                         SEQUENCE LISTING

<110>  Galderma research & Development
 
<120>  Modulateurs de FZD2 dans le traitement de l'alopcie

<130>  OA08309E

<150>  FR0856315
<151>  2008-09-19

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  1983
<212>  DNA
<213>  Homosapiens

<400>  1
cgagtaaagt ttgcaaagag gcgcgggagg cggcagccgc agcgaggagg cggcggggaa     60

gaagcgcagt ctccgggttg ggggcggggg cggggggggc gccaaggagc cgggtggggg    120

gcggcggcca gcatgcggcc ccgcagcgcc ctgccccgcc tgctgctgcc gctgctgctg    180

ctgcccgccg ccgggccggc ccagttccac ggggagaagg gcatctccat cccggaccac    240

ggcttctgcc agcccatctc catcccgctg tgcacggaca tcgcctacaa ccagaccatc    300

atgcccaacc ttctgggcca cacgaaccag gaggacgcag gcctagaggt gcaccagttc    360

tatccgctgg tgaaggtgca gtgctcgccc gaactgcgct tcttcctgtg ctccatgtac    420

gcacccgtgt gcaccgtgct ggaacaggcc atcccgccgt gccgctctat ctgtgagcgc    480

gcgcgccagg gctgcgaagc cctcatgaac aagttcggtt ttcagtggcc cgagcgcctg    540

cgctgcgagc acttcccgcg ccacggcgcc gagcagatct gcgtcggcca gaaccactcc    600

gaggacggag ctcccgcgct actcaccacc gcgccgccgc cgggactgca gccgggtgcc    660

gggggcaccc cgggtggccc gggcggcggc ggcgctcccc cgcgctacgc cacgctggag    720

caccccttcc actgcccgcg cgtcctcaag gtgccatcct atctcagcta caagtttctg    780

ggcgagcgtg attgtgctgc gccctgcgaa cctgcgcggc ccgatggttc catgttcttc    840

tcacaggagg agacgcgttt cgcgcgcctc tggatcctca cctggtcggt gctgtgctgc    900

gcttccacct tcttcactgt caccacgtac ttggtagaca tgcagcgctt ccgctaccca    960

gagcggccta tcatttttct gtcgggctgc tacaccatgg tgtcggtggc ctacatcgcg   1020

ggcttcgtgc tccaggagcg cgtggtgtgc aacgagcgct tctccgagga cggttaccgc   1080

acggtggtgc agggcaccaa gaaggagggc tgcaccatcc tcttcatgat gctctacttc   1140

ttcagcatgg ccagctccat ctggtgggtc atcctgtcgc tcacctggtt cctggcagcc   1200

ggcatgaagt ggggccacga ggccatcgag gccaactctc agtacttcca cctggccgcc   1260

tgggccgtgc cggccgtcaa gaccatcacc atcctggcca tgggccagat cgacggcgac   1320

ctgctgagcg gcgtgtgctt cgtaggcctc aacagcctgg acccgctgcg gggcttcgtg   1380

ctagcgccgc tcttcgtgta cctgttcatc ggcacgtcct tcctcctggc cggcttcgtg   1440

tcgctcttcc gcatccgcac catcatgaag cacgacggca ccaagaccga aaagctggag   1500

cggctcatgg tgcgcatcgg cgtcttctcc gtgctctaca cagtgcccgc caccatcgtc   1560

atcgcttgct acttctacga gcaggccttc cgcgagcact gggagcgctc gtgggtgagc   1620

cagcactgca agagcctggc catcccgtgc ccggcgcact acacgccgcg catgtcgccc   1680

gacttcacgg tctacatgat caaatacctc atgacgctca tcgtgggcat cacgtcgggc   1740

ttctggatct ggtcgggcaa gacgctgcac tcgtggagga agttctacac tcgcctcacc   1800

aacagccgac acggtgagac caccgtgtga gggacgcccc caggccggaa ccgcgcggcg   1860

ctttcctccg cccggggtgg ggcccctaca gactccgtat tttatttttt taaataaaaa   1920

acgatcgaaa ccatttcact tttaggttgc tttttaaaag agaactctct gcccaacacc   1980

ccc                                                                 1983


<210>  2
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Arg Ser Ala Leu Pro Arg Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Ala Gly Pro Ala Gln Phe His Gly Glu Lys Gly Ile Ser 
            20                  25                  30          


Ile Pro Asp His Gly Phe Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr 
        35                  40                  45              


Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val 
65                  70                  75                  80  


Lys Val Gln Cys Ser Pro Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr 
                85                  90                  95      


Ala Pro Val Cys Thr Val Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser 
            100                 105                 110         


Ile Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe 
        115                 120                 125             


Gly Phe Gln Trp Pro Glu Arg Leu Arg Cys Glu His Phe Pro Arg His 
    130                 135                 140                 


Gly Ala Glu Gln Ile Cys Val Gly Gln Asn His Ser Glu Asp Gly Ala 
145                 150                 155                 160 


Pro Ala Leu Leu Thr Thr Ala Pro Pro Pro Gly Leu Gln Pro Gly Ala 
                165                 170                 175     


Gly Gly Thr Pro Gly Gly Pro Gly Gly Gly Gly Ala Pro Pro Arg Tyr 
            180                 185                 190         


Ala Thr Leu Glu His Pro Phe His Cys Pro Arg Val Leu Lys Val Pro 
        195                 200                 205             


Ser Tyr Leu Ser Tyr Lys Phe Leu Gly Glu Arg Asp Cys Ala Ala Pro 
    210                 215                 220                 


Cys Glu Pro Ala Arg Pro Asp Gly Ser Met Phe Phe Ser Gln Glu Glu 
225                 230                 235                 240 


Thr Arg Phe Ala Arg Leu Trp Ile Leu Thr Trp Ser Val Leu Cys Cys 
                245                 250                 255     


Ala Ser Thr Phe Phe Thr Val Thr Thr Tyr Leu Val Asp Met Gln Arg 
            260                 265                 270         


Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr 
        275                 280                 285             


Met Val Ser Val Ala Tyr Ile Ala Gly Phe Val Leu Gln Glu Arg Val 
    290                 295                 300                 


Val Cys Asn Glu Arg Phe Ser Glu Asp Gly Tyr Arg Thr Val Val Gln 
305                 310                 315                 320 


Gly Thr Lys Lys Glu Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe 
                325                 330                 335     


Phe Ser Met Ala Ser Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp 
            340                 345                 350         


Phe Leu Ala Ala Gly Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn 
        355                 360                 365             


Ser Gln Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala Val Lys Thr 
    370                 375                 380                 


Ile Thr Ile Leu Ala Met Gly Gln Ile Asp Gly Asp Leu Leu Ser Gly 
385                 390                 395                 400 


Val Cys Phe Val Gly Leu Asn Ser Leu Asp Pro Leu Arg Gly Phe Val 
                405                 410                 415     


Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu 
            420                 425                 430         


Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp 
        435                 440                 445             


Gly Thr Lys Thr Glu Lys Leu Glu Arg Leu Met Val Arg Ile Gly Val 
    450                 455                 460                 


Phe Ser Val Leu Tyr Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr 
465                 470                 475                 480 


Phe Tyr Glu Gln Ala Phe Arg Glu His Trp Glu Arg Ser Trp Val Ser 
                485                 490                 495     


Gln His Cys Lys Ser Leu Ala Ile Pro Cys Pro Ala His Tyr Thr Pro 
            500                 505                 510         


Arg Met Ser Pro Asp Phe Thr Val Tyr Met Ile Lys Tyr Leu Met Thr 
        515                 520                 525             


Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys Thr 
    530                 535                 540                 


Leu His Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Arg His 
545                 550                 555                 560 


Gly Glu Thr Thr Val 
                565 


