                         SEQUENCE LISTING

<110>  El-Andalussi, Samir
       Johansson, Henrik
       Langel, Ulo
       Lundin Per
       Rosenthal-Aizman, Katri
       Tedebark, Ulf
       Lindgren, Maria
       Hallbrink, Mattias
       Sillard, Rannar
       Lehto, Taavi
       Mger, Imhre
       Guterstam, Peter
       Ezzat, Karim
 
<120>  Chemically modified cell penetrating peptides for improved 
       delivery of gene modulating compunds

<130>  221658

<160>  28    

<170>  PatentIn version 3.4

<210>  1
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (10)..(11)
<223>  X is Ornithine

<220>
<221>  X
<222>  (18)..(19)
<223>  X is Ornithine

<400>  1

Ala Gly Tyr Leu Leu Gly Lys Leu Leu Xaa Xaa Leu Ala Ala Ala Ala 
1               5                   10                  15      


Leu Xaa Xaa Leu Leu 
            20      


<210>  2
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  3
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (9)..(9)
<223>  X is 6-amino hexanoic acid

<220>
<221>  X
<222>  (12)..(12)
<223>  X is 6-amino hexanoic acid

<220>
<221>  X
<222>  (15)..(15)
<223>  X is 6-amino hexanoic acid

<220>
<221>  X
<222>  (18)..(18)
<223>  X is 6-amino hexanoic acid

<400>  3

Arg Lys Lys Arg Lys Lys Lys Arg Xaa Arg His Xaa Arg His Xaa Arg 
1               5                   10                  15      


His Xaa Arg 
            


<210>  4
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  5
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (9)..(9)
<223>  X is 6-amino hexanoic acid

<220>
<221>  X
<222>  (12)..(12)
<223>  X is 6-amino hexanoic acid

<220>
<221>  X
<222>  (15)..(15)
<223>  X is 6-amino hexanoic acid

<220>
<221>  X
<222>  (18)..(18)
<223>  X is 6-amino hexanoic acid

<400>  5

Arg Lys Lys Arg Lys Lys Lys His Xaa His His Xaa His His Xaa His 
1               5                   10                  15      


His Xaa His 
            


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (3)..(4)
<223>  X is Ornithine

<220>
<221>  X
<222>  (11)..(12)
<223>  X is Ornithine

<400>  6

Leu Leu Xaa Xaa Leu Ala Ala Ala Ala Leu Xaa Xaa Leu Leu 
1               5                   10                  


<210>  7
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  9
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  10
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  11
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Phe Ile Leu Phe Ile Leu Phe Ile Leu Gly Gly Lys His Lys His Lys 
1               5                   10                  15      


His Lys His Lys His Lys 
            20          


<210>  12
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Phe Ile Leu Phe Ile Leu Phe Ile Leu Gly Lys Gly Lys His Lys His 
1               5                   10                  15      


Lys His Lys His Lys His Lys 
            20              


<210>  13
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Phe Ile Leu Phe Ile Leu Phe Ile Leu Gly Lys Gly Lys His Arg His 
1               5                   10                  15      


Lys His Arg His Lys His Arg 
            20              


<210>  14
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  15
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Gly Asp Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu 
1               5                   10                  15      


Arg Gly Arg Gly Ser Thr Leu 
            20              


<210>  16
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Gly Ser Thr Leu 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Pro Phe Leu Asn Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Gly Ser Thr Leu 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Pro Phe Leu Asp Arg Leu Arg Arg Asn Gln Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Gly Ser Thr Leu 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Pro Phe Leu Asn Arg Leu Arg Arg Asn Gln Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Gly Ser Thr Leu 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Pro Phe Leu Asn Arg Leu Arg Arg Asn Leu Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Leu Ser Thr Leu 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Pro Phe Leu Asp Arg Lys Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Gly Ser Thr Leu 
            20  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Arg His Arg His Arg His His His Gly Gly Pro Phe Leu Asp Arg Leu 
1               5                   10                  15      


Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg Gly Ser Thr Leu 
            20                  25                  30  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Pro Asn Asn Val Arg Arg Asp Leu Asp Asn Leu His Ala Cys Leu Asn 
1               5                   10                  15      


Lys Ala Lys Leu Thr Val Ser Arg Met Val Thr Ser Leu Leu Glu Lys 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Pro Asn Asn Val Arg Arg Asp Leu Asp Asn Leu His Ala Met Leu Asn 
1               5                   10                  15      


Lys Ala Lys Leu Thr Val Ser Arg Met Val Thr Ser Leu Leu Glu Lys 
            20                  25                  30          


<210>  25
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Pro Asn Asn Val Arg Arg Asp Leu Asn Asn Leu His Ala Met Leu Asn 
1               5                   10                  15      


Lys Ala Lys Leu Thr Val Ser Arg Met Val Thr Ser Leu Leu Gln Lys 
            20                  25                  30          


<210>  26
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Pro Phe Leu Asn Arg Leu Arg Arg Asn Leu Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Leu Ser Thr Leu 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Pro Phe Leu Asn Arg Lys Arg Arg Asn Leu Lys Ser Leu Arg Gly Arg 
1               5                   10                  15      


Leu Ser Thr Leu 
            20  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
1               5                   10                  





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