtgcccag cagcctgcgg cagtaccaat gaagccagag agggcttggt ggatgacaag     4740

gaggcctgag tagaccgcag gtgggtctga gaaatgggct taggtgaggc aggtctttga     4800

aggatttgtt cttaatcata tgcgagatgc tcaaaaggct ggatgcctgc ttttgtgggt     4860

gaagagcaag aagagaaaac aggttgtaca catacagatg cagatggaga gacagagaaa     4920

aaaaaggaag aaggcagaga aatgcaccaa ttcttgagct gtattatctc tggaccttgg     4980

gattgtggga ggctttattt tactactgat tttgcctaca ctgttttctc aatttctagt     5040

tttctacaaa gatgatgtgt tagctttttc acgcattaag attaaaattt aaaacagaaa     5100


<210>  11
<211>  5491
<212>  DNA
<213>  homo sapiens

<400>  11
cttgttgact aggcgctgtt cttgctggct ggtgccccag ggcctggaga ggtctgaaga       60

aacctgggag ccagcagccc ggggctccac tctgggttct gaaagcccat tccctgctct      120

gcggctcctc ccaccccacc tcttctcagc cttgcagctc aagggttgat ctcaggagtc      180

caggacccag gagagggaag aatctgagga acacagaaca gtgagcgttg cccacacccc      240

atctcccgtc accacatctc ccctcaccct caccctccct gcctggccct ggaccccatc      300

ccaggacctc cctatcagct gacttcttcc agtgtcttgc aggcccctct gggctcctcc      360

ctcccctggc ttttcctacc actccccctc tatcggcgtc tatctgtagg tgccctggga      420

tttataaaac tgggttccga atgctgaata agagacggta agagccaagg caaaggacag      480

cactgttctc tgcctgcctg ataccctcac cacctgggaa catcccccag acaccctctt      540

aactccggga cagagatggc tggcggagcc tggggccgcc tggcctgtta cttggagttc      600

ctgaagaagg aggagctgaa ggagttccag cttctgctcg ccaataaagc gcactccagg      660

agctcttcgg gtgagacacc cgctcagcca gagaagacga gtggcatgga ggtggcctcg      720

tacctggtgg ctcagtatgg ggagcagcgg gcctgggacc tagccctcca tacctgggag      780

cagatggggc tgaggtcact gtgcgcccaa gcccaggaag gggcaggcca ctctccctca      840

ttcccctaca gcccaagtga accccacctg gggtctccca gccaacccac ctccaccgca      900

gtgctaatgc cctggatcca tgaattgccg gcggggtgca cccagggctc agagagaagg      960

gttttgagac agctgcctga cacatctgga cgccgctgga gagaaatctc tgcctcactc     1020

ctctaccaag ctcttccaag ctccccagac catgagtctc caagccagga gtcacccaac     1080

gcccccacat ccacagcagt gctggggagc tggggatccc cacctcagcc cagcctagca     1140

cccagagagc aggaggctcc tgggacccaa tggcctctgg atgaaacgtc aggaatttac     1200

tacacagaaa tcagagaaag agagagagag aaatcagaga aaggcaggcc cccatgggca     1260

gcggtggtag gaacgccccc acaggcgcac accagcctac agccccacca ccacccatgg     1320

gagccttctg tgagagagag cctctgttcc acatggccct ggaaaaatga ggattttaac     1380

caaaaattca cacagctgct acttctacaa agacctcacc ccagaagcca agatcccctg     1440

gtcaagagaa gctggcctga ttatgtggag gagaatcgag gacatttaat tgagatcaga     1500

gacttatttg gcccaggcct ggatacccaa gaacctcgca tagtcatact gcagggggct     1560

gctggaattg ggaagtcaac actggccagg caggtgaagg aagcctgggg gagaggccag     1620

ctgtatgggg accgcttcca gcatgtcttc tacttcagct gcagagagct ggcccagtcc     1680

aaggtggtga gtctcgctga gctcatcgga aaagatggga cagccactcc ggctcccatt     1740

agacagatcc tgtctaggcc agagcggctg ctcttcatcc tcgatggtgt agatgagcca     1800

ggatgggtct tgcaggagcc gagttctgag ctctgtctgc actggagcca gccacagccg     1860

gcggatgcac tgctgggcag tttgctgggg aaaactatac ttcccgaggc atccttcctg     1920

atcacggctc ggaccacagc tctgcagaac ctcattcctt ctttggagca ggcacgttgg     1980

gtagaggtcc tggggttctc tgagtccagc aggaaggaat atttctacag atatttcaca     2040

gatgaaaggc aagcaattag agcctttagg ttggtcaaat caaacaaaga gctctgggcc     2100

ctgtgtcttg tgccctgggt gtcctggctg gcctgcactt gcctgatgca gcagatgaag     2160

cggaaggaaa aactcacact gacttccaag accaccacaa ccctctgtct acattacctt     2220

gcccaggctc tccaagctca gccattggga ccccagctca gagacctctg ctctctggct     2280

gctgagggca tctggcaaaa aaagaccctt ttcagtccag atgacctcag gaagcatggg     2340

ttagatgggg ccatcatctc caccttcttg aagatgggta ttcttcaaga gcaccccatc     2400

cctctgagct acagcttcat tcacctctgt ttccaagagt tctttgcagc aatgtcctat     2460

gtcttggagg atgagaaggg gagaggtaaa cattctaatt gcatcataga tttggaaaag     2520

acgctagaag catatggaat acatggcctg tttggggcat caaccacacg tttcctattg     2580

ggcctgttaa gtgatgaggg ggagagagag atggagaaca tctttcactg ccggctgtct     2640

caggggagga acctgatgca gtgggtcccg tccctgcagc tgctgctgca gccacactct     2700

ctggagtccc tccactgctt gtacgagact cggaacaaaa cgttcctgac acaagtgatg     2760

gcccatttcg aagaaatggg catgtgtgta gaaacagaca tggagctctt agtgtgcact     2820

ttctgcatta aattcagccg ccacgtgaag aagcttcagc tgattgaggg caggcagcac     2880

agatcaacat ggagccccac catggtagtc ctgttcaggt gggtcccagt cacagatgcc     2940

tattggcaga ttctcttctc cgtcctcaag gtcaccagaa acctgaagga gctggaccta     3000

agtggaaact cgctgagcca ctctgcagtg aagagtcttt gtaagaccct gagacgccct     3060

cgctgcctcc tggagaccct gcggttggct ggctgtggcc tcacagctga ggactgcaag     3120

gaccttgcct ttgggctgag agccaaccag accctgaccg agctggacct gagcttcaat     3180

gtgctcacgg atgctggagc caaacacctt tgccagagac tgagacagcc gagctgcaag     3240

ctacagcgac tgcagctggt cagctgtggc ctcacgtctg actgctgcca ggacctggcc     3300

tctgtgctta gtgccagccc cagcctgaag gagctagacc tgcagcagaa caacctggat     3360

gacgttggcg tgcgactgct ctgtgagggg ctcaggcatc ctgcctgcaa actcatacgc     3420

ctggggctgg accagacaac tctgagtgat gagatgaggc aggaactgag ggccctggag     3480

caggagaaac ctcagctgct catcttcagc agacggaaac caagtgtgat gacccctact     3540

gagggcctgg atacgggaga gatgagtaat agcacatcct cactcaagcg gcagagactc     3600

ggatcagaga gggcggcttc ccatgttgct caggctaatc tcaaactcct ggacgtgagc     3660

aagatcttcc caattgctga gattgcagag gaaagctccc cagaggtagt accggtggaa     3720

ctcttgtgcg tgccttctcc tgcctctcaa ggggacctgc atacgaagcc tttggggact     3780

gacgatgact tctggggccc cacggggcct gtggctactg aggtagttga caaagaaaag     3840

aacttgtacc gagttcactt ccctgtagct ggctcctacc gctggcccaa cacgggtctc     3900

tgctttgtga tgagagaagc ggtgaccgtt gagattgaat tctgtgtgtg ggaccagttc     3960

ctgggtgaga tcaacccaca gcacagctgg atggtggcag ggcctctgct ggacatcaag     4020

gctgagcctg gagctgtgga agctgtgcac ctccctcact ttgtggctct ccaagggggc     4080

catgtggaca catccctgtt ccaaatggcc cactttaaag aggaggggat gctcctggag     4140

aagccagcca gggtggagct gcatcacata gttctggaaa accccagctt ctcccccttg     4200

ggagtcctcc tgaaaatgat ccataatgcc ctgcgcttca ttcccgtcac ctctgtggtg     4260

ttgctttacc accgcgtcca tcctgaggaa gtcaccttcc acctctacct gatcccaagt     4320

gactgctcca ttcggaagga actggagctc tgctatcgaa gccctggaga agaccagctg     4380

ttctcggagt tctacgttgg ccacttggga tcagggatca ggctgcaagt gaaagacaag     4440

aaagatgaga ctctggtgtg ggaggccttg gtgaaaccag gagatctcat gcctgcaact     4500

actctgatcc ctccagcccg catagccgta ccttcacctc tggatgcccc gcagttgctg     4560

cactttgtgg accagtatcg agagcagctg atagcccgag tgacatcggt ggaggttgtc     4620

ttggacaaac tgcatggaca ggtgctgagc caggagcagt acgagagggt gctggctgag     4680

aacacgaggc ccagccagat gcggaagctg ttcagcttga gccagtcctg ggaccggaag     4740

tgcaaagatg gactctacca agccctgaag gagacccatc ctcacctcat tatggaactc     4800

tgggagaagg gcagcaaaaa gggactcctg ccactcagca gctgaagtat caacaccagc     4860

ccttgaccct tgagtcctgg ctttggctga cccttctttg ggtctcagtt tctttctctg     4920

caaacaagtt gccatctggt ttgccttcca gcactaaagt aatggaactt tgatgatgcc     4980

tttgctgggc attatgtgtc catgccaggg atgccacagg gggccccagt ccaggtggcc     5040

taacagcatc tcagggaatg tccatctgga gctggcaaga cccctgcaga cctcatagag     5100

cctcatctgg tggccacagc agccaagcct agagccctcc ggatcccatc caggcgcaaa     5160

gaggaatagg agggacatgg aaccatttgc ctctggctgt gtcacagggt gagccccaaa     5220

attggggttc agcgtgggag gccacgtgga ttcttggctt tgtacaggaa gatctacaag     5280

agcaagccaa cagagtaaag tggaaggaag tttattcaga aaataaagga gtatcacagc     5340

tcttttagaa tttgtctagc aggctttcca gtttttacca gaaaacccct ataaattaaa     5400

aattttttac ttaaatttaa gaattaaaaa aatacaaaaa agaaaaaatg aaaataaagg     5460

aataagaagt tacctactcc aaaaaaaaaa a                                    5491


<210>  12
<211>  5623
<212>  DNA
<213>  homo sapiens

<400>  12
cttgttgact aggcgctgtt cttgctggct ggtgccccag ggcctggaga ggtctgaaga       60

aacctgggag ccagcagccc ggggctccac tctgggttct gaaagcccat tccctgctct      120

gcggctcctc ccaccccacc tcttctcagc cttgcagctc aagggttgat ctcaggagtc      180

caggacccag gagagggaag aatctgagga acacagaaca gtgagcgttg cccacacccc      240

atctcccgtc accacatctc ccctcaccct caccctccct gcctggccct ggaccccatc      300

ccaggacctc cctatcagct gacttcttcc agtgtcttgc aggcccctct gggctcctcc      360

ctcccctggc ttttcctacc actccccctc tatcggcgtc tatctgtagg tgccctggga      420

tttataaaac tgggttccga atgctgaata agagacggta agagccaagg caaaggacag      480

cactgttctc tgcctgcctg ataccctcac cacctgggaa catcccccag acaccctctt      540

aactccggga cagagatggc tggcggagcc tggggccgcc tggcctgtta cttggagttc      600

ctgaagaagg aggagctgaa ggagttccag cttctgctcg ccaataaagc gcactccagg      660

agctcttcgg gtgagacacc cgctcagcca gagaagacga gtggcatgga ggtggcctcg      720

tacctggtgg ctcagtatgg ggagcagcgg gcctgggacc tagccctcca tacctgggag      780

cagatggggc tgaggtcact gtgcgcccaa gcccaggaag gggcaggcca ctctccctca      840

ttcccctaca gcccaagtga accccacctg gggtctccca gccaacccac ctccaccgca      900

gtgctaatgc cctggatcca tgaattgccg gcggggtgca cccagggctc agagagaagg      960

gttttgagac agctgcctga cacatctgga cgccgctgga gagaaatctc tgcctcactc     1020

ctctaccaag ctcttccaag ctccccagac catgagtctc caagccagga gtcacccaac     1080

gcccccacat ccacagcagt gctggggagc tggggatccc cacctcagcc cagcctagca     1140

cccagagagc aggaggctcc tgggacccaa tggcctctgg atgaaacgtc aggaatttac     1200

tacacagaaa tcagagaaag agagagagag aaatcagaga aaggcaggcc cccatgggca     1260

gcggtggtag gaacgccccc acaggcgcac accagcctac agccccacca ccacccatgg     1320

gagccttctg tgagagagag cctctgttcc acatggccct ggaaaaatga ggattttaac     1380

caaaaattca cacagctgct acttctacaa agacctcacc ccagaagcca agatcccctg     1440

gtcaagagaa gctggcctga ttatgtggag gagaatcgag gacatttaat tgagatcaga     1500

gacttatttg gcccaggcct ggatacccaa gaacctcgca tagtcatact gcagggggct     1560

gctggaattg ggaagtcaac actggccagg caggtgaagg aagcctgggg gagaggccag     1620

ctgtatgggg accgcttcca gcatgtcttc tacttcagct gcagagagct ggcccagtcc     1680

aaggtggtga gtctcgctga gctcatcgga aaagatggga cagccactcc ggctcccatt     1740

agacagatcc tgtctaggcc agagcggctg ctcttcatcc tcgatggtgt agatgagcca     1800

ggatgggtct tgcaggagcc gagttctgag ctctgtctgc actggagcca gccacagccg     1860

gcggatgcac tgctgggcag tttgctgggg aaaactatac ttcccgaggc atccttcctg     1920

atcacggctc ggaccacagc tctgcagaac ctcattcctt ctttggagca ggcacgttgg     1980

gtagaggtcc tggggttctc tgagtccagc aggaaggaat atttctacag atatttcaca     2040

gatgaaaggc aagcaattag agcctttagg ttggtcaaat caaacaaaga gctctgggcc     2100

ctgtgtcttg tgccctgggt gtcctggctg gcctgcactt gcctgatgca gcagatgaag     2160

cggaaggaaa aactcacact gacttccaag accaccacaa ccctctgtct acattacctt     2220

gcccaggctc tccaagctca gccattggga ccccagctca gagacctctg ctctctggct     2280

gctgagggca tctggcaaaa aaagaccctt ttcagtccag atgacctcag gaagcatggg     2340

ttagatgggg ccatcatctc caccttcttg aagatgggta ttcttcaaga gcaccccatc     2400

cctctgagct acagcttcat tcacctctgt ttccaagagt tctttgcagc aatgtcctat     2460

gtcttggagg atgagaaggg gagaggtaaa cattctaatt gcatcataga tttggaaaag     2520

acgctagaag catatggaat acatggcctg tttggggcat caaccacacg tttcctattg     2580

ggcctgttaa gtgatgaggg ggagagagag atggagaaca tctttcactg ccggctgtct     2640

caggggagga acctgatgca gtgggtcccg tccctgcagc tgctgctgca gccacactct     2700

ctggagtccc tccactgctt gtacgagact cggaacaaaa cgttcctgac acaagtgatg     2760

gcccatttcg aagaaatggg catgtgtgta gaaacagaca tggagctctt agtgtgcact     2820

ttctgcatta aattcagccg ccacgtgaag aagcttcagc tgattgaggg caggcagcac     2880

agatcaacat ggagccccac catggtagtc ctgttcaggt gggtcccagt cacagatgcc     2940

tattggcaga ttctcttctc cgtcctcaag gtcaccagaa acctgaagga gctggaccta     3000

agtggaaact cgctgagcca ctctgcagtg aagagtcttt gtaagaccct gagacgccct     3060

cgctgcctcc tggagaccct gcggttggct ggctgtggcc tcacagctga ggactgcaag     3120

gaccttgcct ttgggctgag agccaaccag accctgaccg agctggacct gagcttcaat     3180

gtgctcacgg atgctggagc caaacacctt tgccagagac tgagacagcc gagctgcaag     3240

ctacagcgac tgcagctggt cagctgtggc ctcacgtctg actgctgcca ggacctggcc     3300

tctgtgctta gtgccagccc cagcctgaag gagctagacc tgcagcagaa caacctggat     3360

gacgttggcg tgcgactgct ctgtgagggg ctcaggcatc ctgcctgcaa actcatacgc     3420

ctggggctgg accagacaac tctgagtgat gagatgaggc aggaactgag ggccctggag     3480

caggagaaac ctcagctgct catcttcagc agacggaaac caagtgtgat gacccctact     3540

gagggcctgg atacgggaga gatgagtaat agcacatcct cactcaagcg gcagagactc     3600

ggatcagaga gggcggcttc ccatgttgct caggctaatc tcaaactcct ggacgtgagc     3660

aagatcttcc caattgctga gattgcagag gaaagctccc cagaggtagt accggtggaa     3720

ctcttgtgcg tgccttctcc tgcctctcaa ggggacctgc atacgaagcc tttggggact     3780

gacgatgact tctggggccc cacggggcct gtggctactg aggtagttga caaagaaaag     3840

aacttgtacc gagttcactt ccctgtagct ggctcctacc gctggcccaa cacgggtctc     3900

tgctttgtga tgagagaagc ggtgaccgtt gagattgaat tctgtgtgtg ggaccagttc     3960

ctgggtgaga tcaacccaca gcacagctgg atggtggcag ggcctctgct ggacatcaag     4020

gctgagcctg gagctgtgga agctgtgcac ctccctcact ttgtggctct ccaagggggc     4080

catgtggaca catccctgtt ccaaatggcc cactttaaag aggaggggat gctcctggag     4140

aagccagcca gggtggagct gcatcacata gttctggaaa accccagctt ctcccccttg     4200

ggagtcctcc tgaaaatgat ccataatgcc ctgcgcttca ttcccgtcac ctctgtggtg     4260

ttgctttacc accgcgtcca tcctgaggaa gtcaccttcc acctctacct gatcccaagt     4320

gactgctcca ttcggaaggc catagatgat ctagaaatga aattccagtt tgtgcgaatc     4380

cacaagccac ccccgctgac cccactttat atgggctgtc gttacactgt gtctgggtct     4440

ggttcaggga tgctggaaat actccccaag gaactggagc tctgctatcg aagccctgga     4500

gaagaccagc tgttctcgga gttctacgtt ggccacttgg gatcagggat caggctgcaa     4560

gtgaaagaca agaaagatga gactctggtg tgggaggcct tggtgaaacc aggagatctc     4620

atgcctgcaa ctactctgat ccctccagcc cgcatagccg taccttcacc tctggatgcc     4680

ccgcagttgc tgcactttgt ggaccagtat cgagagcagc tgatagcccg agtgacatcg     4740

gtggaggttg tcttggacaa actgcatgga caggtgctga gccaggagca gtacgagagg     4800

gtgctggctg agaacacgag gcccagccag atgcggaagc tgttcagctt gagccagtcc     4860

tgggaccgga agtgcaaaga tggactctac caagccctga aggagaccca tcctcacctc     4920

attatggaac tctgggagaa gggcagcaaa aagggactcc tgccactcag cagctgaagt     4980

atcaacacca gcccttgacc cttgagtcct ggctttggct gacccttctt tgggtctcag     5040

tttctttctc tgcaaacaag ttgccatctg gtttgccttc cagcactaaa gtaatggaac     5100

tttgatgatg cctttgctgg gcattatgtg tccatgccag ggatgccaca gggggcccca     5160

gtccaggtgg cctaacagca tctcagggaa tgtccatctg gagctggcaa gacccctgca     5220

gacctcatag agcctcatct ggtggccaca gcagccaagc ctagagccct ccggatccca     5280

tccaggcgca aagaggaata ggagggacat ggaaccattt gcctctggct gtgtcacagg     5340

gtgagcccca aaattggggt tcagcgtggg aggccacgtg gattcttggc tttgtacagg     5400

aagatctaca agagcaagcc aacagagtaa agtggaagga agtttattca gaaaataaag     5460

gagtatcaca gctcttttag aatttgtcta gcaggctttc cagtttttac cagaaaaccc     5520

ctataaatta aaaatttttt acttaaattt aagaattaaa aaaatacaaa aaagaaaaaa     5580

tgaaaataaa ggaataagaa gttacctact ccaaaaaaaa aaa                       5623


<210>  13
<211>  5533
<212>  DNA
<213>  homo sapiens

<400>  13
cttgttgact aggcgctgtt cttgctggct ggtgccccag ggcctggaga ggtctgaaga       60

aacctgggag ccagcagccc ggggctccac tctgggttct gaaagcccat tccctgctct      120

gcggctcctc ccaccccacc tcttctcagc cttgcagctc aagggttgat ctcaggagtc      180

caggacccag gagagggaag aatctgagga acacagaaca gtgagcgttg cccacacccc      240

atctcccgtc accacatctc ccctcaccct caccctccct gcctggccct ggaccccatc      300

ccaggacctc cctatcagct gacttcttcc agtgtcttgc aggcccctct gggctcctcc      360

ctcccctggc ttttcctacc actccccctc tatcggcgtc tatctgtagg tgccctggga      420

tttataaaac tgggttccga atgctgaata agagacggta agagccaagg caaaggacag      480

cactgttctc tgcctgcctg ataccctcac cacctgggaa catcccccag acaccctctt      540

aactccggga cagagatggc tggcggagcc tggggccgcc tggcctgtta cttggagttc      600

ctgaagaagg aggagctgaa ggagttccag cttctgctcg ccaataaagc gcactccagg      660

agctcttcgg gtgagacacc cgctcagcca gagaagacga gtggcatgga ggtggcctcg      720

tacctggtgg ctcagtatgg ggagcagcgg gcctgggacc tagccctcca tacctgggag      780

cagatggggc tgaggtcact gtgcgcccaa gcccaggaag gggcaggcca ctctccctca      840

ttcccctaca gcccaagtga accccacctg gggtctccca gccaacccac ctccaccgca      900

gtgctaatgc cctggatcca tgaattgccg gcggggtgca cccagggctc agagagaagg      960

gttttgagac agctgcctga cacatctgga cgccgctgga gagaaatctc tgcctcactc     1020

ctctaccaag ctcttccaag ctccccagac catgagtctc caagccagga gtcacccaac     1080

gcccccacat ccacagcagt gctggggagc tggggatccc cacctcagcc cagcctagca     1140

cccagagagc aggaggctcc tgggacccaa tggcctctgg atgaaacgtc aggaatttac     1200

tacacagaaa tcagagaaag agagagagag aaatcagaga aaggcaggcc cccatgggca     1260

gcggtggtag gaacgccccc acaggcgcac accagcctac agccccacca ccacccatgg     1320

gagccttctg tgagagagag cctctgttcc acatggccct ggaaaaatga ggattttaac     1380

caaaaattca cacagctgct acttctacaa agacctcacc ccagaagcca agatcccctg     1440

gtcaagagaa gctggcctga ttatgtggag gagaatcgag gacatttaat tgagatcaga     1500

gacttatttg gcccaggcct ggatacccaa gaacctcgca tagtcatact gcagggggct     1560

gctggaattg ggaagtcaac actggccagg caggtgaagg aagcctgggg gagaggccag     1620

ctgtatgggg accgcttcca gcatgtcttc tacttcagct gcagagagct ggcccagtcc     1680

aaggtggtga gtctcgctga gctcatcgga aaagatggga cagccactcc ggctcccatt     1740

agacagatcc tgtctaggcc agagcggctg ctcttcatcc tcgatggtgt agatgagcca     1800

ggatgggtct tgcaggagcc gagttctgag ctctgtctgc actggagcca gccacagccg     1860

gcggatgcac tgctgggcag tttgctgggg aaaactatac ttcccgaggc atccttcctg     1920

atcacggctc ggaccacagc tctgcagaac ctcattcctt ctttggagca ggcacgttgg     1980

gtagaggtcc tggggttctc tgagtccagc aggaaggaat atttctacag atatttcaca     2040

gatgaaaggc aagcaattag agcctttagg ttggtcaaat caaacaaaga gctctgggcc     2100

ctgtgtcttg tgccctgggt gtcctggctg gcctgcactt gcctgatgca gcagatgaag     2160

cggaaggaaa aactcacact gacttccaag accaccacaa ccctctgtct acattacctt     2220

gcccaggctc tccaagctca gccattggga ccccagctca gagacctctg ctctctggct     2280

gctgagggca tctggcaaaa aaagaccctt ttcagtccag atgacctcag gaagcatggg     2340

ttagatgggg ccatcatctc caccttcttg aagatgggta ttcttcaaga gcaccccatc     2400

cctctgagct acagcttcat tcacctctgt ttccaagagt tctttgcagc aatgtcctat     2460

gtcttggagg atgagaaggg gagaggtaaa cattctaatt gcatcataga tttggaaaag     2520

acgctagaag catatggaat acatggcctg tttggggcat caaccacacg tttcctattg     2580

ggcctgttaa gtgatgaggg ggagagagag atggagaaca tctttcactg ccggctgtct     2640

caggggagga acctgatgca gtgggtcccg tccctgcagc tgctgctgca gccacactct     2700

ctggagtccc tccactgctt gtacgagact cggaacaaaa cgttcctgac acaagtgatg     2760

gcccatttcg aagaaatggg catgtgtgta gaaacagaca tggagctctt agtgtgcact     2820

ttctgcatta aattcagccg ccacgtgaag aagcttcagc tgattgaggg caggcagcac     2880

agatcaacat ggagccccac catggtagtc ctgttcaggt gggtcccagt cacagatgcc     2940

tattggcaga ttctcttctc cgtcctcaag gtcaccagaa acctgaagga gctggaccta     3000

agtggaaact cgctgagcca ctctgcagtg aagagtcttt gtaagaccct gagacgccct     3060

cgctgcctcc tggagaccct gcggttggct ggctgtggcc tcacagctga ggactgcaag     3120

gaccttgcct ttgggctgag agccaaccag accctgaccg agctggacct gagcttcaat     3180

gtgctcacgg atgctggagc caaacacctt tgccagagac tgagacagcc gagctgcaag     3240

ctacagcgac tgcagctggt cagctgtggc ctcacgtctg actgctgcca ggacctggcc     3300

tctgtgctta gtgccagccc cagcctgaag gagctagacc tgcagcagaa caacctggat     3360

gacgttggcg tgcgactgct ctgtgagggg ctcaggcatc ctgcctgcaa actcatacgc     3420

ctggggaaac caagtgtgat gacccctact gagggcctgg atacgggaga gatgagtaat     3480

agcacatcct cactcaagcg gcagagactc ggatcagaga gggcggcttc ccatgttgct     3540

caggctaatc tcaaactcct ggacgtgagc aagatcttcc caattgctga gattgcagag     3600

gaaagctccc cagaggtagt accggtggaa ctcttgtgcg tgccttctcc tgcctctcaa     3660

ggggacctgc atacgaagcc tttggggact gacgatgact tctggggccc cacggggcct     3720

gtggctactg aggtagttga caaagaaaag aacttgtacc gagttcactt ccctgtagct     3780

ggctcctacc gctggcccaa cacgggtctc tgctttgtga tgagagaagc ggtgaccgtt     3840

gagattgaat tctgtgtgtg ggaccagttc ctgggtgaga tcaacccaca gcacagctgg     3900

atggtggcag ggcctctgct ggacatcaag gctgagcctg gagctgtgga agctgtgcac     3960

ctccctcact ttgtggctct ccaagggggc catgtggaca catccctgtt ccaaatggcc     4020

cactttaaag aggaggggat gctcctggag aagccagcca gggtggagct gcatcacata     4080

gttctggaaa accccagctt ctcccccttg ggagtcctcc tgaaaatgat ccataatgcc     4140

ctgcgcttca ttcccgtcac ctctgtggtg ttgctttacc accgcgtcca tcctgaggaa     4200

gtcaccttcc acctctacct gatcccaagt gactgctcca ttcggaaggc catagatgat     4260

ctagaaatga aattccagtt tgtgcgaatc cacaagccac ccccgctgac cccactttat     4320

atgggctgtc gttacactgt gtctgggtct ggttcaggga tgctggaaat actccccaag     4380

gaactggagc tctgctatcg aagccctgga gaagaccagc tgttctcgga gttctacgtt     4440

ggccacttgg gatcagggat caggctgcaa gtgaaagaca agaaagatga gactctggtg     4500

tgggaggcct tggtgaaacc aggagatctc atgcctgcaa ctactctgat ccctccagcc     4560

cgcatagccg taccttcacc tctggatgcc ccgcagttgc tgcactttgt ggaccagtat     4620

cgagagcagc tgatagcccg agtgacatcg gtggaggttg tcttggacaa actgcatgga     4680

caggtgctga gccaggagca gtacgagagg gtgctggctg agaacacgag gcccagccag     4740

atgcggaagc tgttcagctt gagccagtcc tgggaccgga agtgcaaaga tggactctac     4800

caagccctga aggagaccca tcctcacctc attatggaac tctgggagaa gggcagcaaa     4860

aagggactcc tgccactcag cagctgaagt atcaacacca gcccttgacc cttgagtcct     4920

ggctttggct gacccttctt tgggtctcag tttctttctc tgcaaacaag ttgccatctg     4980

gtttgccttc cagcactaaa gtaatggaac tttgatgatg cctttgctgg gcattatgtg     5040

tccatgccag ggatgccaca gggggcccca gtccaggtgg cctaacagca tctcagggaa     5100

tgtccatctg gagctggcaa gacccctgca gacctcatag agcctcatct ggtggccaca     5160

gcagccaagc ctagagccct ccggatccca tccaggcgca aagaggaata ggagggacat     5220

ggaaccattt gcctctggct gtgtcacagg gtgagcccca aaattggggt tcagcgtggg     5280

aggccacgtg gattcttggc tttgtacagg aagatctaca agagcaagcc aacagagtaa     5340

agtggaagga agtttattca gaaaataaag gagtatcaca gctcttttag aatttgtcta     5400

gcaggctttc cagtttttac cagaaaaccc ctataaatta aaaatttttt acttaaattt     5460

aagaattaaa aaaatacaaa aaagaaaaaa tgaaaataaa ggaataagaa gttacctact     5520

ccaaaaaaaa aaa                                                        5533


<210>  14
<211>  5401
<212>  DNA
<213>  homo sapiens

<400>  14
cttgttgact aggcgctgtt cttgctggct ggtgccccag ggcctggaga ggtctgaaga       60

aacctgggag ccagcagccc ggggctccac tctgggttct gaaagcccat tccctgctct      120

gcggctcctc ccaccccacc tcttctcagc cttgcagctc aagggttgat ctcaggagtc      180

caggacccag gagagggaag aatctgagga acacagaaca gtgagcgttg cccacacccc      240

atctcccgtc accacatctc ccctcaccct caccctccct gcctggccct ggaccccatc      300

ccaggacctc cctatcagct gacttcttcc agtgtcttgc aggcccctct gggctcctcc      360

ctcccctggc ttttcctacc actccccctc tatcggcgtc tatctgtagg tgccctggga      420

tttataaaac tgggttccga atgctgaata agagacggta agagccaagg caaaggacag      480

cactgttctc tgcctgcctg ataccctcac cacctgggaa catcccccag acaccctctt      540

aactccggga cagagatggc tggcggagcc tggggccgcc tggcctgtta cttggagttc      600

ctgaagaagg aggagctgaa ggagttccag cttctgctcg ccaataaagc gcactccagg      660

agctcttcgg gtgagacacc cgctcagcca gagaagacga gtggcatgga ggtggcctcg      720

tacctggtgg ctcagtatgg ggagcagcgg gcctgggacc tagccctcca tacctgggag      780

cagatggggc tgaggtcact gtgcgcccaa gcccaggaag gggcaggcca ctctccctca      840

ttcccctaca gcccaagtga accccacctg gggtctccca gccaacccac ctccaccgca      900

gtgctaatgc cctggatcca tgaattgccg gcggggtgca cccagggctc agagagaagg      960

gttttgagac agctgcctga cacatctgga cgccgctgga gagaaatctc tgcctcactc     1020

ctctaccaag ctcttccaag ctccccagac catgagtctc caagccagga gtcacccaac     1080

gcccccacat ccacagcagt gctggggagc tggggatccc cacctcagcc cagcctagca     1140

cccagagagc aggaggctcc tgggacccaa tggcctctgg atgaaacgtc aggaatttac     1200

tacacagaaa tcagagaaag agagagagag aaatcagaga aaggcaggcc cccatgggca     1260

gcggtggtag gaacgccccc acaggcgcac accagcctac agccccacca ccacccatgg     1320

gagccttctg tgagagagag cctctgttcc acatggccct ggaaaaatga ggattttaac     1380

caaaaattca cacagctgct acttctacaa agacctcacc ccagaagcca agatcccctg     1440

gtcaagagaa gctggcctga ttatgtggag gagaatcgag gacatttaat tgagatcaga     1500

gacttatttg gcccaggcct ggatacccaa gaacctcgca tagtcatact gcagggggct     1560

gctggaattg ggaagtcaac actggccagg caggtgaagg aagcctgggg gagaggccag     1620

ctgtatgggg accgcttcca gcatgtcttc tacttcagct gcagagagct ggcccagtcc     1680

aaggtggtga gtctcgctga gctcatcgga aaagatggga cagccactcc ggctcccatt     1740

agacagatcc tgtctaggcc agagcggctg ctcttcatcc tcgatggtgt agatgagcca     1800

ggatgggtct tgcaggagcc gagttctgag ctctgtctgc actggagcca gccacagccg     1860

gcggatgcac tgctgggcag tttgctgggg aaaactatac ttcccgaggc atccttcctg     1920

atcacggctc ggaccacagc tctgcagaac ctcattcctt ctttggagca ggcacgttgg     1980

gtagaggtcc tggggttctc tgagtccagc aggaaggaat atttctacag atatttcaca     2040

gatgaaaggc aagcaattag agcctttagg ttggtcaaat caaacaaaga gctctgggcc     2100

ctgtgtcttg tgccctgggt gtcctggctg gcctgcactt gcctgatgca gcagatgaag     2160

cggaaggaaa aactcacact gacttccaag accaccacaa ccctctgtct acattacctt     2220

gcccaggctc tccaagctca gccattggga ccccagctca gagacctctg ctctctggct     2280

gctgagggca tctggcaaaa aaagaccctt ttcagtccag atgacctcag gaagcatggg     2340

ttagatgggg ccatcatctc caccttcttg aagatgggta ttcttcaaga gcaccccatc     2400

cctctgagct acagcttcat tcacctctgt ttccaagagt tctttgcagc aatgtcctat     2460

gtcttggagg atgagaaggg gagaggtaaa cattctaatt gcatcataga tttggaaaag     2520

acgctagaag catatggaat acatggcctg tttggggcat caaccacacg tttcctattg     2580

ggcctgttaa gtgatgaggg ggagagagag atggagaaca tctttcactg ccggctgtct     2640

caggggagga acctgatgca gtgggtcccg tccctgcagc tgctgctgca gccacactct     2700

ctggagtccc tccactgctt gtacgagact cggaacaaaa cgttcctgac acaagtgatg     2760

gcccatttcg aagaaatggg catgtgtgta gaaacagaca tggagctctt agtgtgcact     2820

ttctgcatta aattcagccg ccacgtgaag aagcttcagc tgattgaggg caggcagcac     2880

agatcaacat ggagccccac catggtagtc ctgttcaggt gggtcccagt cacagatgcc     2940

tattggcaga ttctcttctc cgtcctcaag gtcaccagaa acctgaagga gctggaccta     3000

agtggaaact cgctgagcca ctctgcagtg aagagtcttt gtaagaccct gagacgccct     3060

cgctgcctcc tggagaccct gcggttggct ggctgtggcc tcacagctga ggactgcaag     3120

gaccttgcct ttgggctgag agccaaccag accctgaccg agctggacct gagcttcaat     3180

gtgctcacgg atgctggagc caaacacctt tgccagagac tgagacagcc gagctgcaag     3240

ctacagcgac tgcagctggt cagctgtggc ctcacgtctg actgctgcca ggacctggcc     3300

tctgtgctta gtgccagccc cagcctgaag gagctagacc tgcagcagaa caacctggat     3360

gacgttggcg tgcgactgct ctgtgagggg ctcaggcatc ctgcctgcaa actcatacgc     3420

ctggggaaac caagtgtgat gacccctact gagggcctgg atacgggaga gatgagtaat     3480

agcacatcct cactcaagcg gcagagactc ggatcagaga gggcggcttc ccatgttgct     3540

caggctaatc tcaaactcct ggacgtgagc aagatcttcc caattgctga gattgcagag     3600

gaaagctccc cagaggtagt accggtggaa ctcttgtgcg tgccttctcc tgcctctcaa     3660

ggggacctgc atacgaagcc tttggggact gacgatgact tctggggccc cacggggcct     3720

gtggctactg aggtagttga caaagaaaag aacttgtacc gagttcactt ccctgtagct     3780

ggctcctacc gctggcccaa cacgggtctc tgctttgtga tgagagaagc ggtgaccgtt     3840

gagattgaat tctgtgtgtg ggaccagttc ctgggtgaga tcaacccaca gcacagctgg     3900

atggtggcag ggcctctgct ggacatcaag gctgagcctg gagctgtgga agctgtgcac     3960

ctccctcact ttgtggctct ccaagggggc catgtggaca catccctgtt ccaaatggcc     4020

cactttaaag aggaggggat gctcctggag aagccagcca gggtggagct gcatcacata     4080

gttctggaaa accccagctt ctcccccttg ggagtcctcc tgaaaatgat ccataatgcc     4140

ctgcgcttca ttcccgtcac ctctgtggtg ttgctttacc accgcgtcca tcctgaggaa     4200

gtcaccttcc acctctacct gatcccaagt gactgctcca ttcggaagga actggagctc     4260

tgctatcgaa gccctggaga agaccagctg ttctcggagt tctacgttgg ccacttggga     4320

tcagggatca ggctgcaagt gaaagacaag aaagatgaga ctctggtgtg ggaggccttg     4380

gtgaaaccag gagatctcat gcctgcaact actctgatcc ctccagcccg catagccgta     4440

ccttcacctc tggatgcccc gcagttgctg cactttgtgg accagtatcg agagcagctg     4500

atagcccgag tgacatcggt ggaggttgtc ttggacaaac tgcatggaca ggtgctgagc     4560

caggagcagt acgagagggt gctggctgag aacacgaggc ccagccagat gcggaagctg     4620

ttcagcttga gccagtcctg ggaccggaag tgcaaagatg gactctacca agccctgaag     4680

gagacccatc ctcacctcat tatggaactc tgggagaagg gcagcaaaaa gggactcctg     4740

ccactcagca gctgaagtat caacaccagc ccttgaccct tgagtcctgg ctttggctga     4800

cccttctttg ggtctcagtt tctttctctg caaacaagtt gccatctggt ttgccttcca     4860

gcactaaagt aatggaactt tgatgatgcc tttgctgggc attatgtgtc catgccaggg     4920

atgccacagg gggccccagt ccaggtggcc taacagcatc tcagggaatg tccatctgga     4980

gctggcaaga cccctgcaga cctcatagag cctcatctgg tggccacagc agccaagcct     5040

agagccctcc ggatcccatc caggcgcaaa gaggaatagg agggacatgg aaccatttgc     5100

ctctggctgt gtcacagggt gagccccaaa attggggttc agcgtgggag gccacgtgga     5160

ttcttggctt tgtacaggaa gatctacaag agcaagccaa cagagtaaag tggaaggaag     5220

tttattcaga aaataaagga gtatcacagc tcttttagaa tttgtctagc aggctttcca     5280

gtttttacca gaaaacccct ataaattaaa aattttttac ttaaatttaa gaattaaaaa     5340

aatacaaaaa agaaaaaatg aaaataaagg aataagaagt tacctactcc aaaaaaaaaa     5400

a                                                                     5401


<210>  15
<211>  3538
<212>  DNA
<213>  homo sapiens

<400>  15
ggcaagacaa cgaggatttg cgtagggggc gagcctctga ggccacttgg ctcttacggc       60

cacgcagggc gccgcagatg cagccggagc ccgcttttcc ctctcaggac gacccctagg      120

ccgccagcag ttccctaccg acgaaggcga ctgtacagcg tccaccgcgt tcgtgcccac      180

ttacccgccg ccccactccg ggccgccggc tcgcagcagg accagcccgg ctgctacggc      240

cgcggataca cgccctcagg cccggcgctg cgcagcttgc ggaagctttc ccggacagac      300

tcgctgccag cggattggct gcgagcagcg ccaatctcac gttgcccccg ggcgaggcgg      360

gactcagtgc cgcgctctct gcacccgctc tgccgcgcgc gtgcgtgctg ggtgcgggtg      420

cgggtgcggg gttgggcctg cgcatcgggt gagacgctgg ctgcttgcgg ctagtggatg      480

gtaattgcct gcctcgcgct agcaggaagc tgctctgtta aaagcgaaaa tgaaacaatt      540

gcctgcggca acagttcgac tcctttcaag ttctcagatc atcacttcgg tggtcagtgt      600

tgtaaaagag cttattgaaa actccttgga tgctggtgcc acaagcgtag atgttaaact      660

ggagaactat ggatttgata aaattgaggt gcgagataac ggggagggta tcaaggctgt      720

tgatgcacct gtaatggcaa tgaagtacta cacctcaaaa ataaatagtc atgaagatct      780

tgaaaatttg acaacttacg gttttcgtgg agaagccttg gggtcaattt gttgtatagc      840

tgaggtttta attacaacaa gaacggctgc tgataatttt agcacccagt atgttttaga      900

tggcagtggc cacatacttt ctcagaaacc ttcacatctt ggtcaaggta caactgtaac      960

tgctttaaga ttatttaaga atctacctgt aagaaagcag ttttactcaa ctgcaaaaaa     1020

atgtaaagat gaaataaaaa agatccaaga tctcctcatg agctttggta tccttaaacc     1080

tgacttaagg attgtctttg tacataacaa ggcagttatt tggcagaaaa gcagagtatc     1140

agatcacaag atggctctca tgtcagttct ggggactgct gttatgaaca atatggaatc     1200

ctttcagtac cactctgaag aatctcagat ttatctcagt ggatttcttc caaagtgtga     1260

tgcagaccac tctttcacta gtctttcaac accagaaaga agtttcatct tcataaacag     1320

tcgaccagta catcaaaaag atatcttaaa gttaatccga catcattaca atctgaaatg     1380

cctaaaggaa tctactcgtt tgtatcctgt tttctttctg aaaatcgatg ttcctacagc     1440

tgatgttgat gtaaatttaa caccagataa aagccaagta ttattacaaa ataaggaatc     1500

tgttttaatt gctcttgaaa atctgatgac gacttgttat ggaccattac ctagtacaaa     1560

ttcttatgaa aataataaaa cagatgtttc cgcagctgac atcgttctta gtaaaacagc     1620

agaaacagat gtgcttttta ataaagtgga atcatctgga aagaattatt caaatgttga     1680

tacttcagtc attccattcc aaaatgatat gcataatgat gaatctggaa aaaacactga     1740

tgattgttta aatcaccaga taagtattgg tgactttggt tatggtcatt gtagtagtga     1800

aatttctaac attgataaaa acactaagaa tgcatttcag gacatttcaa tgagtaatgt     1860

atcatgggag aactctcaga cggaatatag taaaacttgt tttataagtt ccgttaagca     1920

cacccagtca gaaaatggca ataaagacca tatagatgag agtggggaaa atgaggaaga     1980

agcaggtctt gaaaactctt cggaaatttc tgcagatgag tggagcaggg gaaatatact     2040

taaaaattca gtgggagaga atattgaacc tgtgaaaatt ttagtgcctg aaaaaagttt     2100

accatgtaaa gtaagtaata ataattatcc aatccctgaa caaatgaatc ttaatgaaga     2160

ttcatgtaac aaaaaatcaa atgtaataga taataaatct ggaaaagtta cagcttatga     2220

tttacttagc aatcgagtaa tcaagaaacc catgtcagca agtgctcttt ttgttcaaga     2280

tcatcgtcct cagtttctca tagaaaatcc taagactagt ttagaggatg caacactaca     2340

aattgaagaa ctgtggaaga cattgagtga agaggaaaaa ctgaaatatg aagagaaggc     2400

tactaaagac ttggaacgat acaatagtca aatgaagaga gccattgaac aggagtcaca     2460

aatgtcacta aaagatggca gaaaaaagat aaaacccacc agcgcatgga atttggccca     2520

gaagcacaag ttaaaaacct cattatctaa tcaaccaaaa cttgatgaac tccttcagtc     2580

ccaaattgaa aaaagaagga gtcaaaatat taaaatggta cagatcccct tttctatgaa     2640

aaacttaaaa ataaatttta agaaacaaaa caaagttgac ttagaagaga aggatgaacc     2700

ttgcttgatc cacaatctca ggtttcctga tgcatggcta atgacatcca aaacagaggt     2760

aatgttatta aatccatata gagtagaaga agccctgcta tttaaaagac ttcttgagaa     2820

tcataaactt cctgcagagc cactggaaaa gccaattatg ttaacagaga gtctttttaa     2880

tggatctcat tatttagacg ttttatataa aatgacagca gatgaccaaa gatacagtgg     2940

atcaacttac ctgtctgatc ctcgtcttac agcgaatggt ttcaagataa aattgatacc     3000

aggagtttca attactgaaa attacttgga aatagaagga atggctaatt gtctcccatt     3060

ctatggagta gcagatttaa aagaaattct taatgctata ttaaacagaa atgcaaagga     3120

agtttatgaa tgtagacctc gcaaagtgat aagttattta gagggagaag cagtgcgtct     3180

atccagacaa ttacccatgt acttatcaaa agaggacatc caagacatta tctacagaat     3240

gaagcaccag tttggaaatg aaattaaaga gtgtgttcat ggtcgcccat tttttcatca     3300

tttaacctat cttccagaaa ctacatgatt aaatatgttt aagaagatta gttaccattg     3360

aaattggttc tgtcataaaa cagcatgagt ctggttttaa attatctttg tattatgtgt     3420

cacatggtta ttttttaaat gaggattcac tgacttgttt ttatattgaa aaaagttcca     3480

cgtattgtag aaaacgtaaa taaactaata tagactattc aaaaaaaaaa aaaaaaaa       3538


<210>  16
<211>  3421
<212>  DNA
<213>  homo sapiens

<400>  16
ggcaagacaa cgaggatttg cgtagggggc gagcctctga ggccacttgg ctcttacggc       60

cacgcagggc gccgcagatg cagccggagc ccgcttttcc ctctcaggac gacccctagg      120

ccgccagcag ttccctaccg acgaaggcga ctgtacagcg tccaccgcgt tcgtgcccac      180

ttacccgccg ccccactccg ggccgccggc tcgcagcagg accagcccgg ctgctacggc      240

cgcggataca cgccctcagg cccggcgctg cgcagcttgc ggaagctttc ccggacagac      300

tcgctgccag cggattggct gcgagcagcg ccaatctcac gttgcccccg ggcgaggcgg      360

gactcagtgc cgcgctctct gcacccgctc tgccgcgcgc gtgcgtgctg ggtgcgggtg      420

cgggtgcggg gttgggcctg cgcatcgggt gagacgctgg ctgcttgcgg ctagtggatg      480

gtaattgcct gcctcgcgct agcaggaagc tgctctgtta aaagcgaaaa tgaaacaatt      540

gcctgcggca acagttcgac tcctttcaag ttctcagatc atcacttcgg tggtcagtgt      600

tgtaaaagag cttattgaaa actccttgga tgctggtgcc acaagcgtag atgttaaact      660

ggagaactat ggatttgata aaattgaggt gcgagataac ggggagggta tcaaggctgt      720

tgatgcacct gtaatggcaa tgaagtacta cacctcaaaa ataaatagtc atgaagatct      780

tgaaaatttg acaacttacg gttttcgtgg agaagccttg gggtcaattt gttgtatagc      840

tgaggtttta attacaacaa gaacggctgc tgataatttt agcacccagt atgttttaga      900

tggcagtggc cacatacttt ctcagaaacc ttcacatctt ggtcaaggta caactgtaac      960

tgctttaaga ttatttaaga atctacctgt aagaaagcag ttttactcaa ctgcaaaaaa     1020

atgtaaagat gaaataaaaa agatccaaga tctcctcatg agctttggta tccttaaacc     1080

tgacttaagg attgtctttg tacataacaa gatttatctc agtggatttc ttccaaagtg     1140

tgatgcagac cactctttca ctagtctttc aacaccagaa agaagtttca tcttcataaa     1200

cagtcgacca gtacatcaaa aagatatctt aaagttaatc cgacatcatt acaatctgaa     1260

atgcctaaag gaatctactc gtttgtatcc tgttttcttt ctgaaaatcg atgttcctac     1320

agctgatgtt gatgtaaatt taacaccaga taaaagccaa gtattattac aaaataagga     1380

atctgtttta attgctcttg aaaatctgat gacgacttgt tatggaccat tacctagtac     1440

aaattcttat gaaaataata aaacagatgt ttccgcagct gacatcgttc ttagtaaaac     1500

agcagaaaca gatgtgcttt ttaataaagt ggaatcatct ggaaagaatt attcaaatgt     1560

tgatacttca gtcattccat tccaaaatga tatgcataat gatgaatctg gaaaaaacac     1620

tgatgattgt ttaaatcacc agataagtat tggtgacttt ggttatggtc attgtagtag     1680

tgaaatttct aacattgata aaaacactaa gaatgcattt caggacattt caatgagtaa     1740

tgtatcatgg gagaactctc agacggaata tagtaaaact tgttttataa gttccgttaa     1800

gcacacccag tcagaaaatg gcaataaaga ccatatagat gagagtgggg aaaatgagga     1860

agaagcaggt cttgaaaact cttcggaaat ttctgcagat gagtggagca ggggaaatat     1920

acttaaaaat tcagtgggag agaatattga acctgtgaaa attttagtgc ctgaaaaaag     1980

tttaccatgt aaagtaagta ataataatta tccaatccct gaacaaatga atcttaatga     2040

agattcatgt aacaaaaaat caaatgtaat agataataaa tctggaaaag ttacagctta     2100

tgatttactt agcaatcgag taatcaagaa acccatgtca gcaagtgctc tttttgttca     2160

agatcatcgt cctcagtttc tcatagaaaa tcctaagact agtttagagg atgcaacact     2220

acaaattgaa gaactgtgga agacattgag tgaagaggaa aaactgaaat atgaagagaa     2280

ggctactaaa gacttggaac gatacaatag tcaaatgaag agagccattg aacaggagtc     2340

acaaatgtca ctaaaagatg gcagaaaaaa gataaaaccc accagcgcat ggaatttggc     2400

ccagaagcac aagttaaaaa cctcattatc taatcaacca aaacttgatg aactccttca     2460

gtcccaaatt gaaaaaagaa ggagtcaaaa tattaaaatg gtacagatcc ccttttctat     2520

gaaaaactta aaaataaatt ttaagaaaca aaacaaagtt gacttagaag agaaggatga     2580

accttgcttg atccacaatc tcaggtttcc tgatgcatgg ctaatgacat ccaaaacaga     2640

ggtaatgtta ttaaatccat atagagtaga agaagccctg ctatttaaaa gacttcttga     2700

gaatcataaa cttcctgcag agccactgga aaagccaatt atgttaacag agagtctttt     2760

taatggatct cattatttag acgttttata taaaatgaca gcagatgacc aaagatacag     2820

tggatcaact tacctgtctg atcctcgtct tacagcgaat ggtttcaaga taaaattgat     2880

accaggagtt tcaattactg aaaattactt ggaaatagaa ggaatggcta attgtctccc     2940

attctatgga gtagcagatt taaaagaaat tcttaatgct atattaaaca gaaatgcaaa     3000

ggaagtttat gaatgtagac ctcgcaaagt gataagttat ttagagggag aagcagtgcg     3060

tctatccaga caattaccca tgtacttatc aaaagaggac atccaagaca ttatctacag     3120

aatgaagcac cagtttggaa atgaaattaa agagtgtgtt catggtcgcc cattttttca     3180

tcatttaacc tatcttccag aaactacatg attaaatatg tttaagaaga ttagttacca     3240

ttgaaattgg ttctgtcata aaacagcatg agtctggttt taaattatct ttgtattatg     3300

tgtcacatgg ttatttttta aatgaggatt cactgacttg tttttatatt gaaaaaagtt     3360

ccacgtattg tagaaaacgt aaataaacta atatagacta ttcaaaaaaa aaaaaaaaaa     3420

a                                                                     3421


<210>  17
<211>  3052
<212>  DNA
<213>  homo sapiens

<400>  17
ggcaagacaa cgaggatttg cgtagggggc gagcctctga ggccacttgg ctcttacggc       60

cacgcagggc gccgcagatg cagccggagc ccgcttttcc ctctcaggac gacccctagg      120

ccgccagcag ttccctaccg acgaaggcga ctgtacagcg tccaccgcgt tcgtgcccac      180

ttacccgccg ccccactccg ggccgccggc tcgcagcagg accagcccgg ctgctacggc      240

cgcggataca cgccctcagg cccggcgctg cgcagcttgc ggaagctttc ccggacagac      300

tcgctgccag cggattggct gcgagcagcg ccaatctcac gttgcccccg ggcgaggcgg      360

gactcagtgc cgcgctctct gcacccgctc tgccgcgcgc gtgcgtgctg ggtgcgggtg      420

cgggtgcggg gttgggcctg cgcatcgggt gagacgctgg ctgcttgcgg ctagtggatg      480

gtaattgcct gcctcgcgct agcaggaagc tgctctgtta aaagcgaaaa tgaaacaatt      540

gcctgcggca acagttcgac tcctttcaag ttctcagatc atcacttcgg tggtcagtgt      600

tgtaaaagag cttattgaaa actccttgga tgctggtgcc acaagcgtag atgttaaact      660

ggagaactat ggatttgata aaattgaggt gcgagataac ggggagggta tcaaggctgt      720

tgatgcacct gtaatggcaa tgaagtacta cacctcaaaa ataaatagtc atgaagatct      780

tgaaaatttg acaacttacg gttttcgtgg agaagccttg gggtcaattt gttgtatagc      840

tgaggtttta attacaacaa gaacggctgc tgataatttt agcacccagt atgttttaga      900

tggcagtggc cacatacttt ctcagaaacc ttcacatctt ggtcaaggta caactgtaac      960

tgctttaaga ttatttaaga atctacctgt aagaaagcag ttttactcaa ctgcaaaaaa     1020

atgtaaagat gaaataaaaa agatccaaga tctcctcatg agctttggta tccttaaacc     1080

tgacttaagg attgtctttg tacataacaa ggcagttatt tggcagaaaa gcagagtatc     1140

agatcacaag atggctctca tgtcagttct ggggactgct gttatgaaca atatggaatc     1200

ctttcagtac cactctgaag aatctcagat ttatctcagt ggatttcttc caaagtgtga     1260

tgcagaccac tctttcacta gtctttcaac accagaaaga agtttcatct tcataaacag     1320

tcgaccagta catcaaaaag atatcttaaa gttaatccga catcattaca atctgaaatg     1380

cctaaaggaa tctactcgtt tgtatcctgt tttctttctg aaaatcgatg ttcctacagc     1440

tgatgttgat gtaaatttaa caccagataa aagccaagta ttattacaaa ataaggaatc     1500

tgttttaatt gctcttgaaa atctgatgac gacttgttat ggaccattac ctagtacaaa     1560

ttcttatgaa aataataaaa cagatgtttc cgcagctgac atcgttctta gtaaaacagc     1620

agaaacagat gtgcttttta ataaagtgga atcatctgga aagaattatt caaatgttga     1680

tacttcagtc attccattcc aaaatgatat gcataatgat gaatctggaa aaaacactga     1740

tgattgttta aatcaccaga taagtattgg tgactttggt tatggtcatt gtagtagtga     1800

aatttctaac attgataaaa acactaagaa tgcatttcag gacatttcaa tgagtaatgt     1860

atcatgggag aactctcaga cggaatatag taaaacttgt tttataagtt ccgttaagca     1920

cacccagtca gaaaatggca ataaagacca tatagatgag agtggggaaa atgaggaaga     1980

agcaggtctt gaaaactctt cggaaatttc tgcagatgag tggagcaggg gaaatatact     2040

taaaaattca gtgggagaga atattgaacc tgtgaaaatt ttagtgcctg aaaaaagttt     2100

accatgtaaa gtaagtaata ataattatcc aatccctgaa caaatgaatc ttaatgaaga     2160

ttcatgtaac aaaaaatcaa atgtaataga taataaatct ggaaaagtta cagcttatga     2220

tttacttagc aatcgagtaa tcaagaaacc catgtcagca agtgctcttt ttgttcaaga     2280

tcatcgtcct cagtttctca tagaaaatcc taagactagt ttagaggatg caacactaca     2340

aattgaagaa ctgtggaaga cattgagtga agaggaaaaa ctgaatcttt ttaatggatc     2400

tcattattta gacgttttat ataaaatgac agcagatgac caaagataca gtggatcaac     2460

ttacctgtct gatcctcgtc ttacagcgaa tggtttcaag ataaaattga taccaggagt     2520

ttcaattact gaaaattact tggaaataga aggaatggct aattgtctcc cattctatgg     2580

agtagcagat ttaaaagaaa ttcttaatgc tatattaaac agaaatgcaa aggaagttta     2640

tgaatgtaga cctcgcaaag tgataagtta tttagaggga gaagcagtgc gtctatccag     2700

acaattaccc atgtacttat caaaagagga catccaagac attatctaca gaatgaagca     2760

ccagtttgga aatgaaatta aagagtgtgt tcatggtcgc ccattttttc atcatttaac     2820

ctatcttcca gaaactacat gattaaatat gtttaagaag attagttacc attgaaattg     2880

gttctgtcat aaaacagcat gagtctggtt ttaaattatc tttgtattat gtgtcacatg     2940

gttatttttt aaatgaggat tcactgactt gtttttatat tgaaaaaagt tccacgtatt     3000

gtagaaaacg taaataaact aatatagact attcaaaaaa aaaaaaaaaa aa             3052


<210>  18
<211>  3830
<212>  DNA
<213>  homo sapiens

<400>  18
ggtgtttata agaatggaag tgttgtttcc ttgcccgatt ccttcatgct atatctcatg       60

aacctctgta atcttggggg agagactata tttaatgatg acaaacctgt caccagtgta      120

gcaacaacag tgtgaggaca aaagcaaata aaaattaaga agcgttcaaa tttatattca      180

acaaggaagt catttcaatc aacaacttct gctgcattat ttttccaaga tgaaccgata      240

cacaaccatg agacagttgg gggacggcac gtatgggagt gtgcttatgg gcaagagtaa      300

tgaatccggg gagctggtgg ccatcaaaag gatgaagaga aagttctatt cttgggatga      360

atgcatgaac ttgagagaag ttaagtctct gaagaaactt aatcatgcca atgttattaa      420

attgaaagaa gttatcagag aaaatgacca tctttatttt atatttgaat atatgaaaga      480

aaacctctat caattaatga aagacagaaa caagttgttc cctgaatcag tcatcagaaa      540

tattatgtat caaatattgc aagggctggc ttttatccat aaacatggct tttttcatag      600

ggacatgaaa ccagaaaact tgctttgtat gggtccagag cttgtgaaaa ttgctgattt      660

tggacttgca agagaattaa ggtcacagcc accatacact gattatgtat ctaccagatg      720

gtatcgtgcc cctgaagttt tactgagatc ttcagtttat agttctccca ttgatgtgtg      780

ggctgttgga agtatcatgg ctgaactcta tatgttaagg ccacttttcc cagggacaag      840

tgaggtcgat gaaatcttta aaatttgcca agttttaggg actcccaaaa aaagtgactg      900

gccagaagga taccagctgg catcctctat gaacttccgt tttccccagt gtgttcctat      960

aaacttaaaa actcttattc ccaatgccag taatgaagct attcagctca tgaccgaaat     1020

gttgaattgg gatccaaaga aacgaccgac agcaagccag gcattgaaac acccatattt     1080

tcaagttggt caggtattag gcccttcgtc aaatcatctg gaatcaaaac agtctttaaa     1140

taagcagctg caaccattag aatcaaagcc atctttagtt gaggtagagc ctaagcctct     1200

gccggatata atcgatcagg ttgttggaca accccagcca aaaactagcc agcagccact     1260

gcagcccatt cagccgccac agaacctgag cgtccagcaa cctccaaagc aacagagtca     1320

ggagaaaccg ccacaaacgc tattcccgag catcgtcaaa aacatgccaa ctaagccaaa     1380

tggcacactg agtcataaaa gtggtaggag gcgttggggt cagactatct tcaagtctgg     1440

agatagctgg gaagagttgg aggactatga tttcggagcc tcccattcca agaagccaag     1500

catgggtgtt tttaaagaaa aaaggaaaaa agattctcca tttcggcttc cagagccagt     1560

accctcaggc tccaaccact cgacagggga aaacaagagc ttacctgctg ttacttccct     1620

aaaatctgat tccgaattgt caactgctcc aacctctaaa cagtactact tgaaacaatc     1680

aagatatctt ccaggtgtga atcccaagaa ggtgtccttg atagccagtg gaaaggaaat     1740

aaacccccac acttggagca accagttatt ccccaagtca ctgggacccg ttggggcaga     1800

acttgctttc aaaaggagca atgcaggaaa tcttggaagt tatgctactt acaatcagtc     1860

aggatatatt ccttcctttc tcaaaaaaga agtgcagtca gctggccaga ggatccactt     1920

agcacctctc aatgcaacgg cttcagaata tacctggaac acaaaaactg gtcgggggca     1980

gttttcagga cgtacttata atcctacagc aaaaaaccta aatattgtga accgtgcaca     2040

gcccattccc tcagtgcatg ggaggacaga ctgggtggcc aagtatggag gccaccggta     2100

ggagtctatg gtgtgaaacc ctacagcatt gctccgtaga gtacgtgcaa gttccttgac     2160

cctgggaaat gtctacaaat gtctatttct actgagttct ggaagaaata tgcaaaagtg     2220

ggtacttgga agggcaaaaa tcatccccta ttttacttat ttccaagaaa tgcattttct     2280

tagcatcatt gcccacagtg ttgatatatg ggtaggatgt tacaaagtat tgaataaact     2340

atttgccaaa gtatgaagta tttgatctac aatttaataa atagtaaatc caataagaac     2400

ccttaaaaaa aaacaacttc cagaaaatgt ttagagtgtt ttagttttca tttgttgtat     2460

gtgcccaaat ggtttagtag ttcttcactt tgctgtggtt ggcttaagag gtttgtcttt     2520

tgtttttgta cagcagttgg gccaaccttt gctggctgtc agctgtggtt cttatttgac     2580

taaggctctg cgctgccatt ttgtcaatga cagaaagatt gcaattattt gtttttctac     2640

tttgaagcta tgggagcgat ggtaatttca atcttgagca ggatatcttt tttttttttt     2700

ttgaggcgat gtttcactct tgtgtccagg ctggagtgca gtggcactat cttggcttac     2760

tgcaacctcc acctcctggg ttcaagtgat tctcctgcct cagcctcccg agtagctggg     2820

attagaggcg tgtgccacca tgcctggcta atttttgtag tattagtaga gacagggttt     2880

caccatgttg gtcaggctca ggctggtctc aaactcctga cctcaggtga tccacctgcc     2940

tcggcctccc aaagtgcagg gcttacaggt gtgagccaca gtgcccagct tttttttttt     3000

ttttttagaa ataaatttat ctttaacata gagaatatca aagttatgcc acttgatttt     3060

agtggacggc ttgtgttttg atcttgacca gtacagttcc catgaattca aggtgacaat     3120

caagcccaat ggcttgatga cttcaatagt aaccaagtca aggttctctt ggctggacat     3180

cattaagaaa gttctggaaa ctgtgtttgt ttgatgctgg ttcattggac ttttcaaatt     3240

gttttgtttc tgtgtcccta ccagacacaa agatgaagtg tgccagctgg ttcccccaag     3300

ccagctcatg ctgctgacca ctgactcagc tctgaccttc acatttgctc tgaagcaagt     3360

gcgttcagct gctggggcag tgatatcaca tagtacatat attatttcct tagtttattt     3420

ccaaactggt attttaaata gacacttcga actttgggct actctgttta aatctgccac     3480

tttctggact ggaccttagt actgtaaatt ctttttaaag aataataatg ttaccaactg     3540

ctgagatttt tatgtatttt gtgactttgt aacaactgct attgtaataa gtgtcatctt     3600

gtgggcatta tacaaaggca tattataaaa taataatgat atttttgtat agaagagtca     3660

actgttcaga tgtaagatgt tgaaaaatgt taaaatctaa agagtaattt atcctagtgg     3720

taatggttat atgtatttgt acagtttaaa ttaatgtctc aaagctgtgc agtcttttgt     3780

tactgggaca cttttaaact ctgaataggc attaaaaaaa atatggctaa                3830


<210>  19
<211>  8025
<212>  DNA
<213>  homo sapiens

<400>  19
cggcgctgct ggaagatggc gagcggccgg gacgagcggc cgccttggcg gctagggcgg       60

ctcctgttgc tcatgtgcct gctgctgctg gggagctcgg cccgggcggc tcacatcaag      120

aaggcggagg cgactaccac aactacgagc gcgggcgccg aggcggccga gggccagttc      180

gaccgctact accacgaaga ggagttggag tcggcgctga gggaggcggc ggccgcgggc      240

ctccccggcc tggcccgcct ctttagcatc ggccgctcgg tggaaggccg gccgctgtgg      300

gtgcttcgcc tcaccgccgg cctggggtcg ctaatccctg agggcgacgc ggggcctgac      360

gctgccgggc ccgacgctgc ggggccgctg ctgcccggcc ggccccaggt gaagctggtg      420

ggcaacatgc atggcgacga gaccgtgtcg cgccaggtgt tgatctactt ggcccgcgag      480

ctggcggccg gctaccgccg cggggacccg cgcctggtcc gcctgctcaa caccaccgac      540

gtgtacctgc tgcccagcct caaccccgat ggcttcgagc gtgcccgcga gggcgactgt      600

ggcttcggcg acggcggccc gtccggggcc agcggccgcg acaatagtcg cggccgcgac      660

ctcaaccgaa gctttcccga ccagtttagc accggcgaac cccccgccct ggacgaggtg      720

cccgaggtgc gcgccctcat cgagtggatc cgcaggaaca agtttgtgct ttctggaaat      780

ctgcatggtg gctcagtggt agcaagctat ccttttgatg attctccaga acataaggcc      840

actggaatct atagcaaaac ctcagatgat gaagtattta aatacttggc aaaagcttat      900

gcttcaaacc accccataat gaaaactggt gagcctcatt gtccaggaga tgaagacgag      960

actttcaaag atggaatcac aaacggcgca cattggtatg atgtggaagg tggtatgcaa     1020

gattacaatt atgtgtgggc caactgtttt gagatcacat tagaactgtc ttgttgcaag     1080

tacccacctg cttcacagct tcgacaggaa tgggagaaca atcgtgagtc tttgatcaca     1140

ttgattgaaa aggttcacat tggagtgaaa ggatttgtta aagattccat aacaggatct     1200

gggttagaga atgcaaccat ctcagtggct ggtattaatc ataatatcac aacaggcaga     1260

tttggtgatt tctaccgatt acttgttcct ggaacttaca accttacagt agttttaact     1320

gggtatatgc cattgactgt tactaatgta gtggtgaaag aaggaccagc cacagaggtg     1380

gatttttctc ttaggccaac tgtaacttca gtaatccctg acacgacaga ggctgtatca     1440

actgctagca cagttgctat acctaatatt ctttctggaa catcatcctc ctaccagcca     1500

attcagccaa aggactttca ccaccaccat ttccctgata tggaaatctt cttgagaagg     1560

tttgccaatg aatatcctaa cattacccgg ctttattcct tgggaaaatc agtagagtca     1620

agagaacttt atgtgatgga gatatctgat aatccgggtg tccatgaacc aggtgaacca     1680

gaatttaagt acattggaaa tatgcatgga aatgaagtgg ttggaagaga actgctgttg     1740

aacctcatag aatacctttg taagaacttt ggaacagacc ctgaagtcac agatttggtt     1800

cataacacta gaattcacct tatgccatcc atgaatcctg atgggtatga aaagtcccag     1860

gaaggagatt caataagtgt aattggcaga aacaacagca acaactttga cctgaaccga     1920

aatttcccag accagtttgt tcagatcaca gatcctacgc aaccagaaac tattgctgta     1980

atgagctgga tgaagtccta tccatttgta ctttcagcaa acctgcatgg aggttctttg     2040

gtggttaact acccttttga tgatgatgaa caaggacttg ccacatatag taaatcacca     2100

gatgatgctg tgttccaaca aatagcactt tcttattcca aggaaaattc ccagatgttt     2160

caaggtagac cttgcaagaa tatgtatcct aatgaatatt ttcctcatgg aataacaaat     2220

ggagctagtt ggtataatgt gccaggagga atgcaggact ggaactattt acaaacaaat     2280

tgctttgaag tgactattga actaggttgt gtgaaatatc cacttgagaa agagctgcca     2340

aacttttggg aacagaatcg aagatcacta atccagttta tgaaacaggt tcatcagggc     2400

gtcagaggat ttgttctaga tgccacagat ggcaggggta tattaaatgc caccattagt     2460

gttgctgaga ttaatcaccc agtgactact tacaaaactg gagattactg gcgtctcttg     2520

gttccaggaa cttataaaat cacagcatct gctcgagggt ataatccagt taccaagaat     2580

gtgactgtca agagtgaagg cgctattcag gtcaacttca cacttgttcg atcctcaaca     2640

gattcaaaca atgaatcaaa gaaaggaaaa ggggctagca gcagcaccaa tgatgccagt     2700

gatccaacta ctaaagagtt tgaaacttta attaaagacc tttcagcgga gaatggtttg     2760

gaaagcctca tgttacgctc ctcctcaaat ctggctctgg ctctttatcg ataccattcc     2820

tacaaagact tatcagagtt tctgagagga cttgtaatga actatccaca tattacaaat     2880

cttaccaatt tgggacagag cactgaatat cgtcacattt ggtcccttga aatctccaat     2940

aagcccaatg tatctgagcc tgaagaacca aagattcgtt ttgttgctgg tatccatgga     3000

aatgcgccag ttggaactga actgcttttg gctctggcag aatttctctg cctgaactac     3060

aaaaagaacc cagctgttac ccaattggtt gacaggacta ggattgtgat tgtcccttct     3120

ctaaatccag atgggcgaga gagagctcaa gagaaagact gtacttcaaa aataggacaa     3180

acaaatgctc gtggcaaaga tttggataca gacttcacaa ataatgcctc ccaacctgag     3240

accaaagcca tcattgaaaa tttgattcaa aaacaggact ttagtctttc tgttgcctta     3300

gatggtggtt ccatgctggt cacatatcct tatgacaagc cagtacagac agtggaaaat     3360

aaagagactc tgaagcattt ggcatctctt tatgcaaata atcatccatc catgcacatg     3420

ggtcagccca gttgcccaaa taaatcagat gagaatattc caggaggagt aatgcgtgga     3480

gcagaatggc atagtcacct gggcagcatg aaggattata gtgtcaccta tggccattgt     3540

ccggaaatca cagtatacac aagctgctgt tactttccta gtgctgcacg actcccttcc     3600

ttgtgggcag acaataagag atctcttctt agtatgttag tggaggttca caagggagtt     3660

catggatttg ttaaagataa gactggaaag ccaatctcta aagcagtcat tgtacttaat     3720

gaaggaataa aggtacaaac aaaagaggga ggttatttcc atgtactctt agcgccaggt     3780

gtccataaca ttattgccat cgctgatggg taccagcaac aacattcaca ggtctttgtg     3840

catcatgatg cagctagttc tgtggtgata gtctttgaca cagataaccg gatatttggt     3900

ttgccaaggg agcttgtggt aactgtatca ggtgctacta tgtcggcatt gatcctaaca     3960

gcttgcatta tttggtgcat ctgctcaatc aagtctaata gacacaagga tggctttcat     4020

cggctcaggc agcatcatga tgagtatgaa gatgaaattc gcatgatgtc taccggctcc     4080

aagaagtccc tcctaagcca tgagttccag gatgaaacag acactgaaga ggaaacatta     4140

tattctagca aacattgaaa aacacatttt gcatatctcc cagcataagt accaagcaaa     4200

attacagttc ctcttgggag aacactgcat taagaagaga gactctcttg cttcttcaaa     4260

gagctttggg aaattaaatt gctaaatttg tattctctgt gaatttcact ggcagttttg     4320

aacttccctt ccttaaagta ctctaaacct ttaaaaaaaa atctgattta tgcagcagag     4380

atgggacagc cactttttct ttttaattta agatgagcta tttggagctt atgtaataat     4440

ggcataaagc caactagagg atgttgtatt ttgcacatca gatgtttact agtggcttta     4500

gtatttttct ttgttttaaa tggccaaaag aatccagaaa cattaaggca gggacagcag     4560

tcagaatcga cataaagctt taaaaactca aggttttttc aacctactga ggagtacttt     4620

tctctagttg ttaaatagct ggagtttttc ttattcaggt ttaatggagg ttgaattgat     4680

ttttaaacac atataacagt aggaaatgaa taaatgggct tctgcatttg gctttctacc     4740

tgttccaagg ctagatcgga actggtagac tacgctgtaa gcaggatttc actacctctc     4800

ttaaggttta gcaaacttct aaatagccca ttttaaggga gaacttacta actttattgt     4860

gaaaggtcta aatgcccact tgaatgaagc tgagagagag atctagcaaa agctaaaact     4920

catgttgtct atctttgaac ttggtaaaaa cccacaggtg ctgctgctta tatctgtgaa     4980

gcactagctt attctaggaa tgcctgattc tttaatattg cctaaatcgg aacctttttc     5040

tatgttgcac acatggtttt cagatgaccc agccatctac aagatctgaa ttctactgaa     5100

aatatctaga aatgtggaag agacctactt gcacattctt aacctgtatt tgaacacaaa     5160

atatctatac ttcatgctcc agcccaagcc tataccctgt aatagcatac tattattgaa     5220

atcgcttgac cggtcttgtt cacataggcc tctgggagtg atttggttct ttgccctaat     5280

gtttcatttg acggtctctt tttgatcaac caatttttct aaaagttcag tcgaaagctt     5340

ttaagtatag cttcctccct tgaaaaaaaa tgtaaactat gactgctgag tgataaaaca     5400

ctgtggtgtg aaagtgtcat cttcactgcc aatcaggcaa agaccggaaa gatttgcatt     5460

ttattatgtc tgtcttatca tgcaatggaa atgatgcttt ttgtaagtat gcatcttacc     5520

aatgatgtaa cggtttaata cctttgaatg ttttaataac caagttgctg ctgaacttat     5580

actaaatcag gggaccaaaa aacttgctct tatcttctca aattgtattc tatatccatt     5640

aatgtatcag ttatcccaaa gccttcaggt ggaggggttt accaccttcc taggtcgttc     5700

aaccaggttt tgtgaggaat gcattcaaag tggctttata aaagaagatt ttctttagca     5760

agaataatga ggtcatgtca tttgttaata agtatctgtg ataaatccgt ggttcaaggt     5820

taagccattc tggtattctg gtattagcaa ctgtaaattc tgccacctca tacatggaac     5880

agagcttgtg ggatgctaat agttagtgaa gtatacatga tttaatttct aataatcttt     5940

atgttttctt taaggatggt ggtgtattgc tctttttcag ctttattttt aagagtacag     6000

tcaggaaacc aacaaggggc ctaagagtgg ctgcccctgc ttgggacatt acagcaagtg     6060

aaacaaagtt aatgtgacaa gctttgcttt gttatcattg gtcttcacta gaggatacct     6120

tttacatgta cttctctctt ggatcaaata tgtctttaac tgtacatctc agtggctgga     6180

ggccatgcct tttaagcatg tgtaaaattt ttaaagaaat gaacatacac atagttattt     6240

tagtaatatt tcctgaaaga aaaaccaaat tctgctataa gtcttgatct tcaatgaact     6300

tttaaataat gcatttagct ggaaaacaag actttcccag cttgtattac ctagaagcgt     6360

gaatgtatag gatacctgac tactaagact atattctcag ccctgccctg tcttttattt     6420

gcgggtctaa tctaatatta gaatatatta accgcttaag gcattgaagc catatgggat     6480

ggggaatgca tttcttcagt gtttctccga gagactttcc atttccttgg agttatggcg     6540

gcaagtaagt atcatagtat taagaaattt gcctaaatct gagttgtgcc tttctttact     6600

cacaaggcat gggctttgtc ctggtgatca gtttgtaagc cttcttcctt cccagctcct     6660

taataaaagc aaagtgattg agtaggtaat gttcaaagtg tctgcctgtg tacatgtact     6720

tgtattgatt atgtagttca gtaagatgtg cccaagtcat ttcagaaaga aagacccttc     6780

agttttgatg cattttgctg aacacttggg tagtgagtgg gatcctatcc agttgaggaa     6840

tgcttgcaat gctcattgaa gggatttgct ttgggacttt gtcatcttcc agaaaggaaa     6900

catattgtat atttggccca gtgtgattga ttgctttatc tttggtaact tttacttgaa     6960

tgggatttgc tgaattaatg actattgaat ttaaaactaa ttatgagttg acaaataaat     7020

aaaaggtagt gtttatgtct gagcttattg tgtttgagct aacaccaggt tactcagtaa     7080

ccatgacctg ctcctccatt tccatttatt ctcaacatta aatagtttta tcttgttgtt     7140

gccagaaatg cacttgtgcc aggtattgtc cctgctgtat gaaaagcttc ttggcaatga     7200

attctgtaat agtgccctac attatggttt tctggtggaa ttgttttaac agtgacaacc     7260

caggatttcc aatatatttt tgttttattg ttattaccaa aaattccact atgattgatg     7320

ttcagtgatt ttctatagca acttttttgg taactctttg ggtttctgat ttgttttagc     7380

taaaattttg gggatatgat ttgggtcttt gattaatgtc agctgaactt ggatttctag     7440

ttcatgaaga aatctctccc aatacccatt tatcctattt ttagcaataa ttcgttaatg     7500

attccacttg attttcagaa tattgtcctg gttgattttg atttgacagc atacattatg     7560

aaatttgaaa gtaggttacc attttgaggc agttggatat aaattatgta aatatgtatg     7620

attatgattt ttataaatgg cataacatga gtgtactaac taccttctat gctggccatg     7680

ctacagattt tctggaggta tgacaatagt atttttttat gctcagatta aaaatcagct     7740

tttcacctct ccagtttttc caagtgatac tcccagttct agagcaatct acagctgttt     7800

atgtgaggtg cccaacaccc attcatctca agtgcttcag tctttggttt atttcatgca     7860

ctgtgccttc aaaatgaaat ttttaaaagg gactttaaat gaagttgaat agtagttttt     7920

aaaagtcaat ttgtaattta tgtgaaatct aactgtaatg aggtcctttc tgttttttat     7980

atgtaaacag atctactaat cctgtataaa agttatttta cgatg                     8025


<210>  20
<211>  928
<212>  DNA
<213>  homo sapiens

<400>  20
gctgtggccc tggcacctgc ccctgggctg ggacagccca ctgttccatg ctgcccaaga       60

aggctcagca caggcacaaa ccattgcccg gcactggccc gtgctgcctg agaaggattg      120

gcacgggcac agaccactgc ccccacctgc cctgcgccat ctacccaaga aggctcggca      180

cgggcaccaa ccactgcctc caactgcccc atgctgcctg agaaggcact gcacggccac      240

ccccaactgc cccgcactgt ccctacccgg gcagccatgc gagcggctgg aactctgctg      300

gccttctgct gcctggtctt gagcaccact gggggccctt ccccagatac ttgttcccag      360

gaccttaact cacgtgtgaa gccaggattt cctaaaacaa taaagaccaa tgacccagga      420

gtcctccaag cagccagata cagtgttgaa aagttcaaca actgcacgaa cgacatgttc      480

ttgttcaagg agtcccgcat cacaagggcc ctagttcaga tagtgaaagg cctgaaatat      540

atgctggagg tggaaattgg cagaactacc tgcaagaaaa accagcacct gcgtctggat      600

gactgtgact tccaaaccaa ccacaccttg aagcagactc tgagctgcta ctctgaagtc      660

tgggtcgtgc cctggctcca gcacttcgag gtgcctgttc tccgttgtca ctgacccccg      720

cctcttcagc aagaccacag ccatgacaaa caccaggatg catgctcctt gtcccctccc      780

acccgcctca tgacccagcc tcacagaccc tctcaggcct ctgacgagtg agcgggtgaa      840

gtgccactgg gtcaccgcag ggcagctgga atggcagcat ggtagcacct cctaacagat      900

taaatagatc acatttgctt ctaaaatt                                         928


<210>  21
<211>  2545
<212>  DNA
<213>  homo sapiens

<400>  21
actcattcac ataaaacgct gcgcggccgg cggaatcccc ggcttctagg gcggcgagcg       60

gccgggctgg ctatcgagcg agcggggcgg gaacgcggag ttgcgccgcc gctcgggcgc      120

cgggctccgt cgcggccgca gccccgcggg tcgccctccc gtgcctcgcc cgcggacacc      180

ctggccgtgg acaccctggc cgtgggcacc cgcggggcgc gcggcgcggg gccgctggcc      240

ggcggcggcg gcggcatgaa ggtcacgtcg ctcgacgggc gccagctgcg caagatgctc      300

cgcaaggagg cggcggcgcg ctgcgtggtg ctcgactgcc ggccctatct ggccttcgct      360

gcctcgaacg tgcgcggctc gctcaacgtc aacctcaact cggtggtgct gcggcgggcc      420

cggggcggcg cggtgtcggc gcgctacgtg ctgcccgacg aggcggcgcg cgcgcggctc      480

ctgcaggagg gcggcggcgg cgtcgcggcc gtggtggtgc tggaccaggg cagccgccac      540

tggcagaagc tgcgagagga gagcgccgcg cgtgtcgtcc tcacctcgct actcgcttgc      600

ctacccgccg gcccgcgggt ctacttcctc aaagggggat atgagacttt ctactcggaa      660

tatcctgagt gttgcgtgga tgtaaaaccc atttcacaag agaagattga gagtgagaga      720

gccctcatca gccagtgtgg aaaaccagtg gtaaatgtca gctacaggcc agcttatgac      780

cagggtggcc cagttgaaat ccttcccttc ctctaccttg gaagtgccta ccatgcatcc      840

aagtgcgagt tcctcgccaa cctgcacatc acagccctgc tgaatgtctc ccgacggacc      900

tccgaggcct gcgcgaccca cctacactac aaatggatcc ctgtggaaga cagccacacg      960

gctgacatta gctcccactt tcaagaagca atagacttca ttgactgtgt cagggaaaag     1020

ggaggcaagg tcctggtcca ctgtgaggct gggatctccc gttcacccac catctgcatg     1080

gcttacctta tgaagaccaa gcagttccgc ctgaaggagg ccttcgatta catcaagcag     1140

aggaggagca tggtctcgcc caactttggc ttcatgggcc agctcctgca gtacgaatct     1200

gagatcctgc cctccacgcc caacccccag cctccctcct gccaagggga ggcagcaggc     1260

tcttcactga taggccattt gcagacactg agccctgaca tgcagggtgc ctactgcaca     1320

ttccctgcct cggtgctggc accggtgcct acccactcaa cagtctcaga gctcagcaga     1380

agccctgtgg caacggccac atcctgctaa aactgggatg gaggaatcgg cccagcccca     1440

agagcaactg tgatttttgt ttttaagact catggacatt tcatacctgt gcaatactga     1500

agacctcatt ctgtcatgct gccccagtga gatagtgagt ggtcaccagg cttgcaaatg     1560

aacttcagac ggacctcagg gtaggttctc gggactgaag gaaggccaag ccattacggg     1620

agcacagcat gtgctgacta ctgtacttcc agacccctgc cctcttggga ctgcccagtc     1680

cttgcacctc agagttcgcc ttttcatttc aagcataagg caataaatac ctgcagcaac     1740

gtgggagaaa gaagttgctg gaccaggaga aaaggcagtt atgaagccaa ttcattttga     1800

aggaagcaca atttccacct tattttttga actttggcag tttcaatgtc tgtctctgtt     1860

gcttcggggc ataagctgat caccgtctag ttgggaaagt aaccctacag ggtttgtagg     1920

gacatgatca gcatcctgat ttgaaccctg aaatgttgtg tagacaccct cttgggtcca     1980

atgaggtagt tggttgaagt agcaagatgt tggcttttct ggattttttt tgccatgggt     2040

tcttcactga ccttggactt tggcatgatt cttagtcata cttgaacttg tctcattcca     2100

cctcttctca gagcaactct tcctttggga aaagagttct tcagatcata gaccaaaaaa     2160

gtcatacctt cgaggtggta gcagtagatt ccaggaggag aagggtactt gctaggtatc     2220

ctgggtcagt ggcggtgcaa actggtttcc tcagctgcct gtccttctgt gtgcttatgt     2280

ctcttgtgac aattgttttc ctccctgccc ctggaggttg tcttcaagct gtggacttct     2340

gggatttgca gattttgcaa cgtggtacta cttttttttt ctttttgtct gttagttatt     2400

tctccagggg aaaaggcaat aattttctaa gacccgtgtg aatgtgaaga aaagcagtat     2460

gttactggtt gttgttgttg ttcttgtttt ttatagtgta aaataaaaat agtaaaagga     2520

gaaaagcaaa aaaaaaaaaa aaaaa                                           2545


<210>  22
<211>  6648
<212>  DNA
<213>  homo sapiens

<400>  22
acatgttact tcctgtatgg aggcatggcc agtttccagc cccgcgctct tcgttccttc       60

ccagcctgcg ccggagccac aactttcagg agcatggact gaaggcgccc tcgccccagc      120

gcccctctga gatcctttgt gttttcctcc gtttcctccg gccgtttcta ttttgggggg      180

ctctccgctc cccctgcctc tcccctcccc ttcccctctc gcaaacatgc ctccttcctt      240

cccggggccc tggaaggagc tgcctgcctg aagcccggag acgccgcgcc gcgctcagcc      300

ccgccgccgc ccgccggctc tcgggctgtg ctgcgctgcc gactcaagtt ggggatcctc      360

ggctgctcgc cgccgccgcc cgcggtccct gcctgcccca ggcccggggc atcgccgccg      420

gccgccgact ccgcgccctg cccgatcggc tctctccttt ttaaacggaa agcagccttt      480

ctccgccgag aggatcgtcc ccagcgtggc tctgcgttcc cggtcacttt ttgagatttt      540

ccggggggcg ctcggcggct tcccggattc caaggggact cgggccgccg agcgcggggg      600

gcccgtggag cgggcgagcc ggggaagcgc cccggcttag cggaggctcg cacggaggca      660

agaacttatt caacaagttt acctccctgc tttcctcttt tcgatgtgcg ttttcggaca      720

tgcggaggtt actggaaccg tgttggtgga ttttgttcct gaaaatcacc agttccgtgc      780

tccattatgt cgtgtgcttc cccgcgttga cagaaggcta cgttggggcc ctgcacgaga      840

atagacacgg cagcgcagtg cagatccgca ggcgcaaggc ttcaggcgac ccgtactggg      900

cctactctgg tgcctatggt cctgagcact gggtcacgtc tagtgtcagc tgtgggggcc      960

gtcaccagtc tcctattgac attttagacc agtatgcgcg tgttggggaa gaataccagg     1020

aactgcaact cgatggcttc gacaatgagt cttctaacaa aacctggatg aaaaacacag     1080

ggaaaacagt cgccatcctt ctgaaagacg actattttgt cagtggagct ggtctacctg     1140

gcagattcaa agctgagaag gtggaatttc actggggcca cagcaatggc tcagcgggct     1200

ctgaacacag catcaatggc aggaggtttc ctgttgagat gcagattttc ttttacaatc     1260

cagatgactt tgacagcttt caaaccgcaa tttctgagaa cagaataatc ggagccatgg     1320

ccatattttt tcaagtcagt ccgagggaca attctgcact ggatcctatt atccacgggt     1380

tgaagggtgt cgtacatcat gagaaggaga cctttctgga tcctttcgtc ctccgggacc     1440

tcctgcctgc atccctgggc agctattatc ggtacacagg ttccttgacc acaccaccgt     1500

gtagcgaaat agtggagtgg atagtcttcc ggagacccgt ccccatctct taccatcagc     1560

ttgaggcttt ttattccatc ttcaccacgg agcagcaaga ccatgtcaag tcggtggagt     1620

atctgagaaa taactttcga ccacagcagc gtctgcatga cagggtggtg tccaagtccg     1680

ccgtccgtga ctcctggaac cacgacatga cagacttctt agaaaaccca ctggggacag     1740

aagcctctaa agtttgcagc tctccaccca tccacatgaa ggtgcagcct ctgaaccaga     1800

cggcactgca ggtgtcctgg agccagccgg agactatcta ccacccaccc atcatgaact     1860

acatgatctc ctacagctgg accaagaatg aggacgagaa ggagaagacg tttacaaagg     1920

acagcgacaa agacttgaaa gccaccatta gccatgtctc acccgatagc ctttacctgt     1980

tccgagtcca ggccgtgtgt cggaacgaca tgcgcagcga ctttagccag acgatgctgt     2040

ttcaagctaa taccactcga atattccaag ggaccagaat agtgaaaaca ggagtgccca     2100

cagcgtctcc tgcctcttca gccgacatgg cccccatcag ctcggggtct tctacctgga     2160

cgtcctctgg catcccattc tcatttgttt ccatggcaac tgggatgggc ccctcctcca     2220

gtggcagcca ggccacagtg gcctcggtgg tcaccagcac gctgctcgcc ggcctggggt     2280

tcggcggtgg tggcatctcc tctttcccca gcactgtgtg gcccacgcgc ctcccgacgg     2340

ccgcctcagc cagcaagcag gcggctaggc cagtcctagc caccacagag gccttggctt     2400

ctccagggcc cgatggtgat tcgtcaccaa ccaaggacgg cgagggcacc gaggaaggag     2460

agaaggatga gaaaagcgag agtgaggatg gggagcggga gcacgaggag gatggagaga     2520

aggactccga aaagaaggag aagagtgggg tgacccacgc tgccgaggag cggaatcaga     2580

cggagcccag ccccacaccc tcgtctccta acaggactgc cgagggaggg catcagacta     2640

tacctgggca tgagcaggat cacactgccg tccccacaga ccagacgggc ggaaggaggg     2700

atgccggccc aggcctggac cccgacatgg tcacctccac ccaagtgccc cccaccgcca     2760

cagaggagca gtatgcaggg agtgatccca agaggcccga aatgccatct aaaaagccta     2820

tgtcccgcgg ggaccgattt tctgaagaca gcagatttat cactgttaat ccagcggaaa     2880

aaaacacctc tggaatgata agccgccctg ctccagggag gatggagtgg atcatccctc     2940

tgattgtggt atcagccttg accttcgtgt gcctcatcct tctcattgct gtgctcgttt     3000

actggagagg gtgtaacaaa ataaagtcca agggctttcc cagacgtttc cgtgaagtgc     3060

cttcttctgg ggagagagga gagaagggga gcagaaaatg ttttcagact gctcatttct     3120

atgtggaaga cagcagttca cctcgagtgg tccctaatga aagtatccct attattccta     3180

ttccggatga catggaagcc attcctgtca aacagtttgt caaacacatc ggtgagctct     3240

attctaataa ccagcatggg ttctctgagg attttgagga agtccagcgc tgtactgctg     3300

atatgaacat cactgcagag cattccaatc atccagaaaa caagcacaaa aacagataca     3360

tcaacatttt agcatatgat cacagtaggg tgaagttaag acctttacca ggaaaagact     3420

ctaagcacag cgactacatt aatgcaaact atgttgatgg ttacaacaaa gcaaaagcct     3480

acattgccac ccaaggacct ttgaagtcta catttgaaga tttctggagg atgatttggg     3540

aacaaaacac tggaatcatt gtgatgatta cgaaccttgt ggaaaaagga agacgaaaat     3600

gtgatcagta ttggccaaca gagaacagtg aggaatatgg aaacattatt gtcacgctga     3660

agagcacaaa aatacatgcc tgctacactg ttcgtcgttt ttcaatcaga aatacaaaag     3720

tgaaaaaggg tcagaaggga aatcccaagg gtcgtcagaa tgaaagggta gtgatccagt     3780

atcactatac acagtggcct gacatgggag ttcccgagta tgcccttcca gtactgactt     3840

tcgtgaggag atcctcagca gctcggatgc cagaaacggg ccctgtgttg gtgcactgca     3900

gtgctggtgt gggcagaaca ggcacctata ttgtaataga cagcatgctg caacagataa     3960

aagacaaaag cacagttaac gtcctgggat tcctgaagca tatcaggaca cagcgtaact     4020

acctcgtcca gactgaggag cagtacattt tcatccatga tgccttgttg gaagccattc     4080

ttggaaagga gactgaagta tcttcaaatc agctgcacag ctatgttaac agcatcctta     4140

taccaggagt aggaggaaag acacgactgg aaaagcaatt caagctggtc acacagtgta     4200

atgcaaaata tgtggaatgt ttcagtgctc agaaagagtg taacaaagaa aagaacagaa     4260

actcttcagt tgtgccatct gagcgtgctc gagtgggtct tgcaccattg cctggaatga     4320

aaggaacaga ttacattaat gcttcttata tcatgggcta ttataggagc aatgaattta     4380

ttataactca gcatcctctg ccacatacta cgaaagattt ctggcgaatg atttgggatc     4440

ataacgcaca gatcattgtc atgctgccag acaaccagag cttggcagaa gatgagtttg     4500

tgtactggcc aagtcgagaa gaatccatga actgtgaggc ctttaccgtc acccttatca     4560

gcaaagacag actgtgcctc tctaatgaag aacaaattat catccatgac tttatccttg     4620

aagctacaca ggatgactat gtcttagaag ttcggcactt tcagtgtccc aaatggccta     4680

acccagatgc ccccataagt agtacctttg aacttatcaa cgtcatcaag gaagaggcct     4740

taacaaggga tggtcccacc attgttcatg atgagtatgg agcagtttca gcaggaatgt     4800

tatgtgccct taccaccctg tcccagcaac tggagaatga aaatgctgtg gatgttttcc     4860

aggttgcaaa aatgatcaat cttatgaggc ctggagtatt cacagacatt gaacaatacc     4920

agttcatcta taaagcaatg cttagcttgg tcagcactaa agaaaatgga aatggtccca     4980

tgacagtaga caaaaatggt gctgttctta ttgcagatga atcagaccct gctgagagca     5040

tggagtccct agtgtgactg gaatcctgaa agggcactta atttgtaaac ttctgaagac     5100

tgagaacttt tttgaggcct tttttgccag actctaggtt atacaataac ccagttactt     5160

ttttacactg ataaaagttt tgatatttat tttttgccat tttatgtctt aatggtatcc     5220

tactgagcat ttgcacctct gttcatttca cacagtgaaa cgcaatttta cctagtttgc     5280

actatatgat cagtgttact gcctataatc ttatacaaca gcaaaccctg atgtgacatt     5340

ccatgacgac atacatgcta ctttttttta gttcaataca gtgaaggtct ttgttatgac     5400

agtgaatatt gcttttatta ttattattgc tgaagtggtt gcattctact agcaggcaat     5460

gctgtacttt tcttcagtcc tcctctcctt tttattttag gcactgttca atactgtatg     5520

ccttctgtat tttaatggag tggatagcat tgttttcttt tacagactag caggctactg     5580

ggacctaaaa aggtctgtta atgtcatggc cttgaaacag ttccatttat gctggttaag     5640

agatccctta agaagttaga aggcttaaga actgcttcat gtgaacatcc cttattagtt     5700

acaaagttat attcacagtt ttttaaaaat gtgtcaaaat aaaggataac tctgtattac     5760

agctttcaca gtagctatgt ggacaatgtg ttatttccat tttgactctc taaaatagct     5820

acatcctaaa atcagggcta tctttaacaa tagcaagata gcaatattat atacaactca     5880

gttatgagac cctttagtta ttctccatta atgcttctta gtttgtaata ccatacctca     5940

cagtaggtag aagaatgaaa acttctgcag gtgtgtaatt ttgaaactag tcctctaaaa     6000

attccctatt actcctatag caatctaata aaaactacct acatagttac tgttttcttt     6060

ccttctttgc caaatgtttt ataataaatc tcttaattac atacattttt ctacttaaga     6120

ttaaattgga aatactgtct tagcaaaagt cttgggacta tctaaactcc cacacataga     6180

taaatctgat ttggagagag aaatttaaaa tatttaatta aaggtgatac ccacattttc     6240

aagtttttaa aagagggaga tggctttgta tgcttttgtg tagtttagaa cagatacaca     6300

ttagtaaaag ataccaataa tcattagagc tcaaggaagt tattaggtgc agcctctgga     6360

gccatactca cgctgcagtg cataatggga aaattaggag cattaataag aaatttcagt     6420

agtgtttgta aggaaaataa gctacttact gagatctgtt tcttctattg catgtttgct     6480

tttgagggac agcttctgtc aaaagtgaaa tcatcaccag aactgggcct gttaggaaga     6540

atagggtttt atttactttt tatgtcaatt aacttcaaca aaaaggccac gctggctgct     6600

gtcatgccat ctgggtatgc attaaacatt aatgatgatc agcactga                  6648


<210>  23
<211>  4176
<212>  DNA
<213>  homo sapiens

<400>  23
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt       60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac      120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc      180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag      240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct      300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc      360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg      420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg      480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc      540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca      600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg      660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt      720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg      780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg      840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga      900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct      960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg     1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc     1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca     1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc     1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc     1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc     1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt     1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta     1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc     1500

cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg     1560

ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc     1620

gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc     1680

cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca     1740

gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga     1800

gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc     1860

agcagcctgg accctgtgga tgataaaaca caaacgggct cagcaaaaga tgcttctcac     1920

tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga     1980

aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa     2040

cctccctttc caaatgccca gcttaaaggg gctagagtga acttgggcca ctgtgaagag     2100

aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg     2160

gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca     2220

ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc     2280

ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgcct tagcaaattc     2340

tgtttttcta ggcctgggga cggcttttac ttaaaccgcc aaggctgggg gaagaagctc     2400

tctcctccct ttcttcccta cagttgaaaa acagctgagg gtgagtgggt gaataataca     2460

gtatctcagg gcctggtcgt tttcaacaga attataatta gttcctcatt agcattttgc     2520

taaatgtgaa tgatgatcct aggcatttgc tgaatacaga ggcaactgca ttggctttgg     2580

gttgcaggac ctcaggtgag aagcagagga aggagaggag aggggcacag ggtctctacc     2640

atcccctgta gagtgggagc tgagtggggg atcacagcct ctgaaaacca atgttctctc     2700

ttctccacct cccacaaagg agagctagca gcagggaggg cttctgccat ttctgagatc     2760

aaaacggttt tactgcagct ttgtttgttg tcagctgaac ctgggtaact agggaagata     2820

atattaagga agacaatgtg aaaagaaaaa tgagcctggc aagaatgtgt ttaaacttgg     2880

tttttaaaaa actgctgact gttttctctt gagagggtgg aatatccaat attcgctgtg     2940

tcagcataga agtaacttac ttaggtgtgg gggaagcacc ataactttgt ttagcccaaa     3000

accaagtcaa gtgaaaaagg aggaagagaa aaaatatttt cctgccaggc atggtggccc     3060

acgcacttcg ggaggtcgag gcaggaggat cacttgagtc cagaagtttg agatcagcct     3120

gggcaatgtg ataaaacccc atctctacaa aaagcataaa aattagccaa gtgtggtaga     3180

gtgtgcctga agtcccagat acttgggggg ctgaggtggg aggatctctt gagcctggga     3240

ggtcaaggct gcagtgagcc gagattgcac cactgcactc cagcctgggt gacagagcaa     3300

gtgagaccct gtctcaaaaa aagaaaaaga aaaagaaaaa atattttccc tattagagaa     3360

gagattgtgg tttcattctg tattttgttt ttgtcttaaa aagtggaaaa atagcctgcc     3420

tcttctctac tctagggaaa aaccagcgtg tgactactcc cccaggtggt tatggagagg     3480

gtgtccggtc cctgtcccag tgccgagaag gaagcctccc acgactgccc ggcagggtcc     3540

tagaaattcc ccaccctgaa agccctgagc tttctgctat caaagaggtt ttaaaaaaat     3600

cccatttaaa aaaaatccct tacctcggtg ccttcctctt tttatttagt tccttgagtt     3660

gattcagctc tgcaagaatt gaagcaggac taaatgtcta gttgtaacac catgattaac     3720

cacttcagct gacttttctg tccgagcttt gaaaattcag tggtgttagt ggttacccag     3780

ttagctctca agttatcagg gtattccaga gtggggatat gatttaaatc agccgtgtaa     3840

ccatggaccc aatatttacc agaccacaaa acttttctaa tactctaccc tcttagaaaa     3900

accaccacca tcaccagaca ggtgcgaaag gatgaaagtg accatgtttt gtttacggtt     3960

ttccaggttt aagctgttac tgtcttcagt aagccgtgat tttcattgct gggcttgtct     4020

gtagatttta gaccctattg ctgcttgagg caactcatct taggttggca aaaaggcagg     4080

atggccgggc gcggtggctc acgcctgtaa tcctagcact ttgggaggcc aaggtgggag     4140

gattgcttga gctcaggagt ttgagaccaa cctggg                               4176


<210>  24
<211>  4082
<212>  DNA
<213>  homo sapiens

<400>  24
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt       60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac      120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc      180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag      240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct      300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc      360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg      420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg      480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc      540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca      600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg      660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt      720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg      780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg      840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga      900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct      960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg     1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc     1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca     1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc     1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc     1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc     1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt     1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta     1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc     1500

caggttcaag aagacgtgga agctgcgggc tctgaaggaa ggcaagacaa gcatgcatcc     1560

gccgtactct ttggggcagc tggtcccgga gaggcctcga cccaccccag tgcttgttcc     1620

tctcatctcc ccaccggtgt cccccagcag cctggggtct gacaatacct cgagccacaa     1680

ccgaccagat gccagggacc cacggagccc ttatgacatc agcaatacag actacttctt     1740

ccccagatag ctggctgggt ggcaccagca gcctggaccc tgtggatgat aaaacacaaa     1800

cgggctcagc aaaagatgct tctcactgcc atgccagctt atctcagggg tgtgcggcct     1860

ttggcttcac ggaagagcct tgcggaaggt tctacgccag gggaaaatca gcctgctcca     1920

gctgttcagc tggttgaggt ttcaaacctc cctttccaaa tgcccagctt aaaggggcta     1980

gagtgaactt gggccactgt gaagagaacc atatcaagac tctttggaca ctcacacgga     2040

cactcaaaag ctgggcaggt tggtgggggc ctcggtgtgg agaagcggct ggcagcccac     2100

ccctcaacac ctctgcacaa gctgcaccct caggcaggtg ggatggattt ccagccaaag     2160

cctcctccag ccgccatgct cctggcccac tgcatcgttt catcttccaa ctcaaactct     2220

taaaacccaa gtgccttagc aaattctgtt tttctaggcc tggggacggc ttttacttaa     2280

accgccaagg ctgggggaag aagctctctc ctccctttct tccctacagt tgaaaaacag     2340

ctgagggtga gtgggtgaat aatacagtat ctcagggcct ggtcgttttc aacagaatta     2400

taattagttc ctcattagca ttttgctaaa tgtgaatgat gatcctaggc atttgctgaa     2460

tacagaggca actgcattgg ctttgggttg caggacctca ggtgagaagc agaggaagga     2520

gaggagaggg gcacagggtc tctaccatcc cctgtagagt gggagctgag tgggggatca     2580

cagcctctga aaaccaatgt tctctcttct ccacctccca caaaggagag ctagcagcag     2640

ggagggcttc tgccatttct gagatcaaaa cggttttact gcagctttgt ttgttgtcag     2700

ctgaacctgg gtaactaggg aagataatat taaggaagac aatgtgaaaa gaaaaatgag     2760

cctggcaaga atgtgtttaa acttggtttt taaaaaactg ctgactgttt tctcttgaga     2820

gggtggaata tccaatattc gctgtgtcag catagaagta acttacttag gtgtggggga     2880

agcaccataa ctttgtttag cccaaaacca agtcaagtga aaaaggagga agagaaaaaa     2940

tattttcctg ccaggcatgg tggcccacgc acttcgggag gtcgaggcag gaggatcact     3000

tgagtccaga agtttgagat cagcctgggc aatgtgataa aaccccatct ctacaaaaag     3060

cataaaaatt agccaagtgt ggtagagtgt gcctgaagtc ccagatactt ggggggctga     3120

ggtgggagga tctcttgagc ctgggaggtc aaggctgcag tgagccgaga ttgcaccact     3180

gcactccagc ctgggtgaca gagcaagtga gaccctgtct caaaaaaaga aaaagaaaaa     3240

gaaaaaatat tttccctatt agagaagaga ttgtggtttc attctgtatt ttgtttttgt     3300

cttaaaaagt ggaaaaatag cctgcctctt ctctactcta gggaaaaacc agcgtgtgac     3360

tactccccca ggtggttatg gagagggtgt ccggtccctg tcccagtgcc gagaaggaag     3420

cctcccacga ctgcccggca gggtcctaga aattccccac cctgaaagcc ctgagctttc     3480

tgctatcaaa gaggttttaa aaaaatccca tttaaaaaaa atcccttacc tcggtgcctt     3540

cctcttttta tttagttcct tgagttgatt cagctctgca agaattgaag caggactaaa     3600

tgtctagttg taacaccatg attaaccact tcagctgact tttctgtccg agctttgaaa     3660

attcagtggt gttagtggtt acccagttag ctctcaagtt atcagggtat tccagagtgg     3720

ggatatgatt taaatcagcc gtgtaaccat ggacccaata tttaccagac cacaaaactt     3780

ttctaatact ctaccctctt agaaaaacca ccaccatcac cagacaggtg cgaaaggatg     3840

aaagtgacca tgttttgttt acggttttcc aggtttaagc tgttactgtc ttcagtaagc     3900

cgtgattttc attgctgggc ttgtctgtag attttagacc ctattgctgc ttgaggcaac     3960

tcatcttagg ttggcaaaaa ggcaggatgg ccgggcgcgg tggctcacgc ctgtaatcct     4020

agcactttgg gaggccaagg tgggaggatt gcttgagctc aggagtttga gaccaacctg     4080

gg                                                                    4082


<210>  25
<211>  4370
<212>  DNA
<213>  homo sapiens

<400>  25
ccgcgctctc tgatcagagg cgaagctcgg aggtcctaca ggtatggatc tctggcagct       60

gctgttgacc ttggcactgg caggatcaag tgatgctttt tctggaagtg aggccacagc      120

agctatcctt agcagagcac cctggagtct gcaaagtgtt aatccaggcc taaagacaaa      180

ttcttctaag gagcctaaat tcaccaagtg ccgttcacct gagcgagaga ctttttcatg      240

ccactggaca gatgaggttc atcatggtac aaagaaccta ggacccatac agctgttcta      300

taccagaagg aacactcaag aatggactca agaatggaaa gaatgccctg attatgtttc      360

tgctggggaa aacagctgtt actttaattc atcgtttacc tccatctgga taccttattg      420

tatcaagcta actagcaatg gtggtacagt ggatgaaaag tgtttctctg ttgatgaaat      480

agtgcaacca gatccaccca ttgccctcaa ctggacttta ctgaacgtca gtttaactgg      540

gattcatgca gatatccaag tgagatggga agcaccacgc aatgcagata ttcagaaagg      600

atggatggtt ctggagtatg aacttcaata caaagaagta aatgaaacta aatggaaaat      660

gatggaccct atattgacaa catcagttcc agtgtactca ttgaaagtgg ataaggaata      720

tgaagtgcgt gtgagatcca aacaacgaaa ctctggaaat tatggcgagt tcagtgaggt      780

gctctatgta acacttcctc agatgagcca atttacatgt gaagaagatt tctactttcc      840

atggctctta attattatct ttggaatatt tgggctaaca gtgatgctat ttgtattctt      900

attttctaaa cagcaaagga ttaaaatgct gattctgccc ccagttccag ttccaaagat      960

taaaggaatc gatccagatc tcctcaagga aggaaaatta gaggaggtga acacaatctt     1020

agccattcat gatagctata aacccgaatt ccacagtgat gactcttggg ttgaatttat     1080

tgagctagat attgatgagc cagatgaaaa gactgaggaa tcagacacag acagacttct     1140

aagcagtgac catgagaaat cacatagtaa cctaggggtg aaggatggcg actctggacg     1200

taccagctgt tgtgaacctg acattctgga gactgatttc aatgccaatg acatacatga     1260

gggtacctca gaggttgctc agccacagag gttaaaaggg gaagcagatc tcttatgcct     1320

tgaccagaag aatcaaaata actcacctta tcatgatgct tgccctgcta ctcagcagcc     1380

cagtgttatc caagcagaga aaaacaaacc acaaccactt cctactgaag gagctgagtc     1440

aactcaccaa gctgcccata ttcagctaag caatccaagt tcactgtcaa acatcgactt     1500

ttatgcccag gtgagcgaca ttacaccagc aggtagtgtg gtcctttccc cgggccaaaa     1560

gaataaggca gggatgtccc aatgtgacat gcacccggaa atggtctcac tctgccaaga     1620

aaacttcctt atggacaatg cctacttctg tgaggcagat gccaaaaagt gcatccctgt     1680

ggctcctcac atcaaggttg aatcacacat acagccaagc ttaaaccaag aggacattta     1740

catcaccaca gaaagcctta ccactgctgc tgggaggcct gggacaggag aacatgttcc     1800

aggttctgag atgcctgtcc cagactatac ctccattcat atagtacagt ccccacaggg     1860

cctcatactc aatgcgactg ccttgccctt gcctgacaaa gagtttctct catcatgtgg     1920

ctatgtgagc acagaccaac tgaacaaaat catgccttag cctttctttg gtttcccaag     1980

agctacgtat ttaatagcaa agaattgact ggggcaataa cgtttaagcc aaaacaatgt     2040

ttaaaccttt tttgggggag tgacaggatg gggtatggat tctaaaatgc cttttcccaa     2100

aatgttgaaa tatgatgtta aaaaaataag aagaatgctt aatcagatag atattcctat     2160

tgtgcaatgt aaatatttta aagaattgtg tcagactgtt tagtagcagt gattgtctta     2220

atattgtggg tgttaatttt tgatactaag cattgaatgg ctatgttttt aatgtatagt     2280

aaatcacgct ttttgaaaaa gcgaaaaaat caggtggctt ttgcggttca ggaaaattga     2340

atgcaaacca tagcacaggc taattttttg ttgtttctta aataagaaac ttttttattt     2400

aaaaaactaa aaactagagg tgagaaattt aaactataag caagaaggca aaaatagttt     2460

ggatatgtaa aacatttatt ttgacataaa gttgataaag attttttaat aatttagact     2520

tcaagcatgg ctattttata ttacactaca cactgtgtac tgcagttggt atgacccctc     2580

taaggagtgt agcaactaca gtctaaagct ggtttaatgt tttggccaat gcacctaaag     2640

aaaaacaaac tcgtttttta caaagccctt ttatacctcc ccagactcct tcaacaattc     2700

taaaatgatt gtagtaatct gcattattgg aatataattg ttttatctga atttttaaac     2760

aagtatttgt taatttagaa aactttaaag cgtttgcaca gatcaactta ccaggcacca     2820

aaagaagtaa aagcaaaaaa gaaaaccttt cttcaccaaa tcttggttga tgccaaaaaa     2880

aaatacatgc taagagaagt agaaatcata gctggttcac actgaccaag atacttaagt     2940

gctgcaattg cacgcggagt gagtttttta gtgcgtgcag atggtgagag ataagatcta     3000

tagcctctgc agcggaatct gttcacaccc aacttggttt tgctacataa ttatccagga     3060

agggaataag gtacaagaag cattttgtaa gttgaagcaa atcgaatgaa attaactggg     3120

taatgaaaca aagagttcaa gaaataagtt tttgtttcac agcctataac cagacacata     3180

ctcatttttc atgataatga acagaacata gacagaagaa acaaggtttt cagtccccac     3240

agataactga aaattattta aaccgctaaa agaaactttc tttctcacta aatcttttat     3300

aggatttatt taaaatagca aaagaagaag tttcatcatt ttttacttcc tctctgagtg     3360

gactggcctc aaagcaagca ttcagaagaa aaagaagcaa cctcagtaat ttagaaatca     3420

ttttgcaatc ccttaatatc ctaaacatca ttcatttttg ttgttgttgt tgttgttgag     3480

acagagtctc gctctgtcgc caggctagag tgcggtggcg cgatcttgac tcactgcaat     3540

ctccacctcc cacaggttca ggcgattccc gtgcctcagc ctcctgagta gctgggacta     3600

caggcacgca ccaccatgcc aggctaattt ttttgtattt tagcagagac ggggtttcac     3660

catgttggcc aggatggtct cgatctcctg acctcgtgat ccacccgact cggcctccca     3720

aagtgctggg attacaggtg taagccaccg tgcccagccc taaacatcat tcttgagagc     3780

attgggatat ctcctgaaaa ggtttatgaa aaagaagaat ctcatctcag tgaagaatac     3840

ttctcatttt ttaaaaaagc ttaaaacttt gaagttagct ttaacttaaa tagtatttcc     3900

catttatcgc agaccttttt taggaagcaa gcttaatggc tgataatttt aaattctctc     3960

tcttgcagga aggactatga aaagctagaa ttgagtgttt aaagttcaac atgttatttg     4020

taatagatgt ttgatagatt ttctgctact ttgctgctat ggttttctcc aagagctaca     4080

taatttagtt tcatataaag tatcatcagt gtagaaccta attcaattca aagctgtgtg     4140

tttggaagac tatcttacta tttcacaaca gcctgacaac atttctatag ccaaaaatag     4200

ctaaatacct caatcagtct cagaatgtca ttttggtact ttggtggcca cataagccat     4260

tattcactag tatgactagt tgtgtctggc agtttatatt taactctctt tatgtctgtg     4320

gattttttcc ttcaaagttt aataaattta ttttcttgga aaaaaaaaaa                4370


<210>  26
<211>  1518
<212>  DNA
<213>  homo sapiens

<400>  26
aaaacagccc ggagcctgca gcccagcccc acccagaccc atggctggac ctgccaccca       60

gagccccatg aagctgatgg ccctgcagct gctgctgtgg cacagtgcac tctggacagt      120

gcaggaagcc acccccctgg gccctgccag ctccctgccc cagagcttcc tgctcaagtg      180

cttagagcaa gtgaggaaga tccagggcga tggcgcagcg ctccaggaga agctggtgag      240

tgagtgtgcc acctacaagc tgtgccaccc cgaggagctg gtgctgctcg gacactctct      300

gggcatcccc tgggctcccc tgagcagctg ccccagccag gccctgcagc tggcaggctg      360

cttgagccaa ctccatagcg gccttttcct ctaccagggg ctcctgcagg ccctggaagg      420

gatctccccc gagttgggtc ccaccttgga cacactgcag ctggacgtcg ccgactttgc      480

caccaccatc tggcagcaga tggaagaact gggaatggcc cctgccctgc agcccaccca      540

gggtgccatg ccggccttcg cctctgcttt ccagcgccgg gcaggagggg tcctggttgc      600

ctcccatctg cagagcttcc tggaggtgtc gtaccgcgtt ctacgccacc ttgcccagcc      660

ctgagccaag ccctccccat cccatgtatt tatctctatt taatatttat gtctatttaa      720

gcctcatatt taaagacagg gaagagcaga acggagcccc aggcctctgt gtccttccct      780

gcatttctga gtttcattct cctgcctgta gcagtgagaa aaagctcctg tcctcccatc      840

ccctggactg ggaggtagat aggtaaatac caagtattta ttactatgac tgctccccag      900

ccctggctct gcaatgggca ctgggatgag ccgctgtgag cccctggtcc tgagggtccc      960

cacctgggac ccttgagagt atcaggtctc ccacgtggga gacaagaaat ccctgtttaa     1020

tatttaaaca gcagtgttcc ccatctgggt ccttgcaccc ctcactctgg cctcagccga     1080

ctgcacagcg gcccctgcat ccccttggct gtgaggcccc tggacaagca gaggtggcca     1140

gagctgggag gcatggccct ggggtcccac gaatttgctg gggaatctcg tttttcttct     1200

taagactttt gggacatggt ttgactcccg aacatcaccg acgtgtctcc tgtttttctg     1260

ggtggcctcg ggacacctgc cctgccccca cgagggtcag gactgtgact ctttttaggg     1320

ccaggcaggt gcctggacat ttgccttgct ggacggggac tggggatgtg ggagggagca     1380

gacaggagga atcatgtcag gcctgtgtgt gaaaggaagc tccactgtca ccctccacct     1440

cttcaccccc cactcaccag tgtcccctcc actgtcacat tgtaactgaa cttcaggata     1500

ataaagtgtt tgcctcca                                                   1518


<210>  27
<211>  1509
<212>  DNA
<213>  homo sapiens

<400>  27
aaaacagccc ggagcctgca gcccagcccc acccagaccc atggctggac ctgccaccca       60

gagccccatg aagctgatgg ccctgcagct gctgctgtgg cacagtgcac tctggacagt      120

gcaggaagcc acccccctgg gccctgccag ctccctgccc cagagcttcc tgctcaagtg      180

cttagagcaa gtgaggaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc      240

cacctacaag ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc      300

ctgggctccc ctgagcagct gccccagcca ggccctgcag ctggcaggct gcttgagcca      360

actccatagc ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatctcccc      420

cgagttgggt cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat      480

ctggcagcag atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat      540

gccggccttc gcctctgctt tccagcgccg ggcaggaggg gtcctggttg cctcccatct      600

gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac cttgcccagc cctgagccaa      660

gccctcccca tcccatgtat ttatctctat ttaatattta tgtctattta agcctcatat      720

ttaaagacag ggaagagcag aacggagccc caggcctctg tgtccttccc tgcatttctg      780

agtttcattc tcctgcctgt agcagtgaga aaaagctcct gtcctcccat cccctggact      840

gggaggtaga taggtaaata ccaagtattt attactatga ctgctcccca gccctggctc      900

tgcaatgggc actgggatga gccgctgtga gcccctggtc ctgagggtcc ccacctggga      960

cccttgagag tatcaggtct cccacgtggg agacaagaaa tccctgttta atatttaaac     1020

agcagtgttc cccatctggg tccttgcacc cctcactctg gcctcagccg actgcacagc     1080

ggcccctgca tccccttggc tgtgaggccc ctggacaagc agaggtggcc agagctggga     1140

ggcatggccc tggggtccca cgaatttgct ggggaatctc gtttttcttc ttaagacttt     1200

tgggacatgg tttgactccc gaacatcacc gacgtgtctc ctgtttttct gggtggcctc     1260

gggacacctg ccctgccccc acgagggtca ggactgtgac tctttttagg gccaggcagg     1320

tgcctggaca tttgccttgc tggacgggga ctggggatgt gggagggagc agacaggagg     1380

aatcatgtca ggcctgtgtg tgaaaggaag ctccactgtc accctccacc tcttcacccc     1440

ccactcacca gtgtcccctc cactgtcaca ttgtaactga acttcaggat aataaagtgt     1500

ttgcctcca                                                             1509


<210>  28
<211>  1703
<212>  DNA
<213>  homo sapiens

<400>  28
aaaacagccc ggagcctgca gcccagcccc acccagaccc atggctggac ctgccaccca       60

gagccccatg aagctgatgg gtgagtgtct tggcccagga tgggagagcc gcctgccctg      120

gcatgggagg gaggctggtg tgacagaggg gctggggatc cccgttctgg gaatggggat      180

taaaggcacc cagtgtcccc gagagggcct caggtggtag ggaacagcat gtctcctgag      240

cccgctctgt ccccagccct gcagctgctg ctgtggcaca gtgcactctg gacagtgcag      300

gaagccaccc ccctgggccc tgccagctcc ctgccccaga gcttcctgct caagtgctta      360

gagcaagtga ggaagatcca gggcgatggc gcagcgctcc aggagaagct gtgtgccacc      420

tacaagctgt gccaccccga ggagctggtg ctgctcggac actctctggg catcccctgg      480

gctcccctga gcagctgccc cagccaggcc ctgcagctgg caggctgctt gagccaactc      540

catagcggcc ttttcctcta ccaggggctc ctgcaggccc tggaagggat ctcccccgag      600

ttgggtccca ccttggacac actgcagctg gacgtcgccg actttgccac caccatctgg      660

cagcagatgg aagaactggg aatggcccct gccctgcagc ccacccaggg tgccatgccg      720

gccttcgcct ctgctttcca gcgccgggca ggaggggtcc tggttgcctc ccatctgcag      780

agcttcctgg aggtgtcgta ccgcgttcta cgccaccttg cccagccctg agccaagccc      840

tccccatccc atgtatttat ctctatttaa tatttatgtc tatttaagcc tcatatttaa      900

agacagggaa gagcagaacg gagccccagg cctctgtgtc cttccctgca tttctgagtt      960

tcattctcct gcctgtagca gtgagaaaaa gctcctgtcc tcccatcccc tggactggga     1020

ggtagatagg taaataccaa gtatttatta ctatgactgc tccccagccc tggctctgca     1080

atgggcactg ggatgagccg ctgtgagccc ctggtcctga gggtccccac ctgggaccct     1140

tgagagtatc aggtctccca cgtgggagac aagaaatccc tgtttaatat ttaaacagca     1200

gtgttcccca tctgggtcct tgcacccctc actctggcct cagccgactg cacagcggcc     1260

cctgcatccc cttggctgtg aggcccctgg acaagcagag gtggccagag ctgggaggca     1320

tggccctggg gtcccacgaa tttgctgggg aatctcgttt ttcttcttaa gacttttggg     1380

acatggtttg actcccgaac atcaccgacg tgtctcctgt ttttctgggt ggcctcggga     1440

cacctgccct gcccccacga gggtcaggac tgtgactctt tttagggcca ggcaggtgcc     1500

tggacatttg ccttgctgga cggggactgg ggatgtggga gggagcagac aggaggaatc     1560

atgtcaggcc tgtgtgtgaa aggaagctcc actgtcaccc tccacctctt caccccccac     1620

tcaccagtgt cccctccact gtcacattgt aactgaactt caggataata aagtgtttgc     1680

ctccaaaaaa aaaaaaaaaa aaa                                             1703


<210>  29
<211>  2165
<212>  DNA
<213>  homo sapiens

<400>  29
ctgagcgaca gcaagtgcag cgggctccta ccccgggtga ggggtggcct ccgcgtggga       60

tcgtgccctc ttcagcccgc tcctgtcccc gacatcacgt gtattccgca cgtcccctcc      120

gcgctgtgtg tctactgaga cggggaggcg tgacagggcc cgggtccctt ctcagtggtg      180

ctctgtgctt cagggcaagc tccccgtctc cgggcgcact tccctcgcct gtgttcggtc      240

catcctcctt tctccagcct cctcccctcg caggtgggat cgtcggtggg accggagcgc      300

gggcgggcgc ggccccccgg gaccatggcc gggtccgaca ccgcgccctt cctcagccag      360

gcggatgacc cggacgacgg gccagtgcct ggcaccccgg ggttgccagg gtccacgggg      420

aacccgaagt ccgaggagcc cgaggtcccg gaccaggagg ggctgcagcg catcaccggc      480

ctgtctcccg gccgttcggc tctcatagtg gcggtgctgt gctacatcaa tctcctgaac      540

tacatggacc gcttcaccgt ggctggcgtc cttcccgaca tcgagcagtt cttcaacatc      600

ggggacagta gctctgggct catccagacc gtgttcatct ccagttacat ggtgttggca      660

cctgtgtttg gctacctggg tgacaggtac aatcggaagt atctcatgtg cgggggcatt      720

gccttctggt ccctggtgac actggggtca tccttcatcc ccggagagca tttctggctg      780

ctcctcctga cccggggcct ggtgggggtc ggggaggcca gttattccac catcgcgccc      840

actctcattg ccgacctctt tgtggccgac cagcggagcc ggatgctcag catcttctac      900

tttgccattc cggtgggcag tggtctgggc tacattgcag gctccaaagt gaaggatatg      960

gctggagact ggcactgggc tctgagggtg acaccgggtc taggagtggt ggccgttctg     1020

ctgctgttcc tggtagtgcg ggagccgcca aggggagccg tggagcgcca ctcagatttg     1080

ccacccctga accccacctc gtggtgggca gatctgaggg ctctggcaag aaatcctagt     1140

ttcgtcctgt cttccctggg cttcactgct gtggcctttg tcacgggctc cctggctctg     1200

tgggctccgg cattcctgct gcgttcccgc gtggtccttg gggagacccc accctgcctt     1260

cccggagact cctgctcttc ctctgacagt ctcatctttg gactcatcac ctgcctgacc     1320

ggagtcctgg gtgtgggcct gggtgtggag atcagccgcc ggctccgcca ctccaacccc     1380

cgggctgatc ccctggtctg tgccactggc ctcctgggct ctgcaccctt cctcttcctg     1440

tcccttgcct gcgcccgtgg tagcatcgtg gccacttata ttttcatctt cattggagag     1500

accctcctgt ccatgaactg ggccatcgtg gccgacattc tgctgtacgt ggtgatccct     1560

acccgacgct ccaccgccga ggccttccag atcgtgctgt cccacctgct gggtgatgct     1620

gggagcccct acctcattgg cctgatctct gaccgcctgc gccggaactg gcccccctcc     1680

ttcttgtccg agttccgggc tctgcagttc tcgctcatgc tctgcgcgtt tgttggggca     1740

ctgggcggcg cagccttcct gggcaccgcc atcttcattg aggccgaccg ccggcgggca     1800

cagctgcacg tgcagggcct gctgcacgaa gcagggtcca cagacgaccg gattgtggtg     1860

ccccagcggg gccgctccac ccgcgtgccc gtggccagtg tgctcatctg agaggctgcc     1920

gctcacctac ctgcacatct gccacagctg gccctgggcc caccccacga agggcctggg     1980

cctaacccct tggcctggcc cagcttccag agggaccctg ggccgtgtgc cagctcccag     2040

acactacatg ggtagctcag gggaggaggt gggggtccag gagggggatc cctctccaca     2100

ggggcagccc caagggctcg gtgctatttg taacggaata aaatttgtgc cagaaaaaaa     2160

aaaaa                                                                 2165


<210>  30
<211>  240
<212>  PRT
<213>  homo sapiens

<400>  30

Met Val Gly Gln Arg Val Leu Leu Leu Val Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Val Leu Leu Ser Glu Ala Ala Lys Ile Leu Thr Ile Ser Thr Leu Gly 
            20                  25                  30          


Gly Ser His Tyr Leu Leu Leu Asp Arg Val Ser Gln Ile Leu Gln Glu 
        35                  40                  45              


His Gly His Asn Val Thr Met Leu His Gln Ser Gly Lys Phe Leu Ile 
    50                  55                  60                  


Pro Asp Ile Lys Glu Glu Glu Lys Ser Tyr Gln Val Ile Arg Trp Phe 
65                  70                  75                  80  


Ser Pro Glu Asp His Gln Lys Arg Ile Lys Lys His Phe Asp Ser Tyr 
                85                  90                  95      


Ile Glu Thr Ala Leu Asp Gly Arg Lys Glu Ser Glu Ala Leu Val Lys 
            100                 105                 110         


Leu Met Glu Ile Phe Gly Thr Gln Cys Ser Tyr Leu Leu Ser Arg Lys 
        115                 120                 125             


Asp Ile Met Asp Ser Leu Lys Asn Glu Asn Cys Asp Leu Val Phe Val 
    130                 135                 140                 


Glu Ala Phe Asp Phe Cys Ser Phe Leu Ile Ala Glu Lys Leu Val Lys 
145                 150                 155                 160 


Pro Phe Val Ala Ile Leu Pro Thr Thr Phe Gly Ser Leu Asp Phe Gly 
                165                 170                 175     


Leu Pro Ser Pro Leu Ser Tyr Val Pro Val Phe Pro Ser Leu Leu Thr 
            180                 185                 190         


Asp His Met Asp Phe Trp Gly Arg Val Lys Asn Phe Leu Met Phe Phe 
        195                 200                 205             


Ser Phe Ser Arg Ser Gln Trp Asp Met Gln Ser Thr Phe Asp Asn Thr 
    210                 215                 220                 


Ile Lys Glu His Phe Pro Glu Gly Ser Arg Pro Val Leu Ser His Leu 
225                 230                 235                 240 


<210>  31
<211>  523
<212>  PRT
<213>  homo sapiens

<400>  31

Met Ala Gly Gln Arg Val Leu Leu Leu Val Gly Phe Leu Leu Pro Gly 
1               5                   10                  15      


Val Leu Leu Ser Glu Ala Ala Lys Ile Leu Thr Ile Ser Thr Val Gly 
            20                  25                  30          


Gly Ser His Tyr Leu Leu Met Asp Arg Val Ser Gln Ile Leu Gln Asp 
        35                  40                  45              


His Gly His Asn Val Thr Met Leu Asn His Lys Arg Gly Pro Phe Met 
    50                  55                  60                  


Pro Asp Phe Lys Lys Glu Glu Lys Ser Tyr Gln Val Ile Ser Trp Leu 
65                  70                  75                  80  


Ala Pro Glu Asp His Gln Arg Glu Phe Lys Lys Ser Phe Asp Phe Phe 
                85                  90                  95      


Leu Glu Glu Thr Leu Gly Gly Arg Gly Lys Phe Glu Asn Leu Leu Asn 
            100                 105                 110         


Val Leu Glu Tyr Leu Ala Leu Gln Cys Ser His Phe Leu Asn Arg Lys 
        115                 120                 125             


Asp Ile Met Asp Ser Leu Lys Asn Glu Asn Phe Asp Met Val Ile Val 
    130                 135                 140                 


Glu Thr Phe Asp Tyr Cys Pro Phe Leu Ile Ala Glu Lys Leu Gly Lys 
145                 150                 155                 160 


Pro Phe Val Ala Ile Leu Ser Thr Ser Phe Gly Ser Leu Glu Phe Gly 
                165                 170                 175     


Leu Pro Ile Pro Leu Ser Tyr Val Pro Val Phe Arg Ser Leu Leu Thr 
            180                 185                 190         


Asp His Met Asp Phe Trp Gly Arg Val Lys Asn Phe Leu Met Phe Phe 
        195                 200                 205             


Ser Phe Cys Arg Arg Gln Gln His Met Gln Ser Thr Phe Asp Asn Thr 
    210                 215                 220                 


Ile Lys Glu His Phe Thr Glu Gly Ser Arg Pro Val Leu Ser His Leu 
225                 230                 235                 240 


Leu Leu Lys Ala Glu Leu Trp Phe Ile Asn Ser Asp Phe Ala Phe Asp 
                245                 250                 255     


Phe Ala Arg Pro Leu Leu Pro Asn Thr Val Tyr Val Gly Gly Leu Met 
            260                 265                 270         


Glu Lys Pro Ile Lys Pro Val Pro Gln Asp Leu Glu Asn Phe Ile Ala 
        275                 280                 285             


Lys Phe Glu Asp Ser Gly Phe Val Leu Val Thr Leu Gly Ser Met Val 
    290                 295                 300                 


Asn Thr Cys Gln Asn Pro Glu Ile Phe Lys Glu Met Asn Asn Ala Phe 
305                 310                 315                 320 


Ala His Leu Pro Gln Gly Val Ile Trp Lys Cys Gln Cys Ser His Trp 
                325                 330                 335     


Pro Lys Asp Val His Leu Ala Ala Asn Val Lys Ile Val Asp Trp Leu 
            340                 345                 350         


Pro Gln Ser Asp Leu Leu Ala His Pro Ser Ile Arg Leu Phe Val Thr 
        355                 360                 365             


His Gly Gly Gln Asn Ser Ile Met Glu Ala Ile Gln His Gly Val Pro 
    370                 375                 380                 


Met Val Gly Ile Pro Leu Phe Gly Asp Gln Pro Glu Asn Met Val Arg 
385                 390                 395                 400 


Val Glu Ala Lys Lys Phe Gly Val Ser Ile Gln Leu Lys Lys Leu Lys 
                405                 410                 415     


Ala Glu Thr Leu Ala Leu Lys Met Lys Gln Ile Met Glu Asp Lys Arg 
            420                 425                 430         


Tyr Lys Ser Ala Ala Val Ala Ala Ser Val Ile Leu Arg Ser His Pro 
        435                 440                 445             


Leu Ser Pro Thr Gln Arg Leu Val Gly Trp Ile Asp His Val Leu Gln 
    450                 455                 460                 


Thr Gly Gly Ala Thr His Leu Lys Pro Tyr Val Phe Gln Gln Pro Trp 
465                 470                 475                 480 


His Glu Gln Tyr Leu Leu Asp Val Phe Val Phe Leu Leu Gly Leu Thr 
                485                 490                 495     


Leu Gly Thr Leu Trp Leu Cys Gly Lys Leu Leu Gly Met Ala Val Trp 
            500                 505                 510         


Trp Leu Arg Gly Ala Arg Lys Val Lys Glu Thr 
        515                 520             


<210>  32
<211>  533
<212>  PRT
<213>  homo sapiens

<400>  32

Met Ala Phe Ala Asn Leu Arg Lys Val Leu Ile Ser Asp Ser Leu Asp 
1               5                   10                  15      


Pro Cys Cys Arg Lys Ile Leu Gln Asp Gly Gly Leu Gln Val Val Glu 
            20                  25                  30          


Lys Gln Asn Leu Ser Lys Glu Glu Leu Ile Ala Glu Leu Gln Asp Cys 
        35                  40                  45              


Glu Gly Leu Ile Val Arg Ser Ala Thr Lys Val Thr Ala Asp Val Ile 
    50                  55                  60                  


Asn Ala Ala Glu Lys Leu Gln Val Val Gly Arg Ala Gly Thr Gly Val 
65                  70                  75                  80  


Asp Asn Val Asp Leu Glu Ala Ala Thr Arg Lys Gly Ile Leu Val Met 
                85                  90                  95      


Asn Thr Pro Asn Gly Asn Ser Leu Ser Ala Ala Glu Leu Thr Cys Gly 
            100                 105                 110         


Met Ile Met Cys Leu Ala Arg Gln Ile Pro Gln Ala Thr Ala Ser Met 
        115                 120                 125             


Lys Asp Gly Lys Trp Glu Arg Lys Lys Phe Met Gly Thr Glu Leu Asn 
    130                 135                 140                 


Gly Lys Thr Leu Gly Ile Leu Gly Leu Gly Arg Ile Gly Arg Glu Val 
145                 150                 155                 160 


Ala Thr Arg Met Gln Ser Phe Gly Met Lys Thr Ile Gly Tyr Asp Pro 
                165                 170                 175     


Ile Ile Ser Pro Glu Val Ser Ala Ser Phe Gly Val Gln Gln Leu Pro 
            180                 185                 190         


Leu Glu Glu Ile Trp Pro Leu Cys Asp Phe Ile Thr Val His Thr Pro 
        195                 200                 205             


Leu Leu Pro Ser Thr Thr Gly Leu Leu Asn Asp Asn Thr Phe Ala Gln 
    210                 215                 220                 


Cys Lys Lys Gly Val Arg Val Val Asn Cys Ala Arg Gly Gly Ile Val 
225                 230                 235                 240 


Asp Glu Gly Ala Leu Leu Arg Ala Leu Gln Ser Gly Gln Cys Ala Gly 
                245                 250                 255     


Ala Ala Leu Asp Val Phe Thr Glu Glu Pro Pro Arg Asp Arg Ala Leu 
            260                 265                 270         


Val Asp His Glu Asn Val Ile Ser Cys Pro His Leu Gly Ala Ser Thr 
        275                 280                 285             


Lys Glu Ala Gln Ser Arg Cys Gly Glu Glu Ile Ala Val Gln Phe Val 
    290                 295                 300                 


Asp Met Val Lys Gly Lys Ser Leu Thr Gly Val Val Asn Ala Gln Ala 
305                 310                 315                 320 


Leu Thr Ser Ala Phe Ser Pro His Thr Lys Pro Trp Ile Gly Leu Ala 
                325                 330                 335     


Glu Ala Leu Gly Thr Leu Met Arg Ala Trp Ala Gly Ser Pro Lys Gly 
            340                 345                 350         


Thr Ile Gln Val Ile Thr Gln Gly Thr Ser Leu Lys Asn Ala Gly Asn 
        355                 360                 365             


Cys Leu Ser Pro Ala Val Ile Val Gly Leu Leu Lys Glu Ala Ser Lys 
    370                 375                 380                 


Gln Ala Asp Val Asn Leu Val Asn Ala Lys Leu Leu Val Lys Glu Ala 
385                 390                 395                 400 


Gly Leu Asn Val Thr Thr Ser His Ser Pro Ala Ala Pro Gly Glu Gln 
                405                 410                 415     


Gly Phe Gly Glu Cys Leu Leu Ala Val Ala Leu Ala Gly Ala Pro Tyr 
            420                 425                 430         


Gln Ala Val Gly Leu Val Gln Gly Thr Thr Pro Val Leu Gln Gly Leu 
        435                 440                 445             


Asn Gly Ala Val Phe Arg Pro Glu Val Pro Leu Arg Arg Asp Leu Pro 
    450                 455                 460                 


Leu Leu Leu Phe Arg Thr Gln Thr Ser Asp Pro Ala Met Leu Pro Thr 
465                 470                 475                 480 


Met Ile Gly Leu Leu Ala Glu Ala Gly Val Arg Leu Leu Ser Tyr Gln 
                485                 490                 495     


Thr Ser Leu Val Ser Asp Gly Glu Thr Trp His Val Met Gly Ile Ser 
            500                 505                 510         


Ser Leu Leu Pro Ser Leu Glu Ala Trp Lys Gln His Val Thr Glu Ala 
        515                 520                 525             


Phe Gln Phe His Phe 
    530             


<210>  33
<211>  372
<212>  PRT
<213>  homo sapiens

<400>  33

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 
                245                 250                 255     


Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 
            260                 265                 270         


Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 
        275                 280                 285             


Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 
    290                 295                 300                 


Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 
305                 310                 315                 320 


Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 
                325                 330                 335     


Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 
            340                 345                 350         


Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys Gly Asn Gln 
        355                 360                 365             


Thr Gln Ile Tyr 
    370         


<210>  34
<211>  177
<212>  PRT
<213>  homo sapiens

<400>  34

Met Ala Val Ala Asn Ser Ser Pro Val Asn Pro Val Val Phe Phe Asp 
1               5                   10                  15      


Val Ser Ile Gly Gly Gln Glu Val Gly Arg Met Lys Ile Glu Leu Phe 
            20                  25                  30          


Ala Asp Val Val Pro Lys Thr Ala Glu Asn Phe Arg Gln Phe Cys Thr 
        35                  40                  45              


Gly Glu Phe Arg Lys Asp Gly Val Pro Ile Gly Tyr Lys Gly Ser Thr 
    50                  55                  60                  


Phe His Arg Val Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Val 
65                  70                  75                  80  


Asn Gly Asp Gly Thr Gly Val Ala Ser Ile Tyr Arg Gly Pro Phe Ala 
                85                  90                  95      


Asp Glu Asn Phe Lys Leu Arg His Ser Ala Pro Gly Leu Leu Ser Met 
            100                 105                 110         


Ala Asn Ser Gly Pro Ser Thr Asn Gly Cys Gln Phe Phe Ile Thr Cys 
        115                 120                 125             


Ser Lys Cys Asp Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Ile 
    130                 135                 140                 


Ile Asp Gly Leu Leu Val Met Arg Lys Ile Glu Asn Val Pro Thr Gly 
145                 150                 155                 160 


Pro Asn Asn Lys Pro Lys Leu Pro Val Val Ile Ser Gln Cys Gly Glu 
                165                 170                 175     


Met 
    


<210>  35
<211>  3312
<212>  PRT
<213>  homo sapiens

<400>  35

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  36
<211>  297
<212>  PRT
<213>  homo sapiens

<400>  36

Met Lys His Ile Ile Asn Ser Tyr Glu Asn Ile Asn Asn Thr Ala Arg 
1               5                   10                  15      


Asn Asn Ser Asp Cys Pro Arg Val Val Leu Pro Glu Glu Ile Phe Phe 
            20                  25                  30          


Thr Ile Ser Ile Val Gly Val Leu Glu Asn Leu Ile Val Leu Leu Ala 
        35                  40                  45              


Val Phe Lys Asn Lys Asn Leu Gln Ala Pro Met Tyr Phe Phe Ile Cys 
    50                  55                  60                  


Ser Leu Ala Ile Ser Asp Met Leu Gly Ser Leu Tyr Lys Ile Leu Glu 
65                  70                  75                  80  


Asn Ile Leu Ile Ile Leu Arg Asn Met Gly Tyr Leu Lys Pro Arg Gly 
                85                  90                  95      


Ser Phe Glu Thr Thr Ala Asp Asp Ile Ile Asp Ser Leu Phe Val Leu 
            100                 105                 110         


Ser Leu Leu Gly Ser Ile Phe Ser Leu Ser Val Ile Ala Ala Asp Arg 
        115                 120                 125             


Tyr Ile Thr Ile Phe His Ala Leu Arg Tyr His Ser Ile Val Thr Met 
    130                 135                 140                 


Arg Arg Thr Val Val Val Leu Thr Val Ile Trp Thr Phe Cys Thr Gly 
145                 150                 155                 160 


Thr Gly Ile Thr Met Val Ile Phe Ser His His Val Pro Thr Val Ile 
                165                 170                 175     


Thr Phe Thr Ser Leu Phe Pro Leu Met Leu Val Phe Ile Leu Cys Leu 
            180                 185                 190         


Tyr Val His Met Phe Leu Leu Ala Arg Ser His Thr Arg Lys Ile Ser 
        195                 200                 205             


Thr Leu Pro Arg Ala Asn Met Lys Gly Ala Ile Thr Leu Thr Ile Leu 
    210                 215                 220                 


Leu Gly Val Phe Ile Phe Cys Trp Ala Pro Phe Val Leu His Val Leu 
225                 230                 235                 240 


Leu Met Thr Phe Cys Pro Ser Asn Pro Tyr Cys Ala Cys Tyr Met Ser 
                245                 250                 255     


Leu Phe Gln Val Asn Gly Met Leu Ile Met Cys Asn Ala Val Ile Asp 
            260                 265                 270         


Pro Phe Ile Tyr Ala Phe Arg Ser Pro Glu Leu Arg Asp Ala Phe Lys 
        275                 280                 285             


Lys Met Ile Phe Cys Ser Arg Tyr Trp 
    290                 295         


<210>  37
<211>  378
<212>  PRT
<213>  homo sapiens

<400>  37

Met Val Trp Gly Lys Ile Cys Trp Phe Ser Gln Arg Ala Gly Trp Thr 
1               5                   10                  15      


Val Phe Ala Glu Ser Gln Ile Ser Leu Ser Cys Ser Leu Cys Leu His 
            20                  25                  30          


Ser Gly Asp Gln Glu Ala Gln Asn Pro Asn Leu Val Ser Gln Leu Cys 
        35                  40                  45              


Gly Val Phe Leu Gln Asn Glu Thr Asn Glu Thr Ile His Met Gln Met 
    50                  55                  60                  


Ser Met Ala Val Gly Gln Gln Ala Leu Pro Leu Asn Ile Ile Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Val Ser Leu Cys Gly Val Leu Leu Asn Gly Thr Val 
                85                  90                  95      


Phe Trp Leu Leu Cys Cys Gly Ala Thr Asn Pro Tyr Met Val Tyr Ile 
            100                 105                 110         


Leu His Leu Val Ala Ala Asp Val Ile Tyr Leu Cys Cys Ser Ala Val 
        115                 120                 125             


Gly Phe Leu Gln Val Thr Leu Leu Thr Tyr His Gly Val Val Phe Phe 
    130                 135                 140                 


Ile Pro Asp Phe Leu Ala Ile Leu Ser Pro Phe Ser Phe Glu Val Cys 
145                 150                 155                 160 


Leu Cys Leu Leu Val Ala Ile Ser Thr Glu Arg Cys Val Cys Val Leu 
                165                 170                 175     


Phe Pro Ile Trp Tyr Arg Cys His Arg Pro Lys Tyr Thr Ser Asn Val 
            180                 185                 190         


Val Cys Thr Leu Ile Trp Gly Leu Pro Phe Cys Ile Asn Ile Val Lys 
        195                 200                 205             


Ser Leu Phe Leu Thr Tyr Trp Lys His Val Lys Ala Cys Val Ile Phe 
    210                 215                 220                 


Leu Lys Leu Ser Gly Leu Phe His Ala Ile Leu Ser Leu Val Met Cys 
225                 230                 235                 240 


Val Ser Ser Leu Thr Leu Leu Ile Arg Phe Leu Cys Cys Ser Gln Gln 
                245                 250                 255     


Gln Lys Ala Thr Arg Val Tyr Ala Val Val Gln Ile Ser Ala Pro Met 
            260                 265                 270         


Phe Leu Leu Trp Ala Leu Pro Leu Ser Val Ala Pro Leu Ile Thr Asp 
        275                 280                 285             


Phe Lys Met Phe Val Thr Thr Ser Tyr Leu Ile Ser Leu Phe Leu Ile 
    290                 295                 300                 


Ile Asn Ser Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Leu 
305                 310                 315                 320 


Arg Lys Lys Arg Leu Lys Glu Ser Leu Arg Val Ile Leu Gln Arg Ala 
                325                 330                 335     


Leu Ala Asp Lys Pro Glu Val Gly Arg Asn Lys Lys Ala Ala Gly Ile 
            340                 345                 350         


Asp Pro Met Glu Gln Pro His Ser Thr Gln His Val Glu Asn Leu Leu 
        355                 360                 365             


Pro Arg Glu His Arg Val Asp Val Glu Thr 
    370                 375             


<210>  38
<211>  2527
<212>  PRT
<213>  homo sapiens

<400>  38

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu His Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  39
<211>  1375
<212>  PRT
<213>  homo sapiens

<400>  39

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Gly  Lys Ser His Glu Glu  Ser Ser Pro 
    1040                 1045                 1050             


Glu Val  Val Pro Val Glu Leu  Leu Cys Val Pro Ser  Pro Ala Ser 
    1055                 1060                 1065             


Gln Gly  Asp Leu His Thr Lys  Pro Leu Gly Thr Asp  Asp Asp Phe 
    1070                 1075                 1080             


Trp Gly  Pro Thr Gly Pro Val  Ala Thr Glu Val Val  Asp Lys Glu 
    1085                 1090                 1095             


Lys Asn  Leu Tyr Arg Val His  Phe Pro Val Ala Gly  Ser Tyr Arg 
    1100                 1105                 1110             


Trp Pro  Asn Thr Gly Leu Cys  Phe Val Met Arg Glu  Ala Val Thr 
    1115                 1120                 1125             


Val Glu  Ile Glu Phe Cys Val  Trp Asp Gln Phe Leu  Gly Glu Ile 
    1130                 1135                 1140             


Asn Pro  Gln His Ser Trp Met  Val Ala Gly Pro Leu  Leu Asp Ile 
    1145                 1150                 1155             


Lys Ala  Glu Pro Gly Ala Val  Glu Ala Val His Leu  Pro His Phe 
    1160                 1165                 1170             


Val Ala  Leu Gln Gly Gly His  Val Asp Thr Ser Leu  Phe Gln Met 
    1175                 1180                 1185             


Ala His  Phe Lys Glu Glu Gly  Met Leu Leu Glu Lys  Pro Ala Arg 
    1190                 1195                 1200             


Val Glu  Leu His His Ile Val  Leu Glu Asn Pro Ser  Phe Ser Pro 
    1205                 1210                 1215             


Leu Gly  Val Leu Leu Lys Met  Ile His Asn Ala Leu  Arg Phe Ile 
    1220                 1225                 1230             


Pro Val  Thr Ser Val Val Leu  Leu Tyr His Arg Val  His Pro Glu 
    1235                 1240                 1245             


Glu Val  Thr Phe His Leu Tyr  Leu Ile Pro Ser Asp  Cys Ser Ile 
    1250                 1255                 1260             


Arg Lys  Ala Ile Asp Asp Leu  Glu Met Lys Phe Gln  Phe Val Arg 
    1265                 1270                 1275             


Ile His  Lys Pro Pro Pro Leu  Thr Pro Leu Tyr Met  Gly Cys Arg 
    1280                 1285                 1290             


Tyr Thr  Val Ser Gly Ser Gly  Ser Gly Met Leu Glu  Ile Leu Pro 
    1295                 1300                 1305             


Lys Glu  Leu Glu Leu Cys Tyr  Arg Ser Pro Gly Glu  Asp Gln Leu 
    1310                 1315                 1320             


Phe Ser  Glu Phe Tyr Val Gly  His Leu Gly Ser Gly  Ile Arg Leu 
    1325                 1330                 1335             


Gln Val  Lys Asp Lys Lys Asp  Glu Thr Leu Val Trp  Glu Ala Leu 
    1340                 1345                 1350             


Val Lys  Pro Gly Arg Asn Thr  Ser Gln Pro Trp Asn  Leu Arg Cys 
    1355                 1360                 1365             


Asn Arg  Asp Ala Arg Arg Tyr  
    1370                 1375 


<210>  40
<211>  1429
<212>  PRT
<213>  homo sapiens

<400>  40

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  41
<211>  1473
<212>  PRT
<213>  homo sapiens

<400>  41

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1250                 1255                 1260             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1265                 1270                 1275             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1280                 1285                 1290             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1295                 1300                 1305             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1310                 1315                 1320             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1325                 1330                 1335             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1340                 1345                 1350             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1355                 1360                 1365             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1370                 1375                 1380             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1385                 1390                 1395             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1400                 1405                 1410             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1415                 1420                 1425             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1430                 1435                 1440             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1445                 1450                 1455             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1460                 1465                 1470             


<210>  42
<211>  1443
<212>  PRT
<213>  homo sapiens

<400>  42

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser 
945                 950                 955                 960 


Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser 
                965                 970                 975     


Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser 
            980                 985                 990         


His Val Ala Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
        995                 1000                 1005             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1010                 1015                 1020             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1025                 1030                 1035             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1040                 1045                 1050             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1055                 1060                 1065             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1070                 1075                 1080             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1085                 1090                 1095             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1100                 1105                 1110             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1115                 1120                 1125             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1130                 1135                 1140             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1145                 1150                 1155             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1160                 1165                 1170             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1175                 1180                 1185             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1190                 1195                 1200             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1205                 1210                 1215             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1220                 1225                 1230             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1235                 1240                 1245             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1250                 1255                 1260             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1265                 1270                 1275             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1280                 1285                 1290             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1295                 1300                 1305             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1310                 1315                 1320             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1325                 1330                 1335             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1340                 1345                 1350             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1355                 1360                 1365             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1370                 1375                 1380             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1385                 1390                 1395             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1400                 1405                 1410             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1415                 1420                 1425             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1430                 1435                 1440             


<210>  43
<211>  932
<212>  PRT
<213>  homo sapiens

<400>  43

Met Lys Gln Leu Pro Ala Ala Thr Val Arg Leu Leu Ser Ser Ser Gln 
1               5                   10                  15      


Ile Ile Thr Ser Val Val Ser Val Val Lys Glu Leu Ile Glu Asn Ser 
            20                  25                  30          


Leu Asp Ala Gly Ala Thr Ser Val Asp Val Lys Leu Glu Asn Tyr Gly 
        35                  40                  45              


Phe Asp Lys Ile Glu Val Arg Asp Asn Gly Glu Gly Ile Lys Ala Val 
    50                  55                  60                  


Asp Ala Pro Val Met Ala Met Lys Tyr Tyr Thr Ser Lys Ile Asn Ser 
65                  70                  75                  80  


His Glu Asp Leu Glu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu Ala 
                85                  90                  95      


Leu Gly Ser Ile Cys Cys Ile Ala Glu Val Leu Ile Thr Thr Arg Thr 
            100                 105                 110         


Ala Ala Asp Asn Phe Ser Thr Gln Tyr Val Leu Asp Gly Ser Gly His 
        115                 120                 125             


Ile Leu Ser Gln Lys Pro Ser His Leu Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Ala Leu Arg Leu Phe Lys Asn Leu Pro Val Arg Lys Gln Phe Tyr Ser 
145                 150                 155                 160 


Thr Ala Lys Lys Cys Lys Asp Glu Ile Lys Lys Ile Gln Asp Leu Leu 
                165                 170                 175     


Met Ser Phe Gly Ile Leu Lys Pro Asp Leu Arg Ile Val Phe Val His 
            180                 185                 190         


Asn Lys Ala Val Ile Trp Gln Lys Ser Arg Val Ser Asp His Lys Met 
        195                 200                 205             


Ala Leu Met Ser Val Leu Gly Thr Ala Val Met Asn Asn Met Glu Ser 
    210                 215                 220                 


Phe Gln Tyr His Ser Glu Glu Ser Gln Ile Tyr Leu Ser Gly Phe Leu 
225                 230                 235                 240 


Pro Lys Cys Asp Ala Asp His Ser Phe Thr Ser Leu Ser Thr Pro Glu 
                245                 250                 255     


Arg Ser Phe Ile Phe Ile Asn Ser Arg Pro Val His Gln Lys Asp Ile 
            260                 265                 270         


Leu Lys Leu Ile Arg His His Tyr Asn Leu Lys Cys Leu Lys Glu Ser 
        275                 280                 285             


Thr Arg Leu Tyr Pro Val Phe Phe Leu Lys Ile Asp Val Pro Thr Ala 
    290                 295                 300                 


Asp Val Asp Val Asn Leu Thr Pro Asp Lys Ser Gln Val Leu Leu Gln 
305                 310                 315                 320 


Asn Lys Glu Ser Val Leu Ile Ala Leu Glu Asn Leu Met Thr Thr Cys 
                325                 330                 335     


Tyr Gly Pro Leu Pro Ser Thr Asn Ser Tyr Glu Asn Asn Lys Thr Asp 
            340                 345                 350         


Val Ser Ala Ala Asp Ile Val Leu Ser Lys Thr Ala Glu Thr Asp Val 
        355                 360                 365             


Leu Phe Asn Lys Val Glu Ser Ser Gly Lys Asn Tyr Ser Asn Val Asp 
    370                 375                 380                 


Thr Ser Val Ile Pro Phe Gln Asn Asp Met His Asn Asp Glu Ser Gly 
385                 390                 395                 400 


Lys Asn Thr Asp Asp Cys Leu Asn His Gln Ile Ser Ile Gly Asp Phe 
                405                 410                 415     


Gly Tyr Gly His Cys Ser Ser Glu Ile Ser Asn Ile Asp Lys Asn Thr 
            420                 425                 430         


Lys Asn Ala Phe Gln Asp Ile Ser Met Ser Asn Val Ser Trp Glu Asn 
        435                 440                 445             


Ser Gln Thr Glu Tyr Ser Lys Thr Cys Phe Ile Ser Ser Val Lys His 
    450                 455                 460                 


Thr Gln Ser Glu Asn Gly Asn Lys Asp His Ile Asp Glu Ser Gly Glu 
465                 470                 475                 480 


Asn Glu Glu Glu Ala Gly Leu Glu Asn Ser Ser Glu Ile Ser Ala Asp 
                485                 490                 495     


Glu Trp Ser Arg Gly Asn Ile Leu Lys Asn Ser Val Gly Glu Asn Ile 
            500                 505                 510         


Glu Pro Val Lys Ile Leu Val Pro Glu Lys Ser Leu Pro Cys Lys Val 
        515                 520                 525             


Ser Asn Asn Asn Tyr Pro Ile Pro Glu Gln Met Asn Leu Asn Glu Asp 
    530                 535                 540                 


Ser Cys Asn Lys Lys Ser Asn Val Ile Asp Asn Lys Ser Gly Lys Val 
545                 550                 555                 560 


Thr Ala Tyr Asp Leu Leu Ser Asn Arg Val Ile Lys Lys Pro Met Ser 
                565                 570                 575     


Ala Ser Ala Leu Phe Val Gln Asp His Arg Pro Gln Phe Leu Ile Glu 
            580                 585                 590         


Asn Pro Lys Thr Ser Leu Glu Asp Ala Thr Leu Gln Ile Glu Glu Leu 
        595                 600                 605             


Trp Lys Thr Leu Ser Glu Glu Glu Lys Leu Lys Tyr Glu Glu Lys Ala 
    610                 615                 620                 


Thr Lys Asp Leu Glu Arg Tyr Asn Ser Gln Met Lys Arg Ala Ile Glu 
625                 630                 635                 640 


Gln Glu Ser Gln Met Ser Leu Lys Asp Gly Arg Lys Lys Ile Lys Pro 
                645                 650                 655     


Thr Ser Ala Trp Asn Leu Ala Gln Lys His Lys Leu Lys Thr Ser Leu 
            660                 665                 670         


Ser Asn Gln Pro Lys Leu Asp Glu Leu Leu Gln Ser Gln Ile Glu Lys 
        675                 680                 685             


Arg Arg Ser Gln Asn Ile Lys Met Val Gln Ile Pro Phe Ser Met Lys 
    690                 695                 700                 


Asn Leu Lys Ile Asn Phe Lys Lys Gln Asn Lys Val Asp Leu Glu Glu 
705                 710                 715                 720 


Lys Asp Glu Pro Cys Leu Ile His Asn Leu Arg Phe Pro Asp Ala Trp 
                725                 730                 735     


Leu Met Thr Ser Lys Thr Glu Val Met Leu Leu Asn Pro Tyr Arg Val 
            740                 745                 750         


Glu Glu Ala Leu Leu Phe Lys Arg Leu Leu Glu Asn His Lys Leu Pro 
        755                 760                 765             


Ala Glu Pro Leu Glu Lys Pro Ile Met Leu Thr Glu Ser Leu Phe Asn 
    770                 775                 780                 


Gly Ser His Tyr Leu Asp Val Leu Tyr Lys Met Thr Ala Asp Asp Gln 
785                 790                 795                 800 


Arg Tyr Ser Gly Ser Thr Tyr Leu Ser Asp Pro Arg Leu Thr Ala Asn 
                805                 810                 815     


Gly Phe Lys Ile Lys Leu Ile Pro Gly Val Ser Ile Thr Glu Asn Tyr 
            820                 825                 830         


Leu Glu Ile Glu Gly Met Ala Asn Cys Leu Pro Phe Tyr Gly Val Ala 
        835                 840                 845             


Asp Leu Lys Glu Ile Leu Asn Ala Ile Leu Asn Arg Asn Ala Lys Glu 
    850                 855                 860                 


Val Tyr Glu Cys Arg Pro Arg Lys Val Ile Ser Tyr Leu Glu Gly Glu 
865                 870                 875                 880 


Ala Val Arg Leu Ser Arg Gln Leu Pro Met Tyr Leu Ser Lys Glu Asp 
                885                 890                 895     


Ile Gln Asp Ile Ile Tyr Arg Met Lys His Gln Phe Gly Asn Glu Ile 
            900                 905                 910         


Lys Glu Cys Val His Gly Arg Pro Phe Phe His His Leu Thr Tyr Leu 
        915                 920                 925             


Pro Glu Thr Thr 
    930         


<210>  44
<211>  623
<212>  PRT
<213>  homo sapiens

<400>  44

Met Asn Arg Tyr Thr Thr Met Arg Gln Leu Gly Asp Gly Thr Tyr Gly 
1               5                   10                  15      


Ser Val Leu Met Gly Lys Ser Asn Glu Ser Gly Glu Leu Val Ala Ile 
            20                  25                  30          


Lys Arg Met Lys Arg Lys Phe Tyr Ser Trp Asp Glu Cys Met Asn Leu 
        35                  40                  45              


Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Ile Lys 
    50                  55                  60                  


Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
65                  70                  75                  80  


Tyr Met Lys Glu Asn Leu Tyr Gln Leu Met Lys Asp Arg Asn Lys Leu 
                85                  90                  95      


Phe Pro Glu Ser Val Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
            100                 105                 110         


Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Met Lys Pro 
        115                 120                 125             


Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Glu Leu Arg Ser Gln Pro Pro Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Ser Val 
                165                 170                 175     


Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Ser Ile Met Ala Glu 
            180                 185                 190         


Leu Tyr Met Leu Arg Pro Leu Phe Pro Gly Thr Ser Glu Val Asp Glu 
        195                 200                 205             


Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Ser Asp Trp 
    210                 215                 220                 


Pro Glu Gly Tyr Gln Leu Ala Ser Ser Met Asn Phe Arg Phe Pro Gln 
225                 230                 235                 240 


Cys Val Pro Ile Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Asn Glu 
                245                 250                 255     


Ala Ile Gln Leu Met Thr Glu Met Leu Asn Trp Asp Pro Lys Lys Arg 
            260                 265                 270         


Pro Thr Ala Ser Gln Ala Leu Lys His Pro Tyr Phe Gln Val Gly Gln 
        275                 280                 285             


Val Leu Gly Pro Ser Ser Asn His Leu Glu Ser Lys Gln Ser Leu Asn 
    290                 295                 300                 


Lys Gln Leu Gln Pro Leu Glu Ser Lys Pro Ser Leu Val Glu Val Glu 
305                 310                 315                 320 


Pro Lys Pro Leu Pro Asp Ile Ile Asp Gln Val Val Gly Gln Pro Gln 
                325                 330                 335     


Pro Lys Thr Ser Gln Gln Pro Leu Gln Pro Ile Gln Pro Pro Gln Asn 
            340                 345                 350         


Leu Ser Val Gln Gln Pro Pro Lys Gln Gln Ser Gln Glu Lys Pro Pro 
        355                 360                 365             


Gln Thr Leu Phe Pro Ser Ile Val Lys Asn Met Pro Thr Lys Pro Asn 
    370                 375                 380                 


Gly Thr Leu Ser His Lys Ser Gly Arg Arg Arg Trp Gly Gln Thr Ile 
385                 390                 395                 400 


Phe Lys Ser Gly Asp Ser Trp Glu Glu Leu Glu Asp Tyr Asp Phe Gly 
                405                 410                 415     


Ala Ser His Ser Lys Lys Pro Ser Met Gly Val Phe Lys Glu Lys Arg 
            420                 425                 430         


Lys Lys Asp Ser Pro Phe Arg Leu Pro Glu Pro Val Pro Ser Gly Ser 
        435                 440                 445             


Asn His Ser Thr Gly Glu Asn Lys Ser Leu Pro Ala Val Thr Ser Leu 
    450                 455                 460                 


Lys Ser Asp Ser Glu Leu Ser Thr Ala Pro Thr Ser Lys Gln Tyr Tyr 
465                 470                 475                 480 


Leu Lys Gln Ser Arg Tyr Leu Pro Gly Val Asn Pro Lys Lys Val Ser 
                485                 490                 495     


Leu Ile Ala Ser Gly Lys Glu Ile Asn Pro His Thr Trp Ser Asn Gln 
            500                 505                 510         


Leu Phe Pro Lys Ser Leu Gly Pro Val Gly Ala Glu Leu Ala Phe Lys 
        515                 520                 525             


Arg Ser Asn Ala Gly Asn Leu Gly Ser Tyr Ala Thr Tyr Asn Gln Ser 
    530                 535                 540                 


Gly Tyr Ile Pro Ser Phe Leu Lys Lys Glu Val Gln Ser Ala Gly Gln 
545                 550                 555                 560 


Arg Ile His Leu Ala Pro Leu Asn Ala Thr Ala Ser Glu Tyr Thr Trp 
                565                 570                 575     


Asn Thr Lys Thr Gly Arg Gly Gln Phe Ser Gly Arg Thr Tyr Asn Pro 
            580                 585                 590         


Thr Ala Lys Asn Leu Asn Ile Val Asn Arg Ala Gln Pro Ile Pro Ser 
        595                 600                 605             


Val His Gly Arg Thr Asp Trp Val Ala Lys Tyr Gly Gly His Arg 
    610                 615                 620             


<210>  45
<211>  1380
<212>  PRT
<213>  homo sapiens

<400>  45

Met Ala Ser Gly Arg Asp Glu Arg Pro Pro Trp Arg Leu Gly Arg Leu 
1               5                   10                  15      


Leu Leu Leu Met Cys Leu Leu Leu Leu Gly Ser Ser Ala Arg Ala Ala 
            20                  25                  30          


His Ile Lys Lys Ala Glu Ala Thr Thr Thr Thr Thr Ser Ala Gly Ala 
        35                  40                  45              


Glu Ala Ala Glu Gly Gln Phe Asp Arg Tyr Tyr His Glu Glu Glu Leu 
    50                  55                  60                  


Glu Ser Ala Leu Arg Glu Ala Ala Ala Ala Gly Leu Pro Gly Leu Ala 
65                  70                  75                  80  


Arg Leu Phe Ser Ile Gly Arg Ser Val Glu Gly Arg Pro Leu Trp Val 
                85                  90                  95      


Leu Arg Leu Thr Ala Gly Leu Gly Ser Leu Ile Pro Glu Gly Asp Ala 
            100                 105                 110         


Gly Pro Asp Ala Ala Gly Pro Asp Ala Ala Gly Pro Leu Leu Pro Gly 
        115                 120                 125             


Arg Pro Gln Val Lys Leu Val Gly Asn Met His Gly Asp Glu Thr Val 
    130                 135                 140                 


Ser Arg Gln Val Leu Ile Tyr Leu Ala Arg Glu Leu Ala Ala Gly Tyr 
145                 150                 155                 160 


Arg Arg Gly Asp Pro Arg Leu Val Arg Leu Leu Asn Thr Thr Asp Val 
                165                 170                 175     


Tyr Leu Leu Pro Ser Leu Asn Pro Asp Gly Phe Glu Arg Ala Arg Glu 
            180                 185                 190         


Gly Asp Cys Gly Phe Gly Asp Gly Gly Pro Ser Gly Ala Ser Gly Arg 
        195                 200                 205             


Asp Asn Ser Arg Gly Arg Asp Leu Asn Arg Ser Phe Pro Asp Gln Phe 
    210                 215                 220                 


Ser Thr Gly Glu Pro Pro Ala Leu Asp Glu Val Pro Glu Val Arg Ala 
225                 230                 235                 240 


Leu Ile Glu Trp Ile Arg Arg Asn Lys Phe Val Leu Ser Gly Asn Leu 
                245                 250                 255     


His Gly Gly Ser Val Val Ala Ser Tyr Pro Phe Asp Asp Ser Pro Glu 
            260                 265                 270         


His Lys Ala Thr Gly Ile Tyr Ser Lys Thr Ser Asp Asp Glu Val Phe 
        275                 280                 285             


Lys Tyr Leu Ala Lys Ala Tyr Ala Ser Asn His Pro Ile Met Lys Thr 
    290                 295                 300                 


Gly Glu Pro His Cys Pro Gly Asp Glu Asp Glu Thr Phe Lys Asp Gly 
305                 310                 315                 320 


Ile Thr Asn Gly Ala His Trp Tyr Asp Val Glu Gly Gly Met Gln Asp 
                325                 330                 335     


Tyr Asn Tyr Val Trp Ala Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser 
            340                 345                 350         


Cys Cys Lys Tyr Pro Pro Ala Ser Gln Leu Arg Gln Glu Trp Glu Asn 
        355                 360                 365             


Asn Arg Glu Ser Leu Ile Thr Leu Ile Glu Lys Val His Ile Gly Val 
    370                 375                 380                 


Lys Gly Phe Val Lys Asp Ser Ile Thr Gly Ser Gly Leu Glu Asn Ala 
385                 390                 395                 400 


Thr Ile Ser Val Ala Gly Ile Asn His Asn Ile Thr Thr Gly Arg Phe 
                405                 410                 415     


Gly Asp Phe Tyr Arg Leu Leu Val Pro Gly Thr Tyr Asn Leu Thr Val 
            420                 425                 430         


Val Leu Thr Gly Tyr Met Pro Leu Thr Val Thr Asn Val Val Val Lys 
        435                 440                 445             


Glu Gly Pro Ala Thr Glu Val Asp Phe Ser Leu Arg Pro Thr Val Thr 
    450                 455                 460                 


Ser Val Ile Pro Asp Thr Thr Glu Ala Val Ser Thr Ala Ser Thr Val 
465                 470                 475                 480 


Ala Ile Pro Asn Ile Leu Ser Gly Thr Ser Ser Ser Tyr Gln Pro Ile 
                485                 490                 495     


Gln Pro Lys Asp Phe His His His His Phe Pro Asp Met Glu Ile Phe 
            500                 505                 510         


Leu Arg Arg Phe Ala Asn Glu Tyr Pro Asn Ile Thr Arg Leu Tyr Ser 
        515                 520                 525             


Leu Gly Lys Ser Val Glu Ser Arg Glu Leu Tyr Val Met Glu Ile Ser 
    530                 535                 540                 


Asp Asn Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile 
545                 550                 555                 560 


Gly Asn Met His Gly Asn Glu Val Val Gly Arg Glu Leu Leu Leu Asn 
                565                 570                 575     


Leu Ile Glu Tyr Leu Cys Lys Asn Phe Gly Thr Asp Pro Glu Val Thr 
            580                 585                 590         


Asp Leu Val His Asn Thr Arg Ile His Leu Met Pro Ser Met Asn Pro 
        595                 600                 605             


Asp Gly Tyr Glu Lys Ser Gln Glu Gly Asp Ser Ile Ser Val Ile Gly 
    610                 615                 620                 


Arg Asn Asn Ser Asn Asn Phe Asp Leu Asn Arg Asn Phe Pro Asp Gln 
625                 630                 635                 640 


Phe Val Gln Ile Thr Asp Pro Thr Gln Pro Glu Thr Ile Ala Val Met 
                645                 650                 655     


Ser Trp Met Lys Ser Tyr Pro Phe Val Leu Ser Ala Asn Leu His Gly 
            660                 665                 670         


Gly Ser Leu Val Val Asn Tyr Pro Phe Asp Asp Asp Glu Gln Gly Leu 
        675                 680                 685             


Ala Thr Tyr Ser Lys Ser Pro Asp Asp Ala Val Phe Gln Gln Ile Ala 
    690                 695                 700                 


Leu Ser Tyr Ser Lys Glu Asn Ser Gln Met Phe Gln Gly Arg Pro Cys 
705                 710                 715                 720 


Lys Asn Met Tyr Pro Asn Glu Tyr Phe Pro His Gly Ile Thr Asn Gly 
                725                 730                 735     


Ala Ser Trp Tyr Asn Val Pro Gly Gly Met Gln Asp Trp Asn Tyr Leu 
            740                 745                 750         


Gln Thr Asn Cys Phe Glu Val Thr Ile Glu Leu Gly Cys Val Lys Tyr 
        755                 760                 765             


Pro Leu Glu Lys Glu Leu Pro Asn Phe Trp Glu Gln Asn Arg Arg Ser 
    770                 775                 780                 


Leu Ile Gln Phe Met Lys Gln Val His Gln Gly Val Arg Gly Phe Val 
785                 790                 795                 800 


Leu Asp Ala Thr Asp Gly Arg Gly Ile Leu Asn Ala Thr Ile Ser Val 
                805                 810                 815     


Ala Glu Ile Asn His Pro Val Thr Thr Tyr Lys Thr Gly Asp Tyr Trp 
            820                 825                 830         


Arg Leu Leu Val Pro Gly Thr Tyr Lys Ile Thr Ala Ser Ala Arg Gly 
        835                 840                 845             


Tyr Asn Pro Val Thr Lys Asn Val Thr Val Lys Ser Glu Gly Ala Ile 
    850                 855                 860                 


Gln Val Asn Phe Thr Leu Val Arg Ser Ser Thr Asp Ser Asn Asn Glu 
865                 870                 875                 880 


Ser Lys Lys Gly Lys Gly Ala Ser Ser Ser Thr Asn Asp Ala Ser Asp 
                885                 890                 895     


Pro Thr Thr Lys Glu Phe Glu Thr Leu Ile Lys Asp Leu Ser Ala Glu 
            900                 905                 910         


Asn Gly Leu Glu Ser Leu Met Leu Arg Ser Ser Ser Asn Leu Ala Leu 
        915                 920                 925             


Ala Leu Tyr Arg Tyr His Ser Tyr Lys Asp Leu Ser Glu Phe Leu Arg 
    930                 935                 940                 


Gly Leu Val Met Asn Tyr Pro His Ile Thr Asn Leu Thr Asn Leu Gly 
945                 950                 955                 960 


Gln Ser Thr Glu Tyr Arg His Ile Trp Ser Leu Glu Ile Ser Asn Lys 
                965                 970                 975     


Pro Asn Val Ser Glu Pro Glu Glu Pro Lys Ile Arg Phe Val Ala Gly 
            980                 985                 990         


Ile His Gly Asn Ala Pro Val Gly  Thr Glu Leu Leu Leu  Ala Leu Ala 
        995                 1000                 1005             


Glu Phe  Leu Cys Leu Asn Tyr  Lys Lys Asn Pro Ala  Val Thr Gln 
    1010                 1015                 1020             


Leu Val  Asp Arg Thr Arg Ile  Val Ile Val Pro Ser  Leu Asn Pro 
    1025                 1030                 1035             


Asp Gly  Arg Glu Arg Ala Gln  Glu Lys Asp Cys Thr  Ser Lys Ile 
    1040                 1045                 1050             


Gly Gln  Thr Asn Ala Arg Gly  Lys Asp Leu Asp Thr  Asp Phe Thr 
    1055                 1060                 1065             


Asn Asn  Ala Ser Gln Pro Glu  Thr Lys Ala Ile Ile  Glu Asn Leu 
    1070                 1075                 1080             


Ile Gln  Lys Gln Asp Phe Ser  Leu Ser Val Ala Leu  Asp Gly Gly 
    1085                 1090                 1095             


Ser Met  Leu Val Thr Tyr Pro  Tyr Asp Lys Pro Val  Gln Thr Val 
    1100                 1105                 1110             


Glu Asn  Lys Glu Thr Leu Lys  His Leu Ala Ser Leu  Tyr Ala Asn 
    1115                 1120                 1125             


Asn His  Pro Ser Met His Met  Gly Gln Pro Ser Cys  Pro Asn Lys 
    1130                 1135                 1140             


Ser Asp  Glu Asn Ile Pro Gly  Gly Val Met Arg Gly  Ala Glu Trp 
    1145                 1150                 1155             


His Ser  His Leu Gly Ser Met  Lys Asp Tyr Ser Val  Thr Tyr Gly 
    1160                 1165                 1170             


His Cys  Pro Glu Ile Thr Val  Tyr Thr Ser Cys Cys  Tyr Phe Pro 
    1175                 1180                 1185             


Ser Ala  Ala Arg Leu Pro Ser  Leu Trp Ala Asp Asn  Lys Arg Ser 
    1190                 1195                 1200             


Leu Leu  Ser Met Leu Val Glu  Val His Lys Gly Val  His Gly Phe 
    1205                 1210                 1215             


Val Lys  Asp Lys Thr Gly Lys  Pro Ile Ser Lys Ala  Val Ile Val 
    1220                 1225                 1230             


Leu Asn  Glu Gly Ile Lys Val  Gln Thr Lys Glu Gly  Gly Tyr Phe 
    1235                 1240                 1245             


His Val  Leu Leu Ala Pro Gly  Val His Asn Ile Ile  Ala Ile Ala 
    1250                 1255                 1260             


Asp Gly  Tyr Gln Gln Gln His  Ser Gln Val Phe Val  His His Asp 
    1265                 1270                 1275             


Ala Ala  Ser Ser Val Val Ile  Val Phe Asp Thr Asp  Asn Arg Ile 
    1280                 1285                 1290             


Phe Gly  Leu Pro Arg Glu Leu  Val Val Thr Val Ser  Gly Ala Thr 
    1295                 1300                 1305             


Met Ser  Ala Leu Ile Leu Thr  Ala Cys Ile Ile Trp  Cys Ile Cys 
    1310                 1315                 1320             


Ser Ile  Lys Ser Asn Arg His  Lys Asp Gly Phe His  Arg Leu Arg 
    1325                 1330                 1335             


Gln His  His Asp Glu Tyr Glu  Asp Glu Ile Arg Met  Met Ser Thr 
    1340                 1345                 1350             


Gly Ser  Lys Lys Ser Leu Leu  Ser His Glu Phe Gln  Asp Glu Thr 
    1355                 1360                 1365             


Asp Thr  Glu Glu Glu Thr Leu  Tyr Ser Ser Lys His  
    1370                 1375                 1380 


<210>  46
<211>  167
<212>  PRT
<213>  homo sapiens

<400>  46

Met Leu Pro Glu Lys Ala Leu His Gly His Pro Gln Leu Pro Arg Thr 
1               5                   10                  15      


Val Pro Thr Arg Ala Ala Met Arg Ala Ala Gly Thr Leu Leu Ala Phe 
            20                  25                  30          


Cys Cys Leu Val Leu Ser Thr Thr Gly Gly Pro Ser Pro Asp Thr Cys 
        35                  40                  45              


Ser Gln Asp Leu Asn Ser Arg Val Lys Pro Gly Phe Pro Lys Thr Ile 
    50                  55                  60                  


Lys Thr Asn Asp Pro Gly Val Leu Gln Ala Ala Arg Tyr Ser Val Glu 
65                  70                  75                  80  


Lys Phe Asn Asn Cys Thr Asn Asp Met Phe Leu Phe Lys Glu Ser Arg 
                85                  90                  95      


Ile Thr Arg Ala Leu Val Gln Ile Val Lys Gly Leu Lys Tyr Met Leu 
            100                 105                 110         


Glu Val Glu Ile Gly Arg Thr Thr Cys Lys Lys Asn Gln His Leu Arg 
        115                 120                 125             


Leu Asp Asp Cys Asp Phe Gln Thr Asn His Thr Leu Lys Gln Thr Leu 
    130                 135                 140                 


Ser Cys Tyr Ser Glu Val Trp Val Val Pro Trp Leu Gln His Phe Glu 
145                 150                 155                 160 


Val Pro Val Leu Arg Cys His 
                165         


<210>  47
<211>  384
<212>  PRT
<213>  homo sapiens

<400>  47

Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg 
1               5                   10                  15      


Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
            20                  25                  30          


Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
        35                  40                  45              


Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
    50                  55                  60                  


Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                85                  90                  95      


Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
            100                 105                 110         


Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
        115                 120                 125             


Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys 
    130                 135                 140                 


Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln 
145                 150                 155                 160 


Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln 
                165                 170                 175     


Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
            180                 185                 190         


His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
        195                 200                 205             


Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Ala Thr His Leu His 
    210                 215                 220                 


Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
225                 230                 235                 240 


His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly 
                245                 250                 255     


Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr 
            260                 265                 270         


Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
        275                 280                 285             


Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe 
    290                 295                 300                 


Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
305                 310                 315                 320 


Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser 
                325                 330                 335     


Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
            340                 345                 350         


Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser 
        355                 360                 365             


Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
    370                 375                 380                 


<210>  48
<211>  1445
<212>  PRT
<213>  homo sapiens

<400>  48

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15      


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30          


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45              


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60                  


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80  


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95      


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110         


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125             


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140                 


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160 


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175     


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190         


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205             


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220                 


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240 


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255     


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270         


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285             


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300                 


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320 


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335     


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350         


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365             


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380                 


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400 


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415     


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430         


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445             


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460                 


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480 


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495     


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510         


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525             


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540                 


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575     


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590         


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605             


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620                 


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640 


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655     


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670         


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685             


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700                 


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720 


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735     


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750         


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765             


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780                 


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800 


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815     


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830         


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845             


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860                 


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880 


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895     


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910         


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925             


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940                 


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960 


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975     


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990         


Arg Phe Ser Ile Arg Asn Thr Lys  Val Lys Lys Gly Gln  Lys Gly Asn 
        995                 1000                 1005             


Pro Lys  Gly Arg Gln Asn Glu  Arg Val Val Ile Gln  Tyr His Tyr 
    1010                 1015                 1020             


Thr Gln  Trp Pro Asp Met Gly  Val Pro Glu Tyr Ala  Leu Pro Val 
    1025                 1030                 1035             


Leu Thr  Phe Val Arg Arg Ser  Ser Ala Ala Arg Met  Pro Glu Thr 
    1040                 1045                 1050             


Gly Pro  Val Leu Val His Cys  Ser Ala Gly Val Gly  Arg Thr Gly 
    1055                 1060                 1065             


Thr Tyr  Ile Val Ile Asp Ser  Met Leu Gln Gln Ile  Lys Asp Lys 
    1070                 1075                 1080             


Ser Thr  Val Asn Val Leu Gly  Phe Leu Lys His Ile  Arg Thr Gln 
    1085                 1090                 1095             


Arg Asn  Tyr Leu Val Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His 
    1100                 1105                 1110             


Asp Ala  Leu Leu Glu Ala Ile  Leu Gly Lys Glu Thr  Glu Val Ser 
    1115                 1120                 1125             


Ser Asn  Gln Leu His Ser Tyr  Val Asn Ser Ile Leu  Ile Pro Gly 
    1130                 1135                 1140             


Val Gly  Gly Lys Thr Arg Leu  Glu Lys Gln Phe Lys  Leu Val Thr 
    1145                 1150                 1155             


Gln Cys  Asn Ala Lys Tyr Val  Glu Cys Phe Ser Ala  Gln Lys Glu 
    1160                 1165                 1170             


Cys Asn  Lys Glu Lys Asn Arg  Asn Ser Ser Val Val  Pro Ser Glu 
    1175                 1180                 1185             


Arg Ala  Arg Val Gly Leu Ala  Pro Leu Pro Gly Met  Lys Gly Thr 
    1190                 1195                 1200             


Asp Tyr  Ile Asn Ala Ser Tyr  Ile Met Gly Tyr Tyr  Arg Ser Asn 
    1205                 1210                 1215             


Glu Phe  Ile Ile Thr Gln His  Pro Leu Pro His Thr  Thr Lys Asp 
    1220                 1225                 1230             


Phe Trp  Arg Met Ile Trp Asp  His Asn Ala Gln Ile  Ile Val Met 
    1235                 1240                 1245             


Leu Pro  Asp Asn Gln Ser Leu  Ala Glu Asp Glu Phe  Val Tyr Trp 
    1250                 1255                 1260             


Pro Ser  Arg Glu Glu Ser Met  Asn Cys Glu Ala Phe  Thr Val Thr 
    1265                 1270                 1275             


Leu Ile  Ser Lys Asp Arg Leu  Cys Leu Ser Asn Glu  Glu Gln Ile 
    1280                 1285                 1290             


Ile Ile  His Asp Phe Ile Leu  Glu Ala Thr Gln Asp  Asp Tyr Val 
    1295                 1300                 1305             


Leu Glu  Val Arg His Phe Gln  Cys Pro Lys Trp Pro  Asn Pro Asp 
    1310                 1315                 1320             


Ala Pro  Ile Ser Ser Thr Phe  Glu Leu Ile Asn Val  Ile Lys Glu 
    1325                 1330                 1335             


Glu Ala  Leu Thr Arg Asp Gly  Pro Thr Ile Val His  Asp Glu Tyr 
    1340                 1345                 1350             


Gly Ala  Val Ser Ala Gly Met  Leu Cys Ala Leu Thr  Thr Leu Ser 
    1355                 1360                 1365             


Gln Gln  Leu Glu Asn Glu Asn  Ala Val Asp Val Phe  Gln Val Ala 
    1370                 1375                 1380             


Lys Met  Ile Asn Leu Met Arg  Pro Gly Val Phe Thr  Asp Ile Glu 
    1385                 1390                 1395             


Gln Tyr  Gln Phe Ile Tyr Lys  Ala Met Leu Ser Leu  Val Ser Thr 
    1400                 1405                 1410             


Lys Glu  Asn Gly Asn Gly Pro  Met Thr Val Asp Lys  Asn Gly Ala 
    1415                 1420                 1425             


Val Leu  Ile Ala Asp Glu Ser  Asp Pro Ala Glu Ser  Met Glu Ser 
    1430                 1435                 1440             


Leu Val  
    1445 


<210>  49
<211>  468
<212>  PRT
<213>  homo sapiens

<400>  49

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  50
<211>  365
<212>  PRT
<213>  homo sapiens

<400>  50

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 


<210>  51
<211>  638
<212>  PRT
<213>  homo sapiens

<400>  51

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  52
<211>  207
<212>  PRT
<213>  homo sapiens

<400>  52

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  53
<211>  204
<212>  PRT
<213>  homo sapiens

<400>  53

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  54
<211>  200
<212>  PRT
<213>  homo sapiens

<400>  54

Met Ser Pro Glu Pro Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 
1               5                   10                  15      


His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro Leu Gly Pro Ala 
            20                  25                  30          


Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 
        35                  40                  45              


Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr 
    50                  55                  60                  


Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu 
65                  70                  75                  80  


Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln 
                85                  90                  95      


Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 
            100                 105                 110         


Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr 
        115                 120                 125             


Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 
    130                 135                 140                 


Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln 
145                 150                 155                 160 


Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 
                165                 170                 175     


Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 
            180                 185                 190         


Val Leu Arg His Leu Ala Gln Pro 
        195                 200 


<210>  55
<211>  528
<212>  PRT
<213>  homo sapiens

<400>  55

Met Ala Gly Ser Asp Thr Ala Pro Phe Leu Ser Gln Ala Asp Asp Pro 
1               5                   10                  15      


Asp Asp Gly Pro Val Pro Gly Thr Pro Gly Leu Pro Gly Ser Thr Gly 
            20                  25                  30          


Asn Pro Lys Ser Glu Glu Pro Glu Val Pro Asp Gln Glu Gly Leu Gln 
        35                  40                  45              


Arg Ile Thr Gly Leu Ser Pro Gly Arg Ser Ala Leu Ile Val Ala Val 
    50                  55                  60                  


Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asp Arg Phe Thr Val Ala 
65                  70                  75                  80  


Gly Val Leu Pro Asp Ile Glu Gln Phe Phe Asn Ile Gly Asp Ser Ser 
                85                  90                  95      


Ser Gly Leu Ile Gln Thr Val Phe Ile Ser Ser Tyr Met Val Leu Ala 
            100                 105                 110         


Pro Val Phe Gly Tyr Leu Gly Asp Arg Tyr Asn Arg Lys Tyr Leu Met 
        115                 120                 125             


Cys Gly Gly Ile Ala Phe Trp Ser Leu Val Thr Leu Gly Ser Ser Phe 
    130                 135                 140                 


Ile Pro Gly Glu His Phe Trp Leu Leu Leu Leu Thr Arg Gly Leu Val 
145                 150                 155                 160 


Gly Val Gly Glu Ala Ser Tyr Ser Thr Ile Ala Pro Thr Leu Ile Ala 
                165                 170                 175     


Asp Leu Phe Val Ala Asp Gln Arg Ser Arg Met Leu Ser Ile Phe Tyr 
            180                 185                 190         


Phe Ala Ile Pro Val Gly Ser Gly Leu Gly Tyr Ile Ala Gly Ser Lys 
        195                 200                 205             


Val Lys Asp Met Ala Gly Asp Trp His Trp Ala Leu Arg Val Thr Pro 
    210                 215                 220                 


Gly Leu Gly Val Val Ala Val Leu Leu Leu Phe Leu Val Val Arg Glu 
225                 230                 235                 240 


Pro Pro Arg Gly Ala Val Glu Arg His Ser Asp Leu Pro Pro Leu Asn 
                245                 250                 255     


Pro Thr Ser Trp Trp Ala Asp Leu Arg Ala Leu Ala Arg Asn Pro Ser 
            260                 265                 270         


Phe Val Leu Ser Ser Leu Gly Phe Thr Ala Val Ala Phe Val Thr Gly 
        275                 280                 285             


Ser Leu Ala Leu Trp Ala Pro Ala Phe Leu Leu Arg Ser Arg Val Val 
    290                 295                 300                 


Leu Gly Glu Thr Pro Pro Cys Leu Pro Gly Asp Ser Cys Ser Ser Ser 
305                 310                 315                 320 


Asp Ser Leu Ile Phe Gly Leu Ile Thr Cys Leu Thr Gly Val Leu Gly 
                325                 330                 335     


Val Gly Leu Gly Val Glu Ile Ser Arg Arg Leu Arg His Ser Asn Pro 
            340                 345                 350         


Arg Ala Asp Pro Leu Val Cys Ala Thr Gly Leu Leu Gly Ser Ala Pro 
        355                 360                 365             


Phe Leu Phe Leu Ser Leu Ala Cys Ala Arg Gly Ser Ile Val Ala Thr 
    370                 375                 380                 


Tyr Ile Phe Ile Phe Ile Gly Glu Thr Leu Leu Ser Met Asn Trp Ala 
385                 390                 395                 400 


Ile Val Ala Asp Ile Leu Leu Tyr Val Val Ile Pro Thr Arg Arg Ser 
                405                 410                 415     


Thr Ala Glu Ala Phe Gln Ile Val Leu Ser His Leu Leu Gly Asp Ala 
            420                 425                 430         


Gly Ser Pro Tyr Leu Ile Gly Leu Ile Ser Asp Arg Leu Arg Arg Asn 
        435                 440                 445             


Trp Pro Pro Ser Phe Leu Ser Glu Phe Arg Ala Leu Gln Phe Ser Leu 
    450                 455                 460                 


Met Leu Cys Ala Phe Val Gly Ala Leu Gly Gly Ala Ala Phe Leu Gly 
465                 470                 475                 480 


Thr Ala Ile Phe Ile Glu Ala Asp Arg Arg Arg Ala Gln Leu His Val 
                485                 490                 495     


Gln Gly Leu Leu His Glu Ala Gly Ser Thr Asp Asp Arg Ile Val Val 
            500                 505                 510         


Pro Gln Arg Gly Arg Ser Thr Arg Val Pro Val Ala Ser Val Leu Ile 
        515                 520                 525             


<210>  56
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  56
cgcacctcaa gccctatgt                                                    19


<210>  57
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  57
aacatggtcc gagtagaag                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  58
agaggagctg atagcggag                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  59
aatgggagcg gaagaagtt                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  60
catcctgcag tgggacttc                                                    19


<210>  61
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  61
caacatggtc ttctacctg                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  62
gtacaaatgg ctgtcagtt                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  63
ttgagaatgt tcccacagg                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  64
atggagatgg tactggagt                                                    19


<210>  65
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  65
aggatgcagc taacaacaa                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  66
actgtgcgcg tacacataa                                                    19


<210>  67
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  67
atgctccaca atttgtggc                                                    19


<210>  68
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  68
catgggctat ctcaagcca                                                    19


<210>  69
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  69
aacatgggct atctcaagc                                                    19


<210>  70
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  70
cagaacccaa acctggtat                                                    19


<210>  71
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  71
gccatattgt ctcccttct                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  72
acagcagcgc caaccctat                                                    19


<210>  73
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  73
aaggctcgcg cttcttctt                                                    19


<210>  74
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  74
cattgagaca agaacaagc                                                    19


<210>  75
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  75
agatggactc taccaagcc                                                    19


<210>  76
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  76
attgggaagt caacactgg                                                    19


<210>  77
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  77
cagatgtttc cgcagctga                                                    19


<210>  78
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  78
ccagacaatt acccatgta                                                    19


<210>  79
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  79
acctccaaag caacagagt                                                    19


<210>  80
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  80
agttgttccc tgaatcagt                                                    19


<210>  81
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  81
aagtcccagg aaggagatt                                                    19


<210>  82
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  82
acattcacag gtctttgtg                                                    19


<210>  83
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  83
cgaacgacat gttcttgtt                                                    19


<210>  84
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  84
cttgttccca ggaccttaa                                                    19


<210>  85
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  85
tgacattagc tcccacttt                                                    19


<210>  86
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  86
actgggatgg aggaatcgg                                                    19


<210>  87
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  87
ccaggagtag gaggaaaga                                                    19


<210>  88
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  88
cggagcagca agaccatgt                                                    19


<210>  89
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  89
acagtccggc cgaagactt                                                    19


<210>  90
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  90
actattcatg ctaccgggc                                                    19


<210>  91
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  91
caacatggat ggtcaagga                                                    19


<210>  92
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  92
agtgagatgg gaagcacca                                                    19


<210>  93
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  93
atgacataca tgagggtac                                                    19


<210>  94
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  94
tggaagaact gggaatggc                                                    19


<210>  95
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  95
ctttgccacc accatctgg                                                    19


<210>  96
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  96
aagctcctgt cctcccatc                                                    19


<210>  97
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  97
ccgccatctt cattgaggc                                                    19


<210>  98
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  98
atcttctact ttgccattc                                                    19


<210>  99
<211>  19
<212>  DNA
<213>  homo sapiens

<400>  99
actacatgga ccgcttcac                                                    19


<210>  100
<211>  12
<212>  RNA
<213>  Artificial

<220>
<223>  Loop sequence

<400>  100
guuugcuaua ac                                                           12


<210>  101
<211>  6132
<212>  DNA
<213>  Homo sapiens

<400>  101
aattggaagc aaatgacatc acagcaggtc agagaaaaag ggttgagcgg caggcaccca       60

gagtagtagg tctttggcat taggagcttg agcccagacg gccctagcag ggaccccagc      120

gcccgagaga ccatgcagag gtcgcctctg gaaaaggcca gcgttgtctc caaacttttt      180

ttcagctgga ccagaccaat tttgaggaaa ggatacagac agcgcctgga attgtcagac      240

atataccaaa tcccttctgt tgattctgct gacaatctat ctgaaaaatt ggaaagagaa      300

tgggatagag agctggcttc aaagaaaaat cctaaactca ttaatgccct tcggcgatgt      360

tttttctgga gatttatgtt ctatggaatc tttttatatt taggggaagt caccaaagca      420

gtacagcctc tcttactggg aagaatcata gcttcctatg acccggataa caaggaggaa      480

cgctctatcg cgatttatct aggcataggc ttatgccttc tctttattgt gaggacactg      540

ctcctacacc cagccatttt tggccttcat cacattggaa tgcagatgag aatagctatg      600

tttagtttga tttataagaa gactttaaag ctgtcaagcc gtgttctaga taaaataagt      660

attggacaac ttgttagtct cctttccaac aacctgaaca aatttgatga aggacttgca      720

ttggcacatt tcgtgtggat cgctcctttg caagtggcac tcctcatggg gctaatctgg      780

gagttgttac aggcgtctgc cttctgtgga cttggtttcc tgatagtcct tgcccttttt      840

caggctgggc tagggagaat gatgatgaag tacagagatc agagagctgg gaagatcagt      900

gaaagacttg tgattacctc agaaatgatt gaaaatatcc aatctgttaa ggcatactgc      960

tgggaagaag caatggaaaa aatgattgaa aacttaagac aaacagaact gaaactgact     1020

cggaaggcag cctatgtgag atacttcaat agctcagcct tcttcttctc agggttcttt     1080

gtggtgtttt tatctgtgct tccctatgca ctaatcaaag gaatcatcct ccggaaaata     1140

ttcaccacca tctcattctg cattgttctg cgcatggcgg tcactcggca atttccctgg     1200

gctgtacaaa catggtatga ctctcttgga gcaataaaca aaatacagga tttcttacaa     1260

aagcaagaat ataagacatt ggaatataac ttaacgacta cagaagtagt gatggagaat     1320

gtaacagcct tctgggagga gggatttggg gaattatttg agaaagcaaa acaaaacaat     1380

aacaatagaa aaacttctaa tggtgatgac agcctcttct tcagtaattt ctcacttctt     1440

ggtactcctg tcctgaaaga tattaatttc aagatagaaa gaggacagtt gttggcggtt     1500

gctggatcca ctggagcagg caagacttca cttctaatgg tgattatggg agaactggag     1560

ccttcagagg gtaaaattaa gcacagtgga agaatttcat tctgttctca gttttcctgg     1620

attatgcctg gcaccattaa agaaaatatc atctttggtg tttcctatga tgaatataga     1680

tacagaagcg tcatcaaagc atgccaacta gaagaggaca tctccaagtt tgcagagaaa     1740

gacaatatag ttcttggaga aggtggaatc acactgagtg gaggtcaacg agcaagaatt     1800

tctttagcaa gagcagtata caaagatgct gatttgtatt tattagactc tccttttgga     1860

tacctagatg ttttaacaga aaaagaaata tttgaaagct gtgtctgtaa actgatggct     1920

aacaaaacta ggattttggt cacttctaaa atggaacatt taaagaaagc tgacaaaata     1980

ttaattttgc atgaaggtag cagctatttt tatgggacat tttcagaact ccaaaatcta     2040

cagccagact ttagctcaaa actcatggga tgtgattctt tcgaccaatt tagtgcagaa     2100

agaagaaatt caatcctaac tgagacctta caccgtttct cattagaagg agatgctcct     2160

gtctcctgga cagaaacaaa aaaacaatct tttaaacaga ctggagagtt tggggaaaaa     2220

aggaagaatt ctattctcaa tccaatcaac tctatacgaa aattttccat tgtgcaaaag     2280

actcccttac aaatgaatgg catcgaagag gattctgatg agcctttaga gagaaggctg     2340

tccttagtac cagattctga gcagggagag gcgatactgc ctcgcatcag cgtgatcagc     2400

actggcccca cgcttcaggc acgaaggagg cagtctgtcc tgaacctgat gacacactca     2460

gttaaccaag gtcagaacat tcaccgaaag acaacagcat ccacacgaaa agtgtcactg     2520

gcccctcagg caaacttgac tgaactggat atatattcaa gaaggttatc tcaagaaact     2580

ggcttggaaa taagtgaaga aattaacgaa gaagacttaa aggagtgctt ttttgatgat     2640

atggagagca taccagcagt gactacatgg aacacatacc ttcgatatat tactgtccac     2700

aagagcttaa tttttgtgct aatttggtgc ttagtaattt ttctggcaga ggtggctgct     2760

tctttggttg tgctgtggct ccttggaaac actcctcttc aagacaaagg gaatagtact     2820

catagtagaa ataacagcta tgcagtgatt atcaccagca ccagttcgta ttatgtgttt     2880

tacatttacg tgggagtagc cgacactttg cttgctatgg gattcttcag aggtctacca     2940

ctggtgcata ctctaatcac agtgtcgaaa attttacacc acaaaatgtt acattctgtt     3000

cttcaagcac ctatgtcaac cctcaacacg ttgaaagcag gtgggattct taatagattc     3060

tccaaagata tagcaatttt ggatgacctt ctgcctctta ccatatttga cttcatccag     3120

ttgttattaa ttgtgattgg agctatagca gttgtcgcag ttttacaacc ctacatcttt     3180

gttgcaacag tgccagtgat agtggctttt attatgttga gagcatattt cctccaaacc     3240

tcacagcaac tcaaacaact ggaatctgaa ggcaggagtc caattttcac tcatcttgtt     3300

acaagcttaa aaggactatg gacacttcgt gccttcggac ggcagcctta ctttgaaact     3360

ctgttccaca aagctctgaa tttacatact gccaactggt tcttgtacct gtcaacactg     3420

cgctggttcc aaatgagaat agaaatgatt tttgtcatct tcttcattgc tgttaccttc     3480

atttccattt taacaacagg agaaggagaa ggaagagttg gtattatcct gactttagcc     3540

atgaatatca tgagtacatt gcagtgggct gtaaactcca gcatagatgt ggatagcttg     3600

atgcgatctg tgagccgagt ctttaagttc attgacatgc caacagaagg taaacctacc     3660

aagtcaacca aaccatacaa gaatggccaa ctctcgaaag ttatgattat tgagaattca     3720

cacgtgaaga aagatgacat ctggccctca gggggccaaa tgactgtcaa agatctcaca     3780

gcaaaataca cagaaggtgg aaatgccata ttagagaaca tttccttctc aataagtcct     3840

ggccagaggg tgggcctctt gggaagaact ggatcaggga agagtacttt gttatcagct     3900

tttttgagac tactgaacac tgaaggagaa atccagatcg atggtgtgtc ttgggattca     3960

ataactttgc aacagtggag gaaagccttt ggagtgatac cacagaaagt atttattttt     4020

tctggaacat ttagaaaaaa cttggatccc tatgaacagt ggagtgatca agaaatatgg     4080

aaagttgcag atgaggttgg gctcagatct gtgatagaac agtttcctgg gaagcttgac     4140

tttgtccttg tggatggggg ctgtgtccta agccatggcc acaagcagtt gatgtgcttg     4200

gctagatctg ttctcagtaa ggcgaagatc ttgctgcttg atgaacccag tgctcatttg     4260

gatccagtaa cataccaaat aattagaaga actctaaaac aagcatttgc tgattgcaca     4320

gtaattctct gtgaacacag gatagaagca atgctggaat gccaacaatt tttggtcata     4380

gaagagaaca aagtgcggca gtacgattcc atccagaaac tgctgaacga gaggagcctc     4440

ttccggcaag ccatcagccc ctccgacagg gtgaagctct ttccccaccg gaactcaagc     4500

aagtgcaagt ctaagcccca gattgctgct ctgaaagagg agacagaaga agaggtgcaa     4560

gatacaaggc tttagagagc agcataaatg ttgacatggg acatttgctc atggaattgg     4620

agctcgtggg acagtcacct catggaattg gagctcgtgg aacagttacc tctgcctcag     4680

aaaacaagga tgaattaagt ttttttttaa aaaagaaaca tttggtaagg ggaattgagg     4740

acactgatat gggtcttgat aaatggcttc ctggcaatag tcaaattgtg tgaaaggtac     4800

ttcaaatcct tgaagattta ccacttgtgt tttgcaagcc agattttcct gaaaaccctt     4860

gccatgtgct agtaattgga aaggcagctc taaatgtcaa tcagcctagt tgatcagctt     4920

attgtctagt gaaactcgtt aatttgtagt gttggagaag aactgaaatc atacttctta     4980

gggttatgat taagtaatga taactggaaa cttcagcggt ttatataagc ttgtattcct     5040

ttttctctcc tctccccatg atgtttagaa acacaactat attgtttgct aagcattcca     5100

actatctcat ttccaagcaa gtattagaat accacaggaa ccacaagact gcacatcaaa     5160

atatgcccca ttcaacatct agtgagcagt caggaaagag aacttccaga tcctggaaat     5220

cagggttagt attgtccagg tctaccaaaa atctcaatat ttcagataat cacaatacat     5280

cccttacctg ggaaagggct gttataatct ttcacagggg acaggatggt tcccttgatg     5340

aagaagttga tatgcctttt cccaactcca gaaagtgaca agctcacaga cctttgaact     5400

agagtttagc tggaaaagta tgttagtgca aattgtcaca ggacagccct tctttccaca     5460

gaagctccag gtagagggtg tgtaagtaga taggccatgg gcactgtggg tagacacaca     5520

tgaagtccaa gcatttagat gtataggttg atggtggtat gttttcaggc tagatgtatg     5580

tacttcatgc tgtctacact aagagagaat gagagacaca ctgaagaagc accaatcatg     5640

aattagtttt atatgcttct gttttataat tttgtgaagc aaaatttttt ctctaggaaa     5700

tatttatttt aataatgttt caaacatata taacaatgct gtattttaaa agaatgatta     5760

tgaattacat ttgtataaaa taatttttat atttgaaata ttgacttttt atggcactag     5820

tatttctatg aaatattatg ttaaaactgg gacaggggag aacctagggt gatattaacc     5880

aggggccatg aatcaccttt tggtctggag ggaagccttg gggctgatgc agttgttgcc     5940

cacagctgta tgattcccag ccagcacagc ctcttagatg cagttctgaa gaagatggta     6000

ccaccagtct gactgtttcc atcaagggta cactgccttc tcaactccaa actgactctt     6060

aagaagactg cattatattt attactgtaa gaaaatatca cttgtcaata aaatccatac     6120

atttgtgtga aa                                                         6132


<210>  102
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  102
ccgtttacgt ggagactcgc c                                                 21


<210>  103
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  103
cccccacctt atatatattc tttcc                                             25


