                         

<110>  Synageva BioPharma Corp.
 
<120>  Avian Derived Fusion Proteins

<130>  SYN-076

<160>  14    

<170>  PatentIn version 3.4

<210>  1
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgGl Fc Fragment

<400>  1

Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 


<210>  2
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4-Fc

<400>  2

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val Ala Gln Pro 
            20                  25                  30          


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
        35                  40                  45              


Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg 
    50                  55                  60                  


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
65                  70                  75                  80  


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
                85                  90                  95      


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
            100                 105                 110         


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
        115                 120                 125             


Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
    130                 135                 140                 


Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             


<210>  3
<211>  11868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSIN-OV-3.5-I-CTLA4-inv Vector

<400>  3
aattgctaga ctaggatccc ccgtgctgca gaaccgagcg gctattgact tcttgctcct     60

agctcacggc catggctgtg aggacattgc gggaatgtgt tgtttcaatc tgagtgatca    120

cagtgagtct atacagaaga agttccagct aatgaaggaa catgtcaata agatcggcgt    180

gaacaacgac ccaatcggaa gttggctgcg aggattattc ggaggaatag gagaatgggc    240

cgtacacttg ctgaaaggac tgcttttggg gcttgtagtt atcttgttgc tagtagtatg    300

cttgccttgc cttttgcaat gtgtatctag tagtattcga aagatgattg ataattcact    360

cggctatcgc gaggaatata aaaaaattac aggaggctta taagcagccc gaaagaagag    420

cgtaggcgag ttcttgtatt ccgtgtgata gctggttgga ttggtaattg atcggctggc    480

acgcggaata taggaggtcg ctgaatagta aacttgtaga cttggctaca gcatagagta    540

tcttctgtag ctctgatgac tgctaggaaa taatgctacg gataatgtgg ggagggcaag    600

gcttgcgaat cgggttgtaa cgggcaaggc ttgactgagg ggacaatagc atgtttaggc    660

gaaaagcggg gcttcggttg tacgcggtta ggagtcccct caggatatag tagtttcgct    720

tttgcatagg gagggggacg gattggacga accactgaat tccgcattgc agagatattg    780

tatttaagtg cctagctcga tacaataaac gccatttgac cattcaccac attggtgtgc    840

acctgggttg atggccggac cgttgattcc ctgrcgacta cgagcacatg catgaagcag    900

aaggcttcat ttggtgaccc cgacgtgatc gttagggaat acgcgctcac tggccgtcgt    960

tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca   1020

tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca   1080

gttgcgcagc ctgaatggcg aatggaaatt gtaagcgtta atattttgtt aaaattcgcg   1140

ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg caaaatccct   1200

tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt   1260

ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat   1320

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca   1380

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac   1440

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta   1500

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg   1560

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata   1620

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga   1680

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca   1740

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat   1800

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag   1860

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc   1920

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct   1980

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca   2040

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt   2100

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat   2160

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt   2220

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta   2280

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga   2340

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt   2400

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc   2460

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct   2520

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata   2580

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt   2640

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc   2700

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg   2760

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact   2820

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg   2880

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg   2940

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac   3000

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca   3060

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga   3120

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc   3180

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct   3240

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg   3300

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct   3360

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc   3420

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc   3480

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat   3540

taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt   3600

aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt   3660

atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat   3720

tacgccaagc gcgcattggt aattgatcgg ctggcacgcg gaatatagga ggtcgctgaa   3780

tagtaaactt gtagacttgg ctacagcata gagtatcttc tgtagctctg atgactgcta   3840

ggaaataatg ctacggataa tgtggggagg gcaaggcttg cgaatcgggt tgtaacgggc   3900

aaggcttgac tgaggggaca atagcatgtt taggcgaaaa gcggggcttc ggttgtacgc   3960

ggttaggagt cccctcagga tatagtagtt tcgcttttgc atagggaggg ggaaatgtag   4020

tcttatgcaa tactcttgta gtcttgcaac atgcttatgt aacgatgagt tagcaacatg   4080

ccttataagg agagaaaaag caccgtgcat gccgattggt gggagtaagg tggtatgatc   4140

gtggtatgat cgtgccttgt taggaaggca acagacgggt ctaacacgga ttggacgaac   4200

cactgaattc cgcattgcag agatattgta tttaagtgcc tagctcgata caataaacgc   4260

catttgacca ttcaccacat tggtgtgcac ctgggttgat ggccggaccg ttgattccct   4320

grcgactacg agcacatgca tgaagcagaa ggcttcattt ggtgaccccg acgtgatcgt   4380

tagggaatag tggtcggcca caggcggcgt ggcgatcctg tcctcatccg tctcgcttat   4440

tcggggagcg gacgatgacc ctagtagagg gggctgcggc ttaggagggc agaagctgag   4500

tggcgtcgga gggagcccta ctgcaggggg ccaacatacc ctaccgagaa ctcagagagt   4560

cgttggaaga cgggaaggaa gcccgacgac tgagcggtcc accccaggcg tgattccggt   4620

tgctctgcgt gattccggtc gcccggtgga tcaagcatgg aagccgtcat aaaggtgatt   4680

tcgtccgcgt gtaagaccta ttgcgggaaa acctctcctt ctaagaagga aataggggct   4740

atgttgtccc tgttacaaaa ggaagggttg cttacgtccc cctcagactt atattccccg   4800

gggtcctggg atcccattac cgcggcgctc tctcagcggg ctatggtact tggaaaatcg   4860

ggagagttaa aaacctgggg attggttttg ggggcattga aggcggctcg agatccggta   4920

ccttcaaata ctacaagtga aaagtgtttg cttaaacatg tttttattat gattaaagga   4980

acaaaagagc acattcacaa gacccattac atatgggtac aaggaaaaca atttgaatag   5040

taatatacca tatttgccaa cataccatga ttgagtcaaa gtttagggag aaatgtgaat   5100

tataagattt ttataatgca tctttaggaa gtcaggaaga gccttgtagt atcaggaaca   5160

cagagaacaa gcaattgcct tgtcagcata ggaatggttg gtgacagttg ataatttaat   5220

ctgagagatt ttgagtgact aattctggag cagcttggtc atacagatat ctggcttaat   5280

tggaaggctg catttttccc ccataaacct tctgctgatg tatcaggttg catttttcag   5340

tgtgatgact cagtactgtg agtccaattt cattccctta agccttcatc catgagttac   5400

cagtattact ctgtgtaaag gaaaagtgaa ttgcacctgt tctcacagtg taatttcttt   5460

ctgatttttt ttctagatta agctccagct tttatgaagt ctggatgcag cagataacat   5520

acttttcatt ttacccctga tactacagtg ctctgggtct tgttggaagg gacagagttt   5580

ttcagctttc ttctttgaat tcctcattta cccggagaca gggagaggct cttctgcgtg   5640

tagtggttgt gcagagcctc atgcatcacg gagcatgaga agacgttccc ctgctgccac   5700

ctgctcttgt ccacggtgag cttgctgtag aggaagaagg agccgtcgga gtccagcacg   5760

ggaggcgtgg tcttgtagtt gttctccggc tgcccattgc tctcccactc cacggcgatg   5820

tcgctgggat agaagccttt gaccaggcag gtcaggctga cctggttctt ggtcagctca   5880

tcccgggatg ggggcagggt gtacacctgt ggttctcggg gctgcccttt ggctttggag   5940

atggttttct cgatgggggc tgggagggct ttgttggaga ccttgcactt gtactccttg   6000

ccattcagcc agtcctggtg caggacggtg aggacgctga ccacccggta cgtgctgttg   6060

tactgctcct cccgcggctt tgtcttggca ttatgcacct ccacgccgtc cacgtaccag   6120

ttgaacttga cctcagggtc ttcgtggctc acgtccacca ccacgcatgt gacctcaggg   6180

gtccgggaga tcatgagggt gtccttgggt tttgggggga agaggaagac tgacgatccc   6240

cccaggagtt caggtgctgg ggacggtggg gatgtgtgag ttttgtcaga agatttgggc   6300

tcctgatcag aatctgggca cggttctgga tcaattacat aaatctgggt tccgttgcct   6360

atgcccaggt agtatggcgg tgggtacatg agctccacct tgcagatgta gagtcccgtg   6420

tccatggccc tcagtccttg gatagtgagg ttcacttgat ttccactgga ggtgcccgtg   6480

cagatggaat catctaggaa ggtcaactca ttccccatca tgtaggttgc cgcacagact   6540

tcagtcacct ggctgtcagc ctgccgaagc actgtcaccc ggacctcagt ggctttgcct   6600

ggagatgcat actcacacac aaagctrgcg atgcctcggc tgctggccag taccacagca   6660

ggctgggcca cgtgcattgc catgctcgcc atgcttggaa acaggagtgc aaggaccaga   6720

ctgagcagcg tcctctgtgt gagcagtaca cccatggtga actctgagtt gtctagagca   6780

aacagcagaa cagtgaaaat gtaaggatgg aatgctgtac atagtaccat gcagggtact   6840

ctatggtagg ctacaacagt aaattacgag cagtttttag gcaattaaat gttaacaagt   6900

agttttaaag taattctgtg gtaatgtgtc tgttgctata tccacctctc atgtgcatgt   6960

tcaaaaccat attcataaat ctatttatgt atttgcattc agttgtcttt tgggtagcaa   7020

actgtcccag aagccagttg cctctacata tttttgttca gtgaaagcta gaattcattg   7080

atacttttca gtacctctga ttaaaacaca atctgatagg cttgcaaaac tggaaattca   7140

aagagcaaat ttcagtaaac tttaggtttg gacagatata tgagaaagca gaggcttgct   7200

gactatttta tttcttattt ttattcccta aaaataaatg tagagaaata tctgtttgtt   7260

gcacactact tgctatgagt agatcttcaa aagtattttt acctttgttt tggtgatggc   7320

agaatagata aggaatgtaa tttatatggg gtcatgtagt ctaggagaaa gacacgcatg   7380

taattcatat tctgctctat tgcactttca ggtatggttt gctttgctca aagatatgca   7440

tgtgtactgt agtataaact ttctgtggag ttaaatttta gtggtgacat tcagacagaa   7500

gagaaatgca gacatgataa aatagcaatg tttactataa aacagagcca ctgaatgaat   7560

tcttgttcat gacatagacc aatagaagat ttatacttgt tctgtctgtt tctattataa   7620

agagctgaac tgtacaacta ttgtatagcc agtgtgctta tataaagcac agcttttgga   7680

gccagcatga atctagttgc tttcctgaga tttatataat ctgtgaaagt cagaagtcct   7740

tcagagccca gccctttata tgcgtactga gtgctggggc ctcaggattg gattttctgt   7800

attaaacccc tcaaaagttt ttactgacca cgtgtgtgag tatacacaca cacatttttc   7860

tcattttctt ttctgtatat aagttcacat gtatctatta ttgtaagaat atacgtttat   7920

gcacccccca catttttatc ttgtgtagtg atcagcagct gcactttgca ggaattaaac   7980

ttctagagaa ttttcacatt aaaataactc cccagaattc actgaacacc atgattttgc   8040

tctctgtgca ctctgtaggg ctagaagtta atcaagcaaa ctgcaaagca tatcagatag   8100

tgaacgacag gataagatgt tctgaaatta aaaacatatt ttaagcacaa agaataagcc   8160

tcctgaaaac aaacacaaag cttttacaca taataaaata gtgcagaatg catacacagg   8220

tgagaagttt ttataggggg tatcacgcag gtacttcacc cttaaagata caacacatag   8280

cacaataatt gttaattttt taaagtttag gtgcaagtaa gagctaatat agagagaagg   8340

taattccaga gagttgctta cctttcgagc ttgactgcta aaggcaatac agctttctag   8400

ctgtatgtac agacactggc tgagccctgg ggaatatata gtctgaattg tgacccaccc   8460

acaggttccc ttcagaagtt tgacctttga caccatagaa atcatttaat gggattgggt   8520

tagattttag tttcaatagg tccattttgg attgaatgga gagcaaatat tagtttttaa   8580

ttctgggtaa caatgtgttt tctgcctgtt ctgctaatcc atcaggactg ttggatggga   8640

gagaagactg ggaaatattg ctcatgttcc attgagcttc agttacaacc agataatggg   8700

atctttaaga aaacagaaaa atgtgggaac cttggagatg gaaaacataa ttagcaatta   8760

ttagttagtg tgcttattac tatggttgta gtaacagacc agaagtctgt ttcatttgat   8820

ccttcttgta tgtacaatgt gcatctgagc cacgctagac aggacataaa tgagaacaag   8880

acttgaccta ttattttctt gacaaaatag gagaaataaa gaagcgtgca tgtgaaggag   8940

ccaactgaga ctagagtgaa gagcagacac actttctttc ctatagttgg aatatttaaa   9000

tctatctttt tatgggtgtg aatgctttat aacaaacttt tattctgagg atacagcaaa   9060

acatagctcc atacaatgca aaacaatact caatttcaaa tgtgtttatg atatgaactt   9120

gcagtgttcc tcaaagatct tccatgaata acttaatggc ctggcagatg acagaggaat   9180

tgtgaaattc agctggagga gtgttcatgg ttcgagggac aatcataata tacaatagca   9240

aatatatttc agttatagaa gctattgttc tgtattgaaa taatagaatt gacaaacagt   9300

aaagaaacca ttctgacctc tgtaaagcac tgtttgattt aaaaatgggg gaaaaaagta   9360

caacataatt cttcaggaca tacatagaga tcactgcaat ctctgttaag cagaattact   9420

ttcctatacc actagctgaa gtttagtcag tgccattttc ttttgtttct ctccttcctt   9480

ttgtgaaaac atatatactg tggaaatcta cattctcctt gccaagtctg aggacttaag   9540

acaagatggt agtgcaaata atattttttt gctggatgtc tacaccacag gtatcaactg   9600

attttttttg tttcattttg tttttaatca cgtcttttgc ttctatttca gccactaaga   9660

aagtctgaaa atcttgcctg ctttttgtga tgatagatgt gcttcccagt aaatgttatc   9720

tctacctatg aaatgcatgt cagtctgcag aaagagaaag gagattggga ataggttttc   9780

tcagatgcac ttctctgtca tctggtgtca atcaaacact aataatttgt gtatagatat   9840

cttatatata tatatatatt tggaatttgc aggttggcat agttcagata gtcctgtcac   9900

attgtaatat cctggtgaga taacaaggaa aagagagacc gtttcggctc ttactaaggc   9960

agggaactgc ttaccagaca gggaggttct ggagatgaca tccagcatga aaagcacact  10020

tccaaatact taaaggtatc aagtctaact tgtcagacag gctccagaat aacttctgtc  10080

ctaatgctac agaaaagggg gaaggtatcc accatggcca aaattgtcag ccattttgtc  10140

tcagcaaaca gcagatctgg tcagtaagga caagattctt ccaaagcaac catgccatat  10200

ataattaagc atgtgtaatt aattaataaa aaatataatt tagtgtattt cctcctttgg  10260

atgttatgaa gaaatgcttt tattaacaat tcaccataat ctgtcctaag agtagtgaat  10320

aacaacaggc tgcttctcac cctgtggttg ggtgtaccag tgagccagag ctaaacgcca  10380

cgtttcctct tttgtatccc atagcagaga gggtctccat ttcatttctg tagctcagaa  10440

agttgtagtg gatttacact acaagttgtg gtagtggagg tctgccggag tggcctctgt  10500

gaacagagcc cagcagctgt cccgtgtcct caaaagggag ctgccactgg ccagagctga  10560

gccagtgatc gatgctagat gtacctcagg aggagcaata tgtaagaaca actgctgtac  10620

aatggtagtt gggagaggtg agtgagaaaa tgtgagagaa acagccctga tgacactgag  10680

gtcagtgcgg aggagggcag gaggtgttcc aggtgtagaa cagaagttcc ctgcagccca  10740

agagaggccc atggtggagc actctgaccc tctgcagccc atggtatatc atataaacct  10800

cagttctgtg acattatttt aactccatat cccttttctg ttcagggtca ctttgagttc  10860

acagccattt ctttatattt ctccaatatc agccttccat tgctacatat gagacttgga  10920

cagtacatct gattcagtca aatctgcctt cagaacgtcc ctgaagccct tcttagacag  10980

tctcaattct ccttcccttc atctctttta tcatacatgg accacggacc tgtccagacc  11040

tgagtcatat gtccatcttt acgtccatct ctatgtcttg tactttaaga caaataaaat  11100

atcaaggaaa ttgatgcagt tatgtcagtt atcactgtca tagtatcgtg ctgcaaatat  11160

aagatgagaa tgatcccaaa ggctttttaa agctgctcta tttgacttcc acatagtgtc  11220

ctgattccag acctacagaa cagttttgta tgcatttgac ttgcagagct ttgttttgtg  11280

agtcttataa aagccatttt tcctctccaa gaagtagccg gtggtttaaa acaatgtaga  11340

ttaagtgtgg agcatgagaa tttctgcttt tctgtcagat gagaaggata tactacactc  11400

tttcccaatg gaagaccagc tgcaagcaac aaaaattgtc catgaacaaa tgagatcttg  11460

atcagaacag gctgtcatca tagtgttgtc agcatacctg catagttggt ttgacttggg  11520

ggtctagaga gagtaagcaa caatcttctt gcagttggaa ggttacctgg gataggtggc  11580

aatggattgc cctgcccagc acagctgtgc aaagcagtac aaatagtttt gtcacacatt  11640

gtttgacaat gcttgtccca agaaaaggtc agctaaggct ctgctgccct ttcctatgcc  11700

aggcatttca ttgtgggtct gtccctaaac caacagtctc atgaataaag actcggagac  11760

ctgaaagtta taaaagcact ttttatccaa aaggatatga agtccaggtg agctcacagg  11820

tcaaagcctc ttatccaatc actaaaacct actcagaact tgactcga               11868


<210>  4
<211>  10021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSIN-3.9-OM-CTLA4-Fc Vector

<400>  4
ctagactagg atcccccgtg ctgcagaacc gagcggctat tgacttcttg ctcctagctc     60

acggccatgg ctgtgaggac attgcgggaa tgtgttgttt caatctgagt gatcacagtg    120

agtctataca gaagaagttc cagctaatga aggaacatgt caataagatc ggcgtgaaca    180

acgacccaat cggaagttgg ctgcgaggat tattcggagg aataggagaa tgggccgtac    240

acttgctgaa aggactgctt ttggggcttg tagttatctt gttgctagta gtatgcttgc    300

cttgcctttt gcaatgtgta tctagtagta ttcgaaagat gattgataat tcactcggct    360

atcgcgagga atataaaaaa attacaggag gcttataagc agcccgaaag aagagcgtag    420

gcgagttctt gtattccgtg tgatagctgg ttggattggt aattgatcgg ctggcacgcg    480

gaatatagga ggtcgctgaa tagtaaactt gtagacttgg ctacagcata gagtatcttc    540

tgtagctctg atgactgcta ggaaataatg ctacggataa tgtggggagg gcaaggcttg    600

cgaatcgggt tgtaacgggc aaggcttgac tgaggggaca atagcatgtt taggcgaaaa    660

gcggggcttc ggttgtacgc ggttaggagt cccctcagga tatagtagtt tcgcttttgc    720

atagggaggg ggacggattg gacgaaccac tgaattccgc attgcagaga tattgtattt    780

aagtgcctag ctcgatacaa taaacgccat ttgaccattc accacattgg tgtgcacctg    840

ggttgatggc cggaccgttg attccctgrc gactacgagc acatgcatga agcagaaggc    900

ttcatttggt gaccccgacg tgatcgttag ggaatacgcg ctcactggcc gtcgttttac    960

aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc   1020

ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc   1080

gcagcctgaa tggcgaatgg aaattgtaag cgttaatatt ttgttaaaat tcgcgttaaa   1140

tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa   1200

atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact   1260

attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc   1320

actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa   1380

tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc   1440

gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt   1500

cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtcagg   1560

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc   1620

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag   1680

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg   1740

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt   1800

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt   1860

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt   1920

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa   1980

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag   2040

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac   2100

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac   2160

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac   2220

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac   2280

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact   2340

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg   2400

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt   2460

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat   2520

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta   2580

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa   2640

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga   2700

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac   2760

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt   2820

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc   2880

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat   2940

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag   3000

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc   3060

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag   3120

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac   3180

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg   3240

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct   3300

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc   3360

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga   3420

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga   3480

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg   3540

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt   3600

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt   3660

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc   3720

caagcgcgca ttggtaattg atcggctggc acgcggaata taggaggtcg ctgaatagta   3780

aacttgtaga cttggctaca gcatagagta tcttctgtag ctctgatgac tgctaggaaa   3840

taatgctacg gataatgtgg ggagggcaag gcttgcgaat cgggttgtaa cgggcaaggc   3900

ttgactgagg ggacaatagc atgtttaggc gaaaagcggg gcttcggttg tacgcggtta   3960

ggagtcccct caggatatag tagtttcgct tttgcatagg gagggggaaa tgtagtctta   4020

tgcaatactc ttgtagtctt gcaacatgct tatgtaacga tgagttagca acatgcctta   4080

taaggagaga aaaagcaccg tgcatgccga ttggtgggag taaggtggta tgatcgtggt   4140

atgatcgtgc cttgttagga aggcaacaga cgggtctaac acggattgga cgaaccactg   4200

aattccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgccattt   4260

gaccattcac cacattggtg tgcacctggg ttgatggccg gaccgttgat tccctgrcga   4320

ctacgagcac atgcatgaag cagaaggctt catttggtga ccccgacgtg atcgttaggg   4380

aatagtggtc ggccacaggc ggcgtggcga tcctgtcctc atccgtctcg cttattcggg   4440

gagcggacga tgaccctagt agagggggct gcggcttagg agggcagaag ctgagtggcg   4500

tcggagggag ccctactgca gggggccaac ataccctacc gagaactcag agagtcgttg   4560

gaagacggga aggaagcccg acgactgagc ggtccacccc aggcgtgatt ccggttgctc   4620

tgcgtgattc cggtcgcccg gtggatcaag catggaagcc gtcataaagg tgatttcgtc   4680

cgcgtgtaag acctattgcg ggaaaacctc tccttctaag aaggaaatag gggctatgtt   4740

gtccctgtta caaaaggaag ggttgcttac gtccccctca gacttatatt ccccggggtc   4800

ctgggatccc attaccgcgg cgctctctca gcgggctatg gtacttggaa aatcgggaga   4860

gttaaaaacc tggggattgg ttttgggggc attgaaggcg gctcgaggtc gacggtatcg   4920

ataagcttgc agtccaaggc tttgtctgtg tacccagtga aatccttcct ctgttacata   4980

aagcccagat aggactcaga aatgtagtca ttccagcccc cctcttcctc agatctggag   5040

cagcacttgt ttgcagccag tcctccccaa aatgcacaga cctcgccgag tggagggaga   5100

tgtaaacagc gaaggttaat tacctccttg tcaaaaacac tttgtggtcc atagatgttt   5160

ctgtcaatct tacaaaacag aaccgagagg cagcgagcac tgaagagcgt gttcccatgc   5220

tgagttaatg agacttggca gctcgctgtg cagagatgat ccctgtgctt catgggaggc   5280

tgtaacctgt ctccccatcg ccttcacacc gcagtgctgt cctggacacc tcaccctcca   5340

taagctgtag gatgcagctg cccagggatc aagagacttt tcctaaggct cttaggactc   5400

atctttgccg ctcagtagcg tgcagcaatt actcatccca actatactga atgggtttct   5460

gccagctctg cttgtttgtc aataagcatt tcttcatttt gcctctaagt ttctctcagc   5520

agcaccgctc tgggtgacct gagtggccac ctggaacccg aggggcacag ccaccacctc   5580

cctgttgctg ctgctccagg gactcatgtg ctgctggatg gggggaagca tgaagttcct   5640

cacccagaca cctgggttgc aatggctgca gcgtgctctt cttggtatgc agattgtttc   5700

cagccattac ttgtagaaat gtgctgtgga agccctttgt atctctttct gtggcccttc   5760

agcaaaagct gtgggaaagc tctgaggctg ctttcttggg tcgtggagga attgtatgtt   5820

ccttctttaa caaaaattat ccttaggaga gagcactgtg caagcattgt gcacataaaa   5880

caattcaggt tgaaagggct ctctggaggt ttccagcctg actactgctc gaagcaaggc   5940

caggttcaaa gatggctcag gatgctgtgt gccttcctga ttatctgtgc caccaatgga   6000

ggagattcac agccactctg cttcccgtgc cactcatgga gaggaatatt cccttatatt   6060

cagatagaat gttatccttt agctcagcct tccctataac cccatgaggg agctgcagat   6120

ccccatactc tccccttctc tggggtgaag gccgtgtccc ccagcccccc ttcccaccct   6180

gtgccctaag cagcccgctg gcctctgctg gatgtgtgcc tatatgtcaa tgcctgtcct   6240

tgcagtccag cctgggacat ttaattcatc accagggtaa tgtggaactg tgtcatcttc   6300

ccctgcaggg tacaaagttc tgcacggggt cctttcggtt caggaaaacc ttcactggtg   6360

ctacctgaat caagctctat ttaataagtt cataagcaca tggatgtgtt ttcctagaga   6420

tacgttttaa tggtatcagt gatttttatt tgctttgttg cttacttcaa acagtgcctt   6480

tgggcaggag gtgagggacg ggtctgccgt tggctctgca gtgatttctc caggcgtgtg   6540

gctcaggtca gatagtggtc actctgtggc cagaagaagg acaaagatgg aaattgcaga   6600

ttgagtcacg ttaagcaggc atcttggagt gatttgaggc agtttcatga aagagctacg   6660

accacttatt gttgttttcc ccttttacaa cagaagtttt catcaaaata acgtggcaaa   6720

gcccaggaat gtttgggaaa agtgtagtta aatgttttgt aattcatttg tcggagtgct   6780

accagctaag aaaaaagtcc tacctttggt atggtagtcc tgcagagaat acaacatcaa   6840

tattagtttg gaaaaaaaca ccaccaccac cagaaactgt aatggaaaat gtaaaccaag   6900

aaattccttg ggtaagagag aaaggatgtc gtatactggc caagtcctgc ccagctgtca   6960

gcctgctgac cctctgcagt tcaggaccat gaaacgtggc actgtaagac gtgtcccctg   7020

cctttgcttg cccacagatc tctgcccttg tgctgactcc tgcacacaag agcatttccc   7080

tgtagccaaa cagcgattag ccataagctg cacctgactt tgaggattaa gagtttgcaa   7140

ttaagtggat tgcagcagga gatcagtggc agggttgcag atgaaatcct tttctagggg   7200

tagctaaggg ctgagcaacc tgtcctacag cacaagccaa accagccaag ggttttcctg   7260

tgctgttcac agaggcaggg ccagctggag ctggaggagg ttgtgctggg acccttctcc   7320

ctgtgctgag aatggagtga tttctgggtg ctgttcctgt ggcttgcact gagcagctca   7380

agggagatcg gtgctcctca tgcagtgcca aaactcgtgt ttgatgcaga aagatggatg   7440

tgcacctccc tcctgctaat gcagccgtga gcttatgaag gcaatgagcc ctcagtgcag   7500

caggagctgt agtgcactcc tgtaggtgct agggaaaatc tctggttccc agggatgcat   7560

tcataagggc aatatatctt gaggctgcgc caaatctttc tgaaatattc atgcgtgttc   7620

ccttaattta tagaaacaaa cacagcagaa taattattcc aatgcctccc ctcgaaggaa   7680

acccatattt ccatgtagaa atgtaaccta tatacacaca gccatgctgc atccttcaga   7740

acgtgccagt gctcatctcc catggcaaaa tactacaggt attctcacta tgttggacct   7800

gtgaaaggaa ccatggtaag aaacttcggt taaaggtatg gctgcaaaac tactcatacc   7860

aaaacagcag agctccagac ctcctcttag gaaagagcca cttggagagg gatggtgtga   7920

aggctggagg tgagagacag agcctgtccc agttttcctg tctctatttt ctgaaacgtt   7980

tgcaggagga aaggacaact gtactttcag gcatagctgg tgccctcacg taaataagtt   8040

ccccgaactt ctgtgtcatt tgttcttaag atgctttggc agaacacttt gagtcaattc   8100

gcttaactgt gactaggtct gtaaataagt gctccctgct gataaggttc aagtgacatt   8160

tttagtggta tttgacagca tttaccttgc tttcaagtct tctaccaagc tcttctatac   8220

ttaagcagtg aaaccgccaa gaaacccttc cttttatcaa gctagtgcta aataccatta   8280

acttcatagg ttagatacgg tgctgccagc ttcacctggc agtggttggt cagttctgct   8340

ggtgacaaag cctccctggc ctgtgctttt acctagaggt gaatatccaa gaatgcagaa   8400

ctgcatggaa agcagagctg caggcacgat ggtgctgagc cttagctgct tcctgctggg   8460

agatgtggat gcagagacga atgaaggacc tgtcccttac tcccctcagc attctgtgct   8520

atttagggtt ctaccagagt ccttaagagg tttttttttt ttttggtcca aaagtctgtt   8580

tgtttggttt tgaccactga gagcatgtga cacttgtctc aagctattaa ccaagtgtcc   8640

agccaaaatc aattgcctgg gagacgcaga ccattacctg gaggtcagga cctcaataaa   8700

tattaccagc ctcattgtgc cgctgacaga ttcagctggc tgctccgtgt tccagtccaa   8760

cagttcggac gccacgtttg tatatatttg caggcagcct cggggggacc atctcaggag   8820

cagagcaccg gcagccgcct gcagagccgg gcagtacctc aacatgggtg tactgctcac   8880

acagaggacg ctgctcagtc tggtccttgc actcctgttt ccaagcatgg cgagcatggc   8940

aatgcacgtg gcccagcctg ctgtggtact ggccagcagc cgaggcatcg cyagctttgt   9000

gtgtgagtat gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc   9060

tgacagccag gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt   9120

cctagatgat tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca   9180

aggactgagg gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc   9240

gccatactac ctgggcatag gcaacggaac ccagatttat gtaattgatc cagaaccgtg   9300

cccagattct gatcaggagc ccaaatcttc tgacaaaact cacacatccc caccgtcccc   9360

agcacctgaa ctcctggggg gatcgtcagt cttcctcttc cccccaaaac ccaaggacac   9420

cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga   9480

ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa   9540

gccgcgggag gagcagtaca acagcacgta ccgggtggtc agcgtcctca ccgtcctgca   9600

ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc   9660

ccccatcgag aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac   9720

cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa   9780

aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa   9840

ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct   9900

caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga   9960

ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggta aatgaggaat  10020

t                                                                  10021


<210>  5
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human lysosomal acid lipase

<400>  5

Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu Thr Asn Met Asn Val 
1               5                   10                  15      


Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val 
            20                  25                  30          


Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly 
        35                  40                  45              


Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln 
    50                  55                  60                  


His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met 
                85                  90                  95      


Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser 
            100                 105                 110         


Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys 
        115                 120                 125             


Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln 
    130                 135                 140                 


Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe 
145                 150                 155                 160 


Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe 
                165                 170                 175     


Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met 
            180                 185                 190         


Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly 
        195                 200                 205             


Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr 
    210                 215                 220                 


His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys 
225                 230                 235                 240 


Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val 
                245                 250                 255     


Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met 
            260                 265                 270         


Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp 
        275                 280                 285             


Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro 
    290                 295                 300                 


Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser 
305                 310                 315                 320 


Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu 
                325                 330                 335     


Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu 
            340                 345                 350         


His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn 
        355                 360                 365             


Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
    370                 375             


<210>  6
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human glucocerebrosidase

<400>  6

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26 Primer-1

<400>  7
gcggaattca aagaagaaag ctgaaaaac                                       29


<210>  8
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26 Primer-2

<400>  8
gcgggtacct tcaaatacta caagtgaaa                                       29


<210>  9
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26-OV Primer 1

<400>  9
ggcctcgagt caagttctga gtaggtttta gtg                                  33


<210>  10
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26-OV Primer 2

<400>  10
gcgcgtctct gtctagagca aacagcagaa cagtgaaaat g                         41


<210>  11
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4-Fc Primer 1

<400>  11
gcgcgtctca agacaactca gagttcacca tgggtgtact gctcacacag                50


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4-Fc Primer 2

<400>  12
ggcccgggag ttttgtcaga agatttggg                                       29


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence Peptides

<400>  13

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly 
            20      


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence Peptides

<400>  14

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly 
        35                  


