                         SEQUENCE LISTING

<110>  Bradford University
 
<120>  Compositions and Methods

<130>  P107320.WO

<150>  GB0816507.8
<151>  2008-09-10

<150>  GB0908498.9
<151>  2009-05-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210>  2
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Thr Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ala Pro Thr Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Thr Asp Gly Tyr Cys Phe Thr Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Thr Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Thr Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Thr Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Thr Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu 
        115                 120                 125             


Leu Ile Ser Val Thr Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu 
    130                 135                 140                 


Phe Cys Tyr Phe Arg Tyr Lys Arg Gln Glu Thr Arg Pro Arg Tyr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Gln Asp Glu Thr Tyr Ile Pro Pro Gly Glu Ser Leu 
                165                 170                 175     


Arg Asp Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu 
            180                 185                 190         


Pro Leu Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Lys 
        195                 200                 205             


Gln Ile Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg 
    210                 215                 220                 


Gly Glu Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser 
225                 230                 235                 240 


Trp Phe Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu 
                245                 250                 255     


Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp 
            260                 265                 270         


Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr 
        275                 280                 285             


Asp Tyr Leu Lys Ser Thr Thr Leu Asp Ala Lys Ser Met Leu Lys Leu 
    290                 295                 300                 


Ala Tyr Ser Ser Val Ser Gly Leu Cys His Leu His Thr Glu Ile Phe 
305                 310                 315                 320 


Ser Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys 
                325                 330                 335     


Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly 
            340                 345                 350         


Leu Ala Val Lys Phe Ile Ser Asp Thr Asn Glu Val Asp Ile Pro Pro 
        355                 360                 365             


Asn Thr Arg Val Gly Thr Lys Arg Tyr Met Pro Pro Glu Val Leu Asp 
    370                 375                 380                 


Glu Ser Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met 
385                 390                 395                 400 


Tyr Ser Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser 
                405                 410                 415     


Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro 
            420                 425                 430         


Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys 
        435                 440                 445             


Leu Arg Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg 
    450                 455                 460                 


Gln Met Gly Lys Leu Met Thr Glu Cys Trp Ala His Asn Pro Ala Ser 
465                 470                 475                 480 


Arg Leu Thr Ala Leu Arg Val Lys Lys Thr Leu Ala Lys Met Ser Glu 
                485                 490                 495     


Ser Gln Asp Ile Lys Leu 
            500         


<210>  3
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr 
1               5                   10                  15      


Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp 
            20                  25                  30          


Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro 
        35                  40                  45              


Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg 
    50                  55                  60                  


Pro Pro His His Pro Phe Glu Thr Lys Asp Val Ser Glu Tyr Ser Cys 
65                  70                  75                  80  


Arg Glu Leu His Phe Thr Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser 
                85                  90                  95      


Ala Lys Pro Val Thr Glu Leu Val Cys Ser Gly Gln Cys Gly Pro Ala 
            100                 105                 110         


Arg Leu Leu Pro Asn Ala Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser 
        115                 120                 125             


Gly Pro Asp Phe Arg Cys Ile Pro Asp Arg Tyr Arg Ala Gln Arg Val 
    130                 135                 140                 


Gln Leu Leu Cys Pro Gly Gly Glu Ala Pro Arg Ala Arg Lys Val Arg 
145                 150                 155                 160 


Leu Val Ala Ser Cys Lys Cys Lys Arg Leu Thr Arg Phe His Asn Gln 
                165                 170                 175     


Ser Glu Leu Lys Asp Phe Gly Thr Glu Ala Ala Arg Pro Gln Lys Gly 
            180                 185                 190         


Arg Lys Pro Arg Pro Arg Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu 
        195                 200                 205             


Leu Glu Asn Ala Tyr 
    210             


<210>  4
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
1               5                   10                  15      


Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
            20                  25                  30          


Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
        35                  40                  45              


Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
    50                  55                  60                  


Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
65                  70                  75                  80  


His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                85                  90                  95      


Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
            100                 105                 110         


Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
        115                 120                 125             


Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
    130                 135                 140                 


Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
145                 150                 155                 160 


Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                165                 170                 175     


Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
            180                 185                 190         


Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
        195                 200                 205             


Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
    210                 215                 220                 


Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
225                 230                 235                 240 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                245                 250                 255     


Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
            260                 265                 270         


Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
        275                 280                 285             


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
    290                 295                 300                 


Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
305                 310                 315                 320 


Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                325                 330                 335     


Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
            340                 345                 350         


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
        355                 360                 365             


Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
    370                 375                 380                 


Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
385                 390                 395                 400 


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                405                 410                 415     


Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
            420                 425                 430         


Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
        435                 440                 445             


Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
    450                 455                 460                 


Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
465                 470                 475                 480 


Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                485                 490                 495     


Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
            500                 505                 510         


Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
        515                 520                 525             


Asp Val Lys Ile 
    530         


