                               SEQUENCE LISTING	

<110> UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
 
<120> ORALLY ADMINISTERABLE VACCINE FOR YERSINIA PESTIS

<130> 10669-045PCT

<140> PCT/US2009/045215
<141> 2009-05-27

<150> 61/056,365
<151> 2008-05-27

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 513
<212> DNA
<213> Yersinia pestis

<400> 1
ttattggtta gatacggtta cggttacagc atcagtgtat ttacctgctg caagtttacc       60

gcctttggaa ccaattgagc gaacaaagaa atcctggctg cccgtagcca agacgacgtc      120

atcccccaca aggttctcac cgtttacctt aggagagata tcaaaatctc tagaatcctt      180

gccaatcact tttgtagtga attggtggtt atttccatcc tgagaagtaa atgttaagta      240

catgggatca cccgcggcat ctgtaaagtt aacagatgtg ctagtggttc ctgttttata      300

gccgccaaga gtaagcgtac caacaagtaa ttctgtatcg atgtttccat tgtccataat      360

tgtaattgga gagccttcct tatatgtaag agtgatgcgg gctggttcaa caagagttgc      420

cgttgcagtg gtgcttgcag ttaaatctgc cgcattagca gttgcaatag ttccaaataa      480

tgcaatggcg ataacggaac tgattttttt cat                                   513


<210> 2
<211> 170
<212> PRT
<213> Yersinia pestis

<400> 2
Met Lys Lys Ile Ser Ser Val Ile Ala Ile Ala Leu Phe Gly Thr Ile 
1               5                   10                  15      


Ala Thr Ala Asn Ala Ala Asp Leu Thr Ala Ser Thr Thr Ala Thr Ala 
            20                  25                  30          


Thr Leu Val Glu Pro Ala Arg Ile Thr Leu Thr Tyr Lys Glu Gly Ser 
        35                  40                  45              


Pro Ile Thr Ile Met Asp Asn Gly Asn Ile Asp Thr Glu Leu Leu Val 
    50                  55                  60                  


Gly Thr Leu Thr Leu Gly Gly Tyr Lys Thr Gly Thr Thr Ser Thr Ser 
65                  70                  75                  80  


Val Asn Phe Thr Asp Ala Ala Gly Asp Pro Met Tyr Leu Thr Phe Thr 
                85                  90                  95      


Ser Gln Asp Gly Asn Asn His Gln Phe Thr Thr Lys Val Ile Gly Lys 
            100                 105                 110         


Asp Ser Arg Asp Phe Asp Ile Ser Pro Lys Val Asn Gly Glu Asn Leu 
        115                 120                 125             


Val Gly Asp Asp Val Val Leu Ala Thr Gly Ser Gln Asp Phe Phe Val 
    130                 135                 140                 


Arg Ser Ile Gly Ser Lys Gly Gly Lys Leu Ala Ala Gly Lys Tyr Thr 
145                 150                 155                 160 


Asp Ala Val Thr Val Thr Val Ser Asn Gln 
                165                 170 


<210> 3
<211> 2502
<212> DNA
<213> Yersinia pestis

<400> 3
tcagttattt aagatgcagg ttgtggataa cctataagca ccagaaatat ccgttttttc       60

tggtagaact acattagatg aacatgattg atttttatct ctcccccact taacaagtat      120

ttttgatttt ttaggtagtc cagtcaaata gacaccgcta ttatctccga caatgccaga      180

gctggatgat tgcccttcaa tggtaactat agaaccaaat ggaacaggtt tattgtcaga      240

gcgttttaaa tgtaaaaaca atcgtccacc aatccttgcg ttaaattttg ctaatactac      300

agctcccttt gtcgggatca cgctaacaat attatttgtt atctctgcat cattgggtaa      360

agtaactggg ttaatttcta ccttattctc tctgtaaggg gttaagtaac cataattggt      420

gtacccccta aagtctgttt tcatgcctgg ccagtatccc actgaagcac cgcttatatc      480

aggggcttgt actaatgcaa tagtatctcc agttttttgg ccagccgtta taccgtactg      540

agttattacc atattgccat ttacacctat accaagttgg ctttgggttt gatcgtagct      600

gtagttacca ctgatctccc cataagttcc tcgataattc aaattcagtg cattggaggt      660

atattttctg cccttttcat taaaacgttc gcgaacgtcc cagtataatt ggcgatcaaa      720

ggcttcaccg tacacaccta cctcatgggt agtgttacca tgagaatctg atgtcatttg      780

gtaatttgaa tttattgagt tattacctag ccagcgactg agaggaaaac tcaaccagat      840

attagataat agctcactag ttttttctcc atacttattg atattctgtg tcttcgataa      900

atttaaagtc aatgacatac cattcctaaa aaaatggtta tagcctacag aaaaagaagt      960

tgtgctccta ctgtcacgcc aatagttttt tctgtagcca ctgaaattaa gcgtccccga     1020

accaggtatg ctttgactta aattgaattg cactttgttt ttgggtttag cataatcaaa     1080

acggcaatcg tttctagtat taggtttaca ataagtattt aacgtgtcag cgagtttgtt     1140

aaatccttct gtggcgtatt cctcgctagc aatgtttaac gatgttccac tctgcaagta     1200

cttattatat cgaacgcgcc aacgttggcc gctttctttt ttttgtttat ttttctggct     1260

gtctgcttga gtaacatctg tagatatggc accaaaatca cccaacatag caccgatacc     1320

cagagctgcg gcatgataat tttgggaccc ttgtagtcca ccatataacg taagattcct     1380

tggcaaacca tatttcatcc caagagcgcc aacatacgat gtttgtgtaa gatcattagc     1440

tggacgatat tctcccccca tcattgaata ttcgaaatag cccttccgta atgccactgc     1500

tggtgtgtca tatggaactg taaaaacttg ctttgttcca tcactttcat gaatgatgac     1560

tttcagctca ccactccccc cacccagagg aagatttgct aactcaaatg gtcccgaggg     1620

caccaactca ttacttacag tgtagccatc tcttaaaacc tctaccctgg cttgtgtacg     1680

tgcgataccg cgaacaactg gagcaaaatt ccattggtaa taaggaacca tcgattcatc     1740

tgaagcaatt tttatcccct taatcgggat actgtcaaag atactgctat cagaataggt     1800

ttcccccaat gtcaaacggc tcttaattgt attcaatcct cgctcggcat aaatatacga     1860

acgctgccat ccttgttgtt tccaccatga ggttgaacta cgaaagcgcc aagcccctat     1920

gtttaatccc ggttgcaact gagcataata agagtccaga gacttgcctc cttctctgaa     1980

ttttcttgtc tgcatgttcg tattataatt catgaacaga gcaggaatgc cgtcatccca     2040

caattgcatt ggcataatgc catcaaatct aggtaaaagt gcctgtggtg gcacaattaa     2100

cgataatttc tgctgattaa aataaaactg cacatctgaa tgtggtattg ctaataaatc     2160

aacacattgc tctgtaccag attttattaa atcaggatat ttatctatat caatgccata     2220

ctttgtcaat tgtaaggatg ataggcatgg ccaaagaagt tcttttccat tatgtttttc     2280

tagacggaag tcgatatttc cagagtctac ctttcgacca tttacaaaaa cattaacaaa     2340

ataattacct ggaagttgaa gtccttgatt aaaaagagat acatctatac tctctccact     2400

attcgtatca agcatagtag agtcaaaagt atatgcgcgt ccccaacaag gcaatgttgc     2460

caaagttaac cctgcacaca ggaacagctt tgaatacctc at                        2502


<210> 4
<211> 775
<212> PRT
<213> Yersinia pestis

<400> 4
Met Arg Tyr Ser Lys Leu Phe Leu Cys Ala Gly Leu Thr Leu Ala Thr 
1               5                   10                  15      


Leu Pro Cys Trp Gly Arg Ala Tyr Thr Phe Asp Ser Thr Met Leu Asp 
            20                  25                  30          


Thr Asn Ser Gly Glu Ser Ile Asp Val Ser Leu Phe Pro Asp Leu Ile 
        35                  40                  45              


Lys Ser Gly Thr Glu Gln Cys Val Asp Leu Leu Ala Ile Pro His Ser 
    50                  55                  60                  


Asp Val Gln Phe Tyr Phe Asn Gln Gln Lys Leu Ser Leu Ile Val Pro 
65                  70                  75                  80  


Pro Gln Ala Leu Leu Pro Arg Phe Asp Gly Ile Met Pro Met Gln Leu 
                85                  90                  95      


Trp Asp Asp Gly Ile Pro Ala Leu Phe Met Asn Tyr Asn Thr Asn Met 
            100                 105                 110         


Gln Thr Arg Lys Phe Arg Glu Gly Gly Lys Ser Leu Asp Ser Tyr Tyr 
        115                 120                 125             


Ala Gln Leu Gln Pro Gly Leu Asn Ile Gly Ala Trp Arg Phe Arg Ser 
    130                 135                 140                 


Ser Thr Ser Trp Trp Lys Gln Gln Gly Trp Gln Arg Ser Tyr Ile Tyr 
145                 150                 155                 160 


Ala Glu Arg Gly Leu Asn Thr Ile Lys Ser Arg Leu Thr Leu Gly Glu 
                165                 170                 175     


Thr Tyr Ser Asp Ser Ser Ile Phe Asp Ser Ile Pro Ile Lys Gly Ile 
            180                 185                 190         


Lys Ile Ala Ser Asp Glu Ser Met Val Pro Tyr Tyr Gln Trp Asn Phe 
        195                 200                 205             


Ala Pro Val Val Arg Gly Ile Ala Arg Thr Gln Ala Arg Val Glu Val 
    210                 215                 220                 


Leu Arg Asp Gly Tyr Thr Val Ser Asn Glu Leu Val Pro Ser Gly Pro 
225                 230                 235                 240 


Phe Glu Leu Ala Asn Leu Pro Leu Gly Gly Gly Ser Gly Glu Leu Lys 
                245                 250                 255     


Val Ile Ile His Glu Ser Asp Gly Thr Lys Gln Val Phe Thr Val Pro 
            260                 265                 270         


Tyr Asp Thr Pro Ala Val Ala Leu Arg Lys Gly Tyr Phe Glu Tyr Ser 
        275                 280                 285             


Met Met Gly Gly Glu Tyr Arg Pro Ala Asn Asp Leu Thr Gln Thr Ser 
    290                 295                 300                 


Tyr Val Gly Ala Leu Gly Met Lys Tyr Gly Leu Pro Arg Asn Leu Thr 
305                 310                 315                 320 


Leu Tyr Gly Gly Leu Gln Gly Ser Gln Asn Tyr His Ala Ala Ala Leu 
                325                 330                 335     


Gly Ile Gly Ala Met Leu Gly Asp Phe Gly Ala Ile Ser Thr Asp Val 
            340                 345                 350         


Thr Gln Ala Asp Ser Gln Lys Asn Lys Gln Lys Lys Glu Ser Gly Gln 
        355                 360                 365             


Arg Trp Arg Val Arg Tyr Asn Lys Tyr Leu Gln Ser Gly Thr Ser Leu 
    370                 375                 380                 


Asn Ile Ala Ser Glu Glu Tyr Ala Thr Glu Gly Phe Asn Lys Leu Ala 
385                 390                 395                 400 


Asp Thr Leu Asn Thr Tyr Cys Lys Pro Asn Thr Arg Asn Asp Cys Arg 
                405                 410                 415     


Phe Asp Tyr Ala Lys Pro Lys Asn Lys Val Gln Phe Asn Leu Ser Gln 
            420                 425                 430         


Ser Ile Pro Gly Ser Gly Thr Leu Asn Phe Ser Gly Tyr Arg Lys Asn 
        435                 440                 445             


Tyr Trp Arg Asp Ser Arg Ser Thr Thr Ser Phe Ser Val Gly Tyr Asn 
    450                 455                 460                 


His Phe Phe Arg Asn Gly Met Ser Leu Thr Leu Asn Leu Ser Lys Thr 
465                 470                 475                 480 


Gln Asn Ile Asn Lys Tyr Gly Glu Lys Thr Ser Glu Leu Leu Ser Asn 
                485                 490                 495     


Ile Trp Leu Ser Phe Pro Leu Ser Arg Trp Leu Gly Asn Asn Ser Ile 
            500                 505                 510         


Asn Ser Asn Tyr Gln Met Thr Ser Asp Ser His Gly Asn Thr Thr His 
        515                 520                 525             


Glu Val Gly Val Tyr Gly Glu Ala Phe Asp Arg Gln Leu Tyr Trp Asp 
    530                 535                 540                 


Val Arg Glu Arg Phe Asn Glu Lys Gly Arg Lys Tyr Thr Ser Asn Ala 
545                 550                 555                 560 


Leu Asn Leu Asn Tyr Arg Gly Thr Tyr Gly Glu Ile Ser Gly Asn Tyr 
                565                 570                 575     


Ser Tyr Asp Gln Thr Gln Ser Gln Leu Gly Ile Gly Val Asn Gly Asn 
            580                 585                 590         


Met Val Ile Thr Gln Tyr Gly Ile Thr Ala Gly Gln Lys Thr Gly Asp 
        595                 600                 605             


Thr Ile Ala Leu Val Gln Ala Pro Asp Ile Ser Gly Ala Ser Val Gly 
    610                 615                 620                 


Tyr Trp Pro Gly Met Lys Thr Asp Phe Arg Gly Tyr Thr Asn Tyr Gly 
625                 630                 635                 640 


Tyr Leu Thr Pro Tyr Arg Glu Asn Lys Val Glu Ile Asn Pro Val Thr 
                645                 650                 655     


Leu Pro Asn Asp Ala Glu Ile Thr Asn Asn Ile Val Ser Val Ile Pro 
            660                 665                 670         


Thr Lys Gly Ala Val Val Leu Ala Lys Phe Asn Ala Arg Ile Gly Gly 
        675                 680                 685             


Arg Leu Phe Leu His Leu Lys Arg Ser Asp Asn Lys Pro Val Pro Phe 
    690                 695                 700                 


Gly Ser Ile Val Thr Ile Glu Gly Gln Ser Ser Ser Ser Gly Ile Val 
705                 710                 715                 720 


Gly Asp Asn Ser Gly Val Tyr Leu Thr Gly Leu Pro Lys Lys Ser Lys 
                725                 730                 735     


Ile Leu Val Lys Trp Gly Arg Asp Lys Asn Gln Ser Cys Ser Ser Asn 
            740                 745                 750         


Val Val Leu Pro Glu Lys Thr Asp Ile Ser Gly Ala Tyr Arg Leu Ser 
        755                 760                 765             


Thr Thr Cys Ile Leu Asn Asn 
    770                 775 


<210> 5
<211> 810
<212> DNA
<213> Yersinia pestis

<400> 5
tcataaagtc acatttttgg aatacaaacg atccaaccct ccctgatcat taattattct       60

ccacgaaaca ttacgtgctc ccgctagtcc ttttggcaaa tcaaaagccc acgtcgattt      120

aggtggaata tagtgagaag gaatactttt ccctccaaat gttaattcac ctatgttcat      180

gtagaaaggt gaggggtttt cagcaattag cttcccccca tcaactttcc agcttaagtt      240

ttcagcaaac tgtatagggg ttccttttaa ttcattcggt cgaaccaaaa gcttaatgca      300

attattaatt gcgaattgca cgaacactcc cacatctttg tctggattga atttttgctt      360

atttgtcgca tcatcaaccc atatatcttc atcctttggt ggaatccctt ttacgcataa      420

ccactttagg ctctctttat ctcgcgggaa aacacctcca gcctgagcta tacgcaaaga      480

attttgttgc ttagcatcca atcgaaacaa tggcggagtg accacgaaag gatcctctga      540

ttctttttct ttattctcgt cgtagatcct agactgaatg agaaccggat aatcttgggt      600

gtttttcacc gagaccataa cgccagcagc atctaacggg tatatgatcc tactctcacc      660

tatagtcacg ccatactctt tgcttgcgaa tttgatatct ggttgagcag agttcgcagc      720

aaaactaagc atgccgaaag taataattcc taacgtactt aatctattta aaatcatgag      780

cttaacctcc ttacggaatg gtgacaacac                                       810


<210> 6
<211> 269
<212> PRT
<213> Yersinia pestis

<400> 6
Met Leu Ser Pro Phe Arg Lys Glu Val Lys Leu Met Ile Leu Asn Arg 
1               5                   10                  15      


Leu Ser Thr Leu Gly Ile Ile Thr Phe Gly Met Leu Ser Phe Ala Ala 
            20                  25                  30          


Asn Ser Ala Gln Pro Asp Ile Lys Phe Ala Ser Lys Glu Tyr Gly Val 
        35                  40                  45              


Thr Ile Gly Glu Ser Arg Ile Ile Tyr Pro Leu Asp Ala Ala Gly Val 
    50                  55                  60                  


Met Val Ser Val Lys Asn Thr Gln Asp Tyr Pro Val Leu Ile Gln Ser 
65                  70                  75                  80  


Arg Ile Tyr Asp Glu Asn Lys Glu Lys Glu Ser Glu Asp Pro Phe Val 
                85                  90                  95      


Val Thr Pro Pro Leu Phe Arg Leu Asp Ala Lys Gln Gln Asn Ser Leu 
            100                 105                 110         


Arg Ile Ala Gln Ala Gly Gly Val Phe Pro Arg Asp Lys Glu Ser Leu 
        115                 120                 125             


Lys Trp Leu Cys Val Lys Gly Ile Pro Pro Lys Asp Glu Asp Ile Trp 
    130                 135                 140                 


Val Asp Asp Ala Thr Asn Lys Gln Lys Phe Asn Pro Asp Lys Asp Val 
145                 150                 155                 160 


Gly Val Phe Val Gln Phe Ala Ile Asn Asn Cys Ile Lys Leu Leu Val 
                165                 170                 175     


Arg Pro Asn Glu Leu Lys Gly Thr Pro Ile Gln Phe Ala Glu Asn Leu 
            180                 185                 190         


Ser Trp Lys Val Asp Gly Gly Lys Leu Ile Ala Glu Asn Pro Ser Pro 
        195                 200                 205             


Phe Tyr Met Asn Ile Gly Glu Leu Thr Phe Gly Gly Lys Ser Ile Pro 
    210                 215                 220                 


Ser His Tyr Ile Pro Pro Lys Ser Thr Trp Ala Phe Asp Leu Pro Lys 
225                 230                 235                 240 


Gly Leu Ala Gly Ala Arg Asn Val Ser Trp Arg Ile Ile Asn Asp Gln 
                245                 250                 255     


Gly Gly Leu Asp Arg Leu Tyr Ser Lys Asn Val Thr Leu 
            260                 265                 


<210> 7
<211> 924
<212> DNA
<213> Yersinia pestis

<400> 7
ttgatttggg ttatattcat gctaaaacag atgactgtaa attcaattat tcaatatata       60

gaagagaatc tcgagtcgaa attcattaac attgactgtt tggttttgta ttcaggattc      120

agcagaaggt atttgcaaat ttcctttaag gaatatgtcg gaatgcctat tggaacatat      180

attagagtta gaagggctag tagagctgct gcactattac ggcttaccag gctgacaata      240

atagagatat cagcaaagct tttttatgat tcgcaacaga cattcaccag agaatttaag      300

aaaatatttg gttatacccc acggcagtat aggatgatcc ctttttggtc ctttaaaggt      360

ttgttgggta gaagggaaat taactgtgaa taccttcaac cacgaatctg ttaccttaaa      420

gagagaaata taattggtca atgctttaat tttagggatt tagtgttcta ctctgggata      480

gattcaaaat gtagattggg taagttatat gattcgttga agaaaaatac agctataaca      540

gtatcaaaca gaatcccctt tcatgataaa acgaatgaca ttattgcaag aacggttgtt      600

tgggatagga ataagcattt cagcgatagt gaaataaagg tagataaagg cctgtatgct      660

tattttttct tcaatgatac atatgatcag tatgttcatc acatgtacaa catatattat      720

aactctttgc ctatttataa tttaaataag cgggatggtt acgatgtgga ggtcataaaa      780

agacgaaatg acaatactat tgattgtcat tattttctcc cgatttattg tgatgacatg      840

gagttttaca atgaaatgca ggtatatcac aataatattg tgaagccgga aatgtcagta      900

acattaggat taccaaagag ttaa                                             924


<210> 8
<211> 307
<212> PRT
<213> Yersinia pestis

<400> 8
Met Ile Trp Val Ile Phe Met Leu Lys Gln Met Thr Val Asn Ser Ile 
1               5                   10                  15      


Ile Gln Tyr Ile Glu Glu Asn Leu Glu Ser Lys Phe Ile Asn Ile Asp 
            20                  25                  30          


Cys Leu Val Leu Tyr Ser Gly Phe Ser Arg Arg Tyr Leu Gln Ile Ser 
        35                  40                  45              


Phe Lys Glu Tyr Val Gly Met Pro Ile Gly Thr Tyr Ile Arg Val Arg 
    50                  55                  60                  


Arg Ala Ser Arg Ala Ala Ala Leu Leu Arg Leu Thr Arg Leu Thr Ile 
65                  70                  75                  80  


Ile Glu Ile Ser Ala Lys Leu Phe Tyr Asp Ser Gln Gln Thr Phe Thr 
                85                  90                  95      


Arg Glu Phe Lys Lys Ile Phe Gly Tyr Thr Pro Arg Gln Tyr Arg Met 
            100                 105                 110         


Ile Pro Phe Trp Ser Phe Lys Gly Leu Leu Gly Arg Arg Glu Ile Asn 
        115                 120                 125             


Cys Glu Tyr Leu Gln Pro Arg Ile Cys Tyr Leu Lys Glu Arg Asn Ile 
    130                 135                 140                 


Ile Gly Gln Cys Phe Asn Phe Arg Asp Leu Val Phe Tyr Ser Gly Ile 
145                 150                 155                 160 


Asp Ser Lys Cys Arg Leu Gly Lys Leu Tyr Asp Ser Leu Lys Lys Asn 
                165                 170                 175     


Thr Ala Ile Thr Val Ser Asn Arg Ile Pro Phe His Asp Lys Thr Asn 
            180                 185                 190         


Asp Ile Ile Ala Arg Thr Val Val Trp Asp Arg Asn Lys His Phe Ser 
        195                 200                 205             


Asp Ser Glu Ile Lys Val Asp Lys Gly Leu Tyr Ala Tyr Phe Phe Phe 
    210                 215                 220                 


Asn Asp Thr Tyr Asp Gln Tyr Val His His Met Tyr Asn Ile Tyr Tyr 
225                 230                 235                 240 


Asn Ser Leu Pro Ile Tyr Asn Leu Asn Lys Arg Asp Gly Tyr Asp Val 
                245                 250                 255     


Glu Val Ile Lys Arg Arg Asn Asp Asn Thr Ile Asp Cys His Tyr Phe 
            260                 265                 270         


Leu Pro Ile Tyr Cys Asp Asp Met Glu Phe Tyr Asn Glu Met Gln Val 
        275                 280                 285             


Tyr His Asn Asn Ile Val Lys Pro Glu Met Ser Val Thr Leu Gly Leu 
    290                 295                 300                 


Pro Lys Ser 
305         


<210> 9
<211> 1437
<212> DNA
<213> Yersinia pestis

<400> 9
atggcagatt taactgcaag caccactgca acggcaactc ttgttgaacc agcccgcatc       60

actcttacat ataaggaagg cgctccaatt acaattatgg acaatggaaa catcgataca      120

gaattacttg ttggtacgct tactcttggc ggctataaaa caggaaccac tagcacatct      180

gttaacttta cagatgccgc gggtgatccc atgtacttaa catttacttc tcaggatgga      240

aataaccacc aattcactac aaaagtgatt ggcaaggatt ctagagattt tgatatctct      300

cctaaggtaa acggtgagaa ccttgtgggg gatgacgtcg tcttggctac gggcagccag      360

gatttctttg ttcgctcaat tggttccaaa ggcggtaaac ttgcagcagg taaatacact      420

gatgctgtaa ccgtaaccgt atctaaccaa gaattcatga ttagagccta cgaacaaaac      480

ccacaacatt ttattgagga tctagaaaaa gttagggtgg aacaacttac tggtcatggt      540

tcttcagttt tagaagaatt ggttcagtta gtcaaagata aaaatataga tatttccatt      600

aaatatgatc ccagaaaaga ttcggaggtt tttgccaata gagtaattac tgatgatatc      660

gaattgctca agaaaatcct agcttatttt ctacccgagg atgccattct taaaggcggt      720

cattatgaca accaactgca aaatggcatc aagcgagtaa aagagttcct tgaatcatcg      780

ccgaatacac aatgggaatt gcgggcgttc atggcagtaa tgcatttctc tttaaccgcc      840

gatcgtatcg atgatgatat tttgaaagtg attgttgatt caatgaatca tcatggtgat      900

gcccgtagca agttgcgtga agaattagct gagcttaccg ccgaattaaa gatttattca      960

gttattcaag ccgaaattaa taagcatctg tctagtagtg gcaccataaa tatccatgat     1020

aaatccatta atctcatgga taaaaattta tatggttata cagatgaaga gatttttaaa     1080

gccagcgcag agtacaaaat tctcgagaaa atgcctcaaa ccaccattca ggtggatggg     1140

agcgagaaaa aaatagtctc gataaaggac tttcttggaa gtgagaataa aagaaccggg     1200

gcgttgggta atctgaaaaa ctcatactct tataataaag ataataatga attatctcac     1260

tttgccacca cctgctcgga taagtccagg ccgctcaacg acttggttag ccaaaaaaca     1320

actcagctgt ctgatattac atcacgtttt aattcagcta ttgaagcact gaaccgtttc     1380

attcagaaat atgattcagt gatgcaacgt ctgctagatg acacgtctgg taaatga        1437


<210> 10
<211> 478
<212> PRT
<213> Yersinia pestis

<400> 10
Met Ala Asp Leu Thr Ala Ser Thr Thr Ala Thr Ala Thr Leu Val Glu 
1               5                   10                  15      


Pro Ala Arg Ile Thr Leu Thr Tyr Lys Glu Gly Ala Pro Ile Thr Ile 
            20                  25                  30          


Met Asp Asn Gly Asn Ile Asp Thr Glu Leu Leu Val Gly Thr Leu Thr 
        35                  40                  45              


Leu Gly Gly Tyr Lys Thr Gly Thr Thr Ser Thr Ser Val Asn Phe Thr 
    50                  55                  60                  


Asp Ala Ala Gly Asp Pro Met Tyr Leu Thr Phe Thr Ser Gln Asp Gly 
65                  70                  75                  80  


Asn Asn His Gln Phe Thr Thr Lys Val Ile Gly Lys Asp Ser Arg Asp 
                85                  90                  95      


Phe Asp Ile Ser Pro Lys Val Asn Gly Glu Asn Leu Val Gly Asp Asp 
            100                 105                 110         


Val Val Leu Ala Thr Gly Ser Gln Asp Phe Phe Val Arg Ser Ile Gly 
        115                 120                 125             


Ser Lys Gly Gly Lys Leu Ala Ala Gly Lys Tyr Thr Asp Ala Val Thr 
    130                 135                 140                 


Val Thr Val Ser Asn Gln Glu Phe Met Ile Arg Ala Tyr Glu Gln Asn 
145                 150                 155                 160 


Pro Gln His Phe Ile Glu Asp Leu Glu Lys Val Arg Val Glu Gln Leu 
                165                 170                 175     


Thr Gly His Gly Ser Ser Val Leu Glu Glu Leu Val Gln Leu Val Lys 
            180                 185                 190         


Asp Lys Asn Ile Asp Ile Ser Ile Lys Tyr Asp Pro Arg Lys Asp Ser 
        195                 200                 205             


Glu Val Phe Ala Asn Arg Val Ile Thr Asp Asp Ile Glu Leu Leu Lys 
    210                 215                 220                 


Lys Ile Leu Ala Tyr Phe Leu Pro Glu Asp Ala Ile Leu Lys Gly Gly 
225                 230                 235                 240 


His Tyr Asp Asn Gln Leu Gln Asn Gly Ile Lys Arg Val Lys Glu Phe 
                245                 250                 255     


Leu Glu Ser Ser Pro Asn Thr Gln Trp Glu Leu Arg Ala Phe Met Ala 
            260                 265                 270         


Val Met His Phe Ser Leu Thr Ala Asp Arg Ile Asp Asp Asp Ile Leu 
        275                 280                 285             


Lys Val Ile Val Asp Ser Met Asn His His Gly Asp Ala Arg Ser Lys 
    290                 295                 300                 


Leu Arg Glu Glu Leu Ala Glu Leu Thr Ala Glu Leu Lys Ile Tyr Ser 
305                 310                 315                 320 


Val Ile Gln Ala Glu Ile Asn Lys His Leu Ser Ser Ser Gly Thr Ile 
                325                 330                 335     


Asn Ile His Asp Lys Ser Ile Asn Leu Met Asp Lys Asn Leu Tyr Gly 
            340                 345                 350         


Tyr Thr Asp Glu Glu Ile Phe Lys Ala Ser Ala Glu Tyr Lys Ile Leu 
        355                 360                 365             


Glu Lys Met Pro Gln Thr Thr Ile Gln Val Asp Gly Ser Glu Lys Lys 
    370                 375                 380                 


Ile Val Ser Ile Lys Asp Phe Leu Gly Ser Glu Asn Lys Arg Thr Gly 
385                 390                 395                 400 


Ala Leu Gly Asn Leu Lys Asn Ser Tyr Ser Tyr Asn Lys Asp Asn Asn 
                405                 410                 415     


Glu Leu Ser His Phe Ala Thr Thr Cys Ser Asp Lys Ser Arg Pro Leu 
            420                 425                 430         


Asn Asp Leu Val Ser Gln Lys Thr Thr Gln Leu Ser Asp Ile Thr Ser 
        435                 440                 445             


Arg Phe Asn Ser Ala Ile Glu Ala Leu Asn Arg Phe Ile Gln Lys Tyr 
    450                 455                 460                 


Asp Ser Val Met Gln Arg Leu Leu Asp Asp Thr Ser Gly Lys 
465                 470                 475             


