                         SEQUENCE LISTING



<110>  Zirus, Inc.

       Vanderbilt University

 

<120>  MAMMALIAN GENES INVOLVED IN INFECTION



<130>  01123.0014P1



<150>  US 61/194.774

<151>  2008-09-30



<150>  US 61/195,770

<151>  2008-10-09



<160>  2259  



<170>  PatentIn version 3.5



<210>  1

<211>  4406

<212>  DNA

<213>  Homo sapiens



<400>  1

cggtgcggag cctgtctcct tcactggatc ccgcattttc agcgcgttgc atcacctccg       60



tgcgcccggt tgcagcgtgg acgccggatg agttgctttt aggcttgctg gcccgcgggg      120



ctgtccaggc acgcgaggcc cctcagcaac aaaatgcttc aacaagttcc agaaaacata      180



aattttcctg ctgaagaaga gaaaatcttg gagttttgga ctgaatttaa ttgttttcag      240



gaatgcttaa agcaatcaaa acataaacca aaatttacct tctatgatgg tcctcctttt      300



gcaactggac tgcctcacta tggacatata cttgcgggta caattaaaga tatagttaca      360



agatatgctc accagagtgg gtttcatgtt gacagaagat ttggatggga ttgccatggc      420



ttacctgtgg aatatgaaat tgataagaca ctgggaatca gaggaccaga ggatgtggcc      480



aaaatgggga ttacagagta taacaatcag tgccgagcaa ttgtgatgag atattctgct      540



gagtggaagt ctactgttag cagacttggc cgatggattg actttgacaa tgactataaa      600



actctgtatc cacaattcat ggaatcagtc tggtgggtct tcaaacaact ctatgataaa      660



ggccttgttt atagaggtgt gaaagtcatg cccttctcta cggcatgtaa cactccactt      720



tccaacttcg agtcacacca gaattataag gatgttcaag atccttcagt atttgtaact      780



ttccctttgg aagaagatga aactgtatct ttagttgctt ggacaaccac tccctggact      840



ctacctagta accttgctgt gtgtgttaat ccagaaatgc aatatgtgaa aattaaagat      900



gttgccagag gacgattact cattttaatg gaagccagat tgtcagccct ctataaattg      960



gagagtgact atgagatcct tgaaagattt cctggtgcct atcttaaagg caagaagtac     1020



aggcccctgt ttgactattt cctgaagtgt aaagagaatg gcgctttcac tgtgcttgtt     1080



gacaactatg tgaaggaaga agaaggcaca ggggttgtcc accaagctcc ttacttcggt     1140



gctgaggact atcgggtctg tatggacttt aacattattc ggaaagactc actccctgtt     1200



tgccctgtgg atgcttcagg ctgcttcaca acggaggtga cagatttcgc aggacagtat     1260



gtgaaggatg ctgacaaaag tatcatcagg actttgaagg aacaaggccg acttctggtt     1320



gccaccacct tcactcacag ctaccctttt tgctggagat cagacactcc tctaatttac     1380



aaagcagtgc ccagctggtt tgtgcgagtg gagaacatgg tggaccagct cctaaggaac     1440



aatgacctgt gctactgggt cccagagttg gtacgagaaa aacgatttgg aaattggctg     1500



aaagatgcac gtgactggac aatttccaga aacagatact ggggcacccc catcccactg     1560



tgggtcagcg atgactttga ggaggtggta tgcattgggt cagtggcgga acttgaagaa     1620



ctgtcaggag caaagatctc agatctccac agagagagtg ttgaccacct gaccattcct     1680



tcacgctgtg ggaagggatc cttgcaccgc atctctgaag tgtttgactg ttggtttgag     1740



agtggcagca tgccctatgc tcaggttcat tacccgtttg aaaacaagag ggagtttgag     1800



gatgcttttc ctgcagattt cattgccgag ggcatcgacc aaaccagagg atggttttat     1860



accctgctgg tgctggccac ggccctcttt ggacaaccgc ctttcaagaa cgtaattgtg     1920



aatgggcttg tcctggcaag tgatggccaa aaaatgagca aacggaaaaa gaattatcca     1980



gatccagttt ccatcatcca gaagtatggt gctgatgccc tcagattata tctgattaac     2040



tcccctgtgg tgagagcaga aaacctccgc tttaaagaag agggtgtgcg ggacgtcctt     2100



aaggatgtac tgctcccatg gtacaatgcc tatcgcttct taatccagaa cgttctgagg     2160



ctccagaagg aggaagaaat agaatttctc tacaatgaga acacggttag agaaagcccc     2220



aacattacag accggtggat cctgtccttc atgcagtctc tcattggctt ctttgagact     2280



gaaatggcag cttataggct ttatactgtg gtgcctcgcc tggtcaagtt tgtagatatt     2340



ctgaccaatt ggtatgttag aatgaaccgc agaagattaa agggtgaaaa tgggatggag     2400



gattgtgtca tggccctaga aaccttgttt agtgttctgc tttctctttg cagacttatg     2460



gctccctaca caccttttct cactgaattg atgtaccaga atctaaaggt gctgattgac     2520



cctgtttctg ttcaggacaa ggacacactc agcattcact acctcatgct gccccgtgtt     2580



cgagaagaat tgattgacaa gaaaacagag agtgcagtat ctcagatgca gtctgtgatt     2640



gaacttggaa gagtgatcag agaccgaaaa actattccca taaagtatcc tttgaaagaa     2700



attgtggtta tccatcaaga tccagaagct cttaaagata tcaagtcttt ggagaagtat     2760



atcattgagg aactcaatgt tcgaaaagtt acactgtcta cagataaaaa caagtatggc     2820



attcggctaa gggcagaacc agatcacatg gtcctgggga agcgtctgaa gggagccttt     2880



aaggcagtga tgacgtccat caagcagttg agcagtgagg agctggagca gttccagaag     2940



actgggacca ttgttgtgga aggccatgaa ttgcacgatg aagacatccg cctcatgtac     3000



acctttgatc aggccacagg tgggactgcg caatttgaag cacactcaga tgctcaggct     3060



ttggtcctct tagatgtcac tcctgaccag tcaatggtag atgaaggaat ggctcgggaa     3120



gtcatcaatc gcatacagaa acttcgcaaa aagtgcaatc tggttccaac tgatgaaatc     3180



acagtgtact ataaagcaaa gtctgaagga acatatctga atagtgttat tgaaagccac     3240



acagagttca tatttaccac cataaaggct cccttgaaac catatccagt ttctccatcg     3300



gataaagtcc ttattcaaga aaaaacacag ttgaagggat ctgaactgga aattacactc     3360



accagaggat cttcccttcc tggtcctgct tgtgcatatg tcaatcttaa catttgtgca     3420



aatggcagtg aacaaggtgg agtattgctc ctggaaaatc caaaaggtga caataggttg     3480



gaccttttaa agctgaagag tgttgtcact agcatttttg gtgtgaaaaa tacagagctg     3540



gctgtcttcc atgatgaaac agaaatacaa aaccaaactg acttactgag tcttagtgga     3600



aaaacacttt gtgtgactgc aggatcggct ccctctctga tcaacagttc tagtactctt     3660



ctttgtcagt atatcaacct acagctcctg aatgcaaagc cacaagagtg tttaatgggg     3720



acagtgggca ctctcctgct tgaaaaccca cttgggcaga atggactcac ccaccaaggt     3780



cttctgtatg aagcagccaa ggtgtttggc cttcggagca ggaagctaaa gctgtttctg     3840



aatgagaccc aaacgcagga aattacagaa gacatccccg tgaagacttt gaatatgaag     3900



actgtgtatg tttctgtgtt accaacaaca gcagacttct agcatgtact tatcaatgtt     3960



gttcggtcag cccttcccta attacaccta tcccctacac atacatgcac atagacacac     4020



acatgaacac actgaagata tttccttcag gtgtgtgtaa aatatgctgc ttggattgaa     4080



attcaaatgg gattgattag tcaagtaact tgagacctca cagtaatctt cacacttaac     4140



cttagacacc tatgcagtca tgttgggagc aggttacaat gttacttcag cccacagttt     4200



atttctatac ttgagttctt aagtacagaa gatagaagtg atttaaatgg catagtatat     4260



atatcatttt ctggcctttt aaaatttatt tgagacctct tgatgaaatg gacatattat     4320



atatttctgc cacctggatt ttcctggata atttgatgga atattttaag tttcagtaaa     4380



tcagaacaat aaacaaactc agatat                                          4406





<210>  2

<211>  1262

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Leu Gln Gln Val Pro Glu Asn Ile Asn Phe Pro Ala Glu Glu Glu 

1               5                   10                  15      





Lys Ile Leu Glu Phe Trp Thr Glu Phe Asn Cys Phe Gln Glu Cys Leu 

            20                  25                  30          





Lys Gln Ser Lys His Lys Pro Lys Phe Thr Phe Tyr Asp Gly Pro Pro 

        35                  40                  45              





Phe Ala Thr Gly Leu Pro His Tyr Gly His Ile Leu Ala Gly Thr Ile 

    50                  55                  60                  





Lys Asp Ile Val Thr Arg Tyr Ala His Gln Ser Gly Phe His Val Asp 

65                  70                  75                  80  





Arg Arg Phe Gly Trp Asp Cys His Gly Leu Pro Val Glu Tyr Glu Ile 

                85                  90                  95      





Asp Lys Thr Leu Gly Ile Arg Gly Pro Glu Asp Val Ala Lys Met Gly 

            100                 105                 110         





Ile Thr Glu Tyr Asn Asn Gln Cys Arg Ala Ile Val Met Arg Tyr Ser 

        115                 120                 125             





Ala Glu Trp Lys Ser Thr Val Ser Arg Leu Gly Arg Trp Ile Asp Phe 

    130                 135                 140                 





Asp Asn Asp Tyr Lys Thr Leu Tyr Pro Gln Phe Met Glu Ser Val Trp 

145                 150                 155                 160 





Trp Val Phe Lys Gln Leu Tyr Asp Lys Gly Leu Val Tyr Arg Gly Val 

                165                 170                 175     





Lys Val Met Pro Phe Ser Thr Ala Cys Asn Thr Pro Leu Ser Asn Phe 

            180                 185                 190         





Glu Ser His Gln Asn Tyr Lys Asp Val Gln Asp Pro Ser Val Phe Val 

        195                 200                 205             





Thr Phe Pro Leu Glu Glu Asp Glu Thr Val Ser Leu Val Ala Trp Thr 

    210                 215                 220                 





Thr Thr Pro Trp Thr Leu Pro Ser Asn Leu Ala Val Cys Val Asn Pro 

225                 230                 235                 240 





Glu Met Gln Tyr Val Lys Ile Lys Asp Val Ala Arg Gly Arg Leu Leu 

                245                 250                 255     





Ile Leu Met Glu Ala Arg Leu Ser Ala Leu Tyr Lys Leu Glu Ser Asp 

            260                 265                 270         





Tyr Glu Ile Leu Glu Arg Phe Pro Gly Ala Tyr Leu Lys Gly Lys Lys 

        275                 280                 285             





Tyr Arg Pro Leu Phe Asp Tyr Phe Leu Lys Cys Lys Glu Asn Gly Ala 

    290                 295                 300                 





Phe Thr Val Leu Val Asp Asn Tyr Val Lys Glu Glu Glu Gly Thr Gly 

305                 310                 315                 320 





Val Val His Gln Ala Pro Tyr Phe Gly Ala Glu Asp Tyr Arg Val Cys 

                325                 330                 335     





Met Asp Phe Asn Ile Ile Arg Lys Asp Ser Leu Pro Val Cys Pro Val 

            340                 345                 350         





Asp Ala Ser Gly Cys Phe Thr Thr Glu Val Thr Asp Phe Ala Gly Gln 

        355                 360                 365             





Tyr Val Lys Asp Ala Asp Lys Ser Ile Ile Arg Thr Leu Lys Glu Gln 

    370                 375                 380                 





Gly Arg Leu Leu Val Ala Thr Thr Phe Thr His Ser Tyr Pro Phe Cys 

385                 390                 395                 400 





Trp Arg Ser Asp Thr Pro Leu Ile Tyr Lys Ala Val Pro Ser Trp Phe 

                405                 410                 415     





Val Arg Val Glu Asn Met Val Asp Gln Leu Leu Arg Asn Asn Asp Leu 

            420                 425                 430         





Cys Tyr Trp Val Pro Glu Leu Val Arg Glu Lys Arg Phe Gly Asn Trp 

        435                 440                 445             





Leu Lys Asp Ala Arg Asp Trp Thr Ile Ser Arg Asn Arg Tyr Trp Gly 

    450                 455                 460                 





Thr Pro Ile Pro Leu Trp Val Ser Asp Asp Phe Glu Glu Val Val Cys 

465                 470                 475                 480 





Ile Gly Ser Val Ala Glu Leu Glu Glu Leu Ser Gly Ala Lys Ile Ser 

                485                 490                 495     





Asp Leu His Arg Glu Ser Val Asp His Leu Thr Ile Pro Ser Arg Cys 

            500                 505                 510         





Gly Lys Gly Ser Leu His Arg Ile Ser Glu Val Phe Asp Cys Trp Phe 

        515                 520                 525             





Glu Ser Gly Ser Met Pro Tyr Ala Gln Val His Tyr Pro Phe Glu Asn 

    530                 535                 540                 





Lys Arg Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe Ile Ala Glu Gly 

545                 550                 555                 560 





Ile Asp Gln Thr Arg Gly Trp Phe Tyr Thr Leu Leu Val Leu Ala Thr 

                565                 570                 575     





Ala Leu Phe Gly Gln Pro Pro Phe Lys Asn Val Ile Val Asn Gly Leu 

            580                 585                 590         





Val Leu Ala Ser Asp Gly Gln Lys Met Ser Lys Arg Lys Lys Asn Tyr 

        595                 600                 605             





Pro Asp Pro Val Ser Ile Ile Gln Lys Tyr Gly Ala Asp Ala Leu Arg 

    610                 615                 620                 





Leu Tyr Leu Ile Asn Ser Pro Val Val Arg Ala Glu Asn Leu Arg Phe 

625                 630                 635                 640 





Lys Glu Glu Gly Val Arg Asp Val Leu Lys Asp Val Leu Leu Pro Trp 

                645                 650                 655     





Tyr Asn Ala Tyr Arg Phe Leu Ile Gln Asn Val Leu Arg Leu Gln Lys 

            660                 665                 670         





Glu Glu Glu Ile Glu Phe Leu Tyr Asn Glu Asn Thr Val Arg Glu Ser 

        675                 680                 685             





Pro Asn Ile Thr Asp Arg Trp Ile Leu Ser Phe Met Gln Ser Leu Ile 

    690                 695                 700                 





Gly Phe Phe Glu Thr Glu Met Ala Ala Tyr Arg Leu Tyr Thr Val Val 

705                 710                 715                 720 





Pro Arg Leu Val Lys Phe Val Asp Ile Leu Thr Asn Trp Tyr Val Arg 

                725                 730                 735     





Met Asn Arg Arg Arg Leu Lys Gly Glu Asn Gly Met Glu Asp Cys Val 

            740                 745                 750         





Met Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu 

        755                 760                 765             





Met Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu 

    770                 775                 780                 





Lys Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser 

785                 790                 795                 800 





Ile His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys 

                805                 810                 815     





Lys Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly 

            820                 825                 830         





Arg Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys 

        835                 840                 845             





Glu Ile Val Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys 

    850                 855                 860                 





Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr 

865                 870                 875                 880 





Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro 

                885                 890                 895     





Asp His Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val 

            900                 905                 910         





Met Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln 

        915                 920                 925             





Lys Thr Gly Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp 

    930                 935                 940                 





Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln 

945                 950                 955                 960 





Phe Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr 

                965                 970                 975     





Pro Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn 

            980                 985                 990         





Arg Ile Gln Lys Leu Arg Lys Lys  Cys Asn Leu Val Pro  Thr Asp Glu 

        995                 1000                 1005             





Ile Thr  Val Tyr Tyr Lys Ala  Lys Ser Glu Gly Thr  Tyr Leu Asn 

    1010                 1015                 1020             





Ser Val  Ile Glu Ser His Thr  Glu Phe Ile Phe Thr  Thr Ile Lys 

    1025                 1030                 1035             





Ala Pro  Leu Lys Pro Tyr Pro  Val Ser Pro Ser Asp  Lys Val Leu 

    1040                 1045                 1050             





Ile Gln  Glu Lys Thr Gln Leu  Lys Gly Ser Glu Leu  Glu Ile Thr 

    1055                 1060                 1065             





Leu Thr  Arg Gly Ser Ser Leu  Pro Gly Pro Ala Cys  Ala Tyr Val 

    1070                 1075                 1080             





Asn Leu  Asn Ile Cys Ala Asn  Gly Ser Glu Gln Gly  Gly Val Leu 

    1085                 1090                 1095             





Leu Leu  Glu Asn Pro Lys Gly  Asp Asn Arg Leu Asp  Leu Leu Lys 

    1100                 1105                 1110             





Leu Lys  Ser Val Val Thr Ser  Ile Phe Gly Val Lys  Asn Thr Glu 

    1115                 1120                 1125             





Leu Ala  Val Phe His Asp Glu  Thr Glu Ile Gln Asn  Gln Thr Asp 

    1130                 1135                 1140             





Leu Leu  Ser Leu Ser Gly Lys  Thr Leu Cys Val Thr  Ala Gly Ser 

    1145                 1150                 1155             





Ala Pro  Ser Leu Ile Asn Ser  Ser Ser Thr Leu Leu  Cys Gln Tyr 

    1160                 1165                 1170             





Ile Asn  Leu Gln Leu Leu Asn  Ala Lys Pro Gln Glu  Cys Leu Met 

    1175                 1180                 1185             





Gly Thr  Val Gly Thr Leu Leu  Leu Glu Asn Pro Leu  Gly Gln Asn 

    1190                 1195                 1200             





Gly Leu  Thr His Gln Gly Leu  Leu Tyr Glu Ala Ala  Lys Val Phe 

    1205                 1210                 1215             





Gly Leu  Arg Ser Arg Lys Leu  Lys Leu Phe Leu Asn  Glu Thr Gln 

    1220                 1225                 1230             





Thr Gln  Glu Ile Thr Glu Asp  Ile Pro Val Lys Thr  Leu Asn Met 

    1235                 1240                 1245             





Lys Thr  Val Tyr Val Ser Val  Leu Pro Thr Thr Ala  Asp Phe 

    1250                 1255                 1260         





<210>  3

<211>  4510

<212>  DNA

<213>  Homo sapiens



<400>  3

cggttgcagc gtggacgccg gatgagttgc ttttaggctt gctggcccgc ggggctgtcc       60



aggcacgcga ggcccctcag gtacgccctc tcttccctgc aggatccggc cctcaaagac      120



gagggtcacg cacgcgttac aaccccgaaa cagtagcaca agatttaatt tttaaaagag      180



cgtgtttctt cggggcttgc cgttcgttcg tttccagcct caggaattta tggtcgcctt      240



tttgaatgag caacaaaatg cttcaacaag ttccagaaaa cataaatttt cctgctgaag      300



aagagaaaat cttggagttt tggactgaat ttaattgttt tcaggaatgc ttaaagcaat      360



caaaacataa accaaaattt accttctatg atggtcctcc ttttgcaact ggactgcctc      420



actatggaca tatacttgcg ggtacaatta aagatatagt tacaagatat gctcaccaga      480



gtgggtttca tgttgacaga agatttggat gggattgcca tggcttacct gtggaatatg      540



aaattgataa gacactggga atcagaggac cagaggatgt ggccaaaatg gggattacag      600



agtataacaa tcagtgccga gcaattgtga tgagatattc tgctgagtgg aagtctactg      660



ttagcagact tggccgatgg attgactttg acaatgacta taaaactctg tatccacaat      720



tcatggaatc agtctggtgg gtcttcaaac aactctatga taaaggcctt gtttatagag      780



gtgtgaaagt catgcccttc tctacggcat gtaacactcc actttccaac ttcgagtcac      840



accagaatta taaggatgtt caagatcctt cagtatttgt aactttccct ttggaagaag      900



atgaaactgt atctttagtt gcttggacaa ccactccctg gactctacct agtaaccttg      960



ctgtgtgtgt taatccagaa atgcaatatg tgaaaattaa agatgttgcc agaggacgat     1020



tactcatttt aatggaagcc agattgtcag ccctctataa attggagagt gactatgaga     1080



tccttgaaag atttcctggt gcctatctta aaggcaagaa gtacaggccc ctgtttgact     1140



atttcctgaa gtgtaaagag aatggcgctt tcactgtgct tgttgacaac tatgtgaagg     1200



aagaagaagg cacaggggtt gtccaccaag ctccttactt cggtgctgag gactatcggg     1260



tctgtatgga ctttaacatt attcggaaag actcactccc tgtttgccct gtggatgctt     1320



caggctgctt cacaacggag gtgacagatt tcgcaggaca gtatgtgaag gatgctgaca     1380



aaagtatcat caggactttg aaggaacaag gccgacttct ggttgccacc accttcactc     1440



acagctaccc tttttgctgg agatcagaca ctcctctaat ttacaaagca gtgcccagct     1500



ggtttgtgcg agtggagaac atggtggacc agctcctaag gaacaatgac ctgtgctact     1560



gggtcccaga gttggtacga gaaaaacgat ttggaaattg gctgaaagat gcacgtgact     1620



ggacaatttc cagaaacaga tactggggca cccccatccc actgtgggtc agcgatgact     1680



ttgaggaggt ggtatgcatt gggtcagtgg cggaacttga agaactgtca ggagcaaaga     1740



tctcagatct ccacagagag agtgttgacc acctgaccat tccttcacgc tgtgggaagg     1800



gatccttgca ccgcatctct gaagtgtttg actgttggtt tgagagtggc agcatgccct     1860



atgctcaggt tcattacccg tttgaaaaca agagggagtt tgaggatgct tttcctgcag     1920



atttcattgc cgagggcatc gaccaaacca gaggatggtt ttataccctg ctggtgctgg     1980



ccacggccct ctttggacaa ccgcctttca agaacgtaat tgtgaatggg cttgtcctgg     2040



caagtgatgg ccaaaaaatg agcaaacgga aaaagaatta tccagatcca gtttccatca     2100



tccagaagta tggtgctgat gccctcagat tatatctgat taactcccct gtggtgagag     2160



cagaaaacct ccgctttaaa gaagagggtg tgcgggacgt ccttaaggat gtactgctcc     2220



catggtacaa tgcctatcgc ttcttaatcc agaacgttct gaggctccag aaggaggaag     2280



aaatagaatt tctctacaat gagaacacgg ttagagaaag ccccaacatt acagaccggt     2340



ggatcctgtc cttcatgcag tctctcattg gcttctttga gactgaaatg gcagcttata     2400



ggctttatac tgtggtgcct cgcctggtca agtttgtaga tattctgacc aattggtatg     2460



ttagaatgaa ccgcagaaga ttaaagggtg aaaatgggat ggaggattgt gtcatggccc     2520



tagaaacctt gtttagtgtt ctgctttctc tttgcagact tatggctccc tacacacctt     2580



ttctcactga attgatgtac cagaatctaa aggtgctgat tgaccctgtt tctgttcagg     2640



acaaggacac actcagcatt cactacctca tgctgccccg tgttcgagaa gaattgattg     2700



acaagaaaac agagagtgca gtatctcaga tgcagtctgt gattgaactt ggaagagtga     2760



tcagagaccg aaaaactatt cccataaagt atcctttgaa agaaattgtg gttatccatc     2820



aagatccaga agctcttaaa gatatcaagt ctttggagaa gtatatcatt gaggaactca     2880



atgttcgaaa agttacactg tctacagata aaaacaagta tggcattcgg ctaagggcag     2940



aaccagatca catggtcctg gggaagcgtc tgaagggagc ctttaaggca gtgatgacgt     3000



ccatcaagca gttgagcagt gaggagctgg agcagttcca gaagactggg accattgttg     3060



tggaaggcca tgaattgcac gatgaagaca tccgcctcat gtacaccttt gatcaggcca     3120



caggtgggac tgcgcaattt gaagcacact cagatgctca ggctttggtc ctcttagatg     3180



tcactcctga ccagtcaatg gtagatgaag gaatggctcg ggaagtcatc aatcgcatac     3240



agaaacttcg caaaaagtgc aatctggttc caactgatga aatcacagtg tactataaag     3300



caaagtctga aggaacatat ctgaatagtg ttattgaaag ccacacagag ttcatattta     3360



ccaccataaa ggctcccttg aaaccatatc cagtttctcc atcggataaa gtccttattc     3420



aagaaaaaac acagttgaag ggatctgaac tggaaattac actcaccaga ggatcttccc     3480



ttcctggtcc tgcttgtgca tatgtcaatc ttaacatttg tgcaaatggc agtgaacaag     3540



gtggagtatt gctcctggaa aatccaaaag gtgacaatag gttggacctt ttaaagctga     3600



agagtgttgt cactagcatt tttggtgtga aaaatacaga gctggctgtc ttccatgatg     3660



aaacagaaat acaaaaccaa actgacttac tgagtcttag tggaaaaaca ctttgtgtga     3720



ctgcaggatc ggctccctct ctgatcaaca gttctagtac tcttctttgt cagtatatca     3780



acctacagct cctgaatgca aagccacaag agtgtttaat ggggacagtg ggcactctcc     3840



tgcttgaaaa cccacttggg cagaatggac tcacccacca aggtcttctg tatgaagcag     3900



ccaaggtgtt tggccttcgg agcaggaagc taaagctgtt tctgaatgag acccaaacgc     3960



aggaaattac agaagacatc cccgtgaaga ctttgaatat gaagactgtg tatgtttctg     4020



tgttaccaac aacagcagac ttctagcatg tacttatcaa tgttgttcgg tcagcccttc     4080



cctaattaca cctatcccct acacatacat gcacatagac acacacatga acacactgaa     4140



gatatttcct tcaggtgtgt gtaaaatatg ctgcttggat tgaaattcaa atgggattga     4200



ttagtcaagt aacttgagac ctcacagtaa tcttcacact taaccttaga cacctatgca     4260



gtcatgttgg gagcaggtta caatgttact tcagcccaca gtttatttct atacttgagt     4320



tcttaagtac agaagataga agtgatttaa atggcatagt atatatatca ttttctggcc     4380



ttttaaaatt tatttgagac ctcttgatga aatggacata ttatatattt ctgccacctg     4440



gattttcctg gataatttga tggaatattt taagtttcag taaatcagaa caataaacaa     4500



actcagatat                                                            4510





<210>  4

<211>  1262

<212>  PRT

<213>  Homo sapiens



<400>  4



Met Leu Gln Gln Val Pro Glu Asn Ile Asn Phe Pro Ala Glu Glu Glu 

1               5                   10                  15      





Lys Ile Leu Glu Phe Trp Thr Glu Phe Asn Cys Phe Gln Glu Cys Leu 

            20                  25                  30          





Lys Gln Ser Lys His Lys Pro Lys Phe Thr Phe Tyr Asp Gly Pro Pro 

        35                  40                  45              





Phe Ala Thr Gly Leu Pro His Tyr Gly His Ile Leu Ala Gly Thr Ile 

    50                  55                  60                  





Lys Asp Ile Val Thr Arg Tyr Ala His Gln Ser Gly Phe His Val Asp 

65                  70                  75                  80  





Arg Arg Phe Gly Trp Asp Cys His Gly Leu Pro Val Glu Tyr Glu Ile 

                85                  90                  95      





Asp Lys Thr Leu Gly Ile Arg Gly Pro Glu Asp Val Ala Lys Met Gly 

            100                 105                 110         





Ile Thr Glu Tyr Asn Asn Gln Cys Arg Ala Ile Val Met Arg Tyr Ser 

        115                 120                 125             





Ala Glu Trp Lys Ser Thr Val Ser Arg Leu Gly Arg Trp Ile Asp Phe 

    130                 135                 140                 





Asp Asn Asp Tyr Lys Thr Leu Tyr Pro Gln Phe Met Glu Ser Val Trp 

145                 150                 155                 160 





Trp Val Phe Lys Gln Leu Tyr Asp Lys Gly Leu Val Tyr Arg Gly Val 

                165                 170                 175     





Lys Val Met Pro Phe Ser Thr Ala Cys Asn Thr Pro Leu Ser Asn Phe 

            180                 185                 190         





Glu Ser His Gln Asn Tyr Lys Asp Val Gln Asp Pro Ser Val Phe Val 

        195                 200                 205             





Thr Phe Pro Leu Glu Glu Asp Glu Thr Val Ser Leu Val Ala Trp Thr 

    210                 215                 220                 





Thr Thr Pro Trp Thr Leu Pro Ser Asn Leu Ala Val Cys Val Asn Pro 

225                 230                 235                 240 





Glu Met Gln Tyr Val Lys Ile Lys Asp Val Ala Arg Gly Arg Leu Leu 

                245                 250                 255     





Ile Leu Met Glu Ala Arg Leu Ser Ala Leu Tyr Lys Leu Glu Ser Asp 

            260                 265                 270         





Tyr Glu Ile Leu Glu Arg Phe Pro Gly Ala Tyr Leu Lys Gly Lys Lys 

        275                 280                 285             





Tyr Arg Pro Leu Phe Asp Tyr Phe Leu Lys Cys Lys Glu Asn Gly Ala 

    290                 295                 300                 





Phe Thr Val Leu Val Asp Asn Tyr Val Lys Glu Glu Glu Gly Thr Gly 

305                 310                 315                 320 





Val Val His Gln Ala Pro Tyr Phe Gly Ala Glu Asp Tyr Arg Val Cys 

                325                 330                 335     





Met Asp Phe Asn Ile Ile Arg Lys Asp Ser Leu Pro Val Cys Pro Val 

            340                 345                 350         





Asp Ala Ser Gly Cys Phe Thr Thr Glu Val Thr Asp Phe Ala Gly Gln 

        355                 360                 365             





Tyr Val Lys Asp Ala Asp Lys Ser Ile Ile Arg Thr Leu Lys Glu Gln 

    370                 375                 380                 





Gly Arg Leu Leu Val Ala Thr Thr Phe Thr His Ser Tyr Pro Phe Cys 

385                 390                 395                 400 





Trp Arg Ser Asp Thr Pro Leu Ile Tyr Lys Ala Val Pro Ser Trp Phe 

                405                 410                 415     





Val Arg Val Glu Asn Met Val Asp Gln Leu Leu Arg Asn Asn Asp Leu 

            420                 425                 430         





Cys Tyr Trp Val Pro Glu Leu Val Arg Glu Lys Arg Phe Gly Asn Trp 

        435                 440                 445             





Leu Lys Asp Ala Arg Asp Trp Thr Ile Ser Arg Asn Arg Tyr Trp Gly 

    450                 455                 460                 





Thr Pro Ile Pro Leu Trp Val Ser Asp Asp Phe Glu Glu Val Val Cys 

465                 470                 475                 480 





Ile Gly Ser Val Ala Glu Leu Glu Glu Leu Ser Gly Ala Lys Ile Ser 

                485                 490                 495     





Asp Leu His Arg Glu Ser Val Asp His Leu Thr Ile Pro Ser Arg Cys 

            500                 505                 510         





Gly Lys Gly Ser Leu His Arg Ile Ser Glu Val Phe Asp Cys Trp Phe 

        515                 520                 525             





Glu Ser Gly Ser Met Pro Tyr Ala Gln Val His Tyr Pro Phe Glu Asn 

    530                 535                 540                 





Lys Arg Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe Ile Ala Glu Gly 

545                 550                 555                 560 





Ile Asp Gln Thr Arg Gly Trp Phe Tyr Thr Leu Leu Val Leu Ala Thr 

                565                 570                 575     





Ala Leu Phe Gly Gln Pro Pro Phe Lys Asn Val Ile Val Asn Gly Leu 

            580                 585                 590         





Val Leu Ala Ser Asp Gly Gln Lys Met Ser Lys Arg Lys Lys Asn Tyr 

        595                 600                 605             





Pro Asp Pro Val Ser Ile Ile Gln Lys Tyr Gly Ala Asp Ala Leu Arg 

    610                 615                 620                 





Leu Tyr Leu Ile Asn Ser Pro Val Val Arg Ala Glu Asn Leu Arg Phe 

625                 630                 635                 640 





Lys Glu Glu Gly Val Arg Asp Val Leu Lys Asp Val Leu Leu Pro Trp 

                645                 650                 655     





Tyr Asn Ala Tyr Arg Phe Leu Ile Gln Asn Val Leu Arg Leu Gln Lys 

            660                 665                 670         





Glu Glu Glu Ile Glu Phe Leu Tyr Asn Glu Asn Thr Val Arg Glu Ser 

        675                 680                 685             





Pro Asn Ile Thr Asp Arg Trp Ile Leu Ser Phe Met Gln Ser Leu Ile 

    690                 695                 700                 





Gly Phe Phe Glu Thr Glu Met Ala Ala Tyr Arg Leu Tyr Thr Val Val 

705                 710                 715                 720 





Pro Arg Leu Val Lys Phe Val Asp Ile Leu Thr Asn Trp Tyr Val Arg 

                725                 730                 735     





Met Asn Arg Arg Arg Leu Lys Gly Glu Asn Gly Met Glu Asp Cys Val 

            740                 745                 750         





Met Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu 

        755                 760                 765             





Met Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu 

    770                 775                 780                 





Lys Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser 

785                 790                 795                 800 





Ile His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys 

                805                 810                 815     





Lys Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly 

            820                 825                 830         





Arg Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys 

        835                 840                 845             





Glu Ile Val Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys 

    850                 855                 860                 





Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr 

865                 870                 875                 880 





Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro 

                885                 890                 895     





Asp His Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val 

            900                 905                 910         





Met Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln 

        915                 920                 925             





Lys Thr Gly Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp 

    930                 935                 940                 





Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln 

945                 950                 955                 960 





Phe Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr 

                965                 970                 975     





Pro Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn 

            980                 985                 990         





Arg Ile Gln Lys Leu Arg Lys Lys  Cys Asn Leu Val Pro  Thr Asp Glu 

        995                 1000                 1005             





Ile Thr  Val Tyr Tyr Lys Ala  Lys Ser Glu Gly Thr  Tyr Leu Asn 

    1010                 1015                 1020             





Ser Val  Ile Glu Ser His Thr  Glu Phe Ile Phe Thr  Thr Ile Lys 

    1025                 1030                 1035             





Ala Pro  Leu Lys Pro Tyr Pro  Val Ser Pro Ser Asp  Lys Val Leu 

    1040                 1045                 1050             





Ile Gln  Glu Lys Thr Gln Leu  Lys Gly Ser Glu Leu  Glu Ile Thr 

    1055                 1060                 1065             





Leu Thr  Arg Gly Ser Ser Leu  Pro Gly Pro Ala Cys  Ala Tyr Val 

    1070                 1075                 1080             





Asn Leu  Asn Ile Cys Ala Asn  Gly Ser Glu Gln Gly  Gly Val Leu 

    1085                 1090                 1095             





Leu Leu  Glu Asn Pro Lys Gly  Asp Asn Arg Leu Asp  Leu Leu Lys 

    1100                 1105                 1110             





Leu Lys  Ser Val Val Thr Ser  Ile Phe Gly Val Lys  Asn Thr Glu 

    1115                 1120                 1125             





Leu Ala  Val Phe His Asp Glu  Thr Glu Ile Gln Asn  Gln Thr Asp 

    1130                 1135                 1140             





Leu Leu  Ser Leu Ser Gly Lys  Thr Leu Cys Val Thr  Ala Gly Ser 

    1145                 1150                 1155             





Ala Pro  Ser Leu Ile Asn Ser  Ser Ser Thr Leu Leu  Cys Gln Tyr 

    1160                 1165                 1170             





Ile Asn  Leu Gln Leu Leu Asn  Ala Lys Pro Gln Glu  Cys Leu Met 

    1175                 1180                 1185             





Gly Thr  Val Gly Thr Leu Leu  Leu Glu Asn Pro Leu  Gly Gln Asn 

    1190                 1195                 1200             





Gly Leu  Thr His Gln Gly Leu  Leu Tyr Glu Ala Ala  Lys Val Phe 

    1205                 1210                 1215             





Gly Leu  Arg Ser Arg Lys Leu  Lys Leu Phe Leu Asn  Glu Thr Gln 

    1220                 1225                 1230             





Thr Gln  Glu Ile Thr Glu Asp  Ile Pro Val Lys Thr  Leu Asn Met 

    1235                 1240                 1245             





Lys Thr  Val Tyr Val Ser Val  Leu Pro Thr Thr Ala  Asp Phe 

    1250                 1255                 1260         





<210>  5

<211>  5263

<212>  DNA

<213>  Homo sapiens



<400>  5

cggggggggc cgcgccgtgc tagccgttgg gcctgcctcg gaggaggcgt cgccgccgcc       60



gctgccgctg ccggcgccgt tgccgctgcc gggaaacaca aggaaaggga accagcgcag      120



cgtggcgatg ggcgggggta gagccccgcc ggagaggctg ggcggctgcc ggtgacagac      180



tgtgccctgt ccacggtgcc tcctgcatgt cctgctgccc tgagctgtcc cgagctaggt      240



gacagcgtac cacgctgcca ccatgaatga ggtgtctgtc atcaaagaag gctggctcca      300



caagcgtggt gaatacatca agacctggag gccacggtac ttcctgctga agagcgacgg      360



ctccttcatt gggtacaagg agaggcccga ggcccctgat cagactctac cccccttaaa      420



caacttctcc gtagcagaat gccagctgat gaagaccgag aggccgcgac ccaacacctt      480



tgtcatacgc tgcctgcagt ggaccacagt catcgagagg accttccacg tggattctcc      540



agacgagagg gaggagtgga tgcgggccat ccagatggtc gccaacagcc tcaagcagcg      600



ggccccaggc gaggacccca tggactacaa gtgtggctcc cccagtgact cctccacgac      660



tgaggagatg gaagtggcgg tcagcaaggc acgggctaaa gtgaccatga atgacttcga      720



ctatctcaaa ctccttggca agggaacctt tggcaaagtc atcctggtgc gggagaaggc      780



cactggccgc tactacgcca tgaagatcct gcggaaggaa gtcatcattg ccaaggatga      840



agtcgctcac acagtcaccg agagccgggt cctccagaac accaggcacc cgttcctcac      900



tgcgctgaag tatgccttcc agacccacga ccgcctgtgc tttgtgatgg agtatgccaa      960



cgggggtgag ctgttcttcc acctgtcccg ggagcgtgtc ttcacagagg agcgggcccg     1020



gttttatggt gcagagattg tctcggctct tgagtacttg cactcgcggg acgtggtata     1080



ccgcgacatc aagctggaaa acctcatgct ggacaaagat ggccacatca agatcactga     1140



ctttggcctc tgcaaagagg gcatcagtga cggggccacc atgaaaacct tctgtgggac     1200



cccggagtac ctggcgcctg aggtgctgga ggacaatgac tatggccggg ccgtggactg     1260



gtgggggctg ggtgtggtca tgtacgagat gatgtgcggc cgcctgccct tctacaacca     1320



ggaccacgag cgcctcttcg agctcatcct catggaagag atccgcttcc cgcgcacgct     1380



cagccccgag gccaagtccc tgcttgctgg gctgcttaag aaggacccca agcagaggct     1440



tggtgggggg cccagcgatg ccaaggaggt catggagcac aggttcttcc tcagcatcaa     1500



ctggcaggac gtggtccaga agaagctcct gccacccttc aaacctcagg tcacgtccga     1560



ggtcgacaca aggtacttcg atgatgaatt taccgcccag tccatcacaa tcacaccccc     1620



tgaccgctat gacagcctgg gcttactgga gctggaccag cggacccact tcccccagtt     1680



ctcctactcg gccagcatcc gcgagtgagc agtctgccca cgcagaggac gcacgctcgc     1740



tgccatcacc gctgggtggt tttttccccc taacttttta cttagccttt ttggtttgtg     1800



tccccacccc cacctcctca ccccctttcc agttcttctt caggcccctc ccagacgcac     1860



cccagcggcc cctgcagccc ctgcctccag cctccagcct cacctttgtg cccagactcg     1920



catttggaag actccacctc ccgcccaggc ctgggctgtt gggcggttgg agattcaggt     1980



tttaatccac acaagcccca gtgaggggtg aagcatggcg cctggggcct gcctgagttt     2040



ctggcctggg tgtcgtgctg gtgtctgcct ccgcgctgct gcatctggac gaaggctgcc     2100



ttctggtggg acgcgacacc cggcagacag tggtgctgcc ttccaggccc cgtggcctag     2160



gctcggagtg gccaggcacg gggcggtcca atcccccacc cgctgtcccc ctatgggggc     2220



agaaaagcaa taatgtccag gggcaggcag gggcccttgg gagctgcagg gctgggggtt     2280



agggctgctc cctggtgaat ggagtcagat cctaggatct gtaccatggg gaaccaggag     2340



tggccgggct gggtgccgcc tcctggtccg gcctcctccc caccaaactg tcctcaccct     2400



atggatgagg caggaggaac atttggggcc aaacctgcct gcctcccagc cccgtgcctt     2460



actagggctt ccttccagct ggccttacct cccgctggac cctgggcctg gcctggcccc     2520



actgggggct atgggctggg ctcaccctct cctctgcggg ggtggagggc caccagcctt     2580



ggctgttaca atcttacacc ggacagtatt gggccccatg gacttggtca gggaggggtg     2640



ggggtgggca tctctggtac ctattggggt ggggggcctc tgaaaaggga ggctcctagg     2700



cccccctcac ccctccctct ccccagggcc ccacgttctg cagccttaag gttgaacatg     2760



agtgcacgtc catgtcagtg ctgtgggact cctgtgcgtg cctcggactg cgtgtgtcgg     2820



cgggacgcag gcacacgtgg gtgtgtgtgc atgtgtgttt gtgtgagggc agcgtgtcct     2880



ccagtgtgca tggtgtgtgg gcttgggccc catccctggc ccgagcattt catcctgtgg     2940



gggaggggtg ctgacctagt gggaggagcc ccactgtgat ccatgagctg ccctgcccac     3000



gcctcccctc cctgtagcaa cacctctggg tgtttggagt ttagcttttg tgggtttgct     3060



ctccctatcc catctcctgt actacacagt tcatggcagg gtggggaggg gtggggttgg     3120



ttcgggtggg tgagggtctt tttcctctgt gtgcgatgtt gttatctgac agttctccgt     3180



ccctactggc ctttctcctc gtcttcatat ttgtacggta caagcaataa agacactcat     3240



ttcagaccag ggcccagcct gcactcacgc cagcccaacc actctgggct ttgccttggt     3300



gatggagtca gacccctggg ccccagctcc tcctgtacta gccgttccct tcagcaagga     3360



gggcactgag ctcagggtga gggcagctgg ggtgtgtgca ggagctcagg ctggagaggg     3420



tgggtggagc tggtgctgtg gggctgaggg gtatgggaag gctccccgca tgtgggggtg     3480



gggtggacag agaccactcc aggccctcag tgctgcttag gctaagagag gtggggtgga     3540



gggacagggc tggaagatct gggtagccca gaatgaggag ggtgcctgtg ctgtcactga     3600



atgagaggga gtggttcatt ccacccggct gccgagcctc agaggggggc attcctatcc     3660



tgccccacct ccctgtttat gctgccacct ggaagccttg aggcccccaa attccagtac     3720



agacccagtg gtgtgttcat ggtggcgtgg ttgctgtcac ctgggagctc ctgagcgttt     3780



ggttagaacc ctgttcagct tggggtcagc cctcccctag tcactgccct ttagcctgga     3840



tgtgtctggg cccctgcact tcccgtgctt gagtcacgtg gctgcatggc cgggcgctgg     3900



ccggatggaa cacctccccc agcaagggac cagggaccag agccctggcc tgccctgctg     3960



agccctgctg tgcagagggc ctggcacaga tgaatttgag attttgccgc aaggtgttag     4020



cacttcacac ccattgagtc tttgagattt taagtgaatg taagcagaaa aagtcagatc     4080



caatttacag aaatcagagt tagctacagc taggactcgt ttggttgggg ttttttagtt     4140



tgtctttcta aagtcatgtg gaccttaatt taattacaaa agtctaccct ggtggtcata     4200



aaataggcag gcctatgaag aaaggccttt tactcttcca tctcatccca gccccgagtt     4260



gacccacgtt gctgctcctc acaccatggt gatgcaggtc tcgtagtgtg ggcacaggcc     4320



tggctacctc atctttttag tgcctctctc ctcttccaca ggatggggtc ccacagctgc     4380



agcagctggc cccgtagttg agcatgtgtg gttatcctgt agagcttttc ccaagaaggg     4440



tgtttgaact tagagtctta ataaaatctt accaaataaa ttttgagtag aataatcgtc     4500



ttttgcaatg tacattttaa aaatttcaca cattcttttt tgtatataaa gaacagtgac     4560



tgggcacagt ggctcatgcc tgtaatccca gcaatttggg aggccgaggc gggcgggtct     4620



cttgaggcca ggggttcgag accagcctgg gcatcatagg gagaccttca tctctacaaa     4680



aaatacaaaa attagctggg catggtggtg catgcctgca atcccagcta acttggaagg     4740



ctgaggtgag gtgggaagat cacttgagcc caggagtttg aggctgcagt gagctatgat     4800



tgcggcactg cactgcagcc tgggacaatg agactgtgtc tctaaaaata aaaaaaaaaa     4860



aaacatgata catgctatta aaaaagacag caaagcagga gtataagaaa ggaaattcac     4920



ccgaggtcgc agggccttga gtactcattt tggtgctgat tacctctctg caaatggaca     4980



cggcatcata aattggtagt ttcctgctct ttttgtgtaa tcttttccag ttaatgtgaa     5040



gcctctgggg gctgccctcg tgcactgatg gttgtgtgga gtcgggggcg gcagtgcgat     5100



tcccttttag ctgctgcatg gggggaactc aggctttcca gctgcttcct ggggttccat     5160



ggggtagacc cctcaaccgc ttcagctgcc ccgttaacag gaattgactt ggtttcgttt     5220



ggtgctacca gcagtcctgt aataaactag ctatccatct gta                       5263





<210>  6

<211>  481

<212>  PRT

<213>  Homo sapiens



<400>  6



Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 

1               5                   10                  15      





Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 

            20                  25                  30          





Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 

        35                  40                  45              





Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 

    50                  55                  60                  





Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 

65                  70                  75                  80  





Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 

                85                  90                  95      





Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 

            100                 105                 110         





Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 

        115                 120                 125             





Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 

    130                 135                 140                 





Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 

145                 150                 155                 160 





Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 

                165                 170                 175     





Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 

            180                 185                 190         





Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 

        195                 200                 205             





His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 

    210                 215                 220                 





Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 

225                 230                 235                 240 





Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly 

                245                 250                 255     





Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 

            260                 265                 270         





Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 

        275                 280                 285             





Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 

    290                 295                 300                 





Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 

305                 310                 315                 320 





Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 

                325                 330                 335     





Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 

            340                 345                 350         





Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 

        355                 360                 365             





Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 

    370                 375                 380                 





Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 

385                 390                 395                 400 





Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 

                405                 410                 415     





Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 

            420                 425                 430         





Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 

        435                 440                 445             





Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 

    450                 455                 460                 





Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 

465                 470                 475                 480 





Glu 

    





<210>  7

<211>  8733

<212>  DNA

<213>  Homo sapiens



<400>  7

gctcccggct tagaggacag cggggaaggc gggcggtggg gcagggggcc tgaagcggcg       60



gtaccggtgc tggcggcggc agctgaggcc ttggccgaag ccgcgcgaac ctcagggcaa      120



gatgcttgga accggacctg ccgccgccac caccgctgcc accacatcta gcaatgtgag      180



cgtcctgcag cagtttgcca gtggcctaaa gagccggaat gaggaaacca gggccaaagc      240



cgccaaggag ctccagcact atgtcaccat ggaactccga gagatgagtc aagaggagtc      300



tactcgcttc tatgaccaac tgaaccatca catttttgaa ttggtttcca gctcagatgc      360



caatgagagg aaaggtggca tcttggccat agctagcctc ataggagtgg aaggtgggaa      420



tgccacccga attggcagat ttgccaacta tcttcggaac ctcctcccct ccaatgaccc      480



agttgtcatg gaaatggcat ccaaggccat tggccgtctt gccatggcag gggacacttt      540



taccgctgag tacgtggaat ttgaggtgaa gcgagccctg gaatggctgg gtgctgaccg      600



caatgagggc cggagacatg cagctgtcct ggttctccgt gagctggcca tcagcgtccc      660



taccttcttc ttccagcaag tgcaaccctt ctttgacaac atttttgtgg ccgtgtggga      720



ccccaaacag gccatccgtg agggagctgt agccgccctt cgtgcctgtc tgattctcac      780



aacccagcgt gagccgaagg agatgcagaa gcctcagtgg tacaggcaca catttgaaga      840



agcagagaag ggatttgatg agaccttggc caaagagaag ggcatgaatc gggatgatcg      900



gatccatgga gccttgttga tccttaacga gctggtccga atcagcagca tggagggaga      960



gcgtctgaga gaagaaatgg aagaaatcac acagcagcag ctggtacacg acaagtactg     1020



caaagatctc atgggcttcg gaacaaaacc tcgtcacatt acccccttca ccagtttcca     1080



ggctgtacag ccccagcagt caaatgcctt ggtggggctg ctggggtaca gctctcacca     1140



aggcctcatg ggatttggga cctcccccag tccagctaag tccaccctgg tggagagccg     1200



gtgttgcaga gacttgatgg aggagaaatt tgatcaggtg tgccagtggg tgctgaaatg     1260



caggaatagc aagaactcgc tgatccaaat gacaatcctt aatttgttgc cccgcttggc     1320



tgcattccga ccttctgcct tcacagatac ccagtatctc caagatacca tgaaccatgt     1380



cctaagctgt gtcaagaagg agaaggaacg tacagcggcc ttccaagccc tggggctact     1440



ttctgtggct gtgaggtctg agtttaaggt ctatttgcct cgcgtgctgg acatcatccg     1500



agcggccctg cccccaaagg acttcgccca taagaggcag aaggcaatgc aggtggatgc     1560



cacagtcttc acttgcatca gcatgctggc tcgagcaatg gggccaggca tccagcagga     1620



tatcaaggag ctgctggagc ccatgctggc agtgggacta agccctgccc tcactgcagt     1680



gctctacgac ctgagccgtc agattccaca gctaaagaag gacattcaag atgggctact     1740



gaaaatgctg tccctggtcc ttatgcacaa accccttcgc cacccaggca tgcccaaggg     1800



cctggcccat cagctggcct ctcctggcct cacgaccctc cctgaggcca gcgatgtggg     1860



cagcatcact cttgccctcc gaacgcttgg cagctttgaa tttgaaggcc actctctgac     1920



ccaatttgtt cgccactgtg cggatcattt cctgaacagt gagcacaagg agatccgcat     1980



ggaggctgcc cgcacctgct cccgcctgct cacaccctcc atccacctca tcagtggcca     2040



tgctcatgtg gttagccaga ccgcagtgca agtggtggca gatgtgctta gcaaactgct     2100



cgtagttggg ataacagatc ctgaccctga cattcgctac tgtgtcttgg cgtccctgga     2160



cgagcgcttt gatgcacacc tggcccaggc ggagaacttg caggccttgt ttgtggctct     2220



gaatgaccag gtgtttgaga tccgggagct ggccatctgc actgtgggcc gactcagtag     2280



catgaaccct gcctttgtca tgcctttcct gcgcaagatg ctcatccaga ttttgacaga     2340



gttggagcac agtgggattg gaagaatcaa agagcagagt gcccgcatgc tggggcacct     2400



ggtctccaat gccccccgac tcatccgccc ctacatggag cctattctga aggcattaat     2460



tttgaaactg aaagatccag accctgatcc aaacccaggt gtgatcaata atgtcctggc     2520



aacaatagga gaattggcac aggttagtgg cctggaaatg aggaaatggg ttgatgaact     2580



ttttattatc atcatggaca tgctccagga ttcctctttg ttggccaaaa ggcaggtggc     2640



tctgtggacc ctgggacagt tggtggccag cactggctat gtagtagagc cctacaggaa     2700



gtaccctact ttgcttgagg tgctactgaa ttttctgaag actgagcaga accagggtac     2760



acgcagagag gccatccgtg tgttagggct tttaggggct ttggatcctt acaagcacaa     2820



agtgaacatt ggcatgatag accagtcccg ggatgcctct gctgtcagcc tgtcagaatc     2880



caagtcaagt caggattcct ctgactatag cactagtgaa atgctggtca acatgggaaa     2940



cttgcctctg gatgagttct acccagctgt gtccatggtg gccctgatgc ggatcttccg     3000



agaccagtca ctctctcatc atcacaccat ggttgtccag gccatcacct tcatcttcaa     3060



gtccctggga ctcaaatgtg tgcagttcct gccccaggtc atgcccacgt tccttaacgt     3120



cattcgagtc tgtgatgggg ccatccggga atttttgttc cagcagctgg gaatgttggt     3180



gtcctttgtg aagagccaca tcagacctta tatggatgaa atagtcaccc tcatgagaga     3240



attctgggtc atgaacacct caattcagag cacgatcatt cttctcattg agcaaattgt     3300



ggtagctctt gggggtgaat ttaagctcta cctgccccag ctgatcccac acatgctgcg     3360



tgtcttcatg catgacaaca gcccaggccg cattgtctct atcaagttac tggctgcaat     3420



ccagctgttt ggcgccaacc tggatgacta cctgcattta ctgctgcctc ctattgttaa     3480



gttgtttgat gcccctgaag ctccactgcc atctcgaaag gcagcgctag agactgtgga     3540



ccgcctgacg gagtccctgg atttcactga ctatgcctcc cggatcattc accctattgt     3600



tcgaacactg gaccagagcc cagaactgcg ctccacagcc atggacacgc tgtcttcact     3660



tgtttttcag ctggggaaga agtaccaaat tttcattcca atggtgaata aagttctggt     3720



gcgacaccga atcaatcatc agcgctatga tgtgctcatc tgcagaattg tcaagggata     3780



cacacttgct gatgaagagg aggatccttt gatttaccag catcggatgc ttaggagtgg     3840



ccaaggggat gcattggcta gtggaccagt ggaaacagga cccatgaaga aactgcacgt     3900



cagcaccatc aacctccaaa aggcctgggg cgctgccagg agggtctcca aagatgactg     3960



gctggaatgg ctgagacggc tgagcctgga gctgctgaag gactcatcat cgccctccct     4020



gcgctcctgc tgggccctgg cacaggccta caacccgatg gccagggatc tcttcaatgc     4080



tgcatttgtg tcctgctggt ctgaactgaa tgaagatcaa caggatgagc tcatcagaag     4140



catcgagttg gccctcacct cacaagacat cgctgaagtc acacagaccc tcttaaactt     4200



ggctgaattc atggaacaca gtgacaaggg ccccctgcca ctgagagatg acaatggcat     4260



tgttctgctg ggtgagagag ctgccaagtg ccgagcatat gccaaagcac tacactacaa     4320



agaactggag ttccagaaag gccccacccc tgccattcta gaatctctca tcagcattaa     4380



taataagcta cagcagccgg aggcagcggc cggagtgtta gaatatgcca tgaaacactt     4440



tggagagctg gagatccagg ctacctggta tgagaaactg cacgagtggg aggatgccct     4500



tgtggcctat gacaagaaaa tggacaccaa caaggacgac ccagagctga tgctgggccg     4560



catgcgctgc ctcgaggcct tgggggaatg gggtcaactc caccagcagt gctgtgaaaa     4620



gtggaccctg gttaatgatg agacccaagc caagatggcc cggatggctg ctgcagctgc     4680



atggggttta ggtcagtggg acagcatgga agaatacacc tgtatgatcc ctcgggacac     4740



ccatgatggg gcattttata gagctgtgct ggcactgcat caggacctct tctccttggc     4800



acaacagtgc attgacaagg ccagggacct gctggatgct gaattaactg cgatggcagg     4860



agagagttac agtcgggcat atggggccat ggtttcttgc cacatgctgt ccgagctgga     4920



ggaggttatc cagtacaaac ttgtccccga gcgacgagag atcatccgcc agatctggtg     4980



ggagagactg cagggctgcc agcgtatcgt agaggactgg cagaaaatcc ttatggtgcg     5040



gtcccttgtg gtcagccctc atgaagacat gagaacctgg ctcaagtatg caagcctgtg     5100



cggcaagagt ggcaggctgg ctcttgctca taaaacttta gtgttgctcc tgggagttga     5160



tccgtctcgg caacttgacc atcctctgcc aacagttcac cctcaggtga cctatgccta     5220



catgaaaaac atgtggaaga gtgcccgcaa gatcgatgcc ttccagcaca tgcagcattt     5280



tgtccagacc atgcagcaac aggcccagca tgccatcgct actgaggacc agcagcataa     5340



gcaggaactg cacaagctca tggcccgatg cttcctgaaa cttggagagt ggcagctgaa     5400



tctacagggc atcaatgaga gcacaatccc caaagtgctg cagtactaca gcgccgccac     5460



agagcacgac cgcagctggt acaaggcctg gcatgcgtgg gcagtgatga acttcgaagc     5520



tgtgctacac tacaaacatc agaaccaagc ccgcgatgag aagaagaaac tgcgtcatgc     5580



cagcggggcc aacatcacca acgccaccac tgccgccacc acggccgcca ctgccaccac     5640



cactgccagc accgagggca gcaacagtga gagcgaggcc gagagcaccg agaacagccc     5700



caccccatcg ccgctgcaga agaaggtcac tgaggatctg tccaaaaccc tcctgatgta     5760



cacggtgcct gccgtccagg gcttcttccg ttccatctcc ttgtcacgag gcaacaacct     5820



ccaggataca ctcagagttc tcaccttatg gtttgattat ggtcactggc cagatgtcaa     5880



tgaggcctta gtggaggggg tgaaagccat ccagattgat acctggctac aggttatacc     5940



tcagctcatt gcaagaattg atacgcccag acccttggtg ggacgtctca ttcaccagct     6000



tctcacagac attggtcggt accaccccca ggccctcatc tacccactga cagtggcttc     6060



taagtctacc acgacagccc ggcacaatgc agccaacaag attctgaaga acatgtgtga     6120



gcacagcaac accctggtcc agcaggccat gatggtgagc gaggagctga tccgagtggc     6180



catcctctgg catgagatgt ggcatgaagg cctggaagag gcatctcgtt tgtactttgg     6240



ggaaaggaac gtgaaaggca tgtttgaggt gctggagccc ttgcatgcta tgatggaacg     6300



gggcccccag actctgaagg aaacatcctt taatcaggcc tatggtcgag atttaatgga     6360



ggcccaagag tggtgcagga agtacatgaa atcagggaat gtcaaggacc tcacccaagc     6420



ctgggacctc tattatcatg tgttccgacg aatctcaaag cagctgcctc agctcacatc     6480



cttagagctg caatatgttt ccccaaaact tctgatgtgc cgggaccttg aattggctgt     6540



gccaggaaca tatgacccca accagccaat cattcgcatt cagtccatag caccgtcttt     6600



gcaagtcatc acatccaagc agaggccccg gaaattgaca cttatgggca gcaacggaca     6660



tgagtttgtt ttccttctaa aaggccatga agatctgcgc caggatgagc gtgtgatgca     6720



gctcttcggc ctggttaaca cccttctggc caatgaccca acatctcttc ggaaaaacct     6780



cagcatccag agatacgctg tcatcccttt atcgaccaac tcgggcctca ttggctgggt     6840



tccccactgt gacacactgc acgccctcat ccgggactac agggagaaga agaagatcct     6900



tctcaacatc gagcatcgca tcatgttgcg gatggctccg gactatgacc acttgactct     6960



gatgcagaag gtggaggtgt ttgagcatgc cgtcaataat acagctgggg acgacctggc     7020



caagctgctg tggctgaaaa gccccagctc cgaggtgtgg tttgaccgaa gaaccaatta     7080



tacccgttct ttagcggtca tgtcaatggt tgggtatatt ttaggcctgg gagatagaca     7140



cccatccaac ctgatgctgg accgtctgag tgggaagatc ctgcacattg actttgggga     7200



ctgctttgag gttgctatga cccgagagaa gtttccagag aagattccat ttagactaac     7260



aagaatgttg accaatgcta tggaggttac aggcctggat ggcaactaca gaatcacatg     7320



ccacacagtg atggaggtgc tgcgagagca caaggacagt gtcatggccg tgctggaagc     7380



ctttgtctat gaccccttgc tgaactggag gctgatggac acaaatacca aaggcaacaa     7440



gcgatcccga acgaggacgg attcctactc tgctggccag tcagtcgaaa ttttggacgg     7500



tgtggaactt ggagagccag cccataagaa aacggggacc acagtgccag aatctattca     7560



ttctttcatt ggagacggtt tggtgaaacc agaggcccta aataagaaag ctatccagat     7620



tattaacagg gttcgagata agctcactgg tcgggacttc tctcatgatg acactttgga     7680



tgttccaacg caagttgagc tgctcatcaa acaagcgaca tcccatgaaa acctctgcca     7740



gtgctatatt ggctggtgcc ctttctggta actggaggcc cagatgtgcc catcacgttt     7800



tttctgaggc ttttgtactt tagtaaatgc ttccactaaa ctgaaaccat ggtgagaaag     7860



tttgactttg ttaaatattt tgaaatgtaa atgaaaagaa ctactgtata ttaaaagttg     7920



gtttgaacca actttctagc tgctgttgaa gaatatattg tcagaaacac aaggcttgat     7980



ttggttccca ggacagtgaa acatagtaat accacgtaaa tcaagccatt cattttgggg     8040



aacagaagat ccataacttt agaaatacgg gttttgactt aactcacaag agaactcatc     8100



ataagtactt gctgatggaa gaatgaccta gttgctcctc tcaacatggg tacagcaaac     8160



tcagcacagc caagaagcct caggtcgtgg agaacatgga ttaggatcct agactgtaaa     8220



gacacagaag atgctgacct cacccctgcc acctatccca agacctcact ggtctgtgga     8280



cagcagcaga aatgtttgca agataggcca aaatgagtac aaaaggtctg tcttccatca     8340



gacccagtga tgctgcgact cacacgcttc aattcaagac ctgaccgcta gtagggaggt     8400



ttattcagat cgctggcagc ctcggctgag cagatgcaca gaggggatca ctgtgcagtg     8460



ggaccaccct cactggcctt ctgcagcagg gttctgggat gttttcagtg gtcaaaatac     8520



tctgtttaga gcaagggctc agaaaacaga aatactgtca tggaggtgct gaacacaggg     8580



aaggtctggt acatattgga aattatgagc agaacaaata ctcaactaaa tgcacaaagt     8640



ataaagtgta gccatgtcta gacaccatgt tgtatcagaa taatttttgt gccaataaat     8700



gacatcagaa ttttaaacat atgtaaaaaa aaa                                  8733





<210>  8

<211>  2549

<212>  PRT

<213>  Homo sapiens



<400>  8



Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 

1               5                   10                  15      





Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 

            20                  25                  30          





Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 

        35                  40                  45              





Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 

    50                  55                  60                  





Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 

65                  70                  75                  80  





Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 

                85                  90                  95      





Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 

            100                 105                 110         





Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 

        115                 120                 125             





Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 

    130                 135                 140                 





Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 

145                 150                 155                 160 





Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 

                165                 170                 175     





Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 

            180                 185                 190         





Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 

        195                 200                 205             





Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 

    210                 215                 220                 





Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 

225                 230                 235                 240 





Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 

                245                 250                 255     





Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 

            260                 265                 270         





Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 

        275                 280                 285             





Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 

    290                 295                 300                 





Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 

305                 310                 315                 320 





Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 

                325                 330                 335     





Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 

            340                 345                 350         





Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 

        355                 360                 365             





Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 

    370                 375                 380                 





Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 

385                 390                 395                 400 





Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 

                405                 410                 415     





Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 

            420                 425                 430         





Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 

        435                 440                 445             





Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 

    450                 455                 460                 





Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 

465                 470                 475                 480 





Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 

                485                 490                 495     





Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 

            500                 505                 510         





Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 

        515                 520                 525             





Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 

    530                 535                 540                 





Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 

545                 550                 555                 560 





Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 

                565                 570                 575     





Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 

            580                 585                 590         





Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 

        595                 600                 605             





His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 

    610                 615                 620                 





Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 

625                 630                 635                 640 





Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 

                645                 650                 655     





Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 

            660                 665                 670         





Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 

        675                 680                 685             





Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 

    690                 695                 700                 





Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 

705                 710                 715                 720 





Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 

                725                 730                 735     





Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 

            740                 745                 750         





Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 

        755                 760                 765             





Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 

    770                 775                 780                 





Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 

785                 790                 795                 800 





Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 

                805                 810                 815     





Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 

            820                 825                 830         





Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 

        835                 840                 845             





Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 

    850                 855                 860                 





Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 

865                 870                 875                 880 





Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 

                885                 890                 895     





Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 

            900                 905                 910         





Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 

        915                 920                 925             





Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 

    930                 935                 940                 





Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 

945                 950                 955                 960 





Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 

                965                 970                 975     





Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 

            980                 985                 990         





Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 

        995                 1000                 1005             





Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 

    1010                 1015                 1020             





Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 

    1025                 1030                 1035             





Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 

    1040                 1045                 1050             





Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 

    1055                 1060                 1065             





Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 

    1070                 1075                 1080             





His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 

    1085                 1090                 1095             





Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 

    1100                 1105                 1110             





Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 

    1115                 1120                 1125             





Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 

    1130                 1135                 1140             





Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 

    1145                 1150                 1155             





Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 

    1160                 1165                 1170             





Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 

    1175                 1180                 1185             





Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 

    1190                 1195                 1200             





Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 

    1205                 1210                 1215             





Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 

    1220                 1225                 1230             





His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 

    1235                 1240                 1245             





Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 

    1250                 1255                 1260             





Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 

    1265                 1270                 1275             





Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 

    1280                 1285                 1290             





Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 

    1295                 1300                 1305             





Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 

    1310                 1315                 1320             





Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 

    1325                 1330                 1335             





Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 

    1340                 1345                 1350             





Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 

    1355                 1360                 1365             





Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 

    1370                 1375                 1380             





Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 

    1385                 1390                 1395             





Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 

    1400                 1405                 1410             





Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 

    1415                 1420                 1425             





Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 

    1430                 1435                 1440             





Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 

    1445                 1450                 1455             





Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 

    1460                 1465                 1470             





Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 

    1475                 1480                 1485             





Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 

    1490                 1495                 1500             





Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 

    1505                 1510                 1515             





Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 

    1520                 1525                 1530             





Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 

    1535                 1540                 1545             





Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 

    1550                 1555                 1560             





Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 

    1565                 1570                 1575             





Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 

    1580                 1585                 1590             





His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 

    1595                 1600                 1605             





Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 

    1610                 1615                 1620             





Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 

    1625                 1630                 1635             





Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 

    1640                 1645                 1650             





Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 

    1655                 1660                 1665             





Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 

    1670                 1675                 1680             





Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 

    1685                 1690                 1695             





Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 

    1700                 1705                 1710             





Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 

    1715                 1720                 1725             





Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 

    1730                 1735                 1740             





His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 

    1745                 1750                 1755             





Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 

    1760                 1765                 1770             





Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 

    1775                 1780                 1785             





Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 

    1790                 1795                 1800             





Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 

    1805                 1810                 1815             





His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 

    1820                 1825                 1830             





Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 

    1835                 1840                 1845             





Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 

    1850                 1855                 1860             





Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 

    1865                 1870                 1875             





Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 

    1880                 1885                 1890             





Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 

    1895                 1900                 1905             





Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 

    1910                 1915                 1920             





Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 

    1925                 1930                 1935             





Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 

    1940                 1945                 1950             





Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 

    1955                 1960                 1965             





Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 

    1970                 1975                 1980             





Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 

    1985                 1990                 1995             





Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 

    2000                 2005                 2010             





Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 

    2015                 2020                 2025             





Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 

    2030                 2035                 2040             





Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 

    2045                 2050                 2055             





Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 

    2060                 2065                 2070             





Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 

    2075                 2080                 2085             





Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 

    2090                 2095                 2100             





Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 

    2105                 2110                 2115             





Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 

    2120                 2125                 2130             





Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 

    2135                 2140                 2145             





Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 

    2150                 2155                 2160             





Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 

    2165                 2170                 2175             





Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 

    2180                 2185                 2190             





Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 

    2195                 2200                 2205             





Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 

    2210                 2215                 2220             





Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 

    2225                 2230                 2235             





Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 

    2240                 2245                 2250             





Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 

    2255                 2260                 2265             





Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 

    2270                 2275                 2280             





Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 

    2285                 2290                 2295             





Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 

    2300                 2305                 2310             





Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 

    2315                 2320                 2325             





Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 

    2330                 2335                 2340             





Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 

    2345                 2350                 2355             





Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 

    2360                 2365                 2370             





Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 

    2375                 2380                 2385             





Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 

    2390                 2395                 2400             





Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 

    2405                 2410                 2415             





Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 

    2420                 2425                 2430             





Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 

    2435                 2440                 2445             





Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 

    2450                 2455                 2460             





Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 

    2465                 2470                 2475             





Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 

    2480                 2485                 2490             





Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 

    2495                 2500                 2505             





Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 

    2510                 2515                 2520             





Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 

    2525                 2530                 2535             





Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 

    2540                 2545                 





<210>  9

<211>  1890

<212>  DNA

<213>  Homo sapiens



<400>  9

aggagccgcc gccagtggag ggccgggcgc tgcggccgcg gccggggcgg gcgcagggcc       60



gagcggacgg gggggcgcgg gccccccggg aggccgcggc cactcccccc cgggccggcg      120



cggcggggga ggcggaggat ggaaacaccc ttctacggcg atgaggcgct gagcggcctg      180



ggcggcggcg ccagtggcag cggcggcagc ttcgcgtccc cgggccgctt gttccccggg      240



gcgcccccga cggccgcggc cggcagcatg atgaagaagg acgcgctgac gctgagcctg      300



agtgagcagg tggcggcagc gctcaagcct gcggccgcgc cgcctcctac ccccctgcgc      360



gccgacggcg cccccagcgc ggcacccccc gacggcctgc tcgcctctcc cgacctgggg      420



ctgctgaagc tggcctcccc cgagctcgag cgcctcatca tccagtccaa cgggctggtc      480



accaccacgc cgacgagctc acagttcctc taccccaagg tggcggccag cgaggagcag      540



gagttcgccg agggcttcgt caaggccctg gaggatttac acaagcagaa ccagctcggc      600



gcgggcgcgg ccgctgccgc cgccgccgcc gccgccgggg ggccctcggg cacggccacg      660



ggctccgcgc cccccggcga gctggccccg gcggcggccg cgcccgaagc gcctgtctac      720



gcgaacctga gcagctacgc gggcggcgcc gggggcgcgg ggggcgccgc gacggtcgcc      780



ttcgctgccg aacctgtgcc cttcccgccg ccgccacccc caggcgcgtt ggggccgccg      840



cgcctggctg cgctcaagga cgagccacag acggtgcccg acgtgccgag cttcggcgag      900



agcccgccgt tgtcgcccat cgacatggac acgcaggagc gcatcaaggc ggagcgcaag      960



cggctgcgca accgcatcgc cgcctccaag tgccgcaagc gcaagctgga gcgcatctcg     1020



cgcctggaag agaaagtgaa gaccctcaag agtcagaaca cggagctggc gtccacggcg     1080



agcctgctgc gcgagcaggt ggcgcagctc aagcagaaag tcctcagcca cgtcaacagc     1140



ggctgccagc tgctgcccca gcaccaggtg cccgcgtact gagtccgcgc gcggggcgca     1200



tgcgcggcca ccctccccaa ggggcgggct cgcggggggg tgtcgtgggc gccccggact     1260



tggagagggt gcggccctgg ggaccccccc tccccgagtg tgcccaggaa ctcagagagg     1320



gcgcggcccc cggggattcc ccccccccga gggtgcccag gactcgacaa gctggacccc     1380



ctgctcccgg gggggcgagc gcatgacccc cccgccctcg cgctgcctct ttcccccgcg     1440



cggccgcccc gtgttgcaca aacccgcgcg tctcggctgc ccctttgtac accgcgccgc     1500



ggaagggggc tccgaggggg cgcagcctca aaccctgcct ttcctttact tttacttttt     1560



tttttttttc tttggaagag agaagaacag agtgttcgat tctgccctat ttatgtttct     1620



actcgggaac aaacgttggt tgtgtgtgtg tgtgttttct tgtgttggtt ttttaaagaa     1680



atgggaagaa gaaaaaaaaa ttctccgccc ctttcctcga tctcgctccc cccttcggtt     1740



ctttcgaccg gtcccccctc ccttttttgt tctgttttgt tttgttttgc tacgagtcca     1800



cattcctgtt tgtaatcctt ggttcgcccg gttttctgtt ttcagtaaag tctcgttacg     1860



ccagctcggc aaaaaaaaaa aaaaaaaaaa                                      1890





<210>  10

<211>  347

<212>  PRT

<213>  Homo sapiens



<400>  10



Met Glu Thr Pro Phe Tyr Gly Asp Glu Ala Leu Ser Gly Leu Gly Gly 

1               5                   10                  15      





Gly Ala Ser Gly Ser Gly Gly Ser Phe Ala Ser Pro Gly Arg Leu Phe 

            20                  25                  30          





Pro Gly Ala Pro Pro Thr Ala Ala Ala Gly Ser Met Met Lys Lys Asp 

        35                  40                  45              





Ala Leu Thr Leu Ser Leu Ser Glu Gln Val Ala Ala Ala Leu Lys Pro 

    50                  55                  60                  





Ala Ala Ala Pro Pro Pro Thr Pro Leu Arg Ala Asp Gly Ala Pro Ser 

65                  70                  75                  80  





Ala Ala Pro Pro Asp Gly Leu Leu Ala Ser Pro Asp Leu Gly Leu Leu 

                85                  90                  95      





Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile Ile Gln Ser Asn Gly 

            100                 105                 110         





Leu Val Thr Thr Thr Pro Thr Ser Ser Gln Phe Leu Tyr Pro Lys Val 

        115                 120                 125             





Ala Ala Ser Glu Glu Gln Glu Phe Ala Glu Gly Phe Val Lys Ala Leu 

    130                 135                 140                 





Glu Asp Leu His Lys Gln Asn Gln Leu Gly Ala Gly Ala Ala Ala Ala 

145                 150                 155                 160 





Ala Ala Ala Ala Ala Ala Gly Gly Pro Ser Gly Thr Ala Thr Gly Ser 

                165                 170                 175     





Ala Pro Pro Gly Glu Leu Ala Pro Ala Ala Ala Ala Pro Glu Ala Pro 

            180                 185                 190         





Val Tyr Ala Asn Leu Ser Ser Tyr Ala Gly Gly Ala Gly Gly Ala Gly 

        195                 200                 205             





Gly Ala Ala Thr Val Ala Phe Ala Ala Glu Pro Val Pro Phe Pro Pro 

    210                 215                 220                 





Pro Pro Pro Pro Gly Ala Leu Gly Pro Pro Arg Leu Ala Ala Leu Lys 

225                 230                 235                 240 





Asp Glu Pro Gln Thr Val Pro Asp Val Pro Ser Phe Gly Glu Ser Pro 

                245                 250                 255     





Pro Leu Ser Pro Ile Asp Met Asp Thr Gln Glu Arg Ile Lys Ala Glu 

            260                 265                 270         





Arg Lys Arg Leu Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 

        275                 280                 285             





Lys Leu Glu Arg Ile Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 

    290                 295                 300                 





Ser Gln Asn Thr Glu Leu Ala Ser Thr Ala Ser Leu Leu Arg Glu Gln 

305                 310                 315                 320 





Val Ala Gln Leu Lys Gln Lys Val Leu Ser His Val Asn Ser Gly Cys 

                325                 330                 335     





Gln Leu Leu Pro Gln His Gln Val Pro Ala Tyr 

            340                 345         





<210>  11

<211>  3291

<212>  DNA

<213>  Homo sapiens



<400>  11

agaatcggag agccggtggc gtcgcaggtc gggaggacga gcaccgagtc gagggctcgc       60



tcgtctgggc cgcccgagag tcttaatcgc gggcgcttgg gccgccatct tagatggcgg      120



gagtaagagg aaaacgattg tgaggcggga acggctttct gctgcctttt ttgggccccg      180



aaaagggtca gctggccggg ctttggggcg cgtgccctga ggcgcggagc gcgtttgcta      240



cgatgcgggg gctgctcggg gctccgtccc ctgggctggg gacgcgccga atgtgaccgc      300



ctcccgctcc ctcacccgcc gcggggagga ggagcgggcg agaagctgcc gccgaacgac      360



aggacgttgg ggcggcctgg ctccctcagg tttaagaatt gtttaagctg catcaatgga      420



gcacatacag ggagcttgga agacgatcag caatggtttt ggattcaaag atgccgtgtt      480



tgatggctcc agctgcatct ctcctacaat agttcagcag tttggctatc agcgccgggc      540



atcagatgat ggcaaactca cagatccttc taagacaagc aacactatcc gtgttttctt      600



gccgaacaag caaagaacag tggtcaatgt gcgaaatgga atgagcttgc atgactgcct      660



tatgaaagca ctcaaggtga ggggcctgca accagagtgc tgtgcagtgt tcagacttct      720



ccacgaacac aaaggtaaaa aagcacgctt agattggaat actgatgctg cgtctttgat      780



tggagaagaa cttcaagtag atttcctgga tcatgttccc ctcacaacac acaactttgc      840



tcggaagacg ttcctgaagc ttgccttctg tgacatctgt cagaaattcc tgctcaatgg      900



atttcgatgt cagacttgtg gctacaaatt tcatgagcac tgtagcacca aagtacctac      960



tatgtgtgtg gactggagta acatcagaca actcttattg tttccaaatt ccactattgg     1020



tgatagtgga gtcccagcac taccttcttt gactatgcgt cgtatgcgag agtctgtttc     1080



caggatgcct gttagttctc agcacagata ttctacacct cacgccttca cctttaacac     1140



ctccagtccc tcatctgaag gttccctctc ccagaggcag aggtcgacat ccacacctaa     1200



tgtccacatg gtcagcacca ccctgcctgt ggacagcagg atgattgagg atgcaattcg     1260



aagtcacagc gaatcagcct caccttcagc cctgtccagt agccccaaca atctgagccc     1320



aacaggctgg tcacagccga aaacccccgt gccagcacaa agagagcggg caccagtatc     1380



tgggacccag gagaaaaaca aaattaggcc tcgtggacag agagattcaa gctattattg     1440



ggaaatagaa gccagtgaag tgatgctgtc cactcggatt gggtcaggct cttttggaac     1500



tgtttataag ggtaaatggc acggagatgt tgcagtaaag atcctaaagg ttgtcgaccc     1560



aaccccagag caattccagg ccttcaggaa tgaggtggct gttctgcgca aaacacggca     1620



tgtgaacatt ctgcttttca tggggtacat gacaaaggac aacctggcaa ttgtgaccca     1680



gtggtgcgag ggcagcagcc tctacaaaca cctgcatgtc caggagacca agtttcagat     1740



gttccagcta attgacattg cccggcagac ggctcaggga atggactatt tgcatgcaaa     1800



gaacatcatc catagagaca tgaaatccaa caatatattt ctccatgaag gcttaacagt     1860



gaaaattgga gattttggtt tggcaacagt aaagtcacgc tggagtggtt ctcagcaggt     1920



tgaacaacct actggctctg tcctctggat ggccccagag gtgatccgaa tgcaggataa     1980



caacccattc agtttccagt cggatgtcta ctcctatggc atcgtattgt atgaactgat     2040



gacgggggag cttccttatt ctcacatcaa caaccgagat cagatcatct tcatggtggg     2100



ccgaggatat gcctccccag atcttagtaa gctatataag aactgcccca aagcaatgaa     2160



gaggctggta gctgactgtg tgaagaaagt aaaggaagag aggcctcttt ttccccagat     2220



cctgtcttcc attgagctgc tccaacactc tctaccgaag atcaaccgga gcgcttccga     2280



gccatccttg catcgggcag cccacactga ggatatcaat gcttgcacgc tgaccacgtc     2340



cccgaggctg cctgtcttct agttgacttt gcacctgtct tcaggctgcc aggggaggag     2400



gagaagccag caggcaccac ttttctgctc cctttctcca gaggcagaac acatgttttc     2460



agagaagctg ctgctaagga ccttctagac tgctcacagg gccttaactt catgttgcct     2520



tcttttctat ccctttgggc cctgggagaa ggaagccatt tgcagtgctg gtgtgtcctg     2580



ctccctcccc acattcccca tgctcaaggc ccagccttct gtagatgcgc aagtggatgt     2640



tgatggtagt acaaaaagca ggggcccagc cccagctgtt ggctacatga gtatttagag     2700



gaagtaaggt agcaggcagt ccagccctga tgtggagaca catgggattt tggaaatcag     2760



cttctggagg aatgcatgtc acaggcggga ctttcttcag agagtggtgc agcgccagac     2820



attttgcaca taaggcacca aacagcccag gactgccgag actctggccg cccgaaggag     2880



cctgctttgg tactatggaa cttttcttag gggacacgtc ctcctttcac agcttctaag     2940



gtgtccagtg cattgggatg gttttccagg caaggcactc ggccaatccg catctcagcc     3000



ctctcaggga gcagtcttcc atcatgctga attttgtctt ccaggagctg cccctatggg     3060



gcggggccgc agggccagcc ttgtttctct aacaaacaaa caaacaaaca gccttgtttc     3120



tctagtcaca tcatgtgtat acaaggaagc caggaataca ggttttcttg atgatttggg     3180



ttttaatttt gtttttattg cacctgacaa aatacagtta tctgatggtc cctcaattat     3240



gttattttaa taaaataaat taaatttagg tgtaaaaaaa aaaaaaaaaa a              3291





<210>  12

<211>  648

<212>  PRT

<213>  Homo sapiens



<400>  12



Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 

1               5                   10                  15      





Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 

            20                  25                  30          





Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 

        35                  40                  45              





Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 

    50                  55                  60                  





Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 

65                  70                  75                  80  





Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 

                85                  90                  95      





Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 

            100                 105                 110         





Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 

        115                 120                 125             





Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 

    130                 135                 140                 





Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 

145                 150                 155                 160 





Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 

                165                 170                 175     





Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 

            180                 185                 190         





Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala 

        195                 200                 205             





Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 

    210                 215                 220                 





Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 

225                 230                 235                 240 





Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 

                245                 250                 255     





Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 

            260                 265                 270         





Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 

        275                 280                 285             





Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 

    290                 295                 300                 





Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 

305                 310                 315                 320 





Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 

                325                 330                 335     





Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 

            340                 345                 350         





Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 

        355                 360                 365             





His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 

    370                 375                 380                 





Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 

385                 390                 395                 400 





Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 

                405                 410                 415     





Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 

            420                 425                 430         





Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 

        435                 440                 445             





Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 

    450                 455                 460                 





Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 

465                 470                 475                 480 





Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 

                485                 490                 495     





Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 

            500                 505                 510         





Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 

        515                 520                 525             





Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 

    530                 535                 540                 





Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 

545                 550                 555                 560 





Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn 

                565                 570                 575     





Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 

            580                 585                 590         





Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 

        595                 600                 605             





Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 

    610                 615                 620                 





Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 

625                 630                 635                 640 





Thr Ser Pro Arg Leu Pro Val Phe 

                645             





<210>  13

<211>  2381

<212>  DNA

<213>  Homo sapiens



<400>  13

ggagtaacag tgtcgccgcc gccttcctcc tcctcctctc gccgctaccg ccgtcgccgc       60



cgccgcagcc gccgccggtc cgcgcggcct cgggtggccg gagctcagcc tgcgcgcgcc      120



gcgccctgtg tctccgggtg gggcagaaga ctcgcccctt gaacctcccg cggggactct      180



ccgtggtgtg gcggccctgg ggctctttct taatagcccc ggactgagtc ccctccagtc      240



gaggaccctc tcctagtcca ctgacgagcg gtggacacct gccgctgtat ctcccccaaa      300



ccgagtcctt gccctgctgc ctcctcatac ccacacggcg gcagagacct tcaccatagc      360



gttcgctcaa ctccagaacc ttccgacctc cgctagttcc tgcgggcctt tgcccgcttc      420



ccggtgcacc ctccccggga gacacctcag acccccgaca gcctgggcag gctcggtgcc      480



tgcgggtgcg ttcctgatca cccctcccct cttccctccc cctcatcctc cattcccttg      540



ttttcaccct ctgtcctctg cccgtcactc cccttgtcac ctcttggagc cccctcctaa      600



ccagcggcca gtgggtttcc cataccccag gatgtgagcc tctttaacct gtaatgctgt      660



ggctagccct tggccccttt cctgccatgg agaaccaggt gctggtaatt cgcatcaaga      720



tcccaaatag tggcgcggtg gactggacag tgcactccgg gccgcagtta ctcttcaggg      780



atgtgctgga tgtgataggc caggttctgc ctgaagcaac aactacagca tttgaatatg      840



aagatgaaga tggtgatcga attacagtga gaagtgatga ggaaatgaag gcaatgctgt      900



catattatta ttccacagta atggaacagc aagtaaatgg acagttaata gagcctctgc      960



agatatttcc aagagcctgc aagcctcctg gggaacggaa catacatggc ctgaaggtga     1020



atactcgggc cggaccctct caacacagca gcccagcagt ctcagattca cttccaagca     1080



atagcttaaa gaagtcttct gctgaactga aaaaaatact agccaatggc cagatgaatg     1140



aacaagacat acgatatcgg gacactcttg gtcatggcaa cggaggcaca gtctacaaag     1200



catatcatgt cccgagtggg aaaatattag ctgtaaaggt catactacta gatattacac     1260



tggaacttca gaagcaaatt atgtctgaat tggaaattct ttataagtgc gattcatcat     1320



atatcattgg attttatgga gcattttttg tagaaaacag gatttcaata tgtacagaat     1380



tcatggatgg gggatctttg gatgtatata ggaaaatgcc agaacatgtc cttggaagaa     1440



ttgcagtagc agttgttaaa ggccttactt atttgtggag tttaaagatt ttacatagag     1500



acgtgaagcc ctccaatatg ctagtaaaca caagaggaca ggttaagctg tgtgattttg     1560



gagttagcac tcagctggtg aattctatag ccaagacgta tgttggaaca aatgcttata     1620



tggcgcctga aaggatttca ggggagcagt atggaattca ttctgatgtc tggagcttag     1680



gaatctcttt tatggagctt gctcttggga ggtttccata tcctcagatt cagaaaaacc     1740



agggatcttt aatgcctctc cagcttctgc agtgcattgt tgatgaggat tcgcccgtcc     1800



ttccagttgg agagttctcg gagccatttg tacatttcat cactcagtgt atgcgaaaac     1860



agccaaaaga aaggccagca cctgaagaat tgatgggcca cccgttcatc gtgcagttca     1920



atgatggaaa tgccgccgtg gtgtccatgt gggtgtgccg ggcgctggag gagaggcgga     1980



gccagcaggg gcccccgtga ggctgccgca gggcactgaa agcccaggac cagtaaccaa     2040



ggagaacaac ccacccgtcg cccttctccg tatgctgcct gcgccagaag agctttgctg     2100



ggccctggct tccctgccct cgccttcacc tctgtcagca ggtggccttg cctggggagc     2160



cccatgtgtg gcccacccca ccaggccatc cccatacctt ctggtttgaa ggcgctgaca     2220



ctggcagaga ggtaaagggt ggggcattga gaatggaggc tcccagggtc cctgcccact     2280



tctgttttcc taatgttttt ctctataaag ggtcaggccc gtcagcatca ctgatgggaa     2340



taaaagtatt aatgctttgt gacaaaaaaa aaaaaaaaaa a                         2381





<210>  14

<211>  448

<212>  PRT

<213>  Homo sapiens



<400>  14



Met Leu Trp Leu Ala Leu Gly Pro Phe Pro Ala Met Glu Asn Gln Val 

1               5                   10                  15      





Leu Val Ile Arg Ile Lys Ile Pro Asn Ser Gly Ala Val Asp Trp Thr 

            20                  25                  30          





Val His Ser Gly Pro Gln Leu Leu Phe Arg Asp Val Leu Asp Val Ile 

        35                  40                  45              





Gly Gln Val Leu Pro Glu Ala Thr Thr Thr Ala Phe Glu Tyr Glu Asp 

    50                  55                  60                  





Glu Asp Gly Asp Arg Ile Thr Val Arg Ser Asp Glu Glu Met Lys Ala 

65                  70                  75                  80  





Met Leu Ser Tyr Tyr Tyr Ser Thr Val Met Glu Gln Gln Val Asn Gly 

                85                  90                  95      





Gln Leu Ile Glu Pro Leu Gln Ile Phe Pro Arg Ala Cys Lys Pro Pro 

            100                 105                 110         





Gly Glu Arg Asn Ile His Gly Leu Lys Val Asn Thr Arg Ala Gly Pro 

        115                 120                 125             





Ser Gln His Ser Ser Pro Ala Val Ser Asp Ser Leu Pro Ser Asn Ser 

    130                 135                 140                 





Leu Lys Lys Ser Ser Ala Glu Leu Lys Lys Ile Leu Ala Asn Gly Gln 

145                 150                 155                 160 





Met Asn Glu Gln Asp Ile Arg Tyr Arg Asp Thr Leu Gly His Gly Asn 

                165                 170                 175     





Gly Gly Thr Val Tyr Lys Ala Tyr His Val Pro Ser Gly Lys Ile Leu 

            180                 185                 190         





Ala Val Lys Val Ile Leu Leu Asp Ile Thr Leu Glu Leu Gln Lys Gln 

        195                 200                 205             





Ile Met Ser Glu Leu Glu Ile Leu Tyr Lys Cys Asp Ser Ser Tyr Ile 

    210                 215                 220                 





Ile Gly Phe Tyr Gly Ala Phe Phe Val Glu Asn Arg Ile Ser Ile Cys 

225                 230                 235                 240 





Thr Glu Phe Met Asp Gly Gly Ser Leu Asp Val Tyr Arg Lys Met Pro 

                245                 250                 255     





Glu His Val Leu Gly Arg Ile Ala Val Ala Val Val Lys Gly Leu Thr 

            260                 265                 270         





Tyr Leu Trp Ser Leu Lys Ile Leu His Arg Asp Val Lys Pro Ser Asn 

        275                 280                 285             





Met Leu Val Asn Thr Arg Gly Gln Val Lys Leu Cys Asp Phe Gly Val 

    290                 295                 300                 





Ser Thr Gln Leu Val Asn Ser Ile Ala Lys Thr Tyr Val Gly Thr Asn 

305                 310                 315                 320 





Ala Tyr Met Ala Pro Glu Arg Ile Ser Gly Glu Gln Tyr Gly Ile His 

                325                 330                 335     





Ser Asp Val Trp Ser Leu Gly Ile Ser Phe Met Glu Leu Ala Leu Gly 

            340                 345                 350         





Arg Phe Pro Tyr Pro Gln Ile Gln Lys Asn Gln Gly Ser Leu Met Pro 

        355                 360                 365             





Leu Gln Leu Leu Gln Cys Ile Val Asp Glu Asp Ser Pro Val Leu Pro 

    370                 375                 380                 





Val Gly Glu Phe Ser Glu Pro Phe Val His Phe Ile Thr Gln Cys Met 

385                 390                 395                 400 





Arg Lys Gln Pro Lys Glu Arg Pro Ala Pro Glu Glu Leu Met Gly His 

                405                 410                 415     





Pro Phe Ile Val Gln Phe Asn Asp Gly Asn Ala Ala Val Val Ser Met 

            420                 425                 430         





Trp Val Cys Arg Ala Leu Glu Glu Arg Arg Ser Gln Gln Gly Pro Pro 

        435                 440                 445             





<210>  15

<211>  2334

<212>  DNA

<213>  Homo sapiens



<400>  15

ggagtaacag tgtcgccgcc gccttcctcc tcctcctctc gccgctaccg ccgtcgccgc       60



cgccgcagcc gccgccggtc cgcgcggcct cgggtggccg gagctcagcc tgcgcgcgcc      120



gcgccctgtg tctccgggtg gggcagaaga ctcgcccctt gaacctcccg cggggactct      180



ccgtggtgtg gcggccctgg ggctctttct taatagcccc ggactgagtc ccctccagtc      240



gaggaccctc tcctagtcca ctgacgagcg gtggacacct gccgctgtat ctcccccaaa      300



ccgagtcctt gccctgctgc ctcctcatac ccacacggcg gcagagacct tcaccatagc      360



gttcgctcaa ctccagaacc ttccgacctc cgctagttcc tgcgggcctt tgcccgcttc      420



ccggtgcacc ctccccggga gacacctcag acccccgaca gcctgggcag gctcggtgcc      480



tgcgggtgcg ttcctgatca cccctcccct cttccctccc cctcatcctc cattcccttg      540



ttttcaccct ctgtcctctg cccgtcactc cccttgtcac ctcttggagc cccctcctaa      600



ccagcggcca gtgggtttcc cataccccag gatgtgagcc tctttaacct gtaatgctgt      660



ggctagccct tggccccttt cctgccatgg agaaccaggt gctggtaatt cgcatcaaga      720



tcccaaatag tggcgcggtg gactggacag tgcactccgg gccgcagtta ctcttcaggg      780



atgtgctgga tgtgataggc caggttctgc ctgaagcaac aactacagca tttgaatatg      840



aagatgaaga tggtgatcga attacagtga gaagtgatga ggaaatgaag gcaatgctgt      900



catattatta ttccacagta atggaacagc aagtaaatgg acagttaata gagcctctgc      960



agatatttcc aagagcctgc aagcctcctg gggaacggaa catacatggc ctgaaggtga     1020



atactcgggc cggaccctct caacacagca gcccagcagt ctcagattca cttccaagca     1080



atagcttaaa gaagtcttct gctgaactga aaaaaatact agccaatggc cagatgaatg     1140



aacaagacat acgatatcgg gacactcttg gtcatggcaa cggaggcaca gtctacaaag     1200



catatcatgt cccgagtggg aaaatattag ctgtaaaggt catactacta gatattacac     1260



tggaacttca gaagcaaatt atgtctgaat tggaaattct ttataagtgc gattcatcat     1320



atatcattgg attttatgga gcattttttg tagaaaacag gatttcaata tgtacagaat     1380



tcatggatgg gggatctttg gatgtatata ggaaaatgcc agaacatgtc cttggaagaa     1440



ttgcagtagc agttgttaaa ggccttactt atttgtggag tttaaagatt ttacatagag     1500



acgtgaagcc ctccaatatg ctagtaaaca caagaggaca ggttaagctg tgtgattttg     1560



gagttagcac tcagctggtg aattctatag ccaagacgta tgttggaaca aatgcttata     1620



tggcgcctga aaggatttca ggggagcagt atggaattca ttctgatgtc tggagcttag     1680



gaatctcttt tatggagatt cagaaaaacc agggatcttt aatgcctctc cagcttctgc     1740



agtgcattgt tgatgaggat tcgcccgtcc ttccagttgg agagttctcg gagccatttg     1800



tacatttcat cactcagtgt atgcgaaaac agccaaaaga aaggccagca cctgaagaat     1860



tgatgggcca cccgttcatc gtgcagttca atgatggaaa tgccgccgtg gtgtccatgt     1920



gggtgtgccg ggcgctggag gagaggcgga gccagcaggg gcccccgtga ggctgccgca     1980



gggcactgaa agcccaggac cagtaaccaa ggagaacaac ccacccgtcg cccttctccg     2040



tatgctgcct gcgccagaag agctttgctg ggccctggct tccctgccct cgccttcacc     2100



tctgtcagca ggtggccttg cctggggagc cccatgtgtg gcccacccca ccaggccatc     2160



cccatacctt ctggtttgaa ggcgctgaca ctggcagaga ggtaaagggt ggggcattga     2220



gaatggaggc tcccagggtc cctgcccact tctgttttcc taatgttttt ctctataaag     2280



ggtcaggccc gtcagcatca ctgatgggaa taaaagtatt aatgctttgt gaca           2334





<210>  16

<211>  438

<212>  PRT

<213>  Homo sapiens



<400>  16



Met Leu Trp Leu Ala Leu Gly Pro Phe Pro Ala Met Glu Asn Gln Val 

1               5                   10                  15      





Leu Val Ile Arg Ile Lys Ile Pro Asn Ser Gly Ala Val Asp Trp Thr 

            20                  25                  30          





Val His Ser Gly Pro Gln Leu Leu Phe Arg Asp Val Leu Asp Val Ile 

        35                  40                  45              





Gly Gln Val Leu Pro Glu Ala Thr Thr Thr Ala Phe Glu Tyr Glu Asp 

    50                  55                  60                  





Glu Asp Gly Asp Arg Ile Thr Val Arg Ser Asp Glu Glu Met Lys Ala 

65                  70                  75                  80  





Met Leu Ser Tyr Tyr Tyr Ser Thr Val Met Glu Gln Gln Val Asn Gly 

                85                  90                  95      





Gln Leu Ile Glu Pro Leu Gln Ile Phe Pro Arg Ala Cys Lys Pro Pro 

            100                 105                 110         





Gly Glu Arg Asn Ile His Gly Leu Lys Val Asn Thr Arg Ala Gly Pro 

        115                 120                 125             





Ser Gln His Ser Ser Pro Ala Val Ser Asp Ser Leu Pro Ser Asn Ser 

    130                 135                 140                 





Leu Lys Lys Ser Ser Ala Glu Leu Lys Lys Ile Leu Ala Asn Gly Gln 

145                 150                 155                 160 





Met Asn Glu Gln Asp Ile Arg Tyr Arg Asp Thr Leu Gly His Gly Asn 

                165                 170                 175     





Gly Gly Thr Val Tyr Lys Ala Tyr His Val Pro Ser Gly Lys Ile Leu 

            180                 185                 190         





Ala Val Lys Val Ile Leu Leu Asp Ile Thr Leu Glu Leu Gln Lys Gln 

        195                 200                 205             





Ile Met Ser Glu Leu Glu Ile Leu Tyr Lys Cys Asp Ser Ser Tyr Ile 

    210                 215                 220                 





Ile Gly Phe Tyr Gly Ala Phe Phe Val Glu Asn Arg Ile Ser Ile Cys 

225                 230                 235                 240 





Thr Glu Phe Met Asp Gly Gly Ser Leu Asp Val Tyr Arg Lys Met Pro 

                245                 250                 255     





Glu His Val Leu Gly Arg Ile Ala Val Ala Val Val Lys Gly Leu Thr 

            260                 265                 270         





Tyr Leu Trp Ser Leu Lys Ile Leu His Arg Asp Val Lys Pro Ser Asn 

        275                 280                 285             





Met Leu Val Asn Thr Arg Gly Gln Val Lys Leu Cys Asp Phe Gly Val 

    290                 295                 300                 





Ser Thr Gln Leu Val Asn Ser Ile Ala Lys Thr Tyr Val Gly Thr Asn 

305                 310                 315                 320 





Ala Tyr Met Ala Pro Glu Arg Ile Ser Gly Glu Gln Tyr Gly Ile His 

                325                 330                 335     





Ser Asp Val Trp Ser Leu Gly Ile Ser Phe Met Glu Ile Gln Lys Asn 

            340                 345                 350         





Gln Gly Ser Leu Met Pro Leu Gln Leu Leu Gln Cys Ile Val Asp Glu 

        355                 360                 365             





Asp Ser Pro Val Leu Pro Val Gly Glu Phe Ser Glu Pro Phe Val His 

    370                 375                 380                 





Phe Ile Thr Gln Cys Met Arg Lys Gln Pro Lys Glu Arg Pro Ala Pro 

385                 390                 395                 400 





Glu Glu Leu Met Gly His Pro Phe Ile Val Gln Phe Asn Asp Gly Asn 

                405                 410                 415     





Ala Ala Val Val Ser Met Trp Val Cys Arg Ala Leu Glu Glu Arg Arg 

            420                 425                 430         





Ser Gln Gln Gly Pro Pro 

        435             





<210>  17

<211>  3077

<212>  DNA

<213>  Homo sapiens



<400>  17

gagcggacag gcgtggcggc cggagcccca gcatccctgc ttgaggtcca ggagcggagc       60



ccgcggccac cgccgcctga tcagcgcgac cccggcccgc gcccgccccg cccggcaaga      120



tgctgcccgt gtaccaggag gtgaagccca acccgctgca ggacgcgaac ctctgctcac      180



gcgtgttctt ctggtggctc aatcccttgt ttaaaattgg ccataaacgg agattagagg      240



aagatgatat gtattcagtg ctgccagaag accgctcaca gcaccttgga gaggagttgc      300



aagggttctg ggataaagaa gttttaagag ctgagaatga cgcacagaag ccttctttaa      360



caagagcaat cataaagtgt tactggaaat cttatttagt tttgggaatt tttacgttaa      420



ttgaggaaag tgccaaagta atccagccca tatttttggg aaaaattatt aattattttg      480



aaaattatga tcccatggat tctgtggctt tgaacacagc gtacgcctat gccacggtgc      540



tgactttttg cacgctcatt ttggctatac tgcatcactt atatttttat cacgttcagt      600



gtgctgggat gaggttacga gtagccatgt gccatatgat ttatcggaag gcacttcgtc      660



ttagtaacat ggccatgggg aagacaacca caggccagat agtcaatctg ctgtccaatg      720



atgtgaacaa gtttgatcag gtgacagtgt tcttacactt cctgtgggca ggaccactgc      780



aggcgattgc agtgactgcc ctactctgga tggagatagg aatatcgtgc cttgctggga      840



tggcagttct aatcattctc ctgcccttgc aaagctgttt tgggaagttg ttctcatcac      900



tgaggagtaa aactgcaact ttcacggatg ccaggatcag gaccatgaat gaagttataa      960



ctggtataag gataataaaa atgtacgcct gggaaaagtc attttcaaat cttattacca     1020



atttgagaaa gaaggagatt tccaagattc tgagaagttc ctgcctcaga gggatgaatt     1080



tggcttcatt tttcagtgca agcaaaatca tcgtgtttgt gaccttcacc acctacgtgc     1140



tcctcggcag tgtgatcaca gccagccgcg tgttcgtggc agtgacgctg tatggggctg     1200



tgcggctgac ggttaccctc ttcttcccct cagccattga gagggtgtca gaggcaatcg     1260



tcagcatccg aagaatccag acctttttgc tacttgatga gatatcacag cgcaaccgtc     1320



agctgccgtc agatggtaaa aagatggtgc atgtgcagga ttttactgct ttttgggata     1380



aggcatcaga gaccccaact ctacaaggcc tttcctttac tgtcagacct ggcgaattgt     1440



tagctgtggt cggccccgtg ggagcaggga agtcatcact gttaagtgcc gtgctcgggg     1500



aattggcccc aagtcacggg ctggtcagcg tgcatggaag aattgcctat gtgtctcagc     1560



agccctgggt gttctcggga actctgagga gtaatatttt atttgggaag aaatacgaaa     1620



aggaacgata tgaaaaagtc ataaaggctt gtgctctgaa aaaggattta cagctgttgg     1680



aggatggtga tctgactgtg ataggagatc ggggaaccac gctgagtgga gggcagaaag     1740



cacgggtaaa ccttgcaaga gcagtgtatc aagatgctga catctatctc ctggacgatc     1800



ctctcagtgc agtagatgcg gaagttagca gacacttgtt cgaactgtgt atttgtcaaa     1860



ttttgcatga gaagatcaca attttagtga ctcatcagtt gcagtacctc aaagctgcaa     1920



gtcagattct gatattgaaa gatggtaaaa tggtgcagaa ggggacttac actgagttcc     1980



taaaatctgg tatagatttt ggctcccttt taaagaagga taatgaggaa agtgaacaac     2040



ctccagttcc aggaactccc acactaagga atcgtacctt ctcagagtct tcggtttggt     2100



ctcaacaatc ttctagaccc tccttgaaag atggtgctct ggagagccaa gatacagaga     2160



atgtcccagt tacactatca gaggagaacc gttctgaagg aaaagttggt tttcaggcct     2220



ataagaatta cttcagagct ggtgctcact ggattgtctt cattttcctt attctcctaa     2280



acactgcagc tcaggttgcc tatgtgcttc aagattggtg gctttcatac tgggcaaaca     2340



aacaaagtat gctaaatgtc actgtaaatg gaggaggaaa tgtaaccgag aagctagatc     2400



ttaactggta cttaggaatt tattcaggtt taactgtagc taccgttctt tttggcatag     2460



caagatctct attggtattc tacgtccttg ttaactcttc acaaactttg cacaacaaaa     2520



tgtttgagtc aattctgaaa gctccggtat tattctttga tagaaatcca ataggaagaa     2580



ttttaaatcg tttctccaaa gacattggac acttggatga tttgctgccg ctgacgtttt     2640



tagatttcat ccagagatgg gatctcgctg tgttgtcctg gctggtctca aactcctagg     2700



ctcaagcaat cctcctccct cctcaagcaa acctcagtgc tgggattata ggcatgagcc     2760



actgtacctg gctaaatgtt gtttttttga tattcaattt ttgtttatag aattttcatt     2820



tgttttgctc ttatactttt catcttttta tgtttattga ccaattaaat atcatttggg     2880



taagcaccta tttaagtgtc ttaacaattt ttctattgag tactctgggt ttttgttttg     2940



tttttcttac tgatttgtag aattctttat gtattctgaa ttgcagatac cttccttctg     3000



tactaatgct tatcttttta gccctgtaat attgtgtttt cataaacata cttatcaatc     3060



tttaaaaaaa aaaaaaa                                                    3077





<210>  18

<211>  859

<212>  PRT

<213>  Homo sapiens



<400>  18



Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 

1               5                   10                  15      





Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 

            20                  25                  30          





Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 

        35                  40                  45              





Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 

    50                  55                  60                  





Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 

65                  70                  75                  80  





Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 

                85                  90                  95      





Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 

            100                 105                 110         





Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 

        115                 120                 125             





Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 

    130                 135                 140                 





Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 

145                 150                 155                 160 





Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 

                165                 170                 175     





Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 

            180                 185                 190         





Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 

        195                 200                 205             





Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 

    210                 215                 220                 





Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 

225                 230                 235                 240 





Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 

                245                 250                 255     





Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 

            260                 265                 270         





Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 

        275                 280                 285             





Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 

    290                 295                 300                 





Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 

305                 310                 315                 320 





Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 

                325                 330                 335     





Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 

            340                 345                 350         





Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 

        355                 360                 365             





Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 

    370                 375                 380                 





Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 

385                 390                 395                 400 





Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 

                405                 410                 415     





Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 

            420                 425                 430         





Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 

        435                 440                 445             





Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 

    450                 455                 460                 





Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 

465                 470                 475                 480 





Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 

                485                 490                 495     





Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 

            500                 505                 510         





Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 

        515                 520                 525             





Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 

    530                 535                 540                 





Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 

545                 550                 555                 560 





Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 

                565                 570                 575     





Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 

            580                 585                 590         





Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 

        595                 600                 605             





Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 

    610                 615                 620                 





Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 

625                 630                 635                 640 





Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 

                645                 650                 655     





Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 

            660                 665                 670         





Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 

        675                 680                 685             





Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 

    690                 695                 700                 





Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 

705                 710                 715                 720 





Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 

                725                 730                 735     





Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 

            740                 745                 750         





Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 

        755                 760                 765             





Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 

    770                 775                 780                 





Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 

785                 790                 795                 800 





Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 

                805                 810                 815     





Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 

            820                 825                 830         





Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Arg Trp Asp 

        835                 840                 845             





Leu Ala Val Leu Ser Trp Leu Val Ser Asn Ser 

    850                 855                 





<210>  19

<211>  5843

<212>  DNA

<213>  Homo sapiens



<400>  19

gagcggacag gcgtggcggc cggagcccca gcatccctgc ttgaggtcca ggagcggagc       60



ccgcggccac cgccgcctga tcagcgcgac cccggcccgc gcccgccccg cccggcaaga      120



tgctgcccgt gtaccaggag gtgaagccca acccgctgca ggacgcgaac ctctgctcac      180



gcgtgttctt ctggtggctc aatcccttgt ttaaaattgg ccataaacgg agattagagg      240



aagatgatat gtattcagtg ctgccagaag accgctcaca gcaccttgga gaggagttgc      300



aagggttctg ggataaagaa gttttaagag ctgagaatga cgcacagaag ccttctttaa      360



caagagcaat cataaagtgt tactggaaat cttatttagt tttgggaatt tttacgttaa      420



ttgaggaaag tgccaaagta atccagccca tatttttggg aaaaattatt aattattttg      480



aaaattatga tcccatggat tctgtggctt tgaacacagc gtacgcctat gccacggtgc      540



tgactttttg cacgctcatt ttggctatac tgcatcactt atatttttat cacgttcagt      600



gtgctgggat gaggttacga gtagccatgt gccatatgat ttatcggaag gcacttcgtc      660



ttagtaacat ggccatgggg aagacaacca caggccagat agtcaatctg ctgtccaatg      720



atgtgaacaa gtttgatcag gtgacagtgt tcttacactt cctgtgggca ggaccactgc      780



aggcgattgc agtgactgcc ctactctgga tggagatagg aatatcgtgc cttgctggga      840



tggcagttct aatcattctc ctgcccttgc aaagctgttt tgggaagttg ttctcatcac      900



tgaggagtaa aactgcaact ttcacggatg ccaggatcag gaccatgaat gaagttataa      960



ctggtataag gataataaaa atgtacgcct gggaaaagtc attttcaaat cttattacca     1020



atttgagaaa gaaggagatt tccaagattc tgagaagttc ctgcctcaga gggatgaatt     1080



tggcttcatt tttcagtgca agcaaaatca tcgtgtttgt gaccttcacc acctacgtgc     1140



tcctcggcag tgtgatcaca gccagccgcg tgttcgtggc agtgacgctg tatggggctg     1200



tgcggctgac ggttaccctc ttcttcccct cagccattga gagggtgtca gaggcaatcg     1260



tcagcatccg aagaatccag acctttttgc tacttgatga gatatcacag cgcaaccgtc     1320



agctgccgtc agatggtaaa aagatggtgc atgtgcagga ttttactgct ttttgggata     1380



aggcatcaga gaccccaact ctacaaggcc tttcctttac tgtcagacct ggcgaattgt     1440



tagctgtggt cggccccgtg ggagcaggga agtcatcact gttaagtgcc gtgctcgggg     1500



aattggcccc aagtcacggg ctggtcagcg tgcatggaag aattgcctat gtgtctcagc     1560



agccctgggt gttctcggga actctgagga gtaatatttt atttgggaag aaatacgaaa     1620



aggaacgata tgaaaaagtc ataaaggctt gtgctctgaa aaaggattta cagctgttgg     1680



aggatggtga tctgactgtg ataggagatc ggggaaccac gctgagtgga gggcagaaag     1740



cacgggtaaa ccttgcaaga gcagtgtatc aagatgctga catctatctc ctggacgatc     1800



ctctcagtgc agtagatgcg gaagttagca gacacttgtt cgaactgtgt atttgtcaaa     1860



ttttgcatga gaagatcaca attttagtga ctcatcagtt gcagtacctc aaagctgcaa     1920



gtcagattct gatattgaaa gatggtaaaa tggtgcagaa ggggacttac actgagttcc     1980



taaaatctgg tatagatttt ggctcccttt taaagaagga taatgaggaa agtgaacaac     2040



ctccagttcc aggaactccc acactaagga atcgtacctt ctcagagtct tcggtttggt     2100



ctcaacaatc ttctagaccc tccttgaaag atggtgctct ggagagccaa gatacagaga     2160



atgtcccagt tacactatca gaggagaacc gttctgaagg aaaagttggt tttcaggcct     2220



ataagaatta cttcagagct ggtgctcact ggattgtctt cattttcctt attctcctaa     2280



acactgcagc tcaggttgcc tatgtgcttc aagattggtg gctttcatac tgggcaaaca     2340



aacaaagtat gctaaatgtc actgtaaatg gaggaggaaa tgtaaccgag aagctagatc     2400



ttaactggta cttaggaatt tattcaggtt taactgtagc taccgttctt tttggcatag     2460



caagatctct attggtattc tacgtccttg ttaactcttc acaaactttg cacaacaaaa     2520



tgtttgagtc aattctgaaa gctccggtat tattctttga tagaaatcca ataggaagaa     2580



ttttaaatcg tttctccaaa gacattggac acttggatga tttgctgccg ctgacgtttt     2640



tagatttcat ccagacattg ctacaagtgg ttggtgtggt ctctgtggct gtggccgtga     2700



ttccttggat cgcaataccc ttggttcccc ttggaatcat tttcattttt cttcggcgat     2760



attttttgga aacgtcaaga gatgtgaagc gcctggaatc tacaactcgg agtccagtgt     2820



tttcccactt atcatcttct ctccaggggc tctggaccat ccgggcatac aaagcagaag     2880



agaggtgtca ggaactgttt gatgcacacc aggatttaca ttcagaggct tggttcttgt     2940



ttttgacaac gtcccgctgg tttgccgtcc gtctggatgc catctgtgcc atgtttgtca     3000



tcatcgttgc ctttgggtcc ctgattctgg caaaaactct ggatgccggg caggttggtt     3060



tggcactgtc ctatgccctc acgctcatgg ggatgtttca gtggtgtgtt cgacaaagtg     3120



ctgaagttga gaatatgatg atctcagtag aaagggtcat tgaatacaca gaccttgaaa     3180



aagaagcacc ttgggaatat cagaaacgcc caccaccagc ctggccccat gaaggagtga     3240



taatctttga caatgtgaac ttcatgtaca gtccaggtgg gcctctggta ctgaagcatc     3300



tgacagcact cattaaatca caagaaaagg ttggcattgt gggaagaacc ggagctggaa     3360



aaagttccct catctcagcc ctttttagat tgtcagaacc cgaaggtaaa atttggattg     3420



ataagatctt gacaactgaa attggacttc acgatttaag gaagaagatg tcaatcatac     3480



ctcaggaacc tgttttgttc actggaacaa tgaggaaaaa cctggatccc tttaatgagc     3540



acacggatga ggaactgtgg aatgccttac aagaggtaca acttaaagaa accattgaag     3600



atcttcctgg taaaatggat actgaattag cagaatcagg atccaatttt agtgttggac     3660



aaagacaact ggtgtgcctt gccagggcaa ttctcaggaa aaatcagata ttgattattg     3720



atgaagcgac ggcaaatgtg gatccaagaa ctgatgagtt aatacaaaaa aaaatccggg     3780



agaaatttgc ccactgcacc gtgctaacca ttgcacacag attgaacacc attattgaca     3840



gcgacaagat aatggtttta gattcaggaa gactgaaaga atatgatgag ccgtatgttt     3900



tgctgcaaaa taaagagagc ctattttaca agatggtgca acaactgggc aaggcagaag     3960



ccgctgccct cactgaaaca gcaaaacagg tatacttcaa aagaaattat ccacatattg     4020



gtcacactga ccacatggtt acaaacactt ccaatggaca gccctcgacc ttaactattt     4080



tcgagacagc actgtgaatc caaccaaaat gtcaagtccg ttccgaaggc attttccact     4140



agtttttgga ctatgtaaac cacattgtac ttttttttac tttggcaaca aatatttata     4200



catacaagat gctagttcat ttgaatattt ctcccaactt atccaaggat ctccagctct     4260



aacaaaatgg tttattttta tttaaatgtc aatagttgtt ttttaaaatc caaatcagag     4320



gtgcaggcca ccagttaaat gccgtctatc aggttttgtg ccttaagaga ctacagagtc     4380



aaagctcatt tttaaaggag taggacaaag ttgtcacagg tttttgttgt tgtttttatt     4440



gcccccaaaa ttacatgtta atttccattt atatcaggga ttctatttac ttgaagactg     4500



tgaagttgcc attttgtctc attgttttct ttgacataac taggatccat tatttcccct     4560



gaaggcttct tgttagaaaa tagtacagtt acaaccaata ggaacaacaa aaagaaaaag     4620



tttgtgacat tgtagtaggg agtgtgtacc ccttactccc catcaaaaaa aaaaatggat     4680



acatggttaa aggatagaag ggcaatattt tatcatatgt tctaaaagag aaggaagaga     4740



aaatactact ttctcaaaat ggaagccctt aaaggtgctt tgatactgaa ggacacaaat     4800



gtgaccgtcc atcctccttt agagttgcat gacttggaca cggtaactgt tgcagtttta     4860



gactcagcat tgtgacactt cccaagaagg ccaaacctct aaccgacatt cctgaaatac     4920



gtggcattat tcttttttgg atttctcatt tatggaaggc taaccctctg ttgactgtaa     4980



gccttttggt ttgggctgta ttgaaatcct ttctaaattg catgaatagg ctctgctaac     5040



gtgatgagac aaactgaaaa ttattgcaag cattgactat aattatgcag tacgttctca     5100



ggatgcatcc aggggttcat tttcatgagc ctgtccaggt tagtttactc ctgaccacta     5160



atagcattgt catttgggct ttctgttgaa tgaatcaaca aaccacaata cttcctggga     5220



ccttttgtac tttatttgaa ctatgagtct ttaatttttc ctgatgatgg tggctgtaat     5280



atgttgagtt cagtttacta aaggttttac tattatggtt tgaagtggag tctcatgacc     5340



tctcagaata aggtgtcacc tccctgaaat tgcatatatg tatatagaca tgcacacgtg     5400



tgcatttgtt tgtatacata tatttgtcct tcgtatagca agttttttgc tcatcagcag     5460



agagcaacag atgttttatt gagtgaagcc ttaaaaagca cacaccacac acagctaact     5520



gccaaaatac attgaccgta gtagctgttc aactcctagt acttagaaat acacgtatgg     5580



ttaatgttca gtccaacaaa ccacacacag taaatgttta ttaatagtca tggttcgtat     5640



tttaggtgac tgaaattgca tcagtgatca taatgaggtt tgttaaaacg atagctatat     5700



tcaaaatgtc tatatgttta tttggacttt tgaggttaaa gacagtcata taaacgtcct     5760



gtttctgttt taatgttatc atagaatttt ttaatgaaac taaattcaat tgaaataaat     5820



gatagttttc atctccattc aga                                             5843





<210>  20

<211>  1325

<212>  PRT

<213>  Homo sapiens



<400>  20



Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 

1               5                   10                  15      





Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 

            20                  25                  30          





Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 

        35                  40                  45              





Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 

    50                  55                  60                  





Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 

65                  70                  75                  80  





Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 

                85                  90                  95      





Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 

            100                 105                 110         





Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 

        115                 120                 125             





Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 

    130                 135                 140                 





Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 

145                 150                 155                 160 





Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 

                165                 170                 175     





Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 

            180                 185                 190         





Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 

        195                 200                 205             





Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 

    210                 215                 220                 





Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 

225                 230                 235                 240 





Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 

                245                 250                 255     





Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 

            260                 265                 270         





Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 

        275                 280                 285             





Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 

    290                 295                 300                 





Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 

305                 310                 315                 320 





Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 

                325                 330                 335     





Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 

            340                 345                 350         





Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 

        355                 360                 365             





Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 

    370                 375                 380                 





Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 

385                 390                 395                 400 





Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 

                405                 410                 415     





Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 

            420                 425                 430         





Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 

        435                 440                 445             





Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 

    450                 455                 460                 





Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 

465                 470                 475                 480 





Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 

                485                 490                 495     





Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 

            500                 505                 510         





Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 

        515                 520                 525             





Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 

    530                 535                 540                 





Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 

545                 550                 555                 560 





Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 

                565                 570                 575     





Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 

            580                 585                 590         





Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 

        595                 600                 605             





Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 

    610                 615                 620                 





Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 

625                 630                 635                 640 





Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 

                645                 650                 655     





Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 

            660                 665                 670         





Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 

        675                 680                 685             





Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 

    690                 695                 700                 





Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 

705                 710                 715                 720 





Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 

                725                 730                 735     





Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 

            740                 745                 750         





Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 

        755                 760                 765             





Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 

    770                 775                 780                 





Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 

785                 790                 795                 800 





Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 

                805                 810                 815     





Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 

            820                 825                 830         





Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Thr Leu Leu 

        835                 840                 845             





Gln Val Val Gly Val Val Ser Val Ala Val Ala Val Ile Pro Trp Ile 

    850                 855                 860                 





Ala Ile Pro Leu Val Pro Leu Gly Ile Ile Phe Ile Phe Leu Arg Arg 

865                 870                 875                 880 





Tyr Phe Leu Glu Thr Ser Arg Asp Val Lys Arg Leu Glu Ser Thr Thr 

                885                 890                 895     





Arg Ser Pro Val Phe Ser His Leu Ser Ser Ser Leu Gln Gly Leu Trp 

            900                 905                 910         





Thr Ile Arg Ala Tyr Lys Ala Glu Glu Arg Cys Gln Glu Leu Phe Asp 

        915                 920                 925             





Ala His Gln Asp Leu His Ser Glu Ala Trp Phe Leu Phe Leu Thr Thr 

    930                 935                 940                 





Ser Arg Trp Phe Ala Val Arg Leu Asp Ala Ile Cys Ala Met Phe Val 

945                 950                 955                 960 





Ile Ile Val Ala Phe Gly Ser Leu Ile Leu Ala Lys Thr Leu Asp Ala 

                965                 970                 975     





Gly Gln Val Gly Leu Ala Leu Ser Tyr Ala Leu Thr Leu Met Gly Met 

            980                 985                 990         





Phe Gln Trp Cys Val Arg Gln Ser  Ala Glu Val Glu Asn  Met Met Ile 

        995                 1000                 1005             





Ser Val  Glu Arg Val Ile Glu  Tyr Thr Asp Leu Glu  Lys Glu Ala 

    1010                 1015                 1020             





Pro Trp  Glu Tyr Gln Lys Arg  Pro Pro Pro Ala Trp  Pro His Glu 

    1025                 1030                 1035             





Gly Val  Ile Ile Phe Asp Asn  Val Asn Phe Met Tyr  Ser Pro Gly 

    1040                 1045                 1050             





Gly Pro  Leu Val Leu Lys His  Leu Thr Ala Leu Ile  Lys Ser Gln 

    1055                 1060                 1065             





Glu Lys  Val Gly Ile Val Gly  Arg Thr Gly Ala Gly  Lys Ser Ser 

    1070                 1075                 1080             





Leu Ile  Ser Ala Leu Phe Arg  Leu Ser Glu Pro Glu  Gly Lys Ile 

    1085                 1090                 1095             





Trp Ile  Asp Lys Ile Leu Thr  Thr Glu Ile Gly Leu  His Asp Leu 

    1100                 1105                 1110             





Arg Lys  Lys Met Ser Ile Ile  Pro Gln Glu Pro Val  Leu Phe Thr 

    1115                 1120                 1125             





Gly Thr  Met Arg Lys Asn Leu  Asp Pro Phe Asn Glu  His Thr Asp 

    1130                 1135                 1140             





Glu Glu  Leu Trp Asn Ala Leu  Gln Glu Val Gln Leu  Lys Glu Thr 

    1145                 1150                 1155             





Ile Glu  Asp Leu Pro Gly Lys  Met Asp Thr Glu Leu  Ala Glu Ser 

    1160                 1165                 1170             





Gly Ser  Asn Phe Ser Val Gly  Gln Arg Gln Leu Val  Cys Leu Ala 

    1175                 1180                 1185             





Arg Ala  Ile Leu Arg Lys Asn  Gln Ile Leu Ile Ile  Asp Glu Ala 

    1190                 1195                 1200             





Thr Ala  Asn Val Asp Pro Arg  Thr Asp Glu Leu Ile  Gln Lys Lys 

    1205                 1210                 1215             





Ile Arg  Glu Lys Phe Ala His  Cys Thr Val Leu Thr  Ile Ala His 

    1220                 1225                 1230             





Arg Leu  Asn Thr Ile Ile Asp  Ser Asp Lys Ile Met  Val Leu Asp 

    1235                 1240                 1245             





Ser Gly  Arg Leu Lys Glu Tyr  Asp Glu Pro Tyr Val  Leu Leu Gln 

    1250                 1255                 1260             





Asn Lys  Glu Ser Leu Phe Tyr  Lys Met Val Gln Gln  Leu Gly Lys 

    1265                 1270                 1275             





Ala Glu  Ala Ala Ala Leu Thr  Glu Thr Ala Lys Gln  Val Tyr Phe 

    1280                 1285                 1290             





Lys Arg  Asn Tyr Pro His Ile  Gly His Thr Asp His  Met Val Thr 

    1295                 1300                 1305             





Asn Thr  Ser Asn Gly Gln Pro  Ser Thr Leu Thr Ile  Phe Glu Thr 

    1310                 1315                 1320             





Ala Leu  

    1325 





<210>  21

<211>  4209

<212>  DNA

<213>  Homo sapiens



<400>  21

ccgccgcgga gcgaggttgc ctggagagag cgcctgggcg cagaagggtt aacgggccac       60



cgggggctcg cagagcagga gggtgctctc ggacggtgtg tcccccactg cactcctgaa      120



cttggaggac agggtcgccg cgagggacgc agagagcacc ctccacgccc agatgcctgc      180



gtagtttttg tgaccagtcc gctcctgcct ccccctgggg cagtagaggg ggagcgatgg      240



agaactggac tggcaggccc tggctgtatc tgctgctgct tctgtccctc cctcagctct      300



gcttggatca ggaggtgttg tccggacact ctcttcagac acctacagag gagggccagg      360



gccccgaagg tgtctgggga ccttgggtcc agtgggcctc ttgctcccag ccctgcgggg      420



tgggggtgca gcgcaggagc cggacatgtc agctccctac agtgcagctc cacccgagtc      480



tgcccctccc tccccggccc ccaagacatc cagaagccct cctcccccgg ggccagggtc      540



ccagacccca gacttctcca gaaaccctcc ccttgtacag gacacagtct cggggaaggg      600



gtggcccact tcgaggtccc gcttcccacc tagggagaga ggagacccag gagattcgag      660



cggccaggag gtcccggctt cgagacccca tcaagccagg aatgttcggt tatgggagag      720



tgccctttgc attgccactg caccggaacc gcaggcaccc tcggagccca cccagatctg      780



agctgtccct gatctcttct agaggggaag aggctattcc gtcccctact ccaagagcag      840



agccattctc cgcaaacggc agcccccaaa ctgagctccc tcccacagaa ctgtctgtcc      900



acaccccatc cccccaagca gaacctctaa gccctgaaac tgctcagaca gaggtggccc      960



ccagaaccag gcctgccccc ctacggcatc accccagagc ccaggcctct ggcacagagc     1020



ccccctcacc cacgcactcc ttaggagaag gtggcttctt ccgtgcatcc cctcagccac     1080



gaaggccaag ttcccagggt tgggccagtc cccaggtagc agggagacgc cctgatcctt     1140



ttccttcggt ccctcggggc cgaggccagc agggccaagg gccttgggga acggggggga     1200



ctcctcacgg gccccgcctg gagcctgacc ctcagcaccc gggcgcctgg ctgcccctgc     1260



tgagcaacgg cccccatgcc agctccctct ggagcctctt tgctcccagt agccctattc     1320



caagatgttc tggggagagt gaacagctaa gagcctgcag ccaagcgccc tgcccccctg     1380



agcagccaga cccccgggcc ctgcagtgcg cagcctttaa ctcccaggaa ttcatgggcc     1440



agctgtatca gtgggagccc ttcactgaag tccagggctc ccagcgctgt gaactgaact     1500



gccggccccg tggcttccgc ttctatgtcc gtcacactga aaaggtccag gatgggaccc     1560



tgtgtcagcc tggagcccct gacatctgtg tggctggacg ctgtctgagc cccggctgtg     1620



atgggatcct tggctctggc aggcgtcctg atggctgtgg agtctgtggg ggtgatgatt     1680



ctacctgtcg ccttgtttcg gggaacctca ctgaccgagg gggccccctg ggctatcaga     1740



agatcttgtg gattccagcg ggagccttgc ggctccagat tgcccagctc cggcctagct     1800



ccaactacct ggcacttcgt ggccctgggg gccggtccat catcaatggg aactgggctg     1860



tggatccccc tgggtcctac agggccggcg ggaccgtctt tcgatataac cgtcctccca     1920



gggaggaggg caaaggggag agtctgtcgg ctgaaggccc caccacccag cctgtggatg     1980



tctatatgat ctttcaggag gaaaacccag gcgtttttta tcagtatgtc atctcttcac     2040



ctcctccaat ccttgagaac cccaccccag agccccctgt cccccagctt cagccggaga     2100



ttctgagggt ggagccccca cttgctccgg caccccgccc agcccggacc ccaggcaccc     2160



tccagcgtca ggtgcggatc ccccagatgc ccgccccgcc ccatcccagg acacccctgg     2220



ggtctccagc tgcgtactgg aaacgagtgg gacactctgc atgctcagcg tcctgcggga     2280



aaggtgtctg gcgccccatt ttcctctgca tctcccgtga gtcgggagag gaactggatg     2340



aacgcagctg tgccgcgggt gccaggcccc cagcctcccc tgaaccctgc cacggcaccc     2400



catgcccccc atactgggag gctggcgagt ggacatcctg cagccgctcc tgtggccccg     2460



gcacccagca ccgccagctg cagtgccggc aggaatttgg ggggggtggc tcctcggtgc     2520



ccccggagcg ctgtggacat ctcccccggc ccaacatcac ccagtcttgc cagctgcgcc     2580



tctgtggcca ttgggaagtt ggctctcctt ggagccagtg ctccgtgcgg tgcggccggg     2640



gccagagaag ccggcaggtt cgctgtgttg ggaacaatgg tgatgaagtg agcgagcagg     2700



agtgtgcgtc aggccccccg cagcccccca gcagagaggc ctgtgacatg gggccctgta     2760



ctactgcctg gttccacagc gactggagct ccaagtgctc agccgagtgt gggacgggaa     2820



tccagcggcg ctctgtggtc tgccttggga gtggggcagc cctcgggcca ggccaggggg     2880



aagcaggagc aggaactggg cagagctgtc caacaggaag ccggccccct gacatgcgcg     2940



cctgcagcct ggggccctgt gagagaactt ggcgctggta cacagggccc tggggtgagt     3000



gctcctccga atgtggctct ggcacacagc gtagagacat catctgtgta tccaaactgg     3060



ggacggagtt caacgtgact tctccgagca actgttctca cctccccagg ccccctgccc     3120



tgcagccctg tcaagggcag gcctgccagg accgatggtt ttccacgccc tggagcccat     3180



gttctcgctc ctgccaaggg ggaacgcaga cacgggaggt ccagtgcctg agcaccaacc     3240



agaccctcag cacccgatgc cctcctcaac tgcggccctc caggaagcgc ccctgtaaca     3300



gccaaccctg cagccagcgc cctgatgatc aatgcaagga cagctctcca cattgccccc     3360



tggtggtaca ggcccggctc tgcgtctacc cctactacac agccacctgt tgccgctctt     3420



gcgcacatgt cctggagcgg tctccccagg atccctcctg aaaggggtcc ggggcacctt     3480



cacggttttc tgtgccacca tcggtcaccc attgatcggc ccactctgaa ccccctggct     3540



ctccagcctg tcccagtctc agcagggatg tcctccaggt gacagagggt ggcaaggtga     3600



ctgacacaaa gtgactttca gggctgtggt caggcccatg tggtggtgtg atgggtgtgt     3660



gcacatatgc ctcaggtgtg cttttgggac tgcatggata tgtgtgtgct caaacgtgta     3720



tcacttttca aaaagaggtt acacagactg agaaggacaa gacctgtttc cttgagactt     3780



tcctaggtgg aaaggaaagc aagtctgcag ttccttgcta atctgagcta cttagagtgt     3840



ggtctcccca ccaactccag ttttgtgccc taagcctcat ttctcatgtt cagacctcac     3900



atcttctaag ccgccctgtg tctctgaccc cttctcattt gcctagtatc tctgcccctg     3960



cctccctaat tagctagggc tggggtcagc cactgccaat cctgccttac tcaggaaggc     4020



aggaggaaag agactgcctc tccagagcaa ggcccagctg ggcagagggt gaaaaagaga     4080



aatgtgagca tccgctcccc caccaccccg cccagcccct agccccactc cctgcctcct     4140



gaaatggttc ccacccagaa ctaatttatt ttttattaaa gatggtcatg acaaatgaga     4200



aaaaaaaaa                                                             4209





<210>  22

<211>  1074

<212>  PRT

<213>  Homo sapiens



<400>  22



Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 

1               5                   10                  15      





Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 

            20                  25                  30          





Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 

        35                  40                  45              





Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 

    50                  55                  60                  





Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 

65                  70                  75                  80  





Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 

                85                  90                  95      





Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 

            100                 105                 110         





Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 

        115                 120                 125             





Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 

    130                 135                 140                 





Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 

145                 150                 155                 160 





Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 

                165                 170                 175     





Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 

            180                 185                 190         





Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 

        195                 200                 205             





Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 

    210                 215                 220                 





Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 

225                 230                 235                 240 





Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 

                245                 250                 255     





Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 

            260                 265                 270         





Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 

        275                 280                 285             





Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 

    290                 295                 300                 





Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 

305                 310                 315                 320 





Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 

                325                 330                 335     





Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 

            340                 345                 350         





Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 

        355                 360                 365             





Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 

    370                 375                 380                 





Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 

385                 390                 395                 400 





Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 

                405                 410                 415     





Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 

            420                 425                 430         





His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 

        435                 440                 445             





Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 

    450                 455                 460                 





Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 

465                 470                 475                 480 





Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 

                485                 490                 495     





Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 

            500                 505                 510         





Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 

        515                 520                 525             





Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 

    530                 535                 540                 





Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 

545                 550                 555                 560 





Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 

                565                 570                 575     





Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 

            580                 585                 590         





Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 

        595                 600                 605             





Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 

    610                 615                 620                 





Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 

625                 630                 635                 640 





Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 

                645                 650                 655     





Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 

            660                 665                 670         





His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 

        675                 680                 685             





Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 

    690                 695                 700                 





Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 

705                 710                 715                 720 





Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 

                725                 730                 735     





Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 

            740                 745                 750         





Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 

        755                 760                 765             





Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 

    770                 775                 780                 





His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 

785                 790                 795                 800 





Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 

                805                 810                 815     





Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 

            820                 825                 830         





Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 

        835                 840                 845             





Asp Trp Ser Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg 

    850                 855                 860                 





Arg Ser Val Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln 

865                 870                 875                 880 





Gly Glu Ala Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg 

                885                 890                 895     





Pro Pro Asp Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp 

            900                 905                 910         





Arg Trp Tyr Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser 

        915                 920                 925             





Gly Thr Gln Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu 

    930                 935                 940                 





Phe Asn Val Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro 

945                 950                 955                 960 





Ala Leu Gln Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser 

                965                 970                 975     





Thr Pro Trp Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr 

            980                 985                 990         





Arg Glu Val Gln Cys Leu Ser Thr  Asn Gln Thr Leu Ser  Thr Arg Cys 

        995                 1000                 1005             





Pro Pro  Gln Leu Arg Pro Ser  Arg Lys Arg Pro Cys  Asn Ser Gln 

    1010                 1015                 1020             





Pro Cys  Ser Gln Arg Pro Asp  Asp Gln Cys Lys Asp  Ser Ser Pro 

    1025                 1030                 1035             





His Cys  Pro Leu Val Val Gln  Ala Arg Leu Cys Val  Tyr Pro Tyr 

    1040                 1045                 1050             





Tyr Thr  Ala Thr Cys Cys Arg  Ser Cys Ala His Val  Leu Glu Arg 

    1055                 1060                 1065             





Ser Pro  Gln Asp Pro Ser 

    1070                 





<210>  23

<211>  2897

<212>  DNA

<213>  Homo sapiens



<400>  23

ccgccgcgga gcgaggttgc ctggagagag cgcctgggcg cagaagggtt aacgggccac       60



cgggggctcg cagagcagga gggtgctctc ggacggtgtg tcccccactg cactcctgaa      120



cttggaggac agggtcgccg cgagggacgc agagagcacc ctccacgccc agatgcctgc      180



gtagtttttg tgaccagtcc gctcctgcct ccccctgggg cagtagaggg ggagcgatgg      240



agaactggac tggcaggccc tggctgtatc tgctgctgct tctgtccctc cctcagctct      300



gcttggatca ggaggtgttg tccggacact ctcttcagac acctacagag gagggccagg      360



gccccgaagg tgtctgggga ccttgggtcc agtgggcctc ttgctcccag ccctgcgggg      420



tgggggtgca gcgcaggagc cggacatgtc agctccctac agtgcagctc cacccgagtc      480



tgcccctccc tccccggccc ccaagacatc cagaagccct cctcccccgg ggccagggtc      540



ccagacccca gacttctcca gaaaccctcc ccttgtacag gacacagtct cggggaaggg      600



gtggcccact tcgaggtccc gcttcccacc tagggagaga ggagacccag gagattcgag      660



cggccaggag gtcccggctt cgagacccca tcaagccagg aatgttcggt tatgggagag      720



tgccctttgc attgccactg caccggaacc gcaggcaccc tcggagccca cccagatctg      780



agctgtccct gatctcttct agaggggaag aggctattcc gtcccctact ccaagagcag      840



agccattctc cgcaaacggc agcccccaaa ctgagctccc tcccacagaa ctgtctgtcc      900



acaccccatc cccccaagca gaacctctaa gccctgaaac tgctcagaca gaggtggccc      960



ccagaaccag gcctgccccc ctacggcatc accccagagc ccaggcctct ggcacagagc     1020



ccccctcacc cacgcactcc ttaggagaag gtggcttctt ccgtgcatcc cctcagccac     1080



gaaggccaag ttcccagggt tgggccagtc cccaggtagc agggagacgc cctgatcctt     1140



ttccttcggt ccctcggggc cgaggccagc agggccaagg gccttgggga acggggggga     1200



ctcctcacgg gccccgcctg gagcctgacc ctcagcaccc gggcgcctgg ctgcccctgc     1260



tgagcaacgg cccccatgcc agctccctct ggagcctctt tgctcccagt agccctattc     1320



caagatgttc tggggagagt gaacagctaa gagcctgcag ccaagcgccc tgcccccctg     1380



agcagccaga cccccgggcc ctgcagtgcg cagcctttaa ctcccaggaa ttcatgggcc     1440



agctgtatca gtgggagccc ttcactgaag tccagggctc ccagcgctgt gaactgaact     1500



gccggccccg tggcttccgc ttctatgtcc gtcacactga aaaggtccag gatgggaccc     1560



tgtgtcagcc tggagcccct gacatctgtg tggctggacg ctgtctgagc cccggctgtg     1620



atgggatcct tggctctggc aggcgtcctg atggctgtgg agtctgtggg ggtgatgatt     1680



ctacctgtcg ccttgtttcg gggaacctca ctgaccgagg gggccccctg ggctatcaga     1740



agatcttgtg gattccagcg ggagccttgc ggctccagat tgcccagctc cggcctagct     1800



ccaactacct ggcacttcgt ggccctgggg gccggtccat catcaatggg aactgggctg     1860



tggatccccc tgggtcctac agggccggcg ggaccgtctt tcgatataac cgtcctccca     1920



gggaggaggg caaaggggag agtctgtcgg ctgaaggccc caccacccag cctgtggatg     1980



tctatatgat ctttcaggag gaaaacccag gcgtttttta tcagtatgtc atctcttcac     2040



ctcctccaat ccttgagaac cccaccccag agccccctgt cccccagctt cagccggaga     2100



ttctgagggt ggagccccca cttgctccgg caccccgccc agcccggacc ccaggcaccc     2160



tccagcgtca ggtgcggatc ccccagatgc ccgccccgcc ccatcccagg acacccctgg     2220



ggtctccagc tgcgtactgg aaacgagtgg gacactctgc atgctcagcg tcctgcggga     2280



aaggtgtctg gcgccccatt ttcctctgca tctcccgtga gtcgggagag gaactggatg     2340



aacgcagctg tgccgcgggt gccaggcccc cagcctcccc tgaaccctgc cacggcaccc     2400



catgcccccc atactgggag gctggcgagt ggacatcctg cagccgctcc tgtggccccg     2460



gcacccagca ccgccagctg cagtgccggc aggaatttgg ggggggtggc tcctcggtgc     2520



ccccggagcg ctgtggacat ctcccccggc ccaacatcac ccagtcttgc cagctgcgcc     2580



tctgtggcca ttgggaagtt ggctctcctt ggagccagtg ctccgtgcgg tgcggccggg     2640



gccagagaag ccggcaggtt cgctgtgttg ggaacaatgg tgatgaagtg agcgagcagg     2700



agtgtgcgtc aggccccccg cagcccccca gcagagaggc ctgtgacatg gggccctgta     2760



ctactgcctg gttccacagc gactggagct ccaaggtgag cccggaaccc ccagccatat     2820



cctgcatcct gggtaaccac gcccaggaca cctcagcctt tccagcatag ctcaataaac     2880



ttgtattgat caaaaaa                                                    2897





<210>  24

<211>  877

<212>  PRT

<213>  Homo sapiens



<400>  24



Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 

1               5                   10                  15      





Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 

            20                  25                  30          





Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 

        35                  40                  45              





Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 

    50                  55                  60                  





Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 

65                  70                  75                  80  





Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 

                85                  90                  95      





Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 

            100                 105                 110         





Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 

        115                 120                 125             





Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 

    130                 135                 140                 





Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 

145                 150                 155                 160 





Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 

                165                 170                 175     





Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 

            180                 185                 190         





Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 

        195                 200                 205             





Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 

    210                 215                 220                 





Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 

225                 230                 235                 240 





Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 

                245                 250                 255     





Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 

            260                 265                 270         





Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 

        275                 280                 285             





Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 

    290                 295                 300                 





Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 

305                 310                 315                 320 





Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 

                325                 330                 335     





Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 

            340                 345                 350         





Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 

        355                 360                 365             





Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 

    370                 375                 380                 





Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 

385                 390                 395                 400 





Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 

                405                 410                 415     





Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 

            420                 425                 430         





His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 

        435                 440                 445             





Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 

    450                 455                 460                 





Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 

465                 470                 475                 480 





Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 

                485                 490                 495     





Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 

            500                 505                 510         





Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 

        515                 520                 525             





Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 

    530                 535                 540                 





Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 

545                 550                 555                 560 





Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 

                565                 570                 575     





Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 

            580                 585                 590         





Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 

        595                 600                 605             





Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 

    610                 615                 620                 





Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 

625                 630                 635                 640 





Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 

                645                 650                 655     





Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 

            660                 665                 670         





His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 

        675                 680                 685             





Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 

    690                 695                 700                 





Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 

705                 710                 715                 720 





Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 

                725                 730                 735     





Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 

            740                 745                 750         





Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 

        755                 760                 765             





Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 

    770                 775                 780                 





His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 

785                 790                 795                 800 





Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 

                805                 810                 815     





Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 

            820                 825                 830         





Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 

        835                 840                 845             





Asp Trp Ser Ser Lys Val Ser Pro Glu Pro Pro Ala Ile Ser Cys Ile 

    850                 855                 860                 





Leu Gly Asn His Ala Gln Asp Thr Ser Ala Phe Pro Ala 

865                 870                 875         





<210>  25

<211>  9121

<212>  DNA

<213>  Homo sapiens



<400>  25

gcgcaactga cggtcgcgtt ctgcgcgcga gctagttgcc tcccgtacct gccgcggtcg       60



ccggccccgc ccccgggagc gcgggccaat gggctgggct ccagggggcg gggctggcgg      120



gcgggcggtg cggccgtggc ggtagctgca ggggcggtgg cggctgcagt ggtggtggtg      180



cctgtggctg tggctgcggc tgcggctgcg gctgagattt ggccgggcgt ccgcaggccg      240



tgggggatgg gggcagcgag ctccagccct cggcggtggc ggcggccgta ggtgtggggc      300



gggcgtccgc gtccggcacg cgagatggag cgccgtggat ttcagttttt ctgactgtta      360



catgaaagga tgattgctca caaacagaaa aagacaaaga aaaaacgtgc ttgggcatca      420



ggtcaactct ctactgatat tacaacttct gaaatggggc tcaagtcctt aagttccaac      480



tctatttttg atccggatta catcaaggag ttggtgaatg atatcaggaa gttctcccac      540



atgttactat atttgaaaga agccatattt tcagactgtt ttaaagaagt tattcatata      600



cgtctagagg aactgctccg tgttttaaag tctataatga ataaacatca gaacctcaat      660



tctgttgatc ttcaaaatgc tgcagaaatg ctcactgcaa aagtgaaagc tgtgaacttc      720



acagaagtta atgaagaaaa caaaaacgat ctcttccagg aagtgttttc ttctattgaa      780



actttggcat ttacctttgg aaatatcctt acaaacttcc ttatgggaga tgtaggcaat      840



gattcattat tgcgactgcc tgtttctcga gaaactaagt cgtttgaaaa tgtttctgtg      900



gaatcagtgg actcatccag tgaaaaagga aatttttccc ctttagaact agacaacgtg      960



ctgttaaaga acactgactc tatcgagctg gctttgtcat atgctaaaac ttggtcaaaa     1020



tatactaaga acatagtttc atgggttgaa aaaaagctta acttggaatt ggagtccact     1080



agaaatatgg tcaagttggc agaggcaact agaactaaca ttggaattca ggagttcatg     1140



ccactgcagt ctctgtttac taatgctctt cttaatgata tagaaagcag tcacctttta     1200



caacaaacaa ttgcagctct ccaggctaac aaatttgtgc agcctctact tggaaggaaa     1260



aatgaaatgg aaaaacaaag gaaagaaata aaagagcttt ggaaacagga gcaaaataaa     1320



atgcttgaag cagagaatgc tctcaaaaag gcaaaattat tatgcatgca acgtcaagat     1380



gaatatgaga aagcaaagtc ttccatgttt cgtgcagaag aggagcatct gtcttcaagt     1440



ggcggattag caaaaaatct caacaagcaa ctagaaaaaa agcgaaggtt ggaagaggag     1500



gctctccaaa aagtagaaga agcaaatgaa ctttacaaag tttgtgtgac aaatgttgaa     1560



gaaagaagaa atgatctaga aaataccaaa agagaaattt tagcacaact ccggacactt     1620



gttttccagt gtgatcttac ccttaaagct gtaacagtta acctcttcca catgcagcat     1680



ctgcaggctg cttcccttgc agacagttta cagtctctct gtgatagtgc caaactctat     1740



gacccaggcc aagagtacag tgaatttgtc aaggccacaa attcaactga agaagaaaaa     1800



gttgatggaa atgtaaataa acatttaaat agttcccaac cttcaggatt tggacctgcc     1860



aactctttag aggatgttgt acgccttcct gacagttcta ataaaattga agaggacaga     1920



tgctctaaca gtgcagatat aacaggtcct tcctttataa gatcatggac atttgggatg     1980



tttagtgatt ctgagagcac tggagggagc agcgaatcta gatctctgga ttcagaatct     2040



ataagtccag gagactttca tcgaaaactt ccacgaacac catccagtgg aactatgtcc     2100



tctgcagatg atctagatga aagagagcca ccttcccctt cagaaactgg acccaattcc     2160



cttggaacat ttaagaaaac attgatgtca aaggcagctc tcacacacaa gtttcgcaaa     2220



ttgagatccc ccacgaaatg tagggattgt gaaggcattg tagtgttcca aggtgttgaa     2280



tgtgaagagt gtctccttgt ttgtcatcga aagtgtttgg aaaatttagt cattatttgt     2340



ggtcatcaga aacttccagg aaaaatacac ttatttggag cagaattcac acaagttgca     2400



aaaaaggaac cagatggtat cccttttata ctcaaaatat gtgcctcaga gattgaaaat     2460



agagctttgt gtctacaggg aatttatcgt gtgtgtggaa acaaaataaa aactgaaaaa     2520



ttgtgtcaag ctttggaaaa tggaatgcac ttggtagata tttcagaatt tagttcacat     2580



gatatctgtg acgtcttgaa attatacctt cggcagctcc cagaaccatt tattttattt     2640



cgattgtaca aggaatttat agaccttgca aaagagatcc aacatgtaaa tgaagaacaa     2700



gagacaaaaa agaatagtct tgaagacaaa aaatggccaa atatgtgtat agaaataaac     2760



cgaattcttc taaaaagcaa agaccttcta agacaattgc cagcatcaaa ttttaacagt     2820



cttcatttcc ttatagtaca tctaaagcgg gtagtagatc atgcagaaga aaacaagatg     2880



aactccaaaa acttgggggt gatatttgga ccaagtctca ttaggccaag gcccacaact     2940



gctcctatca ccatctcctc ccttgcagag tattcaaatc aagcacgctt ggtagagttt     3000



ctcattactt actcacagaa gatcttcgat gggtccctac aaccacaaga tgttatgtgt     3060



agcataggtg ttgttgatca aggctgtttt ccaaagcctc tgttatcacc agaagaaaga     3120



gacattgaac gttccatgaa gtcactattt ttttcttcaa aggaagatat ccatacttca     3180



gagagtgaaa gcaaaatttt tgaacgagct acatcatttg aggaatcaga acgcaagcaa     3240



aatgcgttag gaaaatgtga tgcatgtctc agtgacaaag cacagttgct tctagaccaa     3300



gaggctgaat cagcatccca aaagatagaa gatggtaaaa cccctaagcc actttctctg     3360



aaatctgata ggtcaacaaa caatgtggag aggcatactc caaggaccaa gattagacct     3420



gtaagtttgc ctgtagatag actacttctt gcaagtcctc ctaatgagag aaatggcaga     3480



aatatgggaa atgtaaattt agacaagttt tgcaagaatc ctgcctttga aggagttaat     3540



agaaaagacg ctgctactac tgtttgttcc aaatttaatg gctttgacca gcaaactcta     3600



cagaaaattc aggacaaaca gtatgaacaa aacagcctaa ctgccaagac tacaatgatc     3660



atgcccagtg cactccagga aaaaggagtg acaacaagcc tccagattag tggggaccat     3720



tctatcaatg ccactcaacc cagtaagcca tatgcagagc cagtcaggtc agtgagagag     3780



gcatctgaga gacggtcttc agattcctac cctctcgctc ctgtcagagc acccagaaca     3840



ctgcagcctc aacattggac aacattttat aaaccacatg ctcccatcat cagtatcagg     3900



gggaatgagg agaagccagc ttcaccctca gcagcagtgc ctcctggcac agatcacgat     3960



ccccacggtc tcgtggtgaa gtcaatgcca gacccagaca aagcatcagc ttgtcctggg     4020



caagcaactg gtcaacctaa agaagactct gaggagcttg gcttgcctga tgtgaatcca     4080



atgtgtcaga gaccaaggct aaaacgaatg caacagtttg aagacctcga aggtgaaatt     4140



ccacaatttg tgtagggatg tcaaatttca gggttttttt gttgttgttg tgttattttg     4200



tggtattgtg cttgttttgt gaaagaatgt tttgacaggg cctcttttgt ataggactgc     4260



caaatcatgg gttttgcctt ttgttgttgt atttatcctc tgttggtaat actgaatggt     4320



agaatgtttt gatagggtca catttgtgcc tcactggaat tatctttaaa ttctgtattt     4380



ttaaagttgt gaataagata ggtggattcg tattttttaa agttcagttg actttcccca     4440



ccaaatggtc catttgaatg catccctaat atatgatata gtctcaacta ataggtgcaa     4500



tttgggaaaa tcaggtttat tttttggagt ggaactgtta taagtgctta tttataaaag     4560



gaatgtttct gaatgcaagt gcctaaaaag atctttgttg gtatgcatat gttttgtcac     4620



acaattttat agtgcatctt tcaccatttg tgctttttta agatacgtat gtaagctctt     4680



atttttcaat tggcaattca gttaattttt aaatgtttac ataatggcca gaaggcttgc     4740



aaatctgtat ttaattgcat tttaattaat tgccagtttt tacatgtgat agtcagttgt     4800



acaaagaaaa tgcacttaaa cctgtttcta aattatatat tcagttatat tatatttggc     4860



tttagatggt tttaatacat ttgatagttt ttcacccctt ggctttattt tatataaact     4920



tttgtttttc agcagttctg aactttttag tattttataa atggtccaaa aaatgcctgt     4980



ttcagaagtt tttgaattca gtgcatttcc tcttgatttg tctgggttaa aaccattcct     5040



tttgtatgaa atgttttgac ttaggaatca ttttatgtac ttgttctacc tggattgtca     5100



acaactgaaa gtacatattt catccaaatc aagctaaaat ttatttaagt tgattctgag     5160



agtacaggtc agtaagcctc attatttgga atttgagaga aggtataggt gatcggatct     5220



gtttcattta taaaaggtcc agtttttagg actagtacat tcctgttatt ttctgggttt     5280



tatcattttg cctaaaatag gatataaaag ggacaaaaaa taagtagact gtttttatgt     5340



gtgaattata tttctactaa atgtttttgt atgactgtgt tatacttgat aatatatata     5400



tatatatata tcaacttgtt aaattatttc atgttcccgt ggcttctttt cagttgttgc     5460



ctattacagt atgagagttt aaggttatta accattggct tagaagtcaa cacctaggat     5520



catacatccg ttgactacaa tgtggaatga attttatgga aacctgtttt atagttctat     5580



gtgatgtaaa ggtctaggga gcaataacca gccctttttt ttctgaaggc ttgtttttag     5640



tcctcattgt acaaaatata aaataatcat attgctatga atacctaaaa agaaaattag     5700



agcccatgtg tattgagcct tctctgtgtg ccaggaactt tgccaaggtg ctacatagat     5760



tattttattt caagttcaca gcaacctata atgggtgggt aagcatgtta ttatttctgt     5820



gttacagata aggaaactaa ggcttagtta aatgacttgc ttcagtgttc cacaggtgta     5880



acaggtggag tcaaatctca aacatagggc tgtcagattt tgatggttag tgctcttaat     5940



gactgtgatt actaaataat atctggtagt ttttaacaat agaaaatgca actttaaaaa     6000



atttttattg tggtaaaata cacataacat ttaccatttt taagtatatt gtttgaacca     6060



tttttaagca tatagttcag tggcattaag tatattcaca ttgttttgca accatgagca     6120



cctattcatc tccagaacat tatcatcatc ctatactaaa acttagaaaa tgtactttta     6180



aacttcttca gttctctttt aatatatgga gcccacccaa aggttatatc atgtaataaa     6240



ctcatttctc tgttttccct cacagcttaa aaatgagaat ttcacttttg ggtcctttct     6300



gcctttaggg ctccctggca ctttgtccag cgtagagcct taagcctcta gatgctttct     6360



agtttcctgg ggccctgagg caagtatctc ttgagaagag gttgctattt ctagaggatc     6420



cacagtgtgc actgtgttgt gctatctaat agtgtggtgg aaatcattta tccagaagtt     6480



gttttttgca acatggaaag atacgtgacc aaaaggaaag ggcaacagca ggagccctgt     6540



tagtgctgcc agaacaccag gaagccttgt gggaggcgta ttgtccaaga tgatgcgtat     6600



tgtccaaacg actcagaaga agtcatttct gaagggttga tcataacttc cctagccatg     6660



ttttacctac agagaactta gttagaattt atgagtacag tatgttaaat tacttttagt     6720



gtaccttagg cagtgtattt gttttgatac agagacaaag actatatgat ccctgagact     6780



tgttgcctag tgaactcaca agcagataga attgtacctc agttatttgg gtgatttaaa     6840



gatggtacta tggctacact attcccagct atcgttgtgt tacagtattt atacaactgg     6900



aaacatctct ctaaatgaca accattgtat attgttaaat aacttatagt cagtggaatt     6960



ctgtgggttt ttctttccta caggcaggaa attatggtga tgtgttgata tgattatata     7020



tgtagactat tcagttaaca tctaggagtt agcaaatttg ctacattcac aatcagtatg     7080



taagtcagtt gtattcctag atatcagcaa ctaacagaaa tggaagtttt tagaaagatc     7140



tcttcaatat cattaaaaaa tacaaaatac tctacctaag aataagtcta acaaaagatg     7200



tacaagatct tgatggagaa aatgttagac catgtcagga agcatttaag gagatcttaa     7260



ataaatgtag tactccataa tgtacacgaa ttagaagact cagtcgtgta aagatgttca     7320



tttacatttg tagattcaat gtaatcccaa ccaaaatatt ttttgcatta ttacctctat     7380



ctactgtgtg tttccttaag acaagggcat tcctacgtaa ccatagtaca accatcaaac     7440



ttaggagatt gacattgaca tcatgatatc taatccatag accacattca atctgctgat     7500



tttgattgcc tcagtaatgt tcctgtgttt cagcatccca atccaggacc acatagtgca     7560



tttagttgcc ctatctcttg tttcattcag tccagaacat cttttcagac ttgtctttga     7620



ccttgacact tgaggaggat tggccagttt gtagaaagtt cctcagtttt ggtttatcat     7680



tagataagac ccataaggtt taggatagac atttttgtcc aatactacag aaatgatgct     7740



ctatactcaa atgtgtcatg ccaggatgca cacaatgtca atttgtctta tacctgatag     7800



tattaatttt ggtcacttgg ttcagatagt atataccagg tttctccatt gtaaaattag     7860



aattaggaag taatttgtga ggagattctt aaagattgta aatgtattgt ttctcatcga     7920



attgtcacgg gctagtctat tgacaattct tgactgaacc aattactatt ttggttgtca     7980



aatggtgagt ccgtggcttc tgccttggtt ggcatcctac tactgtaagg aagagctctt     8040



ccttctctat tccttcattc acttaaatca gtatagattc atgaatgcct gctttattca     8100



gtgacagtgt attattgtca cttattttca tgctgaaatt ttccccgatt tggtttttgg     8160



gagtctcttc aagctggctt ctgtgttcct tagagatgcc tcattgcttt ttcccctctt     8220



atttttttta cgagctcatc ttacactttt tcctactccc taccccaagt ctagaattag     8280



cccttttttc caaggagccc tggtttcttt aaatgggaaa tggtatatgg aaatgaagac     8340



ctgagaaagg ctcactgtct tattggtgaa cagctcaaag gaaaacgtgt gtctacacac     8400



attcaagaat agtcacctac ttctatatct atttatatac atacgtattg aaaactttga     8460



gttcacattg acaccttcaa ttcaatcctt tgaggttaat ctagtctccc tttccatctt     8520



tgtaacttcc ttctctcata gaaacctgac tcccataatc ctaaataatt tgttcattct     8580



tcctccctcc ctcaacctct tgacatgcca gctgctgtct catcacaccc agtcccaaat     8640



atgccaaata aatccgcagt catagcagcg ctggtcctga ccacaccaat ccctaacatc     8700



ctccccagcc tggagcctgg accatggcag ctgaatcttt gaccccagtg atgtcagtcc     8760



tgagcacacc attggaatcc taggctcctg tcatctggct ggaagagaga caaattcaca     8820



accttttgat aatgagcaat tattgaatac tcactgaatt tatcagagaa agtttaaaag     8880



tgtacgatta tacatattta ccaggaatgt ttaaacatag acatttatga aatttataga     8940



aaatattgaa ttgtggttct cactttttgg tcttggctgt aacaattttt aaatattaat     9000



acttcctaca ataactgtat catgctattt ttaagtgtcc tcacactcaa ccaatctact     9060



ctgcatccat aaaataagca tgcagttcag aaaatagatt aaacgactaa ttggctaaaa     9120



a                                                                     9121





<210>  26

<211>  1261

<212>  PRT

<213>  Homo sapiens



<400>  26



Met Ile Ala His Lys Gln Lys Lys Thr Lys Lys Lys Arg Ala Trp Ala 

1               5                   10                  15      





Ser Gly Gln Leu Ser Thr Asp Ile Thr Thr Ser Glu Met Gly Leu Lys 

            20                  25                  30          





Ser Leu Ser Ser Asn Ser Ile Phe Asp Pro Asp Tyr Ile Lys Glu Leu 

        35                  40                  45              





Val Asn Asp Ile Arg Lys Phe Ser His Met Leu Leu Tyr Leu Lys Glu 

    50                  55                  60                  





Ala Ile Phe Ser Asp Cys Phe Lys Glu Val Ile His Ile Arg Leu Glu 

65                  70                  75                  80  





Glu Leu Leu Arg Val Leu Lys Ser Ile Met Asn Lys His Gln Asn Leu 

                85                  90                  95      





Asn Ser Val Asp Leu Gln Asn Ala Ala Glu Met Leu Thr Ala Lys Val 

            100                 105                 110         





Lys Ala Val Asn Phe Thr Glu Val Asn Glu Glu Asn Lys Asn Asp Leu 

        115                 120                 125             





Phe Gln Glu Val Phe Ser Ser Ile Glu Thr Leu Ala Phe Thr Phe Gly 

    130                 135                 140                 





Asn Ile Leu Thr Asn Phe Leu Met Gly Asp Val Gly Asn Asp Ser Leu 

145                 150                 155                 160 





Leu Arg Leu Pro Val Ser Arg Glu Thr Lys Ser Phe Glu Asn Val Ser 

                165                 170                 175     





Val Glu Ser Val Asp Ser Ser Ser Glu Lys Gly Asn Phe Ser Pro Leu 

            180                 185                 190         





Glu Leu Asp Asn Val Leu Leu Lys Asn Thr Asp Ser Ile Glu Leu Ala 

        195                 200                 205             





Leu Ser Tyr Ala Lys Thr Trp Ser Lys Tyr Thr Lys Asn Ile Val Ser 

    210                 215                 220                 





Trp Val Glu Lys Lys Leu Asn Leu Glu Leu Glu Ser Thr Arg Asn Met 

225                 230                 235                 240 





Val Lys Leu Ala Glu Ala Thr Arg Thr Asn Ile Gly Ile Gln Glu Phe 

                245                 250                 255     





Met Pro Leu Gln Ser Leu Phe Thr Asn Ala Leu Leu Asn Asp Ile Glu 

            260                 265                 270         





Ser Ser His Leu Leu Gln Gln Thr Ile Ala Ala Leu Gln Ala Asn Lys 

        275                 280                 285             





Phe Val Gln Pro Leu Leu Gly Arg Lys Asn Glu Met Glu Lys Gln Arg 

    290                 295                 300                 





Lys Glu Ile Lys Glu Leu Trp Lys Gln Glu Gln Asn Lys Met Leu Glu 

305                 310                 315                 320 





Ala Glu Asn Ala Leu Lys Lys Ala Lys Leu Leu Cys Met Gln Arg Gln 

                325                 330                 335     





Asp Glu Tyr Glu Lys Ala Lys Ser Ser Met Phe Arg Ala Glu Glu Glu 

            340                 345                 350         





His Leu Ser Ser Ser Gly Gly Leu Ala Lys Asn Leu Asn Lys Gln Leu 

        355                 360                 365             





Glu Lys Lys Arg Arg Leu Glu Glu Glu Ala Leu Gln Lys Val Glu Glu 

    370                 375                 380                 





Ala Asn Glu Leu Tyr Lys Val Cys Val Thr Asn Val Glu Glu Arg Arg 

385                 390                 395                 400 





Asn Asp Leu Glu Asn Thr Lys Arg Glu Ile Leu Ala Gln Leu Arg Thr 

                405                 410                 415     





Leu Val Phe Gln Cys Asp Leu Thr Leu Lys Ala Val Thr Val Asn Leu 

            420                 425                 430         





Phe His Met Gln His Leu Gln Ala Ala Ser Leu Ala Asp Ser Leu Gln 

        435                 440                 445             





Ser Leu Cys Asp Ser Ala Lys Leu Tyr Asp Pro Gly Gln Glu Tyr Ser 

    450                 455                 460                 





Glu Phe Val Lys Ala Thr Asn Ser Thr Glu Glu Glu Lys Val Asp Gly 

465                 470                 475                 480 





Asn Val Asn Lys His Leu Asn Ser Ser Gln Pro Ser Gly Phe Gly Pro 

                485                 490                 495     





Ala Asn Ser Leu Glu Asp Val Val Arg Leu Pro Asp Ser Ser Asn Lys 

            500                 505                 510         





Ile Glu Glu Asp Arg Cys Ser Asn Ser Ala Asp Ile Thr Gly Pro Ser 

        515                 520                 525             





Phe Ile Arg Ser Trp Thr Phe Gly Met Phe Ser Asp Ser Glu Ser Thr 

    530                 535                 540                 





Gly Gly Ser Ser Glu Ser Arg Ser Leu Asp Ser Glu Ser Ile Ser Pro 

545                 550                 555                 560 





Gly Asp Phe His Arg Lys Leu Pro Arg Thr Pro Ser Ser Gly Thr Met 

                565                 570                 575     





Ser Ser Ala Asp Asp Leu Asp Glu Arg Glu Pro Pro Ser Pro Ser Glu 

            580                 585                 590         





Thr Gly Pro Asn Ser Leu Gly Thr Phe Lys Lys Thr Leu Met Ser Lys 

        595                 600                 605             





Ala Ala Leu Thr His Lys Phe Arg Lys Leu Arg Ser Pro Thr Lys Cys 

    610                 615                 620                 





Arg Asp Cys Glu Gly Ile Val Val Phe Gln Gly Val Glu Cys Glu Glu 

625                 630                 635                 640 





Cys Leu Leu Val Cys His Arg Lys Cys Leu Glu Asn Leu Val Ile Ile 

                645                 650                 655     





Cys Gly His Gln Lys Leu Pro Gly Lys Ile His Leu Phe Gly Ala Glu 

            660                 665                 670         





Phe Thr Gln Val Ala Lys Lys Glu Pro Asp Gly Ile Pro Phe Ile Leu 

        675                 680                 685             





Lys Ile Cys Ala Ser Glu Ile Glu Asn Arg Ala Leu Cys Leu Gln Gly 

    690                 695                 700                 





Ile Tyr Arg Val Cys Gly Asn Lys Ile Lys Thr Glu Lys Leu Cys Gln 

705                 710                 715                 720 





Ala Leu Glu Asn Gly Met His Leu Val Asp Ile Ser Glu Phe Ser Ser 

                725                 730                 735     





His Asp Ile Cys Asp Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu 

            740                 745                 750         





Pro Phe Ile Leu Phe Arg Leu Tyr Lys Glu Phe Ile Asp Leu Ala Lys 

        755                 760                 765             





Glu Ile Gln His Val Asn Glu Glu Gln Glu Thr Lys Lys Asn Ser Leu 

    770                 775                 780                 





Glu Asp Lys Lys Trp Pro Asn Met Cys Ile Glu Ile Asn Arg Ile Leu 

785                 790                 795                 800 





Leu Lys Ser Lys Asp Leu Leu Arg Gln Leu Pro Ala Ser Asn Phe Asn 

                805                 810                 815     





Ser Leu His Phe Leu Ile Val His Leu Lys Arg Val Val Asp His Ala 

            820                 825                 830         





Glu Glu Asn Lys Met Asn Ser Lys Asn Leu Gly Val Ile Phe Gly Pro 

        835                 840                 845             





Ser Leu Ile Arg Pro Arg Pro Thr Thr Ala Pro Ile Thr Ile Ser Ser 

    850                 855                 860                 





Leu Ala Glu Tyr Ser Asn Gln Ala Arg Leu Val Glu Phe Leu Ile Thr 

865                 870                 875                 880 





Tyr Ser Gln Lys Ile Phe Asp Gly Ser Leu Gln Pro Gln Asp Val Met 

                885                 890                 895     





Cys Ser Ile Gly Val Val Asp Gln Gly Cys Phe Pro Lys Pro Leu Leu 

            900                 905                 910         





Ser Pro Glu Glu Arg Asp Ile Glu Arg Ser Met Lys Ser Leu Phe Phe 

        915                 920                 925             





Ser Ser Lys Glu Asp Ile His Thr Ser Glu Ser Glu Ser Lys Ile Phe 

    930                 935                 940                 





Glu Arg Ala Thr Ser Phe Glu Glu Ser Glu Arg Lys Gln Asn Ala Leu 

945                 950                 955                 960 





Gly Lys Cys Asp Ala Cys Leu Ser Asp Lys Ala Gln Leu Leu Leu Asp 

                965                 970                 975     





Gln Glu Ala Glu Ser Ala Ser Gln Lys Ile Glu Asp Gly Lys Thr Pro 

            980                 985                 990         





Lys Pro Leu Ser Leu Lys Ser Asp  Arg Ser Thr Asn Asn  Val Glu Arg 

        995                 1000                 1005             





His Thr  Pro Arg Thr Lys Ile  Arg Pro Val Ser Leu  Pro Val Asp 

    1010                 1015                 1020             





Arg Leu  Leu Leu Ala Ser Pro  Pro Asn Glu Arg Asn  Gly Arg Asn 

    1025                 1030                 1035             





Met Gly  Asn Val Asn Leu Asp  Lys Phe Cys Lys Asn  Pro Ala Phe 

    1040                 1045                 1050             





Glu Gly  Val Asn Arg Lys Asp  Ala Ala Thr Thr Val  Cys Ser Lys 

    1055                 1060                 1065             





Phe Asn  Gly Phe Asp Gln Gln  Thr Leu Gln Lys Ile  Gln Asp Lys 

    1070                 1075                 1080             





Gln Tyr  Glu Gln Asn Ser Leu  Thr Ala Lys Thr Thr  Met Ile Met 

    1085                 1090                 1095             





Pro Ser  Ala Leu Gln Glu Lys  Gly Val Thr Thr Ser  Leu Gln Ile 

    1100                 1105                 1110             





Ser Gly  Asp His Ser Ile Asn  Ala Thr Gln Pro Ser  Lys Pro Tyr 

    1115                 1120                 1125             





Ala Glu  Pro Val Arg Ser Val  Arg Glu Ala Ser Glu  Arg Arg Ser 

    1130                 1135                 1140             





Ser Asp  Ser Tyr Pro Leu Ala  Pro Val Arg Ala Pro  Arg Thr Leu 

    1145                 1150                 1155             





Gln Pro  Gln His Trp Thr Thr  Phe Tyr Lys Pro His  Ala Pro Ile 

    1160                 1165                 1170             





Ile Ser  Ile Arg Gly Asn Glu  Glu Lys Pro Ala Ser  Pro Ser Ala 

    1175                 1180                 1185             





Ala Val  Pro Pro Gly Thr Asp  His Asp Pro His Gly  Leu Val Val 

    1190                 1195                 1200             





Lys Ser  Met Pro Asp Pro Asp  Lys Ala Ser Ala Cys  Pro Gly Gln 

    1205                 1210                 1215             





Ala Thr  Gly Gln Pro Lys Glu  Asp Ser Glu Glu Leu  Gly Leu Pro 

    1220                 1225                 1230             





Asp Val  Asn Pro Met Cys Gln  Arg Pro Arg Leu Lys  Arg Met Gln 

    1235                 1240                 1245             





Gln Phe  Glu Asp Leu Glu Gly  Glu Ile Pro Gln Phe  Val 

    1250                 1255                 1260     





<210>  27

<211>  1858

<212>  DNA

<213>  Homo sapiens



<400>  27

gctgcggccc cgccccctgg ccgcgtggct gcgcgtcctg gctgttgccg ataaagttgt       60



ttgacgccgg cccggcggcg ggtcacgtga gcggaaaatg gcggccccgg caggcggcgg      120



aggctccgcg gtgtcggtgc tggccccgaa cggccggcgc cacacggtga aggtgacgcc      180



gagcaccgtg ctgcttcagg ttctggagga cacgtgccgg cggcaggact tcaacccctg      240



tgaatatgat ctgaagtttc agaggagcgt gctcgacctt tctctccagt ggagatttgc      300



caacctgccc aacaatgcca agctggagat ggtgcccgct tcccggagcc gtgaggggcc      360



tgagaacatg gttcgcatcg ctttgcagct ggacgatggc tcgaggttgc aggactcttt      420



ctgttcaggc cagaccctct gggagcttct cagccatttt ccacagatca gggagtgcct      480



gcagcacccc ggcggggcca ccccagtctg cgtgtacacg agggatgagg tgacgggtga      540



agctgccctg cggggcacga cgctgcagtc gctgggcctg accgggggca gcgccaccat      600



caggtttgtc atgaagtgct acgaccccgt gggcaagacc ccaggaagcc tgggctcgtc      660



agcgtcggct ggccaggcag ccgccagcgc tccacttccc ttggaatctg gggagctcag      720



ccgcggcgac ttgagccgtc cggaggacgc ggacacctca gggccctgct gcgagcacac      780



tcaggagaag cagagcacaa gggcacccgc agctgccccc tttgttcctt tctcgggtgg      840



gggacagaga ctggggggcc ctcctgggcc cacgaggcct ctgacatcat cttcagctaa      900



gttgccgaag tccctctcca gccctggagg cccctccaag ccaaagaagt ccaagtcggg      960



ccaggatccc cagcaggagc aggagcagga gcgggagcgg gatccccagc aggagcagga     1020



gcgggagcgg cccgtggacc gggagcccgt ggaccgggag ccggtggtgt gccaccccga     1080



cctggaggag cggctgcagg cctggccagc ggagctgcct gatgagttct ttgagctgac     1140



ggtggacgac gtgagaagac gcttggccca gctcaagagt gagcggaagc gcctggaaga     1200



agcccccttg gtgaccaagg ccttcaggga ggcgcagata aaggagaagc tggagcgcta     1260



cccaaaggtg gctctgaggg tcctgttccc cgaccgctac gtcctacagg gcttcttccg     1320



ccccagcgag acagtggggg acttgcgaga cttcgtgagg agccacctgg ggaaccccga     1380



gctgtcattt tacctgttca tcacccctcc aaaaacagtc ctggacgacc acacgcagac     1440



cctctttcag gcgaacctct tcccggccgc tctggtgcac ttgggagccg aggagccggc     1500



aggtgtctac ctggagcctg gcctgctgga gcatgccatc tccccatctg cggccgacgt     1560



gctggtggcc aggtacatgt ccagggccgc cgggtcccct tccccattgc cagcccctga     1620



ccctgcacct aagtctgagc cagctgctga ggagggggcg ctggtccccc ctgagcccat     1680



cccagggacg gcccagcccg tgaagaggag cctgggcaag gtgcccaagt ggctgaagct     1740



gccggccagc aagaggtgag agctgccagc ctgaggtgcc cactccgcca gccacaggac     1800



cacctcctct gccagcagga ataaagactt gtgcatccct caaaaaaaaa aaaaaaaa       1858





<210>  28

<211>  553

<212>  PRT

<213>  Homo sapiens



<400>  28



Met Ala Ala Pro Ala Gly Gly Gly Gly Ser Ala Val Ser Val Leu Ala 

1               5                   10                  15      





Pro Asn Gly Arg Arg His Thr Val Lys Val Thr Pro Ser Thr Val Leu 

            20                  25                  30          





Leu Gln Val Leu Glu Asp Thr Cys Arg Arg Gln Asp Phe Asn Pro Cys 

        35                  40                  45              





Glu Tyr Asp Leu Lys Phe Gln Arg Ser Val Leu Asp Leu Ser Leu Gln 

    50                  55                  60                  





Trp Arg Phe Ala Asn Leu Pro Asn Asn Ala Lys Leu Glu Met Val Pro 

65                  70                  75                  80  





Ala Ser Arg Ser Arg Glu Gly Pro Glu Asn Met Val Arg Ile Ala Leu 

                85                  90                  95      





Gln Leu Asp Asp Gly Ser Arg Leu Gln Asp Ser Phe Cys Ser Gly Gln 

            100                 105                 110         





Thr Leu Trp Glu Leu Leu Ser His Phe Pro Gln Ile Arg Glu Cys Leu 

        115                 120                 125             





Gln His Pro Gly Gly Ala Thr Pro Val Cys Val Tyr Thr Arg Asp Glu 

    130                 135                 140                 





Val Thr Gly Glu Ala Ala Leu Arg Gly Thr Thr Leu Gln Ser Leu Gly 

145                 150                 155                 160 





Leu Thr Gly Gly Ser Ala Thr Ile Arg Phe Val Met Lys Cys Tyr Asp 

                165                 170                 175     





Pro Val Gly Lys Thr Pro Gly Ser Leu Gly Ser Ser Ala Ser Ala Gly 

            180                 185                 190         





Gln Ala Ala Ala Ser Ala Pro Leu Pro Leu Glu Ser Gly Glu Leu Ser 

        195                 200                 205             





Arg Gly Asp Leu Ser Arg Pro Glu Asp Ala Asp Thr Ser Gly Pro Cys 

    210                 215                 220                 





Cys Glu His Thr Gln Glu Lys Gln Ser Thr Arg Ala Pro Ala Ala Ala 

225                 230                 235                 240 





Pro Phe Val Pro Phe Ser Gly Gly Gly Gln Arg Leu Gly Gly Pro Pro 

                245                 250                 255     





Gly Pro Thr Arg Pro Leu Thr Ser Ser Ser Ala Lys Leu Pro Lys Ser 

            260                 265                 270         





Leu Ser Ser Pro Gly Gly Pro Ser Lys Pro Lys Lys Ser Lys Ser Gly 

        275                 280                 285             





Gln Asp Pro Gln Gln Glu Gln Glu Gln Glu Arg Glu Arg Asp Pro Gln 

    290                 295                 300                 





Gln Glu Gln Glu Arg Glu Arg Pro Val Asp Arg Glu Pro Val Asp Arg 

305                 310                 315                 320 





Glu Pro Val Val Cys His Pro Asp Leu Glu Glu Arg Leu Gln Ala Trp 

                325                 330                 335     





Pro Ala Glu Leu Pro Asp Glu Phe Phe Glu Leu Thr Val Asp Asp Val 

            340                 345                 350         





Arg Arg Arg Leu Ala Gln Leu Lys Ser Glu Arg Lys Arg Leu Glu Glu 

        355                 360                 365             





Ala Pro Leu Val Thr Lys Ala Phe Arg Glu Ala Gln Ile Lys Glu Lys 

    370                 375                 380                 





Leu Glu Arg Tyr Pro Lys Val Ala Leu Arg Val Leu Phe Pro Asp Arg 

385                 390                 395                 400 





Tyr Val Leu Gln Gly Phe Phe Arg Pro Ser Glu Thr Val Gly Asp Leu 

                405                 410                 415     





Arg Asp Phe Val Arg Ser His Leu Gly Asn Pro Glu Leu Ser Phe Tyr 

            420                 425                 430         





Leu Phe Ile Thr Pro Pro Lys Thr Val Leu Asp Asp His Thr Gln Thr 

        435                 440                 445             





Leu Phe Gln Ala Asn Leu Phe Pro Ala Ala Leu Val His Leu Gly Ala 

    450                 455                 460                 





Glu Glu Pro Ala Gly Val Tyr Leu Glu Pro Gly Leu Leu Glu His Ala 

465                 470                 475                 480 





Ile Ser Pro Ser Ala Ala Asp Val Leu Val Ala Arg Tyr Met Ser Arg 

                485                 490                 495     





Ala Ala Gly Ser Pro Ser Pro Leu Pro Ala Pro Asp Pro Ala Pro Lys 

            500                 505                 510         





Ser Glu Pro Ala Ala Glu Glu Gly Ala Leu Val Pro Pro Glu Pro Ile 

        515                 520                 525             





Pro Gly Thr Ala Gln Pro Val Lys Arg Ser Leu Gly Lys Val Pro Lys 

    530                 535                 540                 





Trp Leu Lys Leu Pro Ala Ser Lys Arg 

545                 550             





<210>  29

<211>  2488

<212>  DNA

<213>  Homo sapiens



<400>  29

ttttgtccgc ctgccgccgc cgtcccagat attaatcacg gagttccagg gagaaggaac       60



ttgtgaaatg ggggagccgg ctggggttgc cggcaccatg gagtcacctt ttagcccggg      120



actctttcac aggctggatg aagattggga ttctgctctc tttgctgaac tcggttattt      180



cacagacact gatgagctgc aattggaagc agcaaatgag acgtatgaaa acaattttga      240



taatcttgat tttgatttgg atttgatgcc ttgggagtca gacatttggg acatcaacaa      300



ccaaatctgt acagttaaag atattaaggc agaacctcag ccactttctc cagcctcctc      360



aagttattca gtctcgtctc ctcggtcagt ggactcttat tcttcaactc agcatgttcc      420



tgaggagttg gatttgtctt ctagttctca gatgtctccc ctttccttat atggtgaaaa      480



ctctaatagt ctctcttcag cggagccact gaaggaagat aagcctgtca ctggtcctag      540



gaacaagact gaaaatggac tgactccaaa gaaaaaaatt caggtgaatt caaaaccttc      600



aattcagccc aagcctttat tgcttccagc agcacccaag actcaaacaa actccagtgt      660



tccagcaaaa accatcatta ttcagacagt accaacgctt atgccattgg caaagcagca      720



accaattatc agtttacaac ctgcacccac taaaggccag acggttttgc tgtctcagcc      780



tactgtggta caacttcaag cacctggagt tctgccctct gctcagccag tccttgctgt      840



tgctggggga gtcacacagc tccctaatca cgtggtgaat gtggtaccag ccccttcagc      900



gaatagccca gtgaatggaa aactttccgt gactaaacct gtcctacaaa gtaccatgag      960



aaatgtcggt tcagatattg ctgtgctaag gagacagcaa cgtatgataa aaaatcgaga     1020



atccgcttgt cagtctcgca agaagaagaa agaatatatg ctagggttag aggcgagatt     1080



aaaggctgcc ctctcagaaa acgagcaact gaagaaagaa aatggaacac tgaagcggca     1140



gctggatgaa gttgtgtcag agaaccagag gcttaaagtc cctagtccaa agcgaagagt     1200



tgtctgtgtg atgatagtat tggcatttat aatactgaac tatggaccta tgagcatgtt     1260



ggaacaggat tccaggagaa tgaaccctag tgtgagccct gcaaatcaaa ggaggcacct     1320



tctaggattt tctgctaaag aggcacagga cacatcagat ggtattatcc agaaaaacag     1380



ctacagatat gatcattctg tttcaaatga caaagccctg atggtgctaa ctgaagaacc     1440



attgctttac attcctccac ctccttgtca gcccctaatt aacacaacag agtctctcag     1500



gttaaatcat gaacttcgag gatgggttca tagacatgaa gtagaaagga ccaagtcaag     1560



aagaatgaca aataatcaac agaaaacccg tattcttcag ggtgctctgg aacagggctc     1620



aaattctcag ctgatggctg ttcaatacac agaaaccact agtagtatca gcaggaactc     1680



agggagtgag ctacaagtgt attatgcttc acccagaagt tatcaagact tttttgaagc     1740



catccgcaga aggggagaca cattttatgt tgtgtcattt cgaagggatc acctgctgtt     1800



accagctacc acccataaca agaccacaag accaaaaatg tcaattgtgt taccagcaat     1860



aaacataaat gagaatgtga tcaatgggca ggactacgaa gtgatgatgc agattgactg     1920



tcaggtgatg gacaccagga tcctccatat caaaagttcg tcagttcctc cttacctccg     1980



agatcagcag aggaatcaaa ccaacacctt ctttggctcc cctcccgcag ccacagaggc     2040



aacccacgtt gtcagcacca tccctgagtc attacaatag caccctgcag ctatgctgga     2100



aaactgagcg tgggaccctg ccagactgaa gagcaggtga gcaaaatgct gctttctgcc     2160



ttggtggcag gcagagaact gtctcgtact agaattcaag gaggaaagaa gaagaaataa     2220



aagaagctgc tccatttttc atcatctacc catctatttg gaaagcactg gaattcagat     2280



gcaagagaac aatgtttctt cagtggcaaa tgtagccctg catcctccag tgttacctgg     2340



tgtagatttt tttttctgta cctttctaaa cctctcttcc ctctgtgatg gttttgtgtt     2400



taaacagtca tcttctttta aataatatcc acctctcctt tttgccattt cacttattga     2460



ttcataaagt gaattttatt taaagcta                                        2488





<210>  30

<211>  670

<212>  PRT

<213>  Homo sapiens



<400>  30



Met Gly Glu Pro Ala Gly Val Ala Gly Thr Met Glu Ser Pro Phe Ser 

1               5                   10                  15      





Pro Gly Leu Phe His Arg Leu Asp Glu Asp Trp Asp Ser Ala Leu Phe 

            20                  25                  30          





Ala Glu Leu Gly Tyr Phe Thr Asp Thr Asp Glu Leu Gln Leu Glu Ala 

        35                  40                  45              





Ala Asn Glu Thr Tyr Glu Asn Asn Phe Asp Asn Leu Asp Phe Asp Leu 

    50                  55                  60                  





Asp Leu Met Pro Trp Glu Ser Asp Ile Trp Asp Ile Asn Asn Gln Ile 

65                  70                  75                  80  





Cys Thr Val Lys Asp Ile Lys Ala Glu Pro Gln Pro Leu Ser Pro Ala 

                85                  90                  95      





Ser Ser Ser Tyr Ser Val Ser Ser Pro Arg Ser Val Asp Ser Tyr Ser 

            100                 105                 110         





Ser Thr Gln His Val Pro Glu Glu Leu Asp Leu Ser Ser Ser Ser Gln 

        115                 120                 125             





Met Ser Pro Leu Ser Leu Tyr Gly Glu Asn Ser Asn Ser Leu Ser Ser 

    130                 135                 140                 





Ala Glu Pro Leu Lys Glu Asp Lys Pro Val Thr Gly Pro Arg Asn Lys 

145                 150                 155                 160 





Thr Glu Asn Gly Leu Thr Pro Lys Lys Lys Ile Gln Val Asn Ser Lys 

                165                 170                 175     





Pro Ser Ile Gln Pro Lys Pro Leu Leu Leu Pro Ala Ala Pro Lys Thr 

            180                 185                 190         





Gln Thr Asn Ser Ser Val Pro Ala Lys Thr Ile Ile Ile Gln Thr Val 

        195                 200                 205             





Pro Thr Leu Met Pro Leu Ala Lys Gln Gln Pro Ile Ile Ser Leu Gln 

    210                 215                 220                 





Pro Ala Pro Thr Lys Gly Gln Thr Val Leu Leu Ser Gln Pro Thr Val 

225                 230                 235                 240 





Val Gln Leu Gln Ala Pro Gly Val Leu Pro Ser Ala Gln Pro Val Leu 

                245                 250                 255     





Ala Val Ala Gly Gly Val Thr Gln Leu Pro Asn His Val Val Asn Val 

            260                 265                 270         





Val Pro Ala Pro Ser Ala Asn Ser Pro Val Asn Gly Lys Leu Ser Val 

        275                 280                 285             





Thr Lys Pro Val Leu Gln Ser Thr Met Arg Asn Val Gly Ser Asp Ile 

    290                 295                 300                 





Ala Val Leu Arg Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala 

305                 310                 315                 320 





Cys Gln Ser Arg Lys Lys Lys Lys Glu Tyr Met Leu Gly Leu Glu Ala 

                325                 330                 335     





Arg Leu Lys Ala Ala Leu Ser Glu Asn Glu Gln Leu Lys Lys Glu Asn 

            340                 345                 350         





Gly Thr Leu Lys Arg Gln Leu Asp Glu Val Val Ser Glu Asn Gln Arg 

        355                 360                 365             





Leu Lys Val Pro Ser Pro Lys Arg Arg Val Val Cys Val Met Ile Val 

    370                 375                 380                 





Leu Ala Phe Ile Ile Leu Asn Tyr Gly Pro Met Ser Met Leu Glu Gln 

385                 390                 395                 400 





Asp Ser Arg Arg Met Asn Pro Ser Val Ser Pro Ala Asn Gln Arg Arg 

                405                 410                 415     





His Leu Leu Gly Phe Ser Ala Lys Glu Ala Gln Asp Thr Ser Asp Gly 

            420                 425                 430         





Ile Ile Gln Lys Asn Ser Tyr Arg Tyr Asp His Ser Val Ser Asn Asp 

        435                 440                 445             





Lys Ala Leu Met Val Leu Thr Glu Glu Pro Leu Leu Tyr Ile Pro Pro 

    450                 455                 460                 





Pro Pro Cys Gln Pro Leu Ile Asn Thr Thr Glu Ser Leu Arg Leu Asn 

465                 470                 475                 480 





His Glu Leu Arg Gly Trp Val His Arg His Glu Val Glu Arg Thr Lys 

                485                 490                 495     





Ser Arg Arg Met Thr Asn Asn Gln Gln Lys Thr Arg Ile Leu Gln Gly 

            500                 505                 510         





Ala Leu Glu Gln Gly Ser Asn Ser Gln Leu Met Ala Val Gln Tyr Thr 

        515                 520                 525             





Glu Thr Thr Ser Ser Ile Ser Arg Asn Ser Gly Ser Glu Leu Gln Val 

    530                 535                 540                 





Tyr Tyr Ala Ser Pro Arg Ser Tyr Gln Asp Phe Phe Glu Ala Ile Arg 

545                 550                 555                 560 





Arg Arg Gly Asp Thr Phe Tyr Val Val Ser Phe Arg Arg Asp His Leu 

                565                 570                 575     





Leu Leu Pro Ala Thr Thr His Asn Lys Thr Thr Arg Pro Lys Met Ser 

            580                 585                 590         





Ile Val Leu Pro Ala Ile Asn Ile Asn Glu Asn Val Ile Asn Gly Gln 

        595                 600                 605             





Asp Tyr Glu Val Met Met Gln Ile Asp Cys Gln Val Met Asp Thr Arg 

    610                 615                 620                 





Ile Leu His Ile Lys Ser Ser Ser Val Pro Pro Tyr Leu Arg Asp Gln 

625                 630                 635                 640 





Gln Arg Asn Gln Thr Asn Thr Phe Phe Gly Ser Pro Pro Ala Ala Thr 

                645                 650                 655     





Glu Ala Thr His Val Val Ser Thr Ile Pro Glu Ser Leu Gln 

            660                 665                 670 





<210>  31

<211>  1820

<212>  DNA

<213>  Homo sapiens



<400>  31

gcggcgacga cggcggcggc agcgctccaa ctggctcctc gctccgggct ccgccgtcga       60



gccgggagag agcctccgcc agcggccagg caccagccag acgacgccag cgaccccggc      120



ctctcggcgg caccgcgcta actcaggggc tgcataggca cccagagccg aactccaaga      180



tgggaggcaa gctcagcaag aagaagaagg gctacaatgt gaacgacgag aaagccaagg      240



agaaagacaa gaaggccgag ggcgcggcga cggaagagga ggggaccccg aaggagagtg      300



agccccaggc ggccgcagag cccgccgagg ccaaggaggg caaggagaag cccgaccagg      360



acgccgaggg caaggccgag gagaaggagg gcgagaagga cgcggcggct gccaaggagg      420



aggccccgaa ggcggagccc gagaagacgg agggcgcggc agaggccaag gctgagcccc      480



cgaaggcgcc cgagcaggag caggcggccc ccggccccgc tgcgggcggc gaggccccca      540



aagctgctga ggccgccgcg gccccggccg agagcgcggc ccctgccgcc ggggaggagc      600



ccagcaagga ggaaggggaa cccaaaaaga ctgaggcgcc cgcagctcct gccgcccagg      660



agaccaaaag tgacggggcc ccagcttcag actcaaaacc cggcagctcg gaggctgccc      720



cctcttccaa ggagaccccc gcagccacgg aagcgcctag ttccacaccc aaggcccagg      780



gccccgcagc ctctgcagaa gagcccaagc cggtggaggc cccggcagct aattccgacc      840



aaaccgtaac cgtgaaagag tgacaaggac agcctatagg aaaaacaata ccacttaaaa      900



caatctcctc tctctctctc tctctctctc tctatctctc tctctatctc ctctctctct      960



ctcctctcct atctctcctc tctctctctc ctatactaac ttgtttcaaa ttggaagtaa     1020



tgatatgtat tgcccaagga aaaatacagg atgttgtccc atcaagggag ggagggggtg     1080



ggagaatcca aatagtattt ttgtggggaa atatctaata taccttcagt caactttacc     1140



aagaagtcct ggatttccaa gatccgcgtc tgaaagtgca gtacatcgtt tgtacctgaa     1200



actgccgcca catgcactcc tccaccgctg agagttgaat agcttttctt ctgcaatggg     1260



agttgggagt gatgcgtttg attctgccca cagggcctgt gccaaggcaa tcagatcttt     1320



atgagagcag tattttctgt gttttctttt taatttacag cctttcttat tttgatattt     1380



ttttaatgtt gtggatgaat gccagctttc agacagagcc cacttagctt gtccacatgg     1440



atctcaatgc caatcctcca ttcttcctct ccagatattt ttgggagtga caaacattct     1500



ctcatcctac ttagcctacc tagatttctc atgacgagtt aatgcatgtc cgtggttggg     1560



tgcacctgta gttctgttta ttggtcagtg gaaatgaaaa aaaaaaaaaa aaaaagtctg     1620



cgttcattgc agttccagtt tctcttccat tctgtgtcac agacaccaac acaccactca     1680



ttggaaaatg gaaaaaaaaa acaaaaaaaa aacaaaaaaa tgtacaatgg atgcattgaa     1740



attatatgta attgtataaa tggtgcaaca gtaataaagt taaacaatta aaaagaaaaa     1800



aaaaaaaaaa aaaaaaaaaa                                                 1820





<210>  32

<211>  227

<212>  PRT

<213>  Homo sapiens



<400>  32



Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 

1               5                   10                  15      





Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu 

            20                  25                  30          





Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 

        35                  40                  45              





Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 

    50                  55                  60                  





Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 

65                  70                  75                  80  





Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala 

                85                  90                  95      





Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 

            100                 105                 110         





Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 

        115                 120                 125             





Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 

    130                 135                 140                 





Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln 

145                 150                 155                 160 





Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 

                165                 170                 175     





Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala 

            180                 185                 190         





Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 

        195                 200                 205             





Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr 

    210                 215                 220                 





Val Lys Glu 

225         





<210>  33

<211>  2606

<212>  DNA

<213>  Homo sapiens



<400>  33

aggacgccac tgccctgtcg ccccgcctgt gcagcccagg acctaggcgc ggtagctggg       60



gctggctttt gaggggcgcg ggcagccttc tgactgggtc ggaggcctgc gggcccgaag      120



cctctgtccc tcctgttctt gtccggcgct gcttagcccc tccgcgtagt catcatggat      180



ctgattttaa accgaatgga ttatctgcag gtgggagtaa catctcagaa gactatgaag      240



ctaattcctg cctcaagaca cagagctaca caaaaggtgg ttattggaga tcatgatggg      300



gtagttatgt gctttggcat gaagaaagga gaagcagcag cagtgttcaa gactttaccc      360



gggccgaaga ttgcaaggct ggaactggga ggggttatca acacacctca ggagaaaatt      420



tttattgctg cagcatctga gattagaggc ttcacaaaaa gaggaaaaca gttcctctcc      480



tttgaaacaa acctcactga aagcattaaa gctatgcaca tatctggctc agacctcttt      540



ctcagtgcaa gttacatcta taaccattat tgtgactgca aagaccaaca ttattacctt      600



tctggggata aaatcaatga tgtgatctgc cttccagtgg aaagattatc tcgtatcaca      660



cctgtattgg cctgccagga cagagtgctc agagttttac agggatctga tgtgatgtat      720



gcagttgaag ttcctggacc ccctactgtc ttagcactac acaatggaaa tggcggtgac      780



tctggagaag accttttgtt tgggacatca gacggaaaac ttgcgcttat acagattact      840



acatccaaac cagtacgcaa gtgggaaatt caaaatgaga aaaagagagg aggtattttg      900



tgtattgaca gctttgacat tgtgggtgat ggggttaaag atttacttgt tgggagagat      960



gacggaatgg tggaagtgta tagttttgat aatgcaaatg aacctgttct acgatttgat     1020



cagatgttgt ctgaaagcgt cacatctatc cagggtggtt gtgtaggaaa agacagctat     1080



gatgaaatcg tggtgtccac atattcaggc tgggttacag gtctgacaac agagcccatt     1140



cataaggaaa gtggaccagg agaagaacta aaaattaatc aggagatgca gaataaaatt     1200



tcttccttac ggaatgagtt ggaacatttg cagtataagg tattgcagga aagagagaat     1260



tatcaacagt cttctcaatc aagcaaagca aaatcagcag taccttcctt tggtataaat     1320



gataaattta cactaaataa agatgatgcc agttacagcc ttatcttaga ggtacagact     1380



gcaatagata atgtcttaat acagagtgat gttccaatag atttacttga tgtggataaa     1440



aattctgctg ttgttagctt tagcagctgt gattctgagt caaacgacaa cttccttctt     1500



gccacttatc ggtgccaggc agatactaca aggctggaac tcaagattcg ctcaattgaa     1560



ggccagtatg gcacactaca agcatatgtg actccaagaa ttcaacccaa aacctgtcag     1620



gtccgccagt accacatcaa acctctttca ctccatcaaa gaactcactt tattgatcat     1680



gacagaccca tgaatacact gaccctaaca ggccagttca gttttgctga agttcactcc     1740



tgggtggttt tttgtctgcc tgaagttcca gaaaaacctc cagcaggaga atgtgtgaca     1800



ttttactttc agaacacctt tctagataca caacttgaaa gtacctacag aaaaggagag     1860



ggagttttta aatctgacaa catttctact atctccatcc taaaagatgt gctttctaaa     1920



gaagctacaa aaaggaaaat taacctcaac atatcatacg agataaatga agtatcagtc     1980



aaacacactt taaagctaat ccacccaaag ctggagtacc agttgctttt ggctaagaaa     2040



gtgcagttaa ttgatgcttt aaaagaatta cagattcatg agggaaatac gaactttctg     2100



ataccagaat atcactgtat tctagaagag gcagatcacc tacaggaaga atacaaaaag     2160



caacctgcac atcttgaaag actctatggt tagtggacca ttctagaata ccttgccata     2220



tttcttttca actggctatt tcccaaggat catgtaagag aagctgggca gaaagataaa     2280



aagattacat cagtcatgat tcatgaacca gtcatgaatc agttgacaac aaatttattg     2340



cacagaatat ttctgtattt tgtcaagcta cttttaatat ttaattcttt tacttgataa     2400



aatgcaagta tattaagaaa taagtatact gtgatgaatt aatctatata tatgaacaaa     2460



cctggtataa aatgaatgta atctatgaac ctttagagct tagactgtat ttcacacaaa     2520



taattgtcat gttttgttgc tattgtgaat tataaaaatg cagcatttaa aatttttaag     2580



gcaaaattta ataaaggata tacagt                                          2606





<210>  34

<211>  672

<212>  PRT

<213>  Homo sapiens



<400>  34



Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr 

1               5                   10                  15      





Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr 

            20                  25                  30          





Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 

        35                  40                  45              





Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro 

    50                  55                  60                  





Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu 

65                  70                  75                  80  





Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg 

                85                  90                  95      





Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys 

            100                 105                 110         





Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 

        115                 120                 125             





Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 

    130                 135                 140                 





Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 

145                 150                 155                 160 





Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 

                165                 170                 175     





Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val 

            180                 185                 190         





Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 

        195                 200                 205             





Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser 

    210                 215                 220                 





Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 

225                 230                 235                 240 





Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 

                245                 250                 255     





Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 

            260                 265                 270         





Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 

        275                 280                 285             





Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 

    290                 295                 300                 





Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu 

305                 310                 315                 320 





Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 

                325                 330                 335     





Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 

            340                 345                 350         





Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 

        355                 360                 365             





Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 

    370                 375                 380                 





Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 

385                 390                 395                 400 





Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 

                405                 410                 415     





Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 

            420                 425                 430         





Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln 

        435                 440                 445             





Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 

    450                 455                 460                 





Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr 

465                 470                 475                 480 





Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 

                485                 490                 495     





Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr 

            500                 505                 510         





Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 

        515                 520                 525             





Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr 

    530                 535                 540                 





Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys 

545                 550                 555                 560 





Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu 

                565                 570                 575     





Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn 

            580                 585                 590         





Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu 

        595                 600                 605             





Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 

    610                 615                 620                 





Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn 

625                 630                 635                 640 





Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 

                645                 650                 655     





Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 

            660                 665                 670         





<210>  35

<211>  3718

<212>  DNA

<213>  Homo sapiens



<400>  35

aggacgccac tgccctgtcg ccccgcctgt gcagcccagg acctaggcgc ggtagctggg       60



gctggctttt gaggggcgcg ggcagccttc tgactgggtc ggaggcctgc gggcccgaag      120



cctctgtccc tcctgttctt gtccggcgct gcttagcccc tccgcgtagt catcatggat      180



ctgattttaa accgaatgga ttatctgcag gtgggagtaa catctcagaa gactatgaag      240



ctaattcctg cctcaagaca cagagctaca caaaaggtgg ttattggaga tcatgatggg      300



gtagttatgt gctttggcat gaagaaagga gaagcagcag cagtgttcaa gactttaccc      360



gggccgaaga ttgcaaggct ggaactggga ggggttatca acacacctca ggagaaaatt      420



tttattgctg cagcatctga gattagaggc ttcacaaaaa gaggaaaaca gttcctctcc      480



tttgaaacaa acctcactga aagcattaaa gctatgcaca tatctggctc agacctcttt      540



ctcagtgcaa gttacatcta taaccattat tgtgactgca aagaccaaca ttattacctt      600



tctggggata aaatcaatga tgtgatctgc cttccagtgg aaagattatc tcgtatcaca      660



cctgtattgg cctgccagga cagagtgctc agagttttac agggatctga tgtgatgtat      720



gcagttgaag ttcctggacc ccctactgtc ttagcactac acaatggaaa tggcggtgac      780



tctggagaag accttttgtt tgggacatca gacggaaaac ttgcgcttat acagattact      840



acatccaaac cagtacgcaa gtgggaaatt caaaatgaga aaaagagagg aggtattttg      900



tgtattgaca gctttgacat tgtgggtgat ggggttaaag atttacttgt tgggagagat      960



gacggaatgg tggaagtgta tagttttgat aatgcaaatg aacctgttct acgatttgat     1020



cagatgttgt ctgaaagcgt cacatctatc cagggtggtt gtgtaggaaa agacagctat     1080



gatgaaatcg tggtgtccac atattcaggc tgggttacag gtctgacaac agagcccatt     1140



cataaggaaa gtggaccagg agaagaacta aaaattaatc aggagatgca gaataaaatt     1200



tcttccttac ggaatgagtt ggaacatttg cagtataagg tattgcagga aagagagaat     1260



tatcaacagt cttctcaatc aagcaaagca aaatcagcag taccttcctt tggtataaat     1320



gataaattta cactaaataa agatgatgcc agttacagcc ttatcttaga ggtacagact     1380



gcaatagata atgtcttaat acagagtgat gttccaatag atttacttga tgtggataaa     1440



aattctgctg ttgttagctt tagcagctgt gattctgagt caaacgacaa cttccttctt     1500



gccacttatc ggtgccaggc agatactaca aggctggaac tcaagattcg ctcaattgaa     1560



ggccagtatg gcacactaca agcatatgtg actccaagaa ttcaacccaa aacctgtcag     1620



gtccgccagt accacatcaa acctctttca ctccatcaaa gaactcactt tattgatcat     1680



gacagaccca tgaatacact gaccctaaca ggccagttca gttttgctga agttcactcc     1740



tgggtggttt tttgtctgcc tgaagttcca gaaaaacctc cagcaggaga atgtgtgaca     1800



ttttactttc agaacacctt tctagataca caacttgaaa gtacctacag aaaaggagag     1860



ggagttttta aatctgacaa catttctact atctccatcc taaaagatgt gctttctaaa     1920



gaagctacaa aaaggaaaat taacctcaac atatcatacg agataaatga agtatcagtc     1980



aaacacactt taaagctaat ccacccaaag ctggagtacc agttgctttt ggctaagaaa     2040



gtgcagttaa ttgatgcttt aaaagaatta cagattcatg agggaaatac gaactttctg     2100



ataccagaat atcactgtat tctagaagag gcagatcacc tacaggaaga atacaaaaag     2160



caacctgcac atcttgaaag actctatggc atgatcactg atcttttcat agataaattt     2220



aagtttaaag gcaccaatgt aaaaactaaa gtaccccttc tattggaaat tctggacagt     2280



tatgaccaaa atgcattgat ttcattcttc gatgcagcat gacatacaaa taaggtaaag     2340



tcccaaagaa gtggtctgtt taaatgaaaa atgttaaaag agaattagaa gttaactgtg     2400



tatgtacttt aatttcaaat gcttttttat atctaaaaat atttgagata taatggcttt     2460



ttaaagtaat gcttctattt cttttgacaa attgaacttt ctaaaactaa aagagtcttt     2520



ttatttttaa aacacaagta gaatgattta aataggattt taatgaattt ttggcaagtg     2580



gctgttttaa tttttaaatt gagaagtaat atgtggaaaa ttaaaatata ttcaaatgta     2640



ttacaaggta cataaacaca taaacatgta gaccgcttta taggcttcaa aatgtatttt     2700



tatatattac cttatttgat cttcacaact gttgtaaaat ttgtcaaatc atataagaaa     2760



actgattctc agtgaaattt tgtgattaag aggacatgct aatattttgt aaagctggga     2820



ccagaaccca agtactggta cttgctttgt gtcctggtta ctatgtatgt tgccagctag     2880



tggaaataac ctaccaattg ttttttctag gagataggat tgatttgcaa ctgatattcc     2940



ttttgcttgg tagtgtttta tgactctgct gcagtttgtg gaaatgctgg acttggctca     3000



gtgctataaa ttgtagccag gaaataagaa gagcttacac agagtcgggg gatcttaatt     3060



agacatgctg taaccagtgg agctattcag cgtgcttcaa gtgaagagtg cagaaatagt     3120



gatgccatct tagattttcc tacactagta tcttctagat ctctttttat catatatgac     3180



attaaggcta cagaagtttt gtgcattaat cttaattcat atttattaat ttcaagggaa     3240



tattgaaagg ttttaaaatg gcatacagat aatggaaaat aagctttatg tttcaagaag     3300



ggcagactca cgaatttttt agaaaacagt gcttcttaat gatatgctat tatacttatt     3360



agttatgtgc aagctttgta tattcttata tttatatata aatataaaaa tttgttaaag     3420



gcacgtatag ttaagagagt tttattttaa taaggtcata ttgtttttac tatgtttaaa     3480



aaactttact tctgaaagga acataattat atctaggtca ctagaacgtc attgtgtttt     3540



ttgttggttg ccacagcttg gggaaaaata gaaaaaaatt aatgactgta tttgaatatt     3600



ttgtaatgca ctgctattta ttatatatat caacagtagt tcaaggtgcc atcttaaatt     3660



aattgcatct tcattaggaa aaataaaaag cataaaacac aaaaaaaaaa aaaaaaaa       3718





<210>  36

<211>  715

<212>  PRT

<213>  Homo sapiens



<400>  36



Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr 

1               5                   10                  15      





Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr 

            20                  25                  30          





Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 

        35                  40                  45              





Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro 

    50                  55                  60                  





Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu 

65                  70                  75                  80  





Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg 

                85                  90                  95      





Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys 

            100                 105                 110         





Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 

        115                 120                 125             





Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 

    130                 135                 140                 





Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 

145                 150                 155                 160 





Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 

                165                 170                 175     





Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val 

            180                 185                 190         





Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 

        195                 200                 205             





Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser 

    210                 215                 220                 





Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 

225                 230                 235                 240 





Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 

                245                 250                 255     





Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 

            260                 265                 270         





Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 

        275                 280                 285             





Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 

    290                 295                 300                 





Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu 

305                 310                 315                 320 





Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 

                325                 330                 335     





Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 

            340                 345                 350         





Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 

        355                 360                 365             





Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 

    370                 375                 380                 





Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 

385                 390                 395                 400 





Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 

                405                 410                 415     





Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 

            420                 425                 430         





Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln 

        435                 440                 445             





Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 

    450                 455                 460                 





Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr 

465                 470                 475                 480 





Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 

                485                 490                 495     





Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr 

            500                 505                 510         





Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 

        515                 520                 525             





Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr 

    530                 535                 540                 





Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys 

545                 550                 555                 560 





Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu 

                565                 570                 575     





Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn 

            580                 585                 590         





Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu 

        595                 600                 605             





Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 

    610                 615                 620                 





Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn 

625                 630                 635                 640 





Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 

                645                 650                 655     





Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 

            660                 665                 670         





Met Ile Thr Asp Leu Phe Ile Asp Lys Phe Lys Phe Lys Gly Thr Asn 

        675                 680                 685             





Val Lys Thr Lys Val Pro Leu Leu Leu Glu Ile Leu Asp Ser Tyr Asp 

    690                 695                 700                 





Gln Asn Ala Leu Ile Ser Phe Phe Asp Ala Ala 

705                 710                 715 





<210>  37

<211>  1893

<212>  DNA

<213>  Homo sapiens



<400>  37

gcttcggggc cgcagagggg gcggggcggg acgtccgggg agtgcgcacg catcctgccc       60



gcggcgcgcg cgcaggtcgg tgcgtctgtc gggggcgcgc tcgggtacct gtaccccacg      120



tagtcgccgg ttaccgatcg gactaagttc cagtggtgat ttacaagtca agttaaaatg      180



tccccagaag tggccttgaa ccgaatatct ccaatgctct cccctttcat atctagcgtg      240



gtccggaatg gaaaagtggg actggatgct acaaactgtt tgaggataac tgacttaaaa      300



tctggctgca catcattgac tcctgggccc aactgtgacc gatttaaact gcacatacca      360



tatgctggag agacattaaa gtgggatatc attttcaatg cccaataccc agaactgcct      420



cccgatttta tctttggaga agatgctgaa ttcctgccag acccctcagc tttgcagaat      480



cttgcctcct ggaatccttc aaatcctgaa tgtctcttac ttgtggtgaa ggaacttgtg      540



caacaatatc accaattcca atgtagccgc ctccgggaga gctcccgcct catgtttgaa      600



taccagacat tactggagga gccacagtat ggagagaaca tggaaattta tgctgggaaa      660



aaaaacaact ggactggtga attttcagct cgtttccttt tgaagctgcc cgtagatttc      720



agcaatatcc ccacatacct tctcaaggat gtaaatgaag accctggaga agatgtggcc      780



ctcctctctg ttagttttga ggacactgaa gccacccagg tgtaccccaa gctgtacttg      840



tcacctcgaa ttgagcatgc acttggaggc tcctcagctc ttcatatccc agcttttcca      900



ggaggaggat gtctcattga ttacgttcct caagtatgcc acctgctcac caacaaggtg      960



cagtacgtga ttcaagggta tcacaaaaga agagagtata ttgctgcttt tctcagtcac     1020



tttggcacag gtgtcgtgga atatgatgca gaaggcttta caaaactcac tctgctgctg     1080



atgtggaaag atttttgttt tcttgtacac attgacctgc ctctgttttt ccctcgagac     1140



cagccaactc tcacatttca gtccgtttat cactttacca acagtggaca gctttactcc     1200



caggcccaaa aaaattatcc gtacagcccc agatgggatg gaaatgaaat ggccaaaaga     1260



gcaaagggat gccaagggag cagagatgcc tgcagcccgt gggagcaagt cctggccttt     1320



gcagttgcaa aaactggctg caagctgctc cagccccaga ggaactggcc aagctccaga     1380



gggcctcctt ggagggcctc agagggagag agaactgctc agtaattttg atcactttgg     1440



gcttatttca aaacctttgt ccctcagttc caggaggcag catttgccaa tggaaagctc     1500



taggaaacac cagtcttgag aggtggccag ccagactgcc tgtccacatg cgtgtcagca     1560



catacagccg cttcctggaa gccgcctgga atgtcttcac ggcagcgttt tgctcacaca     1620



gcagcttttg cacgccccag gcagccccga ctgctgaaat ccaacttgag ctggctggtg     1680



gtccctggat cctagagccc ttcacttcgg gttactccct ctttcttgcc tctatttctt     1740



agttggaaga aataaactca caaattatgg tgcagtaatt ttccggggaa agtaaagcct     1800



caggaatgcc cacgcctttc ttccaaagcc tttgtctctg agacctctta agttctaaga     1860



ttaaatgccc ctcgctgttc ttcctctgaa aaa                                  1893





<210>  38

<211>  415

<212>  PRT

<213>  Homo sapiens



<400>  38



Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 

1               5                   10                  15      





Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 

            20                  25                  30          





Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 

        35                  40                  45              





Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 

    50                  55                  60                  





Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 

65                  70                  75                  80  





Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 

                85                  90                  95      





Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 

            100                 105                 110         





Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 

        115                 120                 125             





Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 

    130                 135                 140                 





Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 

145                 150                 155                 160 





Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 

                165                 170                 175     





Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 

            180                 185                 190         





Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 

        195                 200                 205             





Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 

    210                 215                 220                 





Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 

225                 230                 235                 240 





Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 

                245                 250                 255     





Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 

            260                 265                 270         





Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 

        275                 280                 285             





Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 

    290                 295                 300                 





Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 

305                 310                 315                 320 





Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 

                325                 330                 335     





Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 

            340                 345                 350         





Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Gly Cys Gln Gly Ser 

        355                 360                 365             





Arg Asp Ala Cys Ser Pro Trp Glu Gln Val Leu Ala Phe Ala Val Ala 

    370                 375                 380                 





Lys Thr Gly Cys Lys Leu Leu Gln Pro Gln Arg Asn Trp Pro Ser Ser 

385                 390                 395                 400 





Arg Gly Pro Pro Trp Arg Ala Ser Glu Gly Glu Arg Thr Ala Gln 

                405                 410                 415 





<210>  39

<211>  1720

<212>  DNA

<213>  Homo sapiens



<400>  39

gcttcggggc cgcagagggg gcggggcggg acgtccgggg agtgcgcacg catcctgccc       60



gcggcgcgcg cgcaggtcgg tgcgtctgtc gggggcgcgc tcgggtacct gtaccccacg      120



tagtcgccgg ttaccgatcg gactaagttc cagtggtgat ttacaagtca agttaaaatg      180



tccccagaag tggccttgaa ccgaatatct ccaatgctct cccctttcat atctagcgtg      240



gtccggaatg gaaaagtggg actggatgct acaaactgtt tgaggataac tgacttaaaa      300



tctggctgca catcattgac tcctgggccc aactgtgacc gatttaaact gcacatacca      360



tatgctggag agacattaaa gtgggatatc attttcaatg cccaataccc agaactgcct      420



cccgatttta tctttggaga agatgctgaa ttcctgccag acccctcagc tttgcagaat      480



cttgcctcct ggaatccttc aaatcctgaa tgtctcttac ttgtggtgaa ggaacttgtg      540



caacaatatc accaattcca atgtagccgc ctccgggaga gctcccgcct catgtttgaa      600



taccagacat tactggagga gccacagtat ggagagaaca tggaaattta tgctgggaaa      660



aaaaacaact ggactggtga attttcagct cgtttccttt tgaagctgcc cgtagatttc      720



agcaatatcc ccacatacct tctcaaggat gtaaatgaag accctggaga agatgtggcc      780



ctcctctctg ttagttttga ggacactgaa gccacccagg tgtaccccaa gctgtacttg      840



tcacctcgaa ttgagcatgc acttggaggc tcctcagctc ttcatatccc agcttttcca      900



ggaggaggat gtctcattga ttacgttcct caagtatgcc acctgctcac caacaaggtg      960



cagtacgtga ttcaagggta tcacaaaaga agagagtata ttgctgcttt tctcagtcac     1020



tttggcacag gtgtcgtgga atatgatgca gaaggcttta caaaactcac tctgctgctg     1080



atgtggaaag atttttgttt tcttgtacac attgacctgc ctctgttttt ccctcgagac     1140



cagccaactc tcacatttca gtccgtttat cactttacca acagtggaca gctttactcc     1200



caggcccaaa aaaattatcc gtacagcccc agatgggatg gaaatgaaat ggccaaaaga     1260



gcaaaggctt atttcaaaac ctttgtccct cagttccagg aggcagcatt tgccaatgga     1320



aagctctagg aaacaccagt cttgagaggt ggccagccag actgcctgtc cacatgcgtg     1380



tcagcacata cagccgcttc ctggaagccg cctggaatgt cttcacggca gcgttttgct     1440



cacacagcag cttttgcacg ccccaggcag ccccgactgc tgaaatccaa cttgagctgg     1500



ctggtggtcc ctggatccta gagcccttca cttcgggtta ctccctcttt cttgcctcta     1560



tttcttagtt ggaagaaata aactcacaaa ttatggtgca gtaattttcc ggggaaagta     1620



aagcctcagg aatgcccacg cctttcttcc aaagcctttg tctctgagac ctcttaagtt     1680



ctaagattaa atgcccctcg ctgttcttcc tctgaaaaaa                           1720





<210>  40

<211>  383

<212>  PRT

<213>  Homo sapiens



<400>  40



Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 

1               5                   10                  15      





Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 

            20                  25                  30          





Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 

        35                  40                  45              





Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 

    50                  55                  60                  





Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 

65                  70                  75                  80  





Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 

                85                  90                  95      





Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 

            100                 105                 110         





Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 

        115                 120                 125             





Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 

    130                 135                 140                 





Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 

145                 150                 155                 160 





Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 

                165                 170                 175     





Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 

            180                 185                 190         





Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 

        195                 200                 205             





Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 

    210                 215                 220                 





Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 

225                 230                 235                 240 





Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 

                245                 250                 255     





Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 

            260                 265                 270         





Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 

        275                 280                 285             





Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 

    290                 295                 300                 





Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 

305                 310                 315                 320 





Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 

                325                 330                 335     





Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 

            340                 345                 350         





Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Ala Tyr Phe Lys Thr 

        355                 360                 365             





Phe Val Pro Gln Phe Gln Glu Ala Ala Phe Ala Asn Gly Lys Leu 

    370                 375                 380             





<210>  41

<211>  1791

<212>  DNA

<213>  Homo sapiens



<400>  41

gcttcggggc cgcagagggg gcggggcggg acgtccgggg agtgcgcacg catcctgccc       60



gcggcgcgcg cgcaggtcgg tgcgtctgtc gggggcgcgc tcgggtacct gtaccccacg      120



tagtcgccgg ttaccgatcg gactaagttc cagtggtgat ttacaagtca agttaaaatg      180



tccccagaag tggccttgaa ccgaatatct ccaatgctct cccctttcat atctagcgtg      240



gtccggaatg gaaaagtggg actggatgct acaaactgtt tgaggataac tgacttaaaa      300



tctggctgca catcattgac tcctgggccc aactgtgacc gatttaaact gcacatacca      360



tatgctggag agacattaaa gtgggatatc attttcaatg cccaataccc agaactgcct      420



cccgatttta tctttggaga agatgctgaa ttcctgccag acccctcagc tttgcagaat      480



cttgcctcct ggaatccttc aaatcctgaa tgtctcttac ttgtggtgaa ggaacttgtg      540



caacaatatc accaattcca atgtagccgc ctccgggaga gctcccgcct catgtttgaa      600



taccagacat tactggagga gccacagtat ggagagaaca tggaaattta tgctgggaaa      660



aaaaacaact ggactggtga attttcagct cgtttccttt tgaagctgcc cgtagatttc      720



agcaatatcc ccacatacct tctcaaggat gtaaatgaag accctggaga agatgtggcc      780



ctcctctctg ttagttttga ggacactgaa gccacccagg tgtaccccaa gctgtacttg      840



tcacctcgaa ttgagcatgc acttggaggc tcctcagctc ttcatatccc agcttttcca      900



ggaggaggat gtctcattga ttacgttcct caagtatgcc acctgctcac caacaaggtg      960



cagtacgtga ttcaagggta tcacaaaaga agagagtata ttgctgcttt tctcagtcac     1020



tttggcacag gtgtcgtgga atatgatgca gaaggcttta caaaactcac tctgctgctg     1080



atgtggaaag atttttgttt tcttgtacac attgacctgc ctctgttttt ccctcgagac     1140



cagccaactc tcacatttca gtccgtttat cactttacca acagtggaca gctttactcc     1200



caggcccaaa aaaattatcc gtacagcccc agatgggatg gaaatgaaat ggccaaaaga     1260



gcaaaaagag agagcaacag agatggggag gaatccagct ctgcctgaca tccaggcatc     1320



ctctccaaat tgcatagggc ttatttcaaa acctttgtcc ctcagttcca ggaggcagca     1380



tttgccaatg gaaagctcta ggaaacacca gtcttgagag gtggccagcc agactgcctg     1440



tccacatgcg tgtcagcaca tacagccgct tcctggaagc cgcctggaat gtcttcacgg     1500



cagcgttttg ctcacacagc agcttttgca cgccccaggc agccccgact gctgaaatcc     1560



aacttgagct ggctggtggt ccctggatcc tagagccctt cacttcgggt tactccctct     1620



ttcttgcctc tatttcttag ttggaagaaa taaactcaca aattatggtg cagtaatttt     1680



ccggggaaag taaagcctca ggaatgccca cgcctttctt ccaaagcctt tgtctctgag     1740



acctcttaag ttctaagatt aaatgcccct cgctgttctt cctctgaaaa a              1791





<210>  42

<211>  376

<212>  PRT

<213>  Homo sapiens



<400>  42



Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 

1               5                   10                  15      





Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 

            20                  25                  30          





Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 

        35                  40                  45              





Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 

    50                  55                  60                  





Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 

65                  70                  75                  80  





Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 

                85                  90                  95      





Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 

            100                 105                 110         





Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 

        115                 120                 125             





Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 

    130                 135                 140                 





Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 

145                 150                 155                 160 





Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 

                165                 170                 175     





Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 

            180                 185                 190         





Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 

        195                 200                 205             





Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 

    210                 215                 220                 





Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 

225                 230                 235                 240 





Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 

                245                 250                 255     





Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 

            260                 265                 270         





Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 

        275                 280                 285             





Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 

    290                 295                 300                 





Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 

305                 310                 315                 320 





Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 

                325                 330                 335     





Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 

            340                 345                 350         





Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Arg Glu Ser Asn Arg 

        355                 360                 365             





Asp Gly Glu Glu Ser Ser Ser Ala 

    370                 375     





<210>  43

<211>  1932

<212>  DNA

<213>  Homo sapiens



<400>  43

ggaactgtca ggcaccgcgg ggacgccttt ccgagcgccc ggctcggcgc ggcgcggggg       60



cgcgcacgcc gccgagcttc ggggccgcag agggggcggg gcgggacgtc cggggagtgc      120



gcacgcatcc tgcccgcggc gcgcgcgcag gtcggtgcgt ctgtcggggg cgcgctcggg      180



tacctgtacc ccacgtagtc gccggttacc gatcggacta agttccagaa gcaagagata      240



aagtaataat gggtactgtg gggaaaaaca cagaagaaca attcggtaat atagtggtga      300



tttacaagtc aagttaaaat gtccccagaa gtggccttga accgaatatc tccaatgctc      360



tcccctttca tatctagcgt ggtccggaat ggaaaagtgg gactggatgc tacaaactgt      420



ttgaggataa ctgacttaaa atctggctgc acatcattga ctcctgggcc caactgtgac      480



cgatttaaac tgcacatacc atatgctgga gagacattaa agtgggatat cattttcaat      540



gcccaatacc cagaactgcc tcccgatttt atctttggag aagatgctga attcctgcca      600



gacccctcag ctttgcagaa tcttgcctcc tggaatcctt caaatcctga atgtctctta      660



cttgtggtga aggaacttgt gcaacaatat caccaattcc aatgtagccg cctccgggag      720



agctcccgcc tcatgtttga ataccagaca ttactggagg agccacagta tggagagaac      780



atggaaattt atgctgggaa aaaaaacaac tggactggtg aattttcagc tcgtttcctt      840



ttgaagctgc ccgtagattt cagcaatatc cccacatacc ttctcaagga tgtaaatgaa      900



gaccctggag aagatgtggc cctcctctct gttagttttg aggacactga agccacccag      960



gtgtacccca agctgtactt gtcacctcga attgagcatg cacttggagg ctcctcagct     1020



cttcatatcc cagcttttcc aggaggagga tgtctcattg attacgttcc tcaagtatgc     1080



cacctgctca ccaacaaggt gcagtacgtg attcaagggt atcacaaaag aagagagtat     1140



attgctgctt ttctcagtca ctttggcaca ggtgtcgtgg aatatgatgc agaaggcttt     1200



acaaaactca ctctgctgct gatgtggaaa gatttttgtt ttcttgtaca cattgacctg     1260



cctctgtttt tccctcgaga ccagccaact ctcacatttc agtccgttta tcactttacc     1320



aacagtggac agctttactc ccaggcccaa aaaaattatc cgtacagccc cagatgggat     1380



ggaaatgaaa tggccaaaag agcaaaaaga gagagcaaca gagatgggga ggaatccagc     1440



tctgcctgac atccaggcat cctctccaaa ttgcataggg cttatttcaa aacctttgtc     1500



cctcagttcc aggaggcagc atttgccaat ggaaagctct aggaaacacc agtcttgaga     1560



ggtggccagc cagactgcct gtccacatgc gtgtcagcac atacagccgc ttcctggaag     1620



ccgcctggaa tgtcttcacg gcagcgtttt gctcacacag cagcttttgc acgccccagg     1680



cagccccgac tgctgaaatc caacttgagc tggctggtgg tccctggatc ctagagccct     1740



tcacttcggg ttactccctc tttcttgcct ctatttctta gttggaagaa ataaactcac     1800



aaattatggt gcagtaattt tccggggaaa gtaaagcctc aggaatgccc acgcctttct     1860



tccaaagcct ttgtctctga gacctcttaa gttctaagat taaatgcccc tcgctgttct     1920



tcctctgaaa aa                                                         1932





<210>  44

<211>  376

<212>  PRT

<213>  Homo sapiens



<400>  44



Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 

1               5                   10                  15      





Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 

            20                  25                  30          





Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 

        35                  40                  45              





Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 

    50                  55                  60                  





Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 

65                  70                  75                  80  





Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 

                85                  90                  95      





Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 

            100                 105                 110         





Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 

        115                 120                 125             





Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 

    130                 135                 140                 





Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 

145                 150                 155                 160 





Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 

                165                 170                 175     





Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 

            180                 185                 190         





Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 

        195                 200                 205             





Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 

    210                 215                 220                 





Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 

225                 230                 235                 240 





Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 

                245                 250                 255     





Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 

            260                 265                 270         





Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 

        275                 280                 285             





Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 

    290                 295                 300                 





Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 

305                 310                 315                 320 





Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 

                325                 330                 335     





Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 

            340                 345                 350         





Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Arg Glu Ser Asn Arg 

        355                 360                 365             





Asp Gly Glu Glu Ser Ser Ser Ala 

    370                 375     





<210>  45

<211>  1860

<212>  DNA

<213>  Homo sapiens



<400>  45

ggaactgtca ggcaccgcgg ggacgccttt ccgagcgccc ggctcggcgc ggcgcggggg       60



cgcgcacgcc gccgagcttc ggggccgcag agggggcggg gcgggacgtc cggggagtgc      120



gcacgcatcc tgcccgcggc gcgcgcgcag gtcggtgcgt ctgtcggggg cgcgctcggg      180



tacctgtacc ccacgtagtc gccggttacc gatcggacta agttccagaa gcaagagata      240



aagtaataat gggtactgtg gggaaaaaca cagaagaaca attcggtaat atagtggtga      300



tttacaagtc aagttaaaat gtccccagaa gtggccttga accgaatatc tccaatgctc      360



tcccctttca tatctagcgt ggtccggaat ggaaaagtgg gactggatgc tacaaactgt      420



ttgaggataa ctgacttaaa atctggctgc acatcattga ctcctgggcc caactgtgac      480



cgatttaaac tgcacatacc atatgctgga gagacattaa agtgggatat cattttcaat      540



gcccaatacc cagaactgcc tcccgatttt atctttggag aagatgctga attcctgcca      600



gacccctcag ctttgcagaa tcttgcctcc tggaatcctt caaatcctga atgtctctta      660



cttgtggtga aggaacttgt gcaacaatat caccaattcc aatgtagccg cctccgggag      720



agctcccgcc tcatgtttga ataccagaca ttactggagg agccacagta tggagagaac      780



atggaaattt atgctgggaa aaaaaacaac tggactggtg aattttcagc tcgtttcctt      840



ttgaagctgc ccgtagattt cagcaatatc cccacatacc ttctcaagga tgtaaatgaa      900



gaccctggag aagatgtggc cctcctctct gttagttttg aggacactga agccacccag      960



gtgtacccca agctgtactt gtcacctcga attgagcatg cacttggagg ctcctcagct     1020



cttcatatcc cagcttttcc aggaggagga tgtctcattg attacgttcc tcaagtatgc     1080



cacctgctca ccaacaaggt gcagtacgtg attcaagggt atcacaaaag aagagagtat     1140



attgctgctt ttctcagtca ctttggcaca ggtgtcgtgg aatatgatgc agaaggcttt     1200



acaaaactca ctctgctgct gatgtggaaa gatttttgtt ttcttgtaca cattgacctg     1260



cctctgtttt tccctcgaga ccagccaact ctcacatttc agtccgttta tcactttacc     1320



aacagtggac agctttactc ccaggcccaa aaaaattatc cgtacagccc cagatgggat     1380



ggaaatgaaa tggccaaaag agcaaaggct tatttcaaaa cctttgtccc tcagttccag     1440



gaggcagcat ttgccaatgg aaagctctag gaaacaccag tcttgagagg tggccagcca     1500



gactgcctgt ccacatgcgt gtcagcacat acagccgctt cctggaagcc gcctggaatg     1560



tcttcacggc agcgttttgc tcacacagca gcttttgcac gccccaggca gccccgactg     1620



ctgaaatcca acttgagctg gctggtggtc cctggatcct agagcccttc acttcgggtt     1680



actccctctt tcttgcctct atttcttagt tggaagaaat aaactcacaa attatggtgc     1740



agtaattttc cggggaaagt aaagcctcag gaatgcccac gcctttcttc caaagccttt     1800



gtctctgaga cctcttaagt tctaagatta aatgcccctc gctgttcttc ctctgaaaaa     1860





<210>  46

<211>  383

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 

1               5                   10                  15      





Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 

            20                  25                  30          





Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 

        35                  40                  45              





Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 

    50                  55                  60                  





Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 

65                  70                  75                  80  





Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 

                85                  90                  95      





Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 

            100                 105                 110         





Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 

        115                 120                 125             





Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 

    130                 135                 140                 





Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 

145                 150                 155                 160 





Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 

                165                 170                 175     





Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 

            180                 185                 190         





Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 

        195                 200                 205             





Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 

    210                 215                 220                 





Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 

225                 230                 235                 240 





Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 

                245                 250                 255     





Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 

            260                 265                 270         





Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 

        275                 280                 285             





Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 

    290                 295                 300                 





Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 

305                 310                 315                 320 





Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 

                325                 330                 335     





Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 

            340                 345                 350         





Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Ala Tyr Phe Lys Thr 

        355                 360                 365             





Phe Val Pro Gln Phe Gln Glu Ala Ala Phe Ala Asn Gly Lys Leu 

    370                 375                 380             





<210>  47

<211>  1867

<212>  DNA

<213>  Homo sapiens



<400>  47

ggggctgcgc cgggttccgt gtgtctatgt caatgtgtct gtccttcact cctccattgt       60



ctgccgccac tgctgctgct gctgctgctg ccgctgctgc tgcacgaatc gccgcagccc      120



ccagccttgc gcgtcgtcgc tacctcctcg gacagaaatt ttatgaataa gcatcagaag      180



ccagtgctaa caggccagcg gttcaaaact cggaaaaggg atgaaaaaga gaaattcgaa      240



cccacagtct tcagggatac acttgtccag gggcttaatg aggctggtga tgaccttgaa      300



gctgtagcca aatttctgga ctctacaggc tcaagattag attatcgtcg ctatgcagac      360



acactcttcg atatcctggt ggctggcagt atgcttgccc ctggaggaac gcgcatagat      420



gatggtgaca agaccaagat gaccaaccac tgtgtgtttt cagcaaatga agatcatgaa      480



accatccgaa actatgctca ggtcttcaat aaactcatca ggagatataa gtatttggag      540



aaggcatttg aagatgaaat gaaaaagctt ctcctcttcc ttaaagcctt ttccgaaaca      600



gagcagacaa agttggcgat gctgtcgggg attctgctgg gcaatggcac cctgcccgcc      660



accatcctca ccagtctctt caccgacagc ttagtcaaag aaggcattgc ggcctcattt      720



gctgtcaagc ttttcaaagc atggatggca gaaaaagatg ccaactctgt tacctcgtct      780



ttgagaaaag ccaacttaga caagaggctg cttgaactct ttccagttaa cagacagagt      840



gtggatcatt ttgctaaata cttcactgac gcaggtctta aggagctttc cgacttcctc      900



cgagtccagc agtccctggg caccaggaag gaactgcaga aggagctcca ggagcgtctt      960



tctcaggaat gcccgatcaa ggaggtggtg ctttatgtca aagaagaaat gaagaggaat     1020



gatcttccag aaacagcagt gattggtctt ctgtggacat gtataatgaa cgctgttgag     1080



tggaacaaga aggaagaact tgttgcagag caggctctga agcacctgaa gcaatatgct     1140



cccctgctgg ccgtgttcag ctcccaaggc cagtcagagc tgatcctcct ccagaaggtt     1200



caggaatact gctacgacaa catccatttc atgaaagcct ttcagaagat tgtggttctc     1260



ttttataaag ctgatgttct gagcgaagaa gcaatactga aatggtataa ggaagcacat     1320



gttgctaaag gcaaaagtgt ttttcttgac cagatgaaga aatttgttga gtggttacaa     1380



aatgcagaag aagaatccga atcggaaggt gaggaaaatt aaatggctca acaagcacaa     1440



tacctaggtt accacacacc actttttgat tgggaatgct gaaccatttg agaagagaaa     1500



cttggcttct gttttcgcaa aggaaaaaaa aaataggata ggcttccctt gtgcagaggg     1560



agaaatggtt ttgtttttgt tttgttttta aatggagccc tgaggcatca gctattatac     1620



ttgggactct acctctcact cactatatgc taacttaaag ccattcaaca aggagtcaag     1680



tagatctgaa attaaatact caacagactc ctcctttttt agctgtattt ttcaggtact     1740



gtgtggtgac cgccccactg gtgtctatta caggccactt tggtagttgt gtatctgctc     1800



atgtatgtga tttgacaaac cagtttttta aaataaatgg ctttttaaaa atctgggaaa     1860



aaaaaaa                                                               1867





<210>  48

<211>  419

<212>  PRT

<213>  Homo sapiens



<400>  48



Met Asn Lys His Gln Lys Pro Val Leu Thr Gly Gln Arg Phe Lys Thr 

1               5                   10                  15      





Arg Lys Arg Asp Glu Lys Glu Lys Phe Glu Pro Thr Val Phe Arg Asp 

            20                  25                  30          





Thr Leu Val Gln Gly Leu Asn Glu Ala Gly Asp Asp Leu Glu Ala Val 

        35                  40                  45              





Ala Lys Phe Leu Asp Ser Thr Gly Ser Arg Leu Asp Tyr Arg Arg Tyr 

    50                  55                  60                  





Ala Asp Thr Leu Phe Asp Ile Leu Val Ala Gly Ser Met Leu Ala Pro 

65                  70                  75                  80  





Gly Gly Thr Arg Ile Asp Asp Gly Asp Lys Thr Lys Met Thr Asn His 

                85                  90                  95      





Cys Val Phe Ser Ala Asn Glu Asp His Glu Thr Ile Arg Asn Tyr Ala 

            100                 105                 110         





Gln Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Ala 

        115                 120                 125             





Phe Glu Asp Glu Met Lys Lys Leu Leu Leu Phe Leu Lys Ala Phe Ser 

    130                 135                 140                 





Glu Thr Glu Gln Thr Lys Leu Ala Met Leu Ser Gly Ile Leu Leu Gly 

145                 150                 155                 160 





Asn Gly Thr Leu Pro Ala Thr Ile Leu Thr Ser Leu Phe Thr Asp Ser 

                165                 170                 175     





Leu Val Lys Glu Gly Ile Ala Ala Ser Phe Ala Val Lys Leu Phe Lys 

            180                 185                 190         





Ala Trp Met Ala Glu Lys Asp Ala Asn Ser Val Thr Ser Ser Leu Arg 

        195                 200                 205             





Lys Ala Asn Leu Asp Lys Arg Leu Leu Glu Leu Phe Pro Val Asn Arg 

    210                 215                 220                 





Gln Ser Val Asp His Phe Ala Lys Tyr Phe Thr Asp Ala Gly Leu Lys 

225                 230                 235                 240 





Glu Leu Ser Asp Phe Leu Arg Val Gln Gln Ser Leu Gly Thr Arg Lys 

                245                 250                 255     





Glu Leu Gln Lys Glu Leu Gln Glu Arg Leu Ser Gln Glu Cys Pro Ile 

            260                 265                 270         





Lys Glu Val Val Leu Tyr Val Lys Glu Glu Met Lys Arg Asn Asp Leu 

        275                 280                 285             





Pro Glu Thr Ala Val Ile Gly Leu Leu Trp Thr Cys Ile Met Asn Ala 

    290                 295                 300                 





Val Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln Ala Leu Lys 

305                 310                 315                 320 





His Leu Lys Gln Tyr Ala Pro Leu Leu Ala Val Phe Ser Ser Gln Gly 

                325                 330                 335     





Gln Ser Glu Leu Ile Leu Leu Gln Lys Val Gln Glu Tyr Cys Tyr Asp 

            340                 345                 350         





Asn Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr 

        355                 360                 365             





Lys Ala Asp Val Leu Ser Glu Glu Ala Ile Leu Lys Trp Tyr Lys Glu 

    370                 375                 380                 





Ala His Val Ala Lys Gly Lys Ser Val Phe Leu Asp Gln Met Lys Lys 

385                 390                 395                 400 





Phe Val Glu Trp Leu Gln Asn Ala Glu Glu Glu Ser Glu Ser Glu Gly 

                405                 410                 415     





Glu Glu Asn 

            





<210>  49

<211>  2213

<212>  DNA

<213>  Homo sapiens



<400>  49

gagtcctcct ttttgcacac acacgaatac aaagagccat acgaccttcg gtttcaggtt       60



tagctgtgcc tcccagtgac tataatgaca aggaagctgt aaatgtattt gagttaagct      120



tttgcgagaa accctacagc ttggggcctg ggctcctctg accatcctca ttgagaaagg      180



aaagtgagtc cagagaagtt gatgcttcct acctgttgga gcggcccagc agtgtaagcg      240



tggttgttac tgccccatcc gccatgtcct tcagtgccac cattctcttc tcccctccca      300



gtggcagcga ggccagatgc tgctgctgcg cctgtaagag tgagactaat ggaggcaaca      360



caggctccca gggtgggaat cctcctccca gcacccccat cacagtgact ggacatggct      420



tggctgttca gagctcagag cagctcctgc atgttatcta ccagcgggtc gataaggcag      480



tgggtttggc tgaagctgct ctgggtcttg ccagggccaa caatgagttg ttaaaacgtc      540



tccaggagga agtgggtgac ctgaggcaag ggaaagtgtc catccctgat gaagatgggg      600



aaagccgggc acatagttcc ccacctgagg agcctgggcc tctcaaggaa agtcccgggg      660



aagcctttaa ggctctgtct gccgtggaag aggagtgtga cagcgtgggc agcggcgtgc      720



aggtggtgat tgaggagctg cggcagctgg gagcagcctc agtggggcct gggcctttgg      780



gcttcccagc aactcagagg gacatgcggc tcccagggtg cacgctggct gccagcgagg      840



cggcccccct gctcaatcct ctggtggatg attacgtggc ctctgagggt gcagtacagc      900



gagttctggt ccctgcttat gccaagcaac tctcaccagc cacacaactg gcaatccagc      960



gggcaacccc agagacagga ccagaaaatg gaaccaagct gccaccaccc cgccctgagg     1020



acatgctcaa tgccgctgct gcgctggaca gtgccttgga agagtcaggc cctgggagca     1080



ctggggagct gagacactct ctagggctga ccgtttcccc atgcaggacc agaggaagtg     1140



ggcagaagaa ctccaggcgc aagcgggatc ttgtactctc taaactggtc cacaatgtgc     1200



ataaccacat caccaatgac aagagattca atgggtctga aagcatcaag tcctcttgga     1260



atatttcagt agtgaagttt cttctggaaa agctcaagca agagctggtg accagtcccc     1320



acaattacac tgataaggag ctaaaaggag cctgtgtggc ctacttcctt actaagaggc     1380



gtgagtaccg caactccctg aaccccttta aaggcctgaa ggaaaaagag gagaagaaac     1440



ttcgaagtcg ccgatatcgg ctttttgcca accgatccag tatcatgagg cattttggac     1500



ctgaggacca acgtctgtgg aatgatgtga cagaggaact gatgtcagat gaagaggaca     1560



gtcttaacga gccaggtgtg tgggtggccc gccctccccg tttccgggcc cagcgcctca     1620



cagagctctg ctaccacctg gatgctaact ctaagcatgg caccaaagcc aaccgtgtgt     1680



atgggcctcc ctcagacaga ctgccttctg ctgaagccca gctccttcca ccagaacttt     1740



acaatcctaa tttccaagaa gaggaagatg agggagggga tgagaatgca cctggctccc     1800



catcttttga ccaaccccac aaaacctgct gtcctgactt gaactcattc attgaaatca     1860



aggtggaaaa ggatgaataa aatctacagc caagaataac tctggcttcc gccatgcccc     1920



atgtctcaga aataggtggc catggggctt cacaaaataa tgagatgctc tgtgcagtct     1980



gagaaagcaa atttgcctct tttcttaaca cagtctctac tggggaagca gaacactggt     2040



gggataaaaa cttatctaga aggggagaaa ctccctccac tgtgaacagt aagccagaat     2100



atgcttattc ctcagcataa acagtatctc ggagaagcct gggatgagaa aatgaggagg     2160



atgggtccaa gaaacatgag gccttcttga cataaaaaaa aaaaaaaaaa aaa            2213





<210>  50

<211>  538

<212>  PRT

<213>  Homo sapiens



<400>  50



Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 

1               5                   10                  15      





Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 

            20                  25                  30          





Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 

        35                  40                  45              





Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 

    50                  55                  60                  





Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 

65                  70                  75                  80  





Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 

                85                  90                  95      





Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 

            100                 105                 110         





Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 

        115                 120                 125             





Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 

    130                 135                 140                 





Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 

145                 150                 155                 160 





Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 

                165                 170                 175     





Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 

            180                 185                 190         





Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 

        195                 200                 205             





Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 

    210                 215                 220                 





Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 

225                 230                 235                 240 





Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 

                245                 250                 255     





Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 

            260                 265                 270         





Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 

        275                 280                 285             





Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 

    290                 295                 300                 





Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 

305                 310                 315                 320 





Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 

                325                 330                 335     





Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 

            340                 345                 350         





His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 

        355                 360                 365             





Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 

    370                 375                 380                 





Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 

385                 390                 395                 400 





Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 

                405                 410                 415     





Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 

            420                 425                 430         





Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg 

        435                 440                 445             





Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys 

    450                 455                 460                 





His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu 

465                 470                 475                 480 





Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn 

                485                 490                 495     





Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser 

            500                 505                 510         





Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser 

        515                 520                 525             





Phe Ile Glu Ile Lys Val Glu Lys Asp Glu 

    530                 535             





<210>  51

<211>  2134

<212>  DNA

<213>  Homo sapiens



<400>  51

gagtcctcct ttttgcacac acacgaatac aaagagccat acgaccttcg gaccctacag       60



cttggggcct gggctcctct gaccatcctc attgagaaag gaaagtgagt ccagagaagt      120



tgatgcttcc tacctgttgg agcggcccag cagtgtaagc gtggttgtta ctgccccatc      180



cgccatgtcc ttcagtgcca ccattctctt ctcccctccc agtggcagcg aggccagatg      240



ctgctgctgc gcctgtaaga gtgagactaa tggaggcaac acaggctccc agggtgggaa      300



tcctcctccc agcaccccca tcacagtgac tggacatggc ttggctgttc agagctcaga      360



gcagctcctg catgttatct accagcgggt cgataaggca gtgggtttgg ctgaagctgc      420



tctgggtctt gccagggcca acaatgagtt gttaaaacgt ctccaggagg aagtgggtga      480



cctgaggcaa gggaaagtgt ccatccctga tgaagatggg gaaagccggg cacatagttc      540



cccacctgag gagcctgggc ctctcaagga aagtcccggg gaagccttta aggctctgtc      600



tgccgtggaa gaggagtgtg acagcgtggg cagcggcgtg caggtggtga ttgaggagct      660



gcggcagctg ggagcagcct cagtggggcc tgggcctttg ggcttcccag caactcagag      720



ggacatgcgg ctcccagggt gcacgctggc tgccagcgag gcggcccccc tgctcaatcc      780



tctggtggat gattacgtgg cctctgaggg tgcagtacag cgagttctgg tccctgctta      840



tgccaagcaa ctctcaccag ccacacaact ggcaatccag cgggcaaccc cagagacagg      900



accagaaaat ggaaccaagc tgccaccacc ccgccctgag gacatgctca atgccgctgc      960



tgcgctggac agtgccttgg aagagtcagg ccctgggagc actggggagc tgagacactc     1020



tctagggctg accgtttccc catgcaggac cagaggaagt gggcagaaga actccaggcg     1080



caagcgggat cttgtactct ctaaactggt ccacaatgtg cataaccaca tcaccaatga     1140



caagagattc aatgggtctg aaagcatcaa gtcctcttgg aatatttcag tagtgaagtt     1200



tcttctggaa aagctcaagc aagagctggt gaccagtccc cacaattaca ctgataagga     1260



gctaaaagga gcctgtgtgg cctacttcct tactaagagg cgtgagtacc gcaactccct     1320



gaaccccttt aaaggcctga aggaaaaaga ggagaagaaa cttcgaagtc gccgatatcg     1380



gctttttgcc aaccgatcca gtatcatgag gcattttgga cctgaggacc aacgtctgtg     1440



gaatgatgtg acagaggaac tgatgtcaga tgaagaggac agtcttaacg agccaggtgt     1500



gtgggtggcc cgccctcccc gtttccgggc ccagcgcctc acagagctct gctaccacct     1560



ggatgctaac tctaagcatg gcaccaaagc caaccgtgtg tatgggcctc cctcagacag     1620



actgccttct gctgaagccc agctccttcc accagaactt tacaatccta atttccaaga     1680



agaggaagat gagggagggg atgagaatgc acctggctcc ccatcttttg accaacccca     1740



caaaacctgc tgtcctgact tgaactcatt cattgaaatc aaggtggaaa aggatgaata     1800



aaatctacag ccaagaataa ctctggcttc cgccatgccc catgtctcag aaataggtgg     1860



ccatggggct tcacaaaata atgagatgct ctgtgcagtc tgagaaagca aatttgcctc     1920



ttttcttaac acagtctcta ctggggaagc agaacactgg tgggataaaa acttatctag     1980



aaggggagaa actccctcca ctgtgaacag taagccagaa tatgcttatt cctcagcata     2040



aacagtatct cggagaagcc tgggatgaga aaatgaggag gatgggtcca agaaacatga     2100



ggccttcttg acataaaaaa aaaaaaaaaa aaaa                                 2134





<210>  52

<211>  538

<212>  PRT

<213>  Homo sapiens



<400>  52



Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 

1               5                   10                  15      





Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 

            20                  25                  30          





Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 

        35                  40                  45              





Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 

    50                  55                  60                  





Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 

65                  70                  75                  80  





Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 

                85                  90                  95      





Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 

            100                 105                 110         





Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 

        115                 120                 125             





Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 

    130                 135                 140                 





Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 

145                 150                 155                 160 





Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 

                165                 170                 175     





Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 

            180                 185                 190         





Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 

        195                 200                 205             





Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 

    210                 215                 220                 





Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 

225                 230                 235                 240 





Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 

                245                 250                 255     





Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 

            260                 265                 270         





Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 

        275                 280                 285             





Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 

    290                 295                 300                 





Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 

305                 310                 315                 320 





Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 

                325                 330                 335     





Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 

            340                 345                 350         





His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 

        355                 360                 365             





Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 

    370                 375                 380                 





Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 

385                 390                 395                 400 





Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 

                405                 410                 415     





Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 

            420                 425                 430         





Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg 

        435                 440                 445             





Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys 

    450                 455                 460                 





His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu 

465                 470                 475                 480 





Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn 

                485                 490                 495     





Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser 

            500                 505                 510         





Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser 

        515                 520                 525             





Phe Ile Glu Ile Lys Val Glu Lys Asp Glu 

    530                 535             





<210>  53

<211>  2380

<212>  DNA

<213>  Homo sapiens



<400>  53

gagtcctcct ttttgcacac acacgaatac aaagagccat acgaccttcg gatgccggaa       60



ggtccttctg aatcccttcc ctgttcctta ggttgcacta gtcgggggtt ccatgctggg      120



gggcagaagg aatgctctct accgtctgaa accgttcatc aggaaggcct tgatttgtga      180



tgtgctagga gagcacagga tctgcaaata gaaggcacct gtctcccttc tgcaggccga      240



ggagaggccg ccatggactg tgtgcttctt catggcttgt ttactcttct ttcacagacc      300



ctacagcttg gggcctgggc tcctctgacc atcctcattg agaaaggaaa gtgagtccag      360



agaagttgat gcttcctacc tgttggagcg gcccagcagt gtaagcgtgg ttgttactgc      420



cccatccgcc atgtccttca gtgccaccat tctcttctcc cctcccagtg gcagcgaggc      480



cagatgctgc tgctgcgcct gtaagagtga gactaatgga ggcaacacag gctcccaggg      540



tgggaatcct cctcccagca cccccatcac agtgactgga catggcttgg ctgttcagag      600



ctcagagcag ctcctgcatg ttatctacca gcgggtcgat aaggcagtgg gtttggctga      660



agctgctctg ggtcttgcca gggccaacaa tgagttgtta aaacgtctcc aggaggaagt      720



gggtgacctg aggcaaggga aagtgtccat ccctgatgaa gatggggaaa gccgggcaca      780



tagttcccca cctgaggagc ctgggcctct caaggaaagt cccggggaag cctttaaggc      840



tctgtctgcc gtggaagagg agtgtgacag cgtgggcagc ggcgtgcagg tggtgattga      900



ggagctgcgg cagctgggag cagcctcagt ggggcctggg cctttgggct tcccagcaac      960



tcagagggac atgcggctcc cagggtgcac gctggctgcc agcgaggcgg cccccctgct     1020



caatcctctg gtggatgatt acgtggcctc tgagggtgca gtacagcgag ttctggtccc     1080



tgcttatgcc aagcaactct caccagccac acaactggca atccagcggg caaccccaga     1140



gacaggacca gaaaatggaa ccaagctgcc accaccccgc cctgaggaca tgctcaatgc     1200



cgctgctgcg ctggacagtg ccttggaaga gtcaggccct gggagcactg gggagctgag     1260



acactctcta gggctgaccg tttccccatg caggaccaga ggaagtgggc agaagaactc     1320



caggcgcaag cgggatcttg tactctctaa actggtccac aatgtgcata accacatcac     1380



caatgacaag agattcaatg ggtctgaaag catcaagtcc tcttggaata tttcagtagt     1440



gaagtttctt ctggaaaagc tcaagcaaga gctggtgacc agtccccaca attacactga     1500



taaggagcta aaaggagcct gtgtggccta cttccttact aagaggcgtg agtaccgcaa     1560



ctccctgaac ccctttaaag gcctgaagga aaaagaggag aagaaacttc gaagtcgccg     1620



atatcggctt tttgccaacc gatccagtat catgaggcat tttggacctg aggaccaacg     1680



tctgtggaat gatgtgacag aggaactgat gtcagatgaa gaggacagtc ttaacgagcc     1740



aggtgtgtgg gtggcccgcc ctccccgttt ccgggcccag cgcctcacag agctctgcta     1800



ccacctggat gctaactcta agcatggcac caaagccaac cgtgtgtatg ggcctccctc     1860



agacagactg ccttctgctg aagcccagct ccttccacca gaactttaca atcctaattt     1920



ccaagaagag gaagatgagg gaggggatga gaatgcacct ggctccccat cttttgacca     1980



accccacaaa acctgctgtc ctgacttgaa ctcattcatt gaaatcaagg tggaaaagga     2040



tgaataaaat ctacagccaa gaataactct ggcttccgcc atgccccatg tctcagaaat     2100



aggtggccat ggggcttcac aaaataatga gatgctctgt gcagtctgag aaagcaaatt     2160



tgcctctttt cttaacacag tctctactgg ggaagcagaa cactggtggg ataaaaactt     2220



atctagaagg ggagaaactc cctccactgt gaacagtaag ccagaatatg cttattcctc     2280



agcataaaca gtatctcgga gaagcctggg atgagaaaat gaggaggatg ggtccaagaa     2340



acatgaggcc ttcttgacat aaaaaaaaaa aaaaaaaaaa                           2380





<210>  54

<211>  538

<212>  PRT

<213>  Homo sapiens



<400>  54



Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 

1               5                   10                  15      





Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 

            20                  25                  30          





Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 

        35                  40                  45              





Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 

    50                  55                  60                  





Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 

65                  70                  75                  80  





Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 

                85                  90                  95      





Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 

            100                 105                 110         





Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 

        115                 120                 125             





Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 

    130                 135                 140                 





Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 

145                 150                 155                 160 





Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 

                165                 170                 175     





Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 

            180                 185                 190         





Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 

        195                 200                 205             





Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 

    210                 215                 220                 





Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 

225                 230                 235                 240 





Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 

                245                 250                 255     





Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 

            260                 265                 270         





Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 

        275                 280                 285             





Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 

    290                 295                 300                 





Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 

305                 310                 315                 320 





Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 

                325                 330                 335     





Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 

            340                 345                 350         





His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 

        355                 360                 365             





Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 

    370                 375                 380                 





Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 

385                 390                 395                 400 





Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 

                405                 410                 415     





Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 

            420                 425                 430         





Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg 

        435                 440                 445             





Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys 

    450                 455                 460                 





His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu 

465                 470                 475                 480 





Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn 

                485                 490                 495     





Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser 

            500                 505                 510         





Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser 

        515                 520                 525             





Phe Ile Glu Ile Lys Val Glu Lys Asp Glu 

    530                 535             





<210>  55

<211>  1303

<212>  DNA

<213>  Homo sapiens



<400>  55

gaagagacag cgccgccggc cgtggggagc ggacgcagtg atttgctccc cctcgtgcag       60



caacccccac acccagcacc aggagcctgt tcctctcacg ccctcacctg gctgagccgc      120



agtagttctt cagtggcaag ctttatgtcc tgacccagct aaagctgcca gttgaagaac      180



tgttgccctc tgcccctggc ttcgaggagg aggaggagct gctttcccca tcatctggaa      240



ggtgacagaa atgggctggg aaggtccgaa cagcagggtg gatgatacgt tttgggcaag      300



ttggagagcc tttgcccaga ttggcccagc aaggagcggt tttagattag agacactggc      360



tggattgagg agtagaaggc tcaaacaacc caaggctttc tgcctccgag atgtggcacc      420



atagtgcggt gccctgtggc ttcaccgccc tacttccacc tccgcccagc ctgtaatgtt      480



tatataagca gcctcaagga ccaagaacca tctgcgaaag gacacacaca ggaaattcat      540



aaaagaaatc tgaatggata aaaccatgaa aaaaagtatg cttcattagt aattaaagaa      600



aggcaaatag agctggaagc atttttccct tagcaaacca taacagaaaa aaataagacc      660



caatattggc aaagagacta ctgaaaaaac attcccatac attgcgtgtg ggagtataca      720



tcggtgcagg cttcctggat gacagttggg tgatatgtgt catgtggcct aaaagcctcc      780



atgtcatttg acctacgaat tctatctttg ggaatttatc ctaagaaaat acttaaggat      840



ttagttagtg ataagatgtt catcccagca ttgcaatgga gaaaaatggg aagcaatggt      900



ttggttggga atttattcct tttctgctgt aacgaaagtt tgcaataggg gattgcttaa      960



gtaaattatt gtatctccat ccagatggtg gagtaccgcg cagacattaa aagtcatgta     1020



aaagaacatc tgactgaaag aaaaatgctc cttgaatatt aaaaggttgt aaaaatagtg     1080



catgttatgt gatttcaatt ttgtttttta aaatatgggt gtatgcttgt atacgtagag     1140



cagataaaaa agacggaagg catactaaaa aatgttgagt ggttatcttt gtatggtgga     1200



acaaagtcac tgtaattttc atctttggtt tttctgtaat ttccaaattt tccacatttt     1260



gtatttcata taatataatt taagaaaaaa aaaaaaaaaa aaa                       1303





<210>  56

<211>  57

<212>  PRT

<213>  Homo sapiens



<400>  56



Met Gly Trp Glu Gly Pro Asn Ser Arg Val Asp Asp Thr Phe Trp Ala 

1               5                   10                  15      





Ser Trp Arg Ala Phe Ala Gln Ile Gly Pro Ala Arg Ser Gly Phe Arg 

            20                  25                  30          





Leu Glu Thr Leu Ala Gly Leu Arg Ser Arg Arg Leu Lys Gln Pro Lys 

        35                  40                  45              





Ala Phe Cys Leu Arg Asp Val Ala Pro 

    50                  55          





<210>  57

<211>  1385

<212>  DNA

<213>  Homo sapiens



<400>  57

aagagacagc gccgccggcc gtggggagcg gacgcagtga tttgctcccc ctcgtgcagc       60



aacccccaca cccagcacca ggcccccaga actctccttc cagctgaact ccctgggaac      120



aagtcagttg ggctgatcac tgaactcaca tttctggacc tgaggagcct gttcctctca      180



cgccctcacc tggctgagcc gcagtagttc ttcagtggca agctttatgt cctgacccag      240



ctaaagctgc cagttgaaga actgttgccc tctgcccctg gcttcgagga ggaggaggag      300



ctgctttccc catcatctgg aaggtgacag aaatgggctg ggaaggtccg aacagcaggg      360



tggatgatac gttttgggca agttggagag cctttgccca gattggccca gcaaggagcg      420



gttttagatt agagacactg gctggattga ggagtagaag gctcaaacaa cccaaggctt      480



tctgcctccg agatgtggca ccatagtgcg gtgccctgtg gcttcaccgc cctacttcca      540



cctccgccca gcctgtaatg tttatataag cagcctcaag gaccaagaac catctgcgaa      600



aggacacaca caggaaattc ataaaagaaa tctgaatgga taaaaccatg aaaaaaagta      660



tgcttcatta gtaattaaag aaaggcaaat agagctggaa gcatttttcc cttagcaaac      720



cataacagaa aaaaataaga cccaatattg gcaaagagac tactgaaaaa acattcccat      780



acattgcgtg tgggagtata catcggtgca ggcttcctgg atgacagttg ggtgatatgt      840



gtcatgtggc ctaaaagcct ccatgtcatt tgacctacga attctatctt tgggaattta      900



tcctaagaaa atacttaagg atttagttag tgataagatg ttcatcccag cattgcaatg      960



gagaaaaatg ggaagcaatg gtttggttgg gaatttattc cttttctgct gtaacgaaag     1020



tttgcaatag gggattgctt aagtaaatta ttgtatctcc atccagatgg tggagtaccg     1080



cgcagacatt aaaagtcatg taaaagaaca tctgactgaa agaaaaatgc tccttgaata     1140



ttaaaaggtt gtaaaaatag tgcatgttat gtgatttcaa ttttgttttt taaaatatgg     1200



gtgtatgctt gtatacgtag agcagataaa aaagacggaa ggcatactaa aaaatgttga     1260



gtggttatct ttgtatggtg gaacaaagtc actgtaattt tcatctttgg tttttctgta     1320



atttccaaat tttccacatt ttgtatttca tataatataa tttaagaaaa aaaaaaaaaa     1380



aaaaa                                                                 1385





<210>  58

<211>  57

<212>  PRT

<213>  Homo sapiens



<400>  58



Met Gly Trp Glu Gly Pro Asn Ser Arg Val Asp Asp Thr Phe Trp Ala 

1               5                   10                  15      





Ser Trp Arg Ala Phe Ala Gln Ile Gly Pro Ala Arg Ser Gly Phe Arg 

            20                  25                  30          





Leu Glu Thr Leu Ala Gly Leu Arg Ser Arg Arg Leu Lys Gln Pro Lys 

        35                  40                  45              





Ala Phe Cys Leu Arg Asp Val Ala Pro 

    50                  55          





<210>  59

<211>  5360

<212>  DNA

<213>  Homo sapiens



<400>  59

aagatgcagt tccacctccc agattcccta gttactatct ctaagcactg aagtcggtgt       60



ttggagaaaa ggactcaggt gaggactgga gcctaacaga tgagacagaa tataaacagg      120



aagtctctaa ggcagtgtgg tggaaggata ataccatgat ggaggaagtg cacagtatta      180



tgggagaaca tagcagtggc atctgaccaa ttttaaggga atccaggaca gctttcctga      240



agctgaagaa agagtaaaag ccaggcttat caaagttttg gctttgttgc aagagcaggt      300



caagatttag ctgttcttca gtgaacaagt gtgcagattg tcaaatatgt cagttcatca      360



aataagaaaa catgcagttc tcccacctat catttgtaga agtgacaagg aatttttgga      420



aagtgtgcaa agatacataa ttacagaaac tgaaagactg ggctgtagtg aggaaggacc      480



tgctgatgaa tattacatca tataccgaaa tgtttttgat aaggtaatag agcatatcac      540



tgcatacaaa tccattctta cttcaatcaa aaaagaatat gatgccttta ttgagacaat      600



aaagaaagac cgaagaacta cattttgtct tcatggaaaa cttaaaggtt tggcagcaga      660



gcctacagct ttggtatatt acaggaaaag aacaatccaa cttgaagcaa aaatgaggat      720



tatcgaaagt aattcctcga agattcaatc tcaaatagat cacatcaagc agtgtagggc      780



agagtatgac acaaaagaag taaaatattg tactttctcc aaagatcctt caaaacctat      840



tccaggcatg actcttcaag aatccatgaa tctagatgct ctcactaaat acatgaaaca      900



tcttgaagat aaatatgcag aaattaaaca agctatgttg ataaaatatg tgccagctca      960



gaggaaggct gatttagatg aagaaatgat tgtgttatta aaacggcgag atgtagctga     1020



aaatctgaac aaaaaattgc agttttgtca tcaaagactg cagataattt cacaggcact     1080



tagttcatgg gtaaaatctg atatgagcag cccatttcaa gactttgtgg agcaaattca     1140



gaaaaccaaa tatttacaag gtgaccaagg cattgttgaa gaactaatgg aagatgatcc     1200



acgcagggca aaagaagctg aaattatgct tcactacatt gaaaggttta atgagttaat     1260



ctcacttggt gaatatgaaa aggcagcttg ttatgcagca aacagtccta gaagaattct     1320



tcgaaacatt ggtacaatga atacatttaa ggctgttgga aaaattagag gaaagcctct     1380



tccattactc ttattttttg aggccctctt tatcacaagt catgcttttc catgtcctgt     1440



tgatgcagct ctaaccctgg aaggaatcaa atgtggatta tcagaaaaac ggttagattt     1500



agttaccaat tgggttacac aggaaagact gacattttct gaggaggctg gggatgtgat     1560



ttgtgattat ggggagcagg atacttataa caaggccaag tgcctggctt tagctcagat     1620



tgtctacagt gaatgtggcc tgcacaagaa agctattctt tgcttgtgta aacagggtca     1680



gactcatagg gtcatggagt acatacagca gttgaaggac tttactaccg atgacctgtt     1740



gcagctatta atgtcatgtc cccaagttga attaattcag tgtctcacta aagagttgaa     1800



tgagaaacaa ccatctttat cttttggtct tgctatactt catctgttct ctgcagacat     1860



gaaaaaagtt ggcattaagc tacttcaaga aatcaataaa ggtgggatag atgcagtaga     1920



aagtcttatg ataaatgatt ccttttgctc catagaaaag tggcaagaag tggcaaatat     1980



atgttcacag aatggctttg acaaattatc taatgacatc acgtctattc ttcgatctca     2040



ggctgcagtt acagaaattt ctgaagagga tgacgcagtc aacctaatgg aacatgtgtt     2100



ttggtagttc tatatcttaa ccagctgagg gagcttgtac aacaccttat gtatgctggt     2160



tgggaaaaac tgattttaac gtaactaact tataaataaa tctagagtaa gaagatctca     2220



gaaataaatc acacttttgt tatgatgaca tttagatttg tctttgaaat atttatacta     2280



ttgcttcctt ttccccatat ggtcatttct tatattgaat cttgataaaa tccaagatta     2340



taactttgtg tgaaacagtg tagggcattt ttatctaagg acataagcta atgtccagat     2400



atattacttt ctggtgatgt aatatgatag caagaactga ggaaggtgtg ggtagtatcc     2460



tgtgtgttag actgtcttcc caaacatgaa atgctacaag cctgacttga ccagaaaagc     2520



aggaaatcat ttcaaggttg gacttgctgg caaaaaccta gagtatagta attttgtact     2580



gctgatttaa agatgcgccc catgctttga tatatataaa tatggcaaag cttaggcttc     2640



tagtataaaa gctgggactc ttggcatgtt attacttaga gagaagacca gtcgaatttt     2700



gcatagaagt agacctgtga tacctatagg tatggaaaat atgtcataag aagtggtttt     2760



ggattatttc aagtgtctga ataagtattt gattgaaaac tctgaaagtt ctgtgccatg     2820



gacaggtgta atattaaaaa tatttaatga ttagtatggc atgggcacaa atcaagcaga     2880



acagatacct aattaatcag aacagccttt agcccttatg ccacaccaga gcttactagc     2940



taaatgtcat ccttgaccat ggaacatggt taaaatgagc tgctggctgg gcaaggtagc     3000



tcatgtctgt aatcccagca ctttgggagg tcgaggcagg aggatcgctt gagcccagga     3060



gtttgagacc agctaggtaa cacagtgaga tcccgtctct gttattaaaa aaagaaaaaa     3120



aaatttcaag taaaaaatga aaatgatctg ctattagaat aagagcaaag agcataactt     3180



ttcccatcct aaatttaaat tgaatatgta tttttatgtt atagtggaaa gaagatgaac     3240



ggggagtcag acagcttcat attaaaattc tggtcctacc tcttactcac ttataaaata     3300



tgggcagtct tccttaggct tgttgtgagg attagtgata atgtatgtgt agtgtaagtg     3360



tataacatga tagaggaact taggaaaaga tagctgtaat tcctttgtaa tcggccccag     3420



aaacacacat ttctctactt agtttgtact tactaaatcc catatgtcta ctcatttgta     3480



tttatatgtt tatccttctt taaagtattt gatatattgg tacaacttat tgctgagatt     3540



aagttatctg tccacacttg tattagggtt gcctggctta tcttataaat tcagaagcat     3600



tcaagctgag tttttaattt ttccatttgg tgctaaatag aatactggat aattataatt     3660



cagctttcta aaacgtagca tttttaaagt aatacatgtg catagtttaa aaagcaattt     3720



attactaaaa gccttatcaa aataatattt tgatttttgg ccttcataca ggctgttgaa     3780



aagagcagat aaaggatgga aaaaaggaat ggaaagggag aggtatttcg gcagcactgg     3840



ttctttgtgt gccaacggct taaaaccttt tttttttttt ttttcctttg agacctatat     3900



gattgataga aagctattat gtgtccattg acagagctta gaaaaaaaaa tgtcttcatg     3960



aaagccagga ggataaagta ggtatataaa tctagagaaa gcttaaacag cggttgttgt     4020



tgttattcta attttgcctt gtttttcctt ttctcattat tactccttct cagttagcat     4080



tgcctttggc agctttccca aggaaagtaa aagttgtcaa gtgaatataa attaaaatgc     4140



ctggtgatgg aaaatggagt tgggaggaag agcaagatta caaagttaaa tgaggaagga     4200



gaaagaattg agttgtgagc tacagagggc tttgaagcta taagagcctc catgtaagct     4260



acactgaagg aggtataatc tgggcctcag cacagaaacc tgcattctag accagcccca     4320



ccactgtcta gctatgtgtc cttttcctca tgcttaagat aaatttattt tgactagata     4380



cctcctcttg tcatttccaa ctctaaaatt cagtaattct gaaaaggtac aaattatttc     4440



ccaatgcttc ttgaccttca gcctaaattt caaatactac aattcaacat cagcatcaac     4500



aacatctacc gaatacctgt tttgcacaca atttctgcta gcaagattac aaccttaatg     4560



gaaacacaca acgtatttta aaagttacta ataataattc cttagcatta tctaatagcc     4620



agtccatatt caaatttcac cagttgctaa aaatgccttt taacatttga attgttccaa     4680



tgaagattta accaacgttc atgtgttcta ttaggtcttg ctgtcttgag cgtgtcttct     4740



ctcctttttt cctcttgcca ttgattgctt tacatagcag ttgcaaagca agggtcatga     4800



tgaactaagt ttctctgatt tcatattagg ttttctttct accataccag tgaggaaagg     4860



aagatatttc ttccaaggtc tgaaagattt aattgtaact agttacattt ttgtttatta     4920



tagtcaagca tgtatcaaaa tgaatttcta ttaaattcat tcatttggaa aggtttagag     4980



atgttgaaca gaagtctagt ctaatgaaaa aaattttttt aatatttaga acttttccta     5040



aatcctgaat taactaagaa atgaccatta aattaatcac ttttttaact ttaaaaggtg     5100



aaaacctgtt actttttagg tgcctggaat tctgttggat tgctaaagca tatgttaagt     5160



caaaaatcat agcagaggcc tttttttttt tttttaactt tgtacatttc atagaaagct     5220



catacatttc ttccattctt tctcagaaaa aaatggcatt taacaaatgt tcggtgtata     5280



aagctgtcag tttgctagta gttataattt gttgtgttct tgaataaaaa tatattgggt     5340



acataaaaaa aaaaaaaaaa                                                 5360





<210>  60

<211>  586

<212>  PRT

<213>  Homo sapiens



<400>  60



Met Ser Val His Gln Ile Arg Lys His Ala Val Leu Pro Pro Ile Ile 

1               5                   10                  15      





Cys Arg Ser Asp Lys Glu Phe Leu Glu Ser Val Gln Arg Tyr Ile Ile 

            20                  25                  30          





Thr Glu Thr Glu Arg Leu Gly Cys Ser Glu Glu Gly Pro Ala Asp Glu 

        35                  40                  45              





Tyr Tyr Ile Ile Tyr Arg Asn Val Phe Asp Lys Val Ile Glu His Ile 

    50                  55                  60                  





Thr Ala Tyr Lys Ser Ile Leu Thr Ser Ile Lys Lys Glu Tyr Asp Ala 

65                  70                  75                  80  





Phe Ile Glu Thr Ile Lys Lys Asp Arg Arg Thr Thr Phe Cys Leu His 

                85                  90                  95      





Gly Lys Leu Lys Gly Leu Ala Ala Glu Pro Thr Ala Leu Val Tyr Tyr 

            100                 105                 110         





Arg Lys Arg Thr Ile Gln Leu Glu Ala Lys Met Arg Ile Ile Glu Ser 

        115                 120                 125             





Asn Ser Ser Lys Ile Gln Ser Gln Ile Asp His Ile Lys Gln Cys Arg 

    130                 135                 140                 





Ala Glu Tyr Asp Thr Lys Glu Val Lys Tyr Cys Thr Phe Ser Lys Asp 

145                 150                 155                 160 





Pro Ser Lys Pro Ile Pro Gly Met Thr Leu Gln Glu Ser Met Asn Leu 

                165                 170                 175     





Asp Ala Leu Thr Lys Tyr Met Lys His Leu Glu Asp Lys Tyr Ala Glu 

            180                 185                 190         





Ile Lys Gln Ala Met Leu Ile Lys Tyr Val Pro Ala Gln Arg Lys Ala 

        195                 200                 205             





Asp Leu Asp Glu Glu Met Ile Val Leu Leu Lys Arg Arg Asp Val Ala 

    210                 215                 220                 





Glu Asn Leu Asn Lys Lys Leu Gln Phe Cys His Gln Arg Leu Gln Ile 

225                 230                 235                 240 





Ile Ser Gln Ala Leu Ser Ser Trp Val Lys Ser Asp Met Ser Ser Pro 

                245                 250                 255     





Phe Gln Asp Phe Val Glu Gln Ile Gln Lys Thr Lys Tyr Leu Gln Gly 

            260                 265                 270         





Asp Gln Gly Ile Val Glu Glu Leu Met Glu Asp Asp Pro Arg Arg Ala 

        275                 280                 285             





Lys Glu Ala Glu Ile Met Leu His Tyr Ile Glu Arg Phe Asn Glu Leu 

    290                 295                 300                 





Ile Ser Leu Gly Glu Tyr Glu Lys Ala Ala Cys Tyr Ala Ala Asn Ser 

305                 310                 315                 320 





Pro Arg Arg Ile Leu Arg Asn Ile Gly Thr Met Asn Thr Phe Lys Ala 

                325                 330                 335     





Val Gly Lys Ile Arg Gly Lys Pro Leu Pro Leu Leu Leu Phe Phe Glu 

            340                 345                 350         





Ala Leu Phe Ile Thr Ser His Ala Phe Pro Cys Pro Val Asp Ala Ala 

        355                 360                 365             





Leu Thr Leu Glu Gly Ile Lys Cys Gly Leu Ser Glu Lys Arg Leu Asp 

    370                 375                 380                 





Leu Val Thr Asn Trp Val Thr Gln Glu Arg Leu Thr Phe Ser Glu Glu 

385                 390                 395                 400 





Ala Gly Asp Val Ile Cys Asp Tyr Gly Glu Gln Asp Thr Tyr Asn Lys 

                405                 410                 415     





Ala Lys Cys Leu Ala Leu Ala Gln Ile Val Tyr Ser Glu Cys Gly Leu 

            420                 425                 430         





His Lys Lys Ala Ile Leu Cys Leu Cys Lys Gln Gly Gln Thr His Arg 

        435                 440                 445             





Val Met Glu Tyr Ile Gln Gln Leu Lys Asp Phe Thr Thr Asp Asp Leu 

    450                 455                 460                 





Leu Gln Leu Leu Met Ser Cys Pro Gln Val Glu Leu Ile Gln Cys Leu 

465                 470                 475                 480 





Thr Lys Glu Leu Asn Glu Lys Gln Pro Ser Leu Ser Phe Gly Leu Ala 

                485                 490                 495     





Ile Leu His Leu Phe Ser Ala Asp Met Lys Lys Val Gly Ile Lys Leu 

            500                 505                 510         





Leu Gln Glu Ile Asn Lys Gly Gly Ile Asp Ala Val Glu Ser Leu Met 

        515                 520                 525             





Ile Asn Asp Ser Phe Cys Ser Ile Glu Lys Trp Gln Glu Val Ala Asn 

    530                 535                 540                 





Ile Cys Ser Gln Asn Gly Phe Asp Lys Leu Ser Asn Asp Ile Thr Ser 

545                 550                 555                 560 





Ile Leu Arg Ser Gln Ala Ala Val Thr Glu Ile Ser Glu Glu Asp Asp 

                565                 570                 575     





Ala Val Asn Leu Met Glu His Val Phe Trp 

            580                 585     





<210>  61

<211>  1279

<212>  DNA

<213>  Homo sapiens



<400>  61

ctttcagttg ctttgctgtt agcctgttgg accttcgagc ctagctgctc gcacaggact       60



cggccacctg cccttcctgc accgactggc cagctcaaga ggtttggata tggaccttct      120



tcaattcctg gccttcctct ttgtcctgct tttgtctggg atgggagcca caggcacctt      180



gaggacctcc ctggacccaa gcctggagat ctacaagaag atgtttgagg tgaagcggcg      240



ggagcagctg ttggcactga agaacctggc acagctgaac gacatccacc agcagtacaa      300



gatccttgat gtcatgctca aggggctctt taaggtgctg gaggactccc ggacagtgct      360



caccgctgct gatgtgctcc cagatgggcc cttcccccag gacgagaagc tgaaggatgc      420



tttctcccac gtggtggaga acacggcctt cttcggcgat gtggtgctgc gcttcccgag      480



gattgtgcac tattactttg accacaactc caactggaac ctcctcatcc gctggggtat      540



cagtttctgc aaccagacag gcgtcttcaa ccaggggccc cactcgccca tcctcagcct      600



gatggcccag gagctgggga tcagtgagaa agactccaac ttccagaacc catttaaaat      660



cgaccgcaca gagttcattc ccagcactga ccctttccag aaggccctga gagaagaaga      720



gaaacgccga aagaaagagg agaagcggaa ggagatccga aaaggcccaa ggatctccag      780



atcccagtct gagttatagc cctggagcag ctcagggctc agggggccac aaggaggcag      840



gtcgggagga agaagaggtg gaggtgtggt tgtggtggag agcaccagct agccccttcc      900



agaaggggag gccacatttg cccggccccc tggagctggg tctgagcccc agctgaaggg      960



actgagcctc agatggctgg attttctctc aggggcctcc tgctgaaggg gccttcagag     1020



gattttatgc tggaaatatg accctgtgca gactgctggg ggaggcagga ggatgcctgc     1080



ctggaccctg ttggtggctg aagacctctg gccagctggc ttccgccctt ggtggggaag     1140



cagcagaact aggttctgag ccacgggtca gggtgccacc ctgctgctgg ccccactgtg     1200



tcacagagct gcctggcaca ggtcccagcc cctctgcaga gacacaataa aagccagcag     1260



accctttgga ccgacaaaa                                                  1279





<210>  62

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  62



Met Asp Leu Leu Gln Phe Leu Ala Phe Leu Phe Val Leu Leu Leu Ser 

1               5                   10                  15      





Gly Met Gly Ala Thr Gly Thr Leu Arg Thr Ser Leu Asp Pro Ser Leu 

            20                  25                  30          





Glu Ile Tyr Lys Lys Met Phe Glu Val Lys Arg Arg Glu Gln Leu Leu 

        35                  40                  45              





Ala Leu Lys Asn Leu Ala Gln Leu Asn Asp Ile His Gln Gln Tyr Lys 

    50                  55                  60                  





Ile Leu Asp Val Met Leu Lys Gly Leu Phe Lys Val Leu Glu Asp Ser 

65                  70                  75                  80  





Arg Thr Val Leu Thr Ala Ala Asp Val Leu Pro Asp Gly Pro Phe Pro 

                85                  90                  95      





Gln Asp Glu Lys Leu Lys Asp Ala Phe Ser His Val Val Glu Asn Thr 

            100                 105                 110         





Ala Phe Phe Gly Asp Val Val Leu Arg Phe Pro Arg Ile Val His Tyr 

        115                 120                 125             





Tyr Phe Asp His Asn Ser Asn Trp Asn Leu Leu Ile Arg Trp Gly Ile 

    130                 135                 140                 





Ser Phe Cys Asn Gln Thr Gly Val Phe Asn Gln Gly Pro His Ser Pro 

145                 150                 155                 160 





Ile Leu Ser Leu Met Ala Gln Glu Leu Gly Ile Ser Glu Lys Asp Ser 

                165                 170                 175     





Asn Phe Gln Asn Pro Phe Lys Ile Asp Arg Thr Glu Phe Ile Pro Ser 

            180                 185                 190         





Thr Asp Pro Phe Gln Lys Ala Leu Arg Glu Glu Glu Lys Arg Arg Lys 

        195                 200                 205             





Lys Glu Glu Lys Arg Lys Glu Ile Arg Lys Gly Pro Arg Ile Ser Arg 

    210                 215                 220                 





Ser Gln Ser Glu Leu 

225                 





<210>  63

<211>  2811

<212>  DNA

<213>  Homo sapiens



<400>  63

ccatttcaat agtcgcggga tacttgaact gcaagaacag ccgccgctcc ggcgggctgc       60



tcgctgcatc tctgggcgtc tttggctcgc cacgctgggc agtgcctgcc tgcgcctttc      120



gcaacctcct cggccctgcg tggtctcgag ctgggtgagc gagcgggcgg gctggtaggc      180



tggcctgggc tgcgaccggc ggctacgact attctttggc cgggtcggtg cgagtggtcg      240



gctgggcaga gtgcacgctg cttggcgccg caggctgatc ccgccgtcca ctcccgggag      300



cagtgatgtt gggcaactct gcgccggggc ctgcgacccg cgaggcgggc tcggcgctgc      360



tagcattgca gcagacggcg ctccaagagg accaggagaa tatcaacccg gaaaaggcag      420



cgcccgtcca acaaccgcgg acccgggccg cgctggcggt actgaagtcc gggaacccgc      480



ggggtctagc gcagcagcag aggccgaaga cgagacgggt tgcacccctt aaggatcttc      540



ctgtaaatga tgagcatgtc accgttcctc cttggaaagc aaacagtaaa cagcctgcgt      600



tcaccattca tgtggatgaa gcagaaaaag aagctcagaa gaagccagct gaatctcaaa      660



aaatagagcg tgaagatgcc ctggctttta attcagccat tagtttacct ggacccagaa      720



aaccattggt ccctcttgat tatccaatgg atggtagttt tgagtcacca catactatgg      780



acatgtcaat tgtattagaa gatgaaaagc cagtgagtgt taatgaagta ccagactacc      840



atgaggatat tcacacatac cttagggaaa tggaggttaa atgtaaacct aaagtgggtt      900



acatgaagaa acagccagac atcactaaca gtatgagagc tatcctcgtg gactggttag      960



ttgaagtagg agaagaatat aaactacaga atgagaccct gcatttggct gtgaactaca     1020



ttgataggtt cctgtcttcc atgtcagtgc tgagaggaaa acttcagctt gtgggcactg     1080



ctgctatgct gttagcctca aagtttgaag aaatataccc cccagaagta gcagagtttg     1140



tgtacattac agatgatacc tacaccaaga aacaagttct gagaatggag catctagttt     1200



tgaaagtcct tacttttgac ttagctgctc caacagtaaa tcagtttctt acccaatact     1260



ttctgcatca gcagcctgca aactgcaaag ttgaaagttt agcaatgttt ttgggagaat     1320



taagtttgat agatgctgac ccatacctca agtatttgcc atcagttatt gctggagctg     1380



cctttcattt agcactctac acagtcacgg gacaaagctg gcctgaatca ttaatacgaa     1440



agactggata taccctggaa agtcttaagc cttgtctcat ggaccttcac cagacctacc     1500



tcaaagcacc acagcatgca caacagtcaa taagagaaaa gtacaaaaat tcaaagtatc     1560



atggtgtttc tctcctcaac ccaccagaga cactaaatct gtaacaatga aagactgcct     1620



ttgttttcta agatgtaaat cactcaaagt atatggtgta cagtttttaa cttaggtttt     1680



aattttacaa tcatttctga atacagaagt tgtggccaag tacaaattat ggtatctatt     1740



actttttaaa tggttttaat ttgtatatct tttgtatatg tatctgtctt agatatttgg     1800



ctaattttaa gtggttttgt taaagtatta atgatgccag ctgtcaggat aataaattga     1860



tttggaaaac tttgcaagtc aaatttaact tcttcaggat tttgcttagt aaagaagttt     1920



acttggttta ctatataatg ggaagtgaaa agccttcctc taaaattaaa gtaggtttag     1980



gaaaacagac cctcaaattc tgacattcat tttcctaagc aactggatca atttgctgac     2040



ttgggcataa tctaatctaa gcatatctga atacagtatt cagagataga tacagtagag     2100



attccccaga ctttttcgct ctttgtaaaa cctgtttgtt taggttttgc gaggtaaact     2160



caacagaggt tgggagtgga agagggtggg aagcttatat gcaaattaac agacgagaaa     2220



tgctccagaa ggtttattat tttaaagcac attaaaaaca aaaaactatt tttaaaatcc     2280



tgctagattt tataatggat ttgtgaataa aaaataccca gggttctcag aatggaataa     2340



atatcccttt taatagttat atatacagat atacaactgt tagctttaat tggcagctct     2400



cttctttttt cttcttttca ctggcttttt acttggtgct ttttcttgtt ttgcactggt     2460



ggtctgtgtt ctgtgaataa agcaaagtaa gaatttacta agagtatgtt aagttttgga     2520



ttattgaaat aagaggcatt tcttagtttt ccagtaggat ctaaaatgtg tcagctatga     2580



gtaagactgg catccaagaa gtttatatta tagatttagg tcctaatttt tataaatcac     2640



aaggtaaaaa aatcacagaa cagatggatc tctaatgaaa aagggatgtc tttttgttta     2700



tagtcatgtg gcaagatgag agtaaaacca gagagcaaac ctctataagt gttgagtata     2760



tgtatacatt tgaaataaac cagaaatttg ttaccttaaa aaaaaaaaaa a              2811





<210>  64

<211>  432

<212>  PRT

<213>  Homo sapiens



<400>  64



Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 

1               5                   10                  15      





Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn 

            20                  25                  30          





Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 

        35                  40                  45              





Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 

    50                  55                  60                  





Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 

65                  70                  75                  80  





Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 

                85                  90                  95      





Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 

            100                 105                 110         





Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 

        115                 120                 125             





Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 

    130                 135                 140                 





Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 

145                 150                 155                 160 





Ser Ile Val Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 

                165                 170                 175     





Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 

            180                 185                 190         





Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 

        195                 200                 205             





Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 

    210                 215                 220                 





Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile Asp 

225                 230                 235                 240 





Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 

                245                 250                 255     





Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 

            260                 265                 270         





Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 

        275                 280                 285             





Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr Phe 

    290                 295                 300                 





Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 

305                 310                 315                 320 





His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 

                325                 330                 335     





Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 

            340                 345                 350         





Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 

        355                 360                 365             





Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 

    370                 375                 380                 





Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 

385                 390                 395                 400 





Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 

                405                 410                 415     





Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 

            420                 425                 430         





<210>  65

<211>  913

<212>  DNA

<213>  Homo sapiens



<400>  65

ccagagaggg gcaggctggt cccctgacag gttgaagcaa gtagacgccc aggagccccg       60



ggagggggct gcagtttcct tccttccttc tcggcagcgc tccgcgcccc catcgcccct      120



cctgcgctag cggaggtgat cgccgcggcg atgccggagg agggttcggg ctgctcggtg      180



cggcgcaggc cctatgggtg cgtcctgcgg gctgctttgg tcccattggt cgcgggcttg      240



gtgatctgcc tcgtggtgtg catccagcgc ttcgcacagg ctcagcagca gctgccgctc      300



gagtcacttg ggtgggacgt agctgagctg cagctgaatc acacaggacc tcagcaggac      360



cccaggctat actggcaggg gggcccagca ctgggccgct ccttcctgca tggaccagag      420



ctggacaagg ggcagctacg tatccatcgt gatggcatct acatggtaca catccaggtg      480



acgctggcca tctgctcctc cacgacggcc tccaggcacc accccaccac cctggccgtg      540



ggaatctgct ctcccgcctc ccgtagcatc agcctgctgc gtctcagctt ccaccaaggt      600



tgtaccattg cctcccagcg cctgacgccc ctggcccgag gggacacact ctgcaccaac      660



ctcactggga cacttttgcc ttcccgaaac actgatgaga ccttctttgg agtgcagtgg      720



gtgcgcccct gaccactgct gctgattagg gttttttaaa ttttatttta ttttatttaa      780



gttcaagaga aaaagtgtac acacaggggc cacccggggt tggggtggga gtgtggtggg      840



gcgtagtggt ggcaggacaa gagaaggcat tgagcttttt ctttcatttt cctattaaaa      900



aatacaaaaa tca                                                         913





<210>  66

<211>  193

<212>  PRT

<213>  Homo sapiens



<400>  66



Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 

1               5                   10                  15      





Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 

            20                  25                  30          





Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 

        35                  40                  45              





Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 

    50                  55                  60                  





Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 

65                  70                  75                  80  





Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 

                85                  90                  95      





Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 

            100                 105                 110         





Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 

        115                 120                 125             





Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 

    130                 135                 140                 





Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 

145                 150                 155                 160 





Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 

                165                 170                 175     





Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 

            180                 185                 190         





Pro 

    





<210>  67

<211>  6910

<212>  DNA

<213>  Homo sapiens



<400>  67

gggcaagctg gaaaagcgtg tgggtgagac cctcgcacaa ccccttttca ttgtctgtgt       60



gtggcgcctg cgcagtaagg gatcgttgga actgggcagg aggggatagg gtccggctcc      120



tcgccctttc ccgaggcgcc tgcgcactag gcagtcggtc tttgccgtta ccgctatgtg      180



tggggcgtgt gtggaataac gttattgccc agcggagctg agggccccgg agctcgaccg      240



cagcggcagc gacgacaaca gcggcgacga cgacgacgac gaggtggggg gaggacggcg      300



tgcgagagac tcacgggacg cgacgcgccc cgcctccccc gtccggtccc tctctccacg      360



gtaaggggat gacgtagctt tgccaaagac ttagaagcta agcagaaaat gagcttaaca      420



tcctggtttt tggtgagcag tggaggcact cgccacaggc tgccacgaga aatgattttt      480



gttggaagag atgactgtga gctcatgttg cagtctcgta gtgtggataa gcaacacgct      540



gtcatcaact atgatgcgtc tacggatgag catttagtga aggatttggg cagcctcaat      600



gggacttttg tgaatgatgt aaggattccg gaacagactt atatcacctt gaaacttgaa      660



gataagctga gatttggata tgatacaaat cttttcactg tagtacaagg agaaatgagg      720



gtccctgaag aagctcttaa gcatgagaag tttaccattc agcttcagtt gtcccaaaaa      780



tcttcagaat cagaattatc caaatctgca agtgccaaaa gcatagattc aaaggtagca      840



gacgctgcta ctgaagtgca gcacaaaact actgaagcac tgaaatccga ggaaaaagcc      900



atggatattt ctgctatgcc ccgtggtact ccattatatg ggcagccgtc atggtggggg      960



gatgatgagg tggatgaaaa aagagctttc aagacaaatg gcaaacctga agaaaaaaac     1020



catgaagctg gaacatcagg gtgcggcata gatgccaagc aagttgagga acaatctgca     1080



gctgcaaatg aagaagtact ttttcctttc tgtagggaac caagttattt tgaaatccct     1140



acaaaagaat tccagcaacc atcacaaata acagaaagca ctattcatga aatcccaaca     1200



aaagacacgc caagttccca tataacaggt gcagggcatg cttcatttac cattgaattt     1260



gatgacagta ccccagggaa ggtaactatt agagaccatg tgacaaagtt tacttctgat     1320



cagcgccaca agtccaagaa gtcttctcct ggaactcaag acttgctggg gattcaaaca     1380



ggaatgatgg cacccgaaaa caaagttgct gactggctag cacaaaacaa ccctcctcaa     1440



atgctatggg aaagaacaga agaggattct aaaagcatta aaagtgatgt tccagtgtac     1500



ttgaaaaggt tgaaaggaaa taaacatgat gatggtacgc aaagtgattc agagaacgct     1560



ggggctcaca ggcgctgtag caaacgtgca actcttgagg aacacttaag acgccaccat     1620



tcagaacaca aaaagctaca gaaggtccag gctactgaaa agcatcaaga ccaagctgtt     1680



gtgtttggag tagatgacaa tcaggattat aataggcctg ttatcaacga aaaacataaa     1740



gatctaataa aagattgggc tctcagttct gctgcagcag taatggaaga aagaaaacca     1800



ctgactacat ctggatttca ccactcagag gaaggcacat cttcatctgg aagcaaacgt     1860



tgggtttcac agtgggctag tttggctgcc aatcatacaa ggcatgatca agaagaaagg     1920



ataatggaat tttctgcacc tcttccttta gagaatgaga cagagatcag tgagtctggc     1980



atgacagtga gaagtactgg ctctgcaact tccttggcta gccagggaga gagaaggaga     2040



cgaactcttc cccagcttcc aaatgaagaa aagtctcttg agagccacag agcaaaggtt     2100



gtaacacaga ggtcagagat aggagaaaaa caagacacag aacttcagga gaaagaaaca     2160



cctacacagg tataccagaa agataaacaa gatgctgaca gacccttgag taaaatgaac     2220



agggcagtaa atggagagac tctcaaaact ggtggagata ataaaaccct acttcactta     2280



ggcagctctg ctcctggaaa agagaaaagt gaaactgata aggaaacttc tttggtaaag     2340



caaacattag caaaacttca acaacaagaa caaagggagg aggctcagtg gacacctact     2400



aaattgtctt ccaaaaatgt ttcaggtcag acagataaat gtagggagga aacttttaaa     2460



caagaatcac aacctccaga aaaaaattca ggacattcta caagcaaagg agacagagtg     2520



gcacaaagtg agagcaagag aagaaaagct gaggaaattc tgaaaagtca gactccaaag     2580



ggaggagaca agaaggaatc ctccaagtca ttagtgcgac aagggagctt cactatagaa     2640



aaacccagcc caaacatacc catagaactt attccccata taaataaaca gacttcctct     2700



actccttctt ctttagcatt aacatctgca agtagaatac gagaaagaag tgagtctttg     2760



gatcctgatt ctagtatgga cacaaccctt attctaaaag acacagaagc agtaatggct     2820



tttctagaag ctaaactacg tgaagataat aaaactgatg aaggaccaga tactcccagt     2880



tataatagag acaattctat ttcaccagaa tctgatgtag atacagctag tacaatcagt     2940



ctggttactg gagaaactga aagaaagtca acccaaaagc gaaagagttt cactagcctc     3000



tataaagata ggtgttccac aggttctcct tccaaagatg ttacaaaatc atcatcttca     3060



ggtgctaggg aaaaaatgga aaagaaaaca aaaagtcgtt ccacagatgt gggttcaaga     3120



gcagatggtc gtaaatttgt tcagtccagt gggagaataa gacagccctc agtagactta     3180



acagatgatg accaaacctc tagtgtacct cattctgcca tctctgatat tatgtcatct     3240



gatcaagaaa cttactcttg taaacctcat ggacggactc cacttacctc agctgatgag     3300



catgtacatt ccaaactgga aggaagtaaa gtaacgaaat ctaagacttc tccggtggta     3360



tctggttcat ctagtaaatc aaccaccctt ccaaggccac gacctaccag gacttccctc     3420



ttgcgcagag cacgacttgg tgaagcttca gacagtgaac ttgctgatgc tgacaaagca     3480



tctgttgctt ctgaagtatc cacaacaagt tctacatcaa aacctcccac aggaaggcgt     3540



aacatctctc ggattgattt attggctcag cctcgtagaa cacgacttgg ctcactgtca     3600



gctcgtagtg actctgaagc aacaatttct agaagtagtg cctcttcgag gaccgcagaa     3660



gccatcatta gaagtggagc cagactagta ccatcagata aattttctcc tagaattaga     3720



gctaacagta tctctcgact ctcagactcc aaggtcaaaa gtatgacctc agctcatggc     3780



tctgcttcag taaattcaag atggaggcgc tttcctactg attatgcttc cacctcagaa     3840



gatgaatttg gatcaaaccg taattcccct aaacataccc gtctacgtac ttctccagcc     3900



ctgaaaacca ctcgcttgca gagcgctgga tcagcaatgc ctactagttc ttcattcaaa     3960



caccggatta aagagcagga agactacatc cgagattgga ctgctcatcg agaagagata     4020



gccaggatca gccaagatct tgctctcatt gctcgggaga tcaacgatgt agcaggagag     4080



atagattcag tgacttcatc aggcactgcc cctagtacca cagtaagcac tgctgccacc     4140



acccctggct ctgccataga cactagagaa gagttggttg atcgtgtttt tgatgaaagc     4200



ctcaacttcc gaaagattcc tccattagtt cattccaaaa caccagaagg aaacaacggt     4260



cgatctggtg atccaagacc tcaagcagca gagcctcccg atcacttaac aattacaagg     4320



cggagaacct ggagcaggga tgaagtcatg ggagataatc tgctgctgtc atccgtcttt     4380



cagttctcta agaagataag acaatctata gataagacag ctggaaagat cagaatatta     4440



tttaaagaca aagatcggaa ttgggatgac atagaaagca aattaagagc cgaaagtgaa     4500



gtccctattg tgaaaacctc aagcatggag atttcttcta tcttacagga actgaaaaga     4560



gtagaaaagc agctgcaagc aatcaatgct atgattgatc ctgatggaac tttggaggct     4620



ctgaacaaca tgggatttcc cagtgctatg ttgccatctc caccgaaaca gaagtccagc     4680



cctgtgaata accaccacag cccgggtcag acaccaacac ttggccaacc agaagctagg     4740



gctcttcatc ctgctgctgt ttcagccgca gctgaatttg agaatgctga atctgaggct     4800



gatttcagta tacatttcaa tagattcaac cccgatgggg aagaggaaga tgttacagta     4860



caagaatgac tttctcttga ttgttgaaaa atcattacct gtggaatggc taggaatatt     4920



ggaagcagca tagtgttgat gtacgcaaaa caagacagct tggtcagcta caatcttgga     4980



atccctgtct tcttaatttt atttatttat ttttgacgta taatgtagta tatcaatcct     5040



ttcaaactat ttagataacc acttgatgca caaataggaa aaagcagatt gtggcagtgt     5100



cgccttttgt ggttttatga ttttcaaatt gaatttaatg attacaccct ttcccttcat     5160



agatcttttt tctttttttt aagccatgct gtgacctaca agcaaactaa atagccaaca     5220



tttctgaacc cctaagtctc ctgtgccaag ctgctccctg aaatggactt cttcatctgt     5280



acagatttgt taaaccattc tatttgcttc ttaataatag gatttatatt agtactcatt     5340



accattggac acaatgacat aagtactctc cacagtaaag cagacctttc acaacagtca     5400



ctctgtgtcc taaaattttc caacatagat gtgatttata taactttgtt gatacgtaaa     5460



ttgtcttggg gtttacggaa attaactatt atgtttgcac taagatttgc tgggagtggt     5520



aggtggacat atctatatat caataaggac taaccgtctt ttttgtacat aggagattga     5580



taatactgta tttgttttaa gcccacagtg ttttactcca ctttcaaaaa gatcaatttg     5640



gcactttttt tcattttttt taatggaaat aagatttggt ctctcatttt aggttaaatg     5700



ataactagaa agattaaact agacagatag tttaggtgga gtatattttt aaaactcaga     5760



acatgtatat tggtcctgtg ttaccaagtt tatatgtgac agttgaaaaa gaaattccct     5820



tgaaatgatc atgaggttaa aattttcttc attaggggac ttggagaacc agtagtcgta     5880



agattagttg atagtttcac tcccaagcaa tgaattgctt ctgtgtgttt ccctgtagga     5940



ctcaatagta aatgctgtct gtcttacaca tttataagga ccctgcaaga cgacgacaaa     6000



ggcctttggc ctgtgctact aaacaagaag cctatgaaaa atttcttctt taaacttgtt     6060



ttttctcttt ccagtaagtt cacatttgga taattttaaa aagaaaagta attacctttg     6120



tgtttccaga acactataat tggggtgtat cttaattcag ttaaatatta ttagtagacc     6180



tggattttcc cccttgaccc catcagtcta taaaggttaa actgcaactt ttatgaaatg     6240



gtctttaata tttccacaat aatcctgtgc tatatttgtt ttaagaaaca aagtaactct     6300



atacacttca agactttaca ggatttttta aatcctgtat tgttggatca attaataaag     6360



atgcaaaaaa actttataga gatgtaaaaa caaaactata atggatctcc tatttttctt     6420



taaatacaaa aaaaaaaagg taaatgaact attctccttg taaagctaaa ttccccattc     6480



tgtctaataa aggaagactg aaaaaaggtt ttaaagaaca taaatggaaa gatacaaatg     6540



ctttgaagga ataaacgaaa tgttaaaaca gggtcaatcc atttgaagaa aaagttggac     6600



aaaataatca gcattgctcc ctcttttatt taatatttgg gtactgatta tatccacatg     6660



gaagtagaag gtaaggagtt taggaaaata ctagaatcta ctctgcttac attcttgttt     6720



aagtgtttac acagtttggt tcaattataa acatttggcc ttttactatg ttatttttat     6780



tttgtatgaa tacattatcc tccttattta tttttgttac atttattact tatgttattt     6840



tgttatgcat ttacaactcc atttttaaat aaagtgtttc tggaacttta aaaaaaaaaa     6900



aaaaaaaaaa                                                            6910





<210>  68

<211>  1486

<212>  PRT

<213>  Homo sapiens



<400>  68



Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His 

1               5                   10                  15      





Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu 

            20                  25                  30          





Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 

        35                  40                  45              





Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn 

    50                  55                  60                  





Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr 

65                  70                  75                  80  





Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Thr Asn Leu Phe 

                85                  90                  95      





Thr Val Val Gln Gly Glu Met Arg Val Pro Glu Glu Ala Leu Lys His 

            100                 105                 110         





Glu Lys Phe Thr Ile Gln Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser 

        115                 120                 125             





Glu Leu Ser Lys Ser Ala Ser Ala Lys Ser Ile Asp Ser Lys Val Ala 

    130                 135                 140                 





Asp Ala Ala Thr Glu Val Gln His Lys Thr Thr Glu Ala Leu Lys Ser 

145                 150                 155                 160 





Glu Glu Lys Ala Met Asp Ile Ser Ala Met Pro Arg Gly Thr Pro Leu 

                165                 170                 175     





Tyr Gly Gln Pro Ser Trp Trp Gly Asp Asp Glu Val Asp Glu Lys Arg 

            180                 185                 190         





Ala Phe Lys Thr Asn Gly Lys Pro Glu Glu Lys Asn His Glu Ala Gly 

        195                 200                 205             





Thr Ser Gly Cys Gly Ile Asp Ala Lys Gln Val Glu Glu Gln Ser Ala 

    210                 215                 220                 





Ala Ala Asn Glu Glu Val Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr 

225                 230                 235                 240 





Phe Glu Ile Pro Thr Lys Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu 

                245                 250                 255     





Ser Thr Ile His Glu Ile Pro Thr Lys Asp Thr Pro Ser Ser His Ile 

            260                 265                 270         





Thr Gly Ala Gly His Ala Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr 

        275                 280                 285             





Pro Gly Lys Val Thr Ile Arg Asp His Val Thr Lys Phe Thr Ser Asp 

    290                 295                 300                 





Gln Arg His Lys Ser Lys Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu 

305                 310                 315                 320 





Gly Ile Gln Thr Gly Met Met Ala Pro Glu Asn Lys Val Ala Asp Trp 

                325                 330                 335     





Leu Ala Gln Asn Asn Pro Pro Gln Met Leu Trp Glu Arg Thr Glu Glu 

            340                 345                 350         





Asp Ser Lys Ser Ile Lys Ser Asp Val Pro Val Tyr Leu Lys Arg Leu 

        355                 360                 365             





Lys Gly Asn Lys His Asp Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala 

    370                 375                 380                 





Gly Ala His Arg Arg Cys Ser Lys Arg Ala Thr Leu Glu Glu His Leu 

385                 390                 395                 400 





Arg Arg His His Ser Glu His Lys Lys Leu Gln Lys Val Gln Ala Thr 

                405                 410                 415     





Glu Lys His Gln Asp Gln Ala Val Val Phe Gly Val Asp Asp Asn Gln 

            420                 425                 430         





Asp Tyr Asn Arg Pro Val Ile Asn Glu Lys His Lys Asp Leu Ile Lys 

        435                 440                 445             





Asp Trp Ala Leu Ser Ser Ala Ala Ala Val Met Glu Glu Arg Lys Pro 

    450                 455                 460                 





Leu Thr Thr Ser Gly Phe His His Ser Glu Glu Gly Thr Ser Ser Ser 

465                 470                 475                 480 





Gly Ser Lys Arg Trp Val Ser Gln Trp Ala Ser Leu Ala Ala Asn His 

                485                 490                 495     





Thr Arg His Asp Gln Glu Glu Arg Ile Met Glu Phe Ser Ala Pro Leu 

            500                 505                 510         





Pro Leu Glu Asn Glu Thr Glu Ile Ser Glu Ser Gly Met Thr Val Arg 

        515                 520                 525             





Ser Thr Gly Ser Ala Thr Ser Leu Ala Ser Gln Gly Glu Arg Arg Arg 

    530                 535                 540                 





Arg Thr Leu Pro Gln Leu Pro Asn Glu Glu Lys Ser Leu Glu Ser His 

545                 550                 555                 560 





Arg Ala Lys Val Val Thr Gln Arg Ser Glu Ile Gly Glu Lys Gln Asp 

                565                 570                 575     





Thr Glu Leu Gln Glu Lys Glu Thr Pro Thr Gln Val Tyr Gln Lys Asp 

            580                 585                 590         





Lys Gln Asp Ala Asp Arg Pro Leu Ser Lys Met Asn Arg Ala Val Asn 

        595                 600                 605             





Gly Glu Thr Leu Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu His Leu 

    610                 615                 620                 





Gly Ser Ser Ala Pro Gly Lys Glu Lys Ser Glu Thr Asp Lys Glu Thr 

625                 630                 635                 640 





Ser Leu Val Lys Gln Thr Leu Ala Lys Leu Gln Gln Gln Glu Gln Arg 

                645                 650                 655     





Glu Glu Ala Gln Trp Thr Pro Thr Lys Leu Ser Ser Lys Asn Val Ser 

            660                 665                 670         





Gly Gln Thr Asp Lys Cys Arg Glu Glu Thr Phe Lys Gln Glu Ser Gln 

        675                 680                 685             





Pro Pro Glu Lys Asn Ser Gly His Ser Thr Ser Lys Gly Asp Arg Val 

    690                 695                 700                 





Ala Gln Ser Glu Ser Lys Arg Arg Lys Ala Glu Glu Ile Leu Lys Ser 

705                 710                 715                 720 





Gln Thr Pro Lys Gly Gly Asp Lys Lys Glu Ser Ser Lys Ser Leu Val 

                725                 730                 735     





Arg Gln Gly Ser Phe Thr Ile Glu Lys Pro Ser Pro Asn Ile Pro Ile 

            740                 745                 750         





Glu Leu Ile Pro His Ile Asn Lys Gln Thr Ser Ser Thr Pro Ser Ser 

        755                 760                 765             





Leu Ala Leu Thr Ser Ala Ser Arg Ile Arg Glu Arg Ser Glu Ser Leu 

    770                 775                 780                 





Asp Pro Asp Ser Ser Met Asp Thr Thr Leu Ile Leu Lys Asp Thr Glu 

785                 790                 795                 800 





Ala Val Met Ala Phe Leu Glu Ala Lys Leu Arg Glu Asp Asn Lys Thr 

                805                 810                 815     





Asp Glu Gly Pro Asp Thr Pro Ser Tyr Asn Arg Asp Asn Ser Ile Ser 

            820                 825                 830         





Pro Glu Ser Asp Val Asp Thr Ala Ser Thr Ile Ser Leu Val Thr Gly 

        835                 840                 845             





Glu Thr Glu Arg Lys Ser Thr Gln Lys Arg Lys Ser Phe Thr Ser Leu 

    850                 855                 860                 





Tyr Lys Asp Arg Cys Ser Thr Gly Ser Pro Ser Lys Asp Val Thr Lys 

865                 870                 875                 880 





Ser Ser Ser Ser Gly Ala Arg Glu Lys Met Glu Lys Lys Thr Lys Ser 

                885                 890                 895     





Arg Ser Thr Asp Val Gly Ser Arg Ala Asp Gly Arg Lys Phe Val Gln 

            900                 905                 910         





Ser Ser Gly Arg Ile Arg Gln Pro Ser Val Asp Leu Thr Asp Asp Asp 

        915                 920                 925             





Gln Thr Ser Ser Val Pro His Ser Ala Ile Ser Asp Ile Met Ser Ser 

    930                 935                 940                 





Asp Gln Glu Thr Tyr Ser Cys Lys Pro His Gly Arg Thr Pro Leu Thr 

945                 950                 955                 960 





Ser Ala Asp Glu His Val His Ser Lys Leu Glu Gly Ser Lys Val Thr 

                965                 970                 975     





Lys Ser Lys Thr Ser Pro Val Val Ser Gly Ser Ser Ser Lys Ser Thr 

            980                 985                 990         





Thr Leu Pro Arg Pro Arg Pro Thr  Arg Thr Ser Leu Leu  Arg Arg Ala 

        995                 1000                 1005             





Arg Leu  Gly Glu Ala Ser Asp  Ser Glu Leu Ala Asp  Ala Asp Lys 

    1010                 1015                 1020             





Ala Ser  Val Ala Ser Glu Val  Ser Thr Thr Ser Ser  Thr Ser Lys 

    1025                 1030                 1035             





Pro Pro  Thr Gly Arg Arg Asn  Ile Ser Arg Ile Asp  Leu Leu Ala 

    1040                 1045                 1050             





Gln Pro  Arg Arg Thr Arg Leu  Gly Ser Leu Ser Ala  Arg Ser Asp 

    1055                 1060                 1065             





Ser Glu  Ala Thr Ile Ser Arg  Ser Ser Ala Ser Ser  Arg Thr Ala 

    1070                 1075                 1080             





Glu Ala  Ile Ile Arg Ser Gly  Ala Arg Leu Val Pro  Ser Asp Lys 

    1085                 1090                 1095             





Phe Ser  Pro Arg Ile Arg Ala  Asn Ser Ile Ser Arg  Leu Ser Asp 

    1100                 1105                 1110             





Ser Lys  Val Lys Ser Met Thr  Ser Ala His Gly Ser  Ala Ser Val 

    1115                 1120                 1125             





Asn Ser  Arg Trp Arg Arg Phe  Pro Thr Asp Tyr Ala  Ser Thr Ser 

    1130                 1135                 1140             





Glu Asp  Glu Phe Gly Ser Asn  Arg Asn Ser Pro Lys  His Thr Arg 

    1145                 1150                 1155             





Leu Arg  Thr Ser Pro Ala Leu  Lys Thr Thr Arg Leu  Gln Ser Ala 

    1160                 1165                 1170             





Gly Ser  Ala Met Pro Thr Ser  Ser Ser Phe Lys His  Arg Ile Lys 

    1175                 1180                 1185             





Glu Gln  Glu Asp Tyr Ile Arg  Asp Trp Thr Ala His  Arg Glu Glu 

    1190                 1195                 1200             





Ile Ala  Arg Ile Ser Gln Asp  Leu Ala Leu Ile Ala  Arg Glu Ile 

    1205                 1210                 1215             





Asn Asp  Val Ala Gly Glu Ile  Asp Ser Val Thr Ser  Ser Gly Thr 

    1220                 1225                 1230             





Ala Pro  Ser Thr Thr Val Ser  Thr Ala Ala Thr Thr  Pro Gly Ser 

    1235                 1240                 1245             





Ala Ile  Asp Thr Arg Glu Glu  Leu Val Asp Arg Val  Phe Asp Glu 

    1250                 1255                 1260             





Ser Leu  Asn Phe Arg Lys Ile  Pro Pro Leu Val His  Ser Lys Thr 

    1265                 1270                 1275             





Pro Glu  Gly Asn Asn Gly Arg  Ser Gly Asp Pro Arg  Pro Gln Ala 

    1280                 1285                 1290             





Ala Glu  Pro Pro Asp His Leu  Thr Ile Thr Arg Arg  Arg Thr Trp 

    1295                 1300                 1305             





Ser Arg  Asp Glu Val Met Gly  Asp Asn Leu Leu Leu  Ser Ser Val 

    1310                 1315                 1320             





Phe Gln  Phe Ser Lys Lys Ile  Arg Gln Ser Ile Asp  Lys Thr Ala 

    1325                 1330                 1335             





Gly Lys  Ile Arg Ile Leu Phe  Lys Asp Lys Asp Arg  Asn Trp Asp 

    1340                 1345                 1350             





Asp Ile  Glu Ser Lys Leu Arg  Ala Glu Ser Glu Val  Pro Ile Val 

    1355                 1360                 1365             





Lys Thr  Ser Ser Met Glu Ile  Ser Ser Ile Leu Gln  Glu Leu Lys 

    1370                 1375                 1380             





Arg Val  Glu Lys Gln Leu Gln  Ala Ile Asn Ala Met  Ile Asp Pro 

    1385                 1390                 1395             





Asp Gly  Thr Leu Glu Ala Leu  Asn Asn Met Gly Phe  Pro Ser Ala 

    1400                 1405                 1410             





Met Leu  Pro Ser Pro Pro Lys  Gln Lys Ser Ser Pro  Val Asn Asn 

    1415                 1420                 1425             





His His  Ser Pro Gly Gln Thr  Pro Thr Leu Gly Gln  Pro Glu Ala 

    1430                 1435                 1440             





Arg Ala  Leu His Pro Ala Ala  Val Ser Ala Ala Ala  Glu Phe Glu 

    1445                 1450                 1455             





Asn Ala  Glu Ser Glu Ala Asp  Phe Ser Ile His Phe  Asn Arg Phe 

    1460                 1465                 1470             





Asn Pro  Asp Gly Glu Glu Glu  Asp Val Thr Val Gln  Glu 

    1475                 1480                 1485     





<210>  69

<211>  6832

<212>  DNA

<213>  Homo sapiens



<400>  69

gggcaagctg gaaaagcgtg tgggtgagac cctcgcacaa ccccttttca ttgtctgtgt       60



gtggcgcctg cgcagtaagg gatcgttgga actgggcagg aggggatagg gtccggctcc      120



tcgccctttc ccgaggcgcc tgcgcactag gcagtcggtc tttgccgtta ccgctatgtg      180



tggggcgtgt gtggaataac gttattgccc agcggagctg agggccccgg agctcgaccg      240



cagcggcagc gacgacaaca gcggcgacga cgacgacgac gaggtggggg gaggacggcg      300



tgcgagagac tcacgggacg cgacgcgccc cgcctccccc gtccggtccc tctctccacg      360



gtaaggggat gacgtagctt tgccaaagac ttagaagcta agcagaaaat gagcttaaca      420



tcctggtttt tggtgagcag tggaggcact cgccacaggc tgccacgaga aatgattttt      480



gttggaagag atgactgtga gctcatgttg cagtctcgta gtgtggataa gcaacacgct      540



gtcatcaact atgatgcgtc tacggatgag catttagtga aggatttggg cagcctcaat      600



gggacttttg tgaatgatgt aaggattccg gaacagactt atatcacctt gaaacttgaa      660



gataagctga gatttggata tgatacaaat cttttcactg tagtacaagg agaaatgagg      720



gtccctgaag aagctcttaa gcatgagaag tttaccattc agcttcagtt gtcccaaaaa      780



tcttcagaat cagaattatc caaatctgca agtgccaaaa gcatagattc aaaggtagca      840



gacgctgcta ctgaagtgca gcacaaaact actgaagcac tgaaatccga ggaaaaagcc      900



atggatattt ctgctatgcc ccgtggtact ccattatatg ggcagccgtc atggtggggg      960



gatgatgagg tggatgaaaa aagagctttc aagacaaatg gcaaacctga agaaaaaaac     1020



catgaagctg gaacatcagg gtgcggcata gatgccaagc aagttgagga acaatctgca     1080



gctgcaaatg aagaagtact ttttcctttc tgtagggaac caagttattt tgaaatccct     1140



acaaaagaat tccagcaacc atcacaaata acagaaagca ctattcatga aatcccaaca     1200



aaagacacgc caagttccca tataacaggt gcagggcatg cttcatttac cattgaattt     1260



gatgacagta ccccagggaa ggtaactatt agagaccatg tgacaaagtt tacttctgat     1320



cagcgccaca agtccaagaa gtcttctcct ggaactcaag acttgctggg gattcaaaca     1380



ggaatgatgg cacccgaaaa caaagttgct gactggctag cacaaaacaa ccctcctcaa     1440



atgctatggg aaagaacaga agaggattct aaaagcatta aaagtgatgt tccagtgtac     1500



ttgaaaaggt tgaaaggaaa taaacatgat gatggtacgc aaagtgattc agagaacgct     1560



ggggctcaca ggcgctgtag caaacgtgca actcttgagg aacacttaag acgccaccat     1620



tcagaacaca aaaagctaca gaaggtccag gctactgaaa agcatcaaga ccaagctgtt     1680



gtgtttggag tagatgacaa tcaggattat aataggcctg ttatcaacga aaaacataaa     1740



gatctaataa aagattgggc tctcagttct gctgcagcag taatggaaga aagaaaacca     1800



ctgactacat ctggatttca ccactcagag gaaggcacat cttcatctgg aagcaaacgt     1860



tgggtttcac agtgggctag tttggctgcc aatcatacaa ggcatgatca agaagaaagg     1920



ataatggaat tttctgcacc tcttccttta gagaatgaga cagagatcag tgagtctggc     1980



atgacagtga gaagtactgg ctctgcaact tccttggcta gccagggaga gagaaggaga     2040



cgaactcttc cccagcttcc aaatgaagaa aagtctcttg agagccacag agcaaaggtt     2100



gtaacacaga ggtcagagat aggagaaaaa caagacacag aacttcagga gaaagaaaca     2160



cctacacagg tataccagaa agataaacaa gatgctgaca gacccttgag taaaatgaac     2220



agggcagtaa atggagagac tctcaaaact ggtggagata ataaaaccct acttcactta     2280



ggcagctctg ctcctggaaa agagaaaagt gaaactgata aggaaacttc tttggtaaag     2340



caaacattag caaaacttca acaacaagaa caaagggagg aggctcagtg gacacctact     2400



aaattgtctt ccaaaaatgt ttcaggtcag acagataaat gtagggagga aacttttaaa     2460



caagaatcac aacctccaga aaaaaattca ggacattcta caagcaaagg agacagagtg     2520



gcacaaagtg agagcaagag aagaaaagct gaggaaattc tgaaaagtca gactccaaag     2580



ggaggagaca agaaggaatc ctccaagtca ttagtgcgac aagggagctt cactatagaa     2640



aaacccagcc caaacatacc catagaactt attccccata taaataaaca gacttcctct     2700



actccttctt ctttagcatt aacatctgca agtagaatac gagaaagaag tgagtctttg     2760



gatcctgatt ctagtatgga cacaaccctt attctaaaag acacagaagc agtaatggct     2820



tttctagaag ctaaactacg tgaagataat aaaactgatg aaggaccaga tactcccagt     2880



tataatagag acaattctat ttcaccagaa tctgatgtag atacagctag tacaatcagt     2940



ctggttactg gagaaactga aagaaagtca acccaaaagc gaaagagttt cactagcctc     3000



tataaagata ggtgttccac aggttctcct tccaaagatg ttacaaaatc atcatcttca     3060



ggtgctaggg aaaaaatgga aaagaaaaca aaaagtcgtt ccacagatgt gggttcaaga     3120



gcagatggtc gtaaatttgt tcagtccagt gggagaataa gacagccctc agtagactta     3180



acagatgatg accaaacctc tagtgtacct cattctgcca tctctgatat tatgtcatct     3240



gatcaagaaa cttactcttg taaacctcat ggacggactc cacttacctc agctgatgag     3300



catgtacatt ccaaactgga aggaagtaaa gtaacgaaat ctaagacttc tccggtggta     3360



tctggttcat ctagtaaatc aaccaccctt ccaaggccac gacctaccag gacttccctc     3420



ttgcgcagag cacgacttgg tgaagcttca gacagtgaac ttgctgatgc tgacaaagca     3480



tctgttgctt ctgaagtatc cacaacaagt tctacatcaa aacctcccac aggaaggcgt     3540



aacatctctc ggattgattt attggctcag cctcgtagaa cacgacttgg ctcactgtca     3600



gctcgtagtg actctgaagc aacaatttct agaagtagtg cctcttcgag gaccgcagaa     3660



gccatcatta gaagtggagc cagactagta ccatcagata aattttctcc tagaattaga     3720



gctaacagta tctctcgact ctcagactcc aaggtcaaaa gtatgacctc agctcatggc     3780



tctgcttcag ccctgaaaac cactcgcttg cagagcgctg gatcagcaat gcctactagt     3840



tcttcattca aacaccggat taaagagcag gaagactaca tccgagattg gactgctcat     3900



cgagaagaga tagccaggat cagccaagat cttgctctca ttgctcggga gatcaacgat     3960



gtagcaggag agatagattc agtgacttca tcaggcactg cccctagtac cacagtaagc     4020



actgctgcca ccacccctgg ctctgccata gacactagag aagaggtagg agatcttcat     4080



ggagaaatgc ataagttggt tgatcgtgtt tttgatgaaa gcctcaactt ccgaaagatt     4140



cctccattag ttcattccaa aacaccagaa ggaaacaacg gtcgatctgg tgatccaaga     4200



cctcaagcag cagagcctcc cgatcactta acaattacaa ggcggagaac ctggagcagg     4260



gatgaagtca tgggagataa tctgctgctg tcatccgtct ttcagttctc taagaagata     4320



agacaatcta tagataagac agctggaaag atcagaatat tatttaaaga caaagatcgg     4380



aattgggatg acatagaaag caaattaaga gccgaaagtg aagtccctat tgtgaaaacc     4440



tcaagcatgg agatttcttc tatcttacag gaactgaaaa gagtagaaaa gcagctgcaa     4500



gcaatcaatg ctatgattga tcctgatgga actttggagg ctctgaacaa catgggattt     4560



cccagtgcta tgttgccatc tccaccgaaa cagaagtcca gccctgtgaa taaccaccac     4620



agcccgggtc agacaccaac acttggccaa ccagaagcta gggctcttca tcctgctgct     4680



gtttcagccg cagctgaatt tgagaatgct gaatctgagg ctgatttcag tatacatttc     4740



aatagattca accccgatgg ggaagaggaa gatgttacag tacaagaatg actttctctt     4800



gattgttgaa aaatcattac ctgtggaatg gctaggaata ttggaagcag catagtgttg     4860



atgtacgcaa aacaagacag cttggtcagc tacaatcttg gaatccctgt cttcttaatt     4920



ttatttattt atttttgacg tataatgtag tatatcaatc ctttcaaact atttagataa     4980



ccacttgatg cacaaatagg aaaaagcaga ttgtggcagt gtcgcctttt gtggttttat     5040



gattttcaaa ttgaatttaa tgattacacc ctttcccttc atagatcttt tttctttttt     5100



ttaagccatg ctgtgaccta caagcaaact aaatagccaa catttctgaa cccctaagtc     5160



tcctgtgcca agctgctccc tgaaatggac ttcttcatct gtacagattt gttaaaccat     5220



tctatttgct tcttaataat aggatttata ttagtactca ttaccattgg acacaatgac     5280



ataagtactc tccacagtaa agcagacctt tcacaacagt cactctgtgt cctaaaattt     5340



tccaacatag atgtgattta tataactttg ttgatacgta aattgtcttg gggtttacgg     5400



aaattaacta ttatgtttgc actaagattt gctgggagtg gtaggtggac atatctatat     5460



atcaataagg actaaccgtc ttttttgtac ataggagatt gataatactg tatttgtttt     5520



aagcccacag tgttttactc cactttcaaa aagatcaatt tggcactttt tttcattttt     5580



tttaatggaa ataagatttg gtctctcatt ttaggttaaa tgataactag aaagattaaa     5640



ctagacagat agtttaggtg gagtatattt ttaaaactca gaacatgtat attggtcctg     5700



tgttaccaag tttatatgtg acagttgaaa aagaaattcc cttgaaatga tcatgaggtt     5760



aaaattttct tcattagggg acttggagaa ccagtagtcg taagattagt tgatagtttc     5820



actcccaagc aatgaattgc ttctgtgtgt ttccctgtag gactcaatag taaatgctgt     5880



ctgtcttaca catttataag gaccctgcaa gacgacgaca aaggcctttg gcctgtgcta     5940



ctaaacaaga agcctatgaa aaatttcttc tttaaacttg ttttttctct ttccagtaag     6000



ttcacatttg gataatttta aaaagaaaag taattacctt tgtgtttcca gaacactata     6060



attggggtgt atcttaattc agttaaatat tattagtaga cctggatttt cccccttgac     6120



cccatcagtc tataaaggtt aaactgcaac ttttatgaaa tggtctttaa tatttccaca     6180



ataatcctgt gctatatttg ttttaagaaa caaagtaact ctatacactt caagacttta     6240



caggattttt taaatcctgt attgttggat caattaataa agatgcaaaa aaactttata     6300



gagatgtaaa aacaaaacta taatggatct cctatttttc tttaaataca aaaaaaaaaa     6360



ggtaaatgaa ctattctcct tgtaaagcta aattccccat tctgtctaat aaaggaagac     6420



tgaaaaaagg ttttaaagaa cataaatgga aagatacaaa tgctttgaag gaataaacga     6480



aatgttaaaa cagggtcaat ccatttgaag aaaaagttgg acaaaataat cagcattgct     6540



ccctctttta tttaatattt gggtactgat tatatccaca tggaagtaga aggtaaggag     6600



tttaggaaaa tactagaatc tactctgctt acattcttgt ttaagtgttt acacagtttg     6660



gttcaattat aaacatttgg ccttttacta tgttattttt attttgtatg aatacattat     6720



cctccttatt tatttttgtt acatttatta cttatgttat tttgttatgc atttacaact     6780



ccatttttaa ataaagtgtt tctggaactt taaaaaaaaa aaaaaaaaaa aa             6832





<210>  70

<211>  1460

<212>  PRT

<213>  Homo sapiens



<400>  70



Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His 

1               5                   10                  15      





Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu 

            20                  25                  30          





Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 

        35                  40                  45              





Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn 

    50                  55                  60                  





Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr 

65                  70                  75                  80  





Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Thr Asn Leu Phe 

                85                  90                  95      





Thr Val Val Gln Gly Glu Met Arg Val Pro Glu Glu Ala Leu Lys His 

            100                 105                 110         





Glu Lys Phe Thr Ile Gln Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser 

        115                 120                 125             





Glu Leu Ser Lys Ser Ala Ser Ala Lys Ser Ile Asp Ser Lys Val Ala 

    130                 135                 140                 





Asp Ala Ala Thr Glu Val Gln His Lys Thr Thr Glu Ala Leu Lys Ser 

145                 150                 155                 160 





Glu Glu Lys Ala Met Asp Ile Ser Ala Met Pro Arg Gly Thr Pro Leu 

                165                 170                 175     





Tyr Gly Gln Pro Ser Trp Trp Gly Asp Asp Glu Val Asp Glu Lys Arg 

            180                 185                 190         





Ala Phe Lys Thr Asn Gly Lys Pro Glu Glu Lys Asn His Glu Ala Gly 

        195                 200                 205             





Thr Ser Gly Cys Gly Ile Asp Ala Lys Gln Val Glu Glu Gln Ser Ala 

    210                 215                 220                 





Ala Ala Asn Glu Glu Val Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr 

225                 230                 235                 240 





Phe Glu Ile Pro Thr Lys Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu 

                245                 250                 255     





Ser Thr Ile His Glu Ile Pro Thr Lys Asp Thr Pro Ser Ser His Ile 

            260                 265                 270         





Thr Gly Ala Gly His Ala Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr 

        275                 280                 285             





Pro Gly Lys Val Thr Ile Arg Asp His Val Thr Lys Phe Thr Ser Asp 

    290                 295                 300                 





Gln Arg His Lys Ser Lys Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu 

305                 310                 315                 320 





Gly Ile Gln Thr Gly Met Met Ala Pro Glu Asn Lys Val Ala Asp Trp 

                325                 330                 335     





Leu Ala Gln Asn Asn Pro Pro Gln Met Leu Trp Glu Arg Thr Glu Glu 

            340                 345                 350         





Asp Ser Lys Ser Ile Lys Ser Asp Val Pro Val Tyr Leu Lys Arg Leu 

        355                 360                 365             





Lys Gly Asn Lys His Asp Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala 

    370                 375                 380                 





Gly Ala His Arg Arg Cys Ser Lys Arg Ala Thr Leu Glu Glu His Leu 

385                 390                 395                 400 





Arg Arg His His Ser Glu His Lys Lys Leu Gln Lys Val Gln Ala Thr 

                405                 410                 415     





Glu Lys His Gln Asp Gln Ala Val Val Phe Gly Val Asp Asp Asn Gln 

            420                 425                 430         





Asp Tyr Asn Arg Pro Val Ile Asn Glu Lys His Lys Asp Leu Ile Lys 

        435                 440                 445             





Asp Trp Ala Leu Ser Ser Ala Ala Ala Val Met Glu Glu Arg Lys Pro 

    450                 455                 460                 





Leu Thr Thr Ser Gly Phe His His Ser Glu Glu Gly Thr Ser Ser Ser 

465                 470                 475                 480 





Gly Ser Lys Arg Trp Val Ser Gln Trp Ala Ser Leu Ala Ala Asn His 

                485                 490                 495     





Thr Arg His Asp Gln Glu Glu Arg Ile Met Glu Phe Ser Ala Pro Leu 

            500                 505                 510         





Pro Leu Glu Asn Glu Thr Glu Ile Ser Glu Ser Gly Met Thr Val Arg 

        515                 520                 525             





Ser Thr Gly Ser Ala Thr Ser Leu Ala Ser Gln Gly Glu Arg Arg Arg 

    530                 535                 540                 





Arg Thr Leu Pro Gln Leu Pro Asn Glu Glu Lys Ser Leu Glu Ser His 

545                 550                 555                 560 





Arg Ala Lys Val Val Thr Gln Arg Ser Glu Ile Gly Glu Lys Gln Asp 

                565                 570                 575     





Thr Glu Leu Gln Glu Lys Glu Thr Pro Thr Gln Val Tyr Gln Lys Asp 

            580                 585                 590         





Lys Gln Asp Ala Asp Arg Pro Leu Ser Lys Met Asn Arg Ala Val Asn 

        595                 600                 605             





Gly Glu Thr Leu Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu His Leu 

    610                 615                 620                 





Gly Ser Ser Ala Pro Gly Lys Glu Lys Ser Glu Thr Asp Lys Glu Thr 

625                 630                 635                 640 





Ser Leu Val Lys Gln Thr Leu Ala Lys Leu Gln Gln Gln Glu Gln Arg 

                645                 650                 655     





Glu Glu Ala Gln Trp Thr Pro Thr Lys Leu Ser Ser Lys Asn Val Ser 

            660                 665                 670         





Gly Gln Thr Asp Lys Cys Arg Glu Glu Thr Phe Lys Gln Glu Ser Gln 

        675                 680                 685             





Pro Pro Glu Lys Asn Ser Gly His Ser Thr Ser Lys Gly Asp Arg Val 

    690                 695                 700                 





Ala Gln Ser Glu Ser Lys Arg Arg Lys Ala Glu Glu Ile Leu Lys Ser 

705                 710                 715                 720 





Gln Thr Pro Lys Gly Gly Asp Lys Lys Glu Ser Ser Lys Ser Leu Val 

                725                 730                 735     





Arg Gln Gly Ser Phe Thr Ile Glu Lys Pro Ser Pro Asn Ile Pro Ile 

            740                 745                 750         





Glu Leu Ile Pro His Ile Asn Lys Gln Thr Ser Ser Thr Pro Ser Ser 

        755                 760                 765             





Leu Ala Leu Thr Ser Ala Ser Arg Ile Arg Glu Arg Ser Glu Ser Leu 

    770                 775                 780                 





Asp Pro Asp Ser Ser Met Asp Thr Thr Leu Ile Leu Lys Asp Thr Glu 

785                 790                 795                 800 





Ala Val Met Ala Phe Leu Glu Ala Lys Leu Arg Glu Asp Asn Lys Thr 

                805                 810                 815     





Asp Glu Gly Pro Asp Thr Pro Ser Tyr Asn Arg Asp Asn Ser Ile Ser 

            820                 825                 830         





Pro Glu Ser Asp Val Asp Thr Ala Ser Thr Ile Ser Leu Val Thr Gly 

        835                 840                 845             





Glu Thr Glu Arg Lys Ser Thr Gln Lys Arg Lys Ser Phe Thr Ser Leu 

    850                 855                 860                 





Tyr Lys Asp Arg Cys Ser Thr Gly Ser Pro Ser Lys Asp Val Thr Lys 

865                 870                 875                 880 





Ser Ser Ser Ser Gly Ala Arg Glu Lys Met Glu Lys Lys Thr Lys Ser 

                885                 890                 895     





Arg Ser Thr Asp Val Gly Ser Arg Ala Asp Gly Arg Lys Phe Val Gln 

            900                 905                 910         





Ser Ser Gly Arg Ile Arg Gln Pro Ser Val Asp Leu Thr Asp Asp Asp 

        915                 920                 925             





Gln Thr Ser Ser Val Pro His Ser Ala Ile Ser Asp Ile Met Ser Ser 

    930                 935                 940                 





Asp Gln Glu Thr Tyr Ser Cys Lys Pro His Gly Arg Thr Pro Leu Thr 

945                 950                 955                 960 





Ser Ala Asp Glu His Val His Ser Lys Leu Glu Gly Ser Lys Val Thr 

                965                 970                 975     





Lys Ser Lys Thr Ser Pro Val Val Ser Gly Ser Ser Ser Lys Ser Thr 

            980                 985                 990         





Thr Leu Pro Arg Pro Arg Pro Thr  Arg Thr Ser Leu Leu  Arg Arg Ala 

        995                 1000                 1005             





Arg Leu  Gly Glu Ala Ser Asp  Ser Glu Leu Ala Asp  Ala Asp Lys 

    1010                 1015                 1020             





Ala Ser  Val Ala Ser Glu Val  Ser Thr Thr Ser Ser  Thr Ser Lys 

    1025                 1030                 1035             





Pro Pro  Thr Gly Arg Arg Asn  Ile Ser Arg Ile Asp  Leu Leu Ala 

    1040                 1045                 1050             





Gln Pro  Arg Arg Thr Arg Leu  Gly Ser Leu Ser Ala  Arg Ser Asp 

    1055                 1060                 1065             





Ser Glu  Ala Thr Ile Ser Arg  Ser Ser Ala Ser Ser  Arg Thr Ala 

    1070                 1075                 1080             





Glu Ala  Ile Ile Arg Ser Gly  Ala Arg Leu Val Pro  Ser Asp Lys 

    1085                 1090                 1095             





Phe Ser  Pro Arg Ile Arg Ala  Asn Ser Ile Ser Arg  Leu Ser Asp 

    1100                 1105                 1110             





Ser Lys  Val Lys Ser Met Thr  Ser Ala His Gly Ser  Ala Ser Ala 

    1115                 1120                 1125             





Leu Lys  Thr Thr Arg Leu Gln  Ser Ala Gly Ser Ala  Met Pro Thr 

    1130                 1135                 1140             





Ser Ser  Ser Phe Lys His Arg  Ile Lys Glu Gln Glu  Asp Tyr Ile 

    1145                 1150                 1155             





Arg Asp  Trp Thr Ala His Arg  Glu Glu Ile Ala Arg  Ile Ser Gln 

    1160                 1165                 1170             





Asp Leu  Ala Leu Ile Ala Arg  Glu Ile Asn Asp Val  Ala Gly Glu 

    1175                 1180                 1185             





Ile Asp  Ser Val Thr Ser Ser  Gly Thr Ala Pro Ser  Thr Thr Val 

    1190                 1195                 1200             





Ser Thr  Ala Ala Thr Thr Pro  Gly Ser Ala Ile Asp  Thr Arg Glu 

    1205                 1210                 1215             





Glu Val  Gly Asp Leu His Gly  Glu Met His Lys Leu  Val Asp Arg 

    1220                 1225                 1230             





Val Phe  Asp Glu Ser Leu Asn  Phe Arg Lys Ile Pro  Pro Leu Val 

    1235                 1240                 1245             





His Ser  Lys Thr Pro Glu Gly  Asn Asn Gly Arg Ser  Gly Asp Pro 

    1250                 1255                 1260             





Arg Pro  Gln Ala Ala Glu Pro  Pro Asp His Leu Thr  Ile Thr Arg 

    1265                 1270                 1275             





Arg Arg  Thr Trp Ser Arg Asp  Glu Val Met Gly Asp  Asn Leu Leu 

    1280                 1285                 1290             





Leu Ser  Ser Val Phe Gln Phe  Ser Lys Lys Ile Arg  Gln Ser Ile 

    1295                 1300                 1305             





Asp Lys  Thr Ala Gly Lys Ile  Arg Ile Leu Phe Lys  Asp Lys Asp 

    1310                 1315                 1320             





Arg Asn  Trp Asp Asp Ile Glu  Ser Lys Leu Arg Ala  Glu Ser Glu 

    1325                 1330                 1335             





Val Pro  Ile Val Lys Thr Ser  Ser Met Glu Ile Ser  Ser Ile Leu 

    1340                 1345                 1350             





Gln Glu  Leu Lys Arg Val Glu  Lys Gln Leu Gln Ala  Ile Asn Ala 

    1355                 1360                 1365             





Met Ile  Asp Pro Asp Gly Thr  Leu Glu Ala Leu Asn  Asn Met Gly 

    1370                 1375                 1380             





Phe Pro  Ser Ala Met Leu Pro  Ser Pro Pro Lys Gln  Lys Ser Ser 

    1385                 1390                 1395             





Pro Val  Asn Asn His His Ser  Pro Gly Gln Thr Pro  Thr Leu Gly 

    1400                 1405                 1410             





Gln Pro  Glu Ala Arg Ala Leu  His Pro Ala Ala Val  Ser Ala Ala 

    1415                 1420                 1425             





Ala Glu  Phe Glu Asn Ala Glu  Ser Glu Ala Asp Phe  Ser Ile His 

    1430                 1435                 1440             





Phe Asn  Arg Phe Asn Pro Asp  Gly Glu Glu Glu Asp  Val Thr Val 

    1445                 1450                 1455             





Gln Glu  

    1460 





<210>  71

<211>  7204

<212>  DNA

<213>  Homo sapiens



<400>  71

gggcaagctg gaaaagcgtg tgggtgagac cctcgcacaa ccccttttca ttgtctgtgt       60



gtggcgcctg cgcagtaagg gatcgttgga actgggcagg aggggatagg gtccggctcc      120



tcgccctttc ccgaggcgcc tgcgcactag gcagtcggtc tttgccgtta ccgctatgtg      180



tggggcgtgt gtggaataac gttattgccc agcggagctg agggccccgg agctcgaccg      240



cagcggcagc gacgacaaca gcggcgacga cgacgacgac gaggtggggg gaggacggcg      300



tgcgagagac tcacgggacg cgacgcgccc cgcctccccc gtccggtccc tctctccacg      360



gtaaggggat gacgtagctt tgccaaagac ttagaagcta agcagaaaat gagcttaaca      420



tcctggtttt tggtgagcag tggaggcact cgccacaggc tgccacgaga aatgattttt      480



gttggaagag atgactgtga gctcatgttg cagtctcgta gtgtggataa gcaacacgct      540



gtcatcaact atgatgcgtc tacggatgag catttagtga aggatttggg cagcctcaat      600



gggacttttg tgaatgatgt aaggattccg gaacagactt atatcacctt gaaacttgaa      660



gataagctga gatttggata tgatacaaat cttttcactg tagtacaagg agaaatgagg      720



gtccctgaag aagctcttaa gcatgagaag tttaccattc agcttcagtt gtcccaaaaa      780



tcttcagaat cagaattatc caaatctgca agtgccaaaa gcatagattc aaaggtagca      840



gacgctgcta ctgaagtgca gcacaaaact actgaagcac tgaaatccga ggaaaaagcc      900



atggatattt ctgctatgcc ccgtggtact ccattatatg ggcagccgtc atggtggggg      960



gatgatgagg tggatgaaaa aagagctttc aagacaaatg gcaaacctga agaaaaaaac     1020



catgaagctg gaacatcagg gtgcggcata gatgccaagc aagttgagga acaatctgca     1080



gctgcaaatg aagaagtact ttttcctttc tgtagggaac caagttattt tgaaatccct     1140



acaaaagaat tccagcaacc atcacaaata acagaaagca ctattcatga aatcccaaca     1200



aaagacacgc caagttccca tataacaggt gcagggcatg cttcatttac cattgaattt     1260



gatgacagta ccccagggaa ggtaactatt agagaccatg tgacaaagtt tacttctgat     1320



cagcgccaca agtccaagaa gtcttctcct ggaactcaag acttgctggg gattcaaaca     1380



ggaatgatgg cacccgaaaa caaagttgct gactggctag cacaaaacaa ccctcctcaa     1440



atgctatggg aaagaacaga agaggattct aaaagcatta aaagtgatgt tccagtgtac     1500



ttgaaaaggt tgaaaggaaa taaacatgat gatggtacgc aaagtgattc agagaacgct     1560



ggggctcaca ggcgctgtag caaacgtgca actcttgagg aacacttaag acgccaccat     1620



tcagaacaca aaaagctaca gaaggtccag gctactgaaa agcatcaaga ccaagctgtt     1680



actagctctg cgcatcacag aggggggcat ggtgttccac atgggaaatt gttaaaacag     1740



aaatcagagg agccatcggt gtcaataccc ttcctacaaa ctgcattatt aagaagttca     1800



gggagtcttg ggcacagacc aagccaggag atggataaaa tgttaaaaaa tcaagcaact     1860



tctgctactt ctgaaaagga taatgatgat gaccaaagtg acaagggtac ttataccatt     1920



gagttagaga atcccaacag tgaggaagtg gaagcaagaa aaatgattga caaggtgttt     1980



ggagtagatg acaatcagga ttataatagg cctgttatca acgaaaaaca taaagatcta     2040



ataaaagatt gggctctcag ttctgctgca gcagtaatgg aagaaagaaa accactgact     2100



acatctggat ttcaccactc agaggaaggc acatcttcat ctggaagcaa acgttgggtt     2160



tcacagtggg ctagtttggc tgccaatcat acaaggcatg atcaagaaga aaggataatg     2220



gaattttctg cacctcttcc tttagagaat gagacagaga tcagtgagtc tggcatgaca     2280



gtgagaagta ctggctctgc aacttccttg gctagccagg gagagagaag gagacgaact     2340



cttccccagc ttccaaatga agaaaagtct cttgagagcc acagagcaaa ggttgtaaca     2400



cagaggtcag agataggaga aaaacaagac acagaacttc aggagaaaga aacacctaca     2460



caggtatacc agaaagataa acaagatgct gacagaccct tgagtaaaat gaacagggca     2520



gtaaatggag agactctcaa aactggtgga gataataaaa ccctacttca cttaggcagc     2580



tctgctcctg gaaaagagaa aagtgaaact gataaggaaa cttctttggt aaagcaaaca     2640



ttagcaaaac ttcaacaaca agaacaaagg gaggaggctc agtggacacc tactaaattg     2700



tcttccaaaa atgtttcagg tcagacagat aaatgtaggg aggaaacttt taaacaagaa     2760



tcacaacctc cagaaaaaaa ttcaggacat tctacaagca aaggagacag agtggcacaa     2820



agtgagagca agagaagaaa agctgaggaa attctgaaaa gtcagactcc aaagggagga     2880



gacaagaagg aatcctccaa gtcattagtg cgacaaggga gcttcactat agaaaaaccc     2940



agcccaaaca tacccataga acttattccc catataaata aacagacttc ctctactcct     3000



tcttctttag cattaacatc tgcaagtaga atacgagaaa gaagtgagtc tttggatcct     3060



gattctagta tggacacaac ccttattcta aaagacacag aagcagtaat ggcttttcta     3120



gaagctaaac tacgtgaaga taataaaact gatgaaggac cagatactcc cagttataat     3180



agagacaatt ctatttcacc agaatctgat gtagatacag ctagtacaat cagtctggtt     3240



actggagaaa ctgaaagaaa gtcaacccaa aagcgaaaga gtttcactag cctctataaa     3300



gataggtgtt ccacaggttc tccttccaaa gatgttacaa aatcatcatc ttcaggtgct     3360



agggaaaaaa tggaaaagaa aacaaaaagt cgttccacag atgtgggttc aagagcagat     3420



ggtcgtaaat ttgttcagtc cagtgggaga ataagacagc cctcagtaga cttaacagat     3480



gatgaccaaa cctctagtgt acctcattct gccatctctg atattatgtc atctgatcaa     3540



gaaacttact cttgtaaacc tcatggacgg actccactta cctcagctga tgagcatgta     3600



cattccaaac tggaaggaag taaagtaacg aaatctaaga cttctccggt ggtatctggt     3660



tcatctagta aatcaaccac ccttccaagg ccacgaccta ccaggacttc cctcttgcgc     3720



agagcacgac ttggtgaagc ttcagacagt gaacttgctg atgctgacaa agcatctgtt     3780



gcttctgaag tatccacaac aagttctaca tcaaaacctc ccacaggaag gcgtaacatc     3840



tctcggattg atttattggc tcagcctcgt agaacacgac ttggctcact gtcagctcgt     3900



agtgactctg aagcaacaat ttctagaagt agtgcctctt cgaggaccgc agaagccatc     3960



attagaagtg gagccagact agtaccatca gataaatttt ctcctagaat tagagctaac     4020



agtatctctc gactctcaga ctccaaggtc aaaagtatga cctcagctca tggctctgct     4080



tcagtaaatt caagatggag gcgctttcct actgattatg cttccacctc agaagatgaa     4140



tttggatcaa accgtaattc ccctaaacat acccgtctac gtacttctcc agccctgaaa     4200



accactcgct tgcagagcgc tggatcagca atgcctacta gttcttcatt caaacaccgg     4260



attaaagagc aggaagacta catccgagat tggactgctc atcgagaaga gatagccagg     4320



atcagccaag atcttgctct cattgctcgg gagatcaacg atgtagcagg agagatagat     4380



tcagtgactt catcaggcac tgcccctagt accacagtaa gcactgctgc caccacccct     4440



ggctctgcca tagacactag agaagagttg gttgatcgtg tttttgatga aagcctcaac     4500



ttccgaaaga ttcctccatt agttcattcc aaaacaccag aaggaaacaa cggtcgatct     4560



ggtgatccaa gacctcaagc agcagagcct cccgatcact taacaattac aaggcggaga     4620



acctggagca gggatgaagt catgggagat aatctgctgc tgtcatccgt ctttcagttc     4680



tctaagaaga taagacaatc tatagataag acagctggaa agatcagaat attatttaaa     4740



gacaaagatc ggaattggga tgacatagaa agcaaattaa gagccgaaag tgaagtccct     4800



attgtgaaaa cctcaagcat ggagatttct tctatcttac aggaactgaa aagagtagaa     4860



aagcagctgc aagcaatcaa tgctatgatt gatcctgatg gaactttgga ggctctgaac     4920



aacatgggat ttcccagtgc tatgttgcca tctccaccga aacagaagtc cagccctgtg     4980



aataaccacc acagcccggg tcagacacca acacttggcc aaccagaagc tagggctctt     5040



catcctgctg ctgtttcagc cgcagctgaa tttgagaatg ctgaatctga ggctgatttc     5100



agtatacatt tcaatagatt caaccccgat ggggaagagg aagatgttac agtacaagaa     5160



tgactttctc ttgattgttg aaaaatcatt acctgtggaa tggctaggaa tattggaagc     5220



agcatagtgt tgatgtacgc aaaacaagac agcttggtca gctacaatct tggaatccct     5280



gtcttcttaa ttttatttat ttatttttga cgtataatgt agtatatcaa tcctttcaaa     5340



ctatttagat aaccacttga tgcacaaata ggaaaaagca gattgtggca gtgtcgcctt     5400



ttgtggtttt atgattttca aattgaattt aatgattaca ccctttccct tcatagatct     5460



tttttctttt ttttaagcca tgctgtgacc tacaagcaaa ctaaatagcc aacatttctg     5520



aacccctaag tctcctgtgc caagctgctc cctgaaatgg acttcttcat ctgtacagat     5580



ttgttaaacc attctatttg cttcttaata ataggattta tattagtact cattaccatt     5640



ggacacaatg acataagtac tctccacagt aaagcagacc tttcacaaca gtcactctgt     5700



gtcctaaaat tttccaacat agatgtgatt tatataactt tgttgatacg taaattgtct     5760



tggggtttac ggaaattaac tattatgttt gcactaagat ttgctgggag tggtaggtgg     5820



acatatctat atatcaataa ggactaaccg tcttttttgt acataggaga ttgataatac     5880



tgtatttgtt ttaagcccac agtgttttac tccactttca aaaagatcaa tttggcactt     5940



tttttcattt tttttaatgg aaataagatt tggtctctca ttttaggtta aatgataact     6000



agaaagatta aactagacag atagtttagg tggagtatat ttttaaaact cagaacatgt     6060



atattggtcc tgtgttacca agtttatatg tgacagttga aaaagaaatt cccttgaaat     6120



gatcatgagg ttaaaatttt cttcattagg ggacttggag aaccagtagt cgtaagatta     6180



gttgatagtt tcactcccaa gcaatgaatt gcttctgtgt gtttccctgt aggactcaat     6240



agtaaatgct gtctgtctta cacatttata aggaccctgc aagacgacga caaaggcctt     6300



tggcctgtgc tactaaacaa gaagcctatg aaaaatttct tctttaaact tgttttttct     6360



ctttccagta agttcacatt tggataattt taaaaagaaa agtaattacc tttgtgtttc     6420



cagaacacta taattggggt gtatcttaat tcagttaaat attattagta gacctggatt     6480



ttcccccttg accccatcag tctataaagg ttaaactgca acttttatga aatggtcttt     6540



aatatttcca caataatcct gtgctatatt tgttttaaga aacaaagtaa ctctatacac     6600



ttcaagactt tacaggattt tttaaatcct gtattgttgg atcaattaat aaagatgcaa     6660



aaaaacttta tagagatgta aaaacaaaac tataatggat ctcctatttt tctttaaata     6720



caaaaaaaaa aaggtaaatg aactattctc cttgtaaagc taaattcccc attctgtcta     6780



ataaaggaag actgaaaaaa ggttttaaag aacataaatg gaaagataca aatgctttga     6840



aggaataaac gaaatgttaa aacagggtca atccatttga agaaaaagtt ggacaaaata     6900



atcagcattg ctccctcttt tatttaatat ttgggtactg attatatcca catggaagta     6960



gaaggtaagg agtttaggaa aatactagaa tctactctgc ttacattctt gtttaagtgt     7020



ttacacagtt tggttcaatt ataaacattt ggccttttac tatgttattt ttattttgta     7080



tgaatacatt atcctcctta tttatttttg ttacatttat tacttatgtt attttgttat     7140



gcatttacaa ctccattttt aaataaagtg tttctggaac tttaaaaaaa aaaaaaaaaa     7200



aaaa                                                                  7204





<210>  72

<211>  1584

<212>  PRT

<213>  Homo sapiens



<400>  72



Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His 

1               5                   10                  15      





Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu 

            20                  25                  30          





Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 

        35                  40                  45              





Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn 

    50                  55                  60                  





Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr 

65                  70                  75                  80  





Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Thr Asn Leu Phe 

                85                  90                  95      





Thr Val Val Gln Gly Glu Met Arg Val Pro Glu Glu Ala Leu Lys His 

            100                 105                 110         





Glu Lys Phe Thr Ile Gln Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser 

        115                 120                 125             





Glu Leu Ser Lys Ser Ala Ser Ala Lys Ser Ile Asp Ser Lys Val Ala 

    130                 135                 140                 





Asp Ala Ala Thr Glu Val Gln His Lys Thr Thr Glu Ala Leu Lys Ser 

145                 150                 155                 160 





Glu Glu Lys Ala Met Asp Ile Ser Ala Met Pro Arg Gly Thr Pro Leu 

                165                 170                 175     





Tyr Gly Gln Pro Ser Trp Trp Gly Asp Asp Glu Val Asp Glu Lys Arg 

            180                 185                 190         





Ala Phe Lys Thr Asn Gly Lys Pro Glu Glu Lys Asn His Glu Ala Gly 

        195                 200                 205             





Thr Ser Gly Cys Gly Ile Asp Ala Lys Gln Val Glu Glu Gln Ser Ala 

    210                 215                 220                 





Ala Ala Asn Glu Glu Val Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr 

225                 230                 235                 240 





Phe Glu Ile Pro Thr Lys Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu 

                245                 250                 255     





Ser Thr Ile His Glu Ile Pro Thr Lys Asp Thr Pro Ser Ser His Ile 

            260                 265                 270         





Thr Gly Ala Gly His Ala Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr 

        275                 280                 285             





Pro Gly Lys Val Thr Ile Arg Asp His Val Thr Lys Phe Thr Ser Asp 

    290                 295                 300                 





Gln Arg His Lys Ser Lys Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu 

305                 310                 315                 320 





Gly Ile Gln Thr Gly Met Met Ala Pro Glu Asn Lys Val Ala Asp Trp 

                325                 330                 335     





Leu Ala Gln Asn Asn Pro Pro Gln Met Leu Trp Glu Arg Thr Glu Glu 

            340                 345                 350         





Asp Ser Lys Ser Ile Lys Ser Asp Val Pro Val Tyr Leu Lys Arg Leu 

        355                 360                 365             





Lys Gly Asn Lys His Asp Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala 

    370                 375                 380                 





Gly Ala His Arg Arg Cys Ser Lys Arg Ala Thr Leu Glu Glu His Leu 

385                 390                 395                 400 





Arg Arg His His Ser Glu His Lys Lys Leu Gln Lys Val Gln Ala Thr 

                405                 410                 415     





Glu Lys His Gln Asp Gln Ala Val Thr Ser Ser Ala His His Arg Gly 

            420                 425                 430         





Gly His Gly Val Pro His Gly Lys Leu Leu Lys Gln Lys Ser Glu Glu 

        435                 440                 445             





Pro Ser Val Ser Ile Pro Phe Leu Gln Thr Ala Leu Leu Arg Ser Ser 

    450                 455                 460                 





Gly Ser Leu Gly His Arg Pro Ser Gln Glu Met Asp Lys Met Leu Lys 

465                 470                 475                 480 





Asn Gln Ala Thr Ser Ala Thr Ser Glu Lys Asp Asn Asp Asp Asp Gln 

                485                 490                 495     





Ser Asp Lys Gly Thr Tyr Thr Ile Glu Leu Glu Asn Pro Asn Ser Glu 

            500                 505                 510         





Glu Val Glu Ala Arg Lys Met Ile Asp Lys Val Phe Gly Val Asp Asp 

        515                 520                 525             





Asn Gln Asp Tyr Asn Arg Pro Val Ile Asn Glu Lys His Lys Asp Leu 

    530                 535                 540                 





Ile Lys Asp Trp Ala Leu Ser Ser Ala Ala Ala Val Met Glu Glu Arg 

545                 550                 555                 560 





Lys Pro Leu Thr Thr Ser Gly Phe His His Ser Glu Glu Gly Thr Ser 

                565                 570                 575     





Ser Ser Gly Ser Lys Arg Trp Val Ser Gln Trp Ala Ser Leu Ala Ala 

            580                 585                 590         





Asn His Thr Arg His Asp Gln Glu Glu Arg Ile Met Glu Phe Ser Ala 

        595                 600                 605             





Pro Leu Pro Leu Glu Asn Glu Thr Glu Ile Ser Glu Ser Gly Met Thr 

    610                 615                 620                 





Val Arg Ser Thr Gly Ser Ala Thr Ser Leu Ala Ser Gln Gly Glu Arg 

625                 630                 635                 640 





Arg Arg Arg Thr Leu Pro Gln Leu Pro Asn Glu Glu Lys Ser Leu Glu 

                645                 650                 655     





Ser His Arg Ala Lys Val Val Thr Gln Arg Ser Glu Ile Gly Glu Lys 

            660                 665                 670         





Gln Asp Thr Glu Leu Gln Glu Lys Glu Thr Pro Thr Gln Val Tyr Gln 

        675                 680                 685             





Lys Asp Lys Gln Asp Ala Asp Arg Pro Leu Ser Lys Met Asn Arg Ala 

    690                 695                 700                 





Val Asn Gly Glu Thr Leu Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu 

705                 710                 715                 720 





His Leu Gly Ser Ser Ala Pro Gly Lys Glu Lys Ser Glu Thr Asp Lys 

                725                 730                 735     





Glu Thr Ser Leu Val Lys Gln Thr Leu Ala Lys Leu Gln Gln Gln Glu 

            740                 745                 750         





Gln Arg Glu Glu Ala Gln Trp Thr Pro Thr Lys Leu Ser Ser Lys Asn 

        755                 760                 765             





Val Ser Gly Gln Thr Asp Lys Cys Arg Glu Glu Thr Phe Lys Gln Glu 

    770                 775                 780                 





Ser Gln Pro Pro Glu Lys Asn Ser Gly His Ser Thr Ser Lys Gly Asp 

785                 790                 795                 800 





Arg Val Ala Gln Ser Glu Ser Lys Arg Arg Lys Ala Glu Glu Ile Leu 

                805                 810                 815     





Lys Ser Gln Thr Pro Lys Gly Gly Asp Lys Lys Glu Ser Ser Lys Ser 

            820                 825                 830         





Leu Val Arg Gln Gly Ser Phe Thr Ile Glu Lys Pro Ser Pro Asn Ile 

        835                 840                 845             





Pro Ile Glu Leu Ile Pro His Ile Asn Lys Gln Thr Ser Ser Thr Pro 

    850                 855                 860                 





Ser Ser Leu Ala Leu Thr Ser Ala Ser Arg Ile Arg Glu Arg Ser Glu 

865                 870                 875                 880 





Ser Leu Asp Pro Asp Ser Ser Met Asp Thr Thr Leu Ile Leu Lys Asp 

                885                 890                 895     





Thr Glu Ala Val Met Ala Phe Leu Glu Ala Lys Leu Arg Glu Asp Asn 

            900                 905                 910         





Lys Thr Asp Glu Gly Pro Asp Thr Pro Ser Tyr Asn Arg Asp Asn Ser 

        915                 920                 925             





Ile Ser Pro Glu Ser Asp Val Asp Thr Ala Ser Thr Ile Ser Leu Val 

    930                 935                 940                 





Thr Gly Glu Thr Glu Arg Lys Ser Thr Gln Lys Arg Lys Ser Phe Thr 

945                 950                 955                 960 





Ser Leu Tyr Lys Asp Arg Cys Ser Thr Gly Ser Pro Ser Lys Asp Val 

                965                 970                 975     





Thr Lys Ser Ser Ser Ser Gly Ala Arg Glu Lys Met Glu Lys Lys Thr 

            980                 985                 990         





Lys Ser Arg Ser Thr Asp Val Gly  Ser Arg Ala Asp Gly  Arg Lys Phe 

        995                 1000                 1005             





Val Gln  Ser Ser Gly Arg Ile  Arg Gln Pro Ser Val  Asp Leu Thr 

    1010                 1015                 1020             





Asp Asp  Asp Gln Thr Ser Ser  Val Pro His Ser Ala  Ile Ser Asp 

    1025                 1030                 1035             





Ile Met  Ser Ser Asp Gln Glu  Thr Tyr Ser Cys Lys  Pro His Gly 

    1040                 1045                 1050             





Arg Thr  Pro Leu Thr Ser Ala  Asp Glu His Val His  Ser Lys Leu 

    1055                 1060                 1065             





Glu Gly  Ser Lys Val Thr Lys  Ser Lys Thr Ser Pro  Val Val Ser 

    1070                 1075                 1080             





Gly Ser  Ser Ser Lys Ser Thr  Thr Leu Pro Arg Pro  Arg Pro Thr 

    1085                 1090                 1095             





Arg Thr  Ser Leu Leu Arg Arg  Ala Arg Leu Gly Glu  Ala Ser Asp 

    1100                 1105                 1110             





Ser Glu  Leu Ala Asp Ala Asp  Lys Ala Ser Val Ala  Ser Glu Val 

    1115                 1120                 1125             





Ser Thr  Thr Ser Ser Thr Ser  Lys Pro Pro Thr Gly  Arg Arg Asn 

    1130                 1135                 1140             





Ile Ser  Arg Ile Asp Leu Leu  Ala Gln Pro Arg Arg  Thr Arg Leu 

    1145                 1150                 1155             





Gly Ser  Leu Ser Ala Arg Ser  Asp Ser Glu Ala Thr  Ile Ser Arg 

    1160                 1165                 1170             





Ser Ser  Ala Ser Ser Arg Thr  Ala Glu Ala Ile Ile  Arg Ser Gly 

    1175                 1180                 1185             





Ala Arg  Leu Val Pro Ser Asp  Lys Phe Ser Pro Arg  Ile Arg Ala 

    1190                 1195                 1200             





Asn Ser  Ile Ser Arg Leu Ser  Asp Ser Lys Val Lys  Ser Met Thr 

    1205                 1210                 1215             





Ser Ala  His Gly Ser Ala Ser  Val Asn Ser Arg Trp  Arg Arg Phe 

    1220                 1225                 1230             





Pro Thr  Asp Tyr Ala Ser Thr  Ser Glu Asp Glu Phe  Gly Ser Asn 

    1235                 1240                 1245             





Arg Asn  Ser Pro Lys His Thr  Arg Leu Arg Thr Ser  Pro Ala Leu 

    1250                 1255                 1260             





Lys Thr  Thr Arg Leu Gln Ser  Ala Gly Ser Ala Met  Pro Thr Ser 

    1265                 1270                 1275             





Ser Ser  Phe Lys His Arg Ile  Lys Glu Gln Glu Asp  Tyr Ile Arg 

    1280                 1285                 1290             





Asp Trp  Thr Ala His Arg Glu  Glu Ile Ala Arg Ile  Ser Gln Asp 

    1295                 1300                 1305             





Leu Ala  Leu Ile Ala Arg Glu  Ile Asn Asp Val Ala  Gly Glu Ile 

    1310                 1315                 1320             





Asp Ser  Val Thr Ser Ser Gly  Thr Ala Pro Ser Thr  Thr Val Ser 

    1325                 1330                 1335             





Thr Ala  Ala Thr Thr Pro Gly  Ser Ala Ile Asp Thr  Arg Glu Glu 

    1340                 1345                 1350             





Leu Val  Asp Arg Val Phe Asp  Glu Ser Leu Asn Phe  Arg Lys Ile 

    1355                 1360                 1365             





Pro Pro  Leu Val His Ser Lys  Thr Pro Glu Gly Asn  Asn Gly Arg 

    1370                 1375                 1380             





Ser Gly  Asp Pro Arg Pro Gln  Ala Ala Glu Pro Pro  Asp His Leu 

    1385                 1390                 1395             





Thr Ile  Thr Arg Arg Arg Thr  Trp Ser Arg Asp Glu  Val Met Gly 

    1400                 1405                 1410             





Asp Asn  Leu Leu Leu Ser Ser  Val Phe Gln Phe Ser  Lys Lys Ile 

    1415                 1420                 1425             





Arg Gln  Ser Ile Asp Lys Thr  Ala Gly Lys Ile Arg  Ile Leu Phe 

    1430                 1435                 1440             





Lys Asp  Lys Asp Arg Asn Trp  Asp Asp Ile Glu Ser  Lys Leu Arg 

    1445                 1450                 1455             





Ala Glu  Ser Glu Val Pro Ile  Val Lys Thr Ser Ser  Met Glu Ile 

    1460                 1465                 1470             





Ser Ser  Ile Leu Gln Glu Leu  Lys Arg Val Glu Lys  Gln Leu Gln 

    1475                 1480                 1485             





Ala Ile  Asn Ala Met Ile Asp  Pro Asp Gly Thr Leu  Glu Ala Leu 

    1490                 1495                 1500             





Asn Asn  Met Gly Phe Pro Ser  Ala Met Leu Pro Ser  Pro Pro Lys 

    1505                 1510                 1515             





Gln Lys  Ser Ser Pro Val Asn  Asn His His Ser Pro  Gly Gln Thr 

    1520                 1525                 1530             





Pro Thr  Leu Gly Gln Pro Glu  Ala Arg Ala Leu His  Pro Ala Ala 

    1535                 1540                 1545             





Val Ser  Ala Ala Ala Glu Phe  Glu Asn Ala Glu Ser  Glu Ala Asp 

    1550                 1555                 1560             





Phe Ser  Ile His Phe Asn Arg  Phe Asn Pro Asp Gly  Glu Glu Glu 

    1565                 1570                 1575             





Asp Val  Thr Val Gln Glu 

    1580                 





<210>  73

<211>  2193

<212>  DNA

<213>  Homo sapiens



<400>  73

tatcgccgcc tcagacagct ttcagtctgt ccctcctaca actcccacaa ggcccctcgg       60



ccccgggccg cggcccggcc cggagtgggg gcgggcggag gcgcgggagt tatggagggg      120



gcgggctctg cagggaagtg cgtcagagga ggcgcgggga gagtagggtg ctgtggtctg      180



agctagaggg tgaagctggc ggagcaggag gatgggcgag cagtctgaat gccagaatgg      240



ataaccgttt tgctacagca tttgtaattg cttgtgtgct tagcctcatt tccaccatct      300



acatggcagc ctccattggc acagacttct ggtatgaata tcgaagtcca gttcaagaaa      360



attccagtga tttgaataaa agcatctggg atgaattcat tagtgatgag gcagatgaaa      420



agacttataa tgatgcactt tttcgataca atggcacagt gggattgtgg agacggtgta      480



tcaccatacc caaaaacatg cattggtata gcccaccaga aaggacagag tcatttgatg      540



tggtcacaaa atgtgtgagt ttcacactaa ctgagcagtt catggagaaa tttgttgatc      600



ccggaaacca caatagcggg attgatctcc ttaggaccta tctttggcgt tgccagttcc      660



ttttaccttt tgtgagttta ggtttgatgt gctttggggc tttgatcgga ctttgtgctt      720



gcatttgccg aagcttatat cccaccattg ccacgggcat tctccatctc cttgcaggtc      780



tgtgtacact gggctcagta agttgttatg ttgctggaat tgaactactc caccagaaac      840



tagagctccc tgacaatgta tccggtgaat ttggatggtc cttctgcctg gcttgtgtct      900



ctgctccctt acagttcatg gcttctgctc tcttcatctg ggctgctcac accaaccgga      960



aagagtacac cttaatgaag gcatatcgtg tggcatgagc aagaaactgc ctgctttaca     1020



attgccattt ttattttttt aaaataatac tgatattttc cccacctctc aattgttttt     1080



aatttttatt tgtggatata ccattttatt atgaaaatct attttattta tacacattca     1140



ccactaaata cacacttaat accactaaaa tttatgtggt ttactttaag cgatgccatc     1200



tttcaaataa actaatctag gtctagacag aaagaaatgg atagagactt gacacaaatt     1260



tatgaaagaa aattgggagt aggaatgtga ccgaaaacaa gttgtgctaa tgtctgttag     1320



acttttcagt aaaactaaag taactgtatc tgttcaacta aaaactctat attagtttct     1380



ttgggaaacc tctcatcgtc aaaactttat gttcactttg ctgttgtaga tagccagtca     1440



accagcagta ttagtgctgt tttcaaagat ttaagctcta taaaattggg aaattatcta     1500



agatcatttt ccctaagcat tgacacatag cttcatctga ggtgagatat ggcagctgtt     1560



tgtatctgca ctgtgtctgt ctacaaaaag tgaaaaatac agtgtttact tgaaatttta     1620



actttgtaac tgcaagaatt ccagttcagc cgggcgagga ttagtattat ttttaactct     1680



ccgtaagatt ttcagtacca ccaaattgtt ttggattttt tttctttcct cttcacatac     1740



cagggttatt aaaagtgtgc tttcttttta cattatatta cagttacaag gtaaaattcc     1800



tcaactgcta tttatttatt ccagcccagt actataaaga acgtttcacc ataatgaccc     1860



tccagagctg ggaaacctac cacaagatct aaagttctgg ctgtccatta acctccaact     1920



atggtcttta tttcttgtgg taatatgatg tgcctttcct tgcctaaatc ccttcctggt     1980



gtgtatcaac attatttaat gtcttctaat tcagtcattt ttttataagt atgtctataa     2040



acattgaact ttaaaaaact tatttattta ttccactact gtagcaattg acagattaaa     2100



aaaatgtaac ttcataattt cttaccataa cctcaatgtc ttttttaaaa aataaaatta     2160



aaaatgaaaa gagactcaat tgtaaaaaaa aaa                                  2193





<210>  74

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  74



Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 

1               5                   10                  15      





Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 

            20                  25                  30          





Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 

        35                  40                  45              





Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 

    50                  55                  60                  





Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 

65                  70                  75                  80  





Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 

                85                  90                  95      





Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 

            100                 105                 110         





Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 

        115                 120                 125             





Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 

    130                 135                 140                 





Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 

145                 150                 155                 160 





Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 

                165                 170                 175     





His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 

            180                 185                 190         





Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 

        195                 200                 205             





Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 

    210                 215                 220                 





Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 

225                 230                 235                 240 





Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 

                245                 250             





<210>  75

<211>  2237

<212>  DNA

<213>  Homo sapiens



<400>  75

tatcgccgcc tcagacagct ttcagtctgt ccctcctaca actcccacaa ggcccctcgg       60



ccccgggccg cggcccggcc cggagtgggg gcgggcggag gcgcgggagt tatggagggg      120



gcgggctctg cagggaagtg cgtcagagga ggcgcgggga gagtagggtg ctgtggtctg      180



agctagaggg tgaagctggc ggagcaggag gatgggcggt gatagactag agaacaagac      240



ctctgtctcc gtagcatcct ggagcagtct gaatgccaga atggataacc gttttgctac      300



agcatttgta attgcttgtg tgcttagcct catttccacc atctacatgg cagcctccat      360



tggcacagac ttctggtatg aatatcgaag tccagttcaa gaaaattcca gtgatttgaa      420



taaaagcatc tgggatgaat tcattagtga tgaggcagat gaaaagactt ataatgatgc      480



actttttcga tacaatggca cagtgggatt gtggagacgg tgtatcacca tacccaaaaa      540



catgcattgg tatagcccac cagaaaggac agagtcattt gatgtggtca caaaatgtgt      600



gagtttcaca ctaactgagc agttcatgga gaaatttgtt gatcccggaa accacaatag      660



cgggattgat ctccttagga cctatctttg gcgttgccag ttccttttac cttttgtgag      720



tttaggtttg atgtgctttg gggctttgat cggactttgt gcttgcattt gccgaagctt      780



atatcccacc attgccacgg gcattctcca tctccttgca ggtctgtgta cactgggctc      840



agtaagttgt tatgttgctg gaattgaact actccaccag aaactagagc tccctgacaa      900



tgtatccggt gaatttggat ggtccttctg cctggcttgt gtctctgctc ccttacagtt      960



catggcttct gctctcttca tctgggctgc tcacaccaac cggaaagagt acaccttaat     1020



gaaggcatat cgtgtggcat gagcaagaaa ctgcctgctt tacaattgcc atttttattt     1080



ttttaaaata atactgatat tttccccacc tctcaattgt ttttaatttt tatttgtgga     1140



tataccattt tattatgaaa atctatttta tttatacaca ttcaccacta aatacacact     1200



taataccact aaaatttatg tggtttactt taagcgatgc catctttcaa ataaactaat     1260



ctaggtctag acagaaagaa atggatagag acttgacaca aatttatgaa agaaaattgg     1320



gagtaggaat gtgaccgaaa acaagttgtg ctaatgtctg ttagactttt cagtaaaact     1380



aaagtaactg tatctgttca actaaaaact ctatattagt ttctttggga aacctctcat     1440



cgtcaaaact ttatgttcac tttgctgttg tagatagcca gtcaaccagc agtattagtg     1500



ctgttttcaa agatttaagc tctataaaat tgggaaatta tctaagatca ttttccctaa     1560



gcattgacac atagcttcat ctgaggtgag atatggcagc tgtttgtatc tgcactgtgt     1620



ctgtctacaa aaagtgaaaa atacagtgtt tacttgaaat tttaactttg taactgcaag     1680



aattccagtt cagccgggcg aggattagta ttatttttaa ctctccgtaa gattttcagt     1740



accaccaaat tgttttggat tttttttctt tcctcttcac ataccagggt tattaaaagt     1800



gtgctttctt tttacattat attacagtta caaggtaaaa ttcctcaact gctatttatt     1860



tattccagcc cagtactata aagaacgttt caccataatg accctccaga gctgggaaac     1920



ctaccacaag atctaaagtt ctggctgtcc attaacctcc aactatggtc tttatttctt     1980



gtggtaatat gatgtgcctt tccttgccta aatcccttcc tggtgtgtat caacattatt     2040



taatgtcttc taattcagtc atttttttat aagtatgtct ataaacattg aactttaaaa     2100



aacttattta tttattccac tactgtagca attgacagat taaaaaaatg taacttcata     2160



atttcttacc ataacctcaa tgtctttttt aaaaaataaa attaaaaatg aaaagagact     2220



caattgtaaa aaaaaaa                                                    2237





<210>  76

<211>  276

<212>  PRT

<213>  Homo sapiens



<400>  76



Met Gly Gly Asp Arg Leu Glu Asn Lys Thr Ser Val Ser Val Ala Ser 

1               5                   10                  15      





Trp Ser Ser Leu Asn Ala Arg Met Asp Asn Arg Phe Ala Thr Ala Phe 

            20                  25                  30          





Val Ile Ala Cys Val Leu Ser Leu Ile Ser Thr Ile Tyr Met Ala Ala 

        35                  40                  45              





Ser Ile Gly Thr Asp Phe Trp Tyr Glu Tyr Arg Ser Pro Val Gln Glu 

    50                  55                  60                  





Asn Ser Ser Asp Leu Asn Lys Ser Ile Trp Asp Glu Phe Ile Ser Asp 

65                  70                  75                  80  





Glu Ala Asp Glu Lys Thr Tyr Asn Asp Ala Leu Phe Arg Tyr Asn Gly 

                85                  90                  95      





Thr Val Gly Leu Trp Arg Arg Cys Ile Thr Ile Pro Lys Asn Met His 

            100                 105                 110         





Trp Tyr Ser Pro Pro Glu Arg Thr Glu Ser Phe Asp Val Val Thr Lys 

        115                 120                 125             





Cys Val Ser Phe Thr Leu Thr Glu Gln Phe Met Glu Lys Phe Val Asp 

    130                 135                 140                 





Pro Gly Asn His Asn Ser Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp 

145                 150                 155                 160 





Arg Cys Gln Phe Leu Leu Pro Phe Val Ser Leu Gly Leu Met Cys Phe 

                165                 170                 175     





Gly Ala Leu Ile Gly Leu Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro 

            180                 185                 190         





Thr Ile Ala Thr Gly Ile Leu His Leu Leu Ala Gly Leu Cys Thr Leu 

        195                 200                 205             





Gly Ser Val Ser Cys Tyr Val Ala Gly Ile Glu Leu Leu His Gln Lys 

    210                 215                 220                 





Leu Glu Leu Pro Asp Asn Val Ser Gly Glu Phe Gly Trp Ser Phe Cys 

225                 230                 235                 240 





Leu Ala Cys Val Ser Ala Pro Leu Gln Phe Met Ala Ser Ala Leu Phe 

                245                 250                 255     





Ile Trp Ala Ala His Thr Asn Arg Lys Glu Tyr Thr Leu Met Lys Ala 

            260                 265                 270         





Tyr Arg Val Ala 

        275     





<210>  77

<211>  2188

<212>  DNA

<213>  Homo sapiens



<400>  77

tatcgccgcc tcagacagct ttcagtctgt ccctcctaca actcccacaa ggcccctcgg       60



ccccgggccg cggcccggcc cggagtgggg gcgggcggag gcgcgggagt tatggagggg      120



gcgggctctg cagggaagtg cgtcagagga ggcgcgggga gagtagggtg ctgtggtctg      180



agctagaggg tgaagctggc ggagcaggag gatgggcgtc tgaatgccag aatggataac      240



cgttttgcta cagcatttgt aattgcttgt gtgcttagcc tcatttccac catctacatg      300



gcagcctcca ttggcacaga cttctggtat gaatatcgaa gtccagttca agaaaattcc      360



agtgatttga ataaaagcat ctgggatgaa ttcattagtg atgaggcaga tgaaaagact      420



tataatgatg cactttttcg atacaatggc acagtgggat tgtggagacg gtgtatcacc      480



atacccaaaa acatgcattg gtatagccca ccagaaagga cagagtcatt tgatgtggtc      540



acaaaatgtg tgagtttcac actaactgag cagttcatgg agaaatttgt tgatcccgga      600



aaccacaata gcgggattga tctccttagg acctatcttt ggcgttgcca gttcctttta      660



ccttttgtga gtttaggttt gatgtgcttt ggggctttga tcggactttg tgcttgcatt      720



tgccgaagct tatatcccac cattgccacg ggcattctcc atctccttgc aggtctgtgt      780



acactgggct cagtaagttg ttatgttgct ggaattgaac tactccacca gaaactagag      840



ctccctgaca atgtatccgg tgaatttgga tggtccttct gcctggcttg tgtctctgct      900



cccttacagt tcatggcttc tgctctcttc atctgggctg ctcacaccaa ccggaaagag      960



tacaccttaa tgaaggcata tcgtgtggca tgagcaagaa actgcctgct ttacaattgc     1020



catttttatt tttttaaaat aatactgata ttttccccac ctctcaattg tttttaattt     1080



ttatttgtgg atataccatt ttattatgaa aatctatttt atttatacac attcaccact     1140



aaatacacac ttaataccac taaaatttat gtggtttact ttaagcgatg ccatctttca     1200



aataaactaa tctaggtcta gacagaaaga aatggataga gacttgacac aaatttatga     1260



aagaaaattg ggagtaggaa tgtgaccgaa aacaagttgt gctaatgtct gttagacttt     1320



tcagtaaaac taaagtaact gtatctgttc aactaaaaac tctatattag tttctttggg     1380



aaacctctca tcgtcaaaac tttatgttca ctttgctgtt gtagatagcc agtcaaccag     1440



cagtattagt gctgttttca aagatttaag ctctataaaa ttgggaaatt atctaagatc     1500



attttcccta agcattgaca catagcttca tctgaggtga gatatggcag ctgtttgtat     1560



ctgcactgtg tctgtctaca aaaagtgaaa aatacagtgt ttacttgaaa ttttaacttt     1620



gtaactgcaa gaattccagt tcagccgggc gaggattagt attattttta actctccgta     1680



agattttcag taccaccaaa ttgttttgga ttttttttct ttcctcttca cataccaggg     1740



ttattaaaag tgtgctttct ttttacatta tattacagtt acaaggtaaa attcctcaac     1800



tgctatttat ttattccagc ccagtactat aaagaacgtt tcaccataat gaccctccag     1860



agctgggaaa cctaccacaa gatctaaagt tctggctgtc cattaacctc caactatggt     1920



ctttatttct tgtggtaata tgatgtgcct ttccttgcct aaatcccttc ctggtgtgta     1980



tcaacattat ttaatgtctt ctaattcagt cattttttta taagtatgtc tataaacatt     2040



gaactttaaa aaacttattt atttattcca ctactgtagc aattgacaga ttaaaaaaat     2100



gtaacttcat aatttcttac cataacctca atgtcttttt taaaaaataa aattaaaaat     2160



gaaaagagac tcaattgtaa aaaaaaaa                                        2188





<210>  78

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  78



Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 

1               5                   10                  15      





Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 

            20                  25                  30          





Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 

        35                  40                  45              





Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 

    50                  55                  60                  





Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 

65                  70                  75                  80  





Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 

                85                  90                  95      





Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 

            100                 105                 110         





Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 

        115                 120                 125             





Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 

    130                 135                 140                 





Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 

145                 150                 155                 160 





Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 

                165                 170                 175     





His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 

            180                 185                 190         





Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 

        195                 200                 205             





Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 

    210                 215                 220                 





Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 

225                 230                 235                 240 





Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 

                245                 250             





<210>  79

<211>  2500

<212>  DNA

<213>  Homo sapiens



<400>  79

tatcgccgcc tcagacagct ttcagtctgt ccctcctaca actcccacaa ggcccctcgg       60



ccccgggccg cggcccggcc cggagtgggg gcgggcggag gcgcgggagt tatggagggg      120



gcgggctctg cagggaagtg cgtcagagga ggcgcgggga gagtagggtg ctgtggtctg      180



agctagaggg tgaagctggc ggagcaggag gatgggcggt gagtgagcgg gacctgcgtc      240



gccgggcagg ggtcgcgtcg cggttccatg ttcccggcgg tttgaagagg ggcccccttc      300



ccgggcgtgg tcgggctggg cgggttccga gcggcggatt tgtcccaggg ccgagccctc      360



tagggcgggg cctggtcggg taccggggga ccctggcccg gggccgagca cggctgcccc      420



gccccagccc tggccttctc cggccccgcc gtgaggccca ggaggtggct gctgcaggcg      480



tccggcttgg acgaaccgcc gttcccagtg ctgggaccct ttaagagcag tctgaatgcc      540



agaatggata accgttttgc tacagcattt gtaattgctt gtgtgcttag cctcatttcc      600



accatctaca tggcagcctc cattggcaca gacttctggt atgaatatcg aagtccagtt      660



caagaaaatt ccagtgattt gaataaaagc atctgggatg aattcattag tgatgaggca      720



gatgaaaaga cttataatga tgcacttttt cgatacaatg gcacagtggg attgtggaga      780



cggtgtatca ccatacccaa aaacatgcat tggtatagcc caccagaaag gacagagtca      840



tttgatgtgg tcacaaaatg tgtgagtttc acactaactg agcagttcat ggagaaattt      900



gttgatcccg gaaaccacaa tagcgggatt gatctcctta ggacctatct ttggcgttgc      960



cagttccttt taccttttgt gagtttaggt ttgatgtgct ttggggcttt gatcggactt     1020



tgtgcttgca tttgccgaag cttatatccc accattgcca cgggcattct ccatctcctt     1080



gcaggtctgt gtacactggg ctcagtaagt tgttatgttg ctggaattga actactccac     1140



cagaaactag agctccctga caatgtatcc ggtgaatttg gatggtcctt ctgcctggct     1200



tgtgtctctg ctcccttaca gttcatggct tctgctctct tcatctgggc tgctcacacc     1260



aaccggaaag agtacacctt aatgaaggca tatcgtgtgg catgagcaag aaactgcctg     1320



ctttacaatt gccattttta tttttttaaa ataatactga tattttcccc acctctcaat     1380



tgtttttaat ttttatttgt ggatatacca ttttattatg aaaatctatt ttatttatac     1440



acattcacca ctaaatacac acttaatacc actaaaattt atgtggttta ctttaagcga     1500



tgccatcttt caaataaact aatctaggtc tagacagaaa gaaatggata gagacttgac     1560



acaaatttat gaaagaaaat tgggagtagg aatgtgaccg aaaacaagtt gtgctaatgt     1620



ctgttagact tttcagtaaa actaaagtaa ctgtatctgt tcaactaaaa actctatatt     1680



agtttctttg ggaaacctct catcgtcaaa actttatgtt cactttgctg ttgtagatag     1740



ccagtcaacc agcagtatta gtgctgtttt caaagattta agctctataa aattgggaaa     1800



ttatctaaga tcattttccc taagcattga cacatagctt catctgaggt gagatatggc     1860



agctgtttgt atctgcactg tgtctgtcta caaaaagtga aaaatacagt gtttacttga     1920



aattttaact ttgtaactgc aagaattcca gttcagccgg gcgaggatta gtattatttt     1980



taactctccg taagattttc agtaccacca aattgttttg gatttttttt ctttcctctt     2040



cacataccag ggttattaaa agtgtgcttt ctttttacat tatattacag ttacaaggta     2100



aaattcctca actgctattt atttattcca gcccagtact ataaagaacg tttcaccata     2160



atgaccctcc agagctggga aacctaccac aagatctaaa gttctggctg tccattaacc     2220



tccaactatg gtctttattt cttgtggtaa tatgatgtgc ctttccttgc ctaaatccct     2280



tcctggtgtg tatcaacatt atttaatgtc ttctaattca gtcatttttt tataagtatg     2340



tctataaaca ttgaacttta aaaaacttat ttatttattc cactactgta gcaattgaca     2400



gattaaaaaa atgtaacttc ataatttctt accataacct caatgtcttt tttaaaaaat     2460



aaaattaaaa atgaaaagag actcaattgt aaaaaaaaaa                           2500





<210>  80

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  80



Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 

1               5                   10                  15      





Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 

            20                  25                  30          





Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 

        35                  40                  45              





Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 

    50                  55                  60                  





Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 

65                  70                  75                  80  





Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 

                85                  90                  95      





Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 

            100                 105                 110         





Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 

        115                 120                 125             





Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 

    130                 135                 140                 





Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 

145                 150                 155                 160 





Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 

                165                 170                 175     





His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 

            180                 185                 190         





Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 

        195                 200                 205             





Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 

    210                 215                 220                 





Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 

225                 230                 235                 240 





Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 

                245                 250             





<210>  81

<211>  1883

<212>  DNA

<213>  Homo sapiens



<400>  81

tatcgccgcc tcagacagct ttcagtctgt ccctcctaca actcccacaa ggcccctcgg       60



ccccgggccg cggcccggcc cggagtgggg gcgggcggag gcgcgggagt tatggagggg      120



gcgggctctg cagggaagtg cgtcagagga ggcgcgggga gagtagggtg ctgtggtctg      180



agctagaggg tgaagctggc ggagcaggag gatgggcgag tcatttgatg tggtcacaaa      240



atgtgtgagt ttcacactaa ctgagcagtt catggagaaa tttgttgatc ccggaaacca      300



caatagcggg attgatctcc ttaggaccta tctttggcgt tgccagttcc ttttaccttt      360



tgtgagttta ggtttgatgt gctttggggc tttgatcgga ctttgtgctt gcatttgccg      420



aagcttatat cccaccattg ccacgggcat tctccatctc cttgcaggtc tgtgtacact      480



gggctcagta agttgttatg ttgctggaat tgaactactc caccagaaac tagagctccc      540



tgacaatgta tccggtgaat ttggatggtc cttctgcctg gcttgtgtct ctgctccctt      600



acagttcatg gcttctgctc tcttcatctg ggctgctcac accaaccgga aagagtacac      660



cttaatgaag gcatatcgtg tggcatgagc aagaaactgc ctgctttaca attgccattt      720



ttattttttt aaaataatac tgatattttc cccacctctc aattgttttt aatttttatt      780



tgtggatata ccattttatt atgaaaatct attttattta tacacattca ccactaaata      840



cacacttaat accactaaaa tttatgtggt ttactttaag cgatgccatc tttcaaataa      900



actaatctag gtctagacag aaagaaatgg atagagactt gacacaaatt tatgaaagaa      960



aattgggagt aggaatgtga ccgaaaacaa gttgtgctaa tgtctgttag acttttcagt     1020



aaaactaaag taactgtatc tgttcaacta aaaactctat attagtttct ttgggaaacc     1080



tctcatcgtc aaaactttat gttcactttg ctgttgtaga tagccagtca accagcagta     1140



ttagtgctgt tttcaaagat ttaagctcta taaaattggg aaattatcta agatcatttt     1200



ccctaagcat tgacacatag cttcatctga ggtgagatat ggcagctgtt tgtatctgca     1260



ctgtgtctgt ctacaaaaag tgaaaaatac agtgtttact tgaaatttta actttgtaac     1320



tgcaagaatt ccagttcagc cgggcgagga ttagtattat ttttaactct ccgtaagatt     1380



ttcagtacca ccaaattgtt ttggattttt tttctttcct cttcacatac cagggttatt     1440



aaaagtgtgc tttcttttta cattatatta cagttacaag gtaaaattcc tcaactgcta     1500



tttatttatt ccagcccagt actataaaga acgtttcacc ataatgaccc tccagagctg     1560



ggaaacctac cacaagatct aaagttctgg ctgtccatta acctccaact atggtcttta     1620



tttcttgtgg taatatgatg tgcctttcct tgcctaaatc ccttcctggt gtgtatcaac     1680



attatttaat gtcttctaat tcagtcattt ttttataagt atgtctataa acattgaact     1740



ttaaaaaact tatttattta ttccactact gtagcaattg acagattaaa aaaatgtaac     1800



ttcataattt cttaccataa cctcaatgtc ttttttaaaa aataaaatta aaaatgaaaa     1860



gagactcaat tgtaaaaaaa aaa                                             1883





<210>  82

<211>  158

<212>  PRT

<213>  Homo sapiens



<400>  82



Met Gly Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu 

1               5                   10                  15      





Thr Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser 

            20                  25                  30          





Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu 

        35                  40                  45              





Pro Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu 

    50                  55                  60                  





Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile 

65                  70                  75                  80  





Leu His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr 

                85                  90                  95      





Val Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn 

            100                 105                 110         





Val Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala 

        115                 120                 125             





Pro Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr 

    130                 135                 140                 





Asn Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 

145                 150                 155             





<210>  83

<211>  2244

<212>  DNA

<213>  Homo sapiens



<400>  83

tatcgccgcc tcagacagct ttcagtctgt ccctcctaca actcccacaa ggcccctcgg       60



ccccgggccg cggcccggcc cggagtgggg gcgggcggag gcgcgggagt tatggagggg      120



gcgggctctg cagggaagtg cgtcagagga ggcgcgggga gagtagggtg ctgtggtctg      180



agctagaggg tgaagctggc ggagcaggag gatgggcgta tgcaggtgat agactagaga      240



acaagacctc tgtctccgta gcatcctgga gcagtctgaa tgccagaatg gataaccgtt      300



ttgctacagc atttgtaatt gcttgtgtgc ttagcctcat ttccaccatc tacatggcag      360



cctccattgg cacagacttc tggtatgaat atcgaagtcc agttcaagaa aattccagtg      420



atttgaataa aagcatctgg gatgaattca ttagtgatga ggcagatgaa aagacttata      480



atgatgcact ttttcgatac aatggcacag tgggattgtg gagacggtgt atcaccatac      540



ccaaaaacat gcattggtat agcccaccag aaaggacaga gtcatttgat gtggtcacaa      600



aatgtgtgag tttcacacta actgagcagt tcatggagaa atttgttgat cccggaaacc      660



acaatagcgg gattgatctc cttaggacct atctttggcg ttgccagttc cttttacctt      720



ttgtgagttt aggtttgatg tgctttgggg ctttgatcgg actttgtgct tgcatttgcc      780



gaagcttata tcccaccatt gccacgggca ttctccatct ccttgcaggt ctgtgtacac      840



tgggctcagt aagttgttat gttgctggaa ttgaactact ccaccagaaa ctagagctcc      900



ctgacaatgt atccggtgaa tttggatggt ccttctgcct ggcttgtgtc tctgctccct      960



tacagttcat ggcttctgct ctcttcatct gggctgctca caccaaccgg aaagagtaca     1020



ccttaatgaa ggcatatcgt gtggcatgag caagaaactg cctgctttac aattgccatt     1080



tttatttttt taaaataata ctgatatttt ccccacctct caattgtttt taatttttat     1140



ttgtggatat accattttat tatgaaaatc tattttattt atacacattc accactaaat     1200



acacacttaa taccactaaa atttatgtgg tttactttaa gcgatgccat ctttcaaata     1260



aactaatcta ggtctagaca gaaagaaatg gatagagact tgacacaaat ttatgaaaga     1320



aaattgggag taggaatgtg accgaaaaca agttgtgcta atgtctgtta gacttttcag     1380



taaaactaaa gtaactgtat ctgttcaact aaaaactcta tattagtttc tttgggaaac     1440



ctctcatcgt caaaacttta tgttcacttt gctgttgtag atagccagtc aaccagcagt     1500



attagtgctg ttttcaaaga tttaagctct ataaaattgg gaaattatct aagatcattt     1560



tccctaagca ttgacacata gcttcatctg aggtgagata tggcagctgt ttgtatctgc     1620



actgtgtctg tctacaaaaa gtgaaaaata cagtgtttac ttgaaatttt aactttgtaa     1680



ctgcaagaat tccagttcag ccgggcgagg attagtatta tttttaactc tccgtaagat     1740



tttcagtacc accaaattgt tttggatttt ttttctttcc tcttcacata ccagggttat     1800



taaaagtgtg ctttcttttt acattatatt acagttacaa ggtaaaattc ctcaactgct     1860



atttatttat tccagcccag tactataaag aacgtttcac cataatgacc ctccagagct     1920



gggaaaccta ccacaagatc taaagttctg gctgtccatt aacctccaac tatggtcttt     1980



atttcttgtg gtaatatgat gtgcctttcc ttgcctaaat cccttcctgg tgtgtatcaa     2040



cattatttaa tgtcttctaa ttcagtcatt tttttataag tatgtctata aacattgaac     2100



tttaaaaaac ttatttattt attccactac tgtagcaatt gacagattaa aaaaatgtaa     2160



cttcataatt tcttaccata acctcaatgt cttttttaaa aaataaaatt aaaaatgaaa     2220



agagactcaa ttgtaaaaaa aaaa                                            2244





<210>  84

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  84



Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 

1               5                   10                  15      





Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 

            20                  25                  30          





Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 

        35                  40                  45              





Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 

    50                  55                  60                  





Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 

65                  70                  75                  80  





Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 

                85                  90                  95      





Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 

            100                 105                 110         





Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 

        115                 120                 125             





Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 

    130                 135                 140                 





Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 

145                 150                 155                 160 





Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 

                165                 170                 175     





His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 

            180                 185                 190         





Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 

        195                 200                 205             





Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 

    210                 215                 220                 





Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 

225                 230                 235                 240 





Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 

                245                 250             





<210>  85

<211>  4452

<212>  DNA

<213>  Homo sapiens



<400>  85

ttattttccc cggagagtcc cgaggcgccg cgccttggcc ctgcctacag cccgaggccc       60



cgcccccggc gcccctccca gccgtttgaa gcggctcggg ctgcggctgg ctcagagtgg      120



cgcggggggc gtggggcggt gctgaggagc tgaagccgtg gccagctcga cgccggacag      180



tccagcgagc agcacggcgg gaaccggcag ccggagcagt cccggagcag aagcagcagc      240



agcagcagca gccctcgccg ttcgcggagc gcagccgagc cggccatggc gttgtcgatg      300



ccgctgaatg ggctgaagga ggaggacaaa gagcccctca tcgagctctt cgtcaaggct      360



ggcagtgatg gtgaaagcat aggaaactgc cccttttccc agaggctctt catgattctt      420



tggctcaaag gagttgtatt tagtgtgacg actgttgacc tgaaaaggaa gccagcagac      480



ctgcagaact tggctcccgg gacccaccca ccatttataa ctttcaacag tgaagtcaaa      540



acggatgtaa ataagattga ggaatttctt gaagaagtct tatgccctcc caagtactta      600



aagctttcac caaaacaccc agaatcaaat actgctggaa tggacatctt tgccaaattc      660



tctgcatata tcaagaattc aaggccagag gctaatgaag cactggagag gggtctcctg      720



aaaaccctgc agaaactgga tgaatatctg aattctcctc tccctgatga aattgatgaa      780



aatagtatgg aggacataaa gttttctaca cgtaaatttc tggatggcaa tgaaatgaca      840



ttagctgatt gcaacctgct gcccaaactg catattgtca aggtggtggc caaaaaatat      900



cgcaactttg atattccaaa agaaatgact ggcatctgga gatacctaac taatgcatac      960



agtagggacg agttcaccaa tacctgtccc agtgataagg aggttgaaat agcatatagt     1020



gatgtagcca aaagactcac caagtaaaat cgcgtttgta aaagagatgt cttcatgtct     1080



tcccctaaga atacgctttt cctaacaggc tactccttcc tgtagagcag aaattgtatt     1140



ttgcacgaac atgcagttat tgaagattag gatcaaggat agacaaggta tagtagttat     1200



cttaaaatat acactcctaa gcagtattat tttaaaatcc tttaccctgg ctacctcccc     1260



tacccgggtt cccctctctt taatttggag acactccacc acaaactttt cactttagag     1320



gtagcttgcc atctctcagg agccctcacc attgtgtcca ttcactgtgt atagatggca     1380



gaacttttga ggtgcaatgt ttaattgtta aaaatagtag ccacgacttt atcaggcagc     1440



cccaaactgg tgcataatgc atggtacaag aaatatttat gtattttttg gaattttgta     1500



atatttagta agagtatatg aaaggattgc tactgtatca gaaatattgt ttcaatttag     1560



tctatcctgg atatgtacta acgaatatta ccaccagaga agagagcttt ctacaaaagt     1620



cactacagat tttgctatat tgctttgtag atagattttt acttttgcct aaaagcattt     1680



atccttcata ccaattgtaa catctgacac catgtagaag ctaaaagttt agagggagtg     1740



agggttttct caagaccttc ctcaagcatt ttatctttag aagagaaact gatgggcacc     1800



tgatactctg tctaaatacg tttgttatat gtgttttgcc ctgtgccatt catttggaac     1860



tttattgcat tctttatttt aaaaagcttg tttttacgta atcatagagc ttgctatttg     1920



tacatctgtt gagcaacact acataactga tttttagttg acttagctat agcagtacaa     1980



tgattagtaa tgtaaaaatt aacacagaaa ttaacctaag gaatgaaggg tgggtttgtc     2040



aaaatatcaa gtaaattttt gtttctaaag tacatttaat gtagatgacc taaagaatgc     2100



gttatccatc ctatataaaa gaaagataaa acacaggtca ccaattttct catttcaccc     2160



catttacctt gtatagagga ttgttcattc ctttgggact aagttatagt tatggtgagt     2220



gtgtatttac tgtagttttg cctgatctca ctcattgcac ttcctggagt taaattttcc     2280



aacagccatg ttgaggaata gcactctgca tgtttttgtt ttgtttttcg gggttttttt     2340



taattgaagc cctaaaccag gaattatttg tgttctaaca ggaggatgaa cttgctgaaa     2400



ataaaacttt gctatgtatt tactcttttt taaaagacaa aagcaaaacc agactttcta     2460



cgtactactc caaagactgt gattgtgact ataatacatt tttggtaatt tttttatacc     2520



taatttgtat aggaagtgct atttctcata ggctgtttct tgaaatttta agtttattgc     2580



tttaaaatgg cagtgtttct cccactttga tatgctaaca tttagtaagc actggcttta     2640



tgaaagcggc tttttataag tatactgcat tttttgagcc tatcattaat tagcttagta     2700



tgaaagataa gaaaatctcc atgttgtatc catttggctc aggaagattc tttgccttac     2760



ctttcttaga actctttatt gcttatcaaa agtttgagta cccgcttggt ttttttttgg     2820



taattaaata ttgtatgatt tatctggttc aaggaagatg cactattcag ttatctattg     2880



agaaattatt ttgcagtggt tttagtgggt gaaaatgtcc catctgcacc agtacacagg     2940



caggcattat cattcttcac ctacttttta aatagtggca acttgggatt cattctggtg     3000



attctgaacc ttgcctcata gcttaaagta taaaaaagat tcaagagcag tgaggtttgt     3060



tctttccagt gaatggtgga ctgagtggtg cgaggtggag ggctaacaag aggaaagaac     3120



tacattcttc agaatacagt gatgaaaatt cattttgaaa ctcaaatatt ttcattttgg     3180



atattctcct gtttttatta aaccagtgat tacacctggc catccctcta aatgttctag     3240



gaaggcatgt ctattgtgat tttgatgaag acagaattat ttttctctgt agaaacacag     3300



ataccacttt atcagggaag ttagtcaaat gaaatggaaa ttggtaaatg gacaaaagct     3360



agctagtaaa aaggacgacc cagcaacatg ctttaacccc attgtatgtt tgtggaaaga     3420



gcatagttta acatcttgag aaatttggga cataaagttt tcatggtaga cagttcatgc     3480



agtatatgaa ttgccataat ggaaataatc tgattttatt tttacaacta acatccattc     3540



cccttcattt aaacaccttt tgtgttttac ttcagtgagg agattggagt ctgaatggat     3600



ctgttttcca agagattctg agaaattttt gtattcagca gttggaaagc tctctattct     3660



agttgataaa acttcccttt tttgatgtag atgcagatat tctatacagt tctgttgtct     3720



tttactagga ctgtaaactt ttgtgataaa attcaaataa gattttattt cttggtaatt     3780



ttggctttca caatttatct ttaaatcctt gagcaatctg tatacaatta agagatttct     3840



gacatttatt cttacactaa atggatcaac tctaggattt aggcatgtta acttctgttg     3900



tgttttgaat ctctccagag ttgcatgtag atagcattta tttctgtgcc cttaaaccca     3960



tttagaaaat aactacaaag taaaaatgta gaggaaatag aaatgtattt tttcatgaac     4020



attttgatac aaatttcatc atttaatgat tcaccaattt cttgcattaa tttgaattta     4080



agcatttaat tcaaagagag gggagcatcc attattgata catgtgggct tttaaaaact     4140



ccatccttta taaatagtca aggtttgggc cacacaaagt atatttttat catggaaaaa     4200



tttcaactcc tcaagccgta atgttgaaca gaattggagt attttcttta taatttcttg     4260



aacaggcaaa tgaaagctta ttatagaatg catgtatttt cttttatctt tggaacatca     4320



gcaccagtat attgctggca gctattgtat taaaaaataa agtatatttt cactatcata     4380



aaggattctt ttttcccccc tcatgaaaat aaacaacaac ttggggtaaa agtgaaaaaa     4440



aaaaaaaaaa aa                                                         4452





<210>  86

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  86



Met Ala Leu Ser Met Pro Leu Asn Gly Leu Lys Glu Glu Asp Lys Glu 

1               5                   10                  15      





Pro Leu Ile Glu Leu Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile 

            20                  25                  30          





Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp Leu Lys 

        35                  40                  45              





Gly Val Val Phe Ser Val Thr Thr Val Asp Leu Lys Arg Lys Pro Ala 

    50                  55                  60                  





Asp Leu Gln Asn Leu Ala Pro Gly Thr His Pro Pro Phe Ile Thr Phe 

65                  70                  75                  80  





Asn Ser Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe Leu Glu 

                85                  90                  95      





Glu Val Leu Cys Pro Pro Lys Tyr Leu Lys Leu Ser Pro Lys His Pro 

            100                 105                 110         





Glu Ser Asn Thr Ala Gly Met Asp Ile Phe Ala Lys Phe Ser Ala Tyr 

        115                 120                 125             





Ile Lys Asn Ser Arg Pro Glu Ala Asn Glu Ala Leu Glu Arg Gly Leu 

    130                 135                 140                 





Leu Lys Thr Leu Gln Lys Leu Asp Glu Tyr Leu Asn Ser Pro Leu Pro 

145                 150                 155                 160 





Asp Glu Ile Asp Glu Asn Ser Met Glu Asp Ile Lys Phe Ser Thr Arg 

                165                 170                 175     





Lys Phe Leu Asp Gly Asn Glu Met Thr Leu Ala Asp Cys Asn Leu Leu 

            180                 185                 190         





Pro Lys Leu His Ile Val Lys Val Val Ala Lys Lys Tyr Arg Asn Phe 

        195                 200                 205             





Asp Ile Pro Lys Glu Met Thr Gly Ile Trp Arg Tyr Leu Thr Asn Ala 

    210                 215                 220                 





Tyr Ser Arg Asp Glu Phe Thr Asn Thr Cys Pro Ser Asp Lys Glu Val 

225                 230                 235                 240 





Glu Ile Ala Tyr Ser Asp Val Ala Lys Arg Leu Thr Lys 

                245                 250             





<210>  87

<211>  5398

<212>  DNA

<213>  Homo sapiens



<400>  87

cgcggcggag gaggcagcat cccgcggcgc tgacggtcct ggggagagca tggcgccgag       60



gtgcccctgg ccatggccgc ggcggcggcg cctcctggac gtgctcgcgc ccctggtcct      120



gctgctcggg gtccgcgcgg cctccgcgga gccagagcgc atcagcgagg aggtggggct      180



gctgcagctc cttggggacc ccccgcccca gcaggtcacc cagacggatg accccgacgt      240



cgggctggcc tacgtctttg ggccagatgc caacagtggc caagtggccc ggtaccactt      300



ccccagcctc ttcttccgtg acttctcact gctgttccac atccggccag ccacagaggg      360



cccaggggtg ctgttcgcca tcacggactc ggcgcaggcc atggtcttgc tgggcgtgaa      420



gctctctggg gtgcaggacg ggcaccagga catctccctg ctctacacag aaccaggtgc      480



aggccagacc cacacagccg ccagcttccg gctccccgcc ttcgtcggcc agtggacaca      540



cttagccctc agtgtggcag gtggctttgt ggccctctac gtggactgtg aggagttcca      600



gagaatgccg cttgctcggt cctcacgggg cctggagctg gagcctggcg ccgggctctt      660



cgtggctcag gcggggggag cggaccctga caagttccag ggggtgatcg ctgagctgaa      720



ggtgcgcagg gacccccagg tgagccccat gcactgcctg gacgaggaag gcgatgactc      780



agatggggca tccggagact ctggcagcgg gctcggggac gcccgggagc ttctcaggga      840



ggagacgggc gcggccctaa aacccaggct ccccgcgcca ccccccgtca ccacgccacc      900



cttggctgga ggcagcagca cggaagattc cagaagtgaa gaagtcgagg agcagaccac      960



ggtggcttcg ttaggagctc agacacttcc tggctcagat tctgtctcca cgtgggacgg     1020



gagtgtccgg acccctgggg gccgcgtgaa agagggcggc ctgaaggggc agaaagggga     1080



gccaggtgtt ccgggcccac ctggccgggc aggcccccca ggatccccat gcctacctgg     1140



tcccccgggt ctcccgtgcc cagtgagtcc cctgggtcct gcaggcccag cgttgcaaac     1200



tgtccccgga ccacaaggac ccccagggcc tccggggagg gacggcaccc ctggaaggga     1260



cggcgagccg ggcgaccccg gtgaagacgg aaagccgggc gacaccgggc cacaaggctt     1320



ccccgggact ccaggggacg taggtcccaa gggcgacaag ggagaccctg gggttggaga     1380



gagagggccc ccaggacccc aagggcctcc agggccccca ggaccctcct tcagacacga     1440



caagctgacc ttcattgaca tggagggatc tggcttcggg ggcgatctgg aggccctgcg     1500



gggtcctcga ggcttccctg gacctcccgg accccccggt gtcccaggcc tgcccggcga     1560



gccaggccgc tttggggtga acagctccga cgtcccagga cccgccggcc ttcctggtgt     1620



gcctgggcgc gagggtcccc ccgggtttcc tggcctcccg ggacccccag gccctccggg     1680



aagagagggg cccccaggaa ggactgggca gaaaggcagc ctgggtgaag caggcgcccc     1740



aggacataag gggagcaagg gagcccccgg tcctgctggt gctcgtgggg agagcggcct     1800



ggcaggagcc cccggacctg ctggaccacc aggcccccct gggccccctg ggcccccagg     1860



accaggactc cccgctggat ttgatgacat ggaaggctcc ggggggccct tctggtcaac     1920



agcccgaagc gctgatgggc cacagggacc tcccggcctg ccgggactta agggggatcc     1980



tggcgtgcct gggctgccgg gggcgaaggg agaagttgga gcagatggag tccccgggtt     2040



ccccggcctc cctggcagag agggcattgc tgggccccag gggccaaagg gagacagagg     2100



cagccgggga gaaaagggag atccagggaa ggacggagtc gggcagccgg gcctccctgg     2160



cccccccgga cccccgggac ctgtggtcta cgtgtcggag caggacggat ccgtcctgag     2220



cgtgccggga cctgagggcc ggccgggttt cgcaggcttt cccggacctg caggacccaa     2280



gggcaacctg ggctctaagg gcgaacgagg ctccccggga cccaagggtg agaagggtga     2340



accgggcagc atcttcagcc ccgacggcgg tgccctgggc cctgcccaga aaggagccaa     2400



gggagagccg ggcttccgag gacccccggg tccatacgga cggccggggt acaagggaga     2460



gattggcttt cctggacggc cgggtcgccc cgggatgaac ggattgaaag gagagaaagg     2520



ggagccggga gatgccagcc ttggatttgg catgagggga atgcccggcc ccccaggacc     2580



tccagggccc ccaggccctc cagggactcc tgtttacgac agcaatgtgt ttgctgagtc     2640



cagccgcccc gggcctccag gattgccagg gaatcagggc cctccaggac ccaagggcgc     2700



caaaggagaa gtgggccccc ccggaccacc agggcagttt ccgtttgact ttcttcagtt     2760



ggaggctgaa atgaaggggg agaagggaga ccgaggtgat gcaggacaga aaggcgaaag     2820



gggggagccc gggggcggcg gtttcttcgg ctccagcctg cccggccccc ccggcccccc     2880



aggcccacgt ggctaccctg ggattccagg tcccaaggga gagagcatcc ggggccagcc     2940



cggcccacct ggacctcagg gaccccccgg catcggctac gaggggcgcc agggccctcc     3000



cggcccccca ggccccccag ggcccccttc atttcctggc cctcacaggc agactatcag     3060



cgttcccggc cctccgggcc cccctgggcc ccctgggccc cctggaacca tgggcgcctc     3120



ctcaggggtg aggctctggg ctacacgcca ggccatgctg ggccaggtgc acgaggttcc     3180



cgagggctgg ctcatcttcg tggccgagca ggaggagctc tacgtccgcg tgcagaacgg     3240



gttccggaag gtccagctgg aggcccggac accactccca cgagggacgg acaatgaagt     3300



ggccgccttg cagccccccg tggtgcagct gcacgacagc aacccctacc cgcggcggga     3360



gcacccccac cccaccgcgc ggccctggcg ggcagatgac atcctggcca gcccccctcg     3420



cctgcccgag ccccagccct accccggagc cccgcaccac agctcctacg tgcacctgcg     3480



gccggcgcga cccacaagcc cacccgccca cagccaccgc gacttccagc cggtgctcca     3540



cctggttgcg ctcaacagcc ccctgtcagg cggcatgcgg ggcatccgcg gggccgactt     3600



ccagtgcttc cagcaggcgc gggccgtggg gctggcgggc accttccgcg ccttcctgtc     3660



ctcgcgcctg caggacctgt acagcatcgt gcgccgtgcc gaccgcgcag ccgtgcccat     3720



cgtcaacctc aaggacgagc tgctgtttcc cagctgggag gctctgttct caggctctga     3780



gggtccgctg aagcccgggg cacgcatctt ctcctttgac ggcaaggacg tcctgaggca     3840



ccccacctgg ccccagaaga gcgtgtggca tggctcggac cccaacgggc gcaggctgac     3900



cgagagctac tgtgagacgt ggcggacgga ggctccctcg gccacgggcc aggcctcctc     3960



gctgctgggg ggcaggctcc tggggcagag tgccgcgagc tgccatcacg cctacatcgt     4020



gctctgcatt gagaacagct tcatgactgc ctccaagtag ccaccgcctg gatgcggatg     4080



gccggagagg accggcggct cggaggaagc ccccaccgtg ggcagggagc ggccggccag     4140



cccctggccc caggacctgg ctgccatact ttcctgtata gttcacgttt catgtaatcc     4200



tcaagaaata aaaggaagcc aaagagtgta tttttttaaa agtttaaaac agaagcctga     4260



tgctgacatt cacctgcccc aactctcccc tgacctgtga gcccagctgg gtcaggcagg     4320



gtgcagtatc atgccctgtg caacctcttg gcctgatcag accacggctc gatttctcca     4380



ggatttcctg ctttgggaag ccgtgctcgc cccagcaggt gctgacttca tctcccacct     4440



agcagcaccg ttctgtgcac aaaacccaga cctgttagca gacaggcccc gtgaggcaat     4500



gggagctgag gccacactca gcacaaggcc atctgggctc ctccagggtg tgtgctcgcc     4560



ctgcggtaga tgggagggag gctcaggtcc ctggggctag ggggagcccc ttctgctcag     4620



ctctgggcca ttctccacag caaccccagg ctgaagcagg ttcccaagct cagaggcgca     4680



ctgtgacccc cagctccggc ctgtcctcca acaccaagca cagcagcctg gggctggcct     4740



cccaaatgag ccatgagatg atacatccaa agcagacagc tccaccctgg ccgagtccaa     4800



gctgggagat tcaagggacc catgagttgg ggtctggcag cctcccatcc agggccccca     4860



tctcatgccc ctggctggga cgtggctcag ccagcacttg tccagctgag cgccaggatg     4920



gaacacggcc acatcaaaga ggctgaggct ggcacaggac atgcggtagc cagcacacag     4980



ggcagtgagg gagggctgtc atctgtgcac tgcccatgga caggctggct ccagatgcag     5040



ggcagtcatt ggctgtctcc taggaaaccc atatccttac cctccttggg actgaagggg     5100



aaccccgggg tgcccacagg ccgccctgcg ggtgaacaaa gcagccacga ggtgcaacaa     5160



ggtcctctgt cagtcacagc cacccctgag atccggcaac atcaacccga gtcattcgtt     5220



ctgtggaggg acaagtggac tcagggcagc gccaggctga ccacagcaca gccaacacgc     5280



acctgcctca ggactgcgac gaaaccggtg gggctggttc tgtaattgtg tgtgatgtga     5340



agccaattca gacaggcaaa taaaagtgac cttttacact gaaaaaaaaa aaaaaaaa       5398





<210>  88

<211>  1336

<212>  PRT

<213>  Homo sapiens



<400>  88



Met Ala Pro Arg Cys Pro Trp Pro Trp Pro Arg Arg Arg Arg Leu Leu 

1               5                   10                  15      





Asp Val Leu Ala Pro Leu Val Leu Leu Leu Gly Val Arg Ala Ala Ser 

            20                  25                  30          





Ala Glu Pro Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu 

        35                  40                  45              





Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val 

    50                  55                  60                  





Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala 

65                  70                  75                  80  





Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe 

                85                  90                  95      





His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr 

            100                 105                 110         





Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val 

        115                 120                 125             





Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala 

    130                 135                 140                 





Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly 

145                 150                 155                 160 





Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu 

                165                 170                 175     





Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser 

            180                 185                 190         





Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala 

        195                 200                 205             





Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys 

    210                 215                 220                 





Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu 

225                 230                 235                 240 





Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly Ser Gly Leu Gly 

                245                 250                 255     





Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro 

            260                 265                 270         





Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly 

        275                 280                 285             





Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr 

    290                 295                 300                 





Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser 

305                 310                 315                 320 





Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly 

                325                 330                 335     





Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly 

            340                 345                 350         





Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu 

        355                 360                 365             





Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr 

    370                 375                 380                 





Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr 

385                 390                 395                 400 





Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro 

                405                 410                 415     





Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 

            420                 425                 430         





Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro 

        435                 440                 445             





Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp 

    450                 455                 460                 





Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu 

465                 470                 475                 480 





Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro 

                485                 490                 495     





Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser 

            500                 505                 510         





Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu 

        515                 520                 525             





Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 

    530                 535                 540                 





Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu 

545                 550                 555                 560 





Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala 

                565                 570                 575     





Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro Gly Pro Ala Gly 

            580                 585                 590         





Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Leu Pro 

        595                 600                 605             





Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro Phe Trp Ser Thr 

    610                 615                 620                 





Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly Leu Pro Gly Leu 

625                 630                 635                 640 





Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala Lys Gly Glu Val 

                645                 650                 655     





Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro Gly Arg Glu Gly 

            660                 665                 670         





Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly Ser Arg Gly Glu 

        675                 680                 685             





Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly Leu Pro Gly 

    690                 695                 700                 





Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser Glu Gln Asp Gly 

705                 710                 715                 720 





Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro Gly Phe Ala Gly 

                725                 730                 735     





Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly Ser Lys Gly Glu 

            740                 745                 750         





Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu Pro Gly Ser Ile 

        755                 760                 765             





Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln Lys Gly Ala Lys 

    770                 775                 780                 





Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly 

785                 790                 795                 800 





Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg Pro Gly Met 

                805                 810                 815     





Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala Ser Leu Gly 

            820                 825                 830         





Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 

        835                 840                 845             





Gly Pro Pro Gly Thr Pro Val Tyr Asp Ser Asn Val Phe Ala Glu Ser 

    850                 855                 860                 





Ser Arg Pro Gly Pro Pro Gly Leu Pro Gly Asn Gln Gly Pro Pro Gly 

865                 870                 875                 880 





Pro Lys Gly Ala Lys Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Gln 

                885                 890                 895     





Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met Lys Gly Glu Lys 

            900                 905                 910         





Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg Gly Glu Pro Gly 

        915                 920                 925             





Gly Gly Gly Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro 

    930                 935                 940                 





Gly Pro Arg Gly Tyr Pro Gly Ile Pro Gly Pro Lys Gly Glu Ser Ile 

945                 950                 955                 960 





Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Gly 

                965                 970                 975     





Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 

            980                 985                 990         





Pro Ser Phe Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 

        995                 1000                 1005             





Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 

    1010                 1015                 1020             





Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 

    1025                 1030                 1035             





Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 

    1040                 1045                 1050             





Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 

    1055                 1060                 1065             





Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 

    1070                 1075                 1080             





Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 

    1085                 1090                 1095             





Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 

    1100                 1105                 1110             





Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 

    1115                 1120                 1125             





Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 

    1130                 1135                 1140             





Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 

    1145                 1150                 1155             





Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 

    1160                 1165                 1170             





Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 

    1175                 1180                 1185             





Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 

    1190                 1195                 1200             





Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 

    1205                 1210                 1215             





Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 

    1220                 1225                 1230             





Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 

    1235                 1240                 1245             





Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 

    1250                 1255                 1260             





His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 

    1265                 1270                 1275             





Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 

    1280                 1285                 1290             





Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 

    1295                 1300                 1305             





Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 

    1310                 1315                 1320             





Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 

    1325                 1330                 1335     





<210>  89

<211>  5910

<212>  DNA

<213>  Homo sapiens



<400>  89

agctccagcc gcactgcccc gatggctccc tacccctgtg gctgccacat cctgctgctg       60



ctcttctgct gcctggcggc tgcccgggcc aacctgctga acctgaactg gctttggttc      120



aataatgagg acaccagcca tgcagctacc acgatccctg agccccaggg gcccctgcct      180



gtgcagccca cagcagatac caccacacac gtgacccccc ggaatggttc cacagagcca      240



gcgacagccc ctggcagccc tgagccaccc tcagagctgc tggaagatgg ccaggacacc      300



cccacttctg ccgagagccc ggacgcgcca gaggagaaca ttgccggtgt cggagccgag      360



atcctgaacg tggccaaagg catccggagc ttcgtccagc tgtggaatga cactgtcccc      420



actgagagct tggccagggc ggaaaccctg gtcctggaga ctcctgtggg cccccttgcc      480



ctcgctgggc cttccagcac cccccaggag aatgggacca ctctctggcc cagccgtggc      540



attcctagct ctccgggcgc ccacacaacc gaggctggca ccttgcctgc acccacccca      600



tcgcctccct ccctgggcag gccctgggca ccactcacgg ggccctcagt gccaccacca      660



tcttcagagc gcatcagcga ggaggtgggg ctgctgcagc tccttgggga ccccccgccc      720



cagcaggtca cccagacgga tgaccccgac gtcgggctgg cctacgtctt tgggccagat      780



gccaacagtg gccaagtggc ccggtaccac ttccccagcc tcttcttccg tgacttctca      840



ctgctgttcc acatccggcc agccacagag ggcccagggg tgctgttcgc catcacggac      900



tcggcgcagg ccatggtctt gctgggcgtg aagctctctg gggtgcagga cgggcaccag      960



gacatctccc tgctctacac agaaccaggt gcaggccaga cccacacagc cgccagcttc     1020



cggctccccg ccttcgtcgg ccagtggaca cacttagccc tcagtgtggc aggtggcttt     1080



gtggccctct acgtggactg tgaggagttc cagagaatgc cgcttgctcg gtcctcacgg     1140



ggcctggagc tggagcctgg cgccgggctc ttcgtggctc aggcgggggg agcggaccct     1200



gacaagttcc agggggtgat cgctgagctg aaggtgcgca gggaccccca ggtgagcccc     1260



atgcactgcc tggacgagga aggcgatgac tcagatgggg catccggaga ctctggcagc     1320



gggctcgggg acgcccggga gcttctcagg gaggagacgg gcgcggccct aaaacccagg     1380



ctccccgcgc caccccccgt caccacgcca cccttggctg gaggcagcag cacggaagat     1440



tccagaagtg aagaagtcga ggagcagacc acggtggctt cgttaggagc tcagacactt     1500



cctggctcag attctgtctc cacgtgggac gggagtgtcc ggacccctgg gggccgcgtg     1560



aaagagggcg gcctgaaggg gcagaaaggg gagccaggtg ttccgggccc acctggccgg     1620



gcaggccccc caggatcccc atgcctacct ggtcccccgg gtctcccgtg cccagtgagt     1680



cccctgggtc ctgcaggccc agcgttgcaa actgtccccg gaccacaagg acccccaggg     1740



cctccgggga gggacggcac ccctggaagg gacggcgagc cgggcgaccc cggtgaagac     1800



ggaaagccgg gcgacaccgg gccacaaggc ttccccggga ctccagggga cgtaggtccc     1860



aagggcgaca agggagaccc tggggttgga gagagagggc ccccaggacc ccaagggcct     1920



ccagggcccc caggaccctc cttcagacac gacaagctga ccttcattga catggaggga     1980



tctggcttcg ggggcgatct ggaggccctg cggggtcctc gaggcttccc tggacctccc     2040



ggaccccccg gtgtcccagg cctgcccggc gagccaggcc gctttggggt gaacagctcc     2100



gacgtcccag gacccgccgg ccttcctggt gtgcctgggc gcgagggtcc ccccgggttt     2160



cctggcctcc cgggaccccc aggccctccg ggaagagagg ggcccccagg aaggactggg     2220



cagaaaggca gcctgggtga agcaggcgcc ccaggacata aggggagcaa gggagccccc     2280



ggtcctgctg gtgctcgtgg ggagagcggc ctggcaggag cccccggacc tgctggacca     2340



ccaggccccc ctgggccccc tgggccccca ggaccaggac tccccgctgg atttgatgac     2400



atggaaggct ccggggggcc cttctggtca acagcccgaa gcgctgatgg gccacaggga     2460



cctcccggcc tgccgggact taagggggat cctggcgtgc ctgggctgcc gggggcgaag     2520



ggagaagttg gagcagatgg agtccccggg ttccccggcc tccctggcag agagggcatt     2580



gctgggcccc aggggccaaa gggagacaga ggcagccggg gagaaaaggg agatccaggg     2640



aaggacggag tcgggcagcc gggcctccct ggcccccccg gacccccggg acctgtggtc     2700



tacgtgtcgg agcaggacgg atccgtcctg agcgtgccgg gacctgaggg ccggccgggt     2760



ttcgcaggct ttcccggacc tgcaggaccc aagggcaacc tgggctctaa gggcgaacga     2820



ggctccccgg gacccaaggg tgagaagggt gaaccgggca gcatcttcag ccccgacggc     2880



ggtgccctgg gccctgccca gaaaggagcc aagggagagc cgggcttccg aggacccccg     2940



ggtccatacg gacggccggg gtacaaggga gagattggct ttcctggacg gccgggtcgc     3000



cccgggatga acggattgaa aggagagaaa ggggagccgg gagatgccag ccttggattt     3060



ggcatgaggg gaatgcccgg ccccccagga cctccagggc ccccaggccc tccagggact     3120



cctgtttacg acagcaatgt gtttgctgag tccagccgcc ccgggcctcc aggattgcca     3180



gggaatcagg gccctccagg acccaagggc gccaaaggag aagtgggccc ccccggacca     3240



ccagggcagt ttccgtttga ctttcttcag ttggaggctg aaatgaaggg ggagaaggga     3300



gaccgaggtg atgcaggaca gaaaggcgaa aggggggagc ccgggggcgg cggtttcttc     3360



ggctccagcc tgcccggccc ccccggcccc ccaggcccac gtggctaccc tgggattcca     3420



ggtcccaagg gagagagcat ccggggccag cccggcccac ctggacctca gggacccccc     3480



ggcatcggct acgaggggcg ccagggccct cccggccccc caggcccccc agggccccct     3540



tcatttcctg gccctcacag gcagactatc agcgttcccg gccctccggg cccccctggg     3600



ccccctgggc cccctggaac catgggcgcc tcctcagggg tgaggctctg ggctacacgc     3660



caggccatgc tgggccaggt gcacgaggtt cccgagggct ggctcatctt cgtggccgag     3720



caggaggagc tctacgtccg cgtgcagaac gggttccgga aggtccagct ggaggcccgg     3780



acaccactcc cacgagggac ggacaatgaa gtggccgcct tgcagccccc cgtggtgcag     3840



ctgcacgaca gcaaccccta cccgcggcgg gagcaccccc accccaccgc gcggccctgg     3900



cgggcagatg acatcctggc cagcccccct cgcctgcccg agccccagcc ctaccccgga     3960



gccccgcacc acagctccta cgtgcacctg cggccggcgc gacccacaag cccacccgcc     4020



cacagccacc gcgacttcca gccggtgctc cacctggttg cgctcaacag ccccctgtca     4080



ggcggcatgc ggggcatccg cggggccgac ttccagtgct tccagcaggc gcgggccgtg     4140



gggctggcgg gcaccttccg cgccttcctg tcctcgcgcc tgcaggacct gtacagcatc     4200



gtgcgccgtg ccgaccgcgc agccgtgccc atcgtcaacc tcaaggacga gctgctgttt     4260



cccagctggg aggctctgtt ctcaggctct gagggtccgc tgaagcccgg ggcacgcatc     4320



ttctcctttg acggcaagga cgtcctgagg caccccacct ggccccagaa gagcgtgtgg     4380



catggctcgg accccaacgg gcgcaggctg accgagagct actgtgagac gtggcggacg     4440



gaggctccct cggccacggg ccaggcctcc tcgctgctgg ggggcaggct cctggggcag     4500



agtgccgcga gctgccatca cgcctacatc gtgctctgca ttgagaacag cttcatgact     4560



gcctccaagt agccaccgcc tggatgcgga tggccggaga ggaccggcgg ctcggaggaa     4620



gcccccaccg tgggcaggga gcggccggcc agcccctggc cccaggacct ggctgccata     4680



ctttcctgta tagttcacgt ttcatgtaat cctcaagaaa taaaaggaag ccaaagagtg     4740



tattttttta aaagtttaaa acagaagcct gatgctgaca ttcacctgcc ccaactctcc     4800



cctgacctgt gagcccagct gggtcaggca gggtgcagta tcatgccctg tgcaacctct     4860



tggcctgatc agaccacggc tcgatttctc caggatttcc tgctttggga agccgtgctc     4920



gccccagcag gtgctgactt catctcccac ctagcagcac cgttctgtgc acaaaaccca     4980



gacctgttag cagacaggcc ccgtgaggca atgggagctg aggccacact cagcacaagg     5040



ccatctgggc tcctccaggg tgtgtgctcg ccctgcggta gatgggaggg aggctcaggt     5100



ccctggggct agggggagcc ccttctgctc agctctgggc cattctccac agcaacccca     5160



ggctgaagca ggttcccaag ctcagaggcg cactgtgacc cccagctccg gcctgtcctc     5220



caacaccaag cacagcagcc tggggctggc ctcccaaatg agccatgaga tgatacatcc     5280



aaagcagaca gctccaccct ggccgagtcc aagctgggag attcaaggga cccatgagtt     5340



ggggtctggc agcctcccat ccagggcccc catctcatgc ccctggctgg gacgtggctc     5400



agccagcact tgtccagctg agcgccagga tggaacacgg ccacatcaaa gaggctgagg     5460



ctggcacagg acatgcggta gccagcacac agggcagtga gggagggctg tcatctgtgc     5520



actgcccatg gacaggctgg ctccagatgc agggcagtca ttggctgtct cctaggaaac     5580



ccatatcctt accctccttg ggactgaagg ggaaccccgg ggtgcccaca ggccgccctg     5640



cgggtgaaca aagcagccac gaggtgcaac aaggtcctct gtcagtcaca gccacccctg     5700



agatccggca acatcaaccc gagtcattcg ttctgtggag ggacaagtgg actcagggca     5760



gcgccaggct gaccacagca cagccaacac gcacctgcct caggactgcg acgaaaccgg     5820



tggggctggt tctgtaattg tgtgtgatgt gaagccaatt cagacaggca aataaaagtg     5880



accttttaca ctgaaaaaaa aaaaaaaaaa                                      5910





<210>  90

<211>  1516

<212>  PRT

<213>  Homo sapiens



<400>  90



Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 

1               5                   10                  15      





Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 

            20                  25                  30          





Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 

        35                  40                  45              





Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 

    50                  55                  60                  





Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 

65                  70                  75                  80  





Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 

                85                  90                  95      





Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 

            100                 105                 110         





Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 

        115                 120                 125             





Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 

    130                 135                 140                 





Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 

145                 150                 155                 160 





Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 

                165                 170                 175     





Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 

            180                 185                 190         





Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 

        195                 200                 205             





Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 

    210                 215                 220                 





Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 

225                 230                 235                 240 





Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 

                245                 250                 255     





Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 

            260                 265                 270         





Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 

        275                 280                 285             





Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 

    290                 295                 300                 





Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 

305                 310                 315                 320 





Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 

                325                 330                 335     





Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 

            340                 345                 350         





Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 

        355                 360                 365             





Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 

    370                 375                 380                 





Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 

385                 390                 395                 400 





Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 

                405                 410                 415     





Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly 

            420                 425                 430         





Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 

        435                 440                 445             





Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 

    450                 455                 460                 





Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 

465                 470                 475                 480 





Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 

                485                 490                 495     





Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 

            500                 505                 510         





Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 

        515                 520                 525             





Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 

    530                 535                 540                 





Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 

545                 550                 555                 560 





Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 

                565                 570                 575     





Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 

            580                 585                 590         





Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 

        595                 600                 605             





Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 

    610                 615                 620                 





Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 

625                 630                 635                 640 





Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 

                645                 650                 655     





Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 

            660                 665                 670         





Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 

        675                 680                 685             





Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 

    690                 695                 700                 





Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 

705                 710                 715                 720 





Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 

                725                 730                 735     





Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 

            740                 745                 750         





Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 

        755                 760                 765             





Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 

    770                 775                 780                 





Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 

785                 790                 795                 800 





Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 

                805                 810                 815     





Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 

            820                 825                 830         





Lys Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro 

        835                 840                 845             





Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 

    850                 855                 860                 





Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 

865                 870                 875                 880 





Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 

                885                 890                 895     





Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 

            900                 905                 910         





Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 

        915                 920                 925             





Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 

    930                 935                 940                 





Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 

945                 950                 955                 960 





Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 

                965                 970                 975     





Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 

            980                 985                 990         





Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 

        995                 1000                 1005             





Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 

    1010                 1015                 1020             





Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 

    1025                 1030                 1035             





Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 

    1040                 1045                 1050             





Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 

    1055                 1060                 1065             





Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 

    1070                 1075                 1080             





Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 

    1085                 1090                 1095             





Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 

    1100                 1105                 1110             





Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly 

    1115                 1120                 1125             





Tyr Pro  Gly Ile Pro Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln 

    1130                 1135                 1140             





Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu 

    1145                 1150                 1155             





Gly Arg  Gln Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 

    1160                 1165                 1170             





Ser Phe  Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 

    1175                 1180                 1185             





Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 

    1190                 1195                 1200             





Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 

    1205                 1210                 1215             





Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 

    1220                 1225                 1230             





Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 

    1235                 1240                 1245             





Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 

    1250                 1255                 1260             





Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 

    1265                 1270                 1275             





Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 

    1280                 1285                 1290             





Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 

    1295                 1300                 1305             





Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 

    1310                 1315                 1320             





Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 

    1325                 1330                 1335             





Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 

    1340                 1345                 1350             





Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 

    1355                 1360                 1365             





Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 

    1370                 1375                 1380             





Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 

    1385                 1390                 1395             





Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 

    1400                 1405                 1410             





Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 

    1415                 1420                 1425             





Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 

    1430                 1435                 1440             





His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 

    1445                 1450                 1455             





Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 

    1460                 1465                 1470             





Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 

    1475                 1480                 1485             





Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 

    1490                 1495                 1500             





Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 

    1505                 1510                 1515     





<210>  91

<211>  874

<212>  DNA

<213>  Homo sapiens



<400>  91

gaagtgaact tagaggttgt ggggccgagg ggtcgtctta tagctaccag cccacaggca       60



tttagtctac gttggaggta aacaaatacg ggtcctgctt aggagaaaag aaaaacgtct      120



tacagccagt gtctaaactc caaacaacgg aatgtatcaa tgagaccttg tatatggata      180



cacgtgcatt taaaaccgcc ctgccggctt gtagagcttt tgccgttctc cagcgcttta      240



caggggttat cgcacttaag cctcggaaca actttaccag tgattctacc agaaaggaat      300



gaagaacaga accttcagga attgagtcac aatgcagaca aatatcaaat gggagattgt      360



tgcaaggaag agattgatga tagtattttc tactagccat tgggaagata aaaggagaca      420



gaagattgaa gcctttgcca gccattcttt ccctttttgc ttccaaactc ctcaactggg      480



aaccttcata tgtgcagtat ttatattgga tcatactggt gattataaaa gttcctagga      540



ggctagaaga gccaaccaac agagaaggga aagcagtctg ttctgaacat agggacataa      600



gttcattcat gccaagtatc tttccagcat gtttctccca tttagaatat ctagcatgta      660



aggcctttca atattaatat aagcccaata tcagctcttt ctctttgtat ttcatctctt      720



tctactctcc tatttgtatt ttgtgttcct atcaaagtgt cgtatctggg agatgacctg      780



ccttatcctg ttctataaca gttttgtttg ctgctgtgtc tttagaacag tgcctggcac      840



acagtaagca ctcaataaat ctttgatgaa tgaa                                  874





<210>  92

<211>  2768

<212>  DNA

<213>  Homo sapiens



<400>  92

ggagctttgc tgaaactgca caaaaaatcg agccgggggg ttccctggtc cccggcgatg       60



gggcggggag cgctgcgccg ggggaggggg cgggcgcggc ggcgcgggcc ccgccgaggg      120



gggacacctg gctgaggcac agctgccgcc gtgcctttcc gcgcgagccc agagctccga      180



tccctgcgcg ggctcgagag ctcgccccga acgggggtct tcctcctccg ccgttgacag      240



gttttgacct gtagcagaga accaattctg gagaacagcc tcacttcttt gattgaatac      300



ttacataatg cattggaaca tgacatgaga ttaaggttta ataatgatag aatgaagacc      360



acaataaaag agacctctac ttagctcagc aattcttacc tttcttacct atttgatgaa      420



gatgtctttt gaaaggtgta ctgcaaggaa caaaatgttt gtaaattctc cttttaccaa      480



ggtggataat tactgtacct tcctcatgga aaaagtttta tttaaagtgt tatttctcat      540



tgaatactat caaaaaggaa aaaaaaatga cctaaacttt tgagatagat ttggctctag      600



gcctactcta ggtgcggtac ttcactatag tttataaaag atggtccctg tcagcaaaga      660



actgtaacct gtatgagaat attatactaa catacaagaa acaagtagag aataatggaa      720



tgtaaactct ggcttgctaa cttaagtgtg gtagaagctt gaaggaaatg tggacttaaa      780



cttatcagag aagacttata agaggatatg aaaggtgtaa attttgatac caccattgcc      840



gccttcccct caaaaaaggt gagaactgac taaactactg gtacttagac catgtggaga      900



aggaactgaa aatggaaaca gaaacacgtc tgtacagagc agagtgtcag ataatagctc      960



attttagtag agggcaataa atgccacatg agatgatcac ctcagcagaa aactgggatg     1020



tggagacgct ggtagcgggg ccaggaaggc tccggacgga gcaggttttc tggaccacag     1080



acacactgcc ccggcgccct ccgcaggccg ctcctcccca ggcccatgac agtgccccgc     1140



tggtttctgc cgcgctgccg gactggagct cagacggcct tcgccagccc ccccaaccca     1200



cgcagatccc tgctgacctg ggcaactccc caccctcgct gaaggttcga ggaccacccc     1260



gctttcccga gaggagccgg gcggcgggta cttatctccg acctccggct agtgggaaag     1320



gccgcgcgac cgcccgtcct ccaactacag ggaccgcacg aacagcgact gggaaactgc     1380



cactagaaaa agatgactgt ccaactaaaa cctgcataca cagctacatc cttccctgga     1440



agagcacagt ggaactagat cctagtacag atagcacagg gattgtcaac attcttgtca     1500



cactgaaatt tccttctact gatctccaaa cttctaaaaa tttgctgttg agaccagctg     1560



aaatgtttga aagaagcaac taaagaaaga aactttgaaa gaagcttcca aaagaagcaa     1620



ccaagtctac aaaggcacag tttgactcaa atggatccaa ctgattagca aatggaaaat     1680



aacatggagg aatatatttt gcatgacaag catagcagct ccaagtcatc cctaatgaag     1740



ccaaaaattt aagtgcaacc cagagaatgg atggttcaga atcttttttt tttttgagat     1800



ggagtctcgc tctgtcacct aggctggagt gcggtggcat gatctcggct cactgcaagc     1860



tccgcctcct gggttcacgc cattctcctg cctcagcctt ccgggtagct gggactacag     1920



gtgcctgcca ccacgcccgg ctaatttttt gtatttttag tagagacggg gtttcaccgt     1980



gttagctagg atggtctcaa tctcctgacc tcgtgatctg cccgcctcag cctcccaaag     2040



tgctggaatt acaggcgtga gccaccgcgc ccggcccaga atctttttta aattttttat     2100



tattattatt ttttctgaga tggagtccgg ctctgtggcc aggctggagt gcagtggcac     2160



aatctcagct cactgcaacc tctgactccc aggtacaagt gattctcctg cctcagcctc     2220



ctgagtagct gggataacag gcacgtgcca ccacgcccag ctaatttttg tatttttagt     2280



agagacgggg tttcaccatg ttggccagga tggtctcgat ctgcctacct tggcctccca     2340



atgtactggg attacaggcg tgagccaccg tacccggccc agaatctttg ccttttgttt     2400



gcatagttta atcttctaaa ccagttgctt tcccagaaaa ggtgacttaa agtcatagcc     2460



tttgtgttca tcaccatact ctccatagtt ttacaaatta ttcagtttat ttttaaaagg     2520



ggtaattttt aaaattttta tttttaattc cgaagcattc cttttaatac attctcttga     2580



gggaaaaaaa aaatcacaca tagtgattgt gtgtggtagt gattatgtgt ggcctaagtg     2640



gcaattgatc aataccccaa tctcaagcct gtacattgtt actggttgac tggttggttg     2700



cctggtgggc tttttgtcct tccagatgtt tttctacctt ctgccttttc caataaagct     2760



tccattat                                                              2768





<210>  93

<211>  4052

<212>  DNA

<213>  Homo sapiens



<400>  93

aagtaagtgc gatggaacct tcaggttcca accgccgcca gggccgctcc gcccagtgga       60



gcctgtccgg cccccttgct gcccgctagc tcccgccggc tggcgcaagc tgtcggcgcc      120



ggggcactgc gggcggggtc ggagcctggc cttcctgacg ttgcagctgc cgtccccgca      180



cgttccggcc agggcctccc tcttagggcc gggcggtgcc cgtggctcag gctgcagagt      240



agaaagcaca aaaaccagcc tgattgtatc tggaaaaaac cattatgtta cagttgatag      300



gctcacccca aaatatgctt ttggggactg atttagcacc tgcatattct gcgtgaatct      360



ctttaattgg ttgcagttga gctaatggtg gagccaaaat gctattgccc tgtcttcatc      420



aacatttaat caagtgttgc ggagatagga acatgggaga gaaacaatct gggtaacatg      480



aaagtgatgc tggttgctaa gggaaggcaa cttgattctg tgggaagggc tgtagctgat      540



ccatccgttg tctagatttg agtatgagca cagtggaaga ggattctgac acagtaacag      600



tagaaactgt gaactctgtg actttgactc aggacacaga agggaatctc attcttcact      660



gccctcagaa tgaagcggat gaaatagact cagaagatag tattgaacct ccacataaaa      720



ggctttgttt gtcctctgag gatgatcaga gtattgatga ttctactcct tgcatatcag      780



ttgttgcact tccactttca gaaaatgatc agagctttga agtgaccatg actgcaacca      840



cagaagtagc agatgatgag gttactgagg ggactgtgac acagatacag attttgcaga      900



atgagcaact agatgaaata tctcccttgg gtaacgagga agtttcagca gttagccaag      960



catggtttac aactaaagaa gataaggatt ctctgactaa taaaggacat aaatggaagc     1020



aggggatgtg gtccaaggaa gaaattgata ttttgatgaa caatattgaa cgctatctta     1080



aggcacgcgg aataaaagat gctacagaaa tcatctttga gatgtcaaaa gacgaaagaa     1140



aagatttcta caggactata gcatggggtc tgaaccggcc tttgtttgca gtttatagaa     1200



gagtgcttcg catgtatgat gacagaaacc atgtgggaaa atatacacct gaagaaattg     1260



agaagctcaa ggagctccgg ataaagcatg gcaatgactg ggcaacaata ggggcggcgc     1320



taggaagaag tgcatcttct gtcaaagatc ggtgccgact gatgaaggat acttgcaaca     1380



cagggaagtg gacagaagaa gaagaaaaga gacttgcaga agtggttcat gagttgacaa     1440



gcactgagcc aggtgacata gtcacacagg gtgtgtcttg ggcagctgtg gctgaacgag     1500



tcggtacccg ctcagaaaag caatgtcgtt ctaaatggct caactacctg aattggaaac     1560



agagtggggg tactgaatgg accaaggaag atgaaatcaa tctcatcctc aggatagcag     1620



aacttgatgt agctgatgaa aatgacatta actgggatct gttagctgag ggatggagta     1680



gtgtccgttc accacaatgg ctacgaagta aatggtggac catcaaaagg caaattgcaa     1740



accataagga tgtttcgttc cctgtcttaa taaaaggtct taaacagtta catgagaacc     1800



aaaaaaacaa cccaacgctt ttggagaata aatcaggatc tggagttcca aacagtaata     1860



ccaattccag tgtgcagcat gttcagataa gagttgcccg cttggaagat aatacagcca     1920



tctcttctag ccccatggca gcattgcaga ttccagtcca gatcacccat gtttcttcag     1980



cagactctcc tgctaccgtt gactcagaaa caataacact aaacagtgga acactacaga     2040



catttgagat tcttccctct ttccatctac agcccactgg cactccaggc acctacctac     2100



ttcaaacaag ctcaagccaa ggccttcccc taactctgac tgctagtccc acagtaaccc     2160



tgacagctgc tgctcctgct tctcctgaac agattattgt tcatgcttta tccccagaac     2220



atttgttgaa cacaagtgat aatgttacag tgcagtgtca cacaccaaga gtcatcattc     2280



agactgttgc cacagaggac atcacttctt ccatatccca agcagaactg acagtcgata     2340



gtgatattca gtcatctgat tttcctgagc ctccagacgc cctagaagca gacactttcc     2400



cagatgaaat tcatcaccct aagatgactg tggagccatc atttaatgat gctcatgtat     2460



ccaaattcag tgaccaaaat agcacagaac tgatgaatag tgttatggtc agaacagaag     2520



aagaaatctc tgacaccgac cttaaacaag aggaatcacc ctctgattta gccagtgctt     2580



atgttactga gggtttagag tctcccacta tagaagaaca agttgatcaa acaattgatg     2640



atgaaacaat acttatcgtt ccttcaccac atggctttat ccaggcatct gatgttatag     2700



atactgaatc tgtcttgcct ttgacaacac taacagatcc catactccaa catcatcagg     2760



aagaatcaaa tatcattgga tcatccttgg gcagtcctgt ttcagaagat tcaaaggatg     2820



tcgaagattt ggtaaactgt cattagaata attcttagaa ataggcagtt caagcaaaga     2880



aggcacactg ttaattacaa cctcttcaaa gaaataggag caacccccaa gaggcttaat     2940



ttaccaattt aaatagccac agtccttaag ccacacacat tgttgctgct atgacttttt     3000



acctccttta aacacatcat ctgaggttga gttttatgac agtatgtagt tgagtggagg     3060



ctgggagttt taagcataaa tccctgttta gtgttacatg ggaataagga atttcattca     3120



cttcagccac taagaaaagt ttagaatcac gaaagcttaa ctgctgtggt ttaaagtaca     3180



gtttctctaa agatcagaca tggcactgtc tcctctcaag cctggttgta gttcagatga     3240



gtcttttcaa catggtcttc aacatggtct agagcttacc agtgatcttc tgatcttcaa     3300



gaagactaag tttgagactt gaccagcata caagtataga gacctaggag gtggtcttgt     3360



ggtggtacat ttggttaacc cattgctggc agtgggagct gatttaggca gggtaaacag     3420



gaaagcatta aaagttaaaa ttcactacag gttttttgtt acttttaaag ggaatatgga     3480



taagcatagt aacaaaaccc accagaatct aagcagtttt caccccctca gaaaccactg     3540



tcattagttt acaaagttag cactttgaag taaaactaaa tgaggaagga agtaatgtta     3600



cctatccttg ataccatgac catttattag atgttttgct atataaatta ccgagagaat     3660



agtttgtcat ccacttagtg tgttagctgg tggggtacaa tataacctct catctcaggc     3720



tattttaaaa aaacaatatt tgcttctata acaaaaggaa acaaatctaa gaatcattcc     3780



tgtactacag aagggttaag gcaaaggtag ccttttgggc tttttaatga atatgacccc     3840



tatagaaaag tcaagaaaaa aaaacccttg tataaattat tttatttatt attgtaatta     3900



gatcttcaca aagttgtctt ttcactgtgt tttgtcaacg tgaaattaaa ttgtagttat     3960



aagcaaaagt tggttgccta gggaacaatt gtatattcag tttaacagaa ataaaagaat     4020



atttgtctta agatgcaaaa aaaaaaaaaa aa                                   4052





<210>  94

<211>  760

<212>  PRT

<213>  Homo sapiens



<400>  94



Met Ser Thr Val Glu Glu Asp Ser Asp Thr Val Thr Val Glu Thr Val 

1               5                   10                  15      





Asn Ser Val Thr Leu Thr Gln Asp Thr Glu Gly Asn Leu Ile Leu His 

            20                  25                  30          





Cys Pro Gln Asn Glu Ala Asp Glu Ile Asp Ser Glu Asp Ser Ile Glu 

        35                  40                  45              





Pro Pro His Lys Arg Leu Cys Leu Ser Ser Glu Asp Asp Gln Ser Ile 

    50                  55                  60                  





Asp Asp Ser Thr Pro Cys Ile Ser Val Val Ala Leu Pro Leu Ser Glu 

65                  70                  75                  80  





Asn Asp Gln Ser Phe Glu Val Thr Met Thr Ala Thr Thr Glu Val Ala 

                85                  90                  95      





Asp Asp Glu Val Thr Glu Gly Thr Val Thr Gln Ile Gln Ile Leu Gln 

            100                 105                 110         





Asn Glu Gln Leu Asp Glu Ile Ser Pro Leu Gly Asn Glu Glu Val Ser 

        115                 120                 125             





Ala Val Ser Gln Ala Trp Phe Thr Thr Lys Glu Asp Lys Asp Ser Leu 

    130                 135                 140                 





Thr Asn Lys Gly His Lys Trp Lys Gln Gly Met Trp Ser Lys Glu Glu 

145                 150                 155                 160 





Ile Asp Ile Leu Met Asn Asn Ile Glu Arg Tyr Leu Lys Ala Arg Gly 

                165                 170                 175     





Ile Lys Asp Ala Thr Glu Ile Ile Phe Glu Met Ser Lys Asp Glu Arg 

            180                 185                 190         





Lys Asp Phe Tyr Arg Thr Ile Ala Trp Gly Leu Asn Arg Pro Leu Phe 

        195                 200                 205             





Ala Val Tyr Arg Arg Val Leu Arg Met Tyr Asp Asp Arg Asn His Val 

    210                 215                 220                 





Gly Lys Tyr Thr Pro Glu Glu Ile Glu Lys Leu Lys Glu Leu Arg Ile 

225                 230                 235                 240 





Lys His Gly Asn Asp Trp Ala Thr Ile Gly Ala Ala Leu Gly Arg Ser 

                245                 250                 255     





Ala Ser Ser Val Lys Asp Arg Cys Arg Leu Met Lys Asp Thr Cys Asn 

            260                 265                 270         





Thr Gly Lys Trp Thr Glu Glu Glu Glu Lys Arg Leu Ala Glu Val Val 

        275                 280                 285             





His Glu Leu Thr Ser Thr Glu Pro Gly Asp Ile Val Thr Gln Gly Val 

    290                 295                 300                 





Ser Trp Ala Ala Val Ala Glu Arg Val Gly Thr Arg Ser Glu Lys Gln 

305                 310                 315                 320 





Cys Arg Ser Lys Trp Leu Asn Tyr Leu Asn Trp Lys Gln Ser Gly Gly 

                325                 330                 335     





Thr Glu Trp Thr Lys Glu Asp Glu Ile Asn Leu Ile Leu Arg Ile Ala 

            340                 345                 350         





Glu Leu Asp Val Ala Asp Glu Asn Asp Ile Asn Trp Asp Leu Leu Ala 

        355                 360                 365             





Glu Gly Trp Ser Ser Val Arg Ser Pro Gln Trp Leu Arg Ser Lys Trp 

    370                 375                 380                 





Trp Thr Ile Lys Arg Gln Ile Ala Asn His Lys Asp Val Ser Phe Pro 

385                 390                 395                 400 





Val Leu Ile Lys Gly Leu Lys Gln Leu His Glu Asn Gln Lys Asn Asn 

                405                 410                 415     





Pro Thr Leu Leu Glu Asn Lys Ser Gly Ser Gly Val Pro Asn Ser Asn 

            420                 425                 430         





Thr Asn Ser Ser Val Gln His Val Gln Ile Arg Val Ala Arg Leu Glu 

        435                 440                 445             





Asp Asn Thr Ala Ile Ser Ser Ser Pro Met Ala Ala Leu Gln Ile Pro 

    450                 455                 460                 





Val Gln Ile Thr His Val Ser Ser Ala Asp Ser Pro Ala Thr Val Asp 

465                 470                 475                 480 





Ser Glu Thr Ile Thr Leu Asn Ser Gly Thr Leu Gln Thr Phe Glu Ile 

                485                 490                 495     





Leu Pro Ser Phe His Leu Gln Pro Thr Gly Thr Pro Gly Thr Tyr Leu 

            500                 505                 510         





Leu Gln Thr Ser Ser Ser Gln Gly Leu Pro Leu Thr Leu Thr Ala Ser 

        515                 520                 525             





Pro Thr Val Thr Leu Thr Ala Ala Ala Pro Ala Ser Pro Glu Gln Ile 

    530                 535                 540                 





Ile Val His Ala Leu Ser Pro Glu His Leu Leu Asn Thr Ser Asp Asn 

545                 550                 555                 560 





Val Thr Val Gln Cys His Thr Pro Arg Val Ile Ile Gln Thr Val Ala 

                565                 570                 575     





Thr Glu Asp Ile Thr Ser Ser Ile Ser Gln Ala Glu Leu Thr Val Asp 

            580                 585                 590         





Ser Asp Ile Gln Ser Ser Asp Phe Pro Glu Pro Pro Asp Ala Leu Glu 

        595                 600                 605             





Ala Asp Thr Phe Pro Asp Glu Ile His His Pro Lys Met Thr Val Glu 

    610                 615                 620                 





Pro Ser Phe Asn Asp Ala His Val Ser Lys Phe Ser Asp Gln Asn Ser 

625                 630                 635                 640 





Thr Glu Leu Met Asn Ser Val Met Val Arg Thr Glu Glu Glu Ile Ser 

                645                 650                 655     





Asp Thr Asp Leu Lys Gln Glu Glu Ser Pro Ser Asp Leu Ala Ser Ala 

            660                 665                 670         





Tyr Val Thr Glu Gly Leu Glu Ser Pro Thr Ile Glu Glu Gln Val Asp 

        675                 680                 685             





Gln Thr Ile Asp Asp Glu Thr Ile Leu Ile Val Pro Ser Pro His Gly 

    690                 695                 700                 





Phe Ile Gln Ala Ser Asp Val Ile Asp Thr Glu Ser Val Leu Pro Leu 

705                 710                 715                 720 





Thr Thr Leu Thr Asp Pro Ile Leu Gln His His Gln Glu Glu Ser Asn 

                725                 730                 735     





Ile Ile Gly Ser Ser Leu Gly Ser Pro Val Ser Glu Asp Ser Lys Asp 

            740                 745                 750         





Val Glu Asp Leu Val Asn Cys His 

        755                 760 





<210>  95

<211>  1326

<212>  DNA

<213>  Homo sapiens



<400>  95

ccgcccctct gccccagtca ctgagccgcc gccgaggatt cagcagcctc ccccttgagc       60



cccctcgctt cccgacgttc cgttcccccc tgcccgcctt ctcccgccac cgccgccgcc      120



gccttccgca ggccgtttcc accgaggaaa aggaatcgta tcgtatgtcc gctatccaga      180



acctccactc tttcgacccc tttgctgatg caagtaaggg tgatgacctg cttcctgctg      240



gcactgagga ttatatccat ataagaattc aacagagaaa cggcaggaag acccttacta      300



ctgtccaagg gatcgctgat gattacgata aaaagaaact agtgaaggcg tttaagaaaa      360



agtttgcctg caatggtact gtaattgagc atccggaata tggagaagta attcagctac      420



agggtgacca acgcaagaac atatgccagt tcctcgtaga gattggactg gctaaggacg      480



atcagctgaa ggttcatggg ttttaagtgc ttgtggctca ctgaagctta agtgaggatt      540



tccttgcaat gagtagaatt tcccttctct cccttgtcac aggtttaaaa acctcacagc      600



ttgtataatg taaccatttg gggtccgctt ttaacttgga ctagtgtaac tccttcatgc      660



aataaactga aaagagccat gctgtctagt cttgaagtcc ctcatttaaa cagaggtcaa      720



gcaataggcg cctggcagtg tcaagcctga aaccaagcaa taccgtcatg tttcagccaa      780



gcccagagcc ctaagattac aaacaactat ggccggaacc tcctcagctc tccctctgca      840



gagttcccta ccctaagaga atgttaccac ctgaacagtc ctcggtgaat ctgagaggag      900



aggatggggt aaggcagaag caccagctgt actactagaa gggagctttt ggtggtagat      960



cccctggtgt ctccaacctg actaggtgga cagagctcaa agaggccctc ttaccgctag     1020



cgaggtgata ggacatctgg cttgccacaa aggtctgttc gaccagacat atcctagcta     1080



agggatgtcc aaacatcaga atgtgaggcc aaccttctat cagagttaaa cttttgacaa     1140



gggaacaaat ctcaaactga tccatcagtc atgtagctag ctgtagagct tgcaacttaa     1200



tagcagcagc tgcccaatgc catgtgaagt aacaaactgg tttttggttt ttttttcccc     1260



ttcagtttta atgttatgtg taatgtattt aaacccttat ttaaataaaa cttgttttca     1320



gaaata                                                                1326





<210>  96

<211>  113

<212>  PRT

<213>  Homo sapiens



<400>  96



Met Ser Ala Ile Gln Asn Leu His Ser Phe Asp Pro Phe Ala Asp Ala 

1               5                   10                  15      





Ser Lys Gly Asp Asp Leu Leu Pro Ala Gly Thr Glu Asp Tyr Ile His 

            20                  25                  30          





Ile Arg Ile Gln Gln Arg Asn Gly Arg Lys Thr Leu Thr Thr Val Gln 

        35                  40                  45              





Gly Ile Ala Asp Asp Tyr Asp Lys Lys Lys Leu Val Lys Ala Phe Lys 

    50                  55                  60                  





Lys Lys Phe Ala Cys Asn Gly Thr Val Ile Glu His Pro Glu Tyr Gly 

65                  70                  75                  80  





Glu Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Ile Cys Gln Phe 

                85                  90                  95      





Leu Val Glu Ile Gly Leu Ala Lys Asp Asp Gln Leu Lys Val His Gly 

            100                 105                 110         





Phe 

    





<210>  97

<211>  3818

<212>  DNA

<213>  Homo sapiens



<400>  97

caggaactgg gccagctccg gtcccttcct tttggggctc tcactctgga ggatggggtg       60



gatgggagaa aaaaccggga agatcctgac ggagttcctc cagttctatg aagaccagta      120



tggcgtggct ctcttcaaca gcatgcgcca tgagattgag ggcacggggc tgccgcaggc      180



ccagctgctc tggcgcaagg tgccactgga cgagcgcatc gtcttctcgg ggaacctctt      240



ccagcaccag gaggacagca agaagtggag aaaccgcttc agcctcgtgc cccacaacta      300



cgggctggtg ctctacgaaa acaaagcggc ctatgagcgg caggtcccac cacgagccgt      360



catcaacagt gcaggctaca aaatcctcac gtccgtggac caatacctgg agctcattgg      420



caactcctta ccagggacca cggcaaagtc gggcagtgcc cccatcctca agtgccccac      480



acagttcccg ctcatcctct ggcatcctta tgcgcgtcac tactacttct gcatgatgac      540



agaagccgag caggacaagt ggcaggctgt gctgcaggac tgcatccggc actgcaacaa      600



tggaatccct gaggactcca aggtagaggg ccctgcgttc acagatgcca tccgcatgta      660



ccgacagtcc aaggagctgt acggcacctg ggagatgctg tgtgggaacg aggtgcagat      720



cctgagcaac ctggtgatgg aggagctggg ccctgagctg aaggcagagc tcggcccgcg      780



gctgaagggg aaaccgcagg agcggcagcg gcagtggatc cagatctcgg acgccgtgta      840



ccacatggtg tacgagcagg ccaaggcgcg cttcgaggag gtgctgtcca aggtgcagca      900



ggtgcagccg gccatgcagg ccgtcatccg aactgacatg gaccaaatta tcacctccaa      960



ggagcacctt gccagcaaga tccgagcctt catcctcccc aaggcagagg tgtgcgtgcg     1020



gaaccatgtc cagccctaca tcccatccat cctggaggcc ctgatggtcc ccaccagcca     1080



gggcttcact gaggtgcgag atgtcttctt caaggaggtc acggacatga acctgaacgt     1140



catcaacgag ggcggcattg acaagctggg cgagtacatg gagaagctgt cccggctggc     1200



gtaccacccc ctgaagatgc agagctgcta tgagaagatg gagtcgctgc gactggacgg     1260



gctgcagcag cgatttgatg tgtccagcac gtccgtgttc aagcagcgag cccagatcca     1320



catgcgggag caaatggaca atgccgtgta tacgttcgag accctcctgc accaggagct     1380



ggggaagggg cccaccaagg aggagctgtg caagtccatc cagcgggtcc tggagcgggt     1440



gctgaagaaa tacgactacg acagcagctc tgtgcggaag aggttcttcc gggaggcgct     1500



gctgcagatc agcatcccgt tcctgctcaa gaagctggcc cctacctgca agtcggagct     1560



gccccggttc caggagctga tcttcgagga ctttgccagg ttcatcctgg tggaaaacac     1620



gtacgaggag gtggtgctgc agaccgtcat gaaggacatc ctgcaggctg tgaaggaggc     1680



cgcggtgcag aggaagcaca acctctaccg ggacagcatg gtcatgcaca acagcgaccc     1740



caacctgcac ctgctggccg agggcgcccc catcgactgg ggcgaggagt acagcaacag     1800



cggcgggggc ggcagcccca gccccagcac cccggagtca gccaccctct cggaaaagcg     1860



acggcgcgcc aagcaggtgg tctctgtggt ccaggatgag gaggtggggc tgccctttga     1920



ggctagccct gagtcaccac cacctgcgtc cccggacggt gtcactgaga tccgaggcct     1980



gctggcccaa ggtctgcggc ctgagagccc cccaccagcc ggccccctgc tcaacggggc     2040



ccccgctggg gagagtcccc agcctaaggc cgcccccgag gcctcctcgc cgcctgcctc     2100



acccctccag catctcctgc ctggaaaggc tgtggacctt gggcccccca agcccagcga     2160



ccaggagact ggagagcagg tgtccagccc cagcagccac cccgccctcc acaccaccac     2220



cgaggacagt gcaggggtgc agactgagtt ctaggccagt gggtccctga ctgctgcaca     2280



tggcacaggc cgttcccttc cggacccagg caggctcagc tctggggagg gcaccctggt     2340



ctgtgccttg tgggtggagg cggggcaggg ctgtgtggca ccgccaggga gcgggcccac     2400



ctgagtcact ttattgggtt cagtcaacac tttcttgctc cctgttttct cttctgtggg     2460



atgatctcag atgcaggggc tggttttggg gttttcctgc ttgtgccaag ggctggacac     2520



tgctgggggg ctggaaagcc cctcccttcc tgtccttctg tggcctccat cccctcatgg     2580



gtgctgccat ccttcctgga gagagggagg tgaaagctgg tgtgagccca gtgggttccc     2640



gcccactcac ccaggagctg gctgggccag gaccgggaga gggagcactg ctgccctcct     2700



ggccctgctc cttccgcagt taggggtgga ccgagcctcg ctttccccac tgttctggag     2760



ggaaggggaa ggagggggtc ttcaggctgg agccaggctg ggggtgctgg gtggagagat     2820



gagatttagg gggtgcctca tggggtgggc aggcctgggg tgaaatgaga aaggcccaga     2880



acgtgcaggt ctgcggaggg gaagtgtcct gagtgaagga ggggaccccc atcctggggg     2940



atgctgggag tgagtgagtg agatggctga gtgagggtta tggggagcct gaggttttat     3000



gggcctgtgt atccccttct cccggcccca gcctgcctcc ctcctgcccg cctggcccac     3060



aggtctccct ctggtccctg tccctctggt ggttggggat ggagcggcag caaggggtgt     3120



aatggggctg ggttctgtct tctacaggcc accccgaggt cctcagtggt tgcctgggga     3180



gccggacggg gctcctgagg ggtacaggtt gggtgggccc tccctgaggg tctggggtca     3240



ggctttggcc tctgctgcct ctcagtcacc aagtcacctc cctctgaaaa tccagtccct     3300



tctttggatg tccttgtgag tcactctggg cctggctgtc gtccctcctc agcttcttgt     3360



tcctgggaca agggtcaagc caggatgggc ccaggcctgg gatcccccac cccaggaccc     3420



ccaggccccc tcccctgctg ctttgcgggg ggcagggcag aaatggactc cttttgggtc     3480



cccgaggtgg ggtcccctcc cagccctgca tcctccgtgc cctagacctg ctccccagag     3540



gaggggcctt gacccacagg acgtgtggtg gcgcctggca ctcagggacc cccagctgcc     3600



gcagccctgg tctctggcgc atctcttccc tcttgtcccg aagatctgcg cctctagtgc     3660



cttttgaggg gttcccatca tccctccctg atattgtatt gaaaatatta tgcacactgt     3720



tcatgcttct actaatcaat aaacgcttta tttaaagcca aaaaaaaaaa aaaaaaaaaa     3780



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             3818





<210>  98

<211>  733

<212>  PRT

<213>  Homo sapiens



<400>  98



Met Gly Trp Met Gly Glu Lys Thr Gly Lys Ile Leu Thr Glu Phe Leu 

1               5                   10                  15      





Gln Phe Tyr Glu Asp Gln Tyr Gly Val Ala Leu Phe Asn Ser Met Arg 

            20                  25                  30          





His Glu Ile Glu Gly Thr Gly Leu Pro Gln Ala Gln Leu Leu Trp Arg 

        35                  40                  45              





Lys Val Pro Leu Asp Glu Arg Ile Val Phe Ser Gly Asn Leu Phe Gln 

    50                  55                  60                  





His Gln Glu Asp Ser Lys Lys Trp Arg Asn Arg Phe Ser Leu Val Pro 

65                  70                  75                  80  





His Asn Tyr Gly Leu Val Leu Tyr Glu Asn Lys Ala Ala Tyr Glu Arg 

                85                  90                  95      





Gln Val Pro Pro Arg Ala Val Ile Asn Ser Ala Gly Tyr Lys Ile Leu 

            100                 105                 110         





Thr Ser Val Asp Gln Tyr Leu Glu Leu Ile Gly Asn Ser Leu Pro Gly 

        115                 120                 125             





Thr Thr Ala Lys Ser Gly Ser Ala Pro Ile Leu Lys Cys Pro Thr Gln 

    130                 135                 140                 





Phe Pro Leu Ile Leu Trp His Pro Tyr Ala Arg His Tyr Tyr Phe Cys 

145                 150                 155                 160 





Met Met Thr Glu Ala Glu Gln Asp Lys Trp Gln Ala Val Leu Gln Asp 

                165                 170                 175     





Cys Ile Arg His Cys Asn Asn Gly Ile Pro Glu Asp Ser Lys Val Glu 

            180                 185                 190         





Gly Pro Ala Phe Thr Asp Ala Ile Arg Met Tyr Arg Gln Ser Lys Glu 

        195                 200                 205             





Leu Tyr Gly Thr Trp Glu Met Leu Cys Gly Asn Glu Val Gln Ile Leu 

    210                 215                 220                 





Ser Asn Leu Val Met Glu Glu Leu Gly Pro Glu Leu Lys Ala Glu Leu 

225                 230                 235                 240 





Gly Pro Arg Leu Lys Gly Lys Pro Gln Glu Arg Gln Arg Gln Trp Ile 

                245                 250                 255     





Gln Ile Ser Asp Ala Val Tyr His Met Val Tyr Glu Gln Ala Lys Ala 

            260                 265                 270         





Arg Phe Glu Glu Val Leu Ser Lys Val Gln Gln Val Gln Pro Ala Met 

        275                 280                 285             





Gln Ala Val Ile Arg Thr Asp Met Asp Gln Ile Ile Thr Ser Lys Glu 

    290                 295                 300                 





His Leu Ala Ser Lys Ile Arg Ala Phe Ile Leu Pro Lys Ala Glu Val 

305                 310                 315                 320 





Cys Val Arg Asn His Val Gln Pro Tyr Ile Pro Ser Ile Leu Glu Ala 

                325                 330                 335     





Leu Met Val Pro Thr Ser Gln Gly Phe Thr Glu Val Arg Asp Val Phe 

            340                 345                 350         





Phe Lys Glu Val Thr Asp Met Asn Leu Asn Val Ile Asn Glu Gly Gly 

        355                 360                 365             





Ile Asp Lys Leu Gly Glu Tyr Met Glu Lys Leu Ser Arg Leu Ala Tyr 

    370                 375                 380                 





His Pro Leu Lys Met Gln Ser Cys Tyr Glu Lys Met Glu Ser Leu Arg 

385                 390                 395                 400 





Leu Asp Gly Leu Gln Gln Arg Phe Asp Val Ser Ser Thr Ser Val Phe 

                405                 410                 415     





Lys Gln Arg Ala Gln Ile His Met Arg Glu Gln Met Asp Asn Ala Val 

            420                 425                 430         





Tyr Thr Phe Glu Thr Leu Leu His Gln Glu Leu Gly Lys Gly Pro Thr 

        435                 440                 445             





Lys Glu Glu Leu Cys Lys Ser Ile Gln Arg Val Leu Glu Arg Val Leu 

    450                 455                 460                 





Lys Lys Tyr Asp Tyr Asp Ser Ser Ser Val Arg Lys Arg Phe Phe Arg 

465                 470                 475                 480 





Glu Ala Leu Leu Gln Ile Ser Ile Pro Phe Leu Leu Lys Lys Leu Ala 

                485                 490                 495     





Pro Thr Cys Lys Ser Glu Leu Pro Arg Phe Gln Glu Leu Ile Phe Glu 

            500                 505                 510         





Asp Phe Ala Arg Phe Ile Leu Val Glu Asn Thr Tyr Glu Glu Val Val 

        515                 520                 525             





Leu Gln Thr Val Met Lys Asp Ile Leu Gln Ala Val Lys Glu Ala Ala 

    530                 535                 540                 





Val Gln Arg Lys His Asn Leu Tyr Arg Asp Ser Met Val Met His Asn 

545                 550                 555                 560 





Ser Asp Pro Asn Leu His Leu Leu Ala Glu Gly Ala Pro Ile Asp Trp 

                565                 570                 575     





Gly Glu Glu Tyr Ser Asn Ser Gly Gly Gly Gly Ser Pro Ser Pro Ser 

            580                 585                 590         





Thr Pro Glu Ser Ala Thr Leu Ser Glu Lys Arg Arg Arg Ala Lys Gln 

        595                 600                 605             





Val Val Ser Val Val Gln Asp Glu Glu Val Gly Leu Pro Phe Glu Ala 

    610                 615                 620                 





Ser Pro Glu Ser Pro Pro Pro Ala Ser Pro Asp Gly Val Thr Glu Ile 

625                 630                 635                 640 





Arg Gly Leu Leu Ala Gln Gly Leu Arg Pro Glu Ser Pro Pro Pro Ala 

                645                 650                 655     





Gly Pro Leu Leu Asn Gly Ala Pro Ala Gly Glu Ser Pro Gln Pro Lys 

            660                 665                 670         





Ala Ala Pro Glu Ala Ser Ser Pro Pro Ala Ser Pro Leu Gln His Leu 

        675                 680                 685             





Leu Pro Gly Lys Ala Val Asp Leu Gly Pro Pro Lys Pro Ser Asp Gln 

    690                 695                 700                 





Glu Thr Gly Glu Gln Val Ser Ser Pro Ser Ser His Pro Ala Leu His 

705                 710                 715                 720 





Thr Thr Thr Glu Asp Ser Ala Gly Val Gln Thr Glu Phe 

                725                 730             





<210>  99

<211>  4007

<212>  DNA

<213>  Homo sapiens



<400>  99

gccaaggcgg ccggctggag ggacggggcc cgaccgggag cggagccgga gcggaagccg       60



cagccgggcg gcgggagcgg cgggagcggc gggagcgggg gaagcagggc gggccgggct      120



ccatggcgcc agcggcgtcc gcctgagcag cgcgggcaac agcggcggcg tcggccggat      180



cgggccgcga cacctcctgg ccatggggga cgtgctgtcc acgcacctgg acgacgcccg      240



gcgccagcac atcgcagaaa aaaccgggaa gatcctgacg gagttcctcc agttctatga      300



agaccagtat ggcgtggctc tcttcaacag catgcgccat gagattgagg gcacggggct      360



gccgcaggcc cagctgctct ggcgcaaggt gccactggac gagcgcatcg tcttctcggg      420



gaacctcttc cagcaccagg aggacagcaa gaagtggaga aaccgcttca gcctcgtgcc      480



ccacaactac gggctggtgc tctacgaaaa caaagcggcc tatgagcggc aggtcccacc      540



acgagccgtc atcaacagtg caggctacaa aatcctcacg tccgtggacc aatacctgga      600



gctcattggc aactccttac cagggaccac ggcaaagtcg ggcagtgccc ccatcctcaa      660



gtgccccaca cagttcccgc tcatcctctg gcatccttat gcgcgtcact actacttctg      720



catgatgaca gaagccgagc aggacaagtg gcaggctgtg ctgcaggact gcatccggca      780



ctgcaacaat ggaatccctg aggactccaa ggtagagggc cctgcgttca cagatgccat      840



ccgcatgtac cgacagtcca aggagctgta cggcacctgg gagatgctgt gtgggaacga      900



ggtgcagatc ctgagcaacc tggtgatgga ggagctgggc cctgagctga aggcagagct      960



cggcccgcgg ctgaagggga aaccgcagga gcggcagcgg cagtggatcc agatctcgga     1020



cgccgtgtac cacatggtgt acgagcaggc caaggcgcgc ttcgaggagg tgctgtccaa     1080



ggtgcagcag gtgcagccgg ccatgcaggc cgtcatccga actgacatgg accaaattat     1140



cacctccaag gagcaccttg ccagcaagat ccgagccttc atcctcccca aggcagaggt     1200



gtgcgtgcgg aaccatgtcc agccctacat cccatccatc ctggaggccc tgatggtccc     1260



caccagccag ggcttcactg aggtgcgaga tgtcttcttc aaggaggtca cggacatgaa     1320



cctgaacgtc atcaacgagg gcggcattga caagctgggc gagtacatgg agaagctgtc     1380



ccggctggcg taccaccccc tgaagatgca gagctgctat gagaagatgg agtcgctgcg     1440



actggacggg ctgcagcagc gatttgatgt gtccagcacg tccgtgttca agcagcgagc     1500



ccagatccac atgcgggagc aaatggacaa tgccgtgtat acgttcgaga ccctcctgca     1560



ccaggagctg gggaaggggc ccaccaagga ggagctgtgc aagtccatcc agcgggtcct     1620



ggagcgggtg ctgaagaaat acgactacga cagcagctct gtgcggaaga ggttcttccg     1680



ggaggcgctg ctgcagatca gcatcccgtt cctgctcaag aagctggccc ctacctgcaa     1740



gtcggagctg ccccggttcc aggagctgat cttcgaggac tttgccaggt tcatcctggt     1800



ggaaaacacg tacgaggagg tggtgctgca gaccgtcatg aaggacatcc tgcaggctgt     1860



gaaggaggcc gcggtgcaga ggaagcacaa cctctaccgg gacagcatgg tcatgcacaa     1920



cagcgacccc aacctgcacc tgctggccga gggcgccccc atcgactggg gcgaggagta     1980



cagcaacagc ggcgggggcg gcagccccag ccccagcacc ccggagtcag ccaccctctc     2040



ggaaaagcga cggcgcgcca agcaggtggt ctctgtggtc caggatgagg aggtggggct     2100



gccctttgag gctagccctg agtcaccacc acctgcgtcc ccggacggtg tcactgagat     2160



ccgaggcctg ctggcccaag gtctgcggcc tgagagcccc ccaccagccg gccccctgct     2220



caacggggcc cccgctgggg agagtcccca gcctaaggcc gcccccgagg cctcctcgcc     2280



gcctgcctca cccctccagc atctcctgcc tggaaaggct gtggaccttg ggccccccaa     2340



gcccagcgac caggagactg gagagcaggt gtccagcccc agcagccacc ccgccctcca     2400



caccaccacc gaggacagtg caggggtgca gactgagttc taggccagtg ggtccctgac     2460



tgctgcacat ggcacaggcc gttcccttcc ggacccaggc aggctcagct ctggggaggg     2520



caccctggtc tgtgccttgt gggtggaggc ggggcagggc tgtgtggcac cgccagggag     2580



cgggcccacc tgagtcactt tattgggttc agtcaacact ttcttgctcc ctgttttctc     2640



ttctgtggga tgatctcaga tgcaggggct ggttttgggg ttttcctgct tgtgccaagg     2700



gctggacact gctggggggc tggaaagccc ctcccttcct gtccttctgt ggcctccatc     2760



ccctcatggg tgctgccatc cttcctggag agagggaggt gaaagctggt gtgagcccag     2820



tgggttcccg cccactcacc caggagctgg ctgggccagg accgggagag ggagcactgc     2880



tgccctcctg gccctgctcc ttccgcagtt aggggtggac cgagcctcgc tttccccact     2940



gttctggagg gaaggggaag gagggggtct tcaggctgga gccaggctgg gggtgctggg     3000



tggagagatg agatttaggg ggtgcctcat ggggtgggca ggcctggggt gaaatgagaa     3060



aggcccagaa cgtgcaggtc tgcggagggg aagtgtcctg agtgaaggag gggaccccca     3120



tcctggggga tgctgggagt gagtgagtga gatggctgag tgagggttat ggggagcctg     3180



aggttttatg ggcctgtgta tccccttctc ccggccccag cctgcctccc tcctgcccgc     3240



ctggcccaca ggtctccctc tggtccctgt ccctctggtg gttggggatg gagcggcagc     3300



aaggggtgta atggggctgg gttctgtctt ctacaggcca ccccgaggtc ctcagtggtt     3360



gcctggggag ccggacgggg ctcctgaggg gtacaggttg ggtgggccct ccctgagggt     3420



ctggggtcag gctttggcct ctgctgcctc tcagtcacca agtcacctcc ctctgaaaat     3480



ccagtccctt ctttggatgt ccttgtgagt cactctgggc ctggctgtcg tccctcctca     3540



gcttcttgtt cctgggacaa gggtcaagcc aggatgggcc caggcctggg atcccccacc     3600



ccaggacccc caggccccct cccctgctgc tttgcggggg gcagggcaga aatggactcc     3660



ttttgggtcc ccgaggtggg gtcccctccc agccctgcat cctccgtgcc ctagacctgc     3720



tccccagagg aggggccttg acccacagga cgtgtggtgg cgcctggcac tcagggaccc     3780



ccagctgccg cagccctggt ctctggcgca tctcttccct cttgtcccga agatctgcgc     3840



ctctagtgcc ttttgagggg ttcccatcat ccctccctga tattgtattg aaaatattat     3900



gcacactgtt catgcttcta ctaatcaata aacgctttat ttaaagccaa aaaaaaaaaa     3960



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   4007





<210>  100

<211>  746

<212>  PRT

<213>  Homo sapiens



<400>  100



Met Gly Asp Val Leu Ser Thr His Leu Asp Asp Ala Arg Arg Gln His 

1               5                   10                  15      





Ile Ala Glu Lys Thr Gly Lys Ile Leu Thr Glu Phe Leu Gln Phe Tyr 

            20                  25                  30          





Glu Asp Gln Tyr Gly Val Ala Leu Phe Asn Ser Met Arg His Glu Ile 

        35                  40                  45              





Glu Gly Thr Gly Leu Pro Gln Ala Gln Leu Leu Trp Arg Lys Val Pro 

    50                  55                  60                  





Leu Asp Glu Arg Ile Val Phe Ser Gly Asn Leu Phe Gln His Gln Glu 

65                  70                  75                  80  





Asp Ser Lys Lys Trp Arg Asn Arg Phe Ser Leu Val Pro His Asn Tyr 

                85                  90                  95      





Gly Leu Val Leu Tyr Glu Asn Lys Ala Ala Tyr Glu Arg Gln Val Pro 

            100                 105                 110         





Pro Arg Ala Val Ile Asn Ser Ala Gly Tyr Lys Ile Leu Thr Ser Val 

        115                 120                 125             





Asp Gln Tyr Leu Glu Leu Ile Gly Asn Ser Leu Pro Gly Thr Thr Ala 

    130                 135                 140                 





Lys Ser Gly Ser Ala Pro Ile Leu Lys Cys Pro Thr Gln Phe Pro Leu 

145                 150                 155                 160 





Ile Leu Trp His Pro Tyr Ala Arg His Tyr Tyr Phe Cys Met Met Thr 

                165                 170                 175     





Glu Ala Glu Gln Asp Lys Trp Gln Ala Val Leu Gln Asp Cys Ile Arg 

            180                 185                 190         





His Cys Asn Asn Gly Ile Pro Glu Asp Ser Lys Val Glu Gly Pro Ala 

        195                 200                 205             





Phe Thr Asp Ala Ile Arg Met Tyr Arg Gln Ser Lys Glu Leu Tyr Gly 

    210                 215                 220                 





Thr Trp Glu Met Leu Cys Gly Asn Glu Val Gln Ile Leu Ser Asn Leu 

225                 230                 235                 240 





Val Met Glu Glu Leu Gly Pro Glu Leu Lys Ala Glu Leu Gly Pro Arg 

                245                 250                 255     





Leu Lys Gly Lys Pro Gln Glu Arg Gln Arg Gln Trp Ile Gln Ile Ser 

            260                 265                 270         





Asp Ala Val Tyr His Met Val Tyr Glu Gln Ala Lys Ala Arg Phe Glu 

        275                 280                 285             





Glu Val Leu Ser Lys Val Gln Gln Val Gln Pro Ala Met Gln Ala Val 

    290                 295                 300                 





Ile Arg Thr Asp Met Asp Gln Ile Ile Thr Ser Lys Glu His Leu Ala 

305                 310                 315                 320 





Ser Lys Ile Arg Ala Phe Ile Leu Pro Lys Ala Glu Val Cys Val Arg 

                325                 330                 335     





Asn His Val Gln Pro Tyr Ile Pro Ser Ile Leu Glu Ala Leu Met Val 

            340                 345                 350         





Pro Thr Ser Gln Gly Phe Thr Glu Val Arg Asp Val Phe Phe Lys Glu 

        355                 360                 365             





Val Thr Asp Met Asn Leu Asn Val Ile Asn Glu Gly Gly Ile Asp Lys 

    370                 375                 380                 





Leu Gly Glu Tyr Met Glu Lys Leu Ser Arg Leu Ala Tyr His Pro Leu 

385                 390                 395                 400 





Lys Met Gln Ser Cys Tyr Glu Lys Met Glu Ser Leu Arg Leu Asp Gly 

                405                 410                 415     





Leu Gln Gln Arg Phe Asp Val Ser Ser Thr Ser Val Phe Lys Gln Arg 

            420                 425                 430         





Ala Gln Ile His Met Arg Glu Gln Met Asp Asn Ala Val Tyr Thr Phe 

        435                 440                 445             





Glu Thr Leu Leu His Gln Glu Leu Gly Lys Gly Pro Thr Lys Glu Glu 

    450                 455                 460                 





Leu Cys Lys Ser Ile Gln Arg Val Leu Glu Arg Val Leu Lys Lys Tyr 

465                 470                 475                 480 





Asp Tyr Asp Ser Ser Ser Val Arg Lys Arg Phe Phe Arg Glu Ala Leu 

                485                 490                 495     





Leu Gln Ile Ser Ile Pro Phe Leu Leu Lys Lys Leu Ala Pro Thr Cys 

            500                 505                 510         





Lys Ser Glu Leu Pro Arg Phe Gln Glu Leu Ile Phe Glu Asp Phe Ala 

        515                 520                 525             





Arg Phe Ile Leu Val Glu Asn Thr Tyr Glu Glu Val Val Leu Gln Thr 

    530                 535                 540                 





Val Met Lys Asp Ile Leu Gln Ala Val Lys Glu Ala Ala Val Gln Arg 

545                 550                 555                 560 





Lys His Asn Leu Tyr Arg Asp Ser Met Val Met His Asn Ser Asp Pro 

                565                 570                 575     





Asn Leu His Leu Leu Ala Glu Gly Ala Pro Ile Asp Trp Gly Glu Glu 

            580                 585                 590         





Tyr Ser Asn Ser Gly Gly Gly Gly Ser Pro Ser Pro Ser Thr Pro Glu 

        595                 600                 605             





Ser Ala Thr Leu Ser Glu Lys Arg Arg Arg Ala Lys Gln Val Val Ser 

    610                 615                 620                 





Val Val Gln Asp Glu Glu Val Gly Leu Pro Phe Glu Ala Ser Pro Glu 

625                 630                 635                 640 





Ser Pro Pro Pro Ala Ser Pro Asp Gly Val Thr Glu Ile Arg Gly Leu 

                645                 650                 655     





Leu Ala Gln Gly Leu Arg Pro Glu Ser Pro Pro Pro Ala Gly Pro Leu 

            660                 665                 670         





Leu Asn Gly Ala Pro Ala Gly Glu Ser Pro Gln Pro Lys Ala Ala Pro 

        675                 680                 685             





Glu Ala Ser Ser Pro Pro Ala Ser Pro Leu Gln His Leu Leu Pro Gly 

    690                 695                 700                 





Lys Ala Val Asp Leu Gly Pro Pro Lys Pro Ser Asp Gln Glu Thr Gly 

705                 710                 715                 720 





Glu Gln Val Ser Ser Pro Ser Ser His Pro Ala Leu His Thr Thr Thr 

                725                 730                 735     





Glu Asp Ser Ala Gly Val Gln Thr Glu Phe 

            740                 745     





<210>  101

<211>  1552

<212>  DNA

<213>  Homo sapiens



<400>  101

gtgcatctcc ttatatggtc aaatgacacg gcggggtttc tcgagggcgg gagctgcgca       60



gcgctccact cggccggcag cggagccgca gccaccagcc gcccgcgccc tccagccccg      120



tccgggagtc cccggcccgc tgcggtgcct ggctgagaac tgtgtcttcc tggagactag      180



gctggcattt tgactttggg gttgctgaaa agccaggagt caaaatgact gagcgctttg      240



actgccacca ttgcaacgaa tctctctttg gcaagaagta catcctgcgg gaggagagcc      300



cctactgcgt ggtgtgcttt gagaccctgt tcgccaacac ctgcgaggag tgtgggaagc      360



ccatcggctg tgactgcaag gacttgtctt acaaggaccg gcactggcat gaagcctgtt      420



tccactgctc gcagtgcaga aactcactgg tggacaagcc ctttgctgcc aaggaggacc      480



agctgctctg tacagactgc tattccaacg agtactcatc caagtgccag gaatgcaaga      540



agaccatcat gccaggtacc cgcaagatgg agtacaaggg cagcagctgg catgagacct      600



gcttcatctg ccaccgctgc cagcagccaa ttggaaccaa gagtttcatc cccaaagaca      660



atcagaattt ctgtgtgccc tgctatgaga aacaacatgc catgcagtgc gttcagtgca      720



aaaagcccat caccacggga ggggtcactt accgggagca gccctggcac aaggagtgct      780



tcgtgtgcac cgcctgcagg aagcagctgt ctgggcagcg cttcacagct cgcgatgact      840



ttgcctactg cctgaactgc ttctgtgact tgtatgccaa gaagtgtgct gggtgcacca      900



accccatcag cggacttggt ggcacaaaat acatctcctt tgaggaacgg cagtggcata      960



acgactgctt taactgtaag aagtgctccc tctcactggt ggggcgtggc ttcctcacag     1020



agagggacga catcctgtgc cccgactgtg ggaaagacat ctgaattcaa cacagagaag     1080



ttgctgcttg tgatctcaca cacagatttt tatgttttct ttctcaccca ggcaatcttg     1140



ccttctggtt tcttccagcc acattgagac tttcttctag tgcttttcag tgatactcac     1200



gtttgcttaa accctttagt gctttgtgat agttcagtcc cagggaaaga gaaaactcgc     1260



cctaggccct aggtgggaag atggtttgaa atttttgtaa tcgagtaagg cacacccaaa     1320



tgtaaaaatc cttttgaatg atgcctttat aaatctttct ctcactgtct atttaagtgc     1380



aattaacata tgtcacgaac ttgaaagttt tctaaactca ataaggtaat gaccagttgt     1440



tatttacagc tctgtaacct cccgttgcgt caagtctaaa ccaagattat gtgacttgca     1500



ataaagttat tcagaacaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1552





<210>  102

<211>  279

<212>  PRT

<213>  Homo sapiens



<400>  102



Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly 

1               5                   10                  15      





Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe 

            20                  25                  30          





Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly 

        35                  40                  45              





Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala 

    50                  55                  60                  





Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe 

65                  70                  75                  80  





Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu 

                85                  90                  95      





Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr 

            100                 105                 110         





Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile 

        115                 120                 125             





Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys 

    130                 135                 140                 





Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met 

145                 150                 155                 160 





Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr 

                165                 170                 175     





Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg 

            180                 185                 190         





Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr 

        195                 200                 205             





Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys 

    210                 215                 220                 





Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu 

225                 230                 235                 240 





Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu 

                245                 250                 255     





Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys 

            260                 265                 270         





Pro Asp Cys Gly Lys Asp Ile 

        275                 





<210>  103

<211>  1735

<212>  DNA

<213>  Homo sapiens



<400>  103

agggtacggg ccgggaccgc cgcagcccgg ggcgggggca cggcaaccgc gaggcctggg       60



ggcgcccgcc ccccgcgccc cacgcccggt gccagcgagc cgaggcgtgc atctccttat      120



atggtcaaat gacacggcgg ggtttctcga gggcgggagc tgcgcagcgc tccactcggc      180



cggcagcgga gccgcagcca ccagccgccc gcgccctcca gccccgtccg ggagtccccg      240



gcccgctgcg gtgccgtgag tacctccaac cccctgcgcc ccggagggag gccgaggggc      300



ttagccacca gggctcggaa gtgggggccg aatccggtgc gagacccaag gagaggggag      360



cagagccgga gttggggaga ctggttgctg aaaagccagg agtcaaaatg actgagcgct      420



ttgactgcca ccattgcaac gaatctctct ttggcaagaa gtacatcctg cgggaggaga      480



gcccctactg cgtggtgtgc tttgagaccc tgttcgccaa cacctgcgag gagtgtggga      540



agcccatcgg ctgtgactgc aaggacttgt cttacaagga ccggcactgg catgaagcct      600



gtttccactg ctcgcagtgc agaaactcac tggtggacaa gccctttgct gccaaggagg      660



accagctgct ctgtacagac tgctattcca acgagtactc atccaagtgc caggaatgca      720



agaagaccat catgccaggt acccgcaaga tggagtacaa gggcagcagc tggcatgaga      780



cctgcttcat ctgccaccgc tgccagcagc caattggaac caagagtttc atccccaaag      840



acaatcagaa tttctgtgtg ccctgctatg agaaacaaca tgccatgcag tgcgttcagt      900



gcaaaaagcc catcaccacg ggaggggtca cttaccggga gcagccctgg cacaaggagt      960



gcttcgtgtg caccgcctgc aggaagcagc tgtctgggca gcgcttcaca gctcgcgatg     1020



actttgccta ctgcctgaac tgcttctgtg acttgtatgc caagaagtgt gctgggtgca     1080



ccaaccccat cagcggactt ggtggcacaa aatacatctc ctttgaggaa cggcagtggc     1140



ataacgactg ctttaactgt aagaagtgct ccctctcact ggtggggcgt ggcttcctca     1200



cagagaggga cgacatcctg tgccccgact gtgggaaaga catctgaatt caacacagag     1260



aagttgctgc ttgtgatctc acacacagat ttttatgttt tctttctcac ccaggcaatc     1320



ttgccttctg gtttcttcca gccacattga gactttcttc tagtgctttt cagtgatact     1380



cacgtttgct taaacccttt agtgctttgt gatagttcag tcccagggaa agagaaaact     1440



cgccctaggc cctaggtggg aagatggttt gaaatttttg taatcgagta aggcacaccc     1500



aaatgtaaaa atccttttga atgatgcctt tataaatctt tctctcactg tctatttaag     1560



tgcaattaac atatgtcacg aacttgaaag ttttctaaac tcaataaggt aatgaccagt     1620



tgttatttac agctctgtaa cctcccgttg cgtcaagtct aaaccaagat tatgtgactt     1680



gcaataaagt tattcagaac agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          1735





<210>  104

<211>  279

<212>  PRT

<213>  Homo sapiens



<400>  104



Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly 

1               5                   10                  15      





Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe 

            20                  25                  30          





Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly 

        35                  40                  45              





Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala 

    50                  55                  60                  





Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe 

65                  70                  75                  80  





Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu 

                85                  90                  95      





Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr 

            100                 105                 110         





Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile 

        115                 120                 125             





Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys 

    130                 135                 140                 





Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met 

145                 150                 155                 160 





Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr 

                165                 170                 175     





Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg 

            180                 185                 190         





Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr 

        195                 200                 205             





Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys 

    210                 215                 220                 





Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu 

225                 230                 235                 240 





Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu 

                245                 250                 255     





Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys 

            260                 265                 270         





Pro Asp Cys Gly Lys Asp Ile 

        275                 





<210>  105

<211>  1907

<212>  DNA

<213>  Homo sapiens



<400>  105

agggtacggg ccgggaccgc cgcagcccgg ggcgggggca cggcaaccgc gaggcctggg       60



ggcgcccgcc ccccgcgccc cacgcccggt gccagcgagc cgaggcgtgc atctccttat      120



atggtcaaat gacacggcgg ggtttctcga gggcgggagc tgcgcagcgc tccactcggc      180



cggcagcgga gccgcagcca ccagccgccc gcgccctcca gccccgtccg ggagtccccg      240



gcccgctgcg gtgccgtgag tacctccaac cccctgcgcc ccggagggag gccgaggggc      300



ttagccacca gggctcggaa gtgggggccg aatccggtgc gagacccaag gagaggggag      360



cagagccgga gttggggaga ctgtggctga gaactgtgtc ttcctggaga ctaggctggc      420



attttgactt tgggacggag tctcgctttg tcgcccaggc tggagtgcag tggcacgatc      480



tcagctcact gcaagctcta cctcttggtt cacgccattc tcctgcccca gcctcccaag      540



tagctgggac tacaggttgc tgaaaagcca ggagtcaaaa tgactgagcg ctttgactgc      600



caccattgca acgaatctct ctttggcaag aagtacatcc tgcgggagga gagcccctac      660



tgcgtggtgt gctttgagac cctgttcgcc aacacctgcg aggagtgtgg gaagcccatc      720



ggctgtgact gcaaggactt gtcttacaag gaccggcact ggcatgaagc ctgtttccac      780



tgctcgcagt gcagaaactc actggtggac aagccctttg ctgccaagga ggaccagctg      840



ctctgtacag actgctattc caacgagtac tcatccaagt gccaggaatg caagaagacc      900



atcatgccag gtacccgcaa gatggagtac aagggcagca gctggcatga gacctgcttc      960



atctgccacc gctgccagca gccaattgga accaagagtt tcatccccaa agacaatcag     1020



aatttctgtg tgccctgcta tgagaaacaa catgccatgc agtgcgttca gtgcaaaaag     1080



cccatcacca cgggaggggt cacttaccgg gagcagccct ggcacaagga gtgcttcgtg     1140



tgcaccgcct gcaggaagca gctgtctggg cagcgcttca cagctcgcga tgactttgcc     1200



tactgcctga actgcttctg tgacttgtat gccaagaagt gtgctgggtg caccaacccc     1260



atcagcggac ttggtggcac aaaatacatc tcctttgagg aacggcagtg gcataacgac     1320



tgctttaact gtaagaagtg ctccctctca ctggtggggc gtggcttcct cacagagagg     1380



gacgacatcc tgtgccccga ctgtgggaaa gacatctgaa ttcaacacag agaagttgct     1440



gcttgtgatc tcacacacag atttttatgt tttctttctc acccaggcaa tcttgccttc     1500



tggtttcttc cagccacatt gagactttct tctagtgctt ttcagtgata ctcacgtttg     1560



cttaaaccct ttagtgcttt gtgatagttc agtcccaggg aaagagaaaa ctcgccctag     1620



gccctaggtg ggaagatggt ttgaaatttt tgtaatcgag taaggcacac ccaaatgtaa     1680



aaatcctttt gaatgatgcc tttataaatc tttctctcac tgtctattta agtgcaatta     1740



acatatgtca cgaacttgaa agttttctaa actcaataag gtaatgacca gttgttattt     1800



acagctctgt aacctcccgt tgcgtcaagt ctaaaccaag attatgtgac ttgcaataaa     1860



gttattcaga acagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   1907





<210>  106

<211>  279

<212>  PRT

<213>  Homo sapiens



<400>  106



Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly 

1               5                   10                  15      





Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe 

            20                  25                  30          





Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly 

        35                  40                  45              





Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala 

    50                  55                  60                  





Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe 

65                  70                  75                  80  





Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu 

                85                  90                  95      





Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr 

            100                 105                 110         





Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile 

        115                 120                 125             





Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys 

    130                 135                 140                 





Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met 

145                 150                 155                 160 





Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr 

                165                 170                 175     





Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg 

            180                 185                 190         





Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr 

        195                 200                 205             





Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys 

    210                 215                 220                 





Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu 

225                 230                 235                 240 





Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu 

                245                 250                 255     





Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys 

            260                 265                 270         





Pro Asp Cys Gly Lys Asp Ile 

        275                 





<210>  107

<211>  1727

<212>  DNA

<213>  Homo sapiens



<400>  107

aaagtgaggt ccctttctgg tgctggtggc cttcccagtt tagccaccct ttggattcct       60



ggaaaatatg aggcctcgtg tgtccttgaa gcaggcagga caaacgagga catggcagcc      120



ccttcccatc tgggagctga ggcttcttta atctggagac cttaaaaggc acgtgggagc      180



caggggctgg gttcttatct cctaggcctg gccaatgtcc agacgtgcct tatttatagc      240



gccactgaca agggcagcgc agctggctgg cagctgcaca gaaggttggg gccatccaac      300



caggcagtcc gcctgcacag cagctgtccc tgctcatcgg gctggaggac agaagacaga      360



accctaaaac cacaggttgc tgaaaagcca ggagtcaaaa tgactgagcg ctttgactgc      420



caccattgca acgaatctct ctttggcaag aagtacatcc tgcgggagga gagcccctac      480



tgcgtggtgt gctttgagac cctgttcgcc aacacctgcg aggagtgtgg gaagcccatc      540



ggctgtgact gcaaggactt gtcttacaag gaccggcact ggcatgaagc ctgtttccac      600



tgctcgcagt gcagaaactc actggtggac aagccctttg ctgccaagga ggaccagctg      660



ctctgtacag actgctattc caacgagtac tcatccaagt gccaggaatg caagaagacc      720



atcatgccag gtacccgcaa gatggagtac aagggcagca gctggcatga gacctgcttc      780



atctgccacc gctgccagca gccaattgga accaagagtt tcatccccaa agacaatcag      840



aatttctgtg tgccctgcta tgagaaacaa catgccatgc agtgcgttca gtgcaaaaag      900



cccatcacca cgggaggggt cacttaccgg gagcagccct ggcacaagga gtgcttcgtg      960



tgcaccgcct gcaggaagca gctgtctggg cagcgcttca cagctcgcga tgactttgcc     1020



tactgcctga actgcttctg tgacttgtat gccaagaagt gtgctgggtg caccaacccc     1080



atcagcggac ttggtggcac aaaatacatc tcctttgagg aacggcagtg gcataacgac     1140



tgctttaact gtaagaagtg ctccctctca ctggtggggc gtggcttcct cacagagagg     1200



gacgacatcc tgtgccccga ctgtgggaaa gacatctgaa ttcaacacag agaagttgct     1260



gcttgtgatc tcacacacag atttttatgt tttctttctc acccaggcaa tcttgccttc     1320



tggtttcttc cagccacatt gagactttct tctagtgctt ttcagtgata ctcacgtttg     1380



cttaaaccct ttagtgcttt gtgatagttc agtcccaggg aaagagaaaa ctcgccctag     1440



gccctaggtg ggaagatggt ttgaaatttt tgtaatcgag taaggcacac ccaaatgtaa     1500



aaatcctttt gaatgatgcc tttataaatc tttctctcac tgtctattta agtgcaatta     1560



acatatgtca cgaacttgaa agttttctaa actcaataag gtaatgacca gttgttattt     1620



acagctctgt aacctcccgt tgcgtcaagt ctaaaccaag attatgtgac ttgcaataaa     1680



gttattcaga acagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   1727





<210>  108

<211>  279

<212>  PRT

<213>  Homo sapiens



<400>  108



Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly 

1               5                   10                  15      





Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe 

            20                  25                  30          





Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly 

        35                  40                  45              





Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala 

    50                  55                  60                  





Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe 

65                  70                  75                  80  





Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu 

                85                  90                  95      





Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr 

            100                 105                 110         





Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile 

        115                 120                 125             





Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys 

    130                 135                 140                 





Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met 

145                 150                 155                 160 





Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr 

                165                 170                 175     





Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg 

            180                 185                 190         





Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr 

        195                 200                 205             





Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys 

    210                 215                 220                 





Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu 

225                 230                 235                 240 





Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu 

                245                 250                 255     





Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys 

            260                 265                 270         





Pro Asp Cys Gly Lys Asp Ile 

        275                 





<210>  109

<211>  607

<212>  DNA

<213>  Homo sapiens



<400>  109

atgactctta acgagcatgc tgccttcaag catctgttta acaaagcaca tcttgcaccg       60



cccttaatcc atttaaccct gagtggacac agcacatgtt tcagagagca cagggttggg      120



ggtaaggtca cagatcaaca ggatcccaag gcagaggaat ttttcttagt gcagaacaaa      180



atgaaaagtc tcccatgtct acttctttct acacagacac ggcaaccatc cgatttctca      240



atcttttccc cacctttccc gcctttctat tccacaaagc cgccattgtc atcctggccc      300



gttctcaatg agctgttggg cacacctccc agacggggtg gtggccgggc agaggggctc      360



ctcacttccc agtaggggcg gccgggcaga ggcgcccctc acctcccgga cagggcggct      420



ggggcggccg ggcagaggcg cccctcacct cccggacagg gcggctgggc ggctggccgg      480



gcagaggggc tcctcacttc ccagtagggg cggctgggca gaggggctcc tcacttccca      540



gtaggggcgg ccgggcagag gcgcccctca cctcccggac ggggcggctg gccgggcggg      600



gggctga                                                                607





<210>  110

<211>  4127

<212>  DNA

<213>  Homo sapiens



<400>  110

gtgctccgct ggttgaaagc ggatccgggc tggaggcggt gtcacggtgt atgaatattg       60



attacgcgtc gcagcgccca gggcccagcg cccagcctcc agtgcccgcc cctctcggcc      120



gcccgacgct ctctgctcgc gcttgggctc gcgatgggga agaagtcccg ggcggtaccc      180



ggccgtaggc ccatcctgca actctctccg ccgggtcctc ggggcagcac gccgggccgg      240



gacccggagc cggaacccga cactgagccg gactcaaccg cggcggtccc cagccagccc      300



gccccgtcgg cggcgacgac caccaccacc gcggtgactg ccgccgcggc ctcggacgac      360



tcgccttcag aagatgaaca ggaagcggtg caggaggttc ctagagttgt tcagaatcct      420



ccaaaaccag tcatgaccac tagacccaca gctgttaaag caacaggcgg tctatgcttg      480



cttggtgctt atgctgacag tgatgacgat gacaatgatg tttccgaaaa actagcacaa      540



tccaaagaga caaatggaaa ccagtcaact gatattgata gtacattggc caacttccta      600



gcggagatcg atgccataac agctcctcag cctgcagctc ctgtaggagc ttctgctcca      660



cctccaactc cacctcgacc agagccaaag gaagcagcaa catctaccct ttcttcttct      720



acttcaaatg gaacagactc cacccaaaca tctggttggc aatatgatac tcagtgttca      780



ctggcaggag tcggaattga gatgggcgat tggcaggaag tctgggatga gaacacggga      840



tgttattatt attggaatac acaaacaaat gaagtgactt gggagttacc ccaatatctt      900



gccacacagg tacagggatt acagcattac cagcccagtt ctgtgccagg tgctgaaact      960



agttttgtgg taaatacaga catatattct aaggagaaaa cgatttctgt ttccagtagt     1020



aaaagtggac cagtcatagc caagcgagaa gttaaaaagg aagtaaatga aggaattcag     1080



gctctctcaa atagtgagga ggagaagaaa ggggtggcag catcgctgct tgctccttta     1140



ttgcctgagg gaataaaaga agaagaagag agatggagaa gaaaagtaat ttgtaaagag     1200



gagccagttt cagaagtaaa agaaacaagt acaacagtag aagaagcaac aacaatagta     1260



aagccacagg aaattatgtt ggacaatata gaagaccctt ctcaggagga tctttgcagt     1320



gttgtccaat ctggagaaag tgaggaggaa gaggaacaag atacccttga actggagcta     1380



gttttggaaa ggaaaaaagc agagttgcga gccttggagg aaggagatgg tagtgtgtca     1440



gggtctagtc cacgttctga tatcagccag ccagcatctc aagatggaat gcgtaggctt     1500



atgtctaaaa gaggaaaatg gaagatgttt gttcgagcta ccagtccaga atctaccagt     1560



aggagttcta gtaaaactgg acgagatact ccagaaaatg gagaaactgc aattggtgct     1620



gaaaattcag aaaaaataga tgagaattca gataaagaga tggaagtaga agaatctcca     1680



gagaaaataa aagtacagac aacaccaaaa gtagaagaag aacaggattt gaaatttcag     1740



attggagaac tggcaaatac cctgacaagt aaattcgagt ttctaggcat taatagacaa     1800



tccatctcca actttcatgt gctgctctta cagactgaga ctcgaattgc agactggcgg     1860



gaaggggctc ttaatggaaa ctaccttaaa cgaaaacttc aggatgcagc agaacaacta     1920



aaacagtatg aaataaacgc cactcctaaa ggctggtcct gccactggga cagggatcat     1980



agacggtatt tctatgtaaa cgaacagtcg ggcgagtctc agtgggagtt tccagatggt     2040



gaagaggaag aagaagaaag ccaagcacaa gaaaatagag atgagactct tgccaaacag     2100



accttgaaag acaaaactgg cactgattca aattcaacag aatcctctga aacttccaca     2160



ggttctcttt gtaaagaatc cttttctggt caagtttctt cttcatcact catgccactt     2220



actccattct ggaccctcct tcagtcaaat gttcctgtgc ttcaacctcc attacccttg     2280



gaaatgccac cacccccacc tccacctcca gaatcacctc caccccctcc tccaccacct     2340



cctcctgcgg aagatggtga gatccaggag gtagagatgg aggatgaggg aagtgaggag     2400



ccccctgccc caggaacaga ggaagatacc cctttgaaac cttcagcaca aaccacagtt     2460



gtaactagcc agagttcagt tgattccacc atctctagtt cttcttccac taaaggaata     2520



aagaggaaag ctacagaaat tagcactgca gtggttcaga ggtcagctac cattggcagt     2580



tctccagttc tctatagcca gtcagctata gctacaggtc accaggcagc agggattgga     2640



aaccaggcaa caggaattgg acatcagaca ataccagtta gccttccagc agcaggaatg     2700



ggtcatcagg ccagaggaat gagcctgcag tcaaattacc ttggactagc ggcagcacct     2760



gcaattatga gttatgcaga atgttctgtc ccaattggag tgactgctcc ctcattgcag     2820



ccagttcagg cccgaggtgc tgtgcctacc gctaccatta tagaaccacc accaccacct     2880



cctcctcctc ctcctccacc accaccagct cccaaaatgc caccacctga aaagacaaaa     2940



aaaggaagga aagacaaggc aaagaagagt aagaccaaaa tgccatcttt ggtaaaaaag     3000



tggcagagta tccagcgtga gttagatgaa gaggacaatt ctagttccag tgaagaggat     3060



cgggaatcaa ctgcacagaa gcgaattgaa gagtggaaac agcagcagct ggttagtggc     3120



atggcagaga gaaatgctaa ttttgaagcc cttcctgagg attggagagc aaggctgaag     3180



agaaggaaaa tggctccaaa cacatagttt ttaagttttt aaaacttttt tgtattattg     3240



tttgttttgt gttcagttca aagtcttaac cagttttatt gtcaaataaa ctataaatgt     3300



tatgggggag atcttataaa tttcctgggc aagagtgtat gcatacaaag ttttcacttt     3360



tgtgaaatgt aatttttctg tttttgcaaa gggatgaggt gattggaatt gctttgacca     3420



tgctgccttt attctcaaac tggcaaactt agcatgttag gtgtattaac ctcatcagtc     3480



ttgaagaaca tgtggctcat gagtataaca cttctgtaga ggactccctg acaaaagtga     3540



agaattaact tctcctccag aacaagtgca attcagaagg cagctctgca ttctaccttg     3600



cttgactgga attgtctgaa gctttttctg gcctcttttc tctagtcggc cacccctgaa     3660



gtgctgaggt ctaagtggtt tacctcgtgc tgatagatgg ccacactctt tagagtagtt     3720



ctcataagtt ctagaactgg tagctcggtc gtttcgcaca ctaggtggca tacaggcagc     3780



agcaggtgtt catatccttg attttgagaa tttcccctca agtatgtggc agtaaataca     3840



acaagacact ctatgtatta atgtctccat tgtcttaacc ctgttccaaa acaaaattca     3900



cctcctttct ttatgtgaat gtattctcca taaaattcca gtatttaaaa agcagtttac     3960



tgttctgtac tttctgttgt atcacaatca ggtaaaagtc actttaaact gaggaaacgg     4020



caaattgtgt tttaaagctc tttgtatttc tccagtttct gaccttgtaa atttgtatat     4080



atgcactaat aaagcttttt ttataatcct gaaaaaaaaa aaaaaaa                   4127





<210>  111

<211>  1017

<212>  PRT

<213>  Homo sapiens



<400>  111



Met Gly Lys Lys Ser Arg Ala Val Pro Gly Arg Arg Pro Ile Leu Gln 

1               5                   10                  15      





Leu Ser Pro Pro Gly Pro Arg Gly Ser Thr Pro Gly Arg Asp Pro Glu 

            20                  25                  30          





Pro Glu Pro Asp Thr Glu Pro Asp Ser Thr Ala Ala Val Pro Ser Gln 

        35                  40                  45              





Pro Ala Pro Ser Ala Ala Thr Thr Thr Thr Thr Ala Val Thr Ala Ala 

    50                  55                  60                  





Ala Ala Ser Asp Asp Ser Pro Ser Glu Asp Glu Gln Glu Ala Val Gln 

65                  70                  75                  80  





Glu Val Pro Arg Val Val Gln Asn Pro Pro Lys Pro Val Met Thr Thr 

                85                  90                  95      





Arg Pro Thr Ala Val Lys Ala Thr Gly Gly Leu Cys Leu Leu Gly Ala 

            100                 105                 110         





Tyr Ala Asp Ser Asp Asp Asp Asp Asn Asp Val Ser Glu Lys Leu Ala 

        115                 120                 125             





Gln Ser Lys Glu Thr Asn Gly Asn Gln Ser Thr Asp Ile Asp Ser Thr 

    130                 135                 140                 





Leu Ala Asn Phe Leu Ala Glu Ile Asp Ala Ile Thr Ala Pro Gln Pro 

145                 150                 155                 160 





Ala Ala Pro Val Gly Ala Ser Ala Pro Pro Pro Thr Pro Pro Arg Pro 

                165                 170                 175     





Glu Pro Lys Glu Ala Ala Thr Ser Thr Leu Ser Ser Ser Thr Ser Asn 

            180                 185                 190         





Gly Thr Asp Ser Thr Gln Thr Ser Gly Trp Gln Tyr Asp Thr Gln Cys 

        195                 200                 205             





Ser Leu Ala Gly Val Gly Ile Glu Met Gly Asp Trp Gln Glu Val Trp 

    210                 215                 220                 





Asp Glu Asn Thr Gly Cys Tyr Tyr Tyr Trp Asn Thr Gln Thr Asn Glu 

225                 230                 235                 240 





Val Thr Trp Glu Leu Pro Gln Tyr Leu Ala Thr Gln Val Gln Gly Leu 

                245                 250                 255     





Gln His Tyr Gln Pro Ser Ser Val Pro Gly Ala Glu Thr Ser Phe Val 

            260                 265                 270         





Val Asn Thr Asp Ile Tyr Ser Lys Glu Lys Thr Ile Ser Val Ser Ser 

        275                 280                 285             





Ser Lys Ser Gly Pro Val Ile Ala Lys Arg Glu Val Lys Lys Glu Val 

    290                 295                 300                 





Asn Glu Gly Ile Gln Ala Leu Ser Asn Ser Glu Glu Glu Lys Lys Gly 

305                 310                 315                 320 





Val Ala Ala Ser Leu Leu Ala Pro Leu Leu Pro Glu Gly Ile Lys Glu 

                325                 330                 335     





Glu Glu Glu Arg Trp Arg Arg Lys Val Ile Cys Lys Glu Glu Pro Val 

            340                 345                 350         





Ser Glu Val Lys Glu Thr Ser Thr Thr Val Glu Glu Ala Thr Thr Ile 

        355                 360                 365             





Val Lys Pro Gln Glu Ile Met Leu Asp Asn Ile Glu Asp Pro Ser Gln 

    370                 375                 380                 





Glu Asp Leu Cys Ser Val Val Gln Ser Gly Glu Ser Glu Glu Glu Glu 

385                 390                 395                 400 





Glu Gln Asp Thr Leu Glu Leu Glu Leu Val Leu Glu Arg Lys Lys Ala 

                405                 410                 415     





Glu Leu Arg Ala Leu Glu Glu Gly Asp Gly Ser Val Ser Gly Ser Ser 

            420                 425                 430         





Pro Arg Ser Asp Ile Ser Gln Pro Ala Ser Gln Asp Gly Met Arg Arg 

        435                 440                 445             





Leu Met Ser Lys Arg Gly Lys Trp Lys Met Phe Val Arg Ala Thr Ser 

    450                 455                 460                 





Pro Glu Ser Thr Ser Arg Ser Ser Ser Lys Thr Gly Arg Asp Thr Pro 

465                 470                 475                 480 





Glu Asn Gly Glu Thr Ala Ile Gly Ala Glu Asn Ser Glu Lys Ile Asp 

                485                 490                 495     





Glu Asn Ser Asp Lys Glu Met Glu Val Glu Glu Ser Pro Glu Lys Ile 

            500                 505                 510         





Lys Val Gln Thr Thr Pro Lys Val Glu Glu Glu Gln Asp Leu Lys Phe 

        515                 520                 525             





Gln Ile Gly Glu Leu Ala Asn Thr Leu Thr Ser Lys Phe Glu Phe Leu 

    530                 535                 540                 





Gly Ile Asn Arg Gln Ser Ile Ser Asn Phe His Val Leu Leu Leu Gln 

545                 550                 555                 560 





Thr Glu Thr Arg Ile Ala Asp Trp Arg Glu Gly Ala Leu Asn Gly Asn 

                565                 570                 575     





Tyr Leu Lys Arg Lys Leu Gln Asp Ala Ala Glu Gln Leu Lys Gln Tyr 

            580                 585                 590         





Glu Ile Asn Ala Thr Pro Lys Gly Trp Ser Cys His Trp Asp Arg Asp 

        595                 600                 605             





His Arg Arg Tyr Phe Tyr Val Asn Glu Gln Ser Gly Glu Ser Gln Trp 

    610                 615                 620                 





Glu Phe Pro Asp Gly Glu Glu Glu Glu Glu Glu Ser Gln Ala Gln Glu 

625                 630                 635                 640 





Asn Arg Asp Glu Thr Leu Ala Lys Gln Thr Leu Lys Asp Lys Thr Gly 

                645                 650                 655     





Thr Asp Ser Asn Ser Thr Glu Ser Ser Glu Thr Ser Thr Gly Ser Leu 

            660                 665                 670         





Cys Lys Glu Ser Phe Ser Gly Gln Val Ser Ser Ser Ser Leu Met Pro 

        675                 680                 685             





Leu Thr Pro Phe Trp Thr Leu Leu Gln Ser Asn Val Pro Val Leu Gln 

    690                 695                 700                 





Pro Pro Leu Pro Leu Glu Met Pro Pro Pro Pro Pro Pro Pro Pro Glu 

705                 710                 715                 720 





Ser Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Asp Gly Glu 

                725                 730                 735     





Ile Gln Glu Val Glu Met Glu Asp Glu Gly Ser Glu Glu Pro Pro Ala 

            740                 745                 750         





Pro Gly Thr Glu Glu Asp Thr Pro Leu Lys Pro Ser Ala Gln Thr Thr 

        755                 760                 765             





Val Val Thr Ser Gln Ser Ser Val Asp Ser Thr Ile Ser Ser Ser Ser 

    770                 775                 780                 





Ser Thr Lys Gly Ile Lys Arg Lys Ala Thr Glu Ile Ser Thr Ala Val 

785                 790                 795                 800 





Val Gln Arg Ser Ala Thr Ile Gly Ser Ser Pro Val Leu Tyr Ser Gln 

                805                 810                 815     





Ser Ala Ile Ala Thr Gly His Gln Ala Ala Gly Ile Gly Asn Gln Ala 

            820                 825                 830         





Thr Gly Ile Gly His Gln Thr Ile Pro Val Ser Leu Pro Ala Ala Gly 

        835                 840                 845             





Met Gly His Gln Ala Arg Gly Met Ser Leu Gln Ser Asn Tyr Leu Gly 

    850                 855                 860                 





Leu Ala Ala Ala Pro Ala Ile Met Ser Tyr Ala Glu Cys Ser Val Pro 

865                 870                 875                 880 





Ile Gly Val Thr Ala Pro Ser Leu Gln Pro Val Gln Ala Arg Gly Ala 

                885                 890                 895     





Val Pro Thr Ala Thr Ile Ile Glu Pro Pro Pro Pro Pro Pro Pro Pro 

            900                 905                 910         





Pro Pro Pro Pro Pro Pro Ala Pro Lys Met Pro Pro Pro Glu Lys Thr 

        915                 920                 925             





Lys Lys Gly Arg Lys Asp Lys Ala Lys Lys Ser Lys Thr Lys Met Pro 

    930                 935                 940                 





Ser Leu Val Lys Lys Trp Gln Ser Ile Gln Arg Glu Leu Asp Glu Glu 

945                 950                 955                 960 





Asp Asn Ser Ser Ser Ser Glu Glu Asp Arg Glu Ser Thr Ala Gln Lys 

                965                 970                 975     





Arg Ile Glu Glu Trp Lys Gln Gln Gln Leu Val Ser Gly Met Ala Glu 

            980                 985                 990         





Arg Asn Ala Asn Phe Glu Ala Leu  Pro Glu Asp Trp Arg  Ala Arg Leu 

        995                 1000                 1005             





Lys Arg  Arg Lys Met Ala Pro  Asn Thr 

    1010                 1015         





<210>  112

<211>  1245

<212>  DNA

<213>  Homo sapiens



<400>  112

ataagagacc acaagcgacc cgcagggcca gacgttcttc gccgagagtc gtcggggttt       60



cctgcttcaa cagtgcttgg acggaacccg gcgctcgttc cccaccccgg ccggccgccc      120



atagccagcc ctccgtcacc tcttcaccgc accctcggac tgccccaagg cccccgccgc      180



cgctccagcg ccgcgcagcc accgccgccg ccgccgcctc tccttagtcg ccgccatgac      240



gaccgcgtcc acctcgcagg tgcgccagaa ctaccaccag gactcagagg ccgccatcaa      300



ccgccagatc aacctggagc tctacgcctc ctacgtttac ctgtccatgt cttactactt      360



tgaccgcgat gatgtggctt tgaagaactt tgccaaatac tttcttcacc aatctcatga      420



ggagagggaa catgctgaga aactgatgaa gctgcagaac caacgaggtg gccgaatctt      480



ccttcaggat atcaagaaac cagactgtga tgactgggag agcgggctga atgcaatgga      540



gtgtgcatta catttggaaa aaaatgtgaa tcagtcacta ctggaactgc acaaactggc      600



cactgacaaa aatgaccccc atttgtgtga cttcattgag acacattacc tgaatgagca      660



ggtgaaagcc atcaaagaat tgggtgacca cgtgaccaac ttgcgcaaga tgggagcgcc      720



cgaatctggc ttggcggaat atctctttga caagcacacc ctgggagaca gtgataatga      780



aagctaagcc tcgggctaat ttccccatag ccgtggggtg acttccctgg tcaccaaggc      840



agtgcatgca tgttggggtt tcctttacct tttctataag ttgtaccaaa acatccactt      900



aagttctttg atttgtacca ttccttcaaa taaagaaatt tggtacccag gtgttgtctt      960



tgaggtcttg ggatgaatca gaaatctatc caggctatct tccagattcc ttaagtgccg     1020



ttgttcagtt ctaatcacac taatcaaaaa gaaacgagta tttgtattta ttaaactcat     1080



tagtttgggc agtatactaa ggtgtggctg tcttggattc agatagaact aagggttccc     1140



gactctgaat ccagagtctg agttaaatgt ttccaatggt tcagtctagc tttcacagtt     1200



tttatgaata aaaggcatta aaggctgaaa aaaaaaaaaa aaaaa                     1245





<210>  113

<211>  183

<212>  PRT

<213>  Homo sapiens



<400>  113



Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 

1               5                   10                  15      





Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 

            20                  25                  30          





Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 

        35                  40                  45              





Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 

    50                  55                  60                  





Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 

65                  70                  75                  80  





Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 

                85                  90                  95      





Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 

            100                 105                 110         





Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 

        115                 120                 125             





His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 

    130                 135                 140                 





Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 

145                 150                 155                 160 





Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 

                165                 170                 175     





Gly Asp Ser Asp Asn Glu Ser 

            180             





<210>  114

<211>  6329

<212>  DNA

<213>  Homo sapiens



<400>  114

gattgggggc ggtggtctgg gtgtgattcc tgtgggggaa accagcccga ggtgccttgg       60



ctcaggcttg cctgcctgga gtccttgtcg tgtacccgtc tgtggcccta gagtcacctc      120



ctgctccttt tcactgggtt tctccccaga ccaagcccct ggatttgagc ttctgagcag      180



ccaactgatt tttttcatga gggaaagaat tttgctccta gatttatttc taatcctttt      240



ctccgtaact gaccttttct ctgtaagcta tttgtggctc tagtgggttt ttgtttgctt      300



gcttgttttt gttttatctt tgccctgaac gtccatcctg gcctcggctg cctccctccc      360



cgagttcttc actacacctc ctgtctcagc ctcccagaga gggtggcgag ggtgctgatg      420



cccagagaca ccatccggcg aatggacctc tcctgtcatg cggggcaggg cagggctgcc      480



ggcagagcca tgtcctgaac cctccctcct cccccctgct ctccttaagg gtctttccca      540



gatgtgaagg tccctcccag gctctactga ggtcagacca attcccagtg gcttgggtac      600



cctcgttcac tccagcacca gcccctgccc tccttcttcc cgggccaggc tgccaggtga      660



gccccgggcc aagggtggtt gccctgctga ggccgaaagg actcgagctt cccatctcct      720



cgcctccccc aggtctttca ccgtctggac tcatctctgg gtaactcatg gtgtgagtgg      780



ccacgtggct ggctcaggtg agtcctttta gaccccaggt gacccaccag ctagtccggg      840



gcccattgtt gtgcccacta ggatgtcccc catggtgtcc tccctgcgct ttaaagttct      900



ccttcgtgtg ctgttcttca tggcccctgt tcccccacag gtgtttggac agtgaacgcc      960



aggtcccctc ctccccaccc ccggcctctc aaacacgccc agccccacga tggcagcaga     1020



gacactcaac tttgggcctg agtggctcag ggccctgtcc gggggcggca gcgtggcctc     1080



cccacccccg tcccctgcca tgcccaaata caagctggct gactaccgtt atgggcgaga     1140



ggaaatgctg gctctctacg tcaaggagaa caaggtcccg gaagagctgc aggacaagga     1200



gttcgccgcg gtgctgcagg acgagccact gcagcccctg gctctggagc cgctgactga     1260



ggaggaacag agaaacttct ccctgtcagt gaacagcgtg gctgtgctga ggctgatggg     1320



gaaaggggct ggcccccccc tggctggcac ctcccgaggc aggggcagca cgcggagccg     1380



aggccgcggc cgtggtgaca gctgctttta ccaaagaagc atcgaagaag gcgatggggc     1440



ctttggacga agcccccggg aaatccagcg cagccagagc tgggatgaca gaggcgagag     1500



gcggtttgag aagtcagcaa ggcgggatgg agcacgatgt ggctttgagg agggaggggc     1560



tggcccaagg aaggagcacg cccgctcaga cagcgagaac tggcgctccc tacgggagga     1620



acaggaggag gaggaggagg gcagctggag gctcggagca gggccccggc gagacggcga     1680



ccgctggcgc tccgccagcc ctgatggtgg tccccgctct gctggctggc gggaacatgg     1740



ggaacggcgg cgcaagtttg aatttgattt gcgaggggat cgaggagggt gtggtgaaga     1800



ggaggggcgg ggagggggag gcagctctca cctgcggcgg tgccgagcgc ctgaaggctt     1860



tgaggaggac aaggatgggc tcccagagtg gtgcctggac gatgaggatg aagaaatggg     1920



cacctttgat gcctctgggg ccttcttgcc tctcaagaag ggccccaagg agcccattcc     1980



tgaggagcag gagctggact tccaagggtt ggaggaggag gaggaacctt ccgaagggct     2040



agaggaggaa gggcctgagg caggtgggaa agagctgacc ccactgcctc ctcaggagga     2100



gaagtccagc tccccatccc cactgcccac cctgggccca ctctggggga caaacgggga     2160



tggggacgaa actgcagaga aagagccccc agcggccgaa gatgatattc gggggatcca     2220



gctgagtccc ggggtgggct cctctgctgg cccacccgga gatctggagg atgatgaagg     2280



cttgaagcac ctgcagcagg aggcggagaa gctggtggcc tccctgcagg acagctcctt     2340



ggaggaggag cagttcacgg ctgccatgca gacccagggc ctgcgccact ctgcagccgc     2400



cactgccctc ccgctcagcc atggggctgc ccggaagtgg ttctacaagg acccacaggg     2460



cgagatccaa ggccccttca cgacacagga gatggcagag tggttccagg ccggctactt     2520



ttccatgtca ctgctggtga agcggggctg cgatgagggc ttccagccgc tgggcgaggt     2580



gatcaagatg tggggccgcg tgccctttgc cccagggccc tcacctcccc cactgctggg     2640



aaacatggac caggagcggc tgaagaagca acaggagctg gccgcggcgg ccttgtacca     2700



gcagctgcag caccagcagt ttctccagct ggtcagcagc cgccagctcc cacagtgcgc     2760



gctccgagaa aaggcagctc tgggggacct gacaccgcca ccaccgccgc cgccacagca     2820



gcagcagcag cagctcacgg cattcctgca gcagctccag gcgctcaaac cccccagagg     2880



cggggaccag aacctgctcc cgacgatgag ccggtccttg tcggtgccag attcgggccg     2940



cctctgggac gtacatacct cagcctcatc acagtcaggt ggtgaggcca gtctttggga     3000



cataccaatt aactcttcga ctcagggtcc aattctagaa caactccagc tgcaacataa     3060



attccaggag cgcagagaag tggagctcag ggcgaagcgg gaggaagagg aacgcaagcg     3120



tcgagaggag aagcgccgcc agcagcagca ggaggagcag aagcggcggc aggaggagga     3180



agagctgttt cggcgcaagc acgtgcggca gcaggagcta ttgctgaagt tgctacagca     3240



gcagcaggcg gtccctgtgc cccccgcacc cagctccccg cccccactct gggctggcct     3300



ggccaagcag gggctgtcca tgaagacgct cctggagttg cagctggagg gcgagcggca     3360



gctgcacaaa cagcccccac ctcgggagcc agctcgggcc caggccccca accaccgagt     3420



gcagcttggg ggcctgggca ctgcccccct gaaccagtgg gtgtctgagg ctgggccact     3480



gtggggcggg ccagacaaga gtgggggcgg cagcagcggc ctggggctct gggaggacac     3540



ccccaagagc ggcgggagcc tggtccgtgg cctcggcctg aagaacagcc ggagcagccc     3600



atctctcagt gactcataca gccacctatc gggtcggccc attcgcaaaa agacggagga     3660



agaagagaag ctgctgaagc tgctgcaggg cattcccagg ccccaggacg gcttcaccca     3720



gtggtgcgag cagatgctgc acacgctgag cgccacgggc agcctggacg tgcccatggc     3780



tgtagcgatc ctcaaggagg tggaatcccc ctatgatgtc cacgattata tccgttcctg     3840



cctgggggac acgctggaag ccaaagaatt tgccaaacaa ttcctggagc ggagggccaa     3900



gcagaaagcc agccagcagc ggcagcagca gcaggaggca tggctgagca gcgcctcgct     3960



gcagacggcc ttccaggcca accacagcac caaactcggc cccggggagg gcagcaaggc     4020



caagaggcgg gcactgatgc tgcactcaga ccccagcatc ctggggtact ccctgcacgg     4080



atcttctggt gagatcgaga gcgtggatga ctactgacca gcccggaccc ccagcccctg     4140



ggctgtaggc cagggcagcc acagcggcgt ggaccgaggg tcccagcctg caggctcccc     4200



gcagagagca caggaagagg caggggcggg gtccccagca cttgttacaa acacacgatg     4260



caccttaact cacccaccac gaggcacttt acagactggg ggagggggtt tttcttttta     4320



tttttttttt taattttaaa cgactgaaga aaacattagg agaggcaaaa atattgttaa     4380



aaactagact ctaaacaccc cttcctgctg tgaggatagt gggtgtgaca atggaaggtc     4440



cacagaggtt tttgtttttt ggtttttttt ttttttttaa gaaaaaaaga tgaaaaatga     4500



aaaaaaaaat ggttaggagg ctgaaagaaa aaacacactg ttattttggg gcagtgggga     4560



cacaggcccc gtggacctgt cctgcctggc ccccaaggcc atacttaccc cccagaaggc     4620



gggccatggg gtaactggaa gctgggggcc agcagtttgc acaggaggcc tgtctgagcc     4680



ccacccgcca gacctgttgt gagcagctcc tgtcactgag gctggctgag gtgtccgggg     4740



tggggccaaa gtagcccctt ggcttcgctg ctttggggga cagttgcaca aattggacga     4800



gtggccccag ctctctggct gccatcttgt gctggccgag tagacgggag gggccaagcc     4860



gtgccaacct ctctggctgg cagggtgggg cagcaggact ctggttctgg tgaggggcgt     4920



ctcccactgc tgccattttg ggggacaccc tgggtttgaa cctgaaagcc ccagctctct     4980



gccttgccac gtgaatgtat tctttgggcc acaagccccc gcctcacccc tgcctgagct     5040



gcctcacccc tgtgagcggc gggggtggat gattgctcca gaggctgcag agagaaggct     5100



gagctgtttc tccagtgaag ggggcaggag gaggggcctc aaaggcaagg agtgggtggc     5160



tttgggctta gggttgcagt agaggggctg ccgcccgggg ccccaacctg tagccagctc     5220



gtaagatgtg gaccacccag ctctgcacct gacccttccg ctgaccaaat gggagaggag     5280



caggtggcct tccgggtctg atatgatgcg ctttttaccg ttgggtaagg ttggggtgaa     5340



gagaagtgtg cggctcctgg gtcagaggag gctgcccctt ctattgctca cccacttctt     5400



attcccggtc ccctacttgg gttcgtctcc gcccattttg ggttttgtaa cagttttgtc     5460



ttttgggttt ctcatccagc tcctcccatt gacctcattg ctcagagtgc agtattaggg     5520



caaggcttcg ccactgcctc cctccatgaa tgtatttctc cctcctgccc tggggacatg     5580



gggagtggcc cgtttctttc cccatctagt cccagaaaga tggtgtttgg ttttctgttg     5640



ttggattttt tttttttttt tttttttttt gcaccaaagt ggcaactagg tcagtgttgg     5700



gggatcaagc tggcctcggg gtggggggcc cccacctgcc tctccctggt tcccacagtg     5760



ttagcgtccc tgaaaagaca atattctctc taaagcaata aggggtgacg ggccgggggg     5820



agtgtttgct gctgctggcc cccagctccc cttccctctt gccaggtgtg ggggagactc     5880



ctgttgtgac tgaatgtaac ccccccaccc ctgccgcagc caatgcaggg gaagggggac     5940



actcttcctg tctcttctcc ccagctaaag agactttgga cttagggggc ccatgagcct     6000



ggagaggcct taaccctgtg aggaagtata gggggagccc tctcccaccc ccatcccctt     6060



ctgagagtgg tcaatgttta caagcccctg agcccccctg cccagggact cagaccctgt     6120



tgctgtcctt ccccggcccc ggtcttcctg ggccctcgct gctcccctgc ccttcctggg     6180



gttggggtgg gtgcaggggt caccgtgttc cctgtctgcc ttgtacccac agtctccccg     6240



ccccctctcc accctgtgtg acttccctct cttttacctg ctcctgtaaa tactcccttc     6300



tcccaataaa acttggtgtg tgttctccc                                       6329





<210>  115

<211>  1035

<212>  PRT

<213>  Homo sapiens



<400>  115



Met Ala Ala Glu Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg Ala Leu 

1               5                   10                  15      





Ser Gly Gly Gly Ser Val Ala Ser Pro Pro Pro Ser Pro Ala Met Pro 

            20                  25                  30          





Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met Leu Ala 

        35                  40                  45              





Leu Tyr Val Lys Glu Asn Lys Val Pro Glu Glu Leu Gln Asp Lys Glu 

    50                  55                  60                  





Phe Ala Ala Val Leu Gln Asp Glu Pro Leu Gln Pro Leu Ala Leu Glu 

65                  70                  75                  80  





Pro Leu Thr Glu Glu Glu Gln Arg Asn Phe Ser Leu Ser Val Asn Ser 

                85                  90                  95      





Val Ala Val Leu Arg Leu Met Gly Lys Gly Ala Gly Pro Pro Leu Ala 

            100                 105                 110         





Gly Thr Ser Arg Gly Arg Gly Ser Thr Arg Ser Arg Gly Arg Gly Arg 

        115                 120                 125             





Gly Asp Ser Cys Phe Tyr Gln Arg Ser Ile Glu Glu Gly Asp Gly Ala 

    130                 135                 140                 





Phe Gly Arg Ser Pro Arg Glu Ile Gln Arg Ser Gln Ser Trp Asp Asp 

145                 150                 155                 160 





Arg Gly Glu Arg Arg Phe Glu Lys Ser Ala Arg Arg Asp Gly Ala Arg 

                165                 170                 175     





Cys Gly Phe Glu Glu Gly Gly Ala Gly Pro Arg Lys Glu His Ala Arg 

            180                 185                 190         





Ser Asp Ser Glu Asn Trp Arg Ser Leu Arg Glu Glu Gln Glu Glu Glu 

        195                 200                 205             





Glu Glu Gly Ser Trp Arg Leu Gly Ala Gly Pro Arg Arg Asp Gly Asp 

    210                 215                 220                 





Arg Trp Arg Ser Ala Ser Pro Asp Gly Gly Pro Arg Ser Ala Gly Trp 

225                 230                 235                 240 





Arg Glu His Gly Glu Arg Arg Arg Lys Phe Glu Phe Asp Leu Arg Gly 

                245                 250                 255     





Asp Arg Gly Gly Cys Gly Glu Glu Glu Gly Arg Gly Gly Gly Gly Ser 

            260                 265                 270         





Ser His Leu Arg Arg Cys Arg Ala Pro Glu Gly Phe Glu Glu Asp Lys 

        275                 280                 285             





Asp Gly Leu Pro Glu Trp Cys Leu Asp Asp Glu Asp Glu Glu Met Gly 

    290                 295                 300                 





Thr Phe Asp Ala Ser Gly Ala Phe Leu Pro Leu Lys Lys Gly Pro Lys 

305                 310                 315                 320 





Glu Pro Ile Pro Glu Glu Gln Glu Leu Asp Phe Gln Gly Leu Glu Glu 

                325                 330                 335     





Glu Glu Glu Pro Ser Glu Gly Leu Glu Glu Glu Gly Pro Glu Ala Gly 

            340                 345                 350         





Gly Lys Glu Leu Thr Pro Leu Pro Pro Gln Glu Glu Lys Ser Ser Ser 

        355                 360                 365             





Pro Ser Pro Leu Pro Thr Leu Gly Pro Leu Trp Gly Thr Asn Gly Asp 

    370                 375                 380                 





Gly Asp Glu Thr Ala Glu Lys Glu Pro Pro Ala Ala Glu Asp Asp Ile 

385                 390                 395                 400 





Arg Gly Ile Gln Leu Ser Pro Gly Val Gly Ser Ser Ala Gly Pro Pro 

                405                 410                 415     





Gly Asp Leu Glu Asp Asp Glu Gly Leu Lys His Leu Gln Gln Glu Ala 

            420                 425                 430         





Glu Lys Leu Val Ala Ser Leu Gln Asp Ser Ser Leu Glu Glu Glu Gln 

        435                 440                 445             





Phe Thr Ala Ala Met Gln Thr Gln Gly Leu Arg His Ser Ala Ala Ala 

    450                 455                 460                 





Thr Ala Leu Pro Leu Ser His Gly Ala Ala Arg Lys Trp Phe Tyr Lys 

465                 470                 475                 480 





Asp Pro Gln Gly Glu Ile Gln Gly Pro Phe Thr Thr Gln Glu Met Ala 

                485                 490                 495     





Glu Trp Phe Gln Ala Gly Tyr Phe Ser Met Ser Leu Leu Val Lys Arg 

            500                 505                 510         





Gly Cys Asp Glu Gly Phe Gln Pro Leu Gly Glu Val Ile Lys Met Trp 

        515                 520                 525             





Gly Arg Val Pro Phe Ala Pro Gly Pro Ser Pro Pro Pro Leu Leu Gly 

    530                 535                 540                 





Asn Met Asp Gln Glu Arg Leu Lys Lys Gln Gln Glu Leu Ala Ala Ala 

545                 550                 555                 560 





Ala Leu Tyr Gln Gln Leu Gln His Gln Gln Phe Leu Gln Leu Val Ser 

                565                 570                 575     





Ser Arg Gln Leu Pro Gln Cys Ala Leu Arg Glu Lys Ala Ala Leu Gly 

            580                 585                 590         





Asp Leu Thr Pro Pro Pro Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 

        595                 600                 605             





Leu Thr Ala Phe Leu Gln Gln Leu Gln Ala Leu Lys Pro Pro Arg Gly 

    610                 615                 620                 





Gly Asp Gln Asn Leu Leu Pro Thr Met Ser Arg Ser Leu Ser Val Pro 

625                 630                 635                 640 





Asp Ser Gly Arg Leu Trp Asp Val His Thr Ser Ala Ser Ser Gln Ser 

                645                 650                 655     





Gly Gly Glu Ala Ser Leu Trp Asp Ile Pro Ile Asn Ser Ser Thr Gln 

            660                 665                 670         





Gly Pro Ile Leu Glu Gln Leu Gln Leu Gln His Lys Phe Gln Glu Arg 

        675                 680                 685             





Arg Glu Val Glu Leu Arg Ala Lys Arg Glu Glu Glu Glu Arg Lys Arg 

    690                 695                 700                 





Arg Glu Glu Lys Arg Arg Gln Gln Gln Gln Glu Glu Gln Lys Arg Arg 

705                 710                 715                 720 





Gln Glu Glu Glu Glu Leu Phe Arg Arg Lys His Val Arg Gln Gln Glu 

                725                 730                 735     





Leu Leu Leu Lys Leu Leu Gln Gln Gln Gln Ala Val Pro Val Pro Pro 

            740                 745                 750         





Ala Pro Ser Ser Pro Pro Pro Leu Trp Ala Gly Leu Ala Lys Gln Gly 

        755                 760                 765             





Leu Ser Met Lys Thr Leu Leu Glu Leu Gln Leu Glu Gly Glu Arg Gln 

    770                 775                 780                 





Leu His Lys Gln Pro Pro Pro Arg Glu Pro Ala Arg Ala Gln Ala Pro 

785                 790                 795                 800 





Asn His Arg Val Gln Leu Gly Gly Leu Gly Thr Ala Pro Leu Asn Gln 

                805                 810                 815     





Trp Val Ser Glu Ala Gly Pro Leu Trp Gly Gly Pro Asp Lys Ser Gly 

            820                 825                 830         





Gly Gly Ser Ser Gly Leu Gly Leu Trp Glu Asp Thr Pro Lys Ser Gly 

        835                 840                 845             





Gly Ser Leu Val Arg Gly Leu Gly Leu Lys Asn Ser Arg Ser Ser Pro 

    850                 855                 860                 





Ser Leu Ser Asp Ser Tyr Ser His Leu Ser Gly Arg Pro Ile Arg Lys 

865                 870                 875                 880 





Lys Thr Glu Glu Glu Glu Lys Leu Leu Lys Leu Leu Gln Gly Ile Pro 

                885                 890                 895     





Arg Pro Gln Asp Gly Phe Thr Gln Trp Cys Glu Gln Met Leu His Thr 

            900                 905                 910         





Leu Ser Ala Thr Gly Ser Leu Asp Val Pro Met Ala Val Ala Ile Leu 

        915                 920                 925             





Lys Glu Val Glu Ser Pro Tyr Asp Val His Asp Tyr Ile Arg Ser Cys 

    930                 935                 940                 





Leu Gly Asp Thr Leu Glu Ala Lys Glu Phe Ala Lys Gln Phe Leu Glu 

945                 950                 955                 960 





Arg Arg Ala Lys Gln Lys Ala Ser Gln Gln Arg Gln Gln Gln Gln Glu 

                965                 970                 975     





Ala Trp Leu Ser Ser Ala Ser Leu Gln Thr Ala Phe Gln Ala Asn His 

            980                 985                 990         





Ser Thr Lys Leu Gly Pro Gly Glu  Gly Ser Lys Ala Lys  Arg Arg Ala 

        995                 1000                 1005             





Leu Met  Leu His Ser Asp Pro  Ser Ile Leu Gly Tyr  Ser Leu His 

    1010                 1015                 1020             





Gly Ser  Ser Gly Glu Ile Glu  Ser Val Asp Asp Tyr  

    1025                 1030                 1035 





<210>  116

<211>  1083

<212>  DNA

<213>  Homo sapiens



<400>  116

atggacccag aagaaacttc agtttatttg gattattact atgctacgag cccaaactct       60



gacatcaggg agacccactc ccatgttcct tacacctctg tcttccttcc agtcttttac      120



acagctgtgt tcctgactgg agtgctgggg aaccttgttc tcatgggagc gttgcatttc      180



aaacccggca gccgaagact gatcgacatc tttatcatca atctggctgc ctctgacttc      240



atttttcttg tcacattgcc tctctgggtg gataaagaag catctctagg actgtggagg      300



acgggctcct tcctgtgcaa agggagctcc tacatgatct ccgtcaatat gcactgcagt      360



gtcctcctgc tcacttgcat gagtgttgac cgctacctgg ccattgtgtg gccagtcgta      420



tccaggaaat tcagaaggac agactgtgca tatgtagtct gtgccagcat ctggtttatc      480



tcctgcctgc tggggttgcc tactcttctg tccagggagc tcacgctgat tgatgataag      540



ccatactgtg cagagaaaaa ggcaactcca attaaactca tatggtccct ggtggcctta      600



attttcacct tttttgtccc tttgttgagc attgtgacct gctactgttg cattgcaagg      660



aagctgtgtg cccattacca gcaatcagga aagcacaaca aaaagctgaa gaaatctata      720



aagatcatct ttattgtcgt ggcagccttt cttgtctcct ggctgccctt caatactttc      780



aagttcctgg ccattgtctc tgggttgcgg caagaacact atttaccctc agctattctt      840



cagcttggta tggaggtgag tggacccttg gcatttgcca acagctgtgt caaccctttc      900



atttactata tcttcgacag ctacatccgc cgggccattg tccactgctt gtgcccttgc      960



ctgaaaaact atgactttgg gagtagcact gagacatcag atagtcacct cactaaggct     1020



ctctccacct tcattcatgc agaagatttt gccaggagga ggaagaggtc tgtgtcactc     1080



taa                                                                   1083





<210>  117

<211>  360

<212>  PRT

<213>  Homo sapiens



<400>  117



Met Asp Pro Glu Glu Thr Ser Val Tyr Leu Asp Tyr Tyr Tyr Ala Thr 

1               5                   10                  15      





Ser Pro Asn Ser Asp Ile Arg Glu Thr His Ser His Val Pro Tyr Thr 

            20                  25                  30          





Ser Val Phe Leu Pro Val Phe Tyr Thr Ala Val Phe Leu Thr Gly Val 

        35                  40                  45              





Leu Gly Asn Leu Val Leu Met Gly Ala Leu His Phe Lys Pro Gly Ser 

    50                  55                  60                  





Arg Arg Leu Ile Asp Ile Phe Ile Ile Asn Leu Ala Ala Ser Asp Phe 

65                  70                  75                  80  





Ile Phe Leu Val Thr Leu Pro Leu Trp Val Asp Lys Glu Ala Ser Leu 

                85                  90                  95      





Gly Leu Trp Arg Thr Gly Ser Phe Leu Cys Lys Gly Ser Ser Tyr Met 

            100                 105                 110         





Ile Ser Val Asn Met His Cys Ser Val Leu Leu Leu Thr Cys Met Ser 

        115                 120                 125             





Val Asp Arg Tyr Leu Ala Ile Val Trp Pro Val Val Ser Arg Lys Phe 

    130                 135                 140                 





Arg Arg Thr Asp Cys Ala Tyr Val Val Cys Ala Ser Ile Trp Phe Ile 

145                 150                 155                 160 





Ser Cys Leu Leu Gly Leu Pro Thr Leu Leu Ser Arg Glu Leu Thr Leu 

                165                 170                 175     





Ile Asp Asp Lys Pro Tyr Cys Ala Glu Lys Lys Ala Thr Pro Ile Lys 

            180                 185                 190         





Leu Ile Trp Ser Leu Val Ala Leu Ile Phe Thr Phe Phe Val Pro Leu 

        195                 200                 205             





Leu Ser Ile Val Thr Cys Tyr Cys Cys Ile Ala Arg Lys Leu Cys Ala 

    210                 215                 220                 





His Tyr Gln Gln Ser Gly Lys His Asn Lys Lys Leu Lys Lys Ser Ile 

225                 230                 235                 240 





Lys Ile Ile Phe Ile Val Val Ala Ala Phe Leu Val Ser Trp Leu Pro 

                245                 250                 255     





Phe Asn Thr Phe Lys Phe Leu Ala Ile Val Ser Gly Leu Arg Gln Glu 

            260                 265                 270         





His Tyr Leu Pro Ser Ala Ile Leu Gln Leu Gly Met Glu Val Ser Gly 

        275                 280                 285             





Pro Leu Ala Phe Ala Asn Ser Cys Val Asn Pro Phe Ile Tyr Tyr Ile 

    290                 295                 300                 





Phe Asp Ser Tyr Ile Arg Arg Ala Ile Val His Cys Leu Cys Pro Cys 

305                 310                 315                 320 





Leu Lys Asn Tyr Asp Phe Gly Ser Ser Thr Glu Thr Ser Asp Ser His 

                325                 330                 335     





Leu Thr Lys Ala Leu Ser Thr Phe Ile His Ala Glu Asp Phe Ala Arg 

            340                 345                 350         





Arg Arg Lys Arg Ser Val Ser Leu 

        355                 360 





<210>  118

<211>  4507

<212>  DNA

<213>  Homo sapiens



<400>  118

ttccggccag cccctccccc gcctccctcg cgtggccacc tccccctctg ccttctccta       60



cccagtctct tccccaactc tccccacccc tggtgctctc cgccccgctt gcctcccgtt      120



cttccccgcc cgctccatcc gggtcgctga cggctgtctc tggactggac agcagtggcg      180



tccgcttttc tctaaggaac ccgataagaa ctccattttc tgttgatgtg gagacatagg      240



gtacctccaa ctttccgggg tttcagaaga gaatttttta ttgaaactgg aagaccaaaa      300



taattacaag catgttgtgc tggggaaatg catcctttgg gcagctaggt ttgggtggaa      360



ttgatgaaga aattgtacta gagcccagaa aaagtgactt ctttataaat aaaagggtcc      420



gagatgtagg atgtggactc agacatactg tgtttgttct ggatgatgga acagtgtaca      480



catgtggatg taatgatcta ggacagctag gtcatgaaaa atccagaaag aaaccagagc      540



aggttgttgc cctggatgcc caaaatattg tagctgtttc atgtggagaa gctcatacgt      600



tagcgctaaa tgacaaaggc caggtgtatg cttggggtct cgattctgat ggacagcttg      660



gcctggtagg atcagaggaa tgcatcagag tacccagaaa tattaaaagt ttgtcagata      720



tccagattgt acaggttgct tgtggttact atcattcact tgcactttct aaagcaagtg      780



aagtcttctg ttggggacag aataaatatg gccaattggg tttaggtact gactgtaaaa      840



agcaaacttc accgcagctg cttaagtctt tgcttggaat ccctttcatg caagttgcag      900



caggaggagc ccatagtttt gtactcaccc tttctggagc tatctttgga tggggacgca      960



acaagtttgg tcagctaggt cttaatgatg aaaatgatag gtatgttcct aatttactaa     1020



agtcactaag atctcagaaa atagtttata tttgttgtgg agaagatcat actgctgctc     1080



taaccaagga aggtggagtg tttacttttg gagctggagg gtatggtcag ttgggccata     1140



attctaccag tcatgaaata aacccaagga aagtttttga acttatggga agcattgtca     1200



ctgagattgc ttgtggacgg cagcacactt ctgcttttgt tccttcatca ggacgaattt     1260



actcttttgg gcttggtggt aatgggcagc tgggaaccgg ttcaacaagc aacaggaaaa     1320



gcccctttac tgtaaaagga aattggtacc cctataatgg gcagtgtcta ccagatattg     1380



attctgaaga atatttctgt gtaaaaagaa ttttctcagg gggagatcaa agcttttcac     1440



attactctag tccccagaac tgtgggccac cagatgactt cagatgtccc aatccgacaa     1500



agcagatctg gacagtgaat gaagctctaa ttcagaaatg gctgagctat ccttctggaa     1560



ggtttcctgt ggagatagcc aatgagatag atggaacgtt ttcttcctct ggttgcctaa     1620



atggaagttt tttagctgtt agcaatgatg atcactatag aacaggtacc agattttcag     1680



gggttgatat gaatgctgct aggcttttat tccacaaact tatacaacct gatcatccgc     1740



agatatctca gcaggtggca gctagtttgg aaaagaatct tattcctaaa ctgactagct     1800



ccttacctga tgttgaagca ttgaggtttt atcttactct accagaatgt cccctgatga     1860



gtgattccaa caatttcaca acaatagcaa ttccctttgg tacagctctt gtgaacctag     1920



aaaaggcacc actgaaagta cttgaaaact ggtggtcagt acttgaacct ccactattcc     1980



tcaagatagt agaacttttt aaggaagttg tggtacatct tttgaaactc tacaagatcg     2040



gtattccccc ttctgaaaga agaattttca acagttttct tcatactgca ttaaaggttt     2100



tagaaatact acatagggta aatgagaaaa tgggacagat tatacagtat gataaatttt     2160



atatacatga agtacaagaa ttgatagaca taagaaatga ttatatcaac tgggtccaac     2220



agcaggccta tggaatgttg gcagatatcc ctgttacaat ctgtacatat ccatttgtat     2280



ttgatgccca agcaaaaact actctgttac agaccgatgc agtcttacag atgcagatgg     2340



ctattgatca ggcccacagg cagaatgtct cctctctttt tctcccagtg attgaatctg     2400



tgaatccctg cttaattcta gtggtgcgta gagaaaatat tgtaggagat gcaatggaag     2460



tccttaggaa aacaaagaac atagattaca agaagccact caaggttata tttgttggag     2520



aagatgctgt ggatgcagga ggggtgcgca aagaattttt cttgctcatc atgagggaat     2580



tattggatcc taaatacggc atgtttaggt attatgaaga ttccaggctc atttggtttt     2640



ctgataagac atttgaagac agtgatttgt tccatttgat tggtgttatc tgtggcttag     2700



caatttataa ttgtaccatt gtggacctcc attttccttt ggctttatat aagaaactac     2760



tgaaaaagaa gccatccttg gatgatttga aagaactaat gcctgatgtt gggagaagca     2820



tgcaacagtt actggattat ccagaagatg acatagagga aacattttgt cttaatttta     2880



cgatcacagt tgaaaacttt ggtgcaacag aagtgaaaga gctggttcta aatggtgcag     2940



acacagctgt taacaaacaa aatcggcaag agtttgtcga tgcttatgtg gattacatat     3000



tcaataaatc agtggcttcc ttatttgatg cttttcatgc gggctttcat aaggtctgtg     3060



gaggaaaagt ccttctgctc tttcagccta atgaactaca agcaatggtc attggaaata     3120



caaattatga ttggaaggaa ctggaaaaga atacagaata caaaggggaa tattgggcag     3180



aacatcctac gataaaaatt ttttgggaag tatttcacga attaccattg gaaaagaaga     3240



aacagtttct gttatttttg acaggtagtg atcgcattcc tattcttggt atgaagagtc     3300



tgaaactagt catccagtcc acaggaggtg gtgaggagta tctcccagtt tcccatactt     3360



gttttaatct tctggatctt ccaaaatata cagaaaaaga aactctacgc tctaaactga     3420



tccaagctat tgatcacaat gaaggcttca gtttaatata actttggagt tataactatt     3480



cagtttagtg caaaagcatt aaactatttg tgtttttctt gtggtgatga attcagcaag     3540



gtgacagagg tactattata attcttactt gcagaatgtt caatctacga gtgttcatgg     3600



aagccaaaaa atattaaagg aaaatgaaca aactgttaat attattgtac agaaccatgg     3660



attttttttg accatcttct aataaacata gcaagtatta tgaatacatt aaagttttac     3720



taacatgaat tttaagagtt tgcatatttc agaaatgatc tggtgtgagt gcatggaaat     3780



attgcttaat ttttcttcaa tcattgagtg aaaaaccttt aactttggcc tgcaatagtc     3840



atttgattat tttttcattt tgtaaataat gttaagtttt gtaataaaat agttatgttc     3900



tgataccagt acagtttcta tggttgtaat tgaacttgaa cagactttta aaggttaaaa     3960



attatgattt aaatcttact ctgagactct ataaaaagaa aaaaaaggta gcatggtgga     4020



aacactatct tttctttttt gctagaataa gtgtctttgt gcaaacctaa atcacagata     4080



gggaatatac tacataacct gcagttcttt tctttgtgaa tcctgacaca ctgatagatg     4140



ggggattgtc gatcagagaa cttattaata tttagtactg gaagaactct gtctccacag     4200



ttgccagtaa taaaaagaaa cattggctac tatgagcacc aatcactggg ttatagcttt     4260



caaaattatt gatgctgcag tgctttagag ctatttcctt gaatttaaga aacaaatctt     4320



aacagtttta tggtgctgat gcttagttgt ctcatgccat taaattgtaa aagtgagttg     4380



atgcaataca tgtgactttc tgctataatg caaatattta ttttttaaat ttattttaaa     4440



atgccgtgaa aactgtttaa taaagattta ttgttttaat atttaaactt tcaaaaaaaa     4500



aaaaaaa                                                               4507





<210>  119

<211>  1049

<212>  PRT

<213>  Homo sapiens



<400>  119



Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 

1               5                   10                  15      





Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 

            20                  25                  30          





Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 

        35                  40                  45              





Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 

    50                  55                  60                  





Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 

65                  70                  75                  80  





Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 

                85                  90                  95      





Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 

            100                 105                 110         





Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 

        115                 120                 125             





Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 

    130                 135                 140                 





Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 

145                 150                 155                 160 





Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 

                165                 170                 175     





Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 

            180                 185                 190         





Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 

        195                 200                 205             





Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 

    210                 215                 220                 





Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 

225                 230                 235                 240 





Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 

                245                 250                 255     





Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 

            260                 265                 270         





Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 

        275                 280                 285             





Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 

    290                 295                 300                 





His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 

305                 310                 315                 320 





Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 

                325                 330                 335     





Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 

            340                 345                 350         





Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 

        355                 360                 365             





Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 

    370                 375                 380                 





Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 

385                 390                 395                 400 





Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 

                405                 410                 415     





Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 

            420                 425                 430         





Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 

        435                 440                 445             





Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 

    450                 455                 460                 





Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 

465                 470                 475                 480 





Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 

                485                 490                 495     





Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 

            500                 505                 510         





Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 

        515                 520                 525             





Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 

    530                 535                 540                 





Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 

545                 550                 555                 560 





Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 

                565                 570                 575     





Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 

            580                 585                 590         





Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 

        595                 600                 605             





Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 

    610                 615                 620                 





Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 

625                 630                 635                 640 





Gly Met Leu Ala Asp Ile Pro Val Thr Ile Cys Thr Tyr Pro Phe Val 

                645                 650                 655     





Phe Asp Ala Gln Ala Lys Thr Thr Leu Leu Gln Thr Asp Ala Val Leu 

            660                 665                 670         





Gln Met Gln Met Ala Ile Asp Gln Ala His Arg Gln Asn Val Ser Ser 

        675                 680                 685             





Leu Phe Leu Pro Val Ile Glu Ser Val Asn Pro Cys Leu Ile Leu Val 

    690                 695                 700                 





Val Arg Arg Glu Asn Ile Val Gly Asp Ala Met Glu Val Leu Arg Lys 

705                 710                 715                 720 





Thr Lys Asn Ile Asp Tyr Lys Lys Pro Leu Lys Val Ile Phe Val Gly 

                725                 730                 735     





Glu Asp Ala Val Asp Ala Gly Gly Val Arg Lys Glu Phe Phe Leu Leu 

            740                 745                 750         





Ile Met Arg Glu Leu Leu Asp Pro Lys Tyr Gly Met Phe Arg Tyr Tyr 

        755                 760                 765             





Glu Asp Ser Arg Leu Ile Trp Phe Ser Asp Lys Thr Phe Glu Asp Ser 

    770                 775                 780                 





Asp Leu Phe His Leu Ile Gly Val Ile Cys Gly Leu Ala Ile Tyr Asn 

785                 790                 795                 800 





Cys Thr Ile Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys Leu 

                805                 810                 815     





Leu Lys Lys Lys Pro Ser Leu Asp Asp Leu Lys Glu Leu Met Pro Asp 

            820                 825                 830         





Val Gly Arg Ser Met Gln Gln Leu Leu Asp Tyr Pro Glu Asp Asp Ile 

        835                 840                 845             





Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Thr Val Glu Asn Phe Gly 

    850                 855                 860                 





Ala Thr Glu Val Lys Glu Leu Val Leu Asn Gly Ala Asp Thr Ala Val 

865                 870                 875                 880 





Asn Lys Gln Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile 

                885                 890                 895     





Phe Asn Lys Ser Val Ala Ser Leu Phe Asp Ala Phe His Ala Gly Phe 

            900                 905                 910         





His Lys Val Cys Gly Gly Lys Val Leu Leu Leu Phe Gln Pro Asn Glu 

        915                 920                 925             





Leu Gln Ala Met Val Ile Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu 

    930                 935                 940                 





Glu Lys Asn Thr Glu Tyr Lys Gly Glu Tyr Trp Ala Glu His Pro Thr 

945                 950                 955                 960 





Ile Lys Ile Phe Trp Glu Val Phe His Glu Leu Pro Leu Glu Lys Lys 

                965                 970                 975     





Lys Gln Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu 

            980                 985                 990         





Gly Met Lys Ser Leu Lys Leu Val  Ile Gln Ser Thr Gly  Gly Gly Glu 

        995                 1000                 1005             





Glu Tyr  Leu Pro Val Ser His  Thr Cys Phe Asn Leu  Leu Asp Leu 

    1010                 1015                 1020             





Pro Lys  Tyr Thr Glu Lys Glu  Thr Leu Arg Ser Lys  Leu Ile Gln 

    1025                 1030                 1035             





Ala Ile  Asp His Asn Glu Gly  Phe Ser Leu Ile 

    1040                 1045                 





<210>  120

<211>  4531

<212>  DNA

<213>  Homo sapiens



<400>  120

ttccggccag cccctccccc gcctccctcg cgtggccacc tccccctctg ccttctccta       60



cccagtctct tccccaactc tccccacccc tggtgctctc cgccccgctt gcctcccgtt      120



cttccccgcc cgctccatcc gggtcgctga cggctgtctc tggactggac agcagtggcg      180



tccgcttttc tctaaggaac ccgataagaa ctccattttc tgttgatgtg gagacatagg      240



gtacctccaa ctttccgggg tttcagaaga gaatttttta ttgaaactgg aagaccaaaa      300



taattacaag catgttgtgc tggggaaatg catcctttgg gcagctaggt ttgggtggaa      360



ttgatgaaga aattgtacta gagcccagaa aaagtgactt ctttataaat aaaagggtcc      420



gagatgtagg atgtggactc agacatactg tgtttgttct ggatgatgga acagtgtaca      480



catgtggatg taatgatcta ggacagctag gtcatgaaaa atccagaaag aaaccagagc      540



aggttgttgc cctggatgcc caaaatattg tagctgtttc atgtggagaa gctcatacgt      600



tagcgctaaa tgacaaaggc caggtgtatg cttggggtct cgattctgat ggacagcttg      660



gcctggtagg atcagaggaa tgcatcagag tacccagaaa tattaaaagt ttgtcagata      720



tccagattgt acaggttgct tgtggttact atcattcact tgcactttct aaagcaagtg      780



aagtcttctg ttggggacag aataaatatg gccaattggg tttaggtact gactgtaaaa      840



agcaaacttc accgcagctg cttaagtctt tgcttggaat ccctttcatg caagttgcag      900



caggaggagc ccatagtttt gtactcaccc tttctggagc tatctttgga tggggacgca      960



acaagtttgg tcagctaggt cttaatgatg aaaatgatag gtatgttcct aatttactaa     1020



agtcactaag atctcagaaa atagtttata tttgttgtgg agaagatcat actgctgctc     1080



taaccaagga aggtggagtg tttacttttg gagctggagg gtatggtcag ttgggccata     1140



attctaccag tcatgaaata aacccaagga aagtttttga acttatggga agcattgtca     1200



ctgagattgc ttgtggacgg cagcacactt ctgcttttgt tccttcatca ggacgaattt     1260



actcttttgg gcttggtggt aatgggcagc tgggaaccgg ttcaacaagc aacaggaaaa     1320



gcccctttac tgtaaaagga aattggtacc cctataatgg gcagtgtcta ccagatattg     1380



attctgaaga atatttctgt gtaaaaagaa ttttctcagg gggagatcaa agcttttcac     1440



attactctag tccccagaac tgtgggccac cagatgactt cagatgtccc aatccgacaa     1500



agcagatctg gacagtgaat gaagctctaa ttcagaaatg gctgagctat ccttctggaa     1560



ggtttcctgt ggagatagcc aatgagatag atggaacgtt ttcttcctct ggttgcctaa     1620



atggaagttt tttagctgtt agcaatgatg atcactatag aacaggtacc agattttcag     1680



gggttgatat gaatgctgct aggcttttat tccacaaact tatacaacct gatcatccgc     1740



agatatctca gcaggtggca gctagtttgg aaaagaatct tattcctaaa ctgactagct     1800



ccttacctga tgttgaagca ttgaggtttt atcttactct accagaatgt cccctgatga     1860



gtgattccaa caatttcaca acaatagcaa ttccctttgg tacagctctt gtgaacctag     1920



aaaaggcacc actgaaagta cttgaaaact ggtggtcagt acttgaacct ccactattcc     1980



tcaagatagt agaacttttt aaggaagttg tggtacatct tttgaaactc tacaagatcg     2040



gtattccccc ttctgaaaga agaattttca acagttttct tcatactgca ttaaaggttt     2100



tagaaatact acatagggta aatgagaaaa tgggacagat tatacagtat gataaatttt     2160



atatacatga agtacaagaa ttgatagaca taagaaatga ttatatcaac tgggtccaac     2220



agcaggccta tggaatggat gtcaaccatg gattaactga gttggcagat atccctgtta     2280



caatctgtac atatccattt gtatttgatg cccaagcaaa aactactctg ttacagaccg     2340



atgcagtctt acagatgcag atggctattg atcaggccca caggcagaat gtctcctctc     2400



tttttctccc agtgattgaa tctgtgaatc cctgcttaat tctagtggtg cgtagagaaa     2460



atattgtagg agatgcaatg gaagtcctta ggaaaacaaa gaacatagat tacaagaagc     2520



cactcaaggt tatatttgtt ggagaagatg ctgtggatgc aggaggggtg cgcaaagaat     2580



ttttcttgct catcatgagg gaattattgg atcctaaata cggcatgttt aggtattatg     2640



aagattccag gctcatttgg ttttctgata agacatttga agacagtgat ttgttccatt     2700



tgattggtgt tatctgtggc ttagcaattt ataattgtac cattgtggac ctccattttc     2760



ctttggcttt atataagaaa ctactgaaaa agaagccatc cttggatgat ttgaaagaac     2820



taatgcctga tgttgggaga agcatgcaac agttactgga ttatccagaa gatgacatag     2880



aggaaacatt ttgtcttaat tttacgatca cagttgaaaa ctttggtgca acagaagtga     2940



aagagctggt tctaaatggt gcagacacag ctgttaacaa acaaaatcgg caagagtttg     3000



tcgatgctta tgtggattac atattcaata aatcagtggc ttccttattt gatgcttttc     3060



atgcgggctt tcataaggtc tgtggaggaa aagtccttct gctctttcag cctaatgaac     3120



tacaagcaat ggtcattgga aatacaaatt atgattggaa ggaactggaa aagaatacag     3180



aatacaaagg ggaatattgg gcagaacatc ctacgataaa aattttttgg gaagtatttc     3240



acgaattacc attggaaaag aagaaacagt ttctgttatt tttgacaggt agtgatcgca     3300



ttcctattct tggtatgaag agtctgaaac tagtcatcca gtccacagga ggtggtgagg     3360



agtatctccc agtttcccat acttgtttta atcttctgga tcttccaaaa tatacagaaa     3420



aagaaactct acgctctaaa ctgatccaag ctattgatca caatgaaggc ttcagtttaa     3480



tataactttg gagttataac tattcagttt agtgcaaaag cattaaacta tttgtgtttt     3540



tcttgtggtg atgaattcag caaggtgaca gaggtactat tataattctt acttgcagaa     3600



tgttcaatct acgagtgttc atggaagcca aaaaatatta aaggaaaatg aacaaactgt     3660



taatattatt gtacagaacc atggattttt tttgaccatc ttctaataaa catagcaagt     3720



attatgaata cattaaagtt ttactaacat gaattttaag agtttgcata tttcagaaat     3780



gatctggtgt gagtgcatgg aaatattgct taatttttct tcaatcattg agtgaaaaac     3840



ctttaacttt ggcctgcaat agtcatttga ttattttttc attttgtaaa taatgttaag     3900



ttttgtaata aaatagttat gttctgatac cagtacagtt tctatggttg taattgaact     3960



tgaacagact tttaaaggtt aaaaattatg atttaaatct tactctgaga ctctataaaa     4020



agaaaaaaaa ggtagcatgg tggaaacact atcttttctt ttttgctaga ataagtgtct     4080



ttgtgcaaac ctaaatcaca gatagggaat atactacata acctgcagtt cttttctttg     4140



tgaatcctga cacactgata gatgggggat tgtcgatcag agaacttatt aatatttagt     4200



actggaagaa ctctgtctcc acagttgcca gtaataaaaa gaaacattgg ctactatgag     4260



caccaatcac tgggttatag ctttcaaaat tattgatgct gcagtgcttt agagctattt     4320



ccttgaattt aagaaacaaa tcttaacagt tttatggtgc tgatgcttag ttgtctcatg     4380



ccattaaatt gtaaaagtga gttgatgcaa tacatgtgac tttctgctat aatgcaaata     4440



tttatttttt aaatttattt taaaatgccg tgaaaactgt ttaataaaga tttattgttt     4500



taatatttaa actttcaaaa aaaaaaaaaa a                                    4531





<210>  121

<211>  1057

<212>  PRT

<213>  Homo sapiens



<400>  121



Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 

1               5                   10                  15      





Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 

            20                  25                  30          





Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 

        35                  40                  45              





Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 

    50                  55                  60                  





Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 

65                  70                  75                  80  





Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 

                85                  90                  95      





Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 

            100                 105                 110         





Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 

        115                 120                 125             





Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 

    130                 135                 140                 





Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 

145                 150                 155                 160 





Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 

                165                 170                 175     





Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 

            180                 185                 190         





Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 

        195                 200                 205             





Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 

    210                 215                 220                 





Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 

225                 230                 235                 240 





Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 

                245                 250                 255     





Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 

            260                 265                 270         





Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 

        275                 280                 285             





Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 

    290                 295                 300                 





His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 

305                 310                 315                 320 





Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 

                325                 330                 335     





Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 

            340                 345                 350         





Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 

        355                 360                 365             





Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 

    370                 375                 380                 





Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 

385                 390                 395                 400 





Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 

                405                 410                 415     





Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 

            420                 425                 430         





Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 

        435                 440                 445             





Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 

    450                 455                 460                 





Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 

465                 470                 475                 480 





Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 

                485                 490                 495     





Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 

            500                 505                 510         





Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 

        515                 520                 525             





Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 

    530                 535                 540                 





Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 

545                 550                 555                 560 





Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 

                565                 570                 575     





Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 

            580                 585                 590         





Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 

        595                 600                 605             





Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 

    610                 615                 620                 





Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 

625                 630                 635                 640 





Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile Pro Val 

                645                 650                 655     





Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr 

            660                 665                 670         





Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln 

        675                 680                 685             





Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser 

    690                 695                 700                 





Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly 

705                 710                 715                 720 





Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys 

                725                 730                 735     





Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly 

            740                 745                 750         





Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro 

        755                 760                 765             





Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe 

    770                 775                 780                 





Ser Asp Lys Thr Phe Glu Asp Ser Asp Leu Phe His Leu Ile Gly Val 

785                 790                 795                 800 





Ile Cys Gly Leu Ala Ile Tyr Asn Cys Thr Ile Val Asp Leu His Phe 

                805                 810                 815     





Pro Leu Ala Leu Tyr Lys Lys Leu Leu Lys Lys Lys Pro Ser Leu Asp 

            820                 825                 830         





Asp Leu Lys Glu Leu Met Pro Asp Val Gly Arg Ser Met Gln Gln Leu 

        835                 840                 845             





Leu Asp Tyr Pro Glu Asp Asp Ile Glu Glu Thr Phe Cys Leu Asn Phe 

    850                 855                 860                 





Thr Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu Leu Val 

865                 870                 875                 880 





Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln Glu Phe 

                885                 890                 895     





Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala Ser Leu 

            900                 905                 910         





Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly Lys Val 

        915                 920                 925             





Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile Gly Asn 

    930                 935                 940                 





Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr Lys Gly 

945                 950                 955                 960 





Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu Val Phe 

                965                 970                 975     





His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe Leu Thr 

            980                 985                 990         





Gly Ser Asp Arg Ile Pro Ile Leu  Gly Met Lys Ser Leu  Lys Leu Val 

        995                 1000                 1005             





Ile Gln  Ser Thr Gly Gly Gly  Glu Glu Tyr Leu Pro  Val Ser His 

    1010                 1015                 1020             





Thr Cys  Phe Asn Leu Leu Asp  Leu Pro Lys Tyr Thr  Glu Lys Glu 

    1025                 1030                 1035             





Thr Leu  Arg Ser Lys Leu Ile  Gln Ala Ile Asp His  Asn Glu Gly 

    1040                 1045                 1050             





Phe Ser  Leu Ile 

    1055         





<210>  122

<211>  3719

<212>  DNA

<213>  Homo sapiens



<400>  122

atttagtccg caacacctcg ctccccagga ggtctgccag cctggactgg aagcgtgcaa       60



cactccagag tcgtaggagt gaacactgca caggaatctc tgcccatctc aggagaaacc      120



aaacttgggg aaaatgtttg cggtccactt gatggcattt tacttcagca agctgaagga      180



ggaccagatc aagaaggtgg acaggttcct gtatcacatg cggctctccg atgacaccct      240



tttggacatc atgaggcggt tccgggctga gatggagaag ggcctggcaa aggacaccaa      300



ccccacggct gcagtgaaga tgttgcccac cttcgtcagg gccattcccg atggttccga      360



aaatggggag ttcctttccc tggatctcgg agggtccaag ttccgagtgc tgaaggtgca      420



agtcgctgaa gaggggaagc gacacgtgca gatggagagt cagttctacc caacgcccaa      480



tgaaatcatc cgcgggaacg gcacagagct gtttgaatat gtagctgact gtctggcaga      540



tttcatgaag accaaagatt taaagcataa gaaattgccc cttggcctaa ctttttcttt      600



cccctgtcga cagactaaac tggaagaggg tgtcctactt tcgtggacaa aaaagtttaa      660



ggcacgagga gttcaggaca cggatgtggt gagccgtctg accaaagcca tgagaagaca      720



caaggacatg gacgtggaca tcctggccct ggtcaatgac accgtgggga ccatgatgac      780



ctgtgcctat gacgacccct actgcgaagt tggtgtcatc atcggaactg gcaccaatgc      840



gtgttacatg gaggacatga gcaacattga cctggtggag ggcgacgagg gcaggatgtg      900



catcaacaca gagtgggggg ccttcgggga cgacggggcc ctggaggaca ttcgcactga      960



gttcgacagg gagctggacc tcggctctct caacccagga aagcaactgt tcgagaagat     1020



gatcagtggc ctgtacctgg gggagcttgt caggcttatc ttgctgaaga tggccaaggc     1080



tggcctcctg tttggtggtg agaaatcttc tgctctccac actaagggca agatcgaaac     1140



acggcacgtg gctgccatgg agaagtataa agaaggcctt gctaatacaa gagagatcct     1200



ggtggacctg ggtctggaac cgtctgaggc tgactgcatt gccgtccagc atgtctgtac     1260



catcgtctcc ttccgctcgg ccaatctctg tgcagcagct ctggcggcca tcctgacacg     1320



cctccgggag aacaagaagg tggaacggct ccggaccaca gtgggcatgg acggcaccct     1380



ctacaagata caccctcagt acccaaaacg cctgcacaag gtggtgagga aactggtccc     1440



aagctgtgat gtccgcttcc tcctgtcaga gagtggcagc accaaggggg ccgccatggt     1500



gaccgcggtg gcctcccgcg tgcaggccca gcggaagcag atcgacaggg tgctggcttt     1560



gttccagctg acccgagagc agctcgtgga cgtgcaggcc aagatgcggg ctgagctgga     1620



gtatgggctg aagaagaaga gccacgggct ggccacggtc aggatgctgc ccacctacgt     1680



ctgcgggctg ccggacggca cagagaaagg aaagtttctc gccctggatc ttgggggaac     1740



caacttccgg gtcctcctgg tgaagatcag aagtggacgg aggtcagtgc gaatgtacaa     1800



caagatcttc gccatccccc tggagatcat gcagggcact ggtgaggagc tctttgatca     1860



cattgtgcag tgcatcgccg acttcctgga ctacatgggc ctcaagggag cctccctacc     1920



tttgggcttc acattctcat ttccctgcag gcagatgagc attgacaagg gaacactcat     1980



agggtggacc aaaggtttca aggccactga ctgtgaaggg gaggacgtgg tggacatgct     2040



cagggaagcc atcaagagga gaaacgagtt tgacctggac attgttgcag tcgtgaatga     2100



tacagtgggg accatgatga cctgtggcta tgaagatcct aattgtgaga ttggcctgat     2160



tgcaggaaca ggcagcaaca tgtgctacat ggaggacatg aggaacatcg agatggtgga     2220



ggggggtgaa gggaagatgt gcatcaatac agagtgggga ggatttggag acaatggctg     2280



catagatgac atccggaccc gatacgacac ggaggtggat gaggggtcct tgaatcctgg     2340



caagcagaga tacgagaaaa tgaccagtgg gatgtacttg ggggagattg tgcggcagat     2400



cctgatcgac ctgaccaagc agggtctcct cttccgaggg cagatttcag agcgtctccg     2460



gaccaggggc atcttcgaaa ccaagttcct gtcccagatc gaaagcgatc ggctggccct     2520



tctccaggtc aggaggattc tgcagcagct gggcctggac agcacgtgtg aggacagcat     2580



cgtggtgaag gaggtgtgcg gagccgtgtc ccggcgggcg gcccagctct gcggtgctgg     2640



cctggccgct atagtggaaa aaaggagaga agaccagggg ctagagcacc tgaggatcac     2700



tgtgggtgtg gacggcaccc tgtacaagct gcaccctcac ttttctagaa tattgcagga     2760



aactgtgaag gaactagccc ctcgatgtga tgtgacattc atgctgtcag aagatggcag     2820



tggaaaaggg gcagcactga tcactgctgt ggccaagagg ttacagcagg cacagaagga     2880



gaactaggaa cccctgggat tggacctgat gcatcttgga tactgaacag cttttcctct     2940



ggcagatcag ttggtcagag accaatgggc accctcctgg ctgacctcac cttctggatg     3000



gccgaaagag aaccccaggt tctcgggtac tcttagtatc ttgtactgga tttgcagtga     3060



cattacatga catctctatt tggtatattt gggccaaaat gggccaactt atgaaatcaa     3120



agtgtctgtc ctgagagatc ccctttcaac acattgttca ggtgaggctt gagctgtcaa     3180



ttctctatgg ctttcagtct tgtggctgcg ggacttggaa atatatagaa tctgcccatg     3240



tggctggcag gctgtttccc cattgggatg cttaagccat ctcttatagg ggattggacc     3300



ctgtacttgt ggatgaacat tggagagcaa gaggaactca cgttatgaac tagggggatc     3360



tcatctaact tgtccttaac ttgccatgtt gacttcaaac ctgttaagag aacaaagact     3420



ttgaagtatc cagccccagg gtgcagagag gttgattgcc agggagcact gcaggaatca     3480



ttgcatgctt aaagcgagtt atgtcagcac cctgtaggat tttgttcctt attaagtgtg     3540



tgccatgtgg tggggtgctg tctggggcat ctgtttttca ttttgcctgt ggtttgtgtt     3600



gcaggtgttg atagttgttt taaggattgt taggtatagg aaatccagta aattaataaa     3660



aaaattttga ttttccaata aactttgcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      3719





<210>  123

<211>  917

<212>  PRT

<213>  Homo sapiens



<400>  123



Met Phe Ala Val His Leu Met Ala Phe Tyr Phe Ser Lys Leu Lys Glu 

1               5                   10                  15      





Asp Gln Ile Lys Lys Val Asp Arg Phe Leu Tyr His Met Arg Leu Ser 

            20                  25                  30          





Asp Asp Thr Leu Leu Asp Ile Met Arg Arg Phe Arg Ala Glu Met Glu 

        35                  40                  45              





Lys Gly Leu Ala Lys Asp Thr Asn Pro Thr Ala Ala Val Lys Met Leu 

    50                  55                  60                  





Pro Thr Phe Val Arg Ala Ile Pro Asp Gly Ser Glu Asn Gly Glu Phe 

65                  70                  75                  80  





Leu Ser Leu Asp Leu Gly Gly Ser Lys Phe Arg Val Leu Lys Val Gln 

                85                  90                  95      





Val Ala Glu Glu Gly Lys Arg His Val Gln Met Glu Ser Gln Phe Tyr 

            100                 105                 110         





Pro Thr Pro Asn Glu Ile Ile Arg Gly Asn Gly Thr Glu Leu Phe Glu 

        115                 120                 125             





Tyr Val Ala Asp Cys Leu Ala Asp Phe Met Lys Thr Lys Asp Leu Lys 

    130                 135                 140                 





His Lys Lys Leu Pro Leu Gly Leu Thr Phe Ser Phe Pro Cys Arg Gln 

145                 150                 155                 160 





Thr Lys Leu Glu Glu Gly Val Leu Leu Ser Trp Thr Lys Lys Phe Lys 

                165                 170                 175     





Ala Arg Gly Val Gln Asp Thr Asp Val Val Ser Arg Leu Thr Lys Ala 

            180                 185                 190         





Met Arg Arg His Lys Asp Met Asp Val Asp Ile Leu Ala Leu Val Asn 

        195                 200                 205             





Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Asp Asp Pro Tyr Cys 

    210                 215                 220                 





Glu Val Gly Val Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 

225                 230                 235                 240 





Asp Met Ser Asn Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 

                245                 250                 255     





Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ala Leu Glu Asp 

            260                 265                 270         





Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Leu Gly Ser Leu Asn Pro 

        275                 280                 285             





Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Leu Tyr Leu Gly Glu 

    290                 295                 300                 





Leu Val Arg Leu Ile Leu Leu Lys Met Ala Lys Ala Gly Leu Leu Phe 

305                 310                 315                 320 





Gly Gly Glu Lys Ser Ser Ala Leu His Thr Lys Gly Lys Ile Glu Thr 

                325                 330                 335     





Arg His Val Ala Ala Met Glu Lys Tyr Lys Glu Gly Leu Ala Asn Thr 

            340                 345                 350         





Arg Glu Ile Leu Val Asp Leu Gly Leu Glu Pro Ser Glu Ala Asp Cys 

        355                 360                 365             





Ile Ala Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 

    370                 375                 380                 





Leu Cys Ala Ala Ala Leu Ala Ala Ile Leu Thr Arg Leu Arg Glu Asn 

385                 390                 395                 400 





Lys Lys Val Glu Arg Leu Arg Thr Thr Val Gly Met Asp Gly Thr Leu 

                405                 410                 415     





Tyr Lys Ile His Pro Gln Tyr Pro Lys Arg Leu His Lys Val Val Arg 

            420                 425                 430         





Lys Leu Val Pro Ser Cys Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 

        435                 440                 445             





Ser Thr Lys Gly Ala Ala Met Val Thr Ala Val Ala Ser Arg Val Gln 

    450                 455                 460                 





Ala Gln Arg Lys Gln Ile Asp Arg Val Leu Ala Leu Phe Gln Leu Thr 

465                 470                 475                 480 





Arg Glu Gln Leu Val Asp Val Gln Ala Lys Met Arg Ala Glu Leu Glu 

                485                 490                 495     





Tyr Gly Leu Lys Lys Lys Ser His Gly Leu Ala Thr Val Arg Met Leu 

            500                 505                 510         





Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly Thr Glu Lys Gly Lys Phe 

        515                 520                 525             





Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 

    530                 535                 540                 





Ile Arg Ser Gly Arg Arg Ser Val Arg Met Tyr Asn Lys Ile Phe Ala 

545                 550                 555                 560 





Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His 

                565                 570                 575     





Ile Val Gln Cys Ile Ala Asp Phe Leu Asp Tyr Met Gly Leu Lys Gly 

            580                 585                 590         





Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln Met 

        595                 600                 605             





Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp Thr Lys Gly Phe Lys Ala 

    610                 615                 620                 





Thr Asp Cys Glu Gly Glu Asp Val Val Asp Met Leu Arg Glu Ala Ile 

625                 630                 635                 640 





Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile Val Ala Val Val Asn Asp 

                645                 650                 655     





Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro Asn Cys Glu 

            660                 665                 670         





Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn Met Cys Tyr Met Glu Asp 

        675                 680                 685             





Met Arg Asn Ile Glu Met Val Glu Gly Gly Glu Gly Lys Met Cys Ile 

    690                 695                 700                 





Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn Gly Cys Ile Asp Asp Ile 

705                 710                 715                 720 





Arg Thr Arg Tyr Asp Thr Glu Val Asp Glu Gly Ser Leu Asn Pro Gly 

                725                 730                 735     





Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly Met Tyr Leu Gly Glu Ile 

            740                 745                 750         





Val Arg Gln Ile Leu Ile Asp Leu Thr Lys Gln Gly Leu Leu Phe Arg 

        755                 760                 765             





Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg Gly Ile Phe Glu Thr Lys 

    770                 775                 780                 





Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg 

785                 790                 795                 800 





Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser Thr Cys Glu Asp Ser Ile 

                805                 810                 815     





Val Val Lys Glu Val Cys Gly Ala Val Ser Arg Arg Ala Ala Gln Leu 

            820                 825                 830         





Cys Gly Ala Gly Leu Ala Ala Ile Val Glu Lys Arg Arg Glu Asp Gln 

        835                 840                 845             





Gly Leu Glu His Leu Arg Ile Thr Val Gly Val Asp Gly Thr Leu Tyr 

    850                 855                 860                 





Lys Leu His Pro His Phe Ser Arg Ile Leu Gln Glu Thr Val Lys Glu 

865                 870                 875                 880 





Leu Ala Pro Arg Cys Asp Val Thr Phe Met Leu Ser Glu Asp Gly Ser 

                885                 890                 895     





Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Lys Arg Leu Gln Gln 

            900                 905                 910         





Ala Gln Lys Glu Asn 

        915         





<210>  124

<211>  2339

<212>  DNA

<213>  Homo sapiens



<400>  124

acgcggtgcc gcggggcggg agtagaggcg gagggagggg acacgggctc attgcggtgt       60



gcgccctgca ctctgtccct cactcgccgc cgacgacctg tctcgccgag cgcacgcctt      120



gccgccgccc cgcagaaatg cttcggttac ccacagtctt tcgccagatg agaccggtgt      180



ccagggtact ggctcctcat ctcactcggg cttatgccaa agatgtaaaa tttggtgcag      240



atgcccgagc cttaatgctt caaggtgtag accttttagc cgatgctgtg gccgttacaa      300



tggggccaaa gggaagaaca gtgattattg agcagagttg gggaagtccc aaagtaacaa      360



aagatggtgt gactgttgca aagtcaattg acttaaaaga taaatacaaa aacattggag      420



ctaaacttgt tcaagatgtt gccaataaca caaatgaaga agctggggat ggcactacca      480



ctgctactgt actggcacgc tctatagcca aggaaggctt cgagaagatt agcaaaggtg      540



ctaatccagt ggaaatcagg agaggtgtga tgttagctgt tgatgctgta attgctgaac      600



ttaaaaagca gtctaaacct gtgaccaccc ctgaagaaat tgcacaggtt gctacgattt      660



ctgcaaacgg agacaaagaa attggcaata tcatctctga tgcaatgaaa aaagttggaa      720



gaaagggtgt catcacagta aaggatggaa aaacactgaa tgatgaatta gaaattattg      780



aaggcatgaa gtttgatcga ggctatattt ctccatactt tattaataca tcaaaaggtc      840



agaaatgtga attccaggat gcctatgttc tgttgagtga aaagaaaatt tctagtatcc      900



agtccattgt acctgctctt gaaattgcca atgctcaccg taagcctttg gtcataatcg      960



ctgaagatgt tgatggagaa gctctaagta cactcgtctt gaataggcta aaggttggtc     1020



ttcaggttgt ggcagtcaag gctccagggt ttggtgacaa tagaaagaac cagcttaaag     1080



atatggctat tgctactggt ggtgcagtgt ttggagaaga gggattgacc ctgaatcttg     1140



aagacgttca gcctcatgac ttaggaaaag ttggagaggt cattgtgacc aaagacgatg     1200



ccatgctctt aaaaggaaaa ggtgacaagg ctcaaattga aaaacgtatt caagaaatca     1260



ttgagcagtt agatgtcaca actagtgaat atgaaaagga aaaactgaat gaacggcttg     1320



caaaactttc agatggagtg gctgtgctga aggttggtgg gacaagtgat gttgaagtga     1380



atgaaaagaa agacagagtt acagatgccc ttaatgctac aagagctgct gttgaagaag     1440



gcattgtttt gggagggggt tgtgccctcc ttcgatgcat tccagccttg gactcattga     1500



ctccagctaa tgaagatcaa aaaattggta tagaaattat taaaagaaca ctcaaaattc     1560



cagcaatgac cattgctaag aatgcaggtg ttgaaggatc tttgatagtt gagaaaatta     1620



tgcaaagttc ctcagaagtt ggttatgatg ctatggctgg agattttgtg aatatggtgg     1680



aaaaaggaat cattgaccca acaaaggttg tgagaactgc tttattggat gctgctggtg     1740



tggcctctct gttaactaca gcagaagttg tagtcacaga aattcctaaa gaagagaagg     1800



accctggaat gggtgcaatg ggtggaatgg gaggtggtat gggaggtggc atgttctaac     1860



tcctagacta gtgctttacc tttattaatg aactgtgaca ggaagcccaa ggcagtgttc     1920



ctcaccaata acttcagaga agtcagttgg agaaaatgaa gaaaaaggct ggctgaaaat     1980



cactataacc atcagttact ggtttcagtt gacaaaatat ataatggttt actgctgtca     2040



ttgtccatgc ctacagataa tttattttgt atttttgaat aaaaaacatt tgtacattcc     2100



tgatactggg tacaagagcc atgtaccagt gtactgcttt caacttaaat cactgaggca     2160



tttttactac tattctgtta aaatcaggat tttagtgctt gccaccacca gatgagaagt     2220



taagcagcct ttctgtggag agtgagaata attgtgtaca aagtagagaa gtatccaatt     2280



atgtgacaac ctttgtgtaa taaaaatttg tttaaagtta aaaaaaaaaa aaaaaaaaa      2339





<210>  125

<211>  573

<212>  PRT

<213>  Homo sapiens



<400>  125



Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 

1               5                   10                  15      





Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 

            20                  25                  30          





Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 

        35                  40                  45              





Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 

    50                  55                  60                  





Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 

65                  70                  75                  80  





Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 

                85                  90                  95      





Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 

            100                 105                 110         





Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 

        115                 120                 125             





Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 

    130                 135                 140                 





Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 

145                 150                 155                 160 





Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 

                165                 170                 175     





Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 

            180                 185                 190         





Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 

        195                 200                 205             





Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 

    210                 215                 220                 





Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 

225                 230                 235                 240 





Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 

                245                 250                 255     





Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 

            260                 265                 270         





Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 

        275                 280                 285             





Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 

    290                 295                 300                 





Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 

305                 310                 315                 320 





Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 

                325                 330                 335     





Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 

            340                 345                 350         





Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 

        355                 360                 365             





Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 

    370                 375                 380                 





Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 

385                 390                 395                 400 





Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 

                405                 410                 415     





Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 

            420                 425                 430         





Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 

        435                 440                 445             





Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 

    450                 455                 460                 





Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 

465                 470                 475                 480 





Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 

                485                 490                 495     





Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 

            500                 505                 510         





Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 

        515                 520                 525             





Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 

    530                 535                 540                 





Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 

545                 550                 555                 560 





Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 

                565                 570             





<210>  126

<211>  2319

<212>  DNA

<213>  Homo sapiens



<400>  126

gccccgacgc gcaccgcgat tcgccccaag ggccctgcgc aggacgctga cgcgaagact       60



cggaggcgga agaaaaaagg agctgtttct aggcttttct aggcgcccag ccgagaaatg      120



cttcggttac ccacagtctt tcgccagatg agaccggtgt ccagggtact ggctcctcat      180



ctcactcggg cttatgccaa agatgtaaaa tttggtgcag atgcccgagc cttaatgctt      240



caaggtgtag accttttagc cgatgctgtg gccgttacaa tggggccaaa gggaagaaca      300



gtgattattg agcagagttg gggaagtccc aaagtaacaa aagatggtgt gactgttgca      360



aagtcaattg acttaaaaga taaatacaaa aacattggag ctaaacttgt tcaagatgtt      420



gccaataaca caaatgaaga agctggggat ggcactacca ctgctactgt actggcacgc      480



tctatagcca aggaaggctt cgagaagatt agcaaaggtg ctaatccagt ggaaatcagg      540



agaggtgtga tgttagctgt tgatgctgta attgctgaac ttaaaaagca gtctaaacct      600



gtgaccaccc ctgaagaaat tgcacaggtt gctacgattt ctgcaaacgg agacaaagaa      660



attggcaata tcatctctga tgcaatgaaa aaagttggaa gaaagggtgt catcacagta      720



aaggatggaa aaacactgaa tgatgaatta gaaattattg aaggcatgaa gtttgatcga      780



ggctatattt ctccatactt tattaataca tcaaaaggtc agaaatgtga attccaggat      840



gcctatgttc tgttgagtga aaagaaaatt tctagtatcc agtccattgt acctgctctt      900



gaaattgcca atgctcaccg taagcctttg gtcataatcg ctgaagatgt tgatggagaa      960



gctctaagta cactcgtctt gaataggcta aaggttggtc ttcaggttgt ggcagtcaag     1020



gctccagggt ttggtgacaa tagaaagaac cagcttaaag atatggctat tgctactggt     1080



ggtgcagtgt ttggagaaga gggattgacc ctgaatcttg aagacgttca gcctcatgac     1140



ttaggaaaag ttggagaggt cattgtgacc aaagacgatg ccatgctctt aaaaggaaaa     1200



ggtgacaagg ctcaaattga aaaacgtatt caagaaatca ttgagcagtt agatgtcaca     1260



actagtgaat atgaaaagga aaaactgaat gaacggcttg caaaactttc agatggagtg     1320



gctgtgctga aggttggtgg gacaagtgat gttgaagtga atgaaaagaa agacagagtt     1380



acagatgccc ttaatgctac aagagctgct gttgaagaag gcattgtttt gggagggggt     1440



tgtgccctcc ttcgatgcat tccagccttg gactcattga ctccagctaa tgaagatcaa     1500



aaaattggta tagaaattat taaaagaaca ctcaaaattc cagcaatgac cattgctaag     1560



aatgcaggtg ttgaaggatc tttgatagtt gagaaaatta tgcaaagttc ctcagaagtt     1620



ggttatgatg ctatggctgg agattttgtg aatatggtgg aaaaaggaat cattgaccca     1680



acaaaggttg tgagaactgc tttattggat gctgctggtg tggcctctct gttaactaca     1740



gcagaagttg tagtcacaga aattcctaaa gaagagaagg accctggaat gggtgcaatg     1800



ggtggaatgg gaggtggtat gggaggtggc atgttctaac tcctagacta gtgctttacc     1860



tttattaatg aactgtgaca ggaagcccaa ggcagtgttc ctcaccaata acttcagaga     1920



agtcagttgg agaaaatgaa gaaaaaggct ggctgaaaat cactataacc atcagttact     1980



ggtttcagtt gacaaaatat ataatggttt actgctgtca ttgtccatgc ctacagataa     2040



tttattttgt atttttgaat aaaaaacatt tgtacattcc tgatactggg tacaagagcc     2100



atgtaccagt gtactgcttt caacttaaat cactgaggca tttttactac tattctgtta     2160



aaatcaggat tttagtgctt gccaccacca gatgagaagt taagcagcct ttctgtggag     2220



agtgagaata attgtgtaca aagtagagaa gtatccaatt atgtgacaac ctttgtgtaa     2280



taaaaatttg tttaaagtta aaaaaaaaaa aaaaaaaaa                            2319





<210>  127

<211>  573

<212>  PRT

<213>  Homo sapiens



<400>  127



Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 

1               5                   10                  15      





Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 

            20                  25                  30          





Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 

        35                  40                  45              





Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 

    50                  55                  60                  





Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 

65                  70                  75                  80  





Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 

                85                  90                  95      





Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 

            100                 105                 110         





Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 

        115                 120                 125             





Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 

    130                 135                 140                 





Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 

145                 150                 155                 160 





Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 

                165                 170                 175     





Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 

            180                 185                 190         





Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 

        195                 200                 205             





Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 

    210                 215                 220                 





Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 

225                 230                 235                 240 





Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 

                245                 250                 255     





Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 

            260                 265                 270         





Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 

        275                 280                 285             





Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 

    290                 295                 300                 





Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 

305                 310                 315                 320 





Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 

                325                 330                 335     





Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 

            340                 345                 350         





Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 

        355                 360                 365             





Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 

    370                 375                 380                 





Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 

385                 390                 395                 400 





Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 

                405                 410                 415     





Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 

            420                 425                 430         





Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 

        435                 440                 445             





Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 

    450                 455                 460                 





Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 

465                 470                 475                 480 





Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 

                485                 490                 495     





Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 

            500                 505                 510         





Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 

        515                 520                 525             





Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 

    530                 535                 540                 





Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 

545                 550                 555                 560 





Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 

                565                 570             





<210>  128

<211>  2232

<212>  DNA

<213>  Homo sapiens



<400>  128

ggcccggggg cggagcaagg caaggaagcg gaagcggaga ggcggtcggg atccgctgcg       60



cgagctgtct cggtcccacg tgtgcgagtt gctacgatgg aagttaaagg gaaaaagcaa      120



ttcacaggaa agagtacaaa gacagcacaa gaaaaaaaca gatttcataa aaatagtgat      180



tctggttctt caaagacatt tccaacaagg aaagttgcta aagaaggtgg acctaaagtc      240



acatctagga actttgagaa aagtatcaca aaacttggga aaaagggtgt aaagcagttc      300



aagaataagc agcaagggga caaatcacca aagaacaaat tccagccggc aaataaattc      360



aacaagaaga gaaaattcca gccagatggt agaagcgatg aatcagcagc caagaagccc      420



aaatgggatg acttcaaaaa gaagaagaaa gaactgaagc aaagcagaca actcagtgat      480



aaaaccaact atgacattgt tgttcgggca aagcagatgt gggagatttt aagaagaaaa      540



gactgtgaca aagaaaaaag agtaaagtta atgagtgatt tgcagaagtt gattcaaggg      600



aaaattaaaa ctattgcatt tgcacacgat tcaactcgtg tgatccagtg ttacattcag      660



tatggtaatg aagaacagag aaaacaggct tttgaagaat tgcgagatga tttggttgag      720



ttaagtaaag ccaaatattc gagaaatatt gttaagaaat ttctcatgta tggaagtaaa      780



ccacagattg cagagataat cagaagtttt aaaggccacg tgaggaagat gctgcggcat      840



gcggaagcat cagccatcgt ggagtacgca tacaatgaca aagccatttt ggagcagagg      900



aacatgctga cggaagagct ctatgggaac acatttcagc tttacaagtc agcagatcac      960



cgaactctgg acaaagtgtt agaggtacag ccagaaaaat tagaacttat tatggatgaa     1020



atgaaacaga ttctaactcc aatggcccaa aaggaagctg tgattaagca ctcattggtg     1080



cataaagtat tcttggactt ttttacctat gcacccccca aactcagatc agaaatgatt     1140



gaagccatcc gcgaagcggt ggtctacctg gcacacacac acgatggcgc cagagtggcc     1200



atgcactgcc tgtggcatgg cacgcccaag gacaggaaag tgattgtgaa aacaatgaag     1260



acttatgttg aaaaggtggc taatggccaa tactcccatt tggttttact ggcggcattt     1320



gattgtattg atgatactaa gcttgtgaag cagataatca tatcagaaat tatcagttca     1380



ttgcctagca tagtaaatga caaatatgga aggaaggtcc tattgtactt actaagcccc     1440



agagatcctg cacatacagt acgagaaatc attgaagttc tgcaaaaagg agatggaaat     1500



gcacacagta agaaagatac agaggtccgc agacgggagc tcctagaatc catttctcca     1560



gctttgttaa gctacctgca agaacacgcc caagaagtgg tgctagataa gtctgcgtgt     1620



gtgttggtgt ctgacattct gggatctgcc actggagacg ttcagcctac catgaatgcc     1680



atcgccagct tggcagcaac aggactgcat cctggtggca aggacggaga gcttcacatt     1740



gcagaacatc ctgcaggaca tctagttctg aagtggttaa tagagcaaga taaaaagatg     1800



aaagaaaatg ggagagaagg ttgttttgca aaaacacttg tagagcatgt tggtatgaag     1860



aacctgaagt cctgggctag tgtaaatcga ggtgccatta ttctttctag cctcctccag     1920



agttgtgacc tggaagttgc aaacaaagtc aaagctgcac tgaaaagctt gattcctaca     1980



ttggaaaaaa ccaaaagcac cagcaaagga atagaaattc tacttgaaaa actgagcaca     2040



taggtggaaa gagttaagag caagatggaa tgattttttc tgttctctgt tctgtttccc     2100



aatgcagaaa agaaggggta gggtccacca tactggtaat tggggtactc tgtatatgtg     2160



tttcttcttt gtatacgaat ctatttatat aaattgtttt tttaaatggt cttttttaaa     2220



aaaaaaaaaa aa                                                         2232





<210>  129

<211>  648

<212>  PRT

<213>  Homo sapiens



<400>  129



Met Glu Val Lys Gly Lys Lys Gln Phe Thr Gly Lys Ser Thr Lys Thr 

1               5                   10                  15      





Ala Gln Glu Lys Asn Arg Phe His Lys Asn Ser Asp Ser Gly Ser Ser 

            20                  25                  30          





Lys Thr Phe Pro Thr Arg Lys Val Ala Lys Glu Gly Gly Pro Lys Val 

        35                  40                  45              





Thr Ser Arg Asn Phe Glu Lys Ser Ile Thr Lys Leu Gly Lys Lys Gly 

    50                  55                  60                  





Val Lys Gln Phe Lys Asn Lys Gln Gln Gly Asp Lys Ser Pro Lys Asn 

65                  70                  75                  80  





Lys Phe Gln Pro Ala Asn Lys Phe Asn Lys Lys Arg Lys Phe Gln Pro 

                85                  90                  95      





Asp Gly Arg Ser Asp Glu Ser Ala Ala Lys Lys Pro Lys Trp Asp Asp 

            100                 105                 110         





Phe Lys Lys Lys Lys Lys Glu Leu Lys Gln Ser Arg Gln Leu Ser Asp 

        115                 120                 125             





Lys Thr Asn Tyr Asp Ile Val Val Arg Ala Lys Gln Met Trp Glu Ile 

    130                 135                 140                 





Leu Arg Arg Lys Asp Cys Asp Lys Glu Lys Arg Val Lys Leu Met Ser 

145                 150                 155                 160 





Asp Leu Gln Lys Leu Ile Gln Gly Lys Ile Lys Thr Ile Ala Phe Ala 

                165                 170                 175     





His Asp Ser Thr Arg Val Ile Gln Cys Tyr Ile Gln Tyr Gly Asn Glu 

            180                 185                 190         





Glu Gln Arg Lys Gln Ala Phe Glu Glu Leu Arg Asp Asp Leu Val Glu 

        195                 200                 205             





Leu Ser Lys Ala Lys Tyr Ser Arg Asn Ile Val Lys Lys Phe Leu Met 

    210                 215                 220                 





Tyr Gly Ser Lys Pro Gln Ile Ala Glu Ile Ile Arg Ser Phe Lys Gly 

225                 230                 235                 240 





His Val Arg Lys Met Leu Arg His Ala Glu Ala Ser Ala Ile Val Glu 

                245                 250                 255     





Tyr Ala Tyr Asn Asp Lys Ala Ile Leu Glu Gln Arg Asn Met Leu Thr 

            260                 265                 270         





Glu Glu Leu Tyr Gly Asn Thr Phe Gln Leu Tyr Lys Ser Ala Asp His 

        275                 280                 285             





Arg Thr Leu Asp Lys Val Leu Glu Val Gln Pro Glu Lys Leu Glu Leu 

    290                 295                 300                 





Ile Met Asp Glu Met Lys Gln Ile Leu Thr Pro Met Ala Gln Lys Glu 

305                 310                 315                 320 





Ala Val Ile Lys His Ser Leu Val His Lys Val Phe Leu Asp Phe Phe 

                325                 330                 335     





Thr Tyr Ala Pro Pro Lys Leu Arg Ser Glu Met Ile Glu Ala Ile Arg 

            340                 345                 350         





Glu Ala Val Val Tyr Leu Ala His Thr His Asp Gly Ala Arg Val Ala 

        355                 360                 365             





Met His Cys Leu Trp His Gly Thr Pro Lys Asp Arg Lys Val Ile Val 

    370                 375                 380                 





Lys Thr Met Lys Thr Tyr Val Glu Lys Val Ala Asn Gly Gln Tyr Ser 

385                 390                 395                 400 





His Leu Val Leu Leu Ala Ala Phe Asp Cys Ile Asp Asp Thr Lys Leu 

                405                 410                 415     





Val Lys Gln Ile Ile Ile Ser Glu Ile Ile Ser Ser Leu Pro Ser Ile 

            420                 425                 430         





Val Asn Asp Lys Tyr Gly Arg Lys Val Leu Leu Tyr Leu Leu Ser Pro 

        435                 440                 445             





Arg Asp Pro Ala His Thr Val Arg Glu Ile Ile Glu Val Leu Gln Lys 

    450                 455                 460                 





Gly Asp Gly Asn Ala His Ser Lys Lys Asp Thr Glu Val Arg Arg Arg 

465                 470                 475                 480 





Glu Leu Leu Glu Ser Ile Ser Pro Ala Leu Leu Ser Tyr Leu Gln Glu 

                485                 490                 495     





His Ala Gln Glu Val Val Leu Asp Lys Ser Ala Cys Val Leu Val Ser 

            500                 505                 510         





Asp Ile Leu Gly Ser Ala Thr Gly Asp Val Gln Pro Thr Met Asn Ala 

        515                 520                 525             





Ile Ala Ser Leu Ala Ala Thr Gly Leu His Pro Gly Gly Lys Asp Gly 

    530                 535                 540                 





Glu Leu His Ile Ala Glu His Pro Ala Gly His Leu Val Leu Lys Trp 

545                 550                 555                 560 





Leu Ile Glu Gln Asp Lys Lys Met Lys Glu Asn Gly Arg Glu Gly Cys 

                565                 570                 575     





Phe Ala Lys Thr Leu Val Glu His Val Gly Met Lys Asn Leu Lys Ser 

            580                 585                 590         





Trp Ala Ser Val Asn Arg Gly Ala Ile Ile Leu Ser Ser Leu Leu Gln 

        595                 600                 605             





Ser Cys Asp Leu Glu Val Ala Asn Lys Val Lys Ala Ala Leu Lys Ser 

    610                 615                 620                 





Leu Ile Pro Thr Leu Glu Lys Thr Lys Ser Thr Ser Lys Gly Ile Glu 

625                 630                 635                 640 





Ile Leu Leu Glu Lys Leu Ser Thr 

                645             





<210>  130

<211>  3860

<212>  DNA

<213>  Homo sapiens



<400>  130

agagctgcca gggattggcc agaacttggc tttgagtcac aaagctgctg cggcaccagg       60



gctccaagac tggccgttca gactgctagg tttagcttca ggggcagccc agggcagtgt      120



tgctgcatat tgcatggatg aaaggctgaa ggctgcctcc tcttgcaggc tggcttctga      180



gattgcacct tcttctcctg ctactcctcc aaatctatga cccttcaagg cagagctgac      240



ctgtccggta atcaaggcaa tgcagccggc cgcctagcta cagttcacga gccagttgtc      300



acccagtggg cggtgcatcc tccagccccc gctcacccca gtctcctgga caaaatggag      360



aaagcgcctc cacagcccca gcacgagggc ctcaagtcca aggagcatct tccgcaacag      420



cctgccgaag gcaagacggc gtcccgccgc gtcccacgcc tccgggctgt ggtcgagagc      480



caggccttca agaacatcct ggtagacgag atggacatga tgcacgcccg tgcagccacg      540



ctcatccaag ccaactggag gggctattgg ctccggcaga agctgatttc ccagatgatg      600



gcggccaagg ccatccagga ggcctggcgg cgcttcaaca agagacacat ccttcactcc      660



agcaagtcgt tggtaaagaa aacgagggcg gaggaggggg acatacctta tcacgcccca      720



cagcaggtgc gcttccagca tccggaagag aaccgccttc tgtccccgcc catcatggtg      780



aacaaggaga cccagttccc ttcctgtgac aatctggtcc tctgcagacc ccagtcgtcc      840



cccctcctgc agcccccagc agctcagggt accccagagc cctgtgtgca gggtcctcat      900



gctgccagag tccgggggct ggccttcctg ccacaccaga cggtcaccat cagatttccc      960



tgcccagtga gtctggacgc aaaatgccag ccatgcctgc tgaccagaac catcagaagc     1020



acctgcctcg tccacataga gggtgactca gtgaagacca aacgtgtaag tgcccggacc     1080



aacaaagcca gggctccgga gacaccattg tccagaaggt atgaccaggc agttacgaga     1140



ccatccagag cccaaaccca gggccctgtg aaagcagaga cccccaaagc ccccttccag     1200



atatgtccag ggcccatgat caccaagact ctactccaga catatccagt ggtctccgtg     1260



accctgccac agacatatcc agcgtccacg atgaccacca ccccacccaa gactagccca     1320



gttcccaaag taacaataat caagacccca gcccagatgt atccggggcc cacagtgacc     1380



aaaactgcac ctcacacatg ccccatgccc acaatgacca agatccaggt acaccccaca     1440



gcctccagaa ctggcacccc acggcagaca tgccctgcga ccatcacggc aaagaaccga     1500



cctcaggttt cccttctggc ttccatcatg aagagcctgc cccaggtatg cccggggcct     1560



gcgatggcaa agaccccacc ccagatgcac ccggtcacca ccccagccaa aaacccattg     1620



caaacatgtc tgtcagccac aatgtccaag acttcatccc agaggagccc agttggggtg     1680



accaagccct caccccagac ccgcctgcca gccatgataa ccaagacccc agcccagtta     1740



cgctcggtgg ccaccatcct caagactctg tgtctggcct ctccaacagt ggcaaatgtc     1800



aaggctccac cccaagtggc ggtagcagcc ggaactccca acacctcagg ctccatccat     1860



gagaacccac ccaaggccaa ggccaccgtg aatgtgaagc aggctgcaaa ggtggtgaaa     1920



gcctcatccc cctcctattt ggctgagggg aagatcaggt gcctggctca accacatccg     1980



ggaactgggg tccccagggc tgcagctgag cttcctttgg aagccgagaa aatcaagact     2040



ggcacccaga aacaggcgaa aacagacatg gcatttaaga ccagtgtggc agtggaaatg     2100



gctggggctc catcctggac aaaagttgct gaggaagggg acaagccacc tcacgtgtat     2160



gtgcctgtag acatggctgt caccctgccc cggggacagc tggctgcccc actgaccaat     2220



gcctcatccc agagacatcc accctgcctg tcccagagac cactggccgc cccgctgacc     2280



aaggcctcat ctcagggaca tctgcccact gagctgacca agaccccatc cctggcccat     2340



ctggacacct gtctgagcaa gatgcattcc cagacacatc tggccacagg tgccgtgaag     2400



gtccagtccc aagcgcctct agccacctgt ctgaccaaga cgcagtcccg ggggcagccg     2460



atcacagaca taaccacgtg cctcatccca gcgcaccagg ctgctgatct cagcagcaac     2520



acccactccc aggtgctcct aacagggtcc aaggtgtcca accacgcctg ccagcgcctc     2580



ggtggcctca gcgccccacc ctgggccaag ccagaggaca gacagaccca gccacagccc     2640



cacggacacg tgccggggaa gaccactcag gggggaccat gcccggcagc ctgtgaggtc     2700



cagggtatgc tggtgccgcc gatggcaccc accggccatt ccacatgcaa cgttgagtcc     2760



tggggagaca acggagccac acgtgcccag ccatcaatgc ccggccaggc ggtgccctgc     2820



caggaggaca cgggccccgc ggacgctggt gtggttggtg gccaatcgtg gaaccgcgca     2880



tgggagccag ccaggggtgc tgcgtcctgg gacacctggc gcaacaaggc ggtggtgcct     2940



cccaggcggt ccggggagcc aatggtgtcc atgcaggctg cagaggagat ccgcatcctc     3000



gcagtgatca ctatccaggc gggcgtccgt ggctacctgg cgcgtcgcag gatccggctg     3060



tggcaccggg gggccatggt catccaagct acttggcgcg gctaccgtgt gcggcggaac     3120



ctggcacacc tctgcagagc caccacgacc atccagtctg cctggcgcgg ctacagcacc     3180



cgccgggacc aagcccggca ctggcagatg ctccaccccg tcacgtgggt ggagctgggc     3240



agccgggccg gggtcatgtc tgaccgaagc tggttccagg atggcagagc caggacagta     3300



tctgaccatc gctgcttcca gtcctgccag gcacacgctt gcagcgtctg ccactccctg     3360



agctccagga tcgggagccc gcccagcgtg gtgatgctag tgggctccag ccctcgcacc     3420



tgtcatacct gtggacgcac acagcccacc cgtgtggtgc agggcatggg ccagggcact     3480



gagggccccg gggcagtgtc ttgggcctcc gcctaccagc tggctgccct gagtcccagg     3540



cagccgcatc gccaggacaa agcggccaca gccatccagt ccgcctggag gggctttaag     3600



atccgccagc agatgaggca gcagcaaatg gcagcgaaga tagttcaagc cacctggcga     3660



ggccaccata cccggagctg tctgaagaac acagaggcgc tcttgggacc agcagacccc     3720



tcggccagct cacggcacat gcattggcct ggcatctagg accctggctc cctgcagtgg     3780



ggacttcgtg ggaggcactc atggctctct gggtctaatg aataaagtcc tccacagcct     3840



agaaaaaaaa aaaaaaaaaa                                                 3860





<210>  131

<211>  1180

<212>  PRT

<213>  Homo sapiens



<400>  131



Met Thr Leu Gln Gly Arg Ala Asp Leu Ser Gly Asn Gln Gly Asn Ala 

1               5                   10                  15      





Ala Gly Arg Leu Ala Thr Val His Glu Pro Val Val Thr Gln Trp Ala 

            20                  25                  30          





Val His Pro Pro Ala Pro Ala His Pro Ser Leu Leu Asp Lys Met Glu 

        35                  40                  45              





Lys Ala Pro Pro Gln Pro Gln His Glu Gly Leu Lys Ser Lys Glu His 

    50                  55                  60                  





Leu Pro Gln Gln Pro Ala Glu Gly Lys Thr Ala Ser Arg Arg Val Pro 

65                  70                  75                  80  





Arg Leu Arg Ala Val Val Glu Ser Gln Ala Phe Lys Asn Ile Leu Val 

                85                  90                  95      





Asp Glu Met Asp Met Met His Ala Arg Ala Ala Thr Leu Ile Gln Ala 

            100                 105                 110         





Asn Trp Arg Gly Tyr Trp Leu Arg Gln Lys Leu Ile Ser Gln Met Met 

        115                 120                 125             





Ala Ala Lys Ala Ile Gln Glu Ala Trp Arg Arg Phe Asn Lys Arg His 

    130                 135                 140                 





Ile Leu His Ser Ser Lys Ser Leu Val Lys Lys Thr Arg Ala Glu Glu 

145                 150                 155                 160 





Gly Asp Ile Pro Tyr His Ala Pro Gln Gln Val Arg Phe Gln His Pro 

                165                 170                 175     





Glu Glu Asn Arg Leu Leu Ser Pro Pro Ile Met Val Asn Lys Glu Thr 

            180                 185                 190         





Gln Phe Pro Ser Cys Asp Asn Leu Val Leu Cys Arg Pro Gln Ser Ser 

        195                 200                 205             





Pro Leu Leu Gln Pro Pro Ala Ala Gln Gly Thr Pro Glu Pro Cys Val 

    210                 215                 220                 





Gln Gly Pro His Ala Ala Arg Val Arg Gly Leu Ala Phe Leu Pro His 

225                 230                 235                 240 





Gln Thr Val Thr Ile Arg Phe Pro Cys Pro Val Ser Leu Asp Ala Lys 

                245                 250                 255     





Cys Gln Pro Cys Leu Leu Thr Arg Thr Ile Arg Ser Thr Cys Leu Val 

            260                 265                 270         





His Ile Glu Gly Asp Ser Val Lys Thr Lys Arg Val Ser Ala Arg Thr 

        275                 280                 285             





Asn Lys Ala Arg Ala Pro Glu Thr Pro Leu Ser Arg Arg Tyr Asp Gln 

    290                 295                 300                 





Ala Val Thr Arg Pro Ser Arg Ala Gln Thr Gln Gly Pro Val Lys Ala 

305                 310                 315                 320 





Glu Thr Pro Lys Ala Pro Phe Gln Ile Cys Pro Gly Pro Met Ile Thr 

                325                 330                 335     





Lys Thr Leu Leu Gln Thr Tyr Pro Val Val Ser Val Thr Leu Pro Gln 

            340                 345                 350         





Thr Tyr Pro Ala Ser Thr Met Thr Thr Thr Pro Pro Lys Thr Ser Pro 

        355                 360                 365             





Val Pro Lys Val Thr Ile Ile Lys Thr Pro Ala Gln Met Tyr Pro Gly 

    370                 375                 380                 





Pro Thr Val Thr Lys Thr Ala Pro His Thr Cys Pro Met Pro Thr Met 

385                 390                 395                 400 





Thr Lys Ile Gln Val His Pro Thr Ala Ser Arg Thr Gly Thr Pro Arg 

                405                 410                 415     





Gln Thr Cys Pro Ala Thr Ile Thr Ala Lys Asn Arg Pro Gln Val Ser 

            420                 425                 430         





Leu Leu Ala Ser Ile Met Lys Ser Leu Pro Gln Val Cys Pro Gly Pro 

        435                 440                 445             





Ala Met Ala Lys Thr Pro Pro Gln Met His Pro Val Thr Thr Pro Ala 

    450                 455                 460                 





Lys Asn Pro Leu Gln Thr Cys Leu Ser Ala Thr Met Ser Lys Thr Ser 

465                 470                 475                 480 





Ser Gln Arg Ser Pro Val Gly Val Thr Lys Pro Ser Pro Gln Thr Arg 

                485                 490                 495     





Leu Pro Ala Met Ile Thr Lys Thr Pro Ala Gln Leu Arg Ser Val Ala 

            500                 505                 510         





Thr Ile Leu Lys Thr Leu Cys Leu Ala Ser Pro Thr Val Ala Asn Val 

        515                 520                 525             





Lys Ala Pro Pro Gln Val Ala Val Ala Ala Gly Thr Pro Asn Thr Ser 

    530                 535                 540                 





Gly Ser Ile His Glu Asn Pro Pro Lys Ala Lys Ala Thr Val Asn Val 

545                 550                 555                 560 





Lys Gln Ala Ala Lys Val Val Lys Ala Ser Ser Pro Ser Tyr Leu Ala 

                565                 570                 575     





Glu Gly Lys Ile Arg Cys Leu Ala Gln Pro His Pro Gly Thr Gly Val 

            580                 585                 590         





Pro Arg Ala Ala Ala Glu Leu Pro Leu Glu Ala Glu Lys Ile Lys Thr 

        595                 600                 605             





Gly Thr Gln Lys Gln Ala Lys Thr Asp Met Ala Phe Lys Thr Ser Val 

    610                 615                 620                 





Ala Val Glu Met Ala Gly Ala Pro Ser Trp Thr Lys Val Ala Glu Glu 

625                 630                 635                 640 





Gly Asp Lys Pro Pro His Val Tyr Val Pro Val Asp Met Ala Val Thr 

                645                 650                 655     





Leu Pro Arg Gly Gln Leu Ala Ala Pro Leu Thr Asn Ala Ser Ser Gln 

            660                 665                 670         





Arg His Pro Pro Cys Leu Ser Gln Arg Pro Leu Ala Ala Pro Leu Thr 

        675                 680                 685             





Lys Ala Ser Ser Gln Gly His Leu Pro Thr Glu Leu Thr Lys Thr Pro 

    690                 695                 700                 





Ser Leu Ala His Leu Asp Thr Cys Leu Ser Lys Met His Ser Gln Thr 

705                 710                 715                 720 





His Leu Ala Thr Gly Ala Val Lys Val Gln Ser Gln Ala Pro Leu Ala 

                725                 730                 735     





Thr Cys Leu Thr Lys Thr Gln Ser Arg Gly Gln Pro Ile Thr Asp Ile 

            740                 745                 750         





Thr Thr Cys Leu Ile Pro Ala His Gln Ala Ala Asp Leu Ser Ser Asn 

        755                 760                 765             





Thr His Ser Gln Val Leu Leu Thr Gly Ser Lys Val Ser Asn His Ala 

    770                 775                 780                 





Cys Gln Arg Leu Gly Gly Leu Ser Ala Pro Pro Trp Ala Lys Pro Glu 

785                 790                 795                 800 





Asp Arg Gln Thr Gln Pro Gln Pro His Gly His Val Pro Gly Lys Thr 

                805                 810                 815     





Thr Gln Gly Gly Pro Cys Pro Ala Ala Cys Glu Val Gln Gly Met Leu 

            820                 825                 830         





Val Pro Pro Met Ala Pro Thr Gly His Ser Thr Cys Asn Val Glu Ser 

        835                 840                 845             





Trp Gly Asp Asn Gly Ala Thr Arg Ala Gln Pro Ser Met Pro Gly Gln 

    850                 855                 860                 





Ala Val Pro Cys Gln Glu Asp Thr Gly Pro Ala Asp Ala Gly Val Val 

865                 870                 875                 880 





Gly Gly Gln Ser Trp Asn Arg Ala Trp Glu Pro Ala Arg Gly Ala Ala 

                885                 890                 895     





Ser Trp Asp Thr Trp Arg Asn Lys Ala Val Val Pro Pro Arg Arg Ser 

            900                 905                 910         





Gly Glu Pro Met Val Ser Met Gln Ala Ala Glu Glu Ile Arg Ile Leu 

        915                 920                 925             





Ala Val Ile Thr Ile Gln Ala Gly Val Arg Gly Tyr Leu Ala Arg Arg 

    930                 935                 940                 





Arg Ile Arg Leu Trp His Arg Gly Ala Met Val Ile Gln Ala Thr Trp 

945                 950                 955                 960 





Arg Gly Tyr Arg Val Arg Arg Asn Leu Ala His Leu Cys Arg Ala Thr 

                965                 970                 975     





Thr Thr Ile Gln Ser Ala Trp Arg Gly Tyr Ser Thr Arg Arg Asp Gln 

            980                 985                 990         





Ala Arg His Trp Gln Met Leu His  Pro Val Thr Trp Val  Glu Leu Gly 

        995                 1000                 1005             





Ser Arg  Ala Gly Val Met Ser  Asp Arg Ser Trp Phe  Gln Asp Gly 

    1010                 1015                 1020             





Arg Ala  Arg Thr Val Ser Asp  His Arg Cys Phe Gln  Ser Cys Gln 

    1025                 1030                 1035             





Ala His  Ala Cys Ser Val Cys  His Ser Leu Ser Ser  Arg Ile Gly 

    1040                 1045                 1050             





Ser Pro  Pro Ser Val Val Met  Leu Val Gly Ser Ser  Pro Arg Thr 

    1055                 1060                 1065             





Cys His  Thr Cys Gly Arg Thr  Gln Pro Thr Arg Val  Val Gln Gly 

    1070                 1075                 1080             





Met Gly  Gln Gly Thr Glu Gly  Pro Gly Ala Val Ser  Trp Ala Ser 

    1085                 1090                 1095             





Ala Tyr  Gln Leu Ala Ala Leu  Ser Pro Arg Gln Pro  His Arg Gln 

    1100                 1105                 1110             





Asp Lys  Ala Ala Thr Ala Ile  Gln Ser Ala Trp Arg  Gly Phe Lys 

    1115                 1120                 1125             





Ile Arg  Gln Gln Met Arg Gln  Gln Gln Met Ala Ala  Lys Ile Val 

    1130                 1135                 1140             





Gln Ala  Thr Trp Arg Gly His  His Thr Arg Ser Cys  Leu Lys Asn 

    1145                 1150                 1155             





Thr Glu  Ala Leu Leu Gly Pro  Ala Asp Pro Ser Ala  Ser Ser Arg 

    1160                 1165                 1170             





His Met  His Trp Pro Gly Ile  

    1175                 1180 





<210>  132

<211>  613

<212>  DNA

<213>  Homo sapiens



<400>  132

tctccttttt ttccagcccc ggccccagac gctacagccg ccgaaatgtt gatgcctaag       60



aagaaccgga ttgccattta tgaactcctt tttaaggagg gagccatggt ggccaagaag      120



gatgtccaca cgcctaagca gccggagttg gcagacaaga atgtgcccaa ccttcatgtc      180



atgaaggcca tgcagtctct gaagtcccga ggctacatga aggaacagtt tgcctggaga      240



catttctact ggtaccttac caatgagggt atccaccatc tccgtgatta ccttcatctg      300



cccccggaga ttgtgcctgc caccctatgc cacagccgtc cagagactgg caggcctggg      360



cctaaaggtc tggagggtga gtgacctgca agactcacaa gaggggaagc caacagagat      420



acctacagat ggaatgctgt gcttcctggt gctgacaaga aagccgatgc tgggagtggg      480



tcagcaaccg aattccagtt tagaggcaga tttggtcgtg gacatggtca gccatctcag      540



taaaattgga gaggattatt ttgcattgaa taaacttaca gccaaaaaaa aaaaagtcaa      600



acagaataat atg                                                         613





<210>  133

<211>  1321

<212>  DNA

<213>  Homo sapiens



<400>  133

tcagccgaag tgctgggatt acagacctga gccactgcgc ccagccttga tcttgaggtt       60



tcctgggaga aggtggctta aggctgagac acttatgccc tgggccagcc actggattcc      120



tgtgctctgc ttcactccta gttaccagaa aggtggaatc tggatgagtg gaggccccag      180



cggaaaggcg cagatacccg gagacttccc agagagactc gacccaccaa aaagcgcacc      240



gcggccgcgc agcccttcct tcagctctgg aacccagcgc cccacacctc aaatgggaga      300



actggtgacc tctagtggcc catgaccagc ctgcagggcc tggggctggc ggggattctc      360



tgacccaaac tctcctgggc tctaatgctg ttcccctgcc caccctacct tctgccttca      420



cactgctgag gggtccgtag ccgacaagga agagctcatt tctcatttgt catgaccatc      480



tttaataaaa aataaattag ttctgggtgg gaaccatatc aggaggcagg gagtggggct      540



aggggctggg cggggttggg gggggagcgc atgctcacat ttctcttttt caccctctgc      600



ccagctgggc cttgctctgg agaggcagtc tctttcctcc tgccttcctg ggtaaggcag      660



gattggcagt ggctgacccc agccctagct aattagggag gcaggggcag agatactagg      720



caaatgagaa ggggtcagag acacagggca gcttagaaga tgtgaggtct gaacatgaga      780



aatgaggctt agggcacaaa actggagttg gtggggagac cacactctaa gtagctcaga      840



ttagcaagga actgcagact tgctttcctc tccacctagg aaagtctcag ggaaacaggt      900



cttgtccttc tcagtctgtg taacctcttt ttgaaaagtg atacacgttt gagcacacac      960



atatccatgc agtcccaaaa gcacacctga ggcatatgtg cacacaccca tcacaccacc     1020



acatgggcct gaccacagcc ctgaaagtca ctttctgtca gtcaccttgc caccctctgt     1080



cacctggagg acatccctgc tgagactggg acaggctgga gagccagggg gttcagagtg     1140



ggccgatcaa tgggtgaccg atggtggcac agaaaaccgt gaaggtgccc cggacccctt     1200



tcaggaggga tcctggggag accgctccag gacatgtgcg caagagcggc aacaggtggc     1260



tgtgtagtag gggtagacgc agagccgggc ctgtaccacc agggggcaat gtggagagct     1320



g                                                                     1321





<210>  134

<211>  76

<212>  PRT

<213>  Homo sapiens



<400>  134



Met Pro Trp Ala Ser His Trp Ile Pro Val Leu Cys Phe Thr Pro Ser 

1               5                   10                  15      





Tyr Gln Lys Gly Gly Ile Trp Met Ser Gly Gly Pro Ser Gly Lys Ala 

            20                  25                  30          





Gln Ile Pro Gly Asp Phe Pro Glu Arg Leu Asp Pro Pro Lys Ser Ala 

        35                  40                  45              





Pro Arg Pro Arg Ser Pro Ser Phe Ser Ser Gly Thr Gln Arg Pro Thr 

    50                  55                  60                  





Pro Gln Met Gly Glu Leu Val Thr Ser Ser Gly Pro 

65                  70                  75      





<210>  135

<211>  417

<212>  DNA

<213>  Homo sapiens



<400>  135

atgaatgagt tgcgaaaaaa gcaactacac aaattcaatg agagaaaggg aggagtcctg       60



actcatactt tctctactca acctcccggc ccaccccacc ccccaggggt cccggcgcca      120



tttagctcct ccgaagccgc cgccattttc cgcccccgcc ggatcgctgc tgtgcctcgg      180



cagccgctcg cttccctact ctgcagcctc agccacgggc tccgcccggc cctaagaggg      240



aggccctggc cggaacgtgc ggggacggca gctgcaacgt caggaaggcc aggccccgac      300



cccgcccgca gtgccccggc gccgacagct tgcgccagcc ggcgggagct agcgggcagc      360



aagggggccg gacaggctcc actgggcgga gcggcccggg cggcggttgg aacctga         417





<210>  136

<211>  138

<212>  PRT

<213>  Homo sapiens



<400>  136



Met Asn Glu Leu Arg Lys Lys Gln Leu His Lys Phe Asn Glu Arg Lys 

1               5                   10                  15      





Gly Gly Val Leu Thr His Thr Phe Ser Thr Gln Pro Pro Gly Pro Pro 

            20                  25                  30          





His Pro Pro Gly Val Pro Ala Pro Phe Ser Ser Ser Glu Ala Ala Ala 

        35                  40                  45              





Ile Phe Arg Pro Arg Arg Ile Ala Ala Val Pro Arg Gln Pro Leu Ala 

    50                  55                  60                  





Ser Leu Leu Cys Ser Leu Ser His Gly Leu Arg Pro Ala Leu Arg Gly 

65                  70                  75                  80  





Arg Pro Trp Pro Glu Arg Ala Gly Thr Ala Ala Ala Thr Ser Gly Arg 

                85                  90                  95      





Pro Gly Pro Asp Pro Ala Arg Ser Ala Pro Ala Pro Thr Ala Cys Ala 

            100                 105                 110         





Ser Arg Arg Glu Leu Ala Gly Ser Lys Gly Ala Gly Gln Ala Pro Leu 

        115                 120                 125             





Gly Gly Ala Ala Arg Ala Ala Val Gly Thr 

    130                 135             





<210>  137

<211>  1500

<212>  DNA

<213>  Homo sapiens



<400>  137

gccgagcccg ggcccagcgc cgcctgcagc ctcgggaagg gagcggatag cggagccccg       60



agccgcccgc agagcaagcg cggggaacca aggagacgct cctggcactg cagataactt      120



gtctgcattt caagaacaac ctaccagaga ccttacctgt caccttggct ctcccaccca      180



atggagatgg ctctaatggt ggcacaaacc aggaagggga aatctgtggt ttaaattctt      240



tatgcctcat cctctgagtg ctgaaggctt gctgtaggct gtatgctgtt aatgctaatc      300



gtgatagggg tttttgcctc caactgactc ctacatatta gcattaacag tgtatgatgc      360



ctgttactag cattcacatg gaacaaattg ctgccgtggg aggatgacaa agaagcatga      420



gtcaccctgc tggataaact tagacttcag gctttatcat ttttcaatct gttaatcata      480



atctggtcac tgggatgttc aaccttaaac taagttttga aagtaaggtt atttaaaaga      540



tttatcagta gtatcctaaa tgcaaacatt ttcatttaaa tgtcaagccc atgtttgttt      600



ttatcattaa cagaaaatat attcatgtca ttcttaattg caggttttgg cttgttcatt      660



ataatgttca taaacacctt tgattcaact gttagaaatg tgggctaaac acaaatttct      720



ataatatttt tgtagttaaa aattagaagg actactaacc tccagttata tcatggattg      780



tctggcaacg ttttttaaaa gatttagaaa ctggtacttt cccccaggta acgattttct      840



gttcaggcaa cttcagttta aaattaatac ttttatttga ctcttaaagg gaaactgaaa      900



ggctatgaag ctgaattttt ttaatgaaat atttttaaca gttagcaggg taaataacat      960



ctgacagcta atgagatatt ttttccatac aagataaaaa gatttaatca aaaaatttca     1020



tatttgaaat gaagtcccaa atctaggttc aagttcaata gcttagccac ataatacggt     1080



tgtgcgagca gagaatctac ctttccactt ctaagcctgt ttcttcctcc atatggggat     1140



aatactttac aaggttgttg tgaggcttag atgagataga gaattattcc ataagataat     1200



caagtgctac attaatgtta tagttagatt aatccaagaa ctagtcaccc tactttatta     1260



gagaagagaa aagctaatga tttgatttgc agaatattta aggtttggat ttctatgcag     1320



tttttctaaa taaccatcac ttacaaatat gtaaccaaac gtaattgtta gtatatttaa     1380



tgtaaacttg ttttaacaac tcttctcaac attttgtcca ggttattcac tgtaaccaaa     1440



taaatctcat gagtctttag ttgatttaaa ataaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500





<210>  138

<211>  72

<212>  DNA

<213>  Homo sapiens



<400>  138

tgtcgggtag cttatcagac tgatgttgac tgttgaatct catggcaaca ccagtcgatg       60



ggctgtctga ca                                                           72





<210>  139

<211>  85

<212>  DNA

<213>  Homo sapiens



<400>  139

ggctgagccg cagtagttct tcagtggcaa gctttatgtc ctgacccagc taaagctgcc       60



agttgaagaa ctgttgccct ctgcc                                             85





<210>  140

<211>  2800

<212>  DNA

<213>  Homo sapiens



<400>  140

acatccgggt accgactcca gccgcctaga cgctggcact atggtcatgg cggaggggac       60



ggcagtgctg aggcggaaca ggccgggcac caaggcgcag tatattcaac agaacataag      120



agcagattgc tccaatattg acaaaattct tgaaccacct gaaggccaag atgaaggtgt      180



gtggaagtat gaacatttaa ggcagttctg ccttgagcta aatggacttg ctgtcaaact      240



tcagagtgaa tgccatccag atacttgcac tcaaatgaca gcaactgaac aatggatttt      300



tctttgtgca gctcataaaa ctccaaaaga gtgtcctgct atagactata ctagacacac      360



acttgatggt gctgcatgtc ttctgaatag caataaatat tttcccagca gggttagcat      420



aaaggaatca tctgtagcga aactaggatc agtatgccgt aggatttaca gaatattttc      480



acatgcttat tttcatcatc ggcagatatt tgatgaatat gaaaatgaaa catttttgtg      540



tcatcggttt actaagtttg tgatgaaata caatttgatg tccaaggata acctgattgt      600



accaatttta gaagaggaag tacagaattc agtttctggg gaaagtgaag catgaaggga      660



atcataggaa aaatgtactg atcatataat taacattatg tactgtatat atcattttag      720



acacatcaat catgtatcca tattatagct tctttgttta gtataggttt ttgtatgctg      780



ggtttgcctt ttaaaatggg aaatactttt taagttattc ataagctgta tattcaccag      840



tgtggcactc atggttttta aataagatta gtattatctg tttataatgc ctgttaataa      900



aagaatttac agtttggtaa aattgctgct aaacaatcat tggatcacaa tcctcatcag      960



acaaacccat ctgtaaaaaa aatgagggag agcttgaggt ttcacacaag ccatttacta     1020



aagaggtaga aatgttttct attggtttta ccttgagttt agatatccta aaaaattctg     1080



tagtacgtag ttttgtctta cctgttaact ttccccaatt gagataaaag tgttttaaaa     1140



ttctgtttat agtttttgat atgcatatat aattatgtgt atatctaaat acaaatgcaa     1200



atgaagcatt agtaatactt aaataatttt actgtgctac ataaagtata acatacttgg     1260



aaaggattta ccgttctgca acaacggact ggtacataca ggatgatcac aatggtaagg     1320



cacataaatt attttcccac tggaaacctg ccctgtccac cccttctcat ttcccttaac     1380



cttatcttca aactacttta gctgagaagc ttttcaccag actgagttag tggtggctta     1440



tacctattta tatttgtatt aattgcttac agattatacc tcatattagc aattacatta     1500



cactacaaga aaatgtattt gcataggctc ttgcttatct ttgttttgca aaattgttct     1560



acttagaaaa cagtccttaa aatagtttga ctcttcctgt tagtaatata ttaatctttc     1620



atttaaccag ctaggcagca ttaaatagaa ttgaagaaat accatagtat ttattttaca     1680



ccccctctcc cacgaagttt atgtttggat tacatgcacg tgtgagatta tttgcaataa     1740



ttcataggtt ccaagggtgt tgatgaatag tcatacattt ttttggactt tgttataatt     1800



cattgtggta agaatgattg aaatgcagat ttaacaatct tataatctat tgaatgccat     1860



ttttgataaa gcactggagg tcttattgcc aaactgattg taatgaggca gtaagggtga     1920



aaacattgta catgttgtga agaaagtatt taaatccaac ttttgaacag atttaacaaa     1980



catgaggaac ttttttattt agaaggataa ttttgaagat gaaaatgtat tcatcttaat     2040



tgttttttca aatttaaggg aataatttat accatctttt cagacaagaa tgtacagcaa     2100



aaataagggg aacagtagta tactgagagt gtgtgtatgt atagtgtatg cctttccaag     2160



cttgccagtc tttttggctt tgaacactgc ccatcagcta cagtcattac tgttccccaa     2220



cccacaacta tcttttaaga agtcttagtt cacagtgaaa ggaatgatga ctttgaaatt     2280



atggatttat attaatggca ctataaacca atggtaatgg taatttttaa acttgctaaa     2340



tattgagaaa ctaaactact aagttaataa attatatata gcagtgtagc tgttctctct     2400



agatggtgtc tcacaatgga tttctgttgc ttgactattt tcttagtgaa tatttatact     2460



aaggtagtga ctgagatttg gtgatctggc tgagtatttt gaaacacatt ttgaataata     2520



tggcttagtg ttaacgggga cttaaatatg attttttttt cttactcatt tcaccttccc     2580



tgtactgtat gtttggaatt gatcataaaa catctccaaa agaaaataat cagtttgtag     2640



tcttgctttt gtattcatgt tgataatctt actaattgtg aagttgattc actactatac     2700



taggtaagac ctaagtgaaa cagttcctgt ttttccttaa tactgttttc agaattttga     2760



aaatgtactt atatatacat aaatactact aaaaaattaa                           2800





<210>  141

<211>  204

<212>  PRT

<213>  Homo sapiens



<400>  141



Met Val Met Ala Glu Gly Thr Ala Val Leu Arg Arg Asn Arg Pro Gly 

1               5                   10                  15      





Thr Lys Ala Gln Tyr Ile Gln Gln Asn Ile Arg Ala Asp Cys Ser Asn 

            20                  25                  30          





Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln Asp Glu Gly Val Trp 

        35                  40                  45              





Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu Leu Asn Gly Leu Ala 

    50                  55                  60                  





Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr Cys Thr Gln Met Thr 

65                  70                  75                  80  





Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala His Lys Thr Pro Lys 

                85                  90                  95      





Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr Leu Asp Gly Ala Ala 

            100                 105                 110         





Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser Arg Val Ser Ile Lys 

        115                 120                 125             





Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys Arg Arg Ile Tyr Arg 

    130                 135                 140                 





Ile Phe Ser His Ala Tyr Phe His His Arg Gln Ile Phe Asp Glu Tyr 

145                 150                 155                 160 





Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr Lys Phe Val Met Lys 

                165                 170                 175     





Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val Pro Ile Leu Glu Glu 

            180                 185                 190         





Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu Ala 

        195                 200                 





<210>  142

<211>  2863

<212>  DNA

<213>  Homo sapiens



<400>  142

acatccgggt accgactcca gccgcctaga cgctggcact atggtcatgg cggaggggac       60



ggcagtgctg aggcggaaca ggccgggcac caaggcgcag gatttctata attggcctga      120



tgaatccttt gatgaaatgg acagtacact agctgttcaa cagtatattc aacagaacat      180



aagagcagat tgctccaata ttgacaaaat tcttgaacca cctgaaggcc aagatgaagg      240



tgtgtggaag tatgaacatt taaggcagtt ctgccttgag ctaaatggac ttgctgtcaa      300



acttcagagt gaatgccatc cagatacttg cactcaaatg acagcaactg aacaatggat      360



ttttctttgt gcagctcata aaactccaaa agagtgtcct gctatagact atactagaca      420



cacacttgat ggtgctgcat gtcttctgaa tagcaataaa tattttccca gcagggttag      480



cataaaggaa tcatctgtag cgaaactagg atcagtatgc cgtaggattt acagaatatt      540



ttcacatgct tattttcatc atcggcagat atttgatgaa tatgaaaatg aaacattttt      600



gtgtcatcgg tttactaagt ttgtgatgaa atacaatttg atgtccaagg ataacctgat      660



tgtaccaatt ttagaagagg aagtacagaa ttcagtttct ggggaaagtg aagcatgaag      720



ggaatcatag gaaaaatgta ctgatcatat aattaacatt atgtactgta tatatcattt      780



tagacacatc aatcatgtat ccatattata gcttctttgt ttagtatagg tttttgtatg      840



ctgggtttgc cttttaaaat gggaaatact ttttaagtta ttcataagct gtatattcac      900



cagtgtggca ctcatggttt ttaaataaga ttagtattat ctgtttataa tgcctgttaa      960



taaaagaatt tacagtttgg taaaattgct gctaaacaat cattggatca caatcctcat     1020



cagacaaacc catctgtaaa aaaaatgagg gagagcttga ggtttcacac aagccattta     1080



ctaaagaggt agaaatgttt tctattggtt ttaccttgag tttagatatc ctaaaaaatt     1140



ctgtagtacg tagttttgtc ttacctgtta actttcccca attgagataa aagtgtttta     1200



aaattctgtt tatagttttt gatatgcata tataattatg tgtatatcta aatacaaatg     1260



caaatgaagc attagtaata cttaaataat tttactgtgc tacataaagt ataacatact     1320



tggaaaggat ttaccgttct gcaacaacgg actggtacat acaggatgat cacaatggta     1380



aggcacataa attattttcc cactggaaac ctgccctgtc caccccttct catttccctt     1440



aaccttatct tcaaactact ttagctgaga agcttttcac cagactgagt tagtggtggc     1500



ttatacctat ttatatttgt attaattgct tacagattat acctcatatt agcaattaca     1560



ttacactaca agaaaatgta tttgcatagg ctcttgctta tctttgtttt gcaaaattgt     1620



tctacttaga aaacagtcct taaaatagtt tgactcttcc tgttagtaat atattaatct     1680



ttcatttaac cagctaggca gcattaaata gaattgaaga aataccatag tatttatttt     1740



acaccccctc tcccacgaag tttatgtttg gattacatgc acgtgtgaga ttatttgcaa     1800



taattcatag gttccaaggg tgttgatgaa tagtcataca tttttttgga ctttgttata     1860



attcattgtg gtaagaatga ttgaaatgca gatttaacaa tcttataatc tattgaatgc     1920



catttttgat aaagcactgg aggtcttatt gccaaactga ttgtaatgag gcagtaaggg     1980



tgaaaacatt gtacatgttg tgaagaaagt atttaaatcc aacttttgaa cagatttaac     2040



aaacatgagg aactttttta tttagaagga taattttgaa gatgaaaatg tattcatctt     2100



aattgttttt tcaaatttaa gggaataatt tataccatct tttcagacaa gaatgtacag     2160



caaaaataag gggaacagta gtatactgag agtgtgtgta tgtatagtgt atgcctttcc     2220



aagcttgcca gtctttttgg ctttgaacac tgcccatcag ctacagtcat tactgttccc     2280



caacccacaa ctatctttta agaagtctta gttcacagtg aaaggaatga tgactttgaa     2340



attatggatt tatattaatg gcactataaa ccaatggtaa tggtaatttt taaacttgct     2400



aaatattgag aaactaaact actaagttaa taaattatat atagcagtgt agctgttctc     2460



tctagatggt gtctcacaat ggatttctgt tgcttgacta ttttcttagt gaatatttat     2520



actaaggtag tgactgagat ttggtgatct ggctgagtat tttgaaacac attttgaata     2580



atatggctta gtgttaacgg ggacttaaat atgatttttt tttcttactc atttcacctt     2640



ccctgtactg tatgtttgga attgatcata aaacatctcc aaaagaaaat aatcagtttg     2700



tagtcttgct tttgtattca tgttgataat cttactaatt gtgaagttga ttcactacta     2760



tactaggtaa gacctaagtg aaacagttcc tgtttttcct taatactgtt ttcagaattt     2820



tgaaaatgta cttatatata cataaatact actaaaaaat taa                       2863





<210>  143

<211>  225

<212>  PRT

<213>  Homo sapiens



<400>  143



Met Val Met Ala Glu Gly Thr Ala Val Leu Arg Arg Asn Arg Pro Gly 

1               5                   10                  15      





Thr Lys Ala Gln Asp Phe Tyr Asn Trp Pro Asp Glu Ser Phe Asp Glu 

            20                  25                  30          





Met Asp Ser Thr Leu Ala Val Gln Gln Tyr Ile Gln Gln Asn Ile Arg 

        35                  40                  45              





Ala Asp Cys Ser Asn Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln 

    50                  55                  60                  





Asp Glu Gly Val Trp Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu 

65                  70                  75                  80  





Leu Asn Gly Leu Ala Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr 

                85                  90                  95      





Cys Thr Gln Met Thr Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala 

            100                 105                 110         





His Lys Thr Pro Lys Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr 

        115                 120                 125             





Leu Asp Gly Ala Ala Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser 

    130                 135                 140                 





Arg Val Ser Ile Lys Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys 

145                 150                 155                 160 





Arg Arg Ile Tyr Arg Ile Phe Ser His Ala Tyr Phe His His Arg Gln 

                165                 170                 175     





Ile Phe Asp Glu Tyr Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr 

            180                 185                 190         





Lys Phe Val Met Lys Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val 

        195                 200                 205             





Pro Ile Leu Glu Glu Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu 

    210                 215                 220                 





Ala 

225 





<210>  144

<211>  2852

<212>  DNA

<213>  Homo sapiens



<400>  144

atttgccaag actgctggcc tgttttctac cctgattcct taggtggctt ctgggacaga       60



attacggttc tctaagtatt tgcttgcagg atttctataa ttggcctgat gaatcctttg      120



atgaaatgga cagtacacta gctgttcaac agtatattca acagaacata agagcagatt      180



gctccaatat tgacaaaatt cttgaaccac ctgaaggcca agatgaaggt gtgtggaagt      240



atgaacattt aaggcagttc tgccttgagc taaatggact tgctgtcaaa cttcagagtg      300



aatgccatcc agatacttgc actcaaatga cagcaactga acaatggatt tttctttgtg      360



cagctcataa aactccaaaa gagtgtcctg ctatagacta tactagacac acacttgatg      420



gtgctgcatg tcttctgaat agcaataaat attttcccag cagggttagc ataaaggaat      480



catctgtagc gaaactagga tcagtatgcc gtaggattta cagaatattt tcacatgctt      540



attttcatca tcggcagata tttgatgaat atgaaaatga aacatttttg tgtcatcggt      600



ttactaagtt tgtgatgaaa tacaatttga tgtccaagga taacctgatt gtaccaattt      660



tagaagagga agtacagaat tcagtttctg gggaaagtga agcatgaagg gaatcatagg      720



aaaaatgtac tgatcatata attaacatta tgtactgtat atatcatttt agacacatca      780



atcatgtatc catattatag cttctttgtt tagtataggt ttttgtatgc tgggtttgcc      840



ttttaaaatg ggaaatactt tttaagttat tcataagctg tatattcacc agtgtggcac      900



tcatggtttt taaataagat tagtattatc tgtttataat gcctgttaat aaaagaattt      960



acagtttggt aaaattgctg ctaaacaatc attggatcac aatcctcatc agacaaaccc     1020



atctgtaaaa aaaatgaggg agagcttgag gtttcacaca agccatttac taaagaggta     1080



gaaatgtttt ctattggttt taccttgagt ttagatatcc taaaaaattc tgtagtacgt     1140



agttttgtct tacctgttaa ctttccccaa ttgagataaa agtgttttaa aattctgttt     1200



atagtttttg atatgcatat ataattatgt gtatatctaa atacaaatgc aaatgaagca     1260



ttagtaatac ttaaataatt ttactgtgct acataaagta taacatactt ggaaaggatt     1320



taccgttctg caacaacgga ctggtacata caggatgatc acaatggtaa ggcacataaa     1380



ttattttccc actggaaacc tgccctgtcc accccttctc atttccctta accttatctt     1440



caaactactt tagctgagaa gcttttcacc agactgagtt agtggtggct tatacctatt     1500



tatatttgta ttaattgctt acagattata cctcatatta gcaattacat tacactacaa     1560



gaaaatgtat ttgcataggc tcttgcttat ctttgttttg caaaattgtt ctacttagaa     1620



aacagtcctt aaaatagttt gactcttcct gttagtaata tattaatctt tcatttaacc     1680



agctaggcag cattaaatag aattgaagaa ataccatagt atttatttta caccccctct     1740



cccacgaagt ttatgtttgg attacatgca cgtgtgagat tatttgcaat aattcatagg     1800



ttccaagggt gttgatgaat agtcatacat ttttttggac tttgttataa ttcattgtgg     1860



taagaatgat tgaaatgcag atttaacaat cttataatct attgaatgcc atttttgata     1920



aagcactgga ggtcttattg ccaaactgat tgtaatgagg cagtaagggt gaaaacattg     1980



tacatgttgt gaagaaagta tttaaatcca acttttgaac agatttaaca aacatgagga     2040



acttttttat ttagaaggat aattttgaag atgaaaatgt attcatctta attgtttttt     2100



caaatttaag ggaataattt ataccatctt ttcagacaag aatgtacagc aaaaataagg     2160



ggaacagtag tatactgaga gtgtgtgtat gtatagtgta tgcctttcca agcttgccag     2220



tctttttggc tttgaacact gcccatcagc tacagtcatt actgttcccc aacccacaac     2280



tatcttttaa gaagtcttag ttcacagtga aaggaatgat gactttgaaa ttatggattt     2340



atattaatgg cactataaac caatggtaat ggtaattttt aaacttgcta aatattgaga     2400



aactaaacta ctaagttaat aaattatata tagcagtgta gctgttctct ctagatggtg     2460



tctcacaatg gatttctgtt gcttgactat tttcttagtg aatatttata ctaaggtagt     2520



gactgagatt tggtgatctg gctgagtatt ttgaaacaca ttttgaataa tatggcttag     2580



tgttaacggg gacttaaata tgattttttt ttcttactca tttcaccttc cctgtactgt     2640



atgtttggaa ttgatcataa aacatctcca aaagaaaata atcagtttgt agtcttgctt     2700



ttgtattcat gttgataatc ttactaattg tgaagttgat tcactactat actaggtaag     2760



acctaagtga aacagttcct gtttttcctt aatactgttt tcagaatttt gaaaatgtac     2820



ttatatatac ataaatacta ctaaaaaatt aa                                   2852





<210>  145

<211>  193

<212>  PRT

<213>  Homo sapiens



<400>  145



Met Asp Ser Thr Leu Ala Val Gln Gln Tyr Ile Gln Gln Asn Ile Arg 

1               5                   10                  15      





Ala Asp Cys Ser Asn Ile Asp Lys Ile Leu Glu Pro Pro Glu Gly Gln 

            20                  25                  30          





Asp Glu Gly Val Trp Lys Tyr Glu His Leu Arg Gln Phe Cys Leu Glu 

        35                  40                  45              





Leu Asn Gly Leu Ala Val Lys Leu Gln Ser Glu Cys His Pro Asp Thr 

    50                  55                  60                  





Cys Thr Gln Met Thr Ala Thr Glu Gln Trp Ile Phe Leu Cys Ala Ala 

65                  70                  75                  80  





His Lys Thr Pro Lys Glu Cys Pro Ala Ile Asp Tyr Thr Arg His Thr 

                85                  90                  95      





Leu Asp Gly Ala Ala Cys Leu Leu Asn Ser Asn Lys Tyr Phe Pro Ser 

            100                 105                 110         





Arg Val Ser Ile Lys Glu Ser Ser Val Ala Lys Leu Gly Ser Val Cys 

        115                 120                 125             





Arg Arg Ile Tyr Arg Ile Phe Ser His Ala Tyr Phe His His Arg Gln 

    130                 135                 140                 





Ile Phe Asp Glu Tyr Glu Asn Glu Thr Phe Leu Cys His Arg Phe Thr 

145                 150                 155                 160 





Lys Phe Val Met Lys Tyr Asn Leu Met Ser Lys Asp Asn Leu Ile Val 

                165                 170                 175     





Pro Ile Leu Glu Glu Glu Val Gln Asn Ser Val Ser Gly Glu Ser Glu 

            180                 185                 190         





Ala 

    





<210>  146

<211>  1243

<212>  DNA

<213>  Homo sapiens



<400>  146

ggacgcaacc atctgcggaa aggatagggg ggaggaagac ttaacactgc aacaacaggt       60



acaaaaaaga aggaaactca gtaacaggac ccagaggacc attatatatt gctctatatt      120



ctaggtcgcc cactttacac ttccttctca tgcacttggt caataccacg cccgctgacc      180



acactggcga cttccctctc tgtcgcccct ccgtgaagtc agacccactc tgcgggccaa      240



gaaaggtgac cgggcttcct tccggcttgc taagcagagg ccggaagcgg tggtttttag      300



cggctctctg ggtagcaggg tggtgtgata gcggcagcga ggggctcgga gaggtgctcg      360



gattctcgta gctgtgccgg gacttaacca ccaccatgtc gagcaaaaga acaaagacca      420



agaccaagaa gcgccctcag cgtgcaacat ccaatgtgtt tgctatgttt gaccagtcgc      480



agattcagga gttcaaagag gccttcaaca tgattgatca gaacagagat ggtttcatcg      540



acaaggaaga tttgcatgat atgcttgctt cattggggaa gaatccaact gatgagtatc      600



tagatgccat gatgaatgag gctccaggcc ccatcaattt caccatgttc ctcaccatgt      660



ttggtgagaa gttaaatggc acagatcctg aagatgtcat cagaaatgcc tttgcttgct      720



ttgatgaaga agcaactggc accatacagg aagattactt gagagagctg ctgacaacca      780



tgggggatcg gtttacagat gaggaagtgg atgagctgta cagagaagca cctattgata      840



aaaaggggaa tttcaattac atcgagttca cacgcatcct gaaacatgga gccaaagaca      900



aagatgactg aaataacttc aaattccagc caaacgttcc ttgttgccac tttgggtatt      960



ctgagatttt ctcttgcatg cccttagctt tacagctttt gcatttcctg ttgtatttat     1020



tctcagccat tttgggcata tgtatcttta taatcagact ggaaacggga ctttctatta     1080



atatcatttt cagaataaaa aataggataa tttaacctac cagcccttct cccccaataa     1140



ctgtggtcta tacagagtca atatattttt tcggagaaag ttattcgctc gattttttct     1200



gaatcataat taaactttat gataaaataa aaaaaaaaaa aaa                       1243





<210>  147

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  147



Met Ser Ser Lys Arg Thr Lys Thr Lys Thr Lys Lys Arg Pro Gln Arg 

1               5                   10                  15      





Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 

            20                  25                  30          





Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 

        35                  40                  45              





Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 

    50                  55                  60                  





Thr Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro Ile 

65                  70                  75                  80  





Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 

                85                  90                  95      





Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 

            100                 105                 110         





Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr 

        115                 120                 125             





Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu 

    130                 135                 140                 





Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg 

145                 150                 155                 160 





Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 

                165                 170     





<210>  148

<211>  2544

<212>  DNA

<213>  Homo sapiens



<400>  148

ggactgacct accgaccatt cttccgggtc cagaaggtga tctccgcccg tgctcagaat       60



ccaggggccc ggggctgtag attccttgac aaggatatcc tagcggcgaa acaacaccgt      120



actgggagtc agaacgtctg ggttctagtc ttgactgcca ttaactagcg gtatgacatt      180



ggagaagctt ttttgaccct tctggatttc cgtttccttt tctgtaaaat gaggagcttg      240



gaagatccgg aaaatgaggc ccataggaaa caagtgactt gctgagtcca gataacactg      300



actgtcagag agaaacatga accagaagct actgaagttg gagaacttgc tacgatttca      360



cactatttat aggcaactgc acagtctgtg tcaaagaaga gcattaagac agtggaggca      420



tgggttttca tctgcttacc ctgtgtggac agctcaactg tgtgcctggc cctggccaac      480



agatgtgctc actggggctg ctttatctca gtataggctt ctagtaacaa aaaaggaaga      540



aggaccatgg aaatctcagt tatcttcaac aaaatctaaa aaggtggtag aagtatggat      600



tggaatgact attgaggaac tggccagggc aatggaaaaa aacacagatt atgtatatga      660



agctttattg aacactgata ttgacataga ttcactggaa gcagactcac atttagatga      720



agtctggatc aaagaagtga taacgaaggc agggatgaag ttaaagtgga gtaaattaaa      780



acaggacaaa gtcagaaaaa ataaagatgc tgtaagaagg ccccaggcag atccagcttt      840



attaacccca aggtccccag ttgttactat aatgggccat gttgatcacg ggaaaacgac      900



attacttgac aaatttcgaa aaactcaagt ggcagcagtg gaaactggag gcatcactca      960



gcacattggt gcctttcttg tctctctgcc ttctggggaa aagataactt ttcttgatac     1020



tccaggacat gctgctttct cagcaatgag agccagaggt gctcaggtca ctgacattgt     1080



cgtattggtt gtagctgcag atgatggagt gatgaaacaa actgtagaat ctattcagca     1140



tgccaaagat gcacaggttc ctattatcct tgccgtaaat aaatgtgaca aagctgaggc     1200



tgatcctgag aaagtgaaaa aagagctgct ggcttacgat gtggtatgtg aagattatgg     1260



aggtgatgtt caagcagtgc ctgtctccgc acttacgggc gataatctga tggctttggc     1320



agaagcaaca gttgctcttg cagaaatgtt agaattgaaa gcagatccca atggtccagt     1380



ggaaggaaca gtaatagagt ctttcacaga caaaggaaga ggtcttgtta ctacagctat     1440



aattcaaaga ggaactttaa gaaaaggctc tgttctggtt gctggaaaat gttgggcaaa     1500



agtacgctta atgtttgatg aaaatggaaa aacaattgat gaggcctatc ccagcatgcc     1560



agtgggaatt acaggctgga gagaccttcc ttctgcagga gaagaaattc ttgaagtaga     1620



atctgagcca agggcacgtg aagttgttga ctggaggaaa tatgaacaag aacaggagaa     1680



aggtcaggag gatctgaaaa taatagaaga aaagcgaaag gaacacaaag aagcacatca     1740



gaaagcccgt gagaagtatg gccatctact gtggaagaag agatcaattc tacggttttt     1800



agaaagaaaa gaacaaatac ccttaaagcc aaaagagaaa agggaaagag attcaaatgt     1860



actttctgtg attattaaag gtgatgttga tggttctgtt gaggccattt tgaacattat     1920



agatacctat gatgcttcac acgagtgtga actagaatta gtacattttg gagtgggtga     1980



tgtaagtgca aatgatgtta accttgctga aacatttgat ggtgttatat atggctttaa     2040



tgtgaatgca ggcaatgtta tccaacagtc agctgcaaaa aaaggagtaa aaattaaact     2100



tcacaaaata atttaccgtc ttgttgaaga tttgcaagag gaactgagca gcagattacc     2160



ctgtgctgtg gaagagcacc cagtaggtga ggcatctata ctagctacct tctctgtaac     2220



agaagggaag aaaaaagttc ctgtggctgg ctgcagagtc caaaagggac agttagaaaa     2280



acaaaaaaaa tttaaactaa cccgtaatgg acatgtaatt tggaagggct cattaacctc     2340



attgaaacac cataaagatg acatttcaat tgtcaaaacg ggaatggatt gtggtctcag     2400



tttagatgaa gacaatatgg aatttcaagt gggagacaga attgtttgtt atgaagaaaa     2460



gcaaattcaa gccaagactt cttgggatcc aggattttaa aattacatta aaaatgtaaa     2520



taactcaaaa aaaaaaaaaa aaaa                                            2544





<210>  149

<211>  727

<212>  PRT

<213>  Homo sapiens



<400>  149



Met Asn Gln Lys Leu Leu Lys Leu Glu Asn Leu Leu Arg Phe His Thr 

1               5                   10                  15      





Ile Tyr Arg Gln Leu His Ser Leu Cys Gln Arg Arg Ala Leu Arg Gln 

            20                  25                  30          





Trp Arg His Gly Phe Ser Ser Ala Tyr Pro Val Trp Thr Ala Gln Leu 

        35                  40                  45              





Cys Ala Trp Pro Trp Pro Thr Asp Val Leu Thr Gly Ala Ala Leu Ser 

    50                  55                  60                  





Gln Tyr Arg Leu Leu Val Thr Lys Lys Glu Glu Gly Pro Trp Lys Ser 

65                  70                  75                  80  





Gln Leu Ser Ser Thr Lys Ser Lys Lys Val Val Glu Val Trp Ile Gly 

                85                  90                  95      





Met Thr Ile Glu Glu Leu Ala Arg Ala Met Glu Lys Asn Thr Asp Tyr 

            100                 105                 110         





Val Tyr Glu Ala Leu Leu Asn Thr Asp Ile Asp Ile Asp Ser Leu Glu 

        115                 120                 125             





Ala Asp Ser His Leu Asp Glu Val Trp Ile Lys Glu Val Ile Thr Lys 

    130                 135                 140                 





Ala Gly Met Lys Leu Lys Trp Ser Lys Leu Lys Gln Asp Lys Val Arg 

145                 150                 155                 160 





Lys Asn Lys Asp Ala Val Arg Arg Pro Gln Ala Asp Pro Ala Leu Leu 

                165                 170                 175     





Thr Pro Arg Ser Pro Val Val Thr Ile Met Gly His Val Asp His Gly 

            180                 185                 190         





Lys Thr Thr Leu Leu Asp Lys Phe Arg Lys Thr Gln Val Ala Ala Val 

        195                 200                 205             





Glu Thr Gly Gly Ile Thr Gln His Ile Gly Ala Phe Leu Val Ser Leu 

    210                 215                 220                 





Pro Ser Gly Glu Lys Ile Thr Phe Leu Asp Thr Pro Gly His Ala Ala 

225                 230                 235                 240 





Phe Ser Ala Met Arg Ala Arg Gly Ala Gln Val Thr Asp Ile Val Val 

                245                 250                 255     





Leu Val Val Ala Ala Asp Asp Gly Val Met Lys Gln Thr Val Glu Ser 

            260                 265                 270         





Ile Gln His Ala Lys Asp Ala Gln Val Pro Ile Ile Leu Ala Val Asn 

        275                 280                 285             





Lys Cys Asp Lys Ala Glu Ala Asp Pro Glu Lys Val Lys Lys Glu Leu 

    290                 295                 300                 





Leu Ala Tyr Asp Val Val Cys Glu Asp Tyr Gly Gly Asp Val Gln Ala 

305                 310                 315                 320 





Val Pro Val Ser Ala Leu Thr Gly Asp Asn Leu Met Ala Leu Ala Glu 

                325                 330                 335     





Ala Thr Val Ala Leu Ala Glu Met Leu Glu Leu Lys Ala Asp Pro Asn 

            340                 345                 350         





Gly Pro Val Glu Gly Thr Val Ile Glu Ser Phe Thr Asp Lys Gly Arg 

        355                 360                 365             





Gly Leu Val Thr Thr Ala Ile Ile Gln Arg Gly Thr Leu Arg Lys Gly 

    370                 375                 380                 





Ser Val Leu Val Ala Gly Lys Cys Trp Ala Lys Val Arg Leu Met Phe 

385                 390                 395                 400 





Asp Glu Asn Gly Lys Thr Ile Asp Glu Ala Tyr Pro Ser Met Pro Val 

                405                 410                 415     





Gly Ile Thr Gly Trp Arg Asp Leu Pro Ser Ala Gly Glu Glu Ile Leu 

            420                 425                 430         





Glu Val Glu Ser Glu Pro Arg Ala Arg Glu Val Val Asp Trp Arg Lys 

        435                 440                 445             





Tyr Glu Gln Glu Gln Glu Lys Gly Gln Glu Asp Leu Lys Ile Ile Glu 

    450                 455                 460                 





Glu Lys Arg Lys Glu His Lys Glu Ala His Gln Lys Ala Arg Glu Lys 

465                 470                 475                 480 





Tyr Gly His Leu Leu Trp Lys Lys Arg Ser Ile Leu Arg Phe Leu Glu 

                485                 490                 495     





Arg Lys Glu Gln Ile Pro Leu Lys Pro Lys Glu Lys Arg Glu Arg Asp 

            500                 505                 510         





Ser Asn Val Leu Ser Val Ile Ile Lys Gly Asp Val Asp Gly Ser Val 

        515                 520                 525             





Glu Ala Ile Leu Asn Ile Ile Asp Thr Tyr Asp Ala Ser His Glu Cys 

    530                 535                 540                 





Glu Leu Glu Leu Val His Phe Gly Val Gly Asp Val Ser Ala Asn Asp 

545                 550                 555                 560 





Val Asn Leu Ala Glu Thr Phe Asp Gly Val Ile Tyr Gly Phe Asn Val 

                565                 570                 575     





Asn Ala Gly Asn Val Ile Gln Gln Ser Ala Ala Lys Lys Gly Val Lys 

            580                 585                 590         





Ile Lys Leu His Lys Ile Ile Tyr Arg Leu Val Glu Asp Leu Gln Glu 

        595                 600                 605             





Glu Leu Ser Ser Arg Leu Pro Cys Ala Val Glu Glu His Pro Val Gly 

    610                 615                 620                 





Glu Ala Ser Ile Leu Ala Thr Phe Ser Val Thr Glu Gly Lys Lys Lys 

625                 630                 635                 640 





Val Pro Val Ala Gly Cys Arg Val Gln Lys Gly Gln Leu Glu Lys Gln 

                645                 650                 655     





Lys Lys Phe Lys Leu Thr Arg Asn Gly His Val Ile Trp Lys Gly Ser 

            660                 665                 670         





Leu Thr Ser Leu Lys His His Lys Asp Asp Ile Ser Ile Val Lys Thr 

        675                 680                 685             





Gly Met Asp Cys Gly Leu Ser Leu Asp Glu Asp Asn Met Glu Phe Gln 

    690                 695                 700                 





Val Gly Asp Arg Ile Val Cys Tyr Glu Glu Lys Gln Ile Gln Ala Lys 

705                 710                 715                 720 





Thr Ser Trp Asp Pro Gly Phe 

                725         





<210>  150

<211>  2965

<212>  DNA

<213>  Homo sapiens



<400>  150

cggggctgta ggtaggagtt aagtgggtag gatcccttaa ccagggttgt ccggtgcagg       60



tggtgtgtgt tgtttcgcct aacgtgtcag tggcacaaat cacgcgaact tcataaacat      120



tgtgcgttcg gaagcctttc caagatgcat ttaatccctg cgtgagccca cgttaggcat      180



tcacgaaggc atgtgcactg ttctctcgga agcggctggc cggcttcccc tcctcgcgcg      240



cggctgtggg tgcaggtcct cacttcccag cctcccatgg gcccaaggcc ttctgggctc      300



caatttgagg cgagccaccc cagatccgta atttttctgc agtgatttat ttttaccttt      360



ctgattcctt gacaaggata tcctagcggc gaaacaacac cgtactggga gtcagaacgt      420



ctgggttcta gtcttgactg ccattaacta gcggtatgac attggagaag cttttttgac      480



ccttctggat ttccgtttcc ttttctgtaa aatgaggagc ttggaagatc cggaaaatga      540



ggcccatagg aaacaagtga cttgctgagt ccagataaca ctgactgtca gaagtctcgc      600



tctgtctccc cggctggagt gcagtggcgt gatcttggct cactgcaacc tctgtctccc      660



gggttcaaga aattctcctg cctcagcctc ccaagtagct gggactacag gcatgtgcca      720



ccacgcccag gagaaacatg aaccagaagc tactgaagtt ggagaacttg ctacgatttc      780



acactattta taggcaactg cacagtctgt gtcaaagaag agcattaaga cagtggaggc      840



atgggttttc atctgcttac cctgtgtgga cagctcaact gtgtgcctgg ccctggccaa      900



cagatgtgct cactggggct gctttatctc agtataggct tctagtaaca aaaaaggaag      960



aaggaccatg gaaatctcag ttatcttcaa caaaatctaa aaaggtggta gaagtatgga     1020



ttggaatgac tattgaggaa ctggccaggg caatggaaaa aaacacagat tatgtatatg     1080



aagctttatt gaacactgat attgacatag attcactgga agcagactca catttagatg     1140



aagtctggat caaagaagtg ataacgaagg cagggatgaa gttaaagtgg agtaaattaa     1200



aacaggacaa agtcagaaaa aataaagatg ctgtaagaag gccccaggca gatccagctt     1260



tattaacccc aaggtcccca gttgttacta taatgggcca tgttgatcac gggaaaacga     1320



cattacttga caaatttcga aaaactcaag tggcagcagt ggaaactgga ggcatcactc     1380



agcacattgg tgcctttctt gtctctctgc cttctgggga aaagataact tttcttgata     1440



ctccaggaca tgctgctttc tcagcaatga gagccagagg tgctcaggtc actgacattg     1500



tcgtattggt tgtagctgca gatgatggag tgatgaaaca aactgtagaa tctattcagc     1560



atgccaaaga tgcacaggtt cctattatcc ttgccgtaaa taaatgtgac aaagctgagg     1620



ctgatcctga gaaagtgaaa aaagagctgc tggcttacga tgtggtatgt gaagattatg     1680



gaggtgatgt tcaagcagtg cctgtctccg cacttacggg cgataatctg atggctttgg     1740



cagaagcaac agttgctctt gcagaaatgt tagaattgaa agcagatccc aatggtccag     1800



tggaaggaac agtaatagag tctttcacag acaaaggaag aggtcttgtt actacagcta     1860



taattcaaag aggaacttta agaaaaggct ctgttctggt tgctggaaaa tgttgggcaa     1920



aagtacgctt aatgtttgat gaaaatggaa aaacaattga tgaggcctat cccagcatgc     1980



cagtgggaat tacaggctgg agagaccttc cttctgcagg agaagaaatt cttgaagtag     2040



aatctgagcc aagggcacgt gaagttgttg actggaggaa atatgaacaa gaacaggaga     2100



aaggtcagga ggatctgaaa ataatagaag aaaagcgaaa ggaacacaaa gaagcacatc     2160



agaaagcccg tgagaagtat ggccatctac tgtggaagaa gagatcaatt ctacggtttt     2220



tagaaagaaa agaacaaata cccttaaagc caaaagagaa aagggaaaga gattcaaatg     2280



tactttctgt gattattaaa ggtgatgttg atggttctgt tgaggccatt ttgaacatta     2340



tagataccta tgatgcttca cacgagtgtg aactagaatt agtacatttt ggagtgggtg     2400



atgtaagtgc aaatgatgtt aaccttgctg aaacatttga tggtgttata tatggcttta     2460



atgtgaatgc aggcaatgtt atccaacagt cagctgcaaa aaaaggagta aaaattaaac     2520



ttcacaaaat aatttaccgt cttgttgaag atttgcaaga ggaactgagc agcagattac     2580



cctgtgctgt ggaagagcac ccagtaggtg aggcatctat actagctacc ttctctgtaa     2640



cagaagggaa gaaaaaagtt cctgtggctg gctgcagagt ccaaaaggga cagttagaaa     2700



aacaaaaaaa atttaaacta acccgtaatg gacatgtaat ttggaagggc tcattaacct     2760



cattgaaaca ccataaagat gacatttcaa ttgtcaaaac gggaatggat tgtggtctca     2820



gtttagatga agacaatatg gaatttcaag tgggagacag aattgtttgt tatgaagaaa     2880



agcaaattca agccaagact tcttgggatc caggatttta aaattacatt aaaaatgtaa     2940



ataactcaaa aaaaaaaaaa aaaaa                                           2965





<210>  151

<211>  727

<212>  PRT

<213>  Homo sapiens



<400>  151



Met Asn Gln Lys Leu Leu Lys Leu Glu Asn Leu Leu Arg Phe His Thr 

1               5                   10                  15      





Ile Tyr Arg Gln Leu His Ser Leu Cys Gln Arg Arg Ala Leu Arg Gln 

            20                  25                  30          





Trp Arg His Gly Phe Ser Ser Ala Tyr Pro Val Trp Thr Ala Gln Leu 

        35                  40                  45              





Cys Ala Trp Pro Trp Pro Thr Asp Val Leu Thr Gly Ala Ala Leu Ser 

    50                  55                  60                  





Gln Tyr Arg Leu Leu Val Thr Lys Lys Glu Glu Gly Pro Trp Lys Ser 

65                  70                  75                  80  





Gln Leu Ser Ser Thr Lys Ser Lys Lys Val Val Glu Val Trp Ile Gly 

                85                  90                  95      





Met Thr Ile Glu Glu Leu Ala Arg Ala Met Glu Lys Asn Thr Asp Tyr 

            100                 105                 110         





Val Tyr Glu Ala Leu Leu Asn Thr Asp Ile Asp Ile Asp Ser Leu Glu 

        115                 120                 125             





Ala Asp Ser His Leu Asp Glu Val Trp Ile Lys Glu Val Ile Thr Lys 

    130                 135                 140                 





Ala Gly Met Lys Leu Lys Trp Ser Lys Leu Lys Gln Asp Lys Val Arg 

145                 150                 155                 160 





Lys Asn Lys Asp Ala Val Arg Arg Pro Gln Ala Asp Pro Ala Leu Leu 

                165                 170                 175     





Thr Pro Arg Ser Pro Val Val Thr Ile Met Gly His Val Asp His Gly 

            180                 185                 190         





Lys Thr Thr Leu Leu Asp Lys Phe Arg Lys Thr Gln Val Ala Ala Val 

        195                 200                 205             





Glu Thr Gly Gly Ile Thr Gln His Ile Gly Ala Phe Leu Val Ser Leu 

    210                 215                 220                 





Pro Ser Gly Glu Lys Ile Thr Phe Leu Asp Thr Pro Gly His Ala Ala 

225                 230                 235                 240 





Phe Ser Ala Met Arg Ala Arg Gly Ala Gln Val Thr Asp Ile Val Val 

                245                 250                 255     





Leu Val Val Ala Ala Asp Asp Gly Val Met Lys Gln Thr Val Glu Ser 

            260                 265                 270         





Ile Gln His Ala Lys Asp Ala Gln Val Pro Ile Ile Leu Ala Val Asn 

        275                 280                 285             





Lys Cys Asp Lys Ala Glu Ala Asp Pro Glu Lys Val Lys Lys Glu Leu 

    290                 295                 300                 





Leu Ala Tyr Asp Val Val Cys Glu Asp Tyr Gly Gly Asp Val Gln Ala 

305                 310                 315                 320 





Val Pro Val Ser Ala Leu Thr Gly Asp Asn Leu Met Ala Leu Ala Glu 

                325                 330                 335     





Ala Thr Val Ala Leu Ala Glu Met Leu Glu Leu Lys Ala Asp Pro Asn 

            340                 345                 350         





Gly Pro Val Glu Gly Thr Val Ile Glu Ser Phe Thr Asp Lys Gly Arg 

        355                 360                 365             





Gly Leu Val Thr Thr Ala Ile Ile Gln Arg Gly Thr Leu Arg Lys Gly 

    370                 375                 380                 





Ser Val Leu Val Ala Gly Lys Cys Trp Ala Lys Val Arg Leu Met Phe 

385                 390                 395                 400 





Asp Glu Asn Gly Lys Thr Ile Asp Glu Ala Tyr Pro Ser Met Pro Val 

                405                 410                 415     





Gly Ile Thr Gly Trp Arg Asp Leu Pro Ser Ala Gly Glu Glu Ile Leu 

            420                 425                 430         





Glu Val Glu Ser Glu Pro Arg Ala Arg Glu Val Val Asp Trp Arg Lys 

        435                 440                 445             





Tyr Glu Gln Glu Gln Glu Lys Gly Gln Glu Asp Leu Lys Ile Ile Glu 

    450                 455                 460                 





Glu Lys Arg Lys Glu His Lys Glu Ala His Gln Lys Ala Arg Glu Lys 

465                 470                 475                 480 





Tyr Gly His Leu Leu Trp Lys Lys Arg Ser Ile Leu Arg Phe Leu Glu 

                485                 490                 495     





Arg Lys Glu Gln Ile Pro Leu Lys Pro Lys Glu Lys Arg Glu Arg Asp 

            500                 505                 510         





Ser Asn Val Leu Ser Val Ile Ile Lys Gly Asp Val Asp Gly Ser Val 

        515                 520                 525             





Glu Ala Ile Leu Asn Ile Ile Asp Thr Tyr Asp Ala Ser His Glu Cys 

    530                 535                 540                 





Glu Leu Glu Leu Val His Phe Gly Val Gly Asp Val Ser Ala Asn Asp 

545                 550                 555                 560 





Val Asn Leu Ala Glu Thr Phe Asp Gly Val Ile Tyr Gly Phe Asn Val 

                565                 570                 575     





Asn Ala Gly Asn Val Ile Gln Gln Ser Ala Ala Lys Lys Gly Val Lys 

            580                 585                 590         





Ile Lys Leu His Lys Ile Ile Tyr Arg Leu Val Glu Asp Leu Gln Glu 

        595                 600                 605             





Glu Leu Ser Ser Arg Leu Pro Cys Ala Val Glu Glu His Pro Val Gly 

    610                 615                 620                 





Glu Ala Ser Ile Leu Ala Thr Phe Ser Val Thr Glu Gly Lys Lys Lys 

625                 630                 635                 640 





Val Pro Val Ala Gly Cys Arg Val Gln Lys Gly Gln Leu Glu Lys Gln 

                645                 650                 655     





Lys Lys Phe Lys Leu Thr Arg Asn Gly His Val Ile Trp Lys Gly Ser 

            660                 665                 670         





Leu Thr Ser Leu Lys His His Lys Asp Asp Ile Ser Ile Val Lys Thr 

        675                 680                 685             





Gly Met Asp Cys Gly Leu Ser Leu Asp Glu Asp Asn Met Glu Phe Gln 

    690                 695                 700                 





Val Gly Asp Arg Ile Val Cys Tyr Glu Glu Lys Gln Ile Gln Ala Lys 

705                 710                 715                 720 





Thr Ser Trp Asp Pro Gly Phe 

                725         





<210>  152

<211>  7505

<212>  DNA

<213>  Homo sapiens



<400>  152

gagggcgggg cgggaaggcg gcgaggagcc gagctgggtg cggtgaggcg cgcagatcac       60



cgcggttcct gggcagggca cggaaggcta agcaaggctg acctgctgca gctcccgcct      120



cgtgcgctcg ccccacccgg ccgccgcccg agcgctcgag aaagtcctct cgggagaagc      180



agcgcctgtt cccggggcag atccaggttc aggtcctggc tataagtcac catggcacag      240



caagctgccg ataagtatct ctatgtggat aaaaacttca tcaacaatcc gctggcccag      300



gccgactggg ctgccaagaa gctggtatgg gtgccttccg acaagagtgg ctttgagcca      360



gccagcctca aggaggaggt gggcgaagag gccatcgtgg agctggtgga gaatgggaag      420



aaggtgaagg tgaacaagga tgacatccag aagatgaacc cgcccaagtt ctccaaggtg      480



gaggacatgg cagagctcac gtgcctcaac gaagcctcgg tgctgcacaa cctcaaggag      540



cgttactact cagggctcat ctacacctat tcaggcctgt tctgtgtggt catcaatcct      600



tacaagaacc tgcccatcta ctctgaagag attgtggaaa tgtacaaggg caagaagagg      660



cacgagatgc cccctcacat ctatgccatc acagacaccg cctacaggag tatgatgcaa      720



gaccgagaag atcaatccat cttgtgcact ggtgaatctg gagctggcaa gacggagaac      780



accaagaagg tcatccagta tctggcgtac gtggcgtcct cgcacaagag caagaaggac      840



cagggcgagc tggagcggca gctgctgcag gccaacccca tcctggaggc cttcgggaac      900



gccaagaccg tgaagaatga caactcctcc cgcttcggca aattcattcg catcaacttt      960



gatgtcaatg gctacattgt tggagccaac attgagactt atcttttgga gaaatctcgt     1020



gctatccgcc aagccaagga agaacggacc ttccacatct tctattatct cctgtctggg     1080



gctggagagc acctgaagac cgatctcctg ttggagccgt acaacaaata ccgcttcctg     1140



tccaatggac acgtcaccat ccccgggcag caggacaagg acatgttcca ggagaccatg     1200



gaggccatga ggattatggg catcccagaa gaggagcaaa tgggcctgct gcgggtcatc     1260



tcaggggttc ttcagctcgg caacatcgtc ttcaagaagg agcggaacac tgaccaggcg     1320



tccatgcccg acaacacagc tgcccaaaag gtgtcccatc tcttgggtat caatgtgacc     1380



gatttcacca gaggaatcct caccccgcgc atcaaggtgg gacgggatta cgtccagaag     1440



gcgcagacta aagagcaggc tgactttgcc atcgaggcct tggccaaggc gacctatgag     1500



cggatgttcc gctggctggt gctgcgcatc aacaaggctc tggacaagac caagaggcag     1560



ggcgcctcct tcatcgggat cctggacatt gccggcttcg agatctttga tctgaactcg     1620



tttgagcagc tgtgcatcaa ttacaccaat gagaagctgc agcagctctt caaccacacc     1680



atgttcatcc tggagcagga ggagtaccag cgcgagggca tcgagtggaa cttcatcgac     1740



tttggcctcg acctgcagcc ctgcatcgac ctcattgaga agccagcagg ccccccgggc     1800



attctggccc tgctggacga ggagtgctgg ttccccaaag ccaccgacaa gagcttcgtg     1860



gagaaggtga tgcaggagca gggcacccac cccaagttcc agaagcccaa gcagctgaag     1920



gacaaagctg atttctgcat tatccactat gccggcaagg tggattacaa agctgacgag     1980



tggctgatga agaacatgga tcccctgaat gacaacatcg ccacactgct ccaccagtcc     2040



tctgacaagt ttgtctcgga gctgtggaag gatgtggacc gcatcatcgg cctggaccag     2100



gtggccggca tgtcggagac cgcactgccc ggggccttca agacgcggaa gggcatgttc     2160



cgcactgtgg ggcagcttta caaggagcag ctggccaagc tgatggctac gctgaggaac     2220



acgaacccca actttgtccg ctgcatcatc cccaaccacg agaagaaggc cggcaagctg     2280



gacccgcatc tcgtgctgga ccagctgcgc tgcaacggtg ttctcgaggg catccgtatc     2340



tgccgccagg gcttccccaa cagggtggtc ttccaggagt ttcggcagag atatgagatc     2400



ctgactccaa actccattcc caagggtttc atggacggga agcaggcgtg cgtgctcatg     2460



ataaaagccc tggagctcga cagcaatctg taccgcattg gccagagcaa agtcttcttc     2520



cgtgccggtg tgctggccca cctggaggag gagcgagacc tgaagatcac cgacgtcatc     2580



atagggttcc aggcctgctg caggggctac ctggccagga aagcatttgc caagcggcag     2640



cagcagctta ccgccatgaa ggtcctccag cggaactgcg ctgcctacct gaagctgcgg     2700



aactggcagt ggtggcggct cttcaccaag gtcaagccgc tgctgcaggt gagccggcag     2760



gaggaggaga tgatggccaa ggaggaggag ctggtgaagg tcagagagaa gcagctggct     2820



gcggagaaca ggctcacgga gatggagacg ctgcagtctc agctcatggc agagaaattg     2880



cagctgcagg agcagctcca ggcagaaacc gagctgtgtg ccgaggctga ggagctccgg     2940



gcccgcctga ccgccaagaa gcaggaatta gaagagatct gccatgacct agaggccagg     3000



gtggaggagg aggaggagcg ctgccagcac ctgcaggcgg agaagaagaa gatgcagcag     3060



aacatccagg agcttgagga gcagctggag gaggaggaga gcgcccggca gaagctgcag     3120



ctggagaagg tgaccaccga ggcgaagctg aaaaagctgg aggaggagca gatcatcctg     3180



gaggaccaga actgcaagct ggccaaggaa aagaaactgc tggaagacag aatagctgag     3240



ttcaccacca acctcacaga agaggaggag aaatctaaga gcctcgccaa gctcaagaac     3300



aagcatgagg caatgatcac tgacttggaa gagcgcctcc gcagggagga gaagcagcga     3360



caggagctgg agaagacccg ccggaagctg gagggagact ccacagacct cagcgaccag     3420



atcgccgagc tccaggccca gatcgcggag ctcaagatgc agctggccaa gaaagaggag     3480



gagctccagg ccgccctggc cagagtggaa gaggaagctg cccagaagaa catggccctc     3540



aagaagatcc gggagctgga atctcagatc tctgaactcc aggaagacct ggagtctgag     3600



cgtgcttcca ggaataaagc tgagaagcag aaacgggacc ttggggaaga gctagaggct     3660



ctgaaaacag agttggagga cacgctggat tccacagctg cccagcagga gctcaggtca     3720



aaacgtgagc aggaggtgaa catcctgaag aagaccctgg aggaggaggc caagacccac     3780



gaggcccaga tccaggagat gaggcagaag cactcacagg ccgtggagga gctggcggag     3840



cagctggagc agacgaagcg ggtgaaagca aacctcgaga aggcaaagca gactctggag     3900



aacgagcggg gggagctggc caacgaggtg aaggtgctgc tgcagggcaa aggggactcg     3960



gagcacaagc gcaagaaagt ggaggcgcag ctgcaggagc tgcaggtcaa gttcaacgag     4020



ggagagcgcg tgcgcacaga gctggccgac aaggtcacca agctgcaggt ggagctggac     4080



aacgtgaccg ggcttctcag ccagtccgac agcaagtcca gcaagctcac caaggacttc     4140



tccgcgctgg agtcccagct gcaggacact caggagctgc tgcaggagga gaaccggcag     4200



aagctgagcc tgagcaccaa gctcaagcag gtggaggacg agaagaattc cttccgggag     4260



cagctggagg aggaggagga ggccaagcac aacctggaga agcagatcgc caccctccat     4320



gcccaggtgg ccgacatgaa aaagaagatg gaggacagtg tggggtgcct ggaaactgct     4380



gaggaggtga agaggaagct ccagaaggac ctggagggcc tgagccagcg gcacgaggag     4440



aaggtggccg cctacgacaa gctggagaag accaagacgc ggctgcagca ggagctggac     4500



gacctgctgg tggacctgga ccaccagcgc cagagcgcgt gcaacctgga gaagaagcag     4560



aagaagtttg accagctcct ggcggaggag aagaccatct ctgccaagta tgcagaggag     4620



cgcgaccggg ctgaggcgga ggcccgagag aaggagacca aggctctgtc gctggcccgg     4680



gccctggagg aagccatgga gcagaaggcg gagctggagc ggctcaacaa gcagttccgc     4740



acggagatgg aggaccttat gagctccaag gatgatgtgg gcaagagtgt ccacgagctg     4800



gagaagtcca agcgggccct agagcagcag gtggaggaga tgaagacgca gctggaagag     4860



ctggaggacg agctgcaggc caccgaagat gccaagctgc ggttggaggt caacctgcag     4920



gccatgaagg cccagttcga gcgggacctg cagggccggg acgagcagag cgaggagaag     4980



aagaagcagc tggtcagaca ggtgcgggag atggaggcag agctggagga cgagaggaag     5040



cagcgctcga tggcagtggc cgcccggaag aagctggaga tggacctgaa ggacctggag     5100



gcgcacatcg actcggccaa caagaaccgg gacgaagcca tcaaacagct gcggaagctg     5160



caggcccaga tgaaggactg catgcgcgag ctggatgaca cccgcgcctc tcgtgaggag     5220



atcctggccc aggccaaaga gaacgagaag aagctgaaga gcatggaggc cgagatgatc     5280



cagttgcagg aggaactggc agccgcggag cgtgccaagc gccaggccca gcaggagcgg     5340



gatgagctgg ctgacgagat cgccaacagc agcggcaaag gagccctggc gttagaggag     5400



aagcggcgtc tggaggcccg catcgcccag ctggaggagg agctggagga ggagcagggc     5460



aacacggagc tgatcaacga ccggctgaag aaggccaacc tgcagatcga ccagatcaac     5520



accgacctga acctggagcg cagccacgcc cagaagaacg agaatgctcg gcagcagctg     5580



gaacgccaga acaaggagct taaggtcaag ctgcaggaga tggagggcac tgtcaagtcc     5640



aagtacaagg cctccatcac cgccctcgag gccaagattg cacagctgga ggagcagctg     5700



gacaacgaga ccaaggagcg ccaggcagcc tgcaaacagg tgcgtcggac cgagaagaag     5760



ctgaaggatg tgctgctgca ggtggatgac gagcggagga acgccgagca gtacaaggac     5820



caggccgaca aggcatctac ccgcctgaag cagctcaagc ggcagctgga ggaggccgaa     5880



gaggaggccc agcgggccaa cgcctcccgc cggaaactgc agcgcgagct ggaggacgcc     5940



actgagacgg ccgatgccat gaaccgcgaa gtcagctccc taaagaacaa gctcaggcgc     6000



ggggacctgc cgtttgtcgt gccccgccga atggcccgga aaggcgccgg ggatggctcc     6060



gacgaagagg tagatggcaa agcggatggg gctgaggcca aacctgccga ataagcctct     6120



tctcctgcag cctgagatgg atggacagac agacaccaca gcctcccctt cccagacccc     6180



gcagcacgcc tctccccacc ttcttgggac tgctgtgaac atgcctcctc ctgccctccg     6240



ccccgtcccc ccatcccgtt tccctccagg tgttgttgag ggcatttggc ttcctctgct     6300



gcatcccctt ccagctccct cccctgctca gaatctgata ccaaagagac agggcccggg     6360



cccaggcaga gagcgaccag caggctcctc agccctctct tgccaaaaag cacaagatgt     6420



tgaggcgagc agggcaggcc cccggggagg ggccagagtt ttctatgaat ctatttttct     6480



tcagactgag gccttttggt agtcggagcc cccgcagtcg tcagcctccc tgacgtctgc     6540



caccagcgcc cccactcctc ctcctttctt tgctgtttgc aatcacacgt ggtgacctca     6600



cacacctctg ccccttgggc ctcccactcc catggctctg ggcggtccag aaggagcagg     6660



ccctgggcct ccacctctgt gcagggcaca gaaggctggg gtggggggag gagtggattc     6720



ctccccaccc tgtcccaggc agcgccactg tccgctgtct ccctcctgat tctaaaatgt     6780



ctcaagtgca atgccccctc ccctccttta ccgaggacag cctgcctctg ccacagcaag     6840



gctgtcgggg tcaagctgga aaggccagca gccttccagt ggcttctccc aacactcttg     6900



gggaccaaat atatttaatg gttaagggac ttgtcccaag tctgacagcc agagcgttag     6960



aggggccagc ggccctccca ggcgatcttg tgtctactct aggactgggc ccgagggtgg     7020



tttacctgca ccgttgactc agtatagttt aaaaatctgc cacctgcaca ggtatttttg     7080



aaagcaaaat aaggttttct tttttcccct ttcttgtaat aaatgataaa attccgagtc     7140



tttctcactg cctttgttta gaagagagta gctcgtcctc actggtctac actggttgcc     7200



gaatttactt gtattcctaa ctgttttgta tatgctgcat tgagacttac ggcaagaagg     7260



catttttttt ttttaaagga aacaaactct caaatcatga agtgatataa aagctgcata     7320



tgcctacaaa gctctgaatt caggtcccag ttgctgtcac aaaggagtga gtgaaactcc     7380



caccctaccc ccttttttat ataataaaag tgccttagca tgtgttgcag ctgtcaccac     7440



tacagtaagc tggtttacag atgttttcca ctgagcatca caataaagag aaccatgtgc     7500



tacga                                                                 7505





<210>  153

<211>  1960

<212>  PRT

<213>  Homo sapiens



<400>  153



Met Ala Gln Gln Ala Ala Asp Lys Tyr Leu Tyr Val Asp Lys Asn Phe 

1               5                   10                  15      





Ile Asn Asn Pro Leu Ala Gln Ala Asp Trp Ala Ala Lys Lys Leu Val 

            20                  25                  30          





Trp Val Pro Ser Asp Lys Ser Gly Phe Glu Pro Ala Ser Leu Lys Glu 

        35                  40                  45              





Glu Val Gly Glu Glu Ala Ile Val Glu Leu Val Glu Asn Gly Lys Lys 

    50                  55                  60                  





Val Lys Val Asn Lys Asp Asp Ile Gln Lys Met Asn Pro Pro Lys Phe 

65                  70                  75                  80  





Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu Asn Glu Ala Ser 

                85                  90                  95      





Val Leu His Asn Leu Lys Glu Arg Tyr Tyr Ser Gly Leu Ile Tyr Thr 

            100                 105                 110         





Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr Lys Asn Leu Pro 

        115                 120                 125             





Ile Tyr Ser Glu Glu Ile Val Glu Met Tyr Lys Gly Lys Lys Arg His 

    130                 135                 140                 





Glu Met Pro Pro His Ile Tyr Ala Ile Thr Asp Thr Ala Tyr Arg Ser 

145                 150                 155                 160 





Met Met Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys Thr Gly Glu Ser 

                165                 170                 175     





Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile Gln Tyr Leu Ala 

            180                 185                 190         





Tyr Val Ala Ser Ser His Lys Ser Lys Lys Asp Gln Gly Glu Leu Glu 

        195                 200                 205             





Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala 

    210                 215                 220                 





Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg 

225                 230                 235                 240 





Ile Asn Phe Asp Val Asn Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr 

                245                 250                 255     





Tyr Leu Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Lys Glu Glu Arg 

            260                 265                 270         





Thr Phe His Ile Phe Tyr Tyr Leu Leu Ser Gly Ala Gly Glu His Leu 

        275                 280                 285             





Lys Thr Asp Leu Leu Leu Glu Pro Tyr Asn Lys Tyr Arg Phe Leu Ser 

    290                 295                 300                 





Asn Gly His Val Thr Ile Pro Gly Gln Gln Asp Lys Asp Met Phe Gln 

305                 310                 315                 320 





Glu Thr Met Glu Ala Met Arg Ile Met Gly Ile Pro Glu Glu Glu Gln 

                325                 330                 335     





Met Gly Leu Leu Arg Val Ile Ser Gly Val Leu Gln Leu Gly Asn Ile 

            340                 345                 350         





Val Phe Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn 

        355                 360                 365             





Thr Ala Ala Gln Lys Val Ser His Leu Leu Gly Ile Asn Val Thr Asp 

    370                 375                 380                 





Phe Thr Arg Gly Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Tyr 

385                 390                 395                 400 





Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Ile Glu Ala 

                405                 410                 415     





Leu Ala Lys Ala Thr Tyr Glu Arg Met Phe Arg Trp Leu Val Leu Arg 

            420                 425                 430         





Ile Asn Lys Ala Leu Asp Lys Thr Lys Arg Gln Gly Ala Ser Phe Ile 

        435                 440                 445             





Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Asp Leu Asn Ser Phe 

    450                 455                 460                 





Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe 

465                 470                 475                 480 





Asn His Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly 

                485                 490                 495     





Ile Glu Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile 

            500                 505                 510         





Asp Leu Ile Glu Lys Pro Ala Gly Pro Pro Gly Ile Leu Ala Leu Leu 

        515                 520                 525             





Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu 

    530                 535                 540                 





Lys Val Met Gln Glu Gln Gly Thr His Pro Lys Phe Gln Lys Pro Lys 

545                 550                 555                 560 





Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile Ile His Tyr Ala Gly Lys 

                565                 570                 575     





Val Asp Tyr Lys Ala Asp Glu Trp Leu Met Lys Asn Met Asp Pro Leu 

            580                 585                 590         





Asn Asp Asn Ile Ala Thr Leu Leu His Gln Ser Ser Asp Lys Phe Val 

        595                 600                 605             





Ser Glu Leu Trp Lys Asp Val Asp Arg Ile Ile Gly Leu Asp Gln Val 

    610                 615                 620                 





Ala Gly Met Ser Glu Thr Ala Leu Pro Gly Ala Phe Lys Thr Arg Lys 

625                 630                 635                 640 





Gly Met Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Ala Lys 

                645                 650                 655     





Leu Met Ala Thr Leu Arg Asn Thr Asn Pro Asn Phe Val Arg Cys Ile 

            660                 665                 670         





Ile Pro Asn His Glu Lys Lys Ala Gly Lys Leu Asp Pro His Leu Val 

        675                 680                 685             





Leu Asp Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys 

    690                 695                 700                 





Arg Gln Gly Phe Pro Asn Arg Val Val Phe Gln Glu Phe Arg Gln Arg 

705                 710                 715                 720 





Tyr Glu Ile Leu Thr Pro Asn Ser Ile Pro Lys Gly Phe Met Asp Gly 

                725                 730                 735     





Lys Gln Ala Cys Val Leu Met Ile Lys Ala Leu Glu Leu Asp Ser Asn 

            740                 745                 750         





Leu Tyr Arg Ile Gly Gln Ser Lys Val Phe Phe Arg Ala Gly Val Leu 

        755                 760                 765             





Ala His Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Ile 

    770                 775                 780                 





Gly Phe Gln Ala Cys Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala 

785                 790                 795                 800 





Lys Arg Gln Gln Gln Leu Thr Ala Met Lys Val Leu Gln Arg Asn Cys 

                805                 810                 815     





Ala Ala Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr 

            820                 825                 830         





Lys Val Lys Pro Leu Leu Gln Val Ser Arg Gln Glu Glu Glu Met Met 

        835                 840                 845             





Ala Lys Glu Glu Glu Leu Val Lys Val Arg Glu Lys Gln Leu Ala Ala 

    850                 855                 860                 





Glu Asn Arg Leu Thr Glu Met Glu Thr Leu Gln Ser Gln Leu Met Ala 

865                 870                 875                 880 





Glu Lys Leu Gln Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Cys 

                885                 890                 895     





Ala Glu Ala Glu Glu Leu Arg Ala Arg Leu Thr Ala Lys Lys Gln Glu 

            900                 905                 910         





Leu Glu Glu Ile Cys His Asp Leu Glu Ala Arg Val Glu Glu Glu Glu 

        915                 920                 925             





Glu Arg Cys Gln His Leu Gln Ala Glu Lys Lys Lys Met Gln Gln Asn 

    930                 935                 940                 





Ile Gln Glu Leu Glu Glu Gln Leu Glu Glu Glu Glu Ser Ala Arg Gln 

945                 950                 955                 960 





Lys Leu Gln Leu Glu Lys Val Thr Thr Glu Ala Lys Leu Lys Lys Leu 

                965                 970                 975     





Glu Glu Glu Gln Ile Ile Leu Glu Asp Gln Asn Cys Lys Leu Ala Lys 

            980                 985                 990         





Glu Lys Lys Leu Leu Glu Asp Arg  Ile Ala Glu Phe Thr  Thr Asn Leu 

        995                 1000                 1005             





Thr Glu  Glu Glu Glu Lys Ser  Lys Ser Leu Ala Lys  Leu Lys Asn 

    1010                 1015                 1020             





Lys His  Glu Ala Met Ile Thr  Asp Leu Glu Glu Arg  Leu Arg Arg 

    1025                 1030                 1035             





Glu Glu  Lys Gln Arg Gln Glu  Leu Glu Lys Thr Arg  Arg Lys Leu 

    1040                 1045                 1050             





Glu Gly  Asp Ser Thr Asp Leu  Ser Asp Gln Ile Ala  Glu Leu Gln 

    1055                 1060                 1065             





Ala Gln  Ile Ala Glu Leu Lys  Met Gln Leu Ala Lys  Lys Glu Glu 

    1070                 1075                 1080             





Glu Leu  Gln Ala Ala Leu Ala  Arg Val Glu Glu Glu  Ala Ala Gln 

    1085                 1090                 1095             





Lys Asn  Met Ala Leu Lys Lys  Ile Arg Glu Leu Glu  Ser Gln Ile 

    1100                 1105                 1110             





Ser Glu  Leu Gln Glu Asp Leu  Glu Ser Glu Arg Ala  Ser Arg Asn 

    1115                 1120                 1125             





Lys Ala  Glu Lys Gln Lys Arg  Asp Leu Gly Glu Glu  Leu Glu Ala 

    1130                 1135                 1140             





Leu Lys  Thr Glu Leu Glu Asp  Thr Leu Asp Ser Thr  Ala Ala Gln 

    1145                 1150                 1155             





Gln Glu  Leu Arg Ser Lys Arg  Glu Gln Glu Val Asn  Ile Leu Lys 

    1160                 1165                 1170             





Lys Thr  Leu Glu Glu Glu Ala  Lys Thr His Glu Ala  Gln Ile Gln 

    1175                 1180                 1185             





Glu Met  Arg Gln Lys His Ser  Gln Ala Val Glu Glu  Leu Ala Glu 

    1190                 1195                 1200             





Gln Leu  Glu Gln Thr Lys Arg  Val Lys Ala Asn Leu  Glu Lys Ala 

    1205                 1210                 1215             





Lys Gln  Thr Leu Glu Asn Glu  Arg Gly Glu Leu Ala  Asn Glu Val 

    1220                 1225                 1230             





Lys Val  Leu Leu Gln Gly Lys  Gly Asp Ser Glu His  Lys Arg Lys 

    1235                 1240                 1245             





Lys Val  Glu Ala Gln Leu Gln  Glu Leu Gln Val Lys  Phe Asn Glu 

    1250                 1255                 1260             





Gly Glu  Arg Val Arg Thr Glu  Leu Ala Asp Lys Val  Thr Lys Leu 

    1265                 1270                 1275             





Gln Val  Glu Leu Asp Asn Val  Thr Gly Leu Leu Ser  Gln Ser Asp 

    1280                 1285                 1290             





Ser Lys  Ser Ser Lys Leu Thr  Lys Asp Phe Ser Ala  Leu Glu Ser 

    1295                 1300                 1305             





Gln Leu  Gln Asp Thr Gln Glu  Leu Leu Gln Glu Glu  Asn Arg Gln 

    1310                 1315                 1320             





Lys Leu  Ser Leu Ser Thr Lys  Leu Lys Gln Val Glu  Asp Glu Lys 

    1325                 1330                 1335             





Asn Ser  Phe Arg Glu Gln Leu  Glu Glu Glu Glu Glu  Ala Lys His 

    1340                 1345                 1350             





Asn Leu  Glu Lys Gln Ile Ala  Thr Leu His Ala Gln  Val Ala Asp 

    1355                 1360                 1365             





Met Lys  Lys Lys Met Glu Asp  Ser Val Gly Cys Leu  Glu Thr Ala 

    1370                 1375                 1380             





Glu Glu  Val Lys Arg Lys Leu  Gln Lys Asp Leu Glu  Gly Leu Ser 

    1385                 1390                 1395             





Gln Arg  His Glu Glu Lys Val  Ala Ala Tyr Asp Lys  Leu Glu Lys 

    1400                 1405                 1410             





Thr Lys  Thr Arg Leu Gln Gln  Glu Leu Asp Asp Leu  Leu Val Asp 

    1415                 1420                 1425             





Leu Asp  His Gln Arg Gln Ser  Ala Cys Asn Leu Glu  Lys Lys Gln 

    1430                 1435                 1440             





Lys Lys  Phe Asp Gln Leu Leu  Ala Glu Glu Lys Thr  Ile Ser Ala 

    1445                 1450                 1455             





Lys Tyr  Ala Glu Glu Arg Asp  Arg Ala Glu Ala Glu  Ala Arg Glu 

    1460                 1465                 1470             





Lys Glu  Thr Lys Ala Leu Ser  Leu Ala Arg Ala Leu  Glu Glu Ala 

    1475                 1480                 1485             





Met Glu  Gln Lys Ala Glu Leu  Glu Arg Leu Asn Lys  Gln Phe Arg 

    1490                 1495                 1500             





Thr Glu  Met Glu Asp Leu Met  Ser Ser Lys Asp Asp  Val Gly Lys 

    1505                 1510                 1515             





Ser Val  His Glu Leu Glu Lys  Ser Lys Arg Ala Leu  Glu Gln Gln 

    1520                 1525                 1530             





Val Glu  Glu Met Lys Thr Gln  Leu Glu Glu Leu Glu  Asp Glu Leu 

    1535                 1540                 1545             





Gln Ala  Thr Glu Asp Ala Lys  Leu Arg Leu Glu Val  Asn Leu Gln 

    1550                 1555                 1560             





Ala Met  Lys Ala Gln Phe Glu  Arg Asp Leu Gln Gly  Arg Asp Glu 

    1565                 1570                 1575             





Gln Ser  Glu Glu Lys Lys Lys  Gln Leu Val Arg Gln  Val Arg Glu 

    1580                 1585                 1590             





Met Glu  Ala Glu Leu Glu Asp  Glu Arg Lys Gln Arg  Ser Met Ala 

    1595                 1600                 1605             





Val Ala  Ala Arg Lys Lys Leu  Glu Met Asp Leu Lys  Asp Leu Glu 

    1610                 1615                 1620             





Ala His  Ile Asp Ser Ala Asn  Lys Asn Arg Asp Glu  Ala Ile Lys 

    1625                 1630                 1635             





Gln Leu  Arg Lys Leu Gln Ala  Gln Met Lys Asp Cys  Met Arg Glu 

    1640                 1645                 1650             





Leu Asp  Asp Thr Arg Ala Ser  Arg Glu Glu Ile Leu  Ala Gln Ala 

    1655                 1660                 1665             





Lys Glu  Asn Glu Lys Lys Leu  Lys Ser Met Glu Ala  Glu Met Ile 

    1670                 1675                 1680             





Gln Leu  Gln Glu Glu Leu Ala  Ala Ala Glu Arg Ala  Lys Arg Gln 

    1685                 1690                 1695             





Ala Gln  Gln Glu Arg Asp Glu  Leu Ala Asp Glu Ile  Ala Asn Ser 

    1700                 1705                 1710             





Ser Gly  Lys Gly Ala Leu Ala  Leu Glu Glu Lys Arg  Arg Leu Glu 

    1715                 1720                 1725             





Ala Arg  Ile Ala Gln Leu Glu  Glu Glu Leu Glu Glu  Glu Gln Gly 

    1730                 1735                 1740             





Asn Thr  Glu Leu Ile Asn Asp  Arg Leu Lys Lys Ala  Asn Leu Gln 

    1745                 1750                 1755             





Ile Asp  Gln Ile Asn Thr Asp  Leu Asn Leu Glu Arg  Ser His Ala 

    1760                 1765                 1770             





Gln Lys  Asn Glu Asn Ala Arg  Gln Gln Leu Glu Arg  Gln Asn Lys 

    1775                 1780                 1785             





Glu Leu  Lys Val Lys Leu Gln  Glu Met Glu Gly Thr  Val Lys Ser 

    1790                 1795                 1800             





Lys Tyr  Lys Ala Ser Ile Thr  Ala Leu Glu Ala Lys  Ile Ala Gln 

    1805                 1810                 1815             





Leu Glu  Glu Gln Leu Asp Asn  Glu Thr Lys Glu Arg  Gln Ala Ala 

    1820                 1825                 1830             





Cys Lys  Gln Val Arg Arg Thr  Glu Lys Lys Leu Lys  Asp Val Leu 

    1835                 1840                 1845             





Leu Gln  Val Asp Asp Glu Arg  Arg Asn Ala Glu Gln  Tyr Lys Asp 

    1850                 1855                 1860             





Gln Ala  Asp Lys Ala Ser Thr  Arg Leu Lys Gln Leu  Lys Arg Gln 

    1865                 1870                 1875             





Leu Glu  Glu Ala Glu Glu Glu  Ala Gln Arg Ala Asn  Ala Ser Arg 

    1880                 1885                 1890             





Arg Lys  Leu Gln Arg Glu Leu  Glu Asp Ala Thr Glu  Thr Ala Asp 

    1895                 1900                 1905             





Ala Met  Asn Arg Glu Val Ser  Ser Leu Lys Asn Lys  Leu Arg Arg 

    1910                 1915                 1920             





Gly Asp  Leu Pro Phe Val Val  Pro Arg Arg Met Ala  Arg Lys Gly 

    1925                 1930                 1935             





Ala Gly  Asp Gly Ser Asp Glu  Glu Val Asp Gly Lys  Ala Asp Gly 

    1940                 1945                 1950             





Ala Glu  Ala Lys Pro Ala Glu  

    1955                 1960 





<210>  154

<211>  1128

<212>  DNA

<213>  Homo sapiens



<400>  154

ggttccgcgt tccctgcaca gtaagtactt tctgtgccgc tactgtctat ccgcagccat       60



ccgcctttct ttcgggctaa gccgccccgg ggactgagag ttaaggagag ttggaggctt      120



tactgggcca cagggttcct actcgcccct gggcctccgg acaaaatggg gtctgcggtt      180



ggtgtcctgg caaaagcagg gtagaagggc tgcggggcgg gcccagaatc cgagcctgca      240



gagatgggag cagttgcagt gttgagggcg gaagaggagt gcgtcttgtt ttgggaactg      300



cttcacagga tccagaaaag ggcctccttt ttattccctt ccttcagaaa tgcccggcga      360



agccacagaa accgtccctg ctacagagca ggagttgccg cagccccagg ctgagacagg      420



gtctggaaca gaatctgaca gtgatgaatc agtaccagag cttgaagaac aggattccac      480



ccaggcaacc acacaacaag cccagctggc ggcagcagct gaaattgatg aagaaccagt      540



cagtaaagca aaacagagtc ggagtgaaaa gaaggcacgg aaggctatgt ccaaactggg      600



tcttcggcag gttacaggag ttactagagt cactatccgg aaatctaaga atatcctctt      660



tgtcatcaca aaaccagatg tctacaagag ccctgcttca gatacttaca tagtttttgg      720



ggaagccaag atcgaagatt tatcccagca agcacaacta gcagctgctg agaaattcaa      780



agttcaaggt gaagctgtct caaacattca agaaaacaca cagactccaa ctgtacaaga      840



ggagagtgaa gaggaagagg tcgatgaaac aggtgtagaa gttaaggaca ttgaattggt      900



catgtcacaa gcaaatgtgt cgagagcaaa ggcagtccga gccctgaaga acaacagtaa      960



tgatattgta aatgcgatta tggaattaac aatgtaacca tatggaagca actttttttg     1020



gtgtctcaaa ggagtaactg cagcttggtt tgaaatttgt actgtttcta tcataaataa     1080



agttatggct tcttgttgga tgaattcaaa aaaaaaaaaa aaaaaaaa                  1128





<210>  155

<211>  215

<212>  PRT

<213>  Homo sapiens



<400>  155



Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 

1               5                   10                  15      





Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp 

            20                  25                  30          





Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr 

        35                  40                  45              





Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 

    50                  55                  60                  





Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 

65                  70                  75                  80  





Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile 

                85                  90                  95      





Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr 

            100                 105                 110         





Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile 

        115                 120                 125             





Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 

    130                 135                 140                 





Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro 

145                 150                 155                 160 





Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 

                165                 170                 175     





Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg 

            180                 185                 190         





Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 

        195                 200                 205             





Ala Ile Met Glu Leu Thr Met 

    210                 215 





<210>  156

<211>  1061

<212>  DNA

<213>  Homo sapiens



<400>  156

ggagtctgct tagttctgag gactgcgtgg gtccgcgcag agagctcctg ctaggcctgc       60



gcgtcccgtt ctaaattctt accctttagt ccttgtcacc acccccgccg tgggaacggc      120



ctgacagtca ctcgtcaaag gaagtggctg ccggcagctc ttgacccgga atcggatcct      180



agtcccaccc cctccgctcc aggcttcctt ctgcaacagg cgtgggtcac gctctcgctc      240



ggtctttctg ccgccatctt ggttccgcgt tccctgcaca aaatgcccgg cgaagccaca      300



gaaaccgtcc ctgctacaga gcaggagttg ccgcagcccc aggctgagac agggtctgga      360



acagaatctg acagtgatga atcagtacca gagcttgaag aacaggattc cacccaggca      420



accacacaac aagcccagct ggcggcagca gctgaaattg atgaagaacc agtcagtaaa      480



gcaaaacaga gtcggagtga aaagaaggca cggaaggcta tgtccaaact gggtcttcgg      540



caggttacag gagttactag agtcactatc cggaaatcta agaatatcct ctttgtcatc      600



acaaaaccag atgtctacaa gagccctgct tcagatactt acatagtttt tggggaagcc      660



aagatcgaag atttatccca gcaagcacaa ctagcagctg ctgagaaatt caaagttcaa      720



ggtgaagctg tctcaaacat tcaagaaaac acacagactc caactgtaca agaggagagt      780



gaagaggaag aggtcgatga aacaggtgta gaagttaagg acattgaatt ggtcatgtca      840



caagcaaatg tgtcgagagc aaaggcagtc cgagccctga agaacaacag taatgatatt      900



gtaaatgcga ttatggaatt aacaatgtaa ccatatggaa gcaacttttt ttggtgtctc      960



aaaggagtaa ctgcagcttg gtttgaaatt tgtactgttt ctatcataaa taaagttatg     1020



gcttcttgtt ggatgaattc aaaaaaaaaa aaaaaaaaaa a                         1061





<210>  157

<211>  215

<212>  PRT

<213>  Homo sapiens



<400>  157



Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 

1               5                   10                  15      





Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp 

            20                  25                  30          





Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr 

        35                  40                  45              





Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 

    50                  55                  60                  





Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 

65                  70                  75                  80  





Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile 

                85                  90                  95      





Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr 

            100                 105                 110         





Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile 

        115                 120                 125             





Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 

    130                 135                 140                 





Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro 

145                 150                 155                 160 





Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 

                165                 170                 175     





Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg 

            180                 185                 190         





Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 

        195                 200                 205             





Ala Ile Met Glu Leu Thr Met 

    210                 215 





<210>  158

<211>  6650

<212>  DNA

<213>  Homo sapiens



<400>  158

ggagtctgct tagttctgag gactgcgtgg gtccgcgcag agagctcctg ctaggcctgc       60



gcgtcccgtt ctaaattctt accctttagt ccttgtcacc acccccgccg tgggaacggc      120



ctgacagtca ctcgtcaaag gaagtggctg ccggcagctc ttgacccgga atcggatcct      180



agtcccaccc cctccgctcc aggcttcctt ctgcaacagg cgtgggtcac gctctcgctc      240



ggtctttctg ccgccatctt ggttccgcgt tccctgcaca aaatgcccgg cgaagccaca      300



gaaaccgtcc ctgctacaga gcaggagttg ccgcagcccc aggctgagac agctgtgcta      360



cctatgtctt cagccttgag tgtcactgct gccttagggc agcctggacc taccctcccc      420



cctccttgct ctcctgcccc acaacagtgc cctctctcag ctgctaacca ggcttcccca      480



ttcccttccc cctctactat tgcctcgacc cctttagaag ttccttttcc ccagtcatcc      540



tctggaacag ccctaccttt gggaactgcc cctgaagccc caaccttcct accaaaccta      600



atagggcctc ccatctcccc agctgcctta gctctagcct ctcccatgat agctccaact      660



ctgaaaggga ccccttcctc ttcagctccc ttagctctgg ttgccctggc tccccactca      720



gttcagaaga gttctgcttt tccacctaac cttcttactt cacctccttc agtggctgta      780



gctgagtcag ggtcagtgat aactctgtca gctcccattg ctccctcaga accaaagact      840



aatcttaata aagttccctc tgaggtagtc cctaatccaa aaggcacccc cagccctcca      900



tgtatagtca gtactgttcc ttaccactgt gtgactccca tggcctctat tcaatctgga      960



gtggcctccc ttcctcagac aacacccaca actaccctag ccatcgcttc ccctcaagtc     1020



aaagatacca ccatttcctc agttctgatt tctccacaaa acccaggaag cctcagcctg     1080



aaggggcctg ttagtccacc tgctgcctta tctctttcaa ctcagtctct tcctgtggtg     1140



acctcttctc aaaagactgc gggtcccaac acccccccag attttcccat ttctctgggc     1200



tctcatcttg cacctttaca tcagagttct tttggttctg tccaactttt aggtcaaaca     1260



ggtcctagtg ctttgtcaga ccctacagtg aagaccattt ctgtagatca ttcttccaca     1320



ggggcctctt atccttctca gagatctgta attcctcccc ttccttccag aaatgaggta     1380



gttcctgcta ctgtggctgc ctttccagtg gtggctccat ctgttgacaa aggtccctct     1440



accatctcta gcataacctg cagcccttct ggctccttaa atgtagctac ctctttttca     1500



ttatctccta caacctctct cattctcaaa agctctccta atgccactta tcattatcct     1560



ttagtggccc aaatgcccgt ttcttctgtt ggaaccaccc cacttgtggt gactaacccc     1620



tgtacaattg ctgcagcacc tactactacc tttgaggtag ctacttgtgt ttctcctcca     1680



atgtcatcag gtcccataag taacatagaa ccaacttccc ctgctgcctt ggttatggca     1740



cctgtggctc ccaaagagcc ttctactcaa gtagcaacca ctctgaggat accagtctct     1800



cctcctctgc cagaccctga agacctcaaa aatctcccca gttcagtatt ggttaaattt     1860



ccaacacaaa aagacctcca aactgtacct gcctctcttg aaggagcccc tttctctcca     1920



gcccaagcag gactcaccac caagaaagac cctactgtat taccgttagt ccaggcagcc     1980



cctaaaaatt ccccttcttt ccaaagtaca tcctcttctc cagagatacc tctttctcct     2040



gaagccaccc tagcaaagaa aagccttggg gagcctctcc ctataggtaa gccagccagc     2100



agtatgacct cccctctggg tgttaactcc tcggcctctg taatcaagac agattcttat     2160



gcaggcccag actctgctgg tccgcttctc aaaagttctc tcattacccc aacagtggct     2220



gcatttcctt tggaaagtgc tgaccctgcc ggggtggctc ccacaactgc caaaggtacc     2280



tcaacttata caactacagc cagccctttt ctagaaggaa ctgtctcttt agctcctaaa     2340



aaccacccag ttaaggaagg tactcttact actttaccct tggttcctac agcttcagaa     2400



aattgccctg tggctccatc cccccagaat acctgtgctc ctctggctac cttagtgctg     2460



gcccctgaaa tcccaaagtc tgtgccctca ccctctcttc ccccagctgg gactcctcca     2520



ggtacaaaaa aggttgatgg tatttctcat acttcagcat tggcacctgt tgcttcctct     2580



cccaaagagt gcccaactga ggactctggt gcttctgcta ctgcatcttc caaaggaact     2640



ctgacttacc tagctgattc cccatctcct ttaggggtta gtgtgtctcc tcagactaaa     2700



agacctccaa ccaagaaggg ttctgctggc cctgatactc ctattggaaa tctctcatcc     2760



cctgtttctc cagttgaagc ttcatttctt ccagagaata gtctttcttt ccaaggctct     2820



aaagactcac cagccacgac gcattctccc actcctccat cccccaaagg ggcccctact     2880



ccctcagctg tgactcctct gtctcccaaa ggagtaacac taccccccaa agagaccccc     2940



actccttcag tggtgaatct gcccttcccc aaagagggtc cagctactcc agcacccaaa     3000



caggctcctg ctctatccat gacttcttcc tcccccaaaa aggcccgagc aactccagcc     3060



cctaaaggaa tcccagcttc cccatccccc aaaggggccc ccacaccccc agctgcaact     3120



cctccctccc ctaaaggagg cccagctacc ccatccccga aatgggcccc cacaccccca     3180



gctgcaactc ctccctcccc aaaaggaggt ccagctactc catcccccaa aggggccccc     3240



acacccccag ctgcaactcc tccctccccc aaaggaggtc cagctactcc atcccccaaa     3300



ggggccccca cacccccagc tgtgactcct ccctccccca aaggaagtcc agcagctacc     3360



ccattcccca aaggggcatc cacaccccca gctgcaactc ctccctcccc caaaggaagt     3420



ccagcagcta ccccactccc caaaggggcc cccacaaccc cagctgcaac tcttccctcc     3480



ccaaaaggag gtccagctac cccatccctc aagggggccc ccactccccc agctgcgact     3540



cctccctccc caaaaggagg cccagctacc ccatccccca aaggggcccc catgccccca     3600



gctgcaactc ctccctcccc aaaaggaggt ctagctaccc caccccacaa aggggcaccc     3660



acaaccccag ctgcaactcc tccctcccca aaaggaggtc tagctacccc acccccaaaa     3720



ggggccccca caaccccagc tgcaactcct ccttccccaa aaggaggtct agctacccca     3780



cccccaaaag gggcccccac aaccccagct gcaactcctc cttccccaaa aggaggtcta     3840



gctaccccat cccccaaagg ggcccccaca accccagctg caactcctcc ctccccaaaa     3900



ggaggtctag ctaccccatc ccccaaaggg gcccccacaa ccccagctgc aactcctccc     3960



tccccaaaag gaggtctggc taccccatcc cccaaagggg cccccacaac cccagctgca     4020



actcctccct ccccaaaagg aggcccagct accccacccc ccaaaggggc ccccactccc     4080



ccagctgcaa ctcctccctc cctaaaagga ggtctagcta ccccacccca caaaggggcc     4140



cccaatcccg cagttgtaac tcctccctct ccaaaaggag gcccagctac ctcacccccc     4200



aaaggggccc ccactcctcc agctgcaact cctccctccc caaaaggaag cccaggtacc     4260



ccacccccca aaggggcccc cactccccca gctgtaactc ctccctcccc taaagggacc     4320



cctactctcc cagctacaac tccctcctct aaaggaggcc caactactcc atcctccaaa     4380



gagggcccca ctcccccagc tgcaaccccc tcccacaaag gaggtcccgc tatgactcct     4440



ccctccccca aaagaggacc agctatccca tctcccaaag gggaccccac ttccccagca     4500



gtgattcctc tctcccccaa aaaggctcca gcaactccag tcaccagaga aggcgcagcc     4560



accccatcca aaggagatct cactccccca gcagtgactc ctgtctccct caaaaaggcc     4620



ccagcaactt cagcccccaa aggaggccca gctaccccat cctccaaagg ggatcccacc     4680



ctcccagcag tgactcctcc ttcccccaag gagcccccag cccccaaaca agttgccact     4740



tcttcctctc ccaaaaaggc cccagcaact ccagccccca tgggggcccc cactctgcca     4800



gctgtgattc cttcttcccc caaagaggtc ccagctaccc catcctccag aagggacccc     4860



attgccccaa cagcgactct tctctctaaa aagaccccag caactctagc ccccaaagag     4920



gccctcattc ccccagctat gactgttccc tcccctaaaa agaccccagc aattccaacc     4980



cccaaagaag ccccagctac cccatcctcc aaagaggcct ccagtccccc agcagtgact     5040



ccttccactt acaaaggggc cccatccccc aaagagctcc tcattccacc agctgtgact     5100



tctccttccc ccaaagaggc acctactcct ccagctgtga ctcctccatc ccccgaaaag     5160



ggcccagcaa ctccagcccc caaagggact cccacttccc cacctgtgac tccttcctcc     5220



ctcaaagact cccctacttc cccagcttct gtcacatgta aaatgggggc cactgttcct     5280



caagcatcta aagggcttcc agcaaagaaa ggccccacag ctctgaaaga agtacttgtt     5340



gccccagctc cagaaagcac gccaatcatc acagctccca ctcggaaagg tccacagacc     5400



aaaaagagtt ctgctacttc acctcctata tgcccagatc cctcagctaa gaatggttct     5460



aaaggacccc tttccacagt ggctccagcc cctctactcc ctgttcagaa agactcttca     5520



aagacagcaa aaggcaaaga tgcttctcat tccccaaagg gccccttggc tcctcctgag     5580



tctaaggcgt ccacccctct aacagcagct gcctttgaga aggtccttcc taaacctgaa     5640



tcagcatctg tctctgcagc accctcccca ccagtctctc tgcctcttgc tccctcccca     5700



gttcccactc tgcctcctaa acagcaattt ctgccgtcct ctcctgggct ggtgttggaa     5760



tcaccctcta aaccccttgc ccctgctgat gaggatgagc tgctgcctct gattcccccg     5820



gaaccaatct ctgggggagt gcctttccag tcggtcctcg tcaacatgcc cacccctaaa     5880



tctgctggaa tccctgtccc aaccccctct gccaagcaac ctgttacgaa gaacaacaag     5940



gggtctggaa cagaatctga cagtgatgaa tcagtaccag agcttgaaga acaggattcc     6000



acccaggcaa ccacacaaca agcccagctg gcggcagcag ctgaaattga tgaagaacca     6060



gtcagtaaag caaaacagag tcggagtgaa aagaaggcac ggaaggctat gtccaaactg     6120



ggtcttcggc aggttacagg agttactaga gtcactatcc ggaaatctaa gaatatcctc     6180



tttgtcatca caaaaccaga tgtctacaag agccctgctt cagatactta catagttttt     6240



ggggaagcca agatcgaaga tttatcccag caagcacaac tagcagctgc tgagaaattc     6300



aaagttcaag gtgaagctgt ctcaaacatt caagaaaaca cacagactcc aactgtacaa     6360



gaggagagtg aagaggaaga ggtcgatgaa acaggtgtag aagttaagga cattgaattg     6420



gtcatgtcac aagcaaatgt gtcgagagca aaggcagtcc gagccctgaa gaacaacagt     6480



aatgatattg taaatgcgat tatggaatta acaatgtaac catatggaag caactttttt     6540



tggtgtctca aaggagtaac tgcagcttgg tttgaaattt gtactgtttc tatcataaat     6600



aaagttatgg cttcttgttg gatgaattca aaaaaaaaaa aaaaaaaaaa                6650





<210>  159

<211>  2078

<212>  PRT

<213>  Homo sapiens



<400>  159



Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 

1               5                   10                  15      





Pro Gln Pro Gln Ala Glu Thr Ala Val Leu Pro Met Ser Ser Ala Leu 

            20                  25                  30          





Ser Val Thr Ala Ala Leu Gly Gln Pro Gly Pro Thr Leu Pro Pro Pro 

        35                  40                  45              





Cys Ser Pro Ala Pro Gln Gln Cys Pro Leu Ser Ala Ala Asn Gln Ala 

    50                  55                  60                  





Ser Pro Phe Pro Ser Pro Ser Thr Ile Ala Ser Thr Pro Leu Glu Val 

65                  70                  75                  80  





Pro Phe Pro Gln Ser Ser Ser Gly Thr Ala Leu Pro Leu Gly Thr Ala 

                85                  90                  95      





Pro Glu Ala Pro Thr Phe Leu Pro Asn Leu Ile Gly Pro Pro Ile Ser 

            100                 105                 110         





Pro Ala Ala Leu Ala Leu Ala Ser Pro Met Ile Ala Pro Thr Leu Lys 

        115                 120                 125             





Gly Thr Pro Ser Ser Ser Ala Pro Leu Ala Leu Val Ala Leu Ala Pro 

    130                 135                 140                 





His Ser Val Gln Lys Ser Ser Ala Phe Pro Pro Asn Leu Leu Thr Ser 

145                 150                 155                 160 





Pro Pro Ser Val Ala Val Ala Glu Ser Gly Ser Val Ile Thr Leu Ser 

                165                 170                 175     





Ala Pro Ile Ala Pro Ser Glu Pro Lys Thr Asn Leu Asn Lys Val Pro 

            180                 185                 190         





Ser Glu Val Val Pro Asn Pro Lys Gly Thr Pro Ser Pro Pro Cys Ile 

        195                 200                 205             





Val Ser Thr Val Pro Tyr His Cys Val Thr Pro Met Ala Ser Ile Gln 

    210                 215                 220                 





Ser Gly Val Ala Ser Leu Pro Gln Thr Thr Pro Thr Thr Thr Leu Ala 

225                 230                 235                 240 





Ile Ala Ser Pro Gln Val Lys Asp Thr Thr Ile Ser Ser Val Leu Ile 

                245                 250                 255     





Ser Pro Gln Asn Pro Gly Ser Leu Ser Leu Lys Gly Pro Val Ser Pro 

            260                 265                 270         





Pro Ala Ala Leu Ser Leu Ser Thr Gln Ser Leu Pro Val Val Thr Ser 

        275                 280                 285             





Ser Gln Lys Thr Ala Gly Pro Asn Thr Pro Pro Asp Phe Pro Ile Ser 

    290                 295                 300                 





Leu Gly Ser His Leu Ala Pro Leu His Gln Ser Ser Phe Gly Ser Val 

305                 310                 315                 320 





Gln Leu Leu Gly Gln Thr Gly Pro Ser Ala Leu Ser Asp Pro Thr Val 

                325                 330                 335     





Lys Thr Ile Ser Val Asp His Ser Ser Thr Gly Ala Ser Tyr Pro Ser 

            340                 345                 350         





Gln Arg Ser Val Ile Pro Pro Leu Pro Ser Arg Asn Glu Val Val Pro 

        355                 360                 365             





Ala Thr Val Ala Ala Phe Pro Val Val Ala Pro Ser Val Asp Lys Gly 

    370                 375                 380                 





Pro Ser Thr Ile Ser Ser Ile Thr Cys Ser Pro Ser Gly Ser Leu Asn 

385                 390                 395                 400 





Val Ala Thr Ser Phe Ser Leu Ser Pro Thr Thr Ser Leu Ile Leu Lys 

                405                 410                 415     





Ser Ser Pro Asn Ala Thr Tyr His Tyr Pro Leu Val Ala Gln Met Pro 

            420                 425                 430         





Val Ser Ser Val Gly Thr Thr Pro Leu Val Val Thr Asn Pro Cys Thr 

        435                 440                 445             





Ile Ala Ala Ala Pro Thr Thr Thr Phe Glu Val Ala Thr Cys Val Ser 

    450                 455                 460                 





Pro Pro Met Ser Ser Gly Pro Ile Ser Asn Ile Glu Pro Thr Ser Pro 

465                 470                 475                 480 





Ala Ala Leu Val Met Ala Pro Val Ala Pro Lys Glu Pro Ser Thr Gln 

                485                 490                 495     





Val Ala Thr Thr Leu Arg Ile Pro Val Ser Pro Pro Leu Pro Asp Pro 

            500                 505                 510         





Glu Asp Leu Lys Asn Leu Pro Ser Ser Val Leu Val Lys Phe Pro Thr 

        515                 520                 525             





Gln Lys Asp Leu Gln Thr Val Pro Ala Ser Leu Glu Gly Ala Pro Phe 

    530                 535                 540                 





Ser Pro Ala Gln Ala Gly Leu Thr Thr Lys Lys Asp Pro Thr Val Leu 

545                 550                 555                 560 





Pro Leu Val Gln Ala Ala Pro Lys Asn Ser Pro Ser Phe Gln Ser Thr 

                565                 570                 575     





Ser Ser Ser Pro Glu Ile Pro Leu Ser Pro Glu Ala Thr Leu Ala Lys 

            580                 585                 590         





Lys Ser Leu Gly Glu Pro Leu Pro Ile Gly Lys Pro Ala Ser Ser Met 

        595                 600                 605             





Thr Ser Pro Leu Gly Val Asn Ser Ser Ala Ser Val Ile Lys Thr Asp 

    610                 615                 620                 





Ser Tyr Ala Gly Pro Asp Ser Ala Gly Pro Leu Leu Lys Ser Ser Leu 

625                 630                 635                 640 





Ile Thr Pro Thr Val Ala Ala Phe Pro Leu Glu Ser Ala Asp Pro Ala 

                645                 650                 655     





Gly Val Ala Pro Thr Thr Ala Lys Gly Thr Ser Thr Tyr Thr Thr Thr 

            660                 665                 670         





Ala Ser Pro Phe Leu Glu Gly Thr Val Ser Leu Ala Pro Lys Asn His 

        675                 680                 685             





Pro Val Lys Glu Gly Thr Leu Thr Thr Leu Pro Leu Val Pro Thr Ala 

    690                 695                 700                 





Ser Glu Asn Cys Pro Val Ala Pro Ser Pro Gln Asn Thr Cys Ala Pro 

705                 710                 715                 720 





Leu Ala Thr Leu Val Leu Ala Pro Glu Ile Pro Lys Ser Val Pro Ser 

                725                 730                 735     





Pro Ser Leu Pro Pro Ala Gly Thr Pro Pro Gly Thr Lys Lys Val Asp 

            740                 745                 750         





Gly Ile Ser His Thr Ser Ala Leu Ala Pro Val Ala Ser Ser Pro Lys 

        755                 760                 765             





Glu Cys Pro Thr Glu Asp Ser Gly Ala Ser Ala Thr Ala Ser Ser Lys 

    770                 775                 780                 





Gly Thr Leu Thr Tyr Leu Ala Asp Ser Pro Ser Pro Leu Gly Val Ser 

785                 790                 795                 800 





Val Ser Pro Gln Thr Lys Arg Pro Pro Thr Lys Lys Gly Ser Ala Gly 

                805                 810                 815     





Pro Asp Thr Pro Ile Gly Asn Leu Ser Ser Pro Val Ser Pro Val Glu 

            820                 825                 830         





Ala Ser Phe Leu Pro Glu Asn Ser Leu Ser Phe Gln Gly Ser Lys Asp 

        835                 840                 845             





Ser Pro Ala Thr Thr His Ser Pro Thr Pro Pro Ser Pro Lys Gly Ala 

    850                 855                 860                 





Pro Thr Pro Ser Ala Val Thr Pro Leu Ser Pro Lys Gly Val Thr Leu 

865                 870                 875                 880 





Pro Pro Lys Glu Thr Pro Thr Pro Ser Val Val Asn Leu Pro Phe Pro 

                885                 890                 895     





Lys Glu Gly Pro Ala Thr Pro Ala Pro Lys Gln Ala Pro Ala Leu Ser 

            900                 905                 910         





Met Thr Ser Ser Ser Pro Lys Lys Ala Arg Ala Thr Pro Ala Pro Lys 

        915                 920                 925             





Gly Ile Pro Ala Ser Pro Ser Pro Lys Gly Ala Pro Thr Pro Pro Ala 

    930                 935                 940                 





Ala Thr Pro Pro Ser Pro Lys Gly Gly Pro Ala Thr Pro Ser Pro Lys 

945                 950                 955                 960 





Trp Ala Pro Thr Pro Pro Ala Ala Thr Pro Pro Ser Pro Lys Gly Gly 

                965                 970                 975     





Pro Ala Thr Pro Ser Pro Lys Gly Ala Pro Thr Pro Pro Ala Ala Thr 

            980                 985                 990         





Pro Pro Ser Pro Lys Gly Gly Pro  Ala Thr Pro Ser Pro  Lys Gly Ala 

        995                 1000                 1005             





Pro Thr  Pro Pro Ala Val Thr  Pro Pro Ser Pro Lys  Gly Ser Pro 

    1010                 1015                 1020             





Ala Ala  Thr Pro Phe Pro Lys  Gly Ala Ser Thr Pro  Pro Ala Ala 

    1025                 1030                 1035             





Thr Pro  Pro Ser Pro Lys Gly  Ser Pro Ala Ala Thr  Pro Leu Pro 

    1040                 1045                 1050             





Lys Gly  Ala Pro Thr Thr Pro  Ala Ala Thr Leu Pro  Ser Pro Lys 

    1055                 1060                 1065             





Gly Gly  Pro Ala Thr Pro Ser  Leu Lys Gly Ala Pro  Thr Pro Pro 

    1070                 1075                 1080             





Ala Ala  Thr Pro Pro Ser Pro  Lys Gly Gly Pro Ala  Thr Pro Ser 

    1085                 1090                 1095             





Pro Lys  Gly Ala Pro Met Pro  Pro Ala Ala Thr Pro  Pro Ser Pro 

    1100                 1105                 1110             





Lys Gly  Gly Leu Ala Thr Pro  Pro His Lys Gly Ala  Pro Thr Thr 

    1115                 1120                 1125             





Pro Ala  Ala Thr Pro Pro Ser  Pro Lys Gly Gly Leu  Ala Thr Pro 

    1130                 1135                 1140             





Pro Pro  Lys Gly Ala Pro Thr  Thr Pro Ala Ala Thr  Pro Pro Ser 

    1145                 1150                 1155             





Pro Lys  Gly Gly Leu Ala Thr  Pro Pro Pro Lys Gly  Ala Pro Thr 

    1160                 1165                 1170             





Thr Pro  Ala Ala Thr Pro Pro  Ser Pro Lys Gly Gly  Leu Ala Thr 

    1175                 1180                 1185             





Pro Ser  Pro Lys Gly Ala Pro  Thr Thr Pro Ala Ala  Thr Pro Pro 

    1190                 1195                 1200             





Ser Pro  Lys Gly Gly Leu Ala  Thr Pro Ser Pro Lys  Gly Ala Pro 

    1205                 1210                 1215             





Thr Thr  Pro Ala Ala Thr Pro  Pro Ser Pro Lys Gly  Gly Leu Ala 

    1220                 1225                 1230             





Thr Pro  Ser Pro Lys Gly Ala  Pro Thr Thr Pro Ala  Ala Thr Pro 

    1235                 1240                 1245             





Pro Ser  Pro Lys Gly Gly Pro  Ala Thr Pro Pro Pro  Lys Gly Ala 

    1250                 1255                 1260             





Pro Thr  Pro Pro Ala Ala Thr  Pro Pro Ser Leu Lys  Gly Gly Leu 

    1265                 1270                 1275             





Ala Thr  Pro Pro His Lys Gly  Ala Pro Asn Pro Ala  Val Val Thr 

    1280                 1285                 1290             





Pro Pro  Ser Pro Lys Gly Gly  Pro Ala Thr Ser Pro  Pro Lys Gly 

    1295                 1300                 1305             





Ala Pro  Thr Pro Pro Ala Ala  Thr Pro Pro Ser Pro  Lys Gly Ser 

    1310                 1315                 1320             





Pro Gly  Thr Pro Pro Pro Lys  Gly Ala Pro Thr Pro  Pro Ala Val 

    1325                 1330                 1335             





Thr Pro  Pro Ser Pro Lys Gly  Thr Pro Thr Leu Pro  Ala Thr Thr 

    1340                 1345                 1350             





Pro Ser  Ser Lys Gly Gly Pro  Thr Thr Pro Ser Ser  Lys Glu Gly 

    1355                 1360                 1365             





Pro Thr  Pro Pro Ala Ala Thr  Pro Ser His Lys Gly  Gly Pro Ala 

    1370                 1375                 1380             





Met Thr  Pro Pro Ser Pro Lys  Arg Gly Pro Ala Ile  Pro Ser Pro 

    1385                 1390                 1395             





Lys Gly  Asp Pro Thr Ser Pro  Ala Val Ile Pro Leu  Ser Pro Lys 

    1400                 1405                 1410             





Lys Ala  Pro Ala Thr Pro Val  Thr Arg Glu Gly Ala  Ala Thr Pro 

    1415                 1420                 1425             





Ser Lys  Gly Asp Leu Thr Pro  Pro Ala Val Thr Pro  Val Ser Leu 

    1430                 1435                 1440             





Lys Lys  Ala Pro Ala Thr Ser  Ala Pro Lys Gly Gly  Pro Ala Thr 

    1445                 1450                 1455             





Pro Ser  Ser Lys Gly Asp Pro  Thr Leu Pro Ala Val  Thr Pro Pro 

    1460                 1465                 1470             





Ser Pro  Lys Glu Pro Pro Ala  Pro Lys Gln Val Ala  Thr Ser Ser 

    1475                 1480                 1485             





Ser Pro  Lys Lys Ala Pro Ala  Thr Pro Ala Pro Met  Gly Ala Pro 

    1490                 1495                 1500             





Thr Leu  Pro Ala Val Ile Pro  Ser Ser Pro Lys Glu  Val Pro Ala 

    1505                 1510                 1515             





Thr Pro  Ser Ser Arg Arg Asp  Pro Ile Ala Pro Thr  Ala Thr Leu 

    1520                 1525                 1530             





Leu Ser  Lys Lys Thr Pro Ala  Thr Leu Ala Pro Lys  Glu Ala Leu 

    1535                 1540                 1545             





Ile Pro  Pro Ala Met Thr Val  Pro Ser Pro Lys Lys  Thr Pro Ala 

    1550                 1555                 1560             





Ile Pro  Thr Pro Lys Glu Ala  Pro Ala Thr Pro Ser  Ser Lys Glu 

    1565                 1570                 1575             





Ala Ser  Ser Pro Pro Ala Val  Thr Pro Ser Thr Tyr  Lys Gly Ala 

    1580                 1585                 1590             





Pro Ser  Pro Lys Glu Leu Leu  Ile Pro Pro Ala Val  Thr Ser Pro 

    1595                 1600                 1605             





Ser Pro  Lys Glu Ala Pro Thr  Pro Pro Ala Val Thr  Pro Pro Ser 

    1610                 1615                 1620             





Pro Glu  Lys Gly Pro Ala Thr  Pro Ala Pro Lys Gly  Thr Pro Thr 

    1625                 1630                 1635             





Ser Pro  Pro Val Thr Pro Ser  Ser Leu Lys Asp Ser  Pro Thr Ser 

    1640                 1645                 1650             





Pro Ala  Ser Val Thr Cys Lys  Met Gly Ala Thr Val  Pro Gln Ala 

    1655                 1660                 1665             





Ser Lys  Gly Leu Pro Ala Lys  Lys Gly Pro Thr Ala  Leu Lys Glu 

    1670                 1675                 1680             





Val Leu  Val Ala Pro Ala Pro  Glu Ser Thr Pro Ile  Ile Thr Ala 

    1685                 1690                 1695             





Pro Thr  Arg Lys Gly Pro Gln  Thr Lys Lys Ser Ser  Ala Thr Ser 

    1700                 1705                 1710             





Pro Pro  Ile Cys Pro Asp Pro  Ser Ala Lys Asn Gly  Ser Lys Gly 

    1715                 1720                 1725             





Pro Leu  Ser Thr Val Ala Pro  Ala Pro Leu Leu Pro  Val Gln Lys 

    1730                 1735                 1740             





Asp Ser  Ser Lys Thr Ala Lys  Gly Lys Asp Ala Ser  His Ser Pro 

    1745                 1750                 1755             





Lys Gly  Pro Leu Ala Pro Pro  Glu Ser Lys Ala Ser  Thr Pro Leu 

    1760                 1765                 1770             





Thr Ala  Ala Ala Phe Glu Lys  Val Leu Pro Lys Pro  Glu Ser Ala 

    1775                 1780                 1785             





Ser Val  Ser Ala Ala Pro Ser  Pro Pro Val Ser Leu  Pro Leu Ala 

    1790                 1795                 1800             





Pro Ser  Pro Val Pro Thr Leu  Pro Pro Lys Gln Gln  Phe Leu Pro 

    1805                 1810                 1815             





Ser Ser  Pro Gly Leu Val Leu  Glu Ser Pro Ser Lys  Pro Leu Ala 

    1820                 1825                 1830             





Pro Ala  Asp Glu Asp Glu Leu  Leu Pro Leu Ile Pro  Pro Glu Pro 

    1835                 1840                 1845             





Ile Ser  Gly Gly Val Pro Phe  Gln Ser Val Leu Val  Asn Met Pro 

    1850                 1855                 1860             





Thr Pro  Lys Ser Ala Gly Ile  Pro Val Pro Thr Pro  Ser Ala Lys 

    1865                 1870                 1875             





Gln Pro  Val Thr Lys Asn Asn  Lys Gly Ser Gly Thr  Glu Ser Asp 

    1880                 1885                 1890             





Ser Asp  Glu Ser Val Pro Glu  Leu Glu Glu Gln Asp  Ser Thr Gln 

    1895                 1900                 1905             





Ala Thr  Thr Gln Gln Ala Gln  Leu Ala Ala Ala Ala  Glu Ile Asp 

    1910                 1915                 1920             





Glu Glu  Pro Val Ser Lys Ala  Lys Gln Ser Arg Ser  Glu Lys Lys 

    1925                 1930                 1935             





Ala Arg  Lys Ala Met Ser Lys  Leu Gly Leu Arg Gln  Val Thr Gly 

    1940                 1945                 1950             





Val Thr  Arg Val Thr Ile Arg  Lys Ser Lys Asn Ile  Leu Phe Val 

    1955                 1960                 1965             





Ile Thr  Lys Pro Asp Val Tyr  Lys Ser Pro Ala Ser  Asp Thr Tyr 

    1970                 1975                 1980             





Ile Val  Phe Gly Glu Ala Lys  Ile Glu Asp Leu Ser  Gln Gln Ala 

    1985                 1990                 1995             





Gln Leu  Ala Ala Ala Glu Lys  Phe Lys Val Gln Gly  Glu Ala Val 

    2000                 2005                 2010             





Ser Asn  Ile Gln Glu Asn Thr  Gln Thr Pro Thr Val  Gln Glu Glu 

    2015                 2020                 2025             





Ser Glu  Glu Glu Glu Val Asp  Glu Thr Gly Val Glu  Val Lys Asp 

    2030                 2035                 2040             





Ile Glu  Leu Val Met Ser Gln  Ala Asn Val Ser Arg  Ala Lys Ala 

    2045                 2050                 2055             





Val Arg  Ala Leu Lys Asn Asn  Ser Asn Asp Ile Val  Asn Ala Ile 

    2060                 2065                 2070             





Met Glu  Leu Thr Met 

    2075             





<210>  160

<211>  1102

<212>  DNA

<213>  Homo sapiens



<400>  160

ggttccgcgt tccctgcaca gtaagtactt tctgtgccgc tactgtctat ccgcagccat       60



ccgcctttct ttcgggctaa gccgccccgg ggactgagag ttaaggagag ttggaggctt      120



tactgggcca cagggttcct actcgcccct gggcctccgg acaaaatggg gtctgcggtt      180



ggtgtcctgg caaaagcagg gtagaagggc tgcggggcgg gcccagaatc cgagcctgca      240



gagatgggag cagttgcagt gttgagggcg gaagaggagt gcgtcttgtt ttgggaactg      300



cttcacagga tccagaaaag gaaatgcccg gcgaagccac agaaaccgtc cctgctacag      360



agcaggagtt gccgcagccc caggctgaga cagggtctgg aacagaatct gacagtgatg      420



aatcagtacc agagcttgaa gaacaggatt ccacccaggc aaccacacaa caagcccagc      480



tggcggcagc agctgaaatt gatgaagaac cagtcagtaa agcaaaacag agtcggagtg      540



aaaagaaggc acggaaggct atgtccaaac tgggtcttcg gcaggttaca ggagttacta      600



gagtcactat ccggaaatct aagaatatcc tctttgtcat cacaaaacca gatgtctaca      660



agagccctgc ttcagatact tacatagttt ttggggaagc caagatcgaa gatttatccc      720



agcaagcaca actagcagct gctgagaaat tcaaagttca aggtgaagct gtctcaaaca      780



ttcaagaaaa cacacagact ccaactgtac aagaggagag tgaagaggaa gaggtcgatg      840



aaacaggtgt agaagttaag gacattgaat tggtcatgtc acaagcaaat gtgtcgagag      900



caaaggcagt ccgagccctg aagaacaaca gtaatgatat tgtaaatgcg attatggaat      960



taacaatgta accatatgga agcaactttt tttggtgtct caaaggagta actgcagctt     1020



ggtttgaaat ttgtactgtt tctatcataa ataaagttat ggcttcttgt tggatgaatt     1080



caaaaaaaaa aaaaaaaaaa aa                                              1102





<210>  161

<211>  215

<212>  PRT

<213>  Homo sapiens



<400>  161



Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 

1               5                   10                  15      





Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp 

            20                  25                  30          





Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr 

        35                  40                  45              





Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 

    50                  55                  60                  





Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 

65                  70                  75                  80  





Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile 

                85                  90                  95      





Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr 

            100                 105                 110         





Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile 

        115                 120                 125             





Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 

    130                 135                 140                 





Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro 

145                 150                 155                 160 





Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 

                165                 170                 175     





Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg 

            180                 185                 190         





Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 

        195                 200                 205             





Ala Ile Met Glu Leu Thr Met 

    210                 215 





<210>  162

<211>  5125

<212>  DNA

<213>  Homo sapiens



<400>  162

aaaagatatg gtggggtgct taacagagga ggttagacac cggcgggaac cagaggagcc       60



caagcgcggc gcctgggcct cggggctgca ggagtcctcg gtgggggtat ggaggtcgcc      120



ggggaaggag gacggttcag ttgctaggca acccggcctg gacccgcctc tcgctcgcgt      180



tgctgggaga ctacaaggcc gggaggaggg cggcgaaagg gccctacgtg ctgacgctaa      240



ttgtatatga gcgcgagcgg cgggctcttg ggtctttttt agcgccatct gctcgcggcg      300



ccgcctcctg ctcctcccgc tgctgctgcc gctgccgccc tgagtcactg cctgcgcagc      360



tccggccgcc tggctcccca tactagtcgc cgatatttgg agttcttaca acatggcaga      420



cattgacaac aaagaacagt ctgaacttga tcaagatttg gatgatgttg aagaagtaga      480



agaagaggaa actggtgaag aaacaaaact caaagcacgt cagctaactg ttcagatgat      540



gcaaaatcct cagattcttg cagcccttca agaaagactt gatggtctgg tagaaacacc      600



aacaggatac attgaaagcc tgcctagggt agttaaaaga cgagtgaatg ctctcaaaaa      660



cctgcaagtt aaatgtgcac agatagaagc caaattctat gaggaagttc acgatcttga      720



aaggaagtat gctgttctct atcagcctct atttgataag cgatttgaaa ttattaatgc      780



aatttatgaa cctacggaag aagaatgtga atggaaacca gatgaagaag atgagatttc      840



ggaggaattg aaagaaaagg ccaagattga agatgagaaa aaagatgaag aaaaagaaga      900



ccccaaagga attcctgaat tttggttaac tgtttttaag aatgttgact tgctcagtga      960



tatggttcag gaacacgatg aacctattct gaagcacttg aaagatatta aagtgaagtt     1020



ctcagatgct ggccagccta tgagttttgt cttagaattt cactttgaac ccaatgaata     1080



ttttacaaat gaagtgctga caaagacata caggatgagg tcagaaccag atgattctga     1140



tcccttttct tttgatggac cagaaattat gggttgtaca gggtgccaga tagattggaa     1200



aaaaggaaag aatgtcactt tgaaaactat taagaagaag cagaaacaca agggacgtgg     1260



gacagttcgt actgtgacta aaacagtttc caatgactct ttctttaact tttttgcccc     1320



tcctgaagtt cctgagagtg gagatctgga tgatgatgct gaagctatcc ttgctgcaga     1380



cttcgaaatt ggtcactttt tacgtgagcg tataatccca agatcagtgt tatattttac     1440



tggagaagct attgaagatg atgatgatga ttatgatgaa gaaggtgaag aagcggatga     1500



ggaaggggaa gaagaaggag atgaggaaaa tgatccagac tatgacccaa agaaggatca     1560



aaacccagca gagtgcaagc agcagtgaag caggatgtat gtggccttga ggataacctg     1620



cactgtaata gcctaaacac aactcttatt tacttacagc cttatgtttt tgtattttct     1680



tggtagacta ggtaattttt ttttaaagga caggaaactg atattttaaa gaccaatttg     1740



ttctacctag cattttaact agtttttctg ccagctatgt tgaatgcaca aattctgtca     1800



cgcatgttca ttcattgcta cataatttgg ttcttctgga atatttttat gtagctcttg     1860



gagtacagct atgaaaatta acaactgtta aaggaaatac cttttttttt tttttgtaat     1920



tttttccttg aagaaccaaa gtattttttc agctggttgt tgaatagggt taagtccgct     1980



tggattagct gtgcctttca ttactttgtt acagaaatgc agtgacttat actaagacaa     2040



tttattgttt aaaaaaaaaa ttggcaagac aactatatgg ttaagaattt ccagtatgac     2100



cacacccaat aactgttatt agagtgttaa tggattattg tgttttaggt gacatagtta     2160



actgtaaagt aacctgactc agtatagtta ctggtaccac agtgaggtga ataaaacggg     2220



attttcagaa gttagcctga atttaactgt atttttaaat ttaacctcca ttaactaagc     2280



atcttttctt tgtggtaggg tctaccttct gcttccctgg aaaggatgaa tttacatcat     2340



ttgacaagcc tattttcaag ttatttgttg tttgtttgct tgtttttgtt tttgcagcta     2400



aaataaaaat ttcaaataca attttagttc ttacaagata atgtcttaat tttgtaccaa     2460



ttcaggtaga agtagaggcc taccttgaat taagggttat actcagtttt taacacattg     2520



ttgaagaaaa ggtaccagct ttggaacgag atgctatact aataagcaag tgtaaaaaaa     2580



aaaaaaaaag aggaagaaaa tcttaagtga ttgatgctgt tttcttttaa aaaaaaaaaa     2640



aaaaattcat tttctttggg ttagagctag agagaaggcc ccaagcttct atggtttctt     2700



ctaattctta ttgcttaaag tatgagtatg tcacttaccc gtgcttctgt ttactgtgta     2760



attaaaatgg gtagtactgt ttacctaact acctcatgga tgtgttaagg catattgagt     2820



taaatctcat ataatgtttc tcaatcttgt taaaagctca aaattttggg cctatttgta     2880



atgccagtgt gacactaagc attttgttca caccacgctt tgataactaa actggaaaac     2940



aaaggtgtta agtacctctg ttctggatct gggcagtcag cactcttttt agatctttgt     3000



gtggctccta tttttataga agtggaggga tgcactattt cacaaggtcc aagatttgtt     3060



ttcagatatt tttgatgact gtattgtaaa tactacaggg atagcactat agtattgtag     3120



tcatgagact taaagtggaa ataagactat ttttgacaaa agatgccatt aaatttcaga     3180



ctgtagagcc acatttacaa tacctcaggc taattactgt taattttggg gttgaacttt     3240



tttttgacag tgagggtgga ttattggatt gtcattagag gaaggtctag atttcctgct     3300



cttaataaaa ttacattgaa ttgattttta gaggtaatga aaacttcctt tctgagaagt     3360



tagtgttaag gtcttggaat gtgaacacat tgtttgtagt gctatccatt cctctcctga     3420



gattttaact tactactgga aatccttaac caattataat agcttttttt ctttattttc     3480



aaaatgattt cctttgcttt gattagacac tatgtgcttt ttttttttaa ccatagttca     3540



tcgaaatgca gctttttctg aacttcaaag atagaatccc atttttaatg aactgaagta     3600



gcaaaatcat ctttttcatt ctttaggaaa tagctattgc caaagtgaag gtgtagataa     3660



tacctagtct tgttacataa aggggatgtg gtttgcagaa gaattttctt tataaaattg     3720



aagttttaag ggacgtcagt gtttatgcca tttttccagt tccaaaatga ttccattcca     3780



ttctagaaat ttgaagtatg taacctgaaa tccttaataa aatttggatt taattttata     3840



aaatgtactg gtgatatttt gggtgttttt ttttaaatga atgtatatac tttttttttg     3900



aagagtggag agtagtgatg tctagaggga gctattttgt gctgaggcca ctatgttctg     3960



taaatatata attttaagag caacctcaca atccctgcta agtggagttt attatttgaa     4020



gactaaaatg gaattccata gttcctgata ggttatattc tgggttatta ttctgagtta     4080



tctacaaaca tttttgagat ttgtctttac actctgattg tagtttccag cagcccatgc     4140



acactgccaa gtaagtctca ttttttcctg ttagaaatgg tgaaatatca tataatcact     4200



tataaagaaa actgatatga aaaaatttta gagttgtttg ctttatggtc actcaagtag     4260



ggtaagtgtt ccacaaattc cacaagttga tagtttaaca tggatgtctg aaagccacat     4320



atataatttc ttaggattct taaattagta aatctagctt actgaagcag tattagcatc     4380



actattttag attgcaaaaa taccttaatt gtgtggaact ggcttgtaga gtggtactta     4440



agaaaaatgg gattctacct ctatttctgt tttagcacac ttaatcagga aaggatatat     4500



taactttcat aaaaatattt ttgttgtgtg aataggttaa tgatatggta aggcccctaa     4560



aataactgaa ttaattgttt attgtaattg taggccattc ccattattaa aaataaagac     4620



aaaacttgaa gtaactgaaa atcttatcgt gctatgtaga aatattgaac taatattcaa     4680



atatttgaat gctttggttt cagggattgg tttaaaattg gagtcctttt ttatgggtta     4740



gtcttacaaa aatttaagcc tttatatttt tgactttaaa tcaaaacaaa tgttatttta     4800



aatgtacaga atagattggt agtgcagaag agtgtaagtt cttcatagga gctttagaaa     4860



agagaaatat gtgctaattc agtttttttt taatctgcac tgtacatata tacttggtaa     4920



ttatgagctt gattttgttt ttggaaatat gtgttcataa tttaggtaat ttgctactta     4980



aagcactaag tctctgatac ctgaaaagta catgtaaatg gtgatggtga aataatactg     5040



cagttaactt aatagatgta tactggtgat ttttgtatgc tggattaaaa ctccagatat     5100



taaaatataa cctggataaa aagcc                                           5125





<210>  163

<211>  391

<212>  PRT

<213>  Homo sapiens



<400>  163



Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 

1               5                   10                  15      





Asp Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 

            20                  25                  30          





Leu Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 

        35                  40                  45              





Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Glu Thr Pro Thr 

    50                  55                  60                  





Gly Tyr Ile Glu Ser Leu Pro Arg Val Val Lys Arg Arg Val Asn Ala 

65                  70                  75                  80  





Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 

                85                  90                  95      





Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 

            100                 105                 110         





Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 

        115                 120                 125             





Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser Glu 

    130                 135                 140                 





Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 

145                 150                 155                 160 





Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 

                165                 170                 175     





Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile 

            180                 185                 190         





Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln 

        195                 200                 205             





Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe 

    210                 215                 220                 





Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp 

225                 230                 235                 240 





Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr 

                245                 250                 255     





Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr 

            260                 265                 270         





Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val 

        275                 280                 285             





Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro Pro 

    290                 295                 300                 





Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile Leu 

305                 310                 315                 320 





Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro 

                325                 330                 335     





Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp 

            340                 345                 350         





Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu 

        355                 360                 365             





Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn 

    370                 375                 380                 





Pro Ala Glu Cys Lys Gln Gln 

385                 390     





<210>  164

<211>  4451

<212>  DNA

<213>  Homo sapiens



<400>  164

aaaagatatg gtggggtgct taacagagga ggttagacac cggcgggaac cagaggagcc       60



caagcgcggc gcctgggcct cggggctgca ggagtcctcg gtgggggtat ggaggtcgcc      120



ggggaaggag gacggttcag ttgctaggca acccggcctg gacccgcctc tcgctcgcgt      180



tgctgggaga ctacaaggcc gggaggaggg cggcgaaagg gccctacgtg ctgacgctaa      240



ttgtatatga gcgcgagcgg cgggctcttg ggtctttttt agcgccatct gctcgcggcg      300



ccgcctcctg ctcctcccgc tgctgctgcc gctgccgccc tgagtcactg cctgcgcagc      360



tccggccgcc tggctcccca tactagtcgc cgatatttgg agttcttaca acatggcaga      420



cattgacaac aaagaacagt ctgaacttga tcaagatttg gatgatgttg aagaagtaga      480



agaagaggaa actggtgaag aaacaaaact caaagcacgt cagctaactg ttcagatgat      540



gcaaaatcct cagattcttg cagcccttca agaaagactt gatggtctgg tagaaacacc      600



aacaggatac attgaaagcc tgcctagggt agttaaaaga cgagtgaatg ctctcaaaaa      660



cctgcaagtt aaatgtgcac agatagaagc caaattctat gaggaagttc acgatcttga      720



aaggaagtat gctgttctct atcagcctct atttgataag cgatttgaaa ttattaatgc      780



aatttatgaa cctacggaag aagaatgtga atggaaacca gatgaagaag atgagatttc      840



ggaggaattg aaagaaaagg ccaagattga agatgagaaa aaagatgaag aaaaagaaga      900



ccccaaagga attcctgaat tttggttaac tgtttttaag aatgttgact tgctcagtga      960



tatggttcag gaacacgatg aacctattct gaagcacttg aaagatatta aagtgaagtt     1020



ctcagatgct ggccagccta tgagttttgt cttagaattt cactttgaac ccaatgaata     1080



ttttacaaat gaagtgctga caaagacata caggatgagg tcagaaccag atgattctga     1140



tcccttttct tttgatggac cagaaattat gggttgtaca gggtgccaga tagattggaa     1200



aaaaggaaag aatgtcactt tgaaaactat taagaagaag cagaaacaca agggacgtgg     1260



gacagttcgt actgtgacta aaacagtttc caatgactct ttctttaact tttttgcccc     1320



tcctgaagtt cctgagagtg gagatctgga tgatgatgct gaagctatcc ttgctgcaga     1380



cttcgaaatt ggtcactttt tacgtgagcg tataatccca agatcagtgt tatattttac     1440



tggagaagct attgaagatg atgatgatga ttatgatgaa gaaggtgaag aagcggatga     1500



ggaaggggaa gaagaaggag atgaggaaaa tgatccagac tatgacccaa agaaggatca     1560



aaacccagca gagtgcaagc agcagtgaag caggatgtat gtggccttga ggataacctg     1620



cactggtcta ccttctgctt ccctggaaag gatgaattta catcatttga caagcctatt     1680



ttcaagttat ttgttgtttg tttgcttgtt tttgtttttg cagctaaaat aaaaatttca     1740



aatacaattt tagttcttac aagataatgt cttaattttg taccaattca ggtagaagta     1800



gaggcctacc ttgaattaag ggttatactc agtttttaac acattgttga agaaaaggta     1860



ccagctttgg aacgagatgc tatactaata agcaagtgta aaaaaaaaaa aaaaagagga     1920



agaaaatctt aagtgattga tgctgttttc ttttaaaaaa aaaaaaaaaa attcattttc     1980



tttgggttag agctagagag aaggccccaa gcttctatgg tttcttctaa ttcttattgc     2040



ttaaagtatg agtatgtcac ttacccgtgc ttctgtttac tgtgtaatta aaatgggtag     2100



tactgtttac ctaactacct catggatgtg ttaaggcata ttgagttaaa tctcatataa     2160



tgtttctcaa tcttgttaaa agctcaaaat tttgggccta tttgtaatgc cagtgtgaca     2220



ctaagcattt tgttcacacc acgctttgat aactaaactg gaaaacaaag gtgttaagta     2280



cctctgttct ggatctgggc agtcagcact ctttttagat ctttgtgtgg ctcctatttt     2340



tatagaagtg gagggatgca ctatttcaca aggtccaaga tttgttttca gatatttttg     2400



atgactgtat tgtaaatact acagggatag cactatagta ttgtagtcat gagacttaaa     2460



gtggaaataa gactattttt gacaaaagat gccattaaat ttcagactgt agagccacat     2520



ttacaatacc tcaggctaat tactgttaat tttggggttg aacttttttt tgacagtgag     2580



ggtggattat tggattgtca ttagaggaag gtctagattt cctgctctta ataaaattac     2640



attgaattga tttttagagg taatgaaaac ttcctttctg agaagttagt gttaaggtct     2700



tggaatgtga acacattgtt tgtagtgcta tccattcctc tcctgagatt ttaacttact     2760



actggaaatc cttaaccaat tataatagct ttttttcttt attttcaaaa tgatttcctt     2820



tgctttgatt agacactatg tgcttttttt ttttaaccat agttcatcga aatgcagctt     2880



tttctgaact tcaaagatag aatcccattt ttaatgaact gaagtagcaa aatcatcttt     2940



ttcattcttt aggaaatagc tattgccaaa gtgaaggtgt agataatacc tagtcttgtt     3000



acataaaggg gatgtggttt gcagaagaat tttctttata aaattgaagt tttaagggac     3060



gtcagtgttt atgccatttt tccagttcca aaatgattcc attccattct agaaatttga     3120



agtatgtaac ctgaaatcct taataaaatt tggatttaat tttataaaat gtactggtga     3180



tattttgggt gttttttttt aaatgaatgt atatactttt tttttgaaga gtggagagta     3240



gtgatgtcta gagggagcta ttttgtgctg aggccactat gttctgtaaa tatataattt     3300



taagagcaac ctcacaatcc ctgctaagtg gagtttatta tttgaagact aaaatggaat     3360



tccatagttc ctgataggtt atattctggg ttattattct gagttatcta caaacatttt     3420



tgagatttgt ctttacactc tgattgtagt ttccagcagc ccatgcacac tgccaagtaa     3480



gtctcatttt ttcctgttag aaatggtgaa atatcatata atcacttata aagaaaactg     3540



atatgaaaaa attttagagt tgtttgcttt atggtcactc aagtagggta agtgttccac     3600



aaattccaca agttgatagt ttaacatgga tgtctgaaag ccacatatat aatttcttag     3660



gattcttaaa ttagtaaatc tagcttactg aagcagtatt agcatcacta ttttagattg     3720



caaaaatacc ttaattgtgt ggaactggct tgtagagtgg tacttaagaa aaatgggatt     3780



ctacctctat ttctgtttta gcacacttaa tcaggaaagg atatattaac tttcataaaa     3840



atatttttgt tgtgtgaata ggttaatgat atggtaaggc ccctaaaata actgaattaa     3900



ttgtttattg taattgtagg ccattcccat tattaaaaat aaagacaaaa cttgaagtaa     3960



ctgaaaatct tatcgtgcta tgtagaaata ttgaactaat attcaaatat ttgaatgctt     4020



tggtttcagg gattggttta aaattggagt ccttttttat gggttagtct tacaaaaatt     4080



taagccttta tatttttgac tttaaatcaa aacaaatgtt attttaaatg tacagaatag     4140



attggtagtg cagaagagtg taagttcttc ataggagctt tagaaaagag aaatatgtgc     4200



taattcagtt tttttttaat ctgcactgta catatatact tggtaattat gagcttgatt     4260



ttgtttttgg aaatatgtgt tcataattta ggtaatttgc tacttaaagc actaagtctc     4320



tgatacctga aaagtacatg taaatggtga tggtgaaata atactgcagt taacttaata     4380



gatgtatact ggtgattttt gtatgctgga ttaaaactcc agatattaaa atataacctg     4440



gataaaaagc c                                                          4451





<210>  165

<211>  391

<212>  PRT

<213>  Homo sapiens



<400>  165



Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 

1               5                   10                  15      





Asp Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 

            20                  25                  30          





Leu Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 

        35                  40                  45              





Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Glu Thr Pro Thr 

    50                  55                  60                  





Gly Tyr Ile Glu Ser Leu Pro Arg Val Val Lys Arg Arg Val Asn Ala 

65                  70                  75                  80  





Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 

                85                  90                  95      





Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 

            100                 105                 110         





Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 

        115                 120                 125             





Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser Glu 

    130                 135                 140                 





Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 

145                 150                 155                 160 





Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 

                165                 170                 175     





Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile 

            180                 185                 190         





Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln 

        195                 200                 205             





Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe 

    210                 215                 220                 





Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp 

225                 230                 235                 240 





Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr 

                245                 250                 255     





Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr 

            260                 265                 270         





Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val 

        275                 280                 285             





Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro Pro 

    290                 295                 300                 





Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile Leu 

305                 310                 315                 320 





Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro 

                325                 330                 335     





Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp 

            340                 345                 350         





Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu 

        355                 360                 365             





Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn 

    370                 375                 380                 





Pro Ala Glu Cys Lys Gln Gln 

385                 390     





<210>  166

<211>  7940

<212>  DNA

<213>  Homo sapiens



<400>  166

tcaagatggc ggccaaggtg gcgaagcagc agccgcggcg gcggcggcgg ctggagtgag       60



cgtccgactc gccgcgccga acgaggtccc ggtgtagggc cgcgcgccgt ggccgcgtcc      120



cactcctcag gccggggcgc acgtcggctc ccacgcttag ccagctcccg gtggtttcct      180



agaaacatga ttgtttattg gcattgatct cacagtctgg tgaggacttc tttactgata      240



atgtcaagtt caggttatcc tcccaaccaa ggagcattca gcacagaaca aagtcgttat      300



cctcctcact ctgtccagta tacatttccc aacacccgcc accagcagga gttcgcagtc      360



cctgattatc gttcctctca tcttgaagtg agtcaggcat cacagctttt gcagcaacag      420



cagcagcaac agcttcgaag gcgaccttcc ttgctttcag aatttcaccc aggttctgac      480



aggcctcaag aaaggagaac tagttatgaa ccgtttcatc caggcccatc cccagtggat      540



catgattcac tggaatcgaa gcgaccacgt ctggaacagg tttctgattc tcattttcag      600



cgtgtcagtg ctgcggtttt gcctttagtg cacccgctgc cagaagggct gagggcttct      660



gcagatgcta agaaggatcc agcattcgga ggcaaacatg aagctccatc ctctccaatt      720



tcggggcaac catgtggaga tgatcaaaat gcttcacctt caaaactctc aaaggaagag      780



ttaatacaga gtatggatcg tgtagatcga gaaattgcaa aagtagaaca gcagatcctt      840



aaactgaaaa agaaacaaca acagcttgaa gaagaggcag ctaaacctcc tgagcctgag      900



aagcccgtgt cccctcctcc tgtggagcag aaacaccgca gtattgtcca aattatttat      960



gatgagaatc ggaaaaaagc agaagaagct cataaaattt ttgaaggtct tggcccaaaa     1020



gttgaactgc cactgtataa ccagccatca gataccaagg tgtaccatga gaacatcaag     1080



acaaaccagg tgatgaggaa aaaactcatt ttatttttta aaagaagaaa tcatgcaaga     1140



aaacaaaggg aacaaaaaat ctgccagcgt tatgatcagc tcatggaggc atgggagaaa     1200



aaagtggaca gaatagaaaa taatcctcgg aggaaagcta aagaaagcaa aacaagggaa     1260



tactatgaaa agcagtttcc agaaattcga aaacaaagag aacagcaaga aagatttcag     1320



cgagttgggc agaggggagc tggtctttca gccaccattg ctaggagtga gcatgagatt     1380



tctgaaatta ttgatgggct ctctgagcag gagaataatg agaaacaaat gcggcagctc     1440



tctgtgattc cacctatgat gtttgatgca gaacaaagac gagtcaagtt cattaacatg     1500



aatgggctta tggaggaccc tatgaaagtg tataaagata ggcagtttat gaatgtttgg     1560



actgaccatg aaaaggagat ctttaaggac aagtttatcc agcatccaaa aaactttgga     1620



ctaattgcat catacttgga gaggaagagt gttcctgatt gtgttttgta ttactattta     1680



accaagaaaa atgagaatta taaagccctc gtcagaagga attatgggaa acgcagaggc     1740



agaaaccagc aaattgctcg accctcgcaa gaagaaaaag tagaagaaaa agaagaggat     1800



aaagcagaaa aaacagaaaa aaaagaagaa gaaaagaaag atgaagagga aaaagatgaa     1860



aaagaagact ccaaagaaaa taccaaggaa aaggacaaga tagatggtac agcagaagaa     1920



actgaggaaa gagagcaagc cacaccccgg gggcgaaaga ctgccaacag tcagggccgc     1980



cgtaagggcc ggatcaccag gtccatgaca aacgaagctg cagctgccag tgctgcagcc     2040



gcagcggcta ctgaagagcc cccaccacct ctgccaccgc caccagaacc catttctaca     2100



gagcctgtgg agacctctcg atggacagaa gaagaaatgg aagttgctaa aaaaggtcta     2160



gtagaacatg gtcgtaactg ggcagcaatt gctaaaatgg tgggaacgaa aagtgaagct     2220



caatgtaaaa acttctattt taactataaa aggcgacaca atcttgacaa cctcttacag     2280



cagcataaac agaaaacttc acgaaaacct cgtgaagagc gagatgtgtc tcaatgtgaa     2340



agtgtcgctt ccactgtttc tgctcaggag gatgaagata ttgaagcctc caatgaagaa     2400



gaaaatccag aagacagcga agttgaagct gtcaagccca gcgaggacag tcctgaaaat     2460



gctacttctc gaggaaacac agaacctgcg gttgagcttg agcccaccac ggaaactgca     2520



cccagtacat ctccctcctt agcagttcca agtacaaaac cagctgaaga tgaaagtgtg     2580



gagacccagg tgaatgacag catcagtgct gagacagcag agcagatgga tgtagatcag     2640



caggagcaca gtgctgaaga gggttctgtt tgtgatcccc cacccgctac caaagctgac     2700



tctgtggacg ttgaagtgag ggtgccagaa aaccatgcat ctaaagttga aggtgataat     2760



accaaagaaa gagacttgga tagagccagt gagaaggtgg aacctagaga tgaagatttg     2820



gtggtagctc agcaaataaa tgcccaaagg cccgagcccc agtcagacaa tgattccagt     2880



gccacgtgca gcgctgatga ggatgtggat ggagagccag agaggcagag aatgtttcct     2940



atggactcaa agccttcact gttaaacccc actggatcta tactcgtctc atctccgtta     3000



aaaccaaatc cactggatct gccacagctt cagcatcgag ctgctgttat cccaccaatg     3060



gtatcctgca ccccatgtaa cataccaatt ggaaccccag tgagcggcta tgctctctac     3120



cagcgacaca ttaaagcaat gcatgagtca gcactcctgg aggagcagcg gcagagacaa     3180



gaacagatag atttggaatg tagaagttct acaagtccat gtggcacatc caagagtcca     3240



aacagagagt gggaagtcct tcagcctgct ccacatcaag tgataactaa tctccctgaa     3300



ggcgttcggc ttccgacaac tcgaccaacc aggccaccgc cccctctcat cccgtcatcc     3360



aaaaccacag tggcttcaga aaaaccatct tttataatgg gaggctccat ctcacaggga     3420



acaccaggca cttatttgac ttctcataat caggcttcct acactcaaga aacacccaag     3480



ccgtcagtgg gatctatctc tcttggactg ccacggcaac aggaatctgc caaatcagct     3540



actttgccct acatcaagca ggaagaattt tctccccgaa gccaaaactc acaacctgag     3600



ggtctgttgg tcagggccca acatgaaggt gtagtcagag gtaccgcagg agccatacaa     3660



gaaggaagta taactcgggg aactccaacc agcaaaattt cagtggagag cattccatcc     3720



ctacggggct ctatcactca gggcaccccg gctctgcccc agactggcat accaacagag     3780



gctttggtga aggggtccat ttcgagaatg cccattgaag acagcagtcc tgagaaaggc     3840



agagaggaag ctgcatccaa aggccatgtt atttatgaag gcaaaagtgg acatatcttg     3900



tcatatgata atattaagaa tgcccgagaa gggactagga gtccaagaac agctcatgaa     3960



atcagtttaa agagaagcta tgaatcagtg gaaggaaata taaagcaagg gatgtcaatg     4020



agggagtctc ctgtatcagc accgttagag gggctgatat gccgagcatt acccaggggg     4080



agtcctcatt ctgacctcaa agaaaggact gtattgtctg gctccataat gcaggggaca     4140



ccaagagcaa caactgaaag ctttgaagat ggccttaaat atcccaaaca aattaaaagg     4200



gaaagtcctc ccatacgagc atttgaaggt gccattacca aaggaaaacc atatgatggc     4260



atcaccacca tcaaagaaat ggggcgttcc attcatgaga ttccaaggca agatatttta     4320



actcaggaaa gtcggaaaac tccagaagtg gtccagagca cacggccgat aattgagggt     4380



tccatttccc agggcacacc aataaagttt gacaacaact caggtcaatc tgccatcaaa     4440



cacaatgtca aatccttaat cacggggcct agcaaactat cccgtggaat gcctccgctg     4500



gaaattgtgc cagagaacat aaaagtggta gaacggggaa aatatgagga tgtgaaagca     4560



ggcgagaccg tgcgttcccg gcacacgtca gtggtaagct ctggcccctc cgttcttagg     4620



tccacactgc atgaagctcc caaagcacaa ctgagccctg ggatttatga tgacaccagt     4680



gcacggagga cccctgtgag ttatcaaaac accatgtcca gaggctcacc catgatgaac     4740



agaacttctg atgttacaat ttcttctaac aagtctacca atcatgaaag gaaatcgaca     4800



ctgaccccta cccagaggga aagtatccca gcgaagtctc cagtgcctgg ggtggaccct     4860



gtcgtgagcc acagtccgtt tgatccccat cacagaggca gcactgcagg cgaggtttat     4920



cggagccacc tgcccacgca cttggatcca gccatgcctt ttcacagggc tttggatcct     4980



gcagcggctg cttacctgtt tcagagacag ctttcaccaa ctccaggtta cccaagtcag     5040



tatcagcttt acgcaatgga gaacacaaga cagacaatct taaatgatta cattacctca     5100



caacagatgc aagtgaactt gcgtccagat gtggccagag gactctcccc aagagagcag     5160



ccactgggtc tcccataccc agcaacgaga ggaatcattg acctgaccaa tatgcctcca     5220



acaattttag tgcctcatcc agggggaaca agcactcctc ccatggacag aatcacttat     5280



attcctggta cacagattac tttccctccc aggccgtaca actctgcttc catgtctcca     5340



ggacacccaa cacaccttgc agctgctgca agtgctgaga gggaacggga acgggagcgg     5400



gagaaggagc gggagcggga acggattgct gcagcttcct ccgacctcta cctgcggcca     5460



ggctcagaac agcctggccg acctggcagt catggatatg ttcgctcccc ttccccttca     5520



gtaagaactc aggagaccat gttgcaacag agacccagtg ttttccaagg aaccaatgga     5580



accagtgtaa tcacaccttt ggatccaact gctcagctac gaatcatgcc actgcctgct     5640



gggggccctt caataagcca aggcctgcca gcctcccgtt acaacactgc tgcggatgcc     5700



ctggctgctc ttgtggatgc tgcagcttct gcaccccaga tggatgtgtc caaaacaaaa     5760



gagagtaagc atgaagctgc caggttagaa gaaaatttga gaagcaggtc agcagcagtt     5820



agtgaacagc agcagctaga gcagaaaacc ctggaggtgg agaagagatc tgttcagtgt     5880



ttatacactt cttcagcctt tccaagtggc aagccccagc ctcattcttc agtagtttat     5940



tctgaggctg ggaaagataa agggcctcct ccaaaatcca gatatgagga agagctaagg     6000



accagaggga agactaccat tactgcagct aacttcatag acgtgatcat cacccggcaa     6060



attgcctcgg acaaggatgc gagggaacgt ggctctcaaa gttcagactc ttctagtagc     6120



ttatcttctc acaggtatga aacacctagc gatgctattg aggtgataag tcctgccagc     6180



tcacctgcgc caccccagga gaaactgcag acctatcagc cagaggttgt taaggcaaat     6240



caagcggaaa atgatcctac cagacaatat gaaggaccat tacatcacta tcgaccacag     6300



caggaatcac catctcccca acaacagctg cccccttctt cacaggcaga gggaatgggg     6360



caagtgccca ggacccatcg gctgatcaca cttgctgatc acatctgtca aattatcaca     6420



caagattttg ctagaaatca agtttcctcg cagactcccc agcagcctcc tacttctaca     6480



ttccagaact caccttctgc tttggtatct acacctgtga ggactaaaac atcaaaccgt     6540



tacagcccag aatcccaggc tcagtctgtc catcatcaaa gaccaggttc aagggtctct     6600



ccagaaaatc ttgtggacaa atccagggga agtaggcctg gaaaatcccc agagaggagt     6660



cacgtctctt cggagcccta cgagcccatc tccccacccc aggttccggt tgtgcatgag     6720



aaacaggaca gcttgctgct cttgtctcag aggggcgcag agcctgcaga gcagaggaat     6780



gatgcccgct caccagggag tataagctac ttgccttcat tcttcaccaa gcttgaaaat     6840



acatcaccca tggttaaatc aaagaagcag gagatttttc gtaagttgaa ctcctctggt     6900



ggaggtgact ctgatatggc agctgctcag ccaggaactg agatctttaa tctgccagca     6960



gttactacgt caggctcagt tagctctaga ggccattctt ttgctgatcc tgccagtaat     7020



cttgggctgg aagacattat caggaaggct ctcatgggaa gctttgatga caaagttgag     7080



gatcatggag ttgtcatgtc ccagcctatg ggagtagtgc ctggtactgc caacacctca     7140



gttgtgacca gtggtgagac acgaagagag gaaggggacc catcacctca ttcaggagga     7200



gtttgcaaac caaagctgat cagcaagtca aacagcagga aatctaagtc tcctatacct     7260



gggcaaggct acttaggaac ggaacggccc tcttcagtct cctctgtaca ttcagaaggg     7320



gattaccata ggcagacgcc agggtgggcc tgggaagaca ggccctcttc aacaggctca     7380



actcagtttc cttataaccc tctgactatg cggatgctca gcagtactcc accaacaccg     7440



attgcatgtg ctccctctgc ggtgaaccaa gcagctcctc accaacagaa caggatctgg     7500



gagcgagagc ctgccccact gctctcagca cagtacgaga ccctgtcgga tagtgatgac     7560



tgaactgcac aaagtgaggg gaacagggtg caggagaggg atctctagtt tttgtggttt     7620



aatttttagt agcaggtcaa aaacctgccc tcctgtgact tattccctga gacttttcag     7680



gagagccagc ccacagatga tgaagaaatg atggaagttc atttggagag tcaaatggga     7740



aaaaaacaaa caaaaaactg cctttgatac aggcaattca gtggactata ataatagtgg     7800



agggttgaga tgtagagttt ttaaaaagtg aacagttgct gttcttacat ctgtaaagaa     7860



aaccataatg tctttaaatc actcttctgt aaatagatga cctttttgca gtgtaaaaaa     7920



aaaaaaaaaa aaaaaaaaaa                                                 7940





<210>  167

<211>  2440

<212>  PRT

<213>  Homo sapiens



<400>  167



Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 

1               5                   10                  15      





Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 

            20                  25                  30          





Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 

        35                  40                  45              





Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 

    50                  55                  60                  





Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 

65                  70                  75                  80  





Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 

                85                  90                  95      





Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 

            100                 105                 110         





Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 

        115                 120                 125             





Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 

    130                 135                 140                 





Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 

145                 150                 155                 160 





Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 

                165                 170                 175     





Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 

            180                 185                 190         





Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 

        195                 200                 205             





Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 

    210                 215                 220                 





Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 

225                 230                 235                 240 





Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 

                245                 250                 255     





Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 

            260                 265                 270         





Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met Arg Lys Lys 

        275                 280                 285             





Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys Gln Arg Glu 

    290                 295                 300                 





Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala Trp Glu Lys 

305                 310                 315                 320 





Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala Lys Glu Ser 

                325                 330                 335     





Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile Arg Lys Gln 

            340                 345                 350         





Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg Gly Ala Gly 

        355                 360                 365             





Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser Glu Ile Ile 

    370                 375                 380                 





Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met Arg Gln Leu 

385                 390                 395                 400 





Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg Arg Val Lys 

                405                 410                 415     





Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys Val Tyr Lys 

            420                 425                 430         





Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys Glu Ile Phe 

        435                 440                 445             





Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu Ile Ala Ser 

    450                 455                 460                 





Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr Tyr Tyr Leu 

465                 470                 475                 480 





Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg Asn Tyr Gly 

                485                 490                 495     





Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser Gln Glu Glu 

            500                 505                 510         





Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr Glu Lys Lys 

        515                 520                 525             





Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys Glu Asp Ser 

    530                 535                 540                 





Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr Ala Glu Glu 

545                 550                 555                 560 





Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys Thr Ala Asn 

                565                 570                 575     





Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met Thr Asn Glu 

            580                 585                 590         





Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu Glu Pro Pro 

        595                 600                 605             





Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu Pro Val Glu 

    610                 615                 620                 





Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys Lys Gly Leu 

625                 630                 635                 640 





Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met Val Gly Thr 

                645                 650                 655     





Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr Lys Arg Arg 

            660                 665                 670         





His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys Thr Ser Arg 

        675                 680                 685             





Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser Val Ala Ser 

    690                 695                 700                 





Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser Asn Glu Glu 

705                 710                 715                 720 





Glu Asn Pro Glu Asp Ser Glu Val Glu Ala Val Lys Pro Ser Glu Asp 

                725                 730                 735     





Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro Ala Val Glu 

            740                 745                 750         





Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro Ser Leu Ala 

        755                 760                 765             





Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu Thr Gln Val 

    770                 775                 780                 





Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp Val Asp Gln 

785                 790                 795                 800 





Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro Pro Pro Ala 

                805                 810                 815     





Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro Glu Asn His 

            820                 825                 830         





Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp Leu Asp Arg 

        835                 840                 845             





Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val Val Ala Gln 

    850                 855                 860                 





Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn Asp Ser Ser 

865                 870                 875                 880 





Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro Glu Arg Gln 

                885                 890                 895     





Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn Pro Thr Gly 

            900                 905                 910         





Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu Asp Leu Pro 

        915                 920                 925             





Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val Ser Cys Thr 

    930                 935                 940                 





Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr Ala Leu Tyr 

945                 950                 955                 960 





Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu Glu Glu Gln 

                965                 970                 975     





Arg Gln Arg Gln Glu Gln Ile Asp Leu Glu Cys Arg Ser Ser Thr Ser 

            980                 985                 990         





Pro Cys Gly Thr Ser Lys Ser Pro  Asn Arg Glu Trp Glu  Val Leu Gln 

        995                 1000                 1005             





Pro Ala  Pro His Gln Val Ile  Thr Asn Leu Pro Glu  Gly Val Arg 

    1010                 1015                 1020             





Leu Pro  Thr Thr Arg Pro Thr  Arg Pro Pro Pro Pro  Leu Ile Pro 

    1025                 1030                 1035             





Ser Ser  Lys Thr Thr Val Ala  Ser Glu Lys Pro Ser  Phe Ile Met 

    1040                 1045                 1050             





Gly Gly  Ser Ile Ser Gln Gly  Thr Pro Gly Thr Tyr  Leu Thr Ser 

    1055                 1060                 1065             





His Asn  Gln Ala Ser Tyr Thr  Gln Glu Thr Pro Lys  Pro Ser Val 

    1070                 1075                 1080             





Gly Ser  Ile Ser Leu Gly Leu  Pro Arg Gln Gln Glu  Ser Ala Lys 

    1085                 1090                 1095             





Ser Ala  Thr Leu Pro Tyr Ile  Lys Gln Glu Glu Phe  Ser Pro Arg 

    1100                 1105                 1110             





Ser Gln  Asn Ser Gln Pro Glu  Gly Leu Leu Val Arg  Ala Gln His 

    1115                 1120                 1125             





Glu Gly  Val Val Arg Gly Thr  Ala Gly Ala Ile Gln  Glu Gly Ser 

    1130                 1135                 1140             





Ile Thr  Arg Gly Thr Pro Thr  Ser Lys Ile Ser Val  Glu Ser Ile 

    1145                 1150                 1155             





Pro Ser  Leu Arg Gly Ser Ile  Thr Gln Gly Thr Pro  Ala Leu Pro 

    1160                 1165                 1170             





Gln Thr  Gly Ile Pro Thr Glu  Ala Leu Val Lys Gly  Ser Ile Ser 

    1175                 1180                 1185             





Arg Met  Pro Ile Glu Asp Ser  Ser Pro Glu Lys Gly  Arg Glu Glu 

    1190                 1195                 1200             





Ala Ala  Ser Lys Gly His Val  Ile Tyr Glu Gly Lys  Ser Gly His 

    1205                 1210                 1215             





Ile Leu  Ser Tyr Asp Asn Ile  Lys Asn Ala Arg Glu  Gly Thr Arg 

    1220                 1225                 1230             





Ser Pro  Arg Thr Ala His Glu  Ile Ser Leu Lys Arg  Ser Tyr Glu 

    1235                 1240                 1245             





Ser Val  Glu Gly Asn Ile Lys  Gln Gly Met Ser Met  Arg Glu Ser 

    1250                 1255                 1260             





Pro Val  Ser Ala Pro Leu Glu  Gly Leu Ile Cys Arg  Ala Leu Pro 

    1265                 1270                 1275             





Arg Gly  Ser Pro His Ser Asp  Leu Lys Glu Arg Thr  Val Leu Ser 

    1280                 1285                 1290             





Gly Ser  Ile Met Gln Gly Thr  Pro Arg Ala Thr Thr  Glu Ser Phe 

    1295                 1300                 1305             





Glu Asp  Gly Leu Lys Tyr Pro  Lys Gln Ile Lys Arg  Glu Ser Pro 

    1310                 1315                 1320             





Pro Ile  Arg Ala Phe Glu Gly  Ala Ile Thr Lys Gly  Lys Pro Tyr 

    1325                 1330                 1335             





Asp Gly  Ile Thr Thr Ile Lys  Glu Met Gly Arg Ser  Ile His Glu 

    1340                 1345                 1350             





Ile Pro  Arg Gln Asp Ile Leu  Thr Gln Glu Ser Arg  Lys Thr Pro 

    1355                 1360                 1365             





Glu Val  Val Gln Ser Thr Arg  Pro Ile Ile Glu Gly  Ser Ile Ser 

    1370                 1375                 1380             





Gln Gly  Thr Pro Ile Lys Phe  Asp Asn Asn Ser Gly  Gln Ser Ala 

    1385                 1390                 1395             





Ile Lys  His Asn Val Lys Ser  Leu Ile Thr Gly Pro  Ser Lys Leu 

    1400                 1405                 1410             





Ser Arg  Gly Met Pro Pro Leu  Glu Ile Val Pro Glu  Asn Ile Lys 

    1415                 1420                 1425             





Val Val  Glu Arg Gly Lys Tyr  Glu Asp Val Lys Ala  Gly Glu Thr 

    1430                 1435                 1440             





Val Arg  Ser Arg His Thr Ser  Val Val Ser Ser Gly  Pro Ser Val 

    1445                 1450                 1455             





Leu Arg  Ser Thr Leu His Glu  Ala Pro Lys Ala Gln  Leu Ser Pro 

    1460                 1465                 1470             





Gly Ile  Tyr Asp Asp Thr Ser  Ala Arg Arg Thr Pro  Val Ser Tyr 

    1475                 1480                 1485             





Gln Asn  Thr Met Ser Arg Gly  Ser Pro Met Met Asn  Arg Thr Ser 

    1490                 1495                 1500             





Asp Val  Thr Ile Ser Ser Asn  Lys Ser Thr Asn His  Glu Arg Lys 

    1505                 1510                 1515             





Ser Thr  Leu Thr Pro Thr Gln  Arg Glu Ser Ile Pro  Ala Lys Ser 

    1520                 1525                 1530             





Pro Val  Pro Gly Val Asp Pro  Val Val Ser His Ser  Pro Phe Asp 

    1535                 1540                 1545             





Pro His  His Arg Gly Ser Thr  Ala Gly Glu Val Tyr  Arg Ser His 

    1550                 1555                 1560             





Leu Pro  Thr His Leu Asp Pro  Ala Met Pro Phe His  Arg Ala Leu 

    1565                 1570                 1575             





Asp Pro  Ala Ala Ala Ala Tyr  Leu Phe Gln Arg Gln  Leu Ser Pro 

    1580                 1585                 1590             





Thr Pro  Gly Tyr Pro Ser Gln  Tyr Gln Leu Tyr Ala  Met Glu Asn 

    1595                 1600                 1605             





Thr Arg  Gln Thr Ile Leu Asn  Asp Tyr Ile Thr Ser  Gln Gln Met 

    1610                 1615                 1620             





Gln Val  Asn Leu Arg Pro Asp  Val Ala Arg Gly Leu  Ser Pro Arg 

    1625                 1630                 1635             





Glu Gln  Pro Leu Gly Leu Pro  Tyr Pro Ala Thr Arg  Gly Ile Ile 

    1640                 1645                 1650             





Asp Leu  Thr Asn Met Pro Pro  Thr Ile Leu Val Pro  His Pro Gly 

    1655                 1660                 1665             





Gly Thr  Ser Thr Pro Pro Met  Asp Arg Ile Thr Tyr  Ile Pro Gly 

    1670                 1675                 1680             





Thr Gln  Ile Thr Phe Pro Pro  Arg Pro Tyr Asn Ser  Ala Ser Met 

    1685                 1690                 1695             





Ser Pro  Gly His Pro Thr His  Leu Ala Ala Ala Ala  Ser Ala Glu 

    1700                 1705                 1710             





Arg Glu  Arg Glu Arg Glu Arg  Glu Lys Glu Arg Glu  Arg Glu Arg 

    1715                 1720                 1725             





Ile Ala  Ala Ala Ser Ser Asp  Leu Tyr Leu Arg Pro  Gly Ser Glu 

    1730                 1735                 1740             





Gln Pro  Gly Arg Pro Gly Ser  His Gly Tyr Val Arg  Ser Pro Ser 

    1745                 1750                 1755             





Pro Ser  Val Arg Thr Gln Glu  Thr Met Leu Gln Gln  Arg Pro Ser 

    1760                 1765                 1770             





Val Phe  Gln Gly Thr Asn Gly  Thr Ser Val Ile Thr  Pro Leu Asp 

    1775                 1780                 1785             





Pro Thr  Ala Gln Leu Arg Ile  Met Pro Leu Pro Ala  Gly Gly Pro 

    1790                 1795                 1800             





Ser Ile  Ser Gln Gly Leu Pro  Ala Ser Arg Tyr Asn  Thr Ala Ala 

    1805                 1810                 1815             





Asp Ala  Leu Ala Ala Leu Val  Asp Ala Ala Ala Ser  Ala Pro Gln 

    1820                 1825                 1830             





Met Asp  Val Ser Lys Thr Lys  Glu Ser Lys His Glu  Ala Ala Arg 

    1835                 1840                 1845             





Leu Glu  Glu Asn Leu Arg Ser  Arg Ser Ala Ala Val  Ser Glu Gln 

    1850                 1855                 1860             





Gln Gln  Leu Glu Gln Lys Thr  Leu Glu Val Glu Lys  Arg Ser Val 

    1865                 1870                 1875             





Gln Cys  Leu Tyr Thr Ser Ser  Ala Phe Pro Ser Gly  Lys Pro Gln 

    1880                 1885                 1890             





Pro His  Ser Ser Val Val Tyr  Ser Glu Ala Gly Lys  Asp Lys Gly 

    1895                 1900                 1905             





Pro Pro  Pro Lys Ser Arg Tyr  Glu Glu Glu Leu Arg  Thr Arg Gly 

    1910                 1915                 1920             





Lys Thr  Thr Ile Thr Ala Ala  Asn Phe Ile Asp Val  Ile Ile Thr 

    1925                 1930                 1935             





Arg Gln  Ile Ala Ser Asp Lys  Asp Ala Arg Glu Arg  Gly Ser Gln 

    1940                 1945                 1950             





Ser Ser  Asp Ser Ser Ser Ser  Leu Ser Ser His Arg  Tyr Glu Thr 

    1955                 1960                 1965             





Pro Ser  Asp Ala Ile Glu Val  Ile Ser Pro Ala Ser  Ser Pro Ala 

    1970                 1975                 1980             





Pro Pro  Gln Glu Lys Leu Gln  Thr Tyr Gln Pro Glu  Val Val Lys 

    1985                 1990                 1995             





Ala Asn  Gln Ala Glu Asn Asp  Pro Thr Arg Gln Tyr  Glu Gly Pro 

    2000                 2005                 2010             





Leu His  His Tyr Arg Pro Gln  Gln Glu Ser Pro Ser  Pro Gln Gln 

    2015                 2020                 2025             





Gln Leu  Pro Pro Ser Ser Gln  Ala Glu Gly Met Gly  Gln Val Pro 

    2030                 2035                 2040             





Arg Thr  His Arg Leu Ile Thr  Leu Ala Asp His Ile  Cys Gln Ile 

    2045                 2050                 2055             





Ile Thr  Gln Asp Phe Ala Arg  Asn Gln Val Ser Ser  Gln Thr Pro 

    2060                 2065                 2070             





Gln Gln  Pro Pro Thr Ser Thr  Phe Gln Asn Ser Pro  Ser Ala Leu 

    2075                 2080                 2085             





Val Ser  Thr Pro Val Arg Thr  Lys Thr Ser Asn Arg  Tyr Ser Pro 

    2090                 2095                 2100             





Glu Ser  Gln Ala Gln Ser Val  His His Gln Arg Pro  Gly Ser Arg 

    2105                 2110                 2115             





Val Ser  Pro Glu Asn Leu Val  Asp Lys Ser Arg Gly  Ser Arg Pro 

    2120                 2125                 2130             





Gly Lys  Ser Pro Glu Arg Ser  His Val Ser Ser Glu  Pro Tyr Glu 

    2135                 2140                 2145             





Pro Ile  Ser Pro Pro Gln Val  Pro Val Val His Glu  Lys Gln Asp 

    2150                 2155                 2160             





Ser Leu  Leu Leu Leu Ser Gln  Arg Gly Ala Glu Pro  Ala Glu Gln 

    2165                 2170                 2175             





Arg Asn  Asp Ala Arg Ser Pro  Gly Ser Ile Ser Tyr  Leu Pro Ser 

    2180                 2185                 2190             





Phe Phe  Thr Lys Leu Glu Asn  Thr Ser Pro Met Val  Lys Ser Lys 

    2195                 2200                 2205             





Lys Gln  Glu Ile Phe Arg Lys  Leu Asn Ser Ser Gly  Gly Gly Asp 

    2210                 2215                 2220             





Ser Asp  Met Ala Ala Ala Gln  Pro Gly Thr Glu Ile  Phe Asn Leu 

    2225                 2230                 2235             





Pro Ala  Val Thr Thr Ser Gly  Ser Val Ser Ser Arg  Gly His Ser 

    2240                 2245                 2250             





Phe Ala  Asp Pro Ala Ser Asn  Leu Gly Leu Glu Asp  Ile Ile Arg 

    2255                 2260                 2265             





Lys Ala  Leu Met Gly Ser Phe  Asp Asp Lys Val Glu  Asp His Gly 

    2270                 2275                 2280             





Val Val  Met Ser Gln Pro Met  Gly Val Val Pro Gly  Thr Ala Asn 

    2285                 2290                 2295             





Thr Ser  Val Val Thr Ser Gly  Glu Thr Arg Arg Glu  Glu Gly Asp 

    2300                 2305                 2310             





Pro Ser  Pro His Ser Gly Gly  Val Cys Lys Pro Lys  Leu Ile Ser 

    2315                 2320                 2325             





Lys Ser  Asn Ser Arg Lys Ser  Lys Ser Pro Ile Pro  Gly Gln Gly 

    2330                 2335                 2340             





Tyr Leu  Gly Thr Glu Arg Pro  Ser Ser Val Ser Ser  Val His Ser 

    2345                 2350                 2355             





Glu Gly  Asp Tyr His Arg Gln  Thr Pro Gly Trp Ala  Trp Glu Asp 

    2360                 2365                 2370             





Arg Pro  Ser Ser Thr Gly Ser  Thr Gln Phe Pro Tyr  Asn Pro Leu 

    2375                 2380                 2385             





Thr Met  Arg Met Leu Ser Ser  Thr Pro Pro Thr Pro  Ile Ala Cys 

    2390                 2395                 2400             





Ala Pro  Ser Ala Val Asn Gln  Ala Ala Pro His Gln  Gln Asn Arg 

    2405                 2410                 2415             





Ile Trp  Glu Arg Glu Pro Ala  Pro Leu Leu Ser Ala  Gln Tyr Glu 

    2420                 2425                 2430             





Thr Leu  Ser Asp Ser Asp Asp  

    2435                 2440 





<210>  168

<211>  2185

<212>  DNA

<213>  Homo sapiens



<400>  168

aatgactcag taagttcagc gcgcccgctc cggccggccc tgcgcctccc gccgcgcccg       60



ggatgtattc gtccccgctc tgcctcaccc aggatgagtt ccacccgttc atcgaggccc      120



tgctgcctca cgtccgcgcc ttcgcctaca cctggttcaa cctgcaggcg cggaagcgca      180



agtacttcaa gaagcacgag aagcggatgt cgaaggacga ggagcgtgcg gtcaaggacg      240



agctgctggg cgagaagccc gaggtcaagc agaagtgggc gtcgcggctg ctggccaagc      300



tgcgcaagga catccggccc gagtgccgcg aggacttcgt gctgagcatc accggcaaga      360



aggcgccggg ctgcgtgctc tccaaccccg accagaaggg caagatgcgg cgcatcgact      420



gtctccggca ggcggacaag gtgtggcggc tggacctggt catggtcatc ctgttcaagg      480



gcatcccgct ggagagcacc gacggcgagc gcctggtcaa ggctgcgcag tgcggtcacc      540



cggtcctgtg cgtgcagccg caccacattg gcgtggccgt caaggagctg gacctctacc      600



tggcctactt cgtgcgtgag cgagatgcag agcaaagcgg cagtccccgg acagggatgg      660



gctctgacca ggaggacagc aagcccatca cgctggacac gaccgacttc caggagagct      720



ttgtcacctc cggcgtgttc agcgtcactg agctcatcca agtgtcccgg acacccgtgg      780



tgactggaac aggacccaac ttctccctgg gggagctgca ggggcacctg gcatacgacc      840



tgaacccagc cagcactggc ctcagaagaa cgctgcccag cacctcctcc agtgggagca      900



agcggcacaa atcgggctcg atggaggaag acgtggacac gagccctggc ggcgattact      960



acacttcgcc cagctcgccc acgagtagca gccgcaactg gacggaggac atggaaggag     1020



gcatctcgtc cccggtgaag aagacagaga tggacaagtc accattcaac agcccgtccc     1080



cccaggactc tccccgcctc tccagcttca cccagcacca ccggcccgtc atcgccgtgc     1140



acagcgggat cgcccggagc ccacacccgt cctccgctct gcatttccct acgacgtcca     1200



tcctacccca gacggcctcc acctacttcc cccacacggc catccgctac ccacctcatc     1260



tcaaccccca ggacccgctc aaagatcttg tctcgctggc ctgcgaccca gccagccagc     1320



aacctggacc gtcctggtat ctgggatagc aaaggtcttc ttccctcgcc ccttctccat     1380



cgtcccagga atcccagggg gcagcacagc cggcccccgg cccacgtttt cggtggaaaa     1440



ttagagtgaa caagaacacc cctgccgact cccagcccgg ccaaaaagac aaaacacata     1500



gacgcacaca ctcaggagga aaagaaaaaa caaaggcaga agaagaagaa gaagaaataa     1560



aaacccaccc aagcaagaag acaaaaggta aagacgcaac gtttccaact ctcgggacgc     1620



caaggccgca ggactggagg gccaggcccc gccaccccca cgggagaccc gggacagggc     1680



gtcttcctaa gttattcatc tcctctccgc ctgctgctcg ggaaggacag acgccggccg     1740



cccgcccgcg ccccggaggc cctggctctg tccggagacc aggtgagcac agcctggagc     1800



ctgtgcccag ggccgacagg cgcgacaccc agcaaggcca cctctccccg ggcccccgcg     1860



cctctgccgg acacggaccg gcccctcagc ccccaccgag gacgcagcca ctggggggaa     1920



agggagacac agcggacccc ggccgggcag cggagaccgc agaggcgggc agggtggggc     1980



aggcgagtgg tgtcgcgggg gtgcgtggcg cttgcgagcc ctggccaggg gaggaagtga     2040



ggcccaggca cctgctgccc ctcgaggggg ccctgcctgc cgcggggcct ccccacaagc     2100



ccctcccaaa gcgccggccg actcgctgtc tcgctgggga ctctttcagc cctcgcgccc     2160



gcccgtttgg gaggagaagt ctcta                                           2185





<210>  169

<211>  428

<212>  PRT

<213>  Homo sapiens



<400>  169



Met Tyr Ser Ser Pro Leu Cys Leu Thr Gln Asp Glu Phe His Pro Phe 

1               5                   10                  15      





Ile Glu Ala Leu Leu Pro His Val Arg Ala Phe Ala Tyr Thr Trp Phe 

            20                  25                  30          





Asn Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg 

        35                  40                  45              





Met Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu 

    50                  55                  60                  





Lys Pro Glu Val Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu 

65                  70                  75                  80  





Arg Lys Asp Ile Arg Pro Glu Cys Arg Glu Asp Phe Val Leu Ser Ile 

                85                  90                  95      





Thr Gly Lys Lys Ala Pro Gly Cys Val Leu Ser Asn Pro Asp Gln Lys 

            100                 105                 110         





Gly Lys Met Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp 

        115                 120                 125             





Arg Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu 

    130                 135                 140                 





Ser Thr Asp Gly Glu Arg Leu Val Lys Ala Ala Gln Cys Gly His Pro 

145                 150                 155                 160 





Val Leu Cys Val Gln Pro His His Ile Gly Val Ala Val Lys Glu Leu 

                165                 170                 175     





Asp Leu Tyr Leu Ala Tyr Phe Val Arg Glu Arg Asp Ala Glu Gln Ser 

            180                 185                 190         





Gly Ser Pro Arg Thr Gly Met Gly Ser Asp Gln Glu Asp Ser Lys Pro 

        195                 200                 205             





Ile Thr Leu Asp Thr Thr Asp Phe Gln Glu Ser Phe Val Thr Ser Gly 

    210                 215                 220                 





Val Phe Ser Val Thr Glu Leu Ile Gln Val Ser Arg Thr Pro Val Val 

225                 230                 235                 240 





Thr Gly Thr Gly Pro Asn Phe Ser Leu Gly Glu Leu Gln Gly His Leu 

                245                 250                 255     





Ala Tyr Asp Leu Asn Pro Ala Ser Thr Gly Leu Arg Arg Thr Leu Pro 

            260                 265                 270         





Ser Thr Ser Ser Ser Gly Ser Lys Arg His Lys Ser Gly Ser Met Glu 

        275                 280                 285             





Glu Asp Val Asp Thr Ser Pro Gly Gly Asp Tyr Tyr Thr Ser Pro Ser 

    290                 295                 300                 





Ser Pro Thr Ser Ser Ser Arg Asn Trp Thr Glu Asp Met Glu Gly Gly 

305                 310                 315                 320 





Ile Ser Ser Pro Val Lys Lys Thr Glu Met Asp Lys Ser Pro Phe Asn 

                325                 330                 335     





Ser Pro Ser Pro Gln Asp Ser Pro Arg Leu Ser Ser Phe Thr Gln His 

            340                 345                 350         





His Arg Pro Val Ile Ala Val His Ser Gly Ile Ala Arg Ser Pro His 

        355                 360                 365             





Pro Ser Ser Ala Leu His Phe Pro Thr Thr Ser Ile Leu Pro Gln Thr 

    370                 375                 380                 





Ala Ser Thr Tyr Phe Pro His Thr Ala Ile Arg Tyr Pro Pro His Leu 

385                 390                 395                 400 





Asn Pro Gln Asp Pro Leu Lys Asp Leu Val Ser Leu Ala Cys Asp Pro 

                405                 410                 415     





Ala Ser Gln Gln Pro Gly Pro Ser Trp Tyr Leu Gly 

            420                 425             





<210>  170

<211>  2401

<212>  DNA

<213>  Homo sapiens



<400>  170

ccccccctcg ccggggaccg agcgcgctcg ctccggcgcc ggcctcgcct cctcgcagca       60



gcgccatgga tgagttccac ccgttcatcg aggccctgct gcctcacgtc cgcgccttcg      120



cctacacctg gttcaacctg caggcgcgga agcgcaagta cttcaagaag cacgagaagc      180



ggatgtcgaa ggacgaggag cgtgcggtca aggacgagct gctgggcgag aagcccgagg      240



tcaagcagaa gtgggcgtcg cggctgctgg ccaagctgcg caaggacatc cggcccgagt      300



gccgcgagga cttcgtgctg agcatcaccg gcaagaaggc gccgggctgc gtgctctcca      360



accccgacca gaagggcaag atgcggcgca tcgactgtct ccggcaggcg gacaaggtgt      420



ggcggctgga cctggtcatg gtcatcctgt tcaagggcat cccgctggag agcaccgacg      480



gcgagcgcct ggtcaaggct gcgcagtgcg gtcacccggt cctgtgcgtg cagccgcacc      540



acattggcgt ggccgtcaag gagctggacc tctacctggc ctacttcgtg cgtgagcgag      600



atgcagagca aagcggcagt ccccggacag ggatgggctc tgaccaggag gacagcaagc      660



ccatcacgct ggacacgacc gacttccagg agagctttgt cacctccggc gtgttcagcg      720



tcactgagct catccaagtg tcccggacac ccgtggtgac tggaacagga cccaacttct      780



ccctggggga gctgcagggg cacctggcat acgacctgaa cccagccagc actggcctca      840



gaagaacgct gcccagcacc tcctccagtg ggagcaagcg gcacaaatcg ggctcgatgg      900



aggaagacgt ggacacgagc cctggcggcg attactacac ttcgcccagc tcgcccacga      960



gtagcagccg caactggacg gaggacatgg aaggaggcat ctcgtccccg gtgaagaaga     1020



cagagatgga caagtcacca ttcaacagcc cgtcccccca ggactctccc cgcctctcca     1080



gcttcaccca gcaccaccgg cccgtcatcg ccgtgcacag cgggatcgcc cggagcccac     1140



acccgtcctc cgctctgcat ttccctacga cgtccatcct accccagacg gcctccacct     1200



acttccccca cacggccatc cgctacccac ctcatctcaa cccccaggac ccgctcaaag     1260



atcttgtctc gctggcctgc gacccagcca gccagcaacc tggaccgtta aatggaagtg     1320



gtcagctcaa aatgcccagc cactgccttt ctgctcagat gctggcacct ccgcccccgg     1380



ggctgccacg gctggcgctc ccccctgcca ccaaacccgc caccacctcc gagggaggag     1440



ccacgtcgcc gacctcgcct tcctactctc cgcccgacac gtcccctgca aaccgttcct     1500



ttgtgggatt aggaccaagg gatcctgcgg gcatttatca ggcacagtcc tggtatctgg     1560



gatagcaaag gtcttcttcc ctcgcccctt ctccatcgtc ccaggaatcc cagggggcag     1620



cacagccggc ccccggccca cgttttcggt ggaaaattag agtgaacaag aacacccctg     1680



ccgactccca gcccggccaa aaagacaaaa cacatagacg cacacactca ggaggaaaag     1740



aaaaaacaaa ggcagaagaa gaagaagaag aaataaaaac ccacccaagc aagaagacaa     1800



aaggtaaaga cgcaacgttt ccaactctcg ggacgccaag gccgcaggac tggagggcca     1860



ggccccgcca cccccacggg agacccggga cagggcgtct tcctaagtta ttcatctcct     1920



ctccgcctgc tgctcgggaa ggacagacgc cggccgcccg cccgcgcccc ggaggccctg     1980



gctctgtccg gagaccaggt gagcacagcc tggagcctgt gcccagggcc gacaggcgcg     2040



acacccagca aggccacctc tccccgggcc cccgcgcctc tgccggacac ggaccggccc     2100



ctcagccccc accgaggacg cagccactgg ggggaaaggg agacacagcg gaccccggcc     2160



gggcagcgga gaccgcagag gcgggcaggg tggggcaggc gagtggtgtc gcgggggtgc     2220



gtggcgcttg cgagccctgg ccaggggagg aagtgaggcc caggcacctg ctgcccctcg     2280



agggggccct gcctgccgcg gggcctcccc acaagcccct cccaaagcgc cggccgactc     2340



gctgtctcgc tggggactct ttcagccctc gcgcccgccc gtttgggagg agaagtctct     2400



a                                                                     2401





<210>  171

<211>  499

<212>  PRT

<213>  Homo sapiens



<400>  171



Met Asp Glu Phe His Pro Phe Ile Glu Ala Leu Leu Pro His Val Arg 

1               5                   10                  15      





Ala Phe Ala Tyr Thr Trp Phe Asn Leu Gln Ala Arg Lys Arg Lys Tyr 

            20                  25                  30          





Phe Lys Lys His Glu Lys Arg Met Ser Lys Asp Glu Glu Arg Ala Val 

        35                  40                  45              





Lys Asp Glu Leu Leu Gly Glu Lys Pro Glu Val Lys Gln Lys Trp Ala 

    50                  55                  60                  





Ser Arg Leu Leu Ala Lys Leu Arg Lys Asp Ile Arg Pro Glu Cys Arg 

65                  70                  75                  80  





Glu Asp Phe Val Leu Ser Ile Thr Gly Lys Lys Ala Pro Gly Cys Val 

                85                  90                  95      





Leu Ser Asn Pro Asp Gln Lys Gly Lys Met Arg Arg Ile Asp Cys Leu 

            100                 105                 110         





Arg Gln Ala Asp Lys Val Trp Arg Leu Asp Leu Val Met Val Ile Leu 

        115                 120                 125             





Phe Lys Gly Ile Pro Leu Glu Ser Thr Asp Gly Glu Arg Leu Val Lys 

    130                 135                 140                 





Ala Ala Gln Cys Gly His Pro Val Leu Cys Val Gln Pro His His Ile 

145                 150                 155                 160 





Gly Val Ala Val Lys Glu Leu Asp Leu Tyr Leu Ala Tyr Phe Val Arg 

                165                 170                 175     





Glu Arg Asp Ala Glu Gln Ser Gly Ser Pro Arg Thr Gly Met Gly Ser 

            180                 185                 190         





Asp Gln Glu Asp Ser Lys Pro Ile Thr Leu Asp Thr Thr Asp Phe Gln 

        195                 200                 205             





Glu Ser Phe Val Thr Ser Gly Val Phe Ser Val Thr Glu Leu Ile Gln 

    210                 215                 220                 





Val Ser Arg Thr Pro Val Val Thr Gly Thr Gly Pro Asn Phe Ser Leu 

225                 230                 235                 240 





Gly Glu Leu Gln Gly His Leu Ala Tyr Asp Leu Asn Pro Ala Ser Thr 

                245                 250                 255     





Gly Leu Arg Arg Thr Leu Pro Ser Thr Ser Ser Ser Gly Ser Lys Arg 

            260                 265                 270         





His Lys Ser Gly Ser Met Glu Glu Asp Val Asp Thr Ser Pro Gly Gly 

        275                 280                 285             





Asp Tyr Tyr Thr Ser Pro Ser Ser Pro Thr Ser Ser Ser Arg Asn Trp 

    290                 295                 300                 





Thr Glu Asp Met Glu Gly Gly Ile Ser Ser Pro Val Lys Lys Thr Glu 

305                 310                 315                 320 





Met Asp Lys Ser Pro Phe Asn Ser Pro Ser Pro Gln Asp Ser Pro Arg 

                325                 330                 335     





Leu Ser Ser Phe Thr Gln His His Arg Pro Val Ile Ala Val His Ser 

            340                 345                 350         





Gly Ile Ala Arg Ser Pro His Pro Ser Ser Ala Leu His Phe Pro Thr 

        355                 360                 365             





Thr Ser Ile Leu Pro Gln Thr Ala Ser Thr Tyr Phe Pro His Thr Ala 

    370                 375                 380                 





Ile Arg Tyr Pro Pro His Leu Asn Pro Gln Asp Pro Leu Lys Asp Leu 

385                 390                 395                 400 





Val Ser Leu Ala Cys Asp Pro Ala Ser Gln Gln Pro Gly Pro Leu Asn 

                405                 410                 415     





Gly Ser Gly Gln Leu Lys Met Pro Ser His Cys Leu Ser Ala Gln Met 

            420                 425                 430         





Leu Ala Pro Pro Pro Pro Gly Leu Pro Arg Leu Ala Leu Pro Pro Ala 

        435                 440                 445             





Thr Lys Pro Ala Thr Thr Ser Glu Gly Gly Ala Thr Ser Pro Thr Ser 

    450                 455                 460                 





Pro Ser Tyr Ser Pro Pro Asp Thr Ser Pro Ala Asn Arg Ser Phe Val 

465                 470                 475                 480 





Gly Leu Gly Pro Arg Asp Pro Ala Gly Ile Tyr Gln Ala Gln Ser Trp 

                485                 490                 495     





Tyr Leu Gly 

            





<210>  172

<211>  7011

<212>  DNA

<213>  Homo sapiens



<400>  172

agttacatca gcctgggcag atgtctaagg atatgagacc gggggaagaa aaagttagaa       60



tctgtagcag aaggacgaag cttgccacct gcctactggg ctgagctttt aatgtgattt      120



acatttctaa gctctatgta ggtgccctgg aaatggtggt cttcattaat gcaaagatta      180



agtctttaat taaacttttt aagaagaaaa cggtttccaa cctagatgag gaaagccgat      240



ggacagtcca ctacactgcc ccgtggcacc agcaggagaa tgtgttcctt cccaccacaa      300



gacccccctg tgttgaggac ctgcaccgcc aagccaagct caacctcaaa tcagtactga      360



gggaatgcga taagttgcgg catgatggct accgcagttc tcagtactac tctcagggac      420



ccacctttgc ggccaacgcc agcccattct gtgatgatta ccaagatgaa gatgaagaaa      480



cagatcaaaa gtgttctctg tcttcatcag aagaagaaag atttatttcc atcaggagac      540



ctaaaacacc agcctcaagt gacttctccg accttaatac tcagacgaac tggaccaagt      600



cgcttccact gccaacacca gaagagaaga tgcgacagca agcccaaaca gtccaggctg      660



acgtggtgcc tattaacata actggggaga atttcgatcg ccaggccagc cttcggcggt      720



ctctaattta cacagacact ctggtaagac gaccgaagaa agtcaaaagg agaaagacta      780



ttacaggagt ccctgacaac atacagaagg agctagcatc aggcactggc caagatgatg      840



ctgatggcca ctcagtgtac acccctgatc actactctac actaggaagg ttcaatagct      900



gtcggtctgc tgggcagcgc tcagaaacca gggactccag ctgtcagacg gaggatgtga      960



aggtcgtacc accttccatg aggagaatca gggcacagaa ggggcaaggc attgctgccc     1020



agatgggcca cttctcaggt tcctctggca acatgtctgt gctgagcgat tctgcaggga     1080



tcgtattccc ttcccgcctt gacagtgatg ctggcttcca tagtcttccg cgttctggag     1140



caagggcaaa cattcagtcc cttgagccga ggctgggtgc cctcggccct gcaggagaca     1200



tgaatggcac tttcctctac cagagaggtc acccacaagc agatgaaaac ttaggccatt     1260



taggaggtgc ctcagggact ggaacacttt tgagacccaa atcccaggag ttgagacact     1320



tcgagagtga aaatataatg agcccagcgt gtgtggtttc tcctcatgca acctactcca     1380



ccagcatcat cccaaatgcc acactgtctt cctcttccga ggtcatcgct attcccactg     1440



ctcagagtgc gggacagcgg gaaagtaaaa gttctggctc atcacatgca aggataaaat     1500



ccagagacca cctcatctcc aggcatgctg tgaaaggtga tcctcagtct cccggtcgcc     1560



actggaatga gggccatgcc accattcttt cacaggactt agaccctcat tcccctggtg     1620



aacccgcact gttgtccctc tgtgactcag ccgtccctct aaatgctcca gcaaataggg     1680



agaatgggtc ccaagctatg ccgtataatt gtagaaacaa cctggccttc ccagcccacc     1740



cccaagatgt ggatggcaag agtgaatcta gttattcagg gggcggaggg cacagcagct     1800



cggagccctg ggaatacaaa tcctcaggta atggaagggc atcccccctg aagccgcatt     1860



tagcaactcc tggctattcc actcccacaa gtaacatgag cagctgcagt ttggaccaaa     1920



cgtccaacaa agaggatgct gggtcgctgt attctgagga ccacgatggc tactgtgcat     1980



ctgtgcacac tgactctgga catggatctg ggaatctgtg caatagcagt gatggctttg     2040



ggaaccccag gcacagcgtg atcaatgttt ttgttggaag agctcagaaa aaccaagggg     2100



accggtccaa ttaccaggat aaatccctat caagaaacat ctctttgaag aaagcaaaga     2160



agcctcccct gccaccctcc cggacagact ccctccgcag gattcccaag aagagcagcc     2220



agtgcaacgg gcaggtgctc aacgagagcc tgatcgccac actccagcac tcgctgcagc     2280



tgagcctccc aggcaagagt ggcagctcgc cctcccagag cccctgcagt gacttggaag     2340



agccctggct gccccgctcc cggagccaga gcacagttag tgctggcagc agcatgactt     2400



ccgccaccac ccccaatgtc tactccctgt gcggggccac gccatcgcag agtgacacaa     2460



gcagcgtcaa gtcagagtac acggacccct ggggttatta cattgactac acgggcatgc     2520



aggaagatcc ggggaacccg gcagggggct gttcaaccag cagtggggtg cccactggga     2580



acgggccagt ccgccatgtc caagaagggt ccagagccac aatgccccaa gtgcccggtg     2640



gttcagtcaa accaaagatc atgtcaccag agaagtcaca cagagtcatt tctccatcca     2700



gtgggtattc cagccagtcg aatacaccca cagcactcac ccctgtgcct gtgtttttaa     2760



aatcagtgtc accagcaaac gggaagggga agcccaagcc caaggtacca gaaaggaagt     2820



cctctctgat atcttcagta tccatttcct catcgtccac ttctctttct tctagtactt     2880



ctactgaagg aagtggcact atgaagaagc tggatccagc cgtgggctct cccccggctc     2940



ctcctcctcc tcctgttccc tctcctccat tcccttgtcc tgcagacagg tctcctttcc     3000



ttcctccccc acctcctgtc acagattgct cccagggctc tcctctgcct cactctcctg     3060



tgttcccccc tccgccgcca gaagctctca ttcctttctg ctccccacct gattggtgcc     3120



tttctcctcc ccgccctgca ctgagcccca ttcttccaga ttcacctgtg tccttgccat     3180



tgcccccacc tctcttacct tcctcggaac ccccacctgc cccacctctt gaccccaaat     3240



tcatgaaaga caccaggccg cctttcacaa attctggcca gccagaatcc tcccggggat     3300



ccttgaggcc gccttctacc aaggaggaga ccagcaggcc ccccatgccc ctgataacca     3360



cggaagcatt gcagatggtg cagttgaggc ccgtgagaaa gaactcaggc gctgaggcgg     3420



cacagttgtc tgaacgaaca gctcaggaac aacgaactcc agttgctcca cagtaccact     3480



taaagccatc tgctttcctg aaatcccgaa atagcacaaa tgaaatggag agtgaaagcc     3540



agcctgcctc tgtgacaagc tcgcttccga cgcctgccaa gagctcgagt cagggtgacc     3600



atggcagtgc ggctgagcgt ggtggccctg tgagccgcag ccctggagct ccaagcgctg     3660



gggaggcaga ggctcggccc agccccagca ccaccccact cccagactct tcacccagca     3720



ggaagccacc ccccatttcc aagaagccca aactgttcct ggtggtacca cctccgcaga     3780



aagattttgc agtggagccc gcagagaacg tgagcgaagc cctccgagct gtgcccagcc     3840



ccacgacggg agaggagggc tctgtgcaca gcagggaggc aaaagagagt tctgcagccc     3900



aagctggctc tcatgccacg caccctggca cctcggttct tgagggagga gctgcaggat     3960



ccatgtctcc cagcagagtg gaagccaatg tccccatggt tcagcctgat gtctcaccag     4020



cccccaagca ggaggagcca gccgagaaca gtgcggatac tgggggcgat ggggagagct     4080



gcctatctca acaggacgga gcagctgggg tgccggagac caacgcagcc ggttcatcct     4140



cagaggcctg tgacttcctc aaggaagacg ggaatgatga ggtaatgacc cccagtcgac     4200



ccaggaccac agaagacctt tttgcagcta ttcacagatc caaaaggaaa gtcctcggcc     4260



gtagagattc agatgatgac cactcccgaa accattctcc ctccccgccc gtgacaccca     4320



ccggcgctgc cccaagcctg gcctctccaa agcaagtggg gtcgattcag agaagcatcc     4380



gaaagagcag caccagcagt gacaacttca aagctctgct gctgaaaaag ggcagtcgtt     4440



cagacaccag cgcccgcatg tctgcagcag agatgctcaa gaacacagac cctagattcc     4500



agaggtcgag gtcagagcct tccccagatg cccccgagag cccgtcaagc tgctccccaa     4560



gcaagaacag aagggcgcag gaggagtggg ccaagaacga aggcttgatg cctcggagtc     4620



tgtccttttc cggccccagg tacggccgca gccgaacgcc gccttctgcc gccagcagca     4680



ggtacagcat gcggaaccgg atccagagca gccccatgac cgtcatctcg gagggagaag     4740



gggaagccgt ggagcctgtg gacagcatag cccgcggggc tctgggcgct gcggagggat     4800



gttccctgga cggactggcg agggaggaga tggacgaggg cggcctgctc tgtggggagg     4860



ggcctgccgc ctccctgcag ccccaggccc ccggccctgt ggatgggaca gccagtgcag     4920



agggcagaga gccctcccca cagtgtggcg gttctctgag cgaggagagt tagggccaag     4980



aacgtaactc tcccaggtga cacgggggga gacgagcaat gcagcactct aggaagcctg     5040



ctaggcgccc ttccctggct cacccgggga gcccactctg cttctgtgct gtgggccccg     5100



gggttgccag ccctgcagtg tgagtgaacg gttatttagg actcacctgg cacttgccct     5160



gtggcttaag aacaagtaga agcttaaact tctgaaagtg cttcccgggg aagatttttt     5220



tttttttttt ttttttttgc taaatgctgg gtgtgtatgt gtgcattttc cacacttttt     5280



aatttttaaa aaatacacat atacacaaac aacatgtaca gaaatagaag aaagcaagcc     5340



agacttaagc ttggtagagt aacggagtcc tctggtctag gcggtaattg ctttcagaga     5400



attacgttta tagaaatcag cgagttttgt aagaaaggag aagatgttac ttcaagaaag     5460



aggcagtaga gttgctggtt cttaatgcac agaacacaca gatatatgca cacgtgtgct     5520



gctgaggtga ggcaggtctg gtgagcacgg agaggctggg aaggggctaa gtgactaatt     5580



ggttcaggta cttttttctg ggggaggtag actttgcttc ttttttgtaa aaatgacaaa     5640



cgtagaagtg gcaatgctgt aacctggtgc ctgctgctgt gcagccacat acacacaatt     5700



gtagcctgat ttttagaagt gtgggtaatt ttttaatgaa tttcctcctt gagtagcagc     5760



tgaggtcatt gacaactgaa gtgatggtgt ggacatagag agaggggaag ggttggaaag     5820



gagtaagtga tacactgctg gaatttgttt cctgcctatg aaataaaatt atttttcaga     5880



attaaatttg aaaacttgca ctacagaact atgggtggag cttttccttt tacaacagtt     5940



tttttttttt ttttttttta accagagttt aaacttccat taggcaattt cctgtcactt     6000



gaaatgtcaa catttgctaa cttttggata tccttttggt tacaccaaag aaaaagttat     6060



ggctattttt ttttccttga actgcctaca gtatcatgtc ctaattcaga aagatttatc     6120



aaaatctatt atatattatc ttactttgaa gaaaatgctg aatagctctt gttagtcaaa     6180



taaactgata aaaattggta gggcctggct atcaattagc cctgggaaat gaatttttag     6240



attaaaaagg tttttttgca tcatttggtt tgtgcatttt tatatttgtt tataaataat     6300



tgagttgcta attacttcta atcttctcca atcagatttt caacaatttt agacatggga     6360



cacacgtgtg tgaagtcttt attttaatgt aataatctca ttacccccac ccttactccc     6420



ttaacttcca tgtacttaga ctcctttatt tgttaaataa actagagtat tgtcttcttc     6480



attagaagga cctaggatga caatgcggag agtcttggtc tgaatctagt gcgactacca     6540



cctgccagct tttggggggt atggaaatac tatctaaaag ttggactgca tgggtcaaat     6600



cattatgaga cttataaact aaaactttag atacccatat agaaatgtct ttgaggcaaa     6660



aacaaaccta aagaatgaag gctctttccc ttctctgaaa aaaacaaaac actgctcttc     6720



acacaaccgg aagtcaagac cagagatttg gagcaattgt ctactaattt ggcacaaaga     6780



tcgtttcttt agaaaagtgg cattggcttt tgaatatgaa atcttctcat agctgcctaa     6840



aaaagactag aatgtatatg gatatcagaa acctttaata atacataatt tatgcaaaga     6900



taagataaag caacataaca ctaattataa aactattttt aaatccccat ttttaatgaa     6960



aaatatacat ttgtatttaa tttcctttga ataaaacaat tgtaaagtaa a              7011





<210>  173

<211>  1606

<212>  PRT

<213>  Homo sapiens



<400>  173



Met Val Val Phe Ile Asn Ala Lys Ile Lys Ser Leu Ile Lys Leu Phe 

1               5                   10                  15      





Lys Lys Lys Thr Val Ser Asn Leu Asp Glu Glu Ser Arg Trp Thr Val 

            20                  25                  30          





His Tyr Thr Ala Pro Trp His Gln Gln Glu Asn Val Phe Leu Pro Thr 

        35                  40                  45              





Thr Arg Pro Pro Cys Val Glu Asp Leu His Arg Gln Ala Lys Leu Asn 

    50                  55                  60                  





Leu Lys Ser Val Leu Arg Glu Cys Asp Lys Leu Arg His Asp Gly Tyr 

65                  70                  75                  80  





Arg Ser Ser Gln Tyr Tyr Ser Gln Gly Pro Thr Phe Ala Ala Asn Ala 

                85                  90                  95      





Ser Pro Phe Cys Asp Asp Tyr Gln Asp Glu Asp Glu Glu Thr Asp Gln 

            100                 105                 110         





Lys Cys Ser Leu Ser Ser Ser Glu Glu Glu Arg Phe Ile Ser Ile Arg 

        115                 120                 125             





Arg Pro Lys Thr Pro Ala Ser Ser Asp Phe Ser Asp Leu Asn Thr Gln 

    130                 135                 140                 





Thr Asn Trp Thr Lys Ser Leu Pro Leu Pro Thr Pro Glu Glu Lys Met 

145                 150                 155                 160 





Arg Gln Gln Ala Gln Thr Val Gln Ala Asp Val Val Pro Ile Asn Ile 

                165                 170                 175     





Thr Gly Glu Asn Phe Asp Arg Gln Ala Ser Leu Arg Arg Ser Leu Ile 

            180                 185                 190         





Tyr Thr Asp Thr Leu Val Arg Arg Pro Lys Lys Val Lys Arg Arg Lys 

        195                 200                 205             





Thr Ile Thr Gly Val Pro Asp Asn Ile Gln Lys Glu Leu Ala Ser Gly 

    210                 215                 220                 





Thr Gly Gln Asp Asp Ala Asp Gly His Ser Val Tyr Thr Pro Asp His 

225                 230                 235                 240 





Tyr Ser Thr Leu Gly Arg Phe Asn Ser Cys Arg Ser Ala Gly Gln Arg 

                245                 250                 255     





Ser Glu Thr Arg Asp Ser Ser Cys Gln Thr Glu Asp Val Lys Val Val 

            260                 265                 270         





Pro Pro Ser Met Arg Arg Ile Arg Ala Gln Lys Gly Gln Gly Ile Ala 

        275                 280                 285             





Ala Gln Met Gly His Phe Ser Gly Ser Ser Gly Asn Met Ser Val Leu 

    290                 295                 300                 





Ser Asp Ser Ala Gly Ile Val Phe Pro Ser Arg Leu Asp Ser Asp Ala 

305                 310                 315                 320 





Gly Phe His Ser Leu Pro Arg Ser Gly Ala Arg Ala Asn Ile Gln Ser 

                325                 330                 335     





Leu Glu Pro Arg Leu Gly Ala Leu Gly Pro Ala Gly Asp Met Asn Gly 

            340                 345                 350         





Thr Phe Leu Tyr Gln Arg Gly His Pro Gln Ala Asp Glu Asn Leu Gly 

        355                 360                 365             





His Leu Gly Gly Ala Ser Gly Thr Gly Thr Leu Leu Arg Pro Lys Ser 

    370                 375                 380                 





Gln Glu Leu Arg His Phe Glu Ser Glu Asn Ile Met Ser Pro Ala Cys 

385                 390                 395                 400 





Val Val Ser Pro His Ala Thr Tyr Ser Thr Ser Ile Ile Pro Asn Ala 

                405                 410                 415     





Thr Leu Ser Ser Ser Ser Glu Val Ile Ala Ile Pro Thr Ala Gln Ser 

            420                 425                 430         





Ala Gly Gln Arg Glu Ser Lys Ser Ser Gly Ser Ser His Ala Arg Ile 

        435                 440                 445             





Lys Ser Arg Asp His Leu Ile Ser Arg His Ala Val Lys Gly Asp Pro 

    450                 455                 460                 





Gln Ser Pro Gly Arg His Trp Asn Glu Gly His Ala Thr Ile Leu Ser 

465                 470                 475                 480 





Gln Asp Leu Asp Pro His Ser Pro Gly Glu Pro Ala Leu Leu Ser Leu 

                485                 490                 495     





Cys Asp Ser Ala Val Pro Leu Asn Ala Pro Ala Asn Arg Glu Asn Gly 

            500                 505                 510         





Ser Gln Ala Met Pro Tyr Asn Cys Arg Asn Asn Leu Ala Phe Pro Ala 

        515                 520                 525             





His Pro Gln Asp Val Asp Gly Lys Ser Glu Ser Ser Tyr Ser Gly Gly 

    530                 535                 540                 





Gly Gly His Ser Ser Ser Glu Pro Trp Glu Tyr Lys Ser Ser Gly Asn 

545                 550                 555                 560 





Gly Arg Ala Ser Pro Leu Lys Pro His Leu Ala Thr Pro Gly Tyr Ser 

                565                 570                 575     





Thr Pro Thr Ser Asn Met Ser Ser Cys Ser Leu Asp Gln Thr Ser Asn 

            580                 585                 590         





Lys Glu Asp Ala Gly Ser Leu Tyr Ser Glu Asp His Asp Gly Tyr Cys 

        595                 600                 605             





Ala Ser Val His Thr Asp Ser Gly His Gly Ser Gly Asn Leu Cys Asn 

    610                 615                 620                 





Ser Ser Asp Gly Phe Gly Asn Pro Arg His Ser Val Ile Asn Val Phe 

625                 630                 635                 640 





Val Gly Arg Ala Gln Lys Asn Gln Gly Asp Arg Ser Asn Tyr Gln Asp 

                645                 650                 655     





Lys Ser Leu Ser Arg Asn Ile Ser Leu Lys Lys Ala Lys Lys Pro Pro 

            660                 665                 670         





Leu Pro Pro Ser Arg Thr Asp Ser Leu Arg Arg Ile Pro Lys Lys Ser 

        675                 680                 685             





Ser Gln Cys Asn Gly Gln Val Leu Asn Glu Ser Leu Ile Ala Thr Leu 

    690                 695                 700                 





Gln His Ser Leu Gln Leu Ser Leu Pro Gly Lys Ser Gly Ser Ser Pro 

705                 710                 715                 720 





Ser Gln Ser Pro Cys Ser Asp Leu Glu Glu Pro Trp Leu Pro Arg Ser 

                725                 730                 735     





Arg Ser Gln Ser Thr Val Ser Ala Gly Ser Ser Met Thr Ser Ala Thr 

            740                 745                 750         





Thr Pro Asn Val Tyr Ser Leu Cys Gly Ala Thr Pro Ser Gln Ser Asp 

        755                 760                 765             





Thr Ser Ser Val Lys Ser Glu Tyr Thr Asp Pro Trp Gly Tyr Tyr Ile 

    770                 775                 780                 





Asp Tyr Thr Gly Met Gln Glu Asp Pro Gly Asn Pro Ala Gly Gly Cys 

785                 790                 795                 800 





Ser Thr Ser Ser Gly Val Pro Thr Gly Asn Gly Pro Val Arg His Val 

                805                 810                 815     





Gln Glu Gly Ser Arg Ala Thr Met Pro Gln Val Pro Gly Gly Ser Val 

            820                 825                 830         





Lys Pro Lys Ile Met Ser Pro Glu Lys Ser His Arg Val Ile Ser Pro 

        835                 840                 845             





Ser Ser Gly Tyr Ser Ser Gln Ser Asn Thr Pro Thr Ala Leu Thr Pro 

    850                 855                 860                 





Val Pro Val Phe Leu Lys Ser Val Ser Pro Ala Asn Gly Lys Gly Lys 

865                 870                 875                 880 





Pro Lys Pro Lys Val Pro Glu Arg Lys Ser Ser Leu Ile Ser Ser Val 

                885                 890                 895     





Ser Ile Ser Ser Ser Ser Thr Ser Leu Ser Ser Ser Thr Ser Thr Glu 

            900                 905                 910         





Gly Ser Gly Thr Met Lys Lys Leu Asp Pro Ala Val Gly Ser Pro Pro 

        915                 920                 925             





Ala Pro Pro Pro Pro Pro Val Pro Ser Pro Pro Phe Pro Cys Pro Ala 

    930                 935                 940                 





Asp Arg Ser Pro Phe Leu Pro Pro Pro Pro Pro Val Thr Asp Cys Ser 

945                 950                 955                 960 





Gln Gly Ser Pro Leu Pro His Ser Pro Val Phe Pro Pro Pro Pro Pro 

                965                 970                 975     





Glu Ala Leu Ile Pro Phe Cys Ser Pro Pro Asp Trp Cys Leu Ser Pro 

            980                 985                 990         





Pro Arg Pro Ala Leu Ser Pro Ile  Leu Pro Asp Ser Pro  Val Ser Leu 

        995                 1000                 1005             





Pro Leu  Pro Pro Pro Leu Leu  Pro Ser Ser Glu Pro  Pro Pro Ala 

    1010                 1015                 1020             





Pro Pro  Leu Asp Pro Lys Phe  Met Lys Asp Thr Arg  Pro Pro Phe 

    1025                 1030                 1035             





Thr Asn  Ser Gly Gln Pro Glu  Ser Ser Arg Gly Ser  Leu Arg Pro 

    1040                 1045                 1050             





Pro Ser  Thr Lys Glu Glu Thr  Ser Arg Pro Pro Met  Pro Leu Ile 

    1055                 1060                 1065             





Thr Thr  Glu Ala Leu Gln Met  Val Gln Leu Arg Pro  Val Arg Lys 

    1070                 1075                 1080             





Asn Ser  Gly Ala Glu Ala Ala  Gln Leu Ser Glu Arg  Thr Ala Gln 

    1085                 1090                 1095             





Glu Gln  Arg Thr Pro Val Ala  Pro Gln Tyr His Leu  Lys Pro Ser 

    1100                 1105                 1110             





Ala Phe  Leu Lys Ser Arg Asn  Ser Thr Asn Glu Met  Glu Ser Glu 

    1115                 1120                 1125             





Ser Gln  Pro Ala Ser Val Thr  Ser Ser Leu Pro Thr  Pro Ala Lys 

    1130                 1135                 1140             





Ser Ser  Ser Gln Gly Asp His  Gly Ser Ala Ala Glu  Arg Gly Gly 

    1145                 1150                 1155             





Pro Val  Ser Arg Ser Pro Gly  Ala Pro Ser Ala Gly  Glu Ala Glu 

    1160                 1165                 1170             





Ala Arg  Pro Ser Pro Ser Thr  Thr Pro Leu Pro Asp  Ser Ser Pro 

    1175                 1180                 1185             





Ser Arg  Lys Pro Pro Pro Ile  Ser Lys Lys Pro Lys  Leu Phe Leu 

    1190                 1195                 1200             





Val Val  Pro Pro Pro Gln Lys  Asp Phe Ala Val Glu  Pro Ala Glu 

    1205                 1210                 1215             





Asn Val  Ser Glu Ala Leu Arg  Ala Val Pro Ser Pro  Thr Thr Gly 

    1220                 1225                 1230             





Glu Glu  Gly Ser Val His Ser  Arg Glu Ala Lys Glu  Ser Ser Ala 

    1235                 1240                 1245             





Ala Gln  Ala Gly Ser His Ala  Thr His Pro Gly Thr  Ser Val Leu 

    1250                 1255                 1260             





Glu Gly  Gly Ala Ala Gly Ser  Met Ser Pro Ser Arg  Val Glu Ala 

    1265                 1270                 1275             





Asn Val  Pro Met Val Gln Pro  Asp Val Ser Pro Ala  Pro Lys Gln 

    1280                 1285                 1290             





Glu Glu  Pro Ala Glu Asn Ser  Ala Asp Thr Gly Gly  Asp Gly Glu 

    1295                 1300                 1305             





Ser Cys  Leu Ser Gln Gln Asp  Gly Ala Ala Gly Val  Pro Glu Thr 

    1310                 1315                 1320             





Asn Ala  Ala Gly Ser Ser Ser  Glu Ala Cys Asp Phe  Leu Lys Glu 

    1325                 1330                 1335             





Asp Gly  Asn Asp Glu Val Met  Thr Pro Ser Arg Pro  Arg Thr Thr 

    1340                 1345                 1350             





Glu Asp  Leu Phe Ala Ala Ile  His Arg Ser Lys Arg  Lys Val Leu 

    1355                 1360                 1365             





Gly Arg  Arg Asp Ser Asp Asp  Asp His Ser Arg Asn  His Ser Pro 

    1370                 1375                 1380             





Ser Pro  Pro Val Thr Pro Thr  Gly Ala Ala Pro Ser  Leu Ala Ser 

    1385                 1390                 1395             





Pro Lys  Gln Val Gly Ser Ile  Gln Arg Ser Ile Arg  Lys Ser Ser 

    1400                 1405                 1410             





Thr Ser  Ser Asp Asn Phe Lys  Ala Leu Leu Leu Lys  Lys Gly Ser 

    1415                 1420                 1425             





Arg Ser  Asp Thr Ser Ala Arg  Met Ser Ala Ala Glu  Met Leu Lys 

    1430                 1435                 1440             





Asn Thr  Asp Pro Arg Phe Gln  Arg Ser Arg Ser Glu  Pro Ser Pro 

    1445                 1450                 1455             





Asp Ala  Pro Glu Ser Pro Ser  Ser Cys Ser Pro Ser  Lys Asn Arg 

    1460                 1465                 1470             





Arg Ala  Gln Glu Glu Trp Ala  Lys Asn Glu Gly Leu  Met Pro Arg 

    1475                 1480                 1485             





Ser Leu  Ser Phe Ser Gly Pro  Arg Tyr Gly Arg Ser  Arg Thr Pro 

    1490                 1495                 1500             





Pro Ser  Ala Ala Ser Ser Arg  Tyr Ser Met Arg Asn  Arg Ile Gln 

    1505                 1510                 1515             





Ser Ser  Pro Met Thr Val Ile  Ser Glu Gly Glu Gly  Glu Ala Val 

    1520                 1525                 1530             





Glu Pro  Val Asp Ser Ile Ala  Arg Gly Ala Leu Gly  Ala Ala Glu 

    1535                 1540                 1545             





Gly Cys  Ser Leu Asp Gly Leu  Ala Arg Glu Glu Met  Asp Glu Gly 

    1550                 1555                 1560             





Gly Leu  Leu Cys Gly Glu Gly  Pro Ala Ala Ser Leu  Gln Pro Gln 

    1565                 1570                 1575             





Ala Pro  Gly Pro Val Asp Gly  Thr Ala Ser Ala Glu  Gly Arg Glu 

    1580                 1585                 1590             





Pro Ser  Pro Gln Cys Gly Gly  Ser Leu Ser Glu Glu  Ser 

    1595                 1600                 1605     





<210>  174

<211>  1419

<212>  DNA

<213>  Homo sapiens



<400>  174

tactcgctgt gactgtgtgc atgtggctct ctccctgggc ctcagttttc ccatgtgagg       60



aacggggata gtaacacagg ctggctgtga agatgaacat taatccatgc ctggtgcttt      120



gtgagtgctc actgagtatt agccttgatg cagacccact ggtttctcct tttgccactg      180



ggccctgccc tggagctccc agggaggtgg tggcgatgca gagcgacgtg ggtcagggat      240



tccccatgca gtccaactgg agggctcccg tgcatgcgtg cacatcaggg gcggtaagga      300



agggctggcc ggggtgtggg aggaggcgac acaagatggg aggtggccct gtctcttggg      360



agcaaaggca gaaggaggtg gaggcagctc agggctcgga ggagaggggt ccgggctcct      420



tggctgtgtc cctgctgtct ctcgctgtgg gtattcaccg aatctctccc atcctcggtt      480



ttcacatctg ctgcatgcag gtcctcatgg ttctcaagtg aggcaggtgg tgagcccatc      540



aggccagtgc ccagggctta ttctggggac agctcctgga gaggaagggc tgcctcccta      600



aggactcctg ccctgccctg ggtgcaaggg gttccacctg ctgcccctcc cccactcccc      660



agctcgcctc aggcggatag ttcccctctc actccaaata agagccacaa tgctgacagt      720



ggcccccaag gccctgccca gcggtcccca gcttcctcta gctacatctc ccggccctcc      780



ccttcaccca ctcctgtagg cgcctcgaac gcgcctcagc cctgctcctc ccctgcctgc      840



agcgttcctc cccaggtctc ccccggctct ctcacctgct tccggttttg ctcagactgc      900



gctgcctcag tgcgcccttc tgtcaccatc ctgtgtatag tcggaaaccc ctgctccctt      960



tccctgcact gaatcttccg tgtgctcctt ttctccatgg catttgttag ctttggctat     1020



cctgtctaat ttgcgtatgt atttattttt tattttgctg cctgttccct cattccccca     1080



actccccaat ggcagggagt tctgttttgg tcactgctga atccctggtg acccgagcag     1140



tgatgatgca gagttgttgt gatatttgtg gaatgaatga atgcaggatt ttttgtttta     1200



ccttcacttg gcacaaatgc tgtggttctg ttcaccactc ccccctgaag taatgaaagt     1260



tatgggccca tccctgtgct gagtggagct ggggacacag tgggggctag gacagactgt     1320



atccctgcct tgtggaaccc acagtccagt gggagaggcg acattaccca catagtcatg     1380



caggtgacag aggcaagtgc tgtgagggga agggaaggc                            1419





<210>  175

<211>  142

<212>  PRT

<213>  Homo sapiens



<400>  175



Met Asn Ile Asn Pro Cys Leu Val Leu Cys Glu Cys Ser Leu Ser Ile 

1               5                   10                  15      





Ser Leu Asp Ala Asp Pro Leu Val Ser Pro Phe Ala Thr Gly Pro Cys 

            20                  25                  30          





Pro Gly Ala Pro Arg Glu Val Val Ala Met Gln Ser Asp Val Gly Gln 

        35                  40                  45              





Gly Phe Pro Met Gln Ser Asn Trp Arg Ala Pro Val His Ala Cys Thr 

    50                  55                  60                  





Ser Gly Ala Val Arg Lys Gly Trp Pro Gly Cys Gly Arg Arg Arg His 

65                  70                  75                  80  





Lys Met Gly Gly Gly Pro Val Ser Trp Glu Gln Arg Gln Lys Glu Val 

                85                  90                  95      





Glu Ala Ala Gln Gly Ser Glu Glu Arg Gly Pro Gly Ser Leu Ala Val 

            100                 105                 110         





Ser Leu Leu Ser Leu Ala Val Gly Ile His Arg Ile Ser Pro Ile Leu 

        115                 120                 125             





Gly Phe His Ile Cys Cys Met Gln Val Leu Met Val Leu Lys 

    130                 135                 140         





<210>  176

<211>  1225

<212>  DNA

<213>  Homo sapiens



<400>  176

gatgacgcaa gagcccgctc tcacttttca gcggcaggcg aagggggctg aggaaaggag       60



gtgggtctag gcaggggaaa ttggggtgcc accagacgga gacagcttgg actaccagaa      120



tcaagcactc ttttggaaga gggtaatctc tctccaaaaa ctgaggacac ttaccttccc      180



catatattga gtccagctgt gtttggtggc ccaggtacta atttcaagat gccaggacgt      240



tccagttcaa attcaggttc aactggtttc atctccttca gtggtgtaga gtctgctctc      300



tcctccttga aaaacttcca agcctgtatc aactctggta tggacacagc ttctagtgtt      360



gctttggatc ttgtggaaag tcagactgaa gtgagtagtg aatatagtat ggacaaggca      420



atggttgaat ttgctacatt ggatcggcaa ctaaaccatt atgtaaaggc tgttcaatct      480



acaataaatc atgtgaaaga agaacgtcca gaaaaaatac cagatttaaa attattggta      540



gagaagaaat ttttggcttt acagagcaag aattctgatg cagactttca aaataatgaa      600



aaatttgtac agtttaaaca acagctgaaa gaactaaaga agcaatgtgg tcttcaagct      660



gacagagaag ctgacggaac agaaggagtg gatgaagata taattgtgac ccaaagtcag      720



accaacttca cctgccccat tacaaaggag gaaatgaaga agccagtgaa aaataaagtg      780



tgtggccaca cctatgaaga ggacgccatt gttcgcatga ttgagtccag gcaaaagcgg      840



aagaaaaagg cctattgccc tcaaattggc tgtagccaca cggatataag aaagtcagat      900



cttatccagg atgaagcact tagaagggca attgagaacc ataacaagaa aagacatcgt      960



cattccgagt aggaaaagcc acctgcctgc agggacacca gcagcctacc tcctacccca     1020



gctgtctgtt gagagcagtg ctgaccccag cagttaggga ctggctgcat agcatacttg     1080



ttgggggtaa aacttgttgc ttttatgtgt gcttgaaaac atttttcaaa gttacacaac     1140



agaaatgcaa tcatattgtt tatttttaag tgttctataa tgttaaataa aactttgatc     1200



atctgcagtg tcaaaaaaaa aaaaa                                           1225





<210>  177

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  177



Met Pro Gly Arg Ser Ser Ser Asn Ser Gly Ser Thr Gly Phe Ile Ser 

1               5                   10                  15      





Phe Ser Gly Val Glu Ser Ala Leu Ser Ser Leu Lys Asn Phe Gln Ala 

            20                  25                  30          





Cys Ile Asn Ser Gly Met Asp Thr Ala Ser Ser Val Ala Leu Asp Leu 

        35                  40                  45              





Val Glu Ser Gln Thr Glu Val Ser Ser Glu Tyr Ser Met Asp Lys Ala 

    50                  55                  60                  





Met Val Glu Phe Ala Thr Leu Asp Arg Gln Leu Asn His Tyr Val Lys 

65                  70                  75                  80  





Ala Val Gln Ser Thr Ile Asn His Val Lys Glu Glu Arg Pro Glu Lys 

                85                  90                  95      





Ile Pro Asp Leu Lys Leu Leu Val Glu Lys Lys Phe Leu Ala Leu Gln 

            100                 105                 110         





Ser Lys Asn Ser Asp Ala Asp Phe Gln Asn Asn Glu Lys Phe Val Gln 

        115                 120                 125             





Phe Lys Gln Gln Leu Lys Glu Leu Lys Lys Gln Cys Gly Leu Gln Ala 

    130                 135                 140                 





Asp Arg Glu Ala Asp Gly Thr Glu Gly Val Asp Glu Asp Ile Ile Val 

145                 150                 155                 160 





Thr Gln Ser Gln Thr Asn Phe Thr Cys Pro Ile Thr Lys Glu Glu Met 

                165                 170                 175     





Lys Lys Pro Val Lys Asn Lys Val Cys Gly His Thr Tyr Glu Glu Asp 

            180                 185                 190         





Ala Ile Val Arg Met Ile Glu Ser Arg Gln Lys Arg Lys Lys Lys Ala 

        195                 200                 205             





Tyr Cys Pro Gln Ile Gly Cys Ser His Thr Asp Ile Arg Lys Ser Asp 

    210                 215                 220                 





Leu Ile Gln Asp Glu Ala Leu Arg Arg Ala Ile Glu Asn His Asn Lys 

225                 230                 235                 240 





Lys Arg His Arg His Ser Glu 

                245         





<210>  178

<211>  2306

<212>  DNA

<213>  Homo sapiens



<400>  178

attcctaggc tgctggctct cagacccgca gtgaggtctg acgtcatttc ctgccgtaag       60



tatacagtgc ctccgggtcg cggtcatttt gagcccctgt ctggatgact tcttgcggct      120



gttctacccc tccccctccc cgcggtacct tgcacttttc tccctccctg ccccctctcg      180



agtccaccct ccgggccttc tgcccctgat cgcttggttt tccttgcagt cgcctgctgc      240



tgtcgtcggg aggtgggtga ggtgacgcaa acagccccgt tgttgccctc cgcgtatccc      300



ctcaccacct ttgcggccat ccacgacttt cgcaccttcc gccattttcc tgcctgtgag      360



ggtggacaga tcgcgctcgg gtctcggcct cctgagtgcc ggtgactgcg ggaggcgacg      420



gagtgcttct gggggtgtga gctggggaag ttcgtggtca cggatgcgtg tggggttgct      480



gctcagtctg taacggcagg aaagatgaat gggagggctg attttcgaga gccgaatgca      540



gaggttccaa gaccaattcc ccacataggg cctgattaca ttccaacaga ggaagaaagg      600



agagtcttcg cagaatgcaa tgatgaaagc ttctggttca gatctgtgcc tttggctgca      660



acaagtatgt tgattactca aggattaatt agtaaaggaa tactttcaag tcatcccaaa      720



tatggttcca tccctaaact tatacttgct tgtatcatgg gatactttgc tggaaaactt      780



tcttatgtga aaacttgcca agagaaattc aagaaacttg aaaattcccc ccttggagaa      840



gctttacgat caggacaagc acgacgatct tcaccacctg ggcactatta tcaaaagtca      900



aaatatgact caagtgtgag tggtcaatca tcttttgtga catccccagc agcagacaac      960



atagaaatgc ttcctcatta tgagccaatt ccattcagtt cttctatgaa tgaatctgct     1020



cccactggta ttactgatca tattgtccaa ggacctgatc ccaaccttga agaaagtcct     1080



aaaagaaaaa atattacata tgaggaatta aggaataaga acagagagtc atatgaagta     1140



tctttaacac aaaagactga cccctcagtc aggcctatgc atgaaagagt gccaaaaaaa     1200



gaagtcaaag taaacaagta tggagatact tgggatgagt gaaaaattac atcattggac     1260



atgaaggagt ttcaacatcc agcttcatct aggtggtcat gattacctgc atgctttgag     1320



ctcagcagca gtcttcataa acacatttaa aacaagatcc tgggtttttg tggtttgact     1380



tctatggtgt tttaaaaaaa cacagatttt tagtgttaat attgtgtaaa tgtactcacc     1440



ttagggattc atttgaatga tggtattata ccatgattgt atacagtttg tgaaattgtt     1500



gcaagggcaa agataactct taaaaaaccg tcgagattac aatgctctag aatcagcata     1560



taagaaaata aatgatatct gcatgttgaa ttggggtgga tggggggagc aagcataatt     1620



tttaagtgtg aagctttgca tcaagaaatt attaaaaagc tttttttctc cagtattttc     1680



tgtattatct taatgtttat ggcaaataaa atgtaaagga acatgcaaca gccctcatct     1740



tccttgattt tatggtttta ttgtttgtaa tttattgatt tatttttaag ctagttataa     1800



tcatgtaggt ataggaaata aagtcatcta taatatttct ataatatggc tataatatgg     1860



ctataaatct ataatatggc tggaggcagt gggcagtggt tcatgcctgt aatcccagca     1920



ctttgggagg ccgaagtggg aggattgcat gagtccagga gtttgagacc agcctgggca     1980



acaaagcgag accctgtctt tacaaaaaaa taaaaattag ctggcgatgg tgtcgtgtgc     2040



ctgtagtcct agttacttaa gaggctgagt tgggaggatc agttgaaccc agtggttctg     2100



ggttgcagtg agctgtggtc acaccactga actccagcct gtgcgactga gtgagaccct     2160



gtgtctaaaa aaataaaaat ataatgaatg tgatttatgt agataaattg ataatatagt     2220



aaataggtaa atgccttaaa aagcattttt aaagaatttg taaattctaa aacaataaaa     2280



atttggtata catcaaaaaa aaaaaa                                          2306





<210>  179

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  179



Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 

1               5                   10                  15      





Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 

            20                  25                  30          





Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 

        35                  40                  45              





Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 

    50                  55                  60                  





Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 

65                  70                  75                  80  





Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 

                85                  90                  95      





Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 

            100                 105                 110         





Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 

        115                 120                 125             





Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 

    130                 135                 140                 





Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 

145                 150                 155                 160 





Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 

                165                 170                 175     





Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 

            180                 185                 190         





Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 

        195                 200                 205             





Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 

    210                 215                 220                 





Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 

225                 230                 235                 240 





Asp Thr Trp Asp Glu 

                245 





<210>  180

<211>  1906

<212>  DNA

<213>  Homo sapiens



<400>  180

attcctaggc tgctggctct cagacccgca gtgaggtctg acgtcatttc ctgccgtaag       60



tatacagtgc ctccgggtcg cggtcatttt gagcccctgt ctggatgact tcttgcggct      120



gttctacccc tccccctccc cgcggtacct tgcacttttc tccctccctg ccccctctcg      180



agtccaccct ccgggccttc tgcccctgat cgcttggttt tccttgcagt cgcctgctgc      240



tgtcgtcggg aggaaagatg aatgggaggg ctgattttcg agagccgaat gcagaggttc      300



caagaccaat tccccacata gggcctgatt acattccaac agaggaagaa aggagagtct      360



tcgcagaatg caatgatgaa agcttctggt tcagatctgt gcctttggct gcaacaagta      420



tgttgattac tcaaggatta attagtaaag gaatactttc aagtcatccc aaatatggtt      480



ccatccctaa acttatactt gcttgtatca tgggatactt tgctggaaaa ctttcttatg      540



tgaaaacttg ccaagagaaa ttcaagaaac ttgaaaattc cccccttgga gaagctttac      600



gatcaggaca agcacgacga tcttcaccac ctgggcacta ttatcaaaag tcaaaatatg      660



actcaagtgt gagtggtcaa tcatcttttg tgacatcccc agcagcagac aacatagaaa      720



tgcttcctca ttatgagcca attccattca gttcttctat gaatgaatct gctcccactg      780



gtattactga tcatattgtc caagtcaaag taaacaagta tggagatact tgggatgagt      840



gaaaaattac atcattggac atgaaggagt ttcaacatcc agcttcatct aggtggtcat      900



gattacctgc atgctttgag ctcagcagca gtcttcataa acacatttaa aacaagatcc      960



tgggtttttg tggtttgact tctatggtgt tttaaaaaaa cacagatttt tagtgttaat     1020



attgtgtaaa tgtactcacc ttagggattc atttgaatga tggtattata ccatgattgt     1080



atacagtttg tgaaattgtt gcaagggcaa agataactct taaaaaaccg tcgagattac     1140



aatgctctag aatcagcata taagaaaata aatgatatct gcatgttgaa ttggggtgga     1200



tggggggagc aagcataatt tttaagtgtg aagctttgca tcaagaaatt attaaaaagc     1260



tttttttctc cagtattttc tgtattatct taatgtttat ggcaaataaa atgtaaagga     1320



acatgcaaca gccctcatct tccttgattt tatggtttta ttgtttgtaa tttattgatt     1380



tatttttaag ctagttataa tcatgtaggt ataggaaata aagtcatcta taatatttct     1440



ataatatggc tataatatgg ctataaatct ataatatggc tggaggcagt gggcagtggt     1500



tcatgcctgt aatcccagca ctttgggagg ccgaagtggg aggattgcat gagtccagga     1560



gtttgagacc agcctgggca acaaagcgag accctgtctt tacaaaaaaa taaaaattag     1620



ctggcgatgg tgtcgtgtgc ctgtagtcct agttacttaa gaggctgagt tgggaggatc     1680



agttgaaccc agtggttctg ggttgcagtg agctgtggtc acaccactga actccagcct     1740



gtgcgactga gtgagaccct gtgtctaaaa aaataaaaat ataatgaatg tgatttatgt     1800



agataaattg ataatatagt aaataggtaa atgccttaaa aagcattttt aaagaatttg     1860



taaattctaa aacaataaaa atttggtata catcaaaaaa aaaaaa                    1906





<210>  181

<211>  194

<212>  PRT

<213>  Homo sapiens



<400>  181



Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 

1               5                   10                  15      





Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 

            20                  25                  30          





Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 

        35                  40                  45              





Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 

    50                  55                  60                  





Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 

65                  70                  75                  80  





Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 

                85                  90                  95      





Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 

            100                 105                 110         





Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 

        115                 120                 125             





Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 

    130                 135                 140                 





Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 

145                 150                 155                 160 





Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 

                165                 170                 175     





Thr Asp His Ile Val Gln Val Lys Val Asn Lys Tyr Gly Asp Thr Trp 

            180                 185                 190         





Asp Glu 

        





<210>  182

<211>  1951

<212>  DNA

<213>  Homo sapiens



<400>  182

attcctaggc tgctggctct cagacccgca gtgaggtctg acgtcatttc ctgccgtaag       60



tatacagtgc ctccgggtcg cggtcatttt gagcccctgt ctggatgact tcttgcggct      120



gttctacccc tccccctccc cgcggtacct tgcacttttc tccctccctg ccccctctcg      180



agtccaccct ccgggccttc tgcccctgat cgcttggttt tccttgcagt cgcctgctgc      240



tgtcgtcggg aggaaagatg aatgggaggg ctgattttcg agagccgaat gcagaggttc      300



caagaccaat tccccacata gggcctgatt acattccaac agaggaagaa aggagagtct      360



tcgcagaatg caatgatgaa agcttctggt tcagatctgt gcctttggct gcaacaagta      420



tgttgattac tcaaggatta attagtaaag gaatactttc aagtcatccc aaatatggtt      480



ccatccctaa acttatactt gcttgtatca tgggatactt tgctggaaaa ctttcttatg      540



tgaaaacttg ccaagagaaa ttcaagaaac ttgaaaattc cccccttgga gaagctttac      600



gatcaggaca agcacgacga tcttcaccac ctgggcacta ttatcaaaag tcaaaatatg      660



actcaagtgt gagtggtcaa tcatcttttg tgacatcccc agcagcagac aacatagaaa      720



tgcttcctca ttatgagcca attccattca gttcttctat gaatgaatct gctcccactg      780



gtattactga tcatattgtc caaggtagaa acttctcttg aaatgaattt caacatttta      840



tggtccaact caaagtaaac aagtatggag atacttggga tgagtgaaaa attacatcat      900



tggacatgaa ggagtttcaa catccagctt catctaggtg gtcatgatta cctgcatgct      960



ttgagctcag cagcagtctt cataaacaca tttaaaacaa gatcctgggt ttttgtggtt     1020



tgacttctat ggtgttttaa aaaaacacag atttttagtg ttaatattgt gtaaatgtac     1080



tcaccttagg gattcatttg aatgatggta ttataccatg attgtataca gtttgtgaaa     1140



ttgttgcaag ggcaaagata actcttaaaa aaccgtcgag attacaatgc tctagaatca     1200



gcatataaga aaataaatga tatctgcatg ttgaattggg gtggatgggg ggagcaagca     1260



taatttttaa gtgtgaagct ttgcatcaag aaattattaa aaagcttttt ttctccagta     1320



ttttctgtat tatcttaatg tttatggcaa ataaaatgta aaggaacatg caacagccct     1380



catcttcctt gattttatgg ttttattgtt tgtaatttat tgatttattt ttaagctagt     1440



tataatcatg taggtatagg aaataaagtc atctataata tttctataat atggctataa     1500



tatggctata aatctataat atggctggag gcagtgggca gtggttcatg cctgtaatcc     1560



cagcactttg ggaggccgaa gtgggaggat tgcatgagtc caggagtttg agaccagcct     1620



gggcaacaaa gcgagaccct gtctttacaa aaaaataaaa attagctggc gatggtgtcg     1680



tgtgcctgta gtcctagtta cttaagaggc tgagttggga ggatcagttg aacccagtgg     1740



ttctgggttg cagtgagctg tggtcacacc actgaactcc agcctgtgcg actgagtgag     1800



accctgtgtc taaaaaaata aaaatataat gaatgtgatt tatgtagata aattgataat     1860



atagtaaata ggtaaatgcc ttaaaaagca tttttaaaga atttgtaaat tctaaaacaa     1920



taaaaatttg gtatacatca aaaaaaaaaa a                                    1951





<210>  183

<211>  187

<212>  PRT

<213>  Homo sapiens



<400>  183



Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 

1               5                   10                  15      





Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 

            20                  25                  30          





Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 

        35                  40                  45              





Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 

    50                  55                  60                  





Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 

65                  70                  75                  80  





Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 

                85                  90                  95      





Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 

            100                 105                 110         





Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 

        115                 120                 125             





Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 

    130                 135                 140                 





Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 

145                 150                 155                 160 





Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 

                165                 170                 175     





Thr Asp His Ile Val Gln Gly Arg Asn Phe Ser 

            180                 185         





<210>  184

<211>  1754

<212>  DNA

<213>  Homo sapiens



<400>  184

attcctaggc tgctggctct cagacccgca gtgaggtctg acgtcatttc ctgccgaaag       60



atgaatggga gggctgattt tcgagagccg aatgcagagg ttccaagacc aattccccac      120



atagggcctg attacattcc aacagaggaa gaaaggagag tcttcgcaga atgcaatgat      180



gaaagcttct ggttcagatc tgtgcctttg gctgcaacaa gtatgttgat tactcaagga      240



ttaattagta aaggaatact ttcaagtcat cccaaatatg gttccatccc taaacttata      300



cttgcttgta tcatgggata ctttgctgga aaactttctt atgtgaaaac ttgccaagag      360



aaattcaaga aacttgaaaa ttcccccctt ggagaagctt tacgatcagg acaagcacga      420



cgatcttcac cacctgggca ctattatcaa aagtcaaaat atgactcaag tgtgagtggt      480



caatcatctt ttgtgacatc cccagcagca gacaacatag aaatgcttcc tcattatgag      540



ccaattccat tcagttcttc tatgaatgaa tctgctccca ctggtattac tgatcatatt      600



gtccaaggta gaaacttctc ttgaaatgaa tttcaacatt ttatggtcca actcaaagta      660



aacaagtatg gagatacttg ggatgagtga aaaattacat cattggacat gaaggagttt      720



caacatccag cttcatctag gtggtcatga ttacctgcat gctttgagct cagcagcagt      780



cttcataaac acatttaaaa caagatcctg ggtttttgtg gtttgacttc tatggtgttt      840



taaaaaaaca cagattttta gtgttaatat tgtgtaaatg tactcacctt agggattcat      900



ttgaatgatg gtattatacc atgattgtat acagtttgtg aaattgttgc aagggcaaag      960



ataactctta aaaaaccgtc gagattacaa tgctctagaa tcagcatata agaaaataaa     1020



tgatatctgc atgttgaatt ggggtggatg gggggagcaa gcataatttt taagtgtgaa     1080



gctttgcatc aagaaattat taaaaagctt tttttctcca gtattttctg tattatctta     1140



atgtttatgg caaataaaat gtaaaggaac atgcaacagc cctcatcttc cttgatttta     1200



tggttttatt gtttgtaatt tattgattta tttttaagct agttataatc atgtaggtat     1260



aggaaataaa gtcatctata atatttctat aatatggcta taatatggct ataaatctat     1320



aatatggctg gaggcagtgg gcagtggttc atgcctgtaa tcccagcact ttgggaggcc     1380



gaagtgggag gattgcatga gtccaggagt ttgagaccag cctgggcaac aaagcgagac     1440



cctgtcttta caaaaaaata aaaattagct ggcgatggtg tcgtgtgcct gtagtcctag     1500



ttacttaaga ggctgagttg ggaggatcag ttgaacccag tggttctggg ttgcagtgag     1560



ctgtggtcac accactgaac tccagcctgt gcgactgagt gagaccctgt gtctaaaaaa     1620



ataaaaatat aatgaatgtg atttatgtag ataaattgat aatatagtaa ataggtaaat     1680



gccttaaaaa gcatttttaa agaatttgta aattctaaaa caataaaaat ttggtataca     1740



tcaaaaaaaa aaaa                                                       1754





<210>  185

<211>  187

<212>  PRT

<213>  Homo sapiens



<400>  185



Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 

1               5                   10                  15      





Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 

            20                  25                  30          





Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 

        35                  40                  45              





Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 

    50                  55                  60                  





Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 

65                  70                  75                  80  





Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 

                85                  90                  95      





Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 

            100                 105                 110         





Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 

        115                 120                 125             





Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 

    130                 135                 140                 





Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 

145                 150                 155                 160 





Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 

                165                 170                 175     





Thr Asp His Ile Val Gln Gly Arg Asn Phe Ser 

            180                 185         





<210>  186

<211>  2059

<212>  DNA

<213>  Homo sapiens



<400>  186

attcctaggc tgctggctct cagacccgca gtgaggtctg acgtcatttc ctgccgtaag       60



tatacagtgc ctccgggtcg cggtcatttt gagcccctgt ctggatgact tcttgcggct      120



gttctacccc tccccctccc cgcggtacct tgcacttttc tccctccctg ccccctctcg      180



agtccaccct ccgggccttc tgcccctgat cgcttggttt tccttgcagt cgcctgctgc      240



tgtcgtcggg aggaaagatg aatgggaggg ctgattttcg agagccgaat gcagaggttc      300



caagaccaat tccccacata gggcctgatt acattccaac agaggaagaa aggagagtct      360



tcgcagaatg caatgatgaa agcttctggt tcagatctgt gcctttggct gcaacaagta      420



tgttgattac tcaaggatta attagtaaag gaatactttc aagtcatccc aaatatggtt      480



ccatccctaa acttatactt gcttgtatca tgggatactt tgctggaaaa ctttcttatg      540



tgaaaacttg ccaagagaaa ttcaagaaac ttgaaaattc cccccttgga gaagctttac      600



gatcaggaca agcacgacga tcttcaccac ctgggcacta ttatcaaaag tcaaaatatg      660



actcaagtgt gagtggtcaa tcatcttttg tgacatcccc agcagcagac aacatagaaa      720



tgcttcctca ttatgagcca attccattca gttcttctat gaatgaatct gctcccactg      780



gtattactga tcatattgtc caaggacctg atcccaacct tgaagaaagt cctaaaagaa      840



aaaatattac atatgaggaa ttaaggaata agaacagaga gtcatatgaa gtatctttaa      900



cacaaaagac tgacccctca gtcaggccta tgcatgaaag agtgccaaaa aaagaagtca      960



aagtaaacaa gtatggagat acttgggatg agtgaaaaat tacatcattg gacatgaagg     1020



agtttcaaca tccagcttca tctaggtggt catgattacc tgcatgcttt gagctcagca     1080



gcagtcttca taaacacatt taaaacaaga tcctgggttt ttgtggtttg acttctatgg     1140



tgttttaaaa aaacacagat ttttagtgtt aatattgtgt aaatgtactc accttaggga     1200



ttcatttgaa tgatggtatt ataccatgat tgtatacagt ttgtgaaatt gttgcaaggg     1260



caaagataac tcttaaaaaa ccgtcgagat tacaatgctc tagaatcagc atataagaaa     1320



ataaatgata tctgcatgtt gaattggggt ggatgggggg agcaagcata atttttaagt     1380



gtgaagcttt gcatcaagaa attattaaaa agcttttttt ctccagtatt ttctgtatta     1440



tcttaatgtt tatggcaaat aaaatgtaaa ggaacatgca acagccctca tcttccttga     1500



ttttatggtt ttattgtttg taatttattg atttattttt aagctagtta taatcatgta     1560



ggtataggaa ataaagtcat ctataatatt tctataatat ggctataata tggctataaa     1620



tctataatat ggctggaggc agtgggcagt ggttcatgcc tgtaatccca gcactttggg     1680



aggccgaagt gggaggattg catgagtcca ggagtttgag accagcctgg gcaacaaagc     1740



gagaccctgt ctttacaaaa aaataaaaat tagctggcga tggtgtcgtg tgcctgtagt     1800



cctagttact taagaggctg agttgggagg atcagttgaa cccagtggtt ctgggttgca     1860



gtgagctgtg gtcacaccac tgaactccag cctgtgcgac tgagtgagac cctgtgtcta     1920



aaaaaataaa aatataatga atgtgattta tgtagataaa ttgataatat agtaaatagg     1980



taaatgcctt aaaaagcatt tttaaagaat ttgtaaattc taaaacaata aaaatttggt     2040



atacatcaaa aaaaaaaaa                                                  2059





<210>  187

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  187



Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 

1               5                   10                  15      





Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 

            20                  25                  30          





Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 

        35                  40                  45              





Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 

    50                  55                  60                  





Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 

65                  70                  75                  80  





Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 

                85                  90                  95      





Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 

            100                 105                 110         





Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 

        115                 120                 125             





Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 

    130                 135                 140                 





Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 

145                 150                 155                 160 





Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 

                165                 170                 175     





Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 

            180                 185                 190         





Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 

        195                 200                 205             





Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 

    210                 215                 220                 





Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 

225                 230                 235                 240 





Asp Thr Trp Asp Glu 

                245 





<210>  188

<211>  2818

<212>  DNA

<213>  Homo sapiens



<400>  188

ggggcatgcc gggagtggtt gtgtacggtc cgcagcggca ggtgaagtct agcagaggac       60



gcggccaggc gattcggtga agcgattcct gcaggcgttg gttcccctct ttgacctggt      120



aaatgcaggc ttttatgcga gaggatttga atttgttgaa atgagcagtc gtaaatcaaa      180



gagtaacagc ttaattcaca cagagtgcct ttcacaggta caaagaattt tacgtgaaag      240



attttgtcgt cagagtccac atagtaacct atttggagtg caagtacaat acaaacactt      300



aagtgagctg ctgaaaagaa ctgctctcca tggagagagt aactctgtcc ttattatcgg      360



accccgagga tcaggaaaaa ctatgttaat aaatcatgct ttgaaagaac tcatggaaat      420



agaagaagtg agtgaaaatg tattacaagt tcacttaaat ggactgctgc agatcaatga      480



caaaatcgcc ctaaaggaaa tcacaaggca gttaaatctg gaaaatgtag ttggagataa      540



agtttttgga agctttgctg aaaacctttc atttcttctg gaagctttaa aaaaaggtga      600



ccgaactagc agttgcccag tgatcttcat attagatgaa tttgatcttt ttgctcatca      660



taaaaaccaa acacttctct ataatctttt tgacatttct cagtctgcac agaccccaat      720



agcagttatt ggtcttacat gtagattgga tattttggaa ctcttagaaa aaagagtgaa      780



gtcaagattt tctcaccggc agatacactt aatgaattca tttggttttc cacagtatgt      840



taaaatattt aaagaacagt tatctctacc tgcagagttt ccagacaagg tttttgctga      900



gaagtggaat gaaaatgttc agtatctctc agaagataga agtgtgcaag aagtactaca      960



gaagcatttc aatatcagca aaaacctgcg gtcattacac atgctattga tgcttgcttt     1020



aaatcgagta acagcatcgc acccatttat gactgccgta gatctaatgg aagcaagcca     1080



actgtgtagc atggactcga aagcaaatat tgtacatggt ctatcagtct tggaaatctg     1140



tcttataata gcaatgaaac atttaaatga catctatgag gaagagccat ttaattttca     1200



aatggtctat aatgagtttc agaagtttgt tcaaaggaaa gcacattccg tttataattt     1260



tgaaaaacct gttgtcatga aggcttttga acacttgcag caattagaat taataaagcc     1320



catggaaaga acttcaggaa attcacagag agagtaccag ctgatgaaac tgcttttgga     1380



taatactcaa attatgaatg ctctgcagaa atatcccaac tgtcctacag atgtgaggca     1440



gtgggcaaca tcctcactaa gctggttatg aatataacca gtgacttcaa ctttggcatt     1500



tcattcatac ttctgtagag aacggaaaac tattgtccat taacatgata tgctaaacat     1560



tctataaaca ttcttgtatt tatgtgagac ttgcccatct actgtcttgg ctgtgtcttg     1620



ccttttaatc atgaacagtt acatgattta taatttcact gattgagatt actttgtaag     1680



tagctgttca gaagaataaa atatgactgt tttagggact agaccatgtg cttttttaac     1740



acttatatat ataatggtct atttgaagag ctcacttcaa cctaacagct agatgtcttt     1800



acaaacctta aaccaaagga gtaaaaaaaa caatggtaag cactgaagta taataagtaa     1860



cctttggtac agcaggtttg ctgcagtgtt tttttctgtc cacatgcaaa ttttggattc     1920



tatcccagac ccaggttttc tagttcagaa gactaaccag cttagtcaga agatggttcc     1980



atggaagaaa aaggccaagg agtttgaaga tttttcttct agacatctca aaatgtggta     2040



ctcataccat ccacatcaga atcccttgta ggattttcta aaattacaga ttgttgagcc     2100



taccataggt caaaaggact ggaattttcc ttcttaacaa gtatagtcat ggcaccacgt     2160



aacattttgg tcaatgacat tgtataaagg gtggtctcat aagattatac catattttta     2220



ctgtaccttt tctatgtcta aatatacaaa tgttttacca ttgtgttaca gttgcctaca     2280



gtatgattac agtaacattc tgtacagtgc tatagctgaa gagtaatagg ctaggctatc     2340



tgtatagcct aagtgtgtaa caggctatat acatatcatc agggtctgtg taagtatact     2400



ctgtgatgtt catacagtga tgaaatcacc caaagacaca tttctcagaa cgtagcccca     2460



tcatgaagtg acgtgactac cagagatttc tggaaaagca ctcccaaaag taatgagatg     2520



tgtatggcaa tgttaactga acctgtttgt attaaaaagt aaatccctat gaggaatgtg     2580



gaaatgtccg tcaaagcatt gtcttttaag taagttccaa gatccatgaa ttaacagagg     2640



catatattta aaatgaaatt taatgagcac ttagtgactt catttgttca agaatatttg     2700



atttcctatt gtgtgcatgg gaggtttaca aaagacagac tgtccctatg cttgtgcagc     2760



ttacaatcta tttaactatt agaggccctg tgagatgtag gcagttattt acagatga       2818





<210>  189

<211>  436

<212>  PRT

<213>  Homo sapiens



<400>  189



Met Ser Ser Arg Lys Ser Lys Ser Asn Ser Leu Ile His Thr Glu Cys 

1               5                   10                  15      





Leu Ser Gln Val Gln Arg Ile Leu Arg Glu Arg Phe Cys Arg Gln Ser 

            20                  25                  30          





Pro His Ser Asn Leu Phe Gly Val Gln Val Gln Tyr Lys His Leu Ser 

        35                  40                  45              





Glu Leu Leu Lys Arg Thr Ala Leu His Gly Glu Ser Asn Ser Val Leu 

    50                  55                  60                  





Ile Ile Gly Pro Arg Gly Ser Gly Lys Thr Met Leu Ile Asn His Ala 

65                  70                  75                  80  





Leu Lys Glu Leu Met Glu Ile Glu Glu Val Ser Glu Asn Val Leu Gln 

                85                  90                  95      





Val His Leu Asn Gly Leu Leu Gln Ile Asn Asp Lys Ile Ala Leu Lys 

            100                 105                 110         





Glu Ile Thr Arg Gln Leu Asn Leu Glu Asn Val Val Gly Asp Lys Val 

        115                 120                 125             





Phe Gly Ser Phe Ala Glu Asn Leu Ser Phe Leu Leu Glu Ala Leu Lys 

    130                 135                 140                 





Lys Gly Asp Arg Thr Ser Ser Cys Pro Val Ile Phe Ile Leu Asp Glu 

145                 150                 155                 160 





Phe Asp Leu Phe Ala His His Lys Asn Gln Thr Leu Leu Tyr Asn Leu 

                165                 170                 175     





Phe Asp Ile Ser Gln Ser Ala Gln Thr Pro Ile Ala Val Ile Gly Leu 

            180                 185                 190         





Thr Cys Arg Leu Asp Ile Leu Glu Leu Leu Glu Lys Arg Val Lys Ser 

        195                 200                 205             





Arg Phe Ser His Arg Gln Ile His Leu Met Asn Ser Phe Gly Phe Pro 

    210                 215                 220                 





Gln Tyr Val Lys Ile Phe Lys Glu Gln Leu Ser Leu Pro Ala Glu Phe 

225                 230                 235                 240 





Pro Asp Lys Val Phe Ala Glu Lys Trp Asn Glu Asn Val Gln Tyr Leu 

                245                 250                 255     





Ser Glu Asp Arg Ser Val Gln Glu Val Leu Gln Lys His Phe Asn Ile 

            260                 265                 270         





Ser Lys Asn Leu Arg Ser Leu His Met Leu Leu Met Leu Ala Leu Asn 

        275                 280                 285             





Arg Val Thr Ala Ser His Pro Phe Met Thr Ala Val Asp Leu Met Glu 

    290                 295                 300                 





Ala Ser Gln Leu Cys Ser Met Asp Ser Lys Ala Asn Ile Val His Gly 

305                 310                 315                 320 





Leu Ser Val Leu Glu Ile Cys Leu Ile Ile Ala Met Lys His Leu Asn 

                325                 330                 335     





Asp Ile Tyr Glu Glu Glu Pro Phe Asn Phe Gln Met Val Tyr Asn Glu 

            340                 345                 350         





Phe Gln Lys Phe Val Gln Arg Lys Ala His Ser Val Tyr Asn Phe Glu 

        355                 360                 365             





Lys Pro Val Val Met Lys Ala Phe Glu His Leu Gln Gln Leu Glu Leu 

    370                 375                 380                 





Ile Lys Pro Met Glu Arg Thr Ser Gly Asn Ser Gln Arg Glu Tyr Gln 

385                 390                 395                 400 





Leu Met Lys Leu Leu Leu Asp Asn Thr Gln Ile Met Asn Ala Leu Gln 

                405                 410                 415     





Lys Tyr Pro Asn Cys Pro Thr Asp Val Arg Gln Trp Ala Thr Ser Ser 

            420                 425                 430         





Leu Ser Trp Leu 

        435     





<210>  190

<211>  2793

<212>  DNA

<213>  Homo sapiens



<400>  190

ggggcatgcc gggagtggtt gtgtacggtc cgcagcggca ggtgaagtct agcagaggac       60



gcggccaggc gattcggtga agcgattcct gcaggcgttg gttcccctct ttgacctgga      120



tttgaatttg ttgaaatgag cagtcgtaaa tcaaagagta acagcttaat tcacacagag      180



tgcctttcac aggtacaaag aattttacgt gaaagatttt gtcgtcagag tccacatagt      240



aacctatttg gagtgcaagt acaatacaaa cacttaagtg agctgctgaa aagaactgct      300



ctccatggag agagtaactc tgtccttatt atcggacccc gaggatcagg aaaaactatg      360



ttaataaatc atgctttgaa agaactcatg gaaatagaag aagtgagtga aaatgtatta      420



caagttcact taaatggact gctgcagatc aatgacaaaa tcgccctaaa ggaaatcaca      480



aggcagttaa atctggaaaa tgtagttgga gataaagttt ttggaagctt tgctgaaaac      540



ctttcatttc ttctggaagc tttaaaaaaa ggtgaccgaa ctagcagttg cccagtgatc      600



ttcatattag atgaatttga tctttttgct catcataaaa accaaacact tctctataat      660



ctttttgaca tttctcagtc tgcacagacc ccaatagcag ttattggtct tacatgtaga      720



ttggatattt tggaactctt agaaaaaaga gtgaagtcaa gattttctca ccggcagata      780



cacttaatga attcatttgg ttttccacag tatgttaaaa tatttaaaga acagttatct      840



ctacctgcag agtttccaga caaggttttt gctgagaagt ggaatgaaaa tgttcagtat      900



ctctcagaag atagaagtgt gcaagaagta ctacagaagc atttcaatat cagcaaaaac      960



ctgcggtcat tacacatgct attgatgctt gctttaaatc gagtaacagc atcgcaccca     1020



tttatgactg ccgtagatct aatggaagca agccaactgt gtagcatgga ctcgaaagca     1080



aatattgtac atggtctatc agtcttggaa atctgtctta taatagcaat gaaacattta     1140



aatgacatct atgaggaaga gccatttaat tttcaaatgg tctataatga gtttcagaag     1200



tttgttcaaa ggaaagcaca ttccgtttat aattttgaaa aacctgttgt catgaaggct     1260



tttgaacact tgcagcaatt agaattaata aagcccatgg aaagaacttc aggaaattca     1320



cagagagagt accagctgat gaaactgctt ttggataata ctcaaattat gaatgctctg     1380



cagaaatatc ccaactgtcc tacagatgtg aggcagtggg caacatcctc actaagctgg     1440



ttatgaatat aaccagtgac ttcaactttg gcatttcatt catacttctg tagagaacgg     1500



aaaactattg tccattaaca tgatatgcta aacattctat aaacattctt gtatttatgt     1560



gagacttgcc catctactgt cttggctgtg tcttgccttt taatcatgaa cagttacatg     1620



atttataatt tcactgattg agattacttt gtaagtagct gttcagaaga ataaaatatg     1680



actgttttag ggactagacc atgtgctttt ttaacactta tatatataat ggtctatttg     1740



aagagctcac ttcaacctaa cagctagatg tctttacaaa ccttaaacca aaggagtaaa     1800



aaaaacaatg gtaagcactg aagtataata agtaaccttt ggtacagcag gtttgctgca     1860



gtgttttttt ctgtccacat gcaaattttg gattctatcc cagacccagg ttttctagtt     1920



cagaagacta accagcttag tcagaagatg gttccatgga agaaaaaggc caaggagttt     1980



gaagattttt cttctagaca tctcaaaatg tggtactcat accatccaca tcagaatccc     2040



ttgtaggatt ttctaaaatt acagattgtt gagcctacca taggtcaaaa ggactggaat     2100



tttccttctt aacaagtata gtcatggcac cacgtaacat tttggtcaat gacattgtat     2160



aaagggtggt ctcataagat tataccatat ttttactgta ccttttctat gtctaaatat     2220



acaaatgttt taccattgtg ttacagttgc ctacagtatg attacagtaa cattctgtac     2280



agtgctatag ctgaagagta ataggctagg ctatctgtat agcctaagtg tgtaacaggc     2340



tatatacata tcatcagggt ctgtgtaagt atactctgtg atgttcatac agtgatgaaa     2400



tcacccaaag acacatttct cagaacgtag ccccatcatg aagtgacgtg actaccagag     2460



atttctggaa aagcactccc aaaagtaatg agatgtgtat ggcaatgtta actgaacctg     2520



tttgtattaa aaagtaaatc cctatgagga atgtggaaat gtccgtcaaa gcattgtctt     2580



ttaagtaagt tccaagatcc atgaattaac agaggcatat atttaaaatg aaatttaatg     2640



agcacttagt gacttcattt gttcaagaat atttgatttc ctattgtgtg catgggaggt     2700



ttacaaaaga cagactgtcc ctatgcttgt gcagcttaca atctatttaa ctattagagg     2760



ccctgtgaga tgtaggcagt tatttacaga tga                                  2793





<210>  191

<211>  436

<212>  PRT

<213>  Homo sapiens



<400>  191



Met Ser Ser Arg Lys Ser Lys Ser Asn Ser Leu Ile His Thr Glu Cys 

1               5                   10                  15      





Leu Ser Gln Val Gln Arg Ile Leu Arg Glu Arg Phe Cys Arg Gln Ser 

            20                  25                  30          





Pro His Ser Asn Leu Phe Gly Val Gln Val Gln Tyr Lys His Leu Ser 

        35                  40                  45              





Glu Leu Leu Lys Arg Thr Ala Leu His Gly Glu Ser Asn Ser Val Leu 

    50                  55                  60                  





Ile Ile Gly Pro Arg Gly Ser Gly Lys Thr Met Leu Ile Asn His Ala 

65                  70                  75                  80  





Leu Lys Glu Leu Met Glu Ile Glu Glu Val Ser Glu Asn Val Leu Gln 

                85                  90                  95      





Val His Leu Asn Gly Leu Leu Gln Ile Asn Asp Lys Ile Ala Leu Lys 

            100                 105                 110         





Glu Ile Thr Arg Gln Leu Asn Leu Glu Asn Val Val Gly Asp Lys Val 

        115                 120                 125             





Phe Gly Ser Phe Ala Glu Asn Leu Ser Phe Leu Leu Glu Ala Leu Lys 

    130                 135                 140                 





Lys Gly Asp Arg Thr Ser Ser Cys Pro Val Ile Phe Ile Leu Asp Glu 

145                 150                 155                 160 





Phe Asp Leu Phe Ala His His Lys Asn Gln Thr Leu Leu Tyr Asn Leu 

                165                 170                 175     





Phe Asp Ile Ser Gln Ser Ala Gln Thr Pro Ile Ala Val Ile Gly Leu 

            180                 185                 190         





Thr Cys Arg Leu Asp Ile Leu Glu Leu Leu Glu Lys Arg Val Lys Ser 

        195                 200                 205             





Arg Phe Ser His Arg Gln Ile His Leu Met Asn Ser Phe Gly Phe Pro 

    210                 215                 220                 





Gln Tyr Val Lys Ile Phe Lys Glu Gln Leu Ser Leu Pro Ala Glu Phe 

225                 230                 235                 240 





Pro Asp Lys Val Phe Ala Glu Lys Trp Asn Glu Asn Val Gln Tyr Leu 

                245                 250                 255     





Ser Glu Asp Arg Ser Val Gln Glu Val Leu Gln Lys His Phe Asn Ile 

            260                 265                 270         





Ser Lys Asn Leu Arg Ser Leu His Met Leu Leu Met Leu Ala Leu Asn 

        275                 280                 285             





Arg Val Thr Ala Ser His Pro Phe Met Thr Ala Val Asp Leu Met Glu 

    290                 295                 300                 





Ala Ser Gln Leu Cys Ser Met Asp Ser Lys Ala Asn Ile Val His Gly 

305                 310                 315                 320 





Leu Ser Val Leu Glu Ile Cys Leu Ile Ile Ala Met Lys His Leu Asn 

                325                 330                 335     





Asp Ile Tyr Glu Glu Glu Pro Phe Asn Phe Gln Met Val Tyr Asn Glu 

            340                 345                 350         





Phe Gln Lys Phe Val Gln Arg Lys Ala His Ser Val Tyr Asn Phe Glu 

        355                 360                 365             





Lys Pro Val Val Met Lys Ala Phe Glu His Leu Gln Gln Leu Glu Leu 

    370                 375                 380                 





Ile Lys Pro Met Glu Arg Thr Ser Gly Asn Ser Gln Arg Glu Tyr Gln 

385                 390                 395                 400 





Leu Met Lys Leu Leu Leu Asp Asn Thr Gln Ile Met Asn Ala Leu Gln 

                405                 410                 415     





Lys Tyr Pro Asn Cys Pro Thr Asp Val Arg Gln Trp Ala Thr Ser Ser 

            420                 425                 430         





Leu Ser Trp Leu 

        435     





<210>  192

<211>  2795

<212>  DNA

<213>  Homo sapiens



<400>  192

gtggctgctc ctgggtgtag tgagatgtct ccagccaggg ccaagcagca gcagtagcag       60



cagcagcagt agcagcagca gcagcaacag cagcagcagc agcaacagca gcagcaaagg      120



gatttgaatt tgttgaaatg agcagtcgta aatcaaagag taacagctta attcacacag      180



agtgcctttc acaggtacaa agaattttac gtgaaagatt ttgtcgtcag agtccacata      240



gtaacctatt tggagtgcaa gtacaataca aacacttaag tgagctgctg aaaagaactg      300



ctctccatgg agagagtaac tctgtcctta ttatcggacc ccgaggatca ggaaaaacta      360



tgttaataaa tcatgctttg aaagaactca tggaaataga agaagtgagt gaaaatgtat      420



tacaagttca cttaaatgga ctgctgcaga tcaatgacaa aatcgcccta aaggaaatca      480



caaggcagtt aaatctggaa aatgtagttg gagataaagt ttttggaagc tttgctgaaa      540



acctttcatt tcttctggaa gctttaaaaa aaggtgaccg aactagcagt tgcccagtga      600



tcttcatatt agatgaattt gatctttttg ctcatcataa aaaccaaaca cttctctata      660



atctttttga catttctcag tctgcacaga ccccaatagc agttattggt cttacatgta      720



gattggatat tttggaactc ttagaaaaaa gagtgaagtc aagattttct caccggcaga      780



tacacttaat gaattcattt ggttttccac agtatgttaa aatatttaaa gaacagttat      840



ctctacctgc agagtttcca gacaaggttt ttgctgagaa gtggaatgaa aatgttcagt      900



atctctcaga agatagaagt gtgcaagaag tactacagaa gcatttcaat atcagcaaaa      960



acctgcggtc attacacatg ctattgatgc ttgctttaaa tcgagtaaca gcatcgcacc     1020



catttatgac tgccgtagat ctaatggaag caagccaact gtgtagcatg gactcgaaag     1080



caaatattgt acatggtcta tcagtcttgg aaatctgtct tataatagca atgaaacatt     1140



taaatgacat ctatgaggaa gagccattta attttcaaat ggtctataat gagtttcaga     1200



agtttgttca aaggaaagca cattccgttt ataattttga aaaacctgtt gtcatgaagg     1260



cttttgaaca cttgcagcaa ttagaattaa taaagcccat ggaaagaact tcaggaaatt     1320



cacagagaga gtaccagctg atgaaactgc ttttggataa tactcaaatt atgaatgctc     1380



tgcagaaata tcccaactgt cctacagatg tgaggcagtg ggcaacatcc tcactaagct     1440



ggttatgaat ataaccagtg acttcaactt tggcatttca ttcatacttc tgtagagaac     1500



ggaaaactat tgtccattaa catgatatgc taaacattct ataaacattc ttgtatttat     1560



gtgagacttg cccatctact gtcttggctg tgtcttgcct tttaatcatg aacagttaca     1620



tgatttataa tttcactgat tgagattact ttgtaagtag ctgttcagaa gaataaaata     1680



tgactgtttt agggactaga ccatgtgctt ttttaacact tatatatata atggtctatt     1740



tgaagagctc acttcaacct aacagctaga tgtctttaca aaccttaaac caaaggagta     1800



aaaaaaacaa tggtaagcac tgaagtataa taagtaacct ttggtacagc aggtttgctg     1860



cagtgttttt ttctgtccac atgcaaattt tggattctat cccagaccca ggttttctag     1920



ttcagaagac taaccagctt agtcagaaga tggttccatg gaagaaaaag gccaaggagt     1980



ttgaagattt ttcttctaga catctcaaaa tgtggtactc ataccatcca catcagaatc     2040



ccttgtagga ttttctaaaa ttacagattg ttgagcctac cataggtcaa aaggactgga     2100



attttccttc ttaacaagta tagtcatggc accacgtaac attttggtca atgacattgt     2160



ataaagggtg gtctcataag attataccat atttttactg taccttttct atgtctaaat     2220



atacaaatgt tttaccattg tgttacagtt gcctacagta tgattacagt aacattctgt     2280



acagtgctat agctgaagag taataggcta ggctatctgt atagcctaag tgtgtaacag     2340



gctatataca tatcatcagg gtctgtgtaa gtatactctg tgatgttcat acagtgatga     2400



aatcacccaa agacacattt ctcagaacgt agccccatca tgaagtgacg tgactaccag     2460



agatttctgg aaaagcactc ccaaaagtaa tgagatgtgt atggcaatgt taactgaacc     2520



tgtttgtatt aaaaagtaaa tccctatgag gaatgtggaa atgtccgtca aagcattgtc     2580



ttttaagtaa gttccaagat ccatgaatta acagaggcat atatttaaaa tgaaatttaa     2640



tgagcactta gtgacttcat ttgttcaaga atatttgatt tcctattgtg tgcatgggag     2700



gtttacaaaa gacagactgt ccctatgctt gtgcagctta caatctattt aactattaga     2760



ggccctgtga gatgtaggca gttatttaca gatga                                2795





<210>  193

<211>  436

<212>  PRT

<213>  Homo sapiens



<400>  193



Met Ser Ser Arg Lys Ser Lys Ser Asn Ser Leu Ile His Thr Glu Cys 

1               5                   10                  15      





Leu Ser Gln Val Gln Arg Ile Leu Arg Glu Arg Phe Cys Arg Gln Ser 

            20                  25                  30          





Pro His Ser Asn Leu Phe Gly Val Gln Val Gln Tyr Lys His Leu Ser 

        35                  40                  45              





Glu Leu Leu Lys Arg Thr Ala Leu His Gly Glu Ser Asn Ser Val Leu 

    50                  55                  60                  





Ile Ile Gly Pro Arg Gly Ser Gly Lys Thr Met Leu Ile Asn His Ala 

65                  70                  75                  80  





Leu Lys Glu Leu Met Glu Ile Glu Glu Val Ser Glu Asn Val Leu Gln 

                85                  90                  95      





Val His Leu Asn Gly Leu Leu Gln Ile Asn Asp Lys Ile Ala Leu Lys 

            100                 105                 110         





Glu Ile Thr Arg Gln Leu Asn Leu Glu Asn Val Val Gly Asp Lys Val 

        115                 120                 125             





Phe Gly Ser Phe Ala Glu Asn Leu Ser Phe Leu Leu Glu Ala Leu Lys 

    130                 135                 140                 





Lys Gly Asp Arg Thr Ser Ser Cys Pro Val Ile Phe Ile Leu Asp Glu 

145                 150                 155                 160 





Phe Asp Leu Phe Ala His His Lys Asn Gln Thr Leu Leu Tyr Asn Leu 

                165                 170                 175     





Phe Asp Ile Ser Gln Ser Ala Gln Thr Pro Ile Ala Val Ile Gly Leu 

            180                 185                 190         





Thr Cys Arg Leu Asp Ile Leu Glu Leu Leu Glu Lys Arg Val Lys Ser 

        195                 200                 205             





Arg Phe Ser His Arg Gln Ile His Leu Met Asn Ser Phe Gly Phe Pro 

    210                 215                 220                 





Gln Tyr Val Lys Ile Phe Lys Glu Gln Leu Ser Leu Pro Ala Glu Phe 

225                 230                 235                 240 





Pro Asp Lys Val Phe Ala Glu Lys Trp Asn Glu Asn Val Gln Tyr Leu 

                245                 250                 255     





Ser Glu Asp Arg Ser Val Gln Glu Val Leu Gln Lys His Phe Asn Ile 

            260                 265                 270         





Ser Lys Asn Leu Arg Ser Leu His Met Leu Leu Met Leu Ala Leu Asn 

        275                 280                 285             





Arg Val Thr Ala Ser His Pro Phe Met Thr Ala Val Asp Leu Met Glu 

    290                 295                 300                 





Ala Ser Gln Leu Cys Ser Met Asp Ser Lys Ala Asn Ile Val His Gly 

305                 310                 315                 320 





Leu Ser Val Leu Glu Ile Cys Leu Ile Ile Ala Met Lys His Leu Asn 

                325                 330                 335     





Asp Ile Tyr Glu Glu Glu Pro Phe Asn Phe Gln Met Val Tyr Asn Glu 

            340                 345                 350         





Phe Gln Lys Phe Val Gln Arg Lys Ala His Ser Val Tyr Asn Phe Glu 

        355                 360                 365             





Lys Pro Val Val Met Lys Ala Phe Glu His Leu Gln Gln Leu Glu Leu 

    370                 375                 380                 





Ile Lys Pro Met Glu Arg Thr Ser Gly Asn Ser Gln Arg Glu Tyr Gln 

385                 390                 395                 400 





Leu Met Lys Leu Leu Leu Asp Asn Thr Gln Ile Met Asn Ala Leu Gln 

                405                 410                 415     





Lys Tyr Pro Asn Cys Pro Thr Asp Val Arg Gln Trp Ala Thr Ser Ser 

            420                 425                 430         





Leu Ser Trp Leu 

        435     





<210>  194

<211>  4283

<212>  DNA

<213>  Homo sapiens



<400>  194

ggagggatgt cagccttctc tgaggcggcg ctggagaaga agctgtcgga gttgagcaac       60



tcgcagcaga gcgtgcagac cttgtccctg tggctcattc accaccgtaa acactcgcgg      120



cccatcgtca ccgtgtggga gcgggagctg cggaaagcca aaccaaacag gaagcttact      180



tttctctacc tagccaatga tgtcatacag aacagcaaga ggaaggggcc agagtttaca      240



aaagattttg caccagttat agtggaggct tttaagcatg tttcaagtga aactgatgaa      300



agttgtaaga agcaccttgg aagagtgtta tctatttggg aagaaaggtc tgtttatgaa      360



aatgatgtat tagaacaact taaacaagct ctgtatggtg ataagaagcc taggaagcga      420



acttatgaac agataaaggt ggatgaaaat gaaaactgtt cctctctggg atctccaagt      480



gaaccaccac agactctaga tctcgttaga gcattacaag atctggaaaa tgcagcctca      540



ggtgatgcag cagttcatca gaggatagct tctttacctg ttgaagtcca agaagtatct      600



ctattagata aaataacaga taaagaatct ggagaaaggc tttccaaaat ggtagaggat      660



gcgtgtatgt tgctggcaga ttacaatggc agattggcgg cagaaataga tgatagaaag      720



caactcactc gaatgttagc agattttctt cgttgtcaaa aggaagccct tgcagagaaa      780



gagcataaat tggaagagta caagcgcaag ctagccagag tttccctggt gcgcaaagaa      840



ctcaggtccc ggatccagag cctgccagac ttatctcgat tgcccaatgt cactggcagc      900



cacatgcacc tgccctttgc gggagacatc tacagtgaag attgatggac cagcctcttt      960



ccaggtccca ggactttgca agagatggag acaggttagg tggatagtcc tgtagtgtta     1020



tttttgtata ttgttgagaa agaaacacta acaaaaggaa caacgagtaa tttataaaat     1080



tgtttaaaat gttggtttgt ttactatttt attggtaaat taacatgact taatttgaac     1140



aaagtgatga tttgtgtgta ttaataagct cacaaatagt gattattttc aaaagatctt     1200



tttgtaaatt ttttttttga tccaaggcct tgtgagaaat ctcttgtttg tatttcttca     1260



ggtattttca attgtttttc tttattttct tcagcattta atcactgtat actatgtaat     1320



tcctgaaggg gaagaactaa ttaggagttg attgagactt tattatggta tagttaggac     1380



ttgattgtag aagggactaa atgttccaac ataatcttta cccttctccc caaacaaaat     1440



atcaattctg tgtctctaca tgcctttgat tccttagagg tcggtaattt aacataaaac     1500



agggatgtca ctttgagggg cagatgaaag tctagagaac tgttccttaa tagcattgta     1560



aaagttccat tccaactgcc agtgtagatt ttaaaagtgt taaatagtga ctcccttgat     1620



taaactgttt gtaattattt gagtagatta ataatgaaaa tactttggaa ataatataca     1680



ttttgacatt ctaccaagag gacaactttg gttctggaac tggtttctat ttgtcaaatc     1740



agtttccttt taacataatt aatcccttta acaaaaagcc gtctatggga ttaaaagaca     1800



cgtgaaatga tacttttatt attcccttgc tcatataact ttaaaaataa tacttttagc     1860



tctaatagct caagaacaca atattcgtta atgttcagta aagtagcctg agacattttc     1920



aatgtttcct taaggttttt gaatgactgt atatttggca gttaagcagt gccacactac     1980



agggtagata tggtaaattt tatatttgta tatttacagt tacaaaacaa atgtactttt     2040



accttttatt tctgaccctg tgtgttagag cagttgcatg ctctcctgct gttaaaaaca     2100



cattgttaag ctgtggattt gtactcaata atgacttagg ataaacattt attttcattc     2160



attgctttac atactagaca tttttcttct ctttgtaagt agattcaaat tagatagtca     2220



ataaaacatc ttgaaaatcc cacaagccaa ttatgtctct ctagtctgaa tggcttcatt     2280



gtttctttct cagtattaga aattatagtt acaatgaatt gcatatgaag aaggcagaca     2340



tttattttta atagccaagt agttctgcaa atagttcttt taacaatttg acctctctcc     2400



aaaacagaga cacatataag tagtgctcat ccatgcacta ctaataatac atggcttatt     2460



ccaaagtttt tagtcaactt ttgggacttg gggtgcattt tctcacagaa agaatagtag     2520



ttaggttccc taacactacc gctgatagct cacctgggaa ctgaatccac ctaaccatga     2580



atgtccttca cttgtaacgt ggttcacagg ttactaatca tagatcctga ccagcatttg     2640



taacactgct ctaactagga cacagcatgc agcagccaca ctcacaccct gggatgtctg     2700



tgtacctctg tccctaggtg taggaaatgg aagaaaaaga ttcagccaag tggggaggtg     2760



acagatgcac aattatgaaa cctggttgta catgttatga aagtatacta agtaagttag     2820



tttttattat taatgtgaaa gcaaaaactt gtatgttaac ttattttcaa tatcttgacc     2880



ttatttatga tctgctaaag tggtgattta tccattcaaa atatatattt ttttccattt     2940



aaaactaatt tataaactat gtactcctgg gaagatttga aatcttttag aagtttgttg     3000



aaatattttc accatttcag acagacttct gacttagata ctgattttaa tgccagtatc     3060



tgctctaaat atttatgata aaaatgcatt atttttttaa agagcttgat gagatttgtg     3120



ataagtgata gtactcaaaa acctgaatcc cacccctcga ccaatcctcc acaaacttca     3180



gttgttggtt aacgtattaa ctgaacacag acaatacagt ctgatttaga agtcatcttt     3240



tcagccgtgt gataattaac atggtaagcc ttagcagcaa acattcttcc taaaaggaag     3300



acttcatttt ctcaagaaat gggattagtt gggggtatta taataccaaa ttgtaaatca     3360



tgagcgtttt ctccactgtg cacctgaggc agatcatgca tctttgagtg cagtttggtc     3420



tgacccctca agagaaaagc atggtgccgt agggctgcta tggtttgaat ggatgccatc     3480



actcttttct ccacatacag tgcagagagc tgtctggagt cacaatctga acagattctc     3540



gggcgctcct tctctccttc catcactaca gtaagtaaaa ggaccataga ggggaaccag     3600



gaatctgaga atcagctgtg ctcaatagcc aacctccctg tccagatgca gctattttgg     3660



tatctcctat cacatgcact ctgaatcagg gtttttctat aagaaatctt tcagaatcag     3720



caaaagtggg gatgacccag gcatcttgat ttgcaaaatc acaaaactaa gttgtcagtt     3780



atcactgtag atgagcaact catcttttta aagtatagtt actgaactga ttctgagaaa     3840



tctttagaga gaaaaaactc aacagtacaa attaactaat tgggaaagtt agaatgtcct     3900



ttctgaattt ttcattaaaa aaattacatt atctgaaata acataaagct actaaactgc     3960



tttgtattct attaagaaat agctcctaag gatgtagtct tgtttcatag ttgttgcact     4020



atatcaaaac ttaaaatgta agcccagttc ttctctgtat agaaaggaaa cattgtgtta     4080



cttaatgaat tatttataca gagcatttgt tgccaactgt tgttccagcc atccacacag     4140



gagtctgttc tgaggtggca atagcacatg ggaagatgaa ctttccctgt ttgtttaccc     4200



gttcttcttt ggctgtatct gatgacagta taagatgttc ttaataaagt tttatgttct     4260



ttttgaaaaa aaaaaaaaaa aaa                                             4283





<210>  195

<211>  312

<212>  PRT

<213>  Homo sapiens



<400>  195



Met Ser Ala Phe Ser Glu Ala Ala Leu Glu Lys Lys Leu Ser Glu Leu 

1               5                   10                  15      





Ser Asn Ser Gln Gln Ser Val Gln Thr Leu Ser Leu Trp Leu Ile His 

            20                  25                  30          





His Arg Lys His Ser Arg Pro Ile Val Thr Val Trp Glu Arg Glu Leu 

        35                  40                  45              





Arg Lys Ala Lys Pro Asn Arg Lys Leu Thr Phe Leu Tyr Leu Ala Asn 

    50                  55                  60                  





Asp Val Ile Gln Asn Ser Lys Arg Lys Gly Pro Glu Phe Thr Lys Asp 

65                  70                  75                  80  





Phe Ala Pro Val Ile Val Glu Ala Phe Lys His Val Ser Ser Glu Thr 

                85                  90                  95      





Asp Glu Ser Cys Lys Lys His Leu Gly Arg Val Leu Ser Ile Trp Glu 

            100                 105                 110         





Glu Arg Ser Val Tyr Glu Asn Asp Val Leu Glu Gln Leu Lys Gln Ala 

        115                 120                 125             





Leu Tyr Gly Asp Lys Lys Pro Arg Lys Arg Thr Tyr Glu Gln Ile Lys 

    130                 135                 140                 





Val Asp Glu Asn Glu Asn Cys Ser Ser Leu Gly Ser Pro Ser Glu Pro 

145                 150                 155                 160 





Pro Gln Thr Leu Asp Leu Val Arg Ala Leu Gln Asp Leu Glu Asn Ala 

                165                 170                 175     





Ala Ser Gly Asp Ala Ala Val His Gln Arg Ile Ala Ser Leu Pro Val 

            180                 185                 190         





Glu Val Gln Glu Val Ser Leu Leu Asp Lys Ile Thr Asp Lys Glu Ser 

        195                 200                 205             





Gly Glu Arg Leu Ser Lys Met Val Glu Asp Ala Cys Met Leu Leu Ala 

    210                 215                 220                 





Asp Tyr Asn Gly Arg Leu Ala Ala Glu Ile Asp Asp Arg Lys Gln Leu 

225                 230                 235                 240 





Thr Arg Met Leu Ala Asp Phe Leu Arg Cys Gln Lys Glu Ala Leu Ala 

                245                 250                 255     





Glu Lys Glu His Lys Leu Glu Glu Tyr Lys Arg Lys Leu Ala Arg Val 

            260                 265                 270         





Ser Leu Val Arg Lys Glu Leu Arg Ser Arg Ile Gln Ser Leu Pro Asp 

        275                 280                 285             





Leu Ser Arg Leu Pro Asn Val Thr Gly Ser His Met His Leu Pro Phe 

    290                 295                 300                 





Ala Gly Asp Ile Tyr Ser Glu Asp 

305                 310         





<210>  196

<211>  2041

<212>  DNA

<213>  Homo sapiens



<400>  196

aggagggagc aggcggccgg cggcgcgggg ggagggggcc cggtccggga gtgcgggagg       60



cagtggtaga gggaggtggc ggcagcggct agcggactcg agtctcaacc gggctgaggc      120



ggacacttct gtggagcgaa gcagtgggag catcgagcac tagaggcggc accgggatcc      180



ccggctccgg ggaggggggc gccggaccgg gaggagggga gggggcgatg ctggaagcca      240



tggcggagcc cagtcccgaa gatccacctc cgacccttaa gccagagact cagccaccag      300



agaaacggcg gagaacaatt gaggatttca acaaattctg cagttttgtt ttggcatatg      360



ctggttacat tccccctagc aaagaggaaa gtgactggcc agcctctggc tccagctctc      420



cattgcgagg agagagtgcg gccgacagtg atggctggga ctcggccccc tcagatcttc      480



gaaccatcca gacttttgtt aagaaagcaa agtcatccaa gagaagggca gctcaagcag      540



gtcccaccca gccaggaccc ccaaggtcca ctttctctcg tctgcaggcc cccgacagtg      600



ctaccttgct tgagaagatg aagctcaagg actctctctt tgatctggat gggcccaaag      660



tggcatctcc tttgtccccc acatccctga cacatacctc ccggccccct gctgctctta      720



cccccgtgcc cctttcccag ggggacctct cccatcctcc tcgaaagaag gaccgaaaga      780



accgaaagtt ggggccagga gctggggctg gctttggggt gcttcggagg cctcggccaa      840



ctcctgggga tggggaaaag agatctcgaa tcaagaagag caagaagcgg aagttaaaaa      900



aggcagaacg gggggataga ctcccacctc ctgggcctcc ccaggcaccc cccagtgata      960



cagactctga agaggaggag gaagaggagg aagaggaaga agaagaagag atggcaacag     1020



tggtaggggg tgaagcccca gtccctgtgc tgccaacacc ccctgaggct cctaggcccc     1080



ctgccacagt gcaccctgaa ggagtccctc ctgctgacag tgaaagcaag gaggtgggca     1140



gcactgaaac aagccaagat ggagatgcca gctccagtga aggcgagatg cgggtcatgg     1200



acgaggacat catggtagaa tcaggtgatg actcatggga tctgatcaca tgttactgtc     1260



gaaagccctt tgcagggcgg cccatgattg agtgcagcct gtgtgggacg tggatccacc     1320



tctcctgtgc taagattaag aagaccaacg tccccgactt cttttattgc cagaaatgca     1380



aggaactgag gccagaggcc cggcggttag gggggcctcc caaatctgga gagccctgat     1440



ggcaccaact ttagcctgga acttccaaat gacaacatga tttgggaact gagcctcagg     1500



gtcctcagcc tatcccctgg agcttggata ctgtctgcac ttcaaggcag gaattctcaa     1560



gggagacttg tttgaaaatg agtgtctcac tttcccaccc tatccttcct ccccactctg     1620



tggacttgaa attgaatcca ttacggttgg ggatgggagg ctgtctgtgt cccgacacat     1680



aatctctgtc tcttggacct gccaccatca ctttctgggt caggattgga attgggatgg     1740



aatgggacag ttgtctataa aactctagtg taaatattag cactcccctc cctcatcttt     1800



tcttctattt cactccccat ttattttctt ctacaccggt tgtattttta attttggact     1860



tcccctattg ggcatggcag ctcaaaggtg gagtactaga gcctggccaa gtgaggaagg     1920



aaagcagaaa ggtgacgatt ctcactcacc tcttttgttt ttaataatat cggccgctgt     1980



ttgtacagac agcctgcgtg ttgtaaataa agcagagtgg gctcttttgt gtttataaaa     2040



a                                                                     2041





<210>  197

<211>  403

<212>  PRT

<213>  Homo sapiens



<400>  197



Met Leu Glu Ala Met Ala Glu Pro Ser Pro Glu Asp Pro Pro Pro Thr 

1               5                   10                  15      





Leu Lys Pro Glu Thr Gln Pro Pro Glu Lys Arg Arg Arg Thr Ile Glu 

            20                  25                  30          





Asp Phe Asn Lys Phe Cys Ser Phe Val Leu Ala Tyr Ala Gly Tyr Ile 

        35                  40                  45              





Pro Pro Ser Lys Glu Glu Ser Asp Trp Pro Ala Ser Gly Ser Ser Ser 

    50                  55                  60                  





Pro Leu Arg Gly Glu Ser Ala Ala Asp Ser Asp Gly Trp Asp Ser Ala 

65                  70                  75                  80  





Pro Ser Asp Leu Arg Thr Ile Gln Thr Phe Val Lys Lys Ala Lys Ser 

                85                  90                  95      





Ser Lys Arg Arg Ala Ala Gln Ala Gly Pro Thr Gln Pro Gly Pro Pro 

            100                 105                 110         





Arg Ser Thr Phe Ser Arg Leu Gln Ala Pro Asp Ser Ala Thr Leu Leu 

        115                 120                 125             





Glu Lys Met Lys Leu Lys Asp Ser Leu Phe Asp Leu Asp Gly Pro Lys 

    130                 135                 140                 





Val Ala Ser Pro Leu Ser Pro Thr Ser Leu Thr His Thr Ser Arg Pro 

145                 150                 155                 160 





Pro Ala Ala Leu Thr Pro Val Pro Leu Ser Gln Gly Asp Leu Ser His 

                165                 170                 175     





Pro Pro Arg Lys Lys Asp Arg Lys Asn Arg Lys Leu Gly Pro Gly Ala 

            180                 185                 190         





Gly Ala Gly Phe Gly Val Leu Arg Arg Pro Arg Pro Thr Pro Gly Asp 

        195                 200                 205             





Gly Glu Lys Arg Ser Arg Ile Lys Lys Ser Lys Lys Arg Lys Leu Lys 

    210                 215                 220                 





Lys Ala Glu Arg Gly Asp Arg Leu Pro Pro Pro Gly Pro Pro Gln Ala 

225                 230                 235                 240 





Pro Pro Ser Asp Thr Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu 

                245                 250                 255     





Glu Glu Glu Glu Glu Met Ala Thr Val Val Gly Gly Glu Ala Pro Val 

            260                 265                 270         





Pro Val Leu Pro Thr Pro Pro Glu Ala Pro Arg Pro Pro Ala Thr Val 

        275                 280                 285             





His Pro Glu Gly Val Pro Pro Ala Asp Ser Glu Ser Lys Glu Val Gly 

    290                 295                 300                 





Ser Thr Glu Thr Ser Gln Asp Gly Asp Ala Ser Ser Ser Glu Gly Glu 

305                 310                 315                 320 





Met Arg Val Met Asp Glu Asp Ile Met Val Glu Ser Gly Asp Asp Ser 

                325                 330                 335     





Trp Asp Leu Ile Thr Cys Tyr Cys Arg Lys Pro Phe Ala Gly Arg Pro 

            340                 345                 350         





Met Ile Glu Cys Ser Leu Cys Gly Thr Trp Ile His Leu Ser Cys Ala 

        355                 360                 365             





Lys Ile Lys Lys Thr Asn Val Pro Asp Phe Phe Tyr Cys Gln Lys Cys 

    370                 375                 380                 





Lys Glu Leu Arg Pro Glu Ala Arg Arg Leu Gly Gly Pro Pro Lys Ser 

385                 390                 395                 400 





Gly Glu Pro 

            





<210>  198

<211>  1163

<212>  DNA

<213>  Homo sapiens



<400>  198

ctactgcgca ggctcagtgc tgcttaccca tcatggaagc aatgtggctc ctgtgtgtgg       60



cgttggcggt cttggcatgg ggcttcctct gggtttggga ctcctcagaa cgaatgaaga      120



gtcgggagca gggaggacgg ctgggagccg aaagccggac cctgctggtc atagcgcacc      180



ctgacgatga agccatgttt tttgctccca cagtgctagg cttggcccgc ctaaggcact      240



gggtgtacct gctttgcttc tctgcaggaa attactacaa tcaaggagag actcgtaaga      300



aagaactttt gcagagctgt gatgttttgg ggattccact ctccagtgta atgattattg      360



acaacaggga tttcccagat gacccaggca tgcagtggga cacagagcac gtggccagag      420



tcctccttca gcacatagaa gtgaatggca tcaatctggt ggtgactttc gatgcagggg      480



gagtaagtgg ccacagcaat cacattgctc tgtatgcagc tgtgagggcc ctgcactcag      540



aagggaagtt acctaaaggg tgctctgtgc tcacgcttca gtctgtgaat gtgctgcgca      600



agtacatctc ccttctggat ctgcccttgt ctctgcttca tacgcaggat gtcctcttcg      660



tgctcaacag caaagaagtg gcacaggcca agaaagccat gtcctgccac cgcagccagc      720



tcctctggtt ccgccgcctc tacattatct tctcccggta catgagaatc aactcactga      780



gcttcctctg aagccttgaa gggttttcag atccaaggaa caaaggggaa aatagacaaa      840



ggagtgcaga ggacctggcc tggcactggc ttatttacct gagctcaagg agatccccgc      900



tggagcagcc tctgcaaaag ggagcccatg taggccaggg gctgtccaaa ctccagcttc      960



ttcccctggg aaaaaaccca aagaaccaaa aacaaaccac cccaaggata ataatagcta     1020



cactgctagc ttctcaagtt cttgtgaaaa acaatttaca taatgacaca gtagatgtgg     1080



aacacctagc ccagtgcctg ggcaggtccc tattatcata aatgaacata aaagtgctct     1140



aaaaacactc caaaaaaaaa aaa                                             1163





<210>  199

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  199



Met Glu Ala Met Trp Leu Leu Cys Val Ala Leu Ala Val Leu Ala Trp 

1               5                   10                  15      





Gly Phe Leu Trp Val Trp Asp Ser Ser Glu Arg Met Lys Ser Arg Glu 

            20                  25                  30          





Gln Gly Gly Arg Leu Gly Ala Glu Ser Arg Thr Leu Leu Val Ile Ala 

        35                  40                  45              





His Pro Asp Asp Glu Ala Met Phe Phe Ala Pro Thr Val Leu Gly Leu 

    50                  55                  60                  





Ala Arg Leu Arg His Trp Val Tyr Leu Leu Cys Phe Ser Ala Gly Asn 

65                  70                  75                  80  





Tyr Tyr Asn Gln Gly Glu Thr Arg Lys Lys Glu Leu Leu Gln Ser Cys 

                85                  90                  95      





Asp Val Leu Gly Ile Pro Leu Ser Ser Val Met Ile Ile Asp Asn Arg 

            100                 105                 110         





Asp Phe Pro Asp Asp Pro Gly Met Gln Trp Asp Thr Glu His Val Ala 

        115                 120                 125             





Arg Val Leu Leu Gln His Ile Glu Val Asn Gly Ile Asn Leu Val Val 

    130                 135                 140                 





Thr Phe Asp Ala Gly Gly Val Ser Gly His Ser Asn His Ile Ala Leu 

145                 150                 155                 160 





Tyr Ala Ala Val Arg Ala Leu His Ser Glu Gly Lys Leu Pro Lys Gly 

                165                 170                 175     





Cys Ser Val Leu Thr Leu Gln Ser Val Asn Val Leu Arg Lys Tyr Ile 

            180                 185                 190         





Ser Leu Leu Asp Leu Pro Leu Ser Leu Leu His Thr Gln Asp Val Leu 

        195                 200                 205             





Phe Val Leu Asn Ser Lys Glu Val Ala Gln Ala Lys Lys Ala Met Ser 

    210                 215                 220                 





Cys His Arg Ser Gln Leu Leu Trp Phe Arg Arg Leu Tyr Ile Ile Phe 

225                 230                 235                 240 





Ser Arg Tyr Met Arg Ile Asn Ser Leu Ser Phe Leu 

                245                 250         





<210>  200

<211>  949

<212>  DNA

<213>  Homo sapiens



<400>  200

ggaaggggcg gggcgaacgg aagccgggaa ggcgattcat agctcgcggg gtacgggcgc       60



gcgtgcgcac tccgcagccc gttcaggacc ccggcgcggg cagggcgccc acgagctggc      120



tggctgcttg cacccacatc cttctttctc tgggacctgg ggtcgcggtt acttgggctg      180



gccggcgaac ccttgagtgg cctggcgggg agcgggcctc gcgcgcctgg agggccctgt      240



ggaacgaaga gaggcacaca gcatggcaga aaaccgagag ccccgcggtg ctgtggaggc      300



tgaactggat ccagtggaat acacccttag gaaaaggctt cccagccgcc tgccccggag      360



acccaatgac atttatgtca acatgaagac ggactttaag gcccagctgg cccgctgcca      420



gaagctgctg gacggagggg cccggggtca gaacgcgtgc tctgagatct acattcacgg      480



cttgggcctg gccatcaacc gcgccatcaa catcgcgctg cagctgcagg cgggcagctt      540



cgggtccttg caggtggctg ccaatacctc caccgtggag cttgttgatg agctggagcc      600



agagaccgac acacgggagc cactgactcg gatccgcaac aactcagcca tccacatccg      660



agtcttcagg gtcacaccca agtaattgaa aagacactcc tccacttatc ccctccgtga      720



tatggctctt cgcatgctga gtactggacc tcggaccaga gccatgtaag aaaaggcctg      780



ttccctggaa gcccaaagga ctctgcattg agggtggggg taattgtctc ttggtgggcc      840



cagttagtgg gccttcctga gtgtgtgtat gcggtctgta actattgcca tataaataaa      900



aaatcctgtt gcactagtgt cctgccatcc caaaaaaaaa aaaaaaaaa                  949





<210>  201

<211>  140

<212>  PRT

<213>  Homo sapiens



<400>  201



Met Ala Glu Asn Arg Glu Pro Arg Gly Ala Val Glu Ala Glu Leu Asp 

1               5                   10                  15      





Pro Val Glu Tyr Thr Leu Arg Lys Arg Leu Pro Ser Arg Leu Pro Arg 

            20                  25                  30          





Arg Pro Asn Asp Ile Tyr Val Asn Met Lys Thr Asp Phe Lys Ala Gln 

        35                  40                  45              





Leu Ala Arg Cys Gln Lys Leu Leu Asp Gly Gly Ala Arg Gly Gln Asn 

    50                  55                  60                  





Ala Cys Ser Glu Ile Tyr Ile His Gly Leu Gly Leu Ala Ile Asn Arg 

65                  70                  75                  80  





Ala Ile Asn Ile Ala Leu Gln Leu Gln Ala Gly Ser Phe Gly Ser Leu 

                85                  90                  95      





Gln Val Ala Ala Asn Thr Ser Thr Val Glu Leu Val Asp Glu Leu Glu 

            100                 105                 110         





Pro Glu Thr Asp Thr Arg Glu Pro Leu Thr Arg Ile Arg Asn Asn Ser 

        115                 120                 125             





Ala Ile His Ile Arg Val Phe Arg Val Thr Pro Lys 

    130                 135                 140 





<210>  202

<211>  3810

<212>  DNA

<213>  Homo sapiens



<400>  202

gggcacaggg gagactaaaa aggccaggga agttggcctg ccggaagttc ccagggagaa       60



ggcagcgcgt tgtacccgag attcagggtc tggctctgct tcccaggcta gagtgcattt      120



ggcgcgatca cagctcactg cagcctcgac ctcctgagct caagcgaact tcctgcctca      180



gcctcctgag cttcctgagt agctgcgact acagaaaaaa gaaatcctct ttttagaaca      240



tctcttggtg gtaccatcag aaatgtcttc cttaagtgga aaagtccaaa ccgttttggg      300



ccttgtagag ccaagcaaac tgggccgtac cctgacccat gaacacctgg ccatgacctt      360



tgactgctgt tactgtccac ctcccccgtg ccaggaagct atttccaaag aacctatcgt      420



gatgaaaaat ttatattgga ttcagaaaaa cgcctattcc cataaagaaa accttcaatt      480



aaatcaggag acagaagcca taaaggaaga actgttgtat tttaaagcta atggtggagg      540



ggctttggtg gaaaacacaa ccactgggat tagccgagac acacagacgt tgaagaggct      600



tgcagaagag actggcgtcc atatcatatc tggagccggg ttttatgtgg atgcaactca      660



ctcctcagag accagggcca tgtcagtgga gcagcttacc gatgtcctta tgaatgaaat      720



tctccatgga gctgatggaa ccagtatcaa gtgtggcatt attggagaaa ttggttgctc      780



ctggcctttg actgagagtg aaagaaaggt tctccaggcc acagctcatg cccaggctca      840



gcttggttgt cctgttatta tccatcctgg acggagctcc agggcaccat ttcagattat      900



ccgaatattg caagaagcag gcgcagacat ctccaaaaca gtcatgtcac acctggatag      960



gactattctt gataagaaag agctcttgga gtttgctcaa cttggctgct acttggaata     1020



tgatctcttt ggtactgaac tacttcatta ccaactcggc ccagatattg acatgcctga     1080



tgataacaaa agaattagaa gggtgcgtct cctggtggaa gagggctgtg aagatcgaat     1140



tctggtagca catgacatac atacgaaaac ccggctgatg aaatatggag gtcacggcta     1200



ttctcatata ctcaccaatg ttgttcctaa aatgttgctg agaggcataa ctgagaatgt     1260



gcttgataag attctaatag agaaccctaa gcaatggcta actttcaaat aggatggttg     1320



cttatgaatt cacaccttga gtataaaact tgcagagaac attcagcgat ttccagtcca     1380



ctgtgagata ttaatcagtt acctaggact aatgacagat catttccttc tgatgagaac     1440



taggagggtt tgccttctct gagaccagct attacaactg tgcctctagg gagttactca     1500



gcctaattga gccctattat tttaacttaa caaaataaat acagaagtac ctatttctaa     1560



acaatgattt aaagtctata tcccctaagc ggagttgttg tttttctccc taatctatca     1620



gctgcactac ttgagaaaat ttaaagtgtt tctagttaaa ttatttcctt cttgagcgat     1680



ctaatgtttc ttgtaatatt gatgatccta ctaattatcc tgctgttctt taattaatgc     1740



ttaatgaata atatggcact gtaaaatagc ttctgcaaca agggaagtta aattttgaga     1800



cttttttccc caaaggatac tgactgtaat acaattacca attcacaatg ataaaaatat     1860



tttgaaaggt taattttata ctgtccacct atctatatat tcttctactg aaatgatttt     1920



gatatctttg gctttccggt atctattttt gccatacatt ttgctgtttt gcaaagtttg     1980



tataagaaca cataacacta ctgaattata aaaattcaat cataaaagtc aaaatatatt     2040



acataatata gtttaatgaa tcattacatt tataataaca aaggccacaa tttaattaat     2100



tggtaagata taatgcaaaa aaaaaaagag aaatgtttgc cttatgtata ttccctttat     2160



ttcctttacc ttttgttttt ccttggacct aaacagagaa aataatgctt atgtatctga     2220



agaaaaggtc agatctattg gaaatgacag cccgatactt gagcctcctc tttaaaaggt     2280



atccagccct gatattttgt gtaaataaaa tgtttttaaa acctgttagt taaaacactt     2340



aggtgatggg cactgctgct tataaattca tcttttggtt gaatcctcac tatgctattt     2400



ggtacctaaa aatattctcc aaacccttgc tgccagttcc tctttgataa atatatagtt     2460



aattcgaaat aaaatccatt gcaattcatt tatgagttat cttacatatc acaaagacca     2520



attagaatta gtcattattc ttgatgaaga gtctgttttt aatcataaaa atcatgacag     2580



ttactcagac ccaggcattt caacagagct aacaccacct tcagataggc acaccatgca     2640



taactcttgg gaagttgagc tttgctaaat aaaagatatt tctgctgatc aaagatgatc     2700



aagctttctg tgtattggaa cagaaagtaa caaagaggaa tgagccagga gaacaaacta     2760



attcctttaa ataaataaaa aaaaaaaatg caaatgtcct tcaccagtaa agcaagcaaa     2820



tttttaaaat ctctgttttt gaaatctact cgtcaaagag ttttcagagg caatgaaagg     2880



ggaacagatt tttcattgta atagtggaag ttgtgtgata gttaggagat atcaacatgc     2940



atttttaatc ttttccttag atgaaagaga tggcttttgg cagtgtgttc taaccagaaa     3000



gaaaggattt gtattactct ccaaatctac tgtactgtca gcttcactcc acctgagaaa     3060



aaagaaaaaa aaattgatag ctcaaatgca tgtaattcat aaacactgca aaggagagcc     3120



acttggtgtc tgcagtcctc atattaacag tctgtcacag aatgcagtta aagtattgat     3180



tggcatatgg taatagagca accatagcct taacttacag acctgtgaaa taaagggcat     3240



tttgacctaa tacaattaat tttctggata actcttaaag agaagtcatt ttaactgttt     3300



ttgctactcc atatattgtc attcaaaata tattttaacc caaaataagt taaataattt     3360



gtgcatgttt gtgtgtgtat atatgcatac acttttttat attaaaattt tgaggctata     3420



cagccactgt gccctgtgga ataaagccat atatataaat gttttatatg tatatgtttt     3480



atacataaat aaaacatttc atctaatata tatatgtgtg tgtgagtata tgtgtgcatg     3540



tttagcagat atttgtataa aatataaaca ctctgttgtc atataggcta tatgcgaaat     3600



tgttaatttt aaaataacct caggccacag acttgtagta atcatttgaa ggcctcacct     3660



agtgtcccct tggtgacgta tgcagcagct caaattaaac ctttgtgcat tgggttatga     3720



ataatctttt cttccaaaga tggcaaaagc ctcggtttga tttgatacta aagaataaat     3780



ttctctgact ttcaaaaaaa aaaaaaaaaa                                      3810





<210>  203

<211>  349

<212>  PRT

<213>  Homo sapiens



<400>  203



Met Ser Ser Leu Ser Gly Lys Val Gln Thr Val Leu Gly Leu Val Glu 

1               5                   10                  15      





Pro Ser Lys Leu Gly Arg Thr Leu Thr His Glu His Leu Ala Met Thr 

            20                  25                  30          





Phe Asp Cys Cys Tyr Cys Pro Pro Pro Pro Cys Gln Glu Ala Ile Ser 

        35                  40                  45              





Lys Glu Pro Ile Val Met Lys Asn Leu Tyr Trp Ile Gln Lys Asn Ala 

    50                  55                  60                  





Tyr Ser His Lys Glu Asn Leu Gln Leu Asn Gln Glu Thr Glu Ala Ile 

65                  70                  75                  80  





Lys Glu Glu Leu Leu Tyr Phe Lys Ala Asn Gly Gly Gly Ala Leu Val 

                85                  90                  95      





Glu Asn Thr Thr Thr Gly Ile Ser Arg Asp Thr Gln Thr Leu Lys Arg 

            100                 105                 110         





Leu Ala Glu Glu Thr Gly Val His Ile Ile Ser Gly Ala Gly Phe Tyr 

        115                 120                 125             





Val Asp Ala Thr His Ser Ser Glu Thr Arg Ala Met Ser Val Glu Gln 

    130                 135                 140                 





Leu Thr Asp Val Leu Met Asn Glu Ile Leu His Gly Ala Asp Gly Thr 

145                 150                 155                 160 





Ser Ile Lys Cys Gly Ile Ile Gly Glu Ile Gly Cys Ser Trp Pro Leu 

                165                 170                 175     





Thr Glu Ser Glu Arg Lys Val Leu Gln Ala Thr Ala His Ala Gln Ala 

            180                 185                 190         





Gln Leu Gly Cys Pro Val Ile Ile His Pro Gly Arg Ser Ser Arg Ala 

        195                 200                 205             





Pro Phe Gln Ile Ile Arg Ile Leu Gln Glu Ala Gly Ala Asp Ile Ser 

    210                 215                 220                 





Lys Thr Val Met Ser His Leu Asp Arg Thr Ile Leu Asp Lys Lys Glu 

225                 230                 235                 240 





Leu Leu Glu Phe Ala Gln Leu Gly Cys Tyr Leu Glu Tyr Asp Leu Phe 

                245                 250                 255     





Gly Thr Glu Leu Leu His Tyr Gln Leu Gly Pro Asp Ile Asp Met Pro 

            260                 265                 270         





Asp Asp Asn Lys Arg Ile Arg Arg Val Arg Leu Leu Val Glu Glu Gly 

        275                 280                 285             





Cys Glu Asp Arg Ile Leu Val Ala His Asp Ile His Thr Lys Thr Arg 

    290                 295                 300                 





Leu Met Lys Tyr Gly Gly His Gly Tyr Ser His Ile Leu Thr Asn Val 

305                 310                 315                 320 





Val Pro Lys Met Leu Leu Arg Gly Ile Thr Glu Asn Val Leu Asp Lys 

                325                 330                 335     





Ile Leu Ile Glu Asn Pro Lys Gln Trp Leu Thr Phe Lys 

            340                 345                 





<210>  204

<211>  3755

<212>  DNA

<213>  Homo sapiens



<400>  204

gggcacaggg gagactaaaa aggccaggga agttggcctg ccggaagttc ccagggagaa       60



ggcagcgcgt tgtacccgag ttacctgtag tcaaccacag tctgaaaata ttaaggtatt      120



ttaagacaga aagagagaga ggagagaaac cgcattcaca aaaaagaaat cctcttttta      180



gaacatctct tggtggtacc atcagaaatg tcttccttaa gtggaaaagt ccaaaccgtt      240



ttgggccttg tagagccaag caaactgggc cgtaccctga cccatgaaca cctggccatg      300



acctttgact gctgttactg tccacctccc ccgtgccagg aagctatttc caaagaacct      360



atcgtgatga aaaatttata ttggattcag aaaaacgcct attcccataa agaaaacctt      420



caattaaatc aggagacaga agccataaag gaagaactgt tgtattttaa agctaatggt      480



ggaggggctt tggtggaaaa cacaaccact gggattagcc gagacacaca gacgttgaag      540



aggcttgcag aagagactgg cgtccatatc atatctggag ccgggtttta tgtggatgca      600



actcactcct cagagaccag ggccatgtca gtggagcagc ttaccgatgt ccttatgaat      660



gaaattctcc atggagctga tggaaccagt atcaagtgtg gcattattgg agaaattggt      720



tgctcctggc ctttgactga gagtgaaaga aaggttctcc aggccacagc tcatgcccag      780



gctcagcttg gttgtcctgt tattatccat cctggacgga gctccagggc accatttcag      840



attatccgaa tattgcaaga agcaggcgca gacatctcca aaacagtcat gtcacacctg      900



gataggacta ttcttgataa gaaagagctc ttggagtttg ctcaacttgg ctgctacttg      960



gaatatgatc tctttggtac tgaactactt cattaccaac tcggcccaga tattgacatg     1020



cctgatgata acaaaagaat tagaagggtg cgtctcctgg tggaagaggg ctgtgaagat     1080



cgaattctgg tagcacatga catacatacg aaaacccggc tgatgaaata tggaggtcac     1140



ggctattctc atatactcac caatgttgtt cctaaaatgt tgctgagagg cataactgag     1200



aatgtgcttg ataagattct aatagagaac cctaagcaat ggctaacttt caaataggat     1260



ggttgcttat gaattcacac cttgagtata aaacttgcag agaacattca gcgatttcca     1320



gtccactgtg agatattaat cagttaccta ggactaatga cagatcattt ccttctgatg     1380



agaactagga gggtttgcct tctctgagac cagctattac aactgtgcct ctagggagtt     1440



actcagccta attgagccct attattttaa cttaacaaaa taaatacaga agtacctatt     1500



tctaaacaat gatttaaagt ctatatcccc taagcggagt tgttgttttt ctccctaatc     1560



tatcagctgc actacttgag aaaatttaaa gtgtttctag ttaaattatt tccttcttga     1620



gcgatctaat gtttcttgta atattgatga tcctactaat tatcctgctg ttctttaatt     1680



aatgcttaat gaataatatg gcactgtaaa atagcttctg caacaaggga agttaaattt     1740



tgagactttt ttccccaaag gatactgact gtaatacaat taccaattca caatgataaa     1800



aatattttga aaggttaatt ttatactgtc cacctatcta tatattcttc tactgaaatg     1860



attttgatat ctttggcttt ccggtatcta tttttgccat acattttgct gttttgcaaa     1920



gtttgtataa gaacacataa cactactgaa ttataaaaat tcaatcataa aagtcaaaat     1980



atattacata atatagttta atgaatcatt acatttataa taacaaaggc cacaatttaa     2040



ttaattggta agatataatg caaaaaaaaa aagagaaatg tttgccttat gtatattccc     2100



tttatttcct ttaccttttg tttttccttg gacctaaaca gagaaaataa tgcttatgta     2160



tctgaagaaa aggtcagatc tattggaaat gacagcccga tacttgagcc tcctctttaa     2220



aaggtatcca gccctgatat tttgtgtaaa taaaatgttt ttaaaacctg ttagttaaaa     2280



cacttaggtg atgggcactg ctgcttataa attcatcttt tggttgaatc ctcactatgc     2340



tatttggtac ctaaaaatat tctccaaacc cttgctgcca gttcctcttt gataaatata     2400



tagttaattc gaaataaaat ccattgcaat tcatttatga gttatcttac atatcacaaa     2460



gaccaattag aattagtcat tattcttgat gaagagtctg tttttaatca taaaaatcat     2520



gacagttact cagacccagg catttcaaca gagctaacac caccttcaga taggcacacc     2580



atgcataact cttgggaagt tgagctttgc taaataaaag atatttctgc tgatcaaaga     2640



tgatcaagct ttctgtgtat tggaacagaa agtaacaaag aggaatgagc caggagaaca     2700



aactaattcc tttaaataaa taaaaaaaaa aaatgcaaat gtccttcacc agtaaagcaa     2760



gcaaattttt aaaatctctg tttttgaaat ctactcgtca aagagttttc agaggcaatg     2820



aaaggggaac agatttttca ttgtaatagt ggaagttgtg tgatagttag gagatatcaa     2880



catgcatttt taatcttttc cttagatgaa agagatggct tttggcagtg tgttctaacc     2940



agaaagaaag gatttgtatt actctccaaa tctactgtac tgtcagcttc actccacctg     3000



agaaaaaaga aaaaaaaatt gatagctcaa atgcatgtaa ttcataaaca ctgcaaagga     3060



gagccacttg gtgtctgcag tcctcatatt aacagtctgt cacagaatgc agttaaagta     3120



ttgattggca tatggtaata gagcaaccat agccttaact tacagacctg tgaaataaag     3180



ggcattttga cctaatacaa ttaattttct ggataactct taaagagaag tcattttaac     3240



tgtttttgct actccatata ttgtcattca aaatatattt taacccaaaa taagttaaat     3300



aatttgtgca tgtttgtgtg tgtatatatg catacacttt tttatattaa aattttgagg     3360



ctatacagcc actgtgccct gtggaataaa gccatatata taaatgtttt atatgtatat     3420



gttttataca taaataaaac atttcatcta atatatatat gtgtgtgtga gtatatgtgt     3480



gcatgtttag cagatatttg tataaaatat aaacactctg ttgtcatata ggctatatgc     3540



gaaattgtta attttaaaat aacctcaggc cacagacttg tagtaatcat ttgaaggcct     3600



cacctagtgt ccccttggtg acgtatgcag cagctcaaat taaacctttg tgcattgggt     3660



tatgaataat cttttcttcc aaagatggca aaagcctcgg tttgatttga tactaaagaa     3720



taaatttctc tgactttcaa aaaaaaaaaa aaaaa                                3755





<210>  205

<211>  349

<212>  PRT

<213>  Homo sapiens



<400>  205



Met Ser Ser Leu Ser Gly Lys Val Gln Thr Val Leu Gly Leu Val Glu 

1               5                   10                  15      





Pro Ser Lys Leu Gly Arg Thr Leu Thr His Glu His Leu Ala Met Thr 

            20                  25                  30          





Phe Asp Cys Cys Tyr Cys Pro Pro Pro Pro Cys Gln Glu Ala Ile Ser 

        35                  40                  45              





Lys Glu Pro Ile Val Met Lys Asn Leu Tyr Trp Ile Gln Lys Asn Ala 

    50                  55                  60                  





Tyr Ser His Lys Glu Asn Leu Gln Leu Asn Gln Glu Thr Glu Ala Ile 

65                  70                  75                  80  





Lys Glu Glu Leu Leu Tyr Phe Lys Ala Asn Gly Gly Gly Ala Leu Val 

                85                  90                  95      





Glu Asn Thr Thr Thr Gly Ile Ser Arg Asp Thr Gln Thr Leu Lys Arg 

            100                 105                 110         





Leu Ala Glu Glu Thr Gly Val His Ile Ile Ser Gly Ala Gly Phe Tyr 

        115                 120                 125             





Val Asp Ala Thr His Ser Ser Glu Thr Arg Ala Met Ser Val Glu Gln 

    130                 135                 140                 





Leu Thr Asp Val Leu Met Asn Glu Ile Leu His Gly Ala Asp Gly Thr 

145                 150                 155                 160 





Ser Ile Lys Cys Gly Ile Ile Gly Glu Ile Gly Cys Ser Trp Pro Leu 

                165                 170                 175     





Thr Glu Ser Glu Arg Lys Val Leu Gln Ala Thr Ala His Ala Gln Ala 

            180                 185                 190         





Gln Leu Gly Cys Pro Val Ile Ile His Pro Gly Arg Ser Ser Arg Ala 

        195                 200                 205             





Pro Phe Gln Ile Ile Arg Ile Leu Gln Glu Ala Gly Ala Asp Ile Ser 

    210                 215                 220                 





Lys Thr Val Met Ser His Leu Asp Arg Thr Ile Leu Asp Lys Lys Glu 

225                 230                 235                 240 





Leu Leu Glu Phe Ala Gln Leu Gly Cys Tyr Leu Glu Tyr Asp Leu Phe 

                245                 250                 255     





Gly Thr Glu Leu Leu His Tyr Gln Leu Gly Pro Asp Ile Asp Met Pro 

            260                 265                 270         





Asp Asp Asn Lys Arg Ile Arg Arg Val Arg Leu Leu Val Glu Glu Gly 

        275                 280                 285             





Cys Glu Asp Arg Ile Leu Val Ala His Asp Ile His Thr Lys Thr Arg 

    290                 295                 300                 





Leu Met Lys Tyr Gly Gly His Gly Tyr Ser His Ile Leu Thr Asn Val 

305                 310                 315                 320 





Val Pro Lys Met Leu Leu Arg Gly Ile Thr Glu Asn Val Leu Asp Lys 

                325                 330                 335     





Ile Leu Ile Glu Asn Pro Lys Gln Trp Leu Thr Phe Lys 

            340                 345                 





<210>  206

<211>  2791

<212>  DNA

<213>  Homo sapiens



<400>  206

tgtgtgtgtg tatgtgtgct ggtgaatgtg agtacaggga agcagcggcc gccatttcag       60



ggagcttgtc gacgctgtcg caggggtgga tcctgagctg ccgaagccgc cgtcctgctc      120



tcccgcgtgg gcttctctaa ttccattgtt ttttttagat tctctcgggc ctagccgtcc      180



ttggaacccg atattcgggc tgggcggttc cgcggcctgg gcctaggggc ttaacagtag      240



caacagaagc ggcggcggcg gcagcagcag cagcagcagc agcaatctct tcccgaacac      300



gagcaccaca ggcgcccgaa ggccggaaca ggcgtttaga gaaaatggca gacgatattg      360



atattgaagc aatgcttgag gctccttaca agaaggatga gaacaagttg agcagtgcca      420



acggccatga agaacgtagc aaaaagagga aaaaaagcaa gagcagaagt cgtagtcatg      480



aacgaaagag aagcaaaagt aaggaacgga agcgaagtag agacagagaa aggaaaaaga      540



gcaaaagccg tgaaagaaag cgaagtagaa gcaaagagag gcgacggagc cgctcaagaa      600



gtcgagatcg aagatttaga ggccgctaca gaagtcctta ctccggacca aaatttaaca      660



gtgccatccg aggaaagatt gggttgcctc atagcatcaa attaagcaga cgacgttccc      720



gaagcaaaag tccattcaga aaagacaaga gccctgtgag agaacctatt gataatttaa      780



ctcctgagga aagagatgca aggacagtct tctgtatgca gctggcggca agaattcgac      840



caagggattt ggaagagttt ttctctacag taggaaaggt tcgagatgtg aggatgattt      900



ctgacagaaa ttcaagacgt tccaaaggaa ttgcttatgt ggagttcgtc gatgttagct      960



cagtgcctct agcaatagga ttaactggcc aacgagtttt aggcgtgcca atcatagtac     1020



aggcatcaca ggcagaaaaa aacagagctg cagcaatggc aaacaattta caaaagggaa     1080



gtgctggacc tatgaggctt tatgtgggct cattacactt caacataact gaagatatgc     1140



ttcgtgggat ctttgagcct tttggaagaa ttgaaagtat ccagctgatg atggacagtg     1200



aaactggtcg atccaaggga tatggattta ttacattttc tgactcagaa tgtgccaaaa     1260



aggctttgga acaacttaat ggatttgaac tagcaggaag accaatgaaa gttggtcatg     1320



ttactgaacg tactgatgct tcgagtgcta gttcattttt ggacagtgat gaactggaaa     1380



ggactggaat tgatttggga acaactggtc gtcttcagtt aatggcaaga cttgcagagg     1440



gtacaggttt gcagattccg ccagcagcac agcaagctct acagatgagt ggctctttgg     1500



catttggtgc tgtggcagat ttgcaaacaa gactttccca gcagactgaa gcttcagctt     1560



tagctgcagc tgcctctgtt cagccacttg caacacaatg tttccaactc tctaacatgt     1620



ttaaccctca aacagaagaa gaagttggat gggataccga gattaaggat gatgtgattg     1680



aagaatgtaa taaacatgga ggagttattc atatttatgt tgacaaaaat tcagctcagg     1740



gcaatgtgta tgtgaagtgc ccatcaattg ctgcagctat tgctgctgtc aatgcattgc     1800



atggcaggtg gtttgctggt aaaatgataa cagcagcata tgtacctctt ccaacttacc     1860



acaacctgtt tcctgattct atgacagcaa cacagctact ggttccaagt agacgatgaa     1920



ggaagatata gtcccttatg tatatagctt tttttctttc ttgagaattc atcttgagtt     1980



atcttttatt tagataaaaa taaagaggca aggatctact gtcatttgta tgcaatttcc     2040



tgttaccttg aaaaaataaa aatgttaaca ggaatgcagt gtgctcattc tccctaaata     2100



gtaaatccca ctgtatacaa aactgttctc ttgttctgcc ttttaaaatg ttcatgtaga     2160



aaattaatga actataggaa tagctctagg agaacaaatg tgctttctgt aaaaaggcag     2220



accagggatg taatgttttt aatgtttcag aagcctaact ttttacacag tggttacatt     2280



tcacatttca ctaatgttga tatttggctg atggttgagc agtttctgaa atacacattt     2340



agtgtatgga aatacaagac agctaaaggg ctgtttggtt agcatctcat cttgcattct     2400



gatcaattgg caagaaaggg agatttcaaa attatatttc ttgatggtat cttttcaatt     2460



aatgtatctg taaaagtttc tttgtaaata ctatgtgttc tggtgtgtct taaaattcca     2520



aacaaaatga tccctgcatt tcctgaagat gtttaaacgt gagagtctgg taggcaaagc     2580



agtctgagaa agaaatagga aatgcagaaa taggttttgt ctggttgcat ataatctttg     2640



ctctttttaa gctctgtgag ctctgaaata tatttttggg ttacttcagt gtgtttgaca     2700



agacagcttg atatttctat caaacaaatg actttcatat tgcaacaatc tttgtaagaa     2760



ccactcaaat aaaagtctct taaaaaggcc a                                    2791





<210>  207

<211>  524

<212>  PRT

<213>  Homo sapiens



<400>  207



Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 

1               5                   10                  15      





Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 

            20                  25                  30          





Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 

        35                  40                  45              





Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 

    50                  55                  60                  





Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 

65                  70                  75                  80  





Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 

                85                  90                  95      





Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 

            100                 105                 110         





Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 

        115                 120                 125             





Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 

    130                 135                 140                 





Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 

145                 150                 155                 160 





Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 

                165                 170                 175     





Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 

            180                 185                 190         





Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 

        195                 200                 205             





Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 

    210                 215                 220                 





Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 

225                 230                 235                 240 





Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 

                245                 250                 255     





Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 

            260                 265                 270         





Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 

        275                 280                 285             





Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 

    290                 295                 300                 





Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 

305                 310                 315                 320 





Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 

                325                 330                 335     





Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 

            340                 345                 350         





Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 

        355                 360                 365             





Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 

    370                 375                 380                 





Leu Ala Phe Gly Ala Val Ala Asp Leu Gln Thr Arg Leu Ser Gln Gln 

385                 390                 395                 400 





Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala Ser Val Gln Pro Leu Ala 

                405                 410                 415     





Thr Gln Cys Phe Gln Leu Ser Asn Met Phe Asn Pro Gln Thr Glu Glu 

            420                 425                 430         





Glu Val Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 

        435                 440                 445             





Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 

    450                 455                 460                 





Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 

465                 470                 475                 480 





Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr 

                485                 490                 495     





Ala Ala Tyr Val Pro Leu Pro Thr Tyr His Asn Leu Phe Pro Asp Ser 

            500                 505                 510         





Met Thr Ala Thr Gln Leu Leu Val Pro Ser Arg Arg 

        515                 520                 





<210>  208

<211>  2809

<212>  DNA

<213>  Homo sapiens



<400>  208

tgtgtgtgtg tatgtgtgct ggtgaatgtg agtacaggga agcagcggcc gccatttcag       60



ggagcttgtc gacgctgtcg caggggtgga tcctgagctg ccgaagccgc cgtcctgctc      120



tcccgcgtgg gcttctctaa ttccattgtt ttttttagat tctctcgggc ctagccgtcc      180



ttggaacccg atattcgggc tgggcggttc cgcggcctgg gcctaggggc ttaacagtag      240



caacagaagc ggcggcggcg gcagcagcag cagcagcagc agcaatctct tcccgaacac      300



gagcaccaca ggcgcccgaa ggccggaaca ggcgtttaga gaaaatggca gacgatattg      360



atattgaagc aatgcttgag gctccttaca agaaggatga gaacaagttg agcagtgcca      420



acggccatga agaacgtagc aaaaagagga aaaaaagcaa gagcagaagt cgtagtcatg      480



aacgaaagag aagcaaaagt aaggaacgga agcgaagtag agacagagaa aggaaaaaga      540



gcaaaagccg tgaaagaaag cgaagtagaa gcaaagagag gcgacggagc cgctcaagaa      600



gtcgagatcg aagatttaga ggccgctaca gaagtcctta ctccggacca aaatttaaca      660



gtgccatccg aggaaagatt gggttgcctc atagcatcaa attaagcaga cgacgttccc      720



gaagcaaaag tccattcaga aaagacaaga gccctgtgag agaacctatt gataatttaa      780



ctcctgagga aagagatgca aggacagtct tctgtatgca gctggcggca agaattcgac      840



caagggattt ggaagagttt ttctctacag taggaaaggt tcgagatgtg aggatgattt      900



ctgacagaaa ttcaagacgt tccaaaggaa ttgcttatgt ggagttcgtc gatgttagct      960



cagtgcctct agcaatagga ttaactggcc aacgagtttt aggcgtgcca atcatagtac     1020



aggcatcaca ggcagaaaaa aacagagctg cagcaatggc aaacaattta caaaagggaa     1080



gtgctggacc tatgaggctt tatgtgggct cattacactt caacataact gaagatatgc     1140



ttcgtgggat ctttgagcct tttggaagaa ttgaaagtat ccagctgatg atggacagtg     1200



aaactggtcg atccaaggga tatggattta ttacattttc tgactcagaa tgtgccaaaa     1260



aggctttgga acaacttaat ggatttgaac tagcaggaag accaatgaaa gttggtcatg     1320



ttactgaacg tactgatgct tcgagtgcta gttcattttt ggacagtgat gaactggaaa     1380



ggactggaat tgatttggga acaactggtc gtcttcagtt aatggcaaga cttgcagagg     1440



gtacaggttt gcagattccg ccagcagcac agcaagctct acagatgagt ggctctttgg     1500



catttggtgc tgtggcagaa ttctcttttg ttatagattt gcaaacaaga ctttcccagc     1560



agactgaagc ttcagcttta gctgcagctg cctctgttca gccacttgca acacaatgtt     1620



tccaactctc taacatgttt aaccctcaaa cagaagaaga agttggatgg gataccgaga     1680



ttaaggatga tgtgattgaa gaatgtaata aacatggagg agttattcat atttatgttg     1740



acaaaaattc agctcagggc aatgtgtatg tgaagtgccc atcaattgct gcagctattg     1800



ctgctgtcaa tgcattgcat ggcaggtggt ttgctggtaa aatgataaca gcagcatatg     1860



tacctcttcc aacttaccac aacctgtttc ctgattctat gacagcaaca cagctactgg     1920



ttccaagtag acgatgaagg aagatatagt cccttatgta tatagctttt tttctttctt     1980



gagaattcat cttgagttat cttttattta gataaaaata aagaggcaag gatctactgt     2040



catttgtatg caatttcctg ttaccttgaa aaaataaaaa tgttaacagg aatgcagtgt     2100



gctcattctc cctaaatagt aaatcccact gtatacaaaa ctgttctctt gttctgcctt     2160



ttaaaatgtt catgtagaaa attaatgaac tataggaata gctctaggag aacaaatgtg     2220



ctttctgtaa aaaggcagac cagggatgta atgtttttaa tgtttcagaa gcctaacttt     2280



ttacacagtg gttacatttc acatttcact aatgttgata tttggctgat ggttgagcag     2340



tttctgaaat acacatttag tgtatggaaa tacaagacag ctaaagggct gtttggttag     2400



catctcatct tgcattctga tcaattggca agaaagggag atttcaaaat tatatttctt     2460



gatggtatct tttcaattaa tgtatctgta aaagtttctt tgtaaatact atgtgttctg     2520



gtgtgtctta aaattccaaa caaaatgatc cctgcatttc ctgaagatgt ttaaacgtga     2580



gagtctggta ggcaaagcag tctgagaaag aaataggaaa tgcagaaata ggttttgtct     2640



ggttgcatat aatctttgct ctttttaagc tctgtgagct ctgaaatata tttttgggtt     2700



acttcagtgt gtttgacaag acagcttgat atttctatca aacaaatgac tttcatattg     2760



caacaatctt tgtaagaacc actcaaataa aagtctctta aaaaggcca                 2809





<210>  209

<211>  530

<212>  PRT

<213>  Homo sapiens



<400>  209



Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 

1               5                   10                  15      





Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 

            20                  25                  30          





Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 

        35                  40                  45              





Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 

    50                  55                  60                  





Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 

65                  70                  75                  80  





Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 

                85                  90                  95      





Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 

            100                 105                 110         





Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 

        115                 120                 125             





Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 

    130                 135                 140                 





Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 

145                 150                 155                 160 





Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 

                165                 170                 175     





Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 

            180                 185                 190         





Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 

        195                 200                 205             





Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 

    210                 215                 220                 





Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 

225                 230                 235                 240 





Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 

                245                 250                 255     





Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 

            260                 265                 270         





Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 

        275                 280                 285             





Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 

    290                 295                 300                 





Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 

305                 310                 315                 320 





Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 

                325                 330                 335     





Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 

            340                 345                 350         





Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 

        355                 360                 365             





Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 

    370                 375                 380                 





Leu Ala Phe Gly Ala Val Ala Glu Phe Ser Phe Val Ile Asp Leu Gln 

385                 390                 395                 400 





Thr Arg Leu Ser Gln Gln Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala 

                405                 410                 415     





Ser Val Gln Pro Leu Ala Thr Gln Cys Phe Gln Leu Ser Asn Met Phe 

            420                 425                 430         





Asn Pro Gln Thr Glu Glu Glu Val Gly Trp Asp Thr Glu Ile Lys Asp 

        435                 440                 445             





Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 

    450                 455                 460                 





Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys Pro Ser 

465                 470                 475                 480 





Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg Trp Phe 

                485                 490                 495     





Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr Tyr His 

            500                 505                 510         





Asn Leu Phe Pro Asp Ser Met Thr Ala Thr Gln Leu Leu Val Pro Ser 

        515                 520                 525             





Arg Arg 

    530 





<210>  210

<211>  2457

<212>  DNA

<213>  Homo sapiens



<400>  210

ggagcgcgtg aggctccggc gcgcaagccc ggagcagccc gctggggcgc acagggtcgc       60



gcgggcgcgg ggatggagga cggcgtggcc ggtccccagc tcggggccgc ggcggaggcg      120



gcggaggcgg ccgaggcgcg agcgcggccc ggggtgacgc tgcggccctt cgcgcccctc      180



tcgggggcgg ccgaggcgga cgagggcggc ggcgactgga gcttcattga ctgcgagatg      240



gaggaggtgg acctgcagga cctgcccagc gccaccatcg cctgtcacct ggacccgcgc      300



gtgttcgtgg acggcctgtg ccgggccaaa tttgagtccc tctttaggac gtatgacaag      360



gacatcacct ttcagtattt taagagcttc aaacgagtca gaataaactt cagcaacccc      420



ttctccgcag cagatgccag gctccagctg cataagactg agtttctggg aaaggaaatg      480



aagttatatt ttgctcagac cttacacata ggaagctcac acctggctcc gccaaatcca      540



gacaagcagt ttctgatctc ccctcccgcc tctccgccag tgggatggaa acaagtggaa      600



gatgcgaccc cagtcataaa ctatgatctc ttatatgcca tctccaagct ggggccaggg      660



gaaaagtatg aattgcacgc agcgactgac accactccca gcgtggtggt ccatgtatgt      720



gagagtgatc aagagaagga ggaagaagag gaaatggaaa gaatgaggag acctaagcca      780



aaaattatcc agaccaggag gccggagtac acgccgatcc acctcagctg aactggcacg      840



cgacgaggac gcattccaaa tcatactcac gggaggaatc ttttactgtg gaggtggctg      900



gtcacgactt cttcggaggt ggcagccgag atcggggtgg cagaaatccc agttcatgtt      960



gctcagaaga gaatcaaggc cgtgtcccct tgttctaatg ctgcacacca gttactgttc     1020



atggcacccg ggaatgactt gggccaatca ctgagtttgt ggtgatcgca caaggacatt     1080



tgggactgtc ttgagaaaac agataatgat agtgttttgt acttgttctt ttctggtagg     1140



ttctgtctgt gccaagggca ggttgatcag tgagctcagg agagagcttc ctgtttctaa     1200



gtggcctgca ggggccactc tctactggta ggaagaggta ccacaggaag ccgcctagtg     1260



cagagaggtt gtgaaaacag cagcaatgca atgtggaaat tgtagcgttt cctttcttcc     1320



ctcatgttct catgtttgtg catgtatatt actgatttac aagactaacc tttgttcgta     1380



tataaagtta caccgttgtt gttttacatc ttttgggaag ccaggaaagc gtttggaaaa     1440



cgtatcacct ttcccagatt ctcggattct cgactctttg caacagcact tgcttgcgga     1500



actcttcctg gaatgcattc actcagcatc cccaaccgtg caacgtgtaa cttgtgcttt     1560



tgcaaaagaa gttgatctga aattcctctg tagaatttag cttatacaat tcagagaata     1620



gcagtttcac tgccaacttt tagtgggtga gaaattttag tttaggtgtt tgggatcgga     1680



cctcagtttc tgttgtttct tttatgtggt ggtttctata catgaatcat agccaaaaac     1740



ttttttggaa actgttggtt gagatagttg gttcttttac cccacgaaga catcaagata     1800



cacttgtaaa taaagctgat agcatatatt catacctgtt gtacacttgg gtgaaaagta     1860



tggcagtggg agactaagat gtattaacct acctgtgaat catatgttgt aggaaaagct     1920



gttcccatgt ctaacaggac ttgaattcaa agcatgtcaa gtggatagta gatctgtggc     1980



gatatgagag ggatgcagtg cctttcccca ttcattcctg atggaattgt tatactaggt     2040



taacatttgt aatttttttc tagttgtaat gtgtatgtct ggtaaatagg tattatattt     2100



tggccttaca ataccgtaac aatgtttgtc attttgaaat acttaatgcc aagtaacaat     2160



gcatgctttg gaaatttgga agatggtttt attctttgag aagcaaatat gtttgcatta     2220



aatgctttga ttgttcatat caagaaattg attgaacgtt ctcaaaccct gtttacggta     2280



cttggtaaga gggagccggt ttgggagaga ccattgcatc gctgtccaag tgtttcttgt     2340



taagtgcttt taaactggag aggctaacct caaaatattt tttttaactg cattctataa     2400



taaatgggca cagtatgctc cttacagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        2457





<210>  211

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  211



Met Glu Asp Gly Val Ala Gly Pro Gln Leu Gly Ala Ala Ala Glu Ala 

1               5                   10                  15      





Ala Glu Ala Ala Glu Ala Arg Ala Arg Pro Gly Val Thr Leu Arg Pro 

            20                  25                  30          





Phe Ala Pro Leu Ser Gly Ala Ala Glu Ala Asp Glu Gly Gly Gly Asp 

        35                  40                  45              





Trp Ser Phe Ile Asp Cys Glu Met Glu Glu Val Asp Leu Gln Asp Leu 

    50                  55                  60                  





Pro Ser Ala Thr Ile Ala Cys His Leu Asp Pro Arg Val Phe Val Asp 

65                  70                  75                  80  





Gly Leu Cys Arg Ala Lys Phe Glu Ser Leu Phe Arg Thr Tyr Asp Lys 

                85                  90                  95      





Asp Ile Thr Phe Gln Tyr Phe Lys Ser Phe Lys Arg Val Arg Ile Asn 

            100                 105                 110         





Phe Ser Asn Pro Phe Ser Ala Ala Asp Ala Arg Leu Gln Leu His Lys 

        115                 120                 125             





Thr Glu Phe Leu Gly Lys Glu Met Lys Leu Tyr Phe Ala Gln Thr Leu 

    130                 135                 140                 





His Ile Gly Ser Ser His Leu Ala Pro Pro Asn Pro Asp Lys Gln Phe 

145                 150                 155                 160 





Leu Ile Ser Pro Pro Ala Ser Pro Pro Val Gly Trp Lys Gln Val Glu 

                165                 170                 175     





Asp Ala Thr Pro Val Ile Asn Tyr Asp Leu Leu Tyr Ala Ile Ser Lys 

            180                 185                 190         





Leu Gly Pro Gly Glu Lys Tyr Glu Leu His Ala Ala Thr Asp Thr Thr 

        195                 200                 205             





Pro Ser Val Val Val His Val Cys Glu Ser Asp Gln Glu Lys Glu Glu 

    210                 215                 220                 





Glu Glu Glu Met Glu Arg Met Arg Arg Pro Lys Pro Lys Ile Ile Gln 

225                 230                 235                 240 





Thr Arg Arg Pro Glu Tyr Thr Pro Ile His Leu Ser 

                245                 250         





<210>  212

<211>  2302

<212>  DNA

<213>  Homo sapiens



<400>  212

ccccctgcgc tctcgccatc gccccgcatt tactcgctgg aggagggggt cacctcattc       60



ctagggagga ggaaacagac attgagcggc gacgtgactc agtgttcata aataggacga      120



cgtccctgca ttcccaatct gcactattgg aagaaaagcc aatgtttggg ccaaatttga      180



gtccctcttt aggacgtatg acaaggacat cacctttcag tattttaaga gcttcaaacg      240



agtcagaata aacttcagca accccttctc cgcagcagat gccaggctcc agctgcataa      300



gactgagttt ctgggaaagg aaatgaagtt atattttgct cagaccttac acataggaag      360



ctcacacctg gctccgccaa atccagacaa gcagtttctg atctcccctc ccgcctctcc      420



gccagtggga tggaaacaag tggaagatgc gaccccagtc ataaactatg atctcttata      480



tgccatctcc aagctggggc caggggaaaa gtatgaattg cacgcagcga ctgacaccac      540



tcccagcgtg gtggtccatg tatgtgagag tgatcaagag aaggaggaag aagaggaaat      600



ggaaagaatg aggagaccta agccaaaaat tatccagacc aggaggccgg agtacacgcc      660



gatccacctc agctgaactg gcacgcgacg aggacgcatt ccaaatcata ctcacgggag      720



gaatctttta ctgtggaggt ggctggtcac gacttcttcg gaggtggcag ccgagatcgg      780



ggtggcagaa atcccagttc atgttgctca gaagagaatc aaggccgtgt ccccttgttc      840



taatgctgca caccagttac tgttcatggc acccgggaat gacttgggcc aatcactgag      900



tttgtggtga tcgcacaagg acatttggga ctgtcttgag aaaacagata atgatagtgt      960



tttgtacttg ttcttttctg gtaggttctg tctgtgccaa gggcaggttg atcagtgagc     1020



tcaggagaga gcttcctgtt tctaagtggc ctgcaggggc cactctctac tggtaggaag     1080



aggtaccaca ggaagccgcc tagtgcagag aggttgtgaa aacagcagca atgcaatgtg     1140



gaaattgtag cgtttccttt cttccctcat gttctcatgt ttgtgcatgt atattactga     1200



tttacaagac taacctttgt tcgtatataa agttacaccg ttgttgtttt acatcttttg     1260



ggaagccagg aaagcgtttg gaaaacgtat cacctttccc agattctcgg attctcgact     1320



ctttgcaaca gcacttgctt gcggaactct tcctggaatg cattcactca gcatccccaa     1380



ccgtgcaacg tgtaacttgt gcttttgcaa aagaagttga tctgaaattc ctctgtagaa     1440



tttagcttat acaattcaga gaatagcagt ttcactgcca acttttagtg ggtgagaaat     1500



tttagtttag gtgtttggga tcggacctca gtttctgttg tttcttttat gtggtggttt     1560



ctatacatga atcatagcca aaaacttttt tggaaactgt tggttgagat agttggttct     1620



tttaccccac gaagacatca agatacactt gtaaataaag ctgatagcat atattcatac     1680



ctgttgtaca cttgggtgaa aagtatggca gtgggagact aagatgtatt aacctacctg     1740



tgaatcatat gttgtaggaa aagctgttcc catgtctaac aggacttgaa ttcaaagcat     1800



gtcaagtgga tagtagatct gtggcgatat gagagggatg cagtgccttt ccccattcat     1860



tcctgatgga attgttatac taggttaaca tttgtaattt ttttctagtt gtaatgtgta     1920



tgtctggtaa ataggtatta tattttggcc ttacaatacc gtaacaatgt ttgtcatttt     1980



gaaatactta atgccaagta acaatgcatg ctttggaaat ttggaagatg gttttattct     2040



ttgagaagca aatatgtttg cattaaatgc tttgattgtt catatcaaga aattgattga     2100



acgttctcaa accctgttta cggtacttgg taagagggag ccggtttggg agagaccatt     2160



gcatcgctgt ccaagtgttt cttgttaagt gcttttaaac tggagaggct aacctcaaaa     2220



tatttttttt aactgcattc tataataaat gggcacagta tgctccttac agaaaaaaaa     2280



aaaaaaaaaa aaaaaaaaaa aa                                              2302





<210>  213

<211>  117

<212>  PRT

<213>  Homo sapiens



<400>  213



Met Lys Leu Tyr Phe Ala Gln Thr Leu His Ile Gly Ser Ser His Leu 

1               5                   10                  15      





Ala Pro Pro Asn Pro Asp Lys Gln Phe Leu Ile Ser Pro Pro Ala Ser 

            20                  25                  30          





Pro Pro Val Gly Trp Lys Gln Val Glu Asp Ala Thr Pro Val Ile Asn 

        35                  40                  45              





Tyr Asp Leu Leu Tyr Ala Ile Ser Lys Leu Gly Pro Gly Glu Lys Tyr 

    50                  55                  60                  





Glu Leu His Ala Ala Thr Asp Thr Thr Pro Ser Val Val Val His Val 

65                  70                  75                  80  





Cys Glu Ser Asp Gln Glu Lys Glu Glu Glu Glu Glu Met Glu Arg Met 

                85                  90                  95      





Arg Arg Pro Lys Pro Lys Ile Ile Gln Thr Arg Arg Pro Glu Tyr Thr 

            100                 105                 110         





Pro Ile His Leu Ser 

        115         





<210>  214

<211>  2434

<212>  DNA

<213>  Homo sapiens



<400>  214

tgtctgcctg caagcatgca ggacttgact caggaatttg ctgtccaaac aggatgctgt       60



ggaagctgca cttttttttt ccccagggag tgggggctgg cccttactgc tttataagca      120



ccagctcaag aaggaaccta cagcctcttg gaaaggaatc tcactagggg cttgactgcg      180



tgggtctgta gcgctttcac tgtaagaaag caagatgcat tttagaaact ttaactacag      240



ttttagctcc ctgattgcct gtgtggcaaa cagtgatatc ttcagcgaaa gtgaaaccag      300



ggccaaattt gagtccctct ttaggacgta tgacaaggac atcacctttc agtattttaa      360



gagcttcaaa cgagtcagaa taaacttcag caaccccttc tccgcagcag atgccaggct      420



ccagctgcat aagactgagt ttctgggaaa ggaaatgaag ttatattttg ctcagacctt      480



acacatagga agctcacacc tggctccgcc aaatccagac aagcagtttc tgatctcccc      540



tcccgcctct ccgccagtgg gatggaaaca agtggaagat gcgaccccag tcataaacta      600



tgatctctta tatgccatct ccaagctggg gccaggggaa aagtatgaat tgcacgcagc      660



gactgacacc actcccagcg tggtggtcca tgtatgtgag agtgatcaag agaaggagga      720



agaagaggaa atggaaagaa tgaggagacc taagccaaaa attatccaga ccaggaggcc      780



ggagtacacg ccgatccacc tcagctgaac tggcacgcga cgaggacgca ttccaaatca      840



tactcacggg aggaatcttt tactgtggag gtggctggtc acgacttctt cggaggtggc      900



agccgagatc ggggtggcag aaatcccagt tcatgttgct cagaagagaa tcaaggccgt      960



gtccccttgt tctaatgctg cacaccagtt actgttcatg gcacccggga atgacttggg     1020



ccaatcactg agtttgtggt gatcgcacaa ggacatttgg gactgtcttg agaaaacaga     1080



taatgatagt gttttgtact tgttcttttc tggtaggttc tgtctgtgcc aagggcaggt     1140



tgatcagtga gctcaggaga gagcttcctg tttctaagtg gcctgcaggg gccactctct     1200



actggtagga agaggtacca caggaagccg cctagtgcag agaggttgtg aaaacagcag     1260



caatgcaatg tggaaattgt agcgtttcct ttcttccctc atgttctcat gtttgtgcat     1320



gtatattact gatttacaag actaaccttt gttcgtatat aaagttacac cgttgttgtt     1380



ttacatcttt tgggaagcca ggaaagcgtt tggaaaacgt atcacctttc ccagattctc     1440



ggattctcga ctctttgcaa cagcacttgc ttgcggaact cttcctggaa tgcattcact     1500



cagcatcccc aaccgtgcaa cgtgtaactt gtgcttttgc aaaagaagtt gatctgaaat     1560



tcctctgtag aatttagctt atacaattca gagaatagca gtttcactgc caacttttag     1620



tgggtgagaa attttagttt aggtgtttgg gatcggacct cagtttctgt tgtttctttt     1680



atgtggtggt ttctatacat gaatcatagc caaaaacttt tttggaaact gttggttgag     1740



atagttggtt cttttacccc acgaagacat caagatacac ttgtaaataa agctgatagc     1800



atatattcat acctgttgta cacttgggtg aaaagtatgg cagtgggaga ctaagatgta     1860



ttaacctacc tgtgaatcat atgttgtagg aaaagctgtt cccatgtcta acaggacttg     1920



aattcaaagc atgtcaagtg gatagtagat ctgtggcgat atgagaggga tgcagtgcct     1980



ttccccattc attcctgatg gaattgttat actaggttaa catttgtaat ttttttctag     2040



ttgtaatgtg tatgtctggt aaataggtat tatattttgg ccttacaata ccgtaacaat     2100



gtttgtcatt ttgaaatact taatgccaag taacaatgca tgctttggaa atttggaaga     2160



tggttttatt ctttgagaag caaatatgtt tgcattaaat gctttgattg ttcatatcaa     2220



gaaattgatt gaacgttctc aaaccctgtt tacggtactt ggtaagaggg agccggtttg     2280



ggagagacca ttgcatcgct gtccaagtgt ttcttgttaa gtgcttttaa actggagagg     2340



ctaacctcaa aatatttttt ttaactgcat tctataataa atgggcacag tatgctcctt     2400



acagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 2434





<210>  215

<211>  197

<212>  PRT

<213>  Homo sapiens



<400>  215



Met His Phe Arg Asn Phe Asn Tyr Ser Phe Ser Ser Leu Ile Ala Cys 

1               5                   10                  15      





Val Ala Asn Ser Asp Ile Phe Ser Glu Ser Glu Thr Arg Ala Lys Phe 

            20                  25                  30          





Glu Ser Leu Phe Arg Thr Tyr Asp Lys Asp Ile Thr Phe Gln Tyr Phe 

        35                  40                  45              





Lys Ser Phe Lys Arg Val Arg Ile Asn Phe Ser Asn Pro Phe Ser Ala 

    50                  55                  60                  





Ala Asp Ala Arg Leu Gln Leu His Lys Thr Glu Phe Leu Gly Lys Glu 

65                  70                  75                  80  





Met Lys Leu Tyr Phe Ala Gln Thr Leu His Ile Gly Ser Ser His Leu 

                85                  90                  95      





Ala Pro Pro Asn Pro Asp Lys Gln Phe Leu Ile Ser Pro Pro Ala Ser 

            100                 105                 110         





Pro Pro Val Gly Trp Lys Gln Val Glu Asp Ala Thr Pro Val Ile Asn 

        115                 120                 125             





Tyr Asp Leu Leu Tyr Ala Ile Ser Lys Leu Gly Pro Gly Glu Lys Tyr 

    130                 135                 140                 





Glu Leu His Ala Ala Thr Asp Thr Thr Pro Ser Val Val Val His Val 

145                 150                 155                 160 





Cys Glu Ser Asp Gln Glu Lys Glu Glu Glu Glu Glu Met Glu Arg Met 

                165                 170                 175     





Arg Arg Pro Lys Pro Lys Ile Ile Gln Thr Arg Arg Pro Glu Tyr Thr 

            180                 185                 190         





Pro Ile His Leu Ser 

        195         





<210>  216

<211>  2532

<212>  DNA

<213>  Homo sapiens



<400>  216

tgcagagcgc atgctctggg gcagttcgcg gcccggcggg gagcgccgga gttccttgtg       60



gccgacgtgc accaaggaca ggaagatgtc acccaagcgc atagctaaaa gaaggtcccc      120



cccagcagat gccatcccca aaagcaagaa ggtgaaggac acgagggccg ctgcctcccg      180



ccgcgttcct ggcgcccgct cctgccaagg tgcctgcggg ccgagccctc ctgaccagaa      240



aacccgacca gtctcacaca ggtcccacag cacagaaccc ggcttggtgc tgacactagg      300



ccagggcgac gtgggccagc tggggctggg tgagaatgtg atggagagga agaagccggc      360



cctggtatcc attccggagg atgttgtgca ggctgaggct gggggcatgc acaccgtgtg      420



tctaagcaaa agtggccagg tctattcctt cggctgcaat gatgagggtg ccctgggaag      480



ggacacatca gtggagggct cggagatggt ccctgggaaa gtggagctgc aagagaaggt      540



ggtacaggtg tcagcaggag acagtcacac agcagccctc accgatgatg gccgtgtctt      600



cctctggggc tccttccggg acaataacgg tgtgattgga ctgttggagc ccatgaagaa      660



gagcatggtg cctgtgcagg tgcagctgga tgtgcctgtg gtaaaggtgg cctcaggaaa      720



cgaccacttg gtgatgctga cagctgatgg tgacctctac accttgggct gcggggaaca      780



gggccagcta ggccgtgtgc ctgagttatt tgccaaccgt ggtggccggc aaggcctcga      840



acgactcctg gtccccaagt gtgtgatgct gaaatccagg ggaagccggg gccacgtgag      900



attccaggat gccttttgtg gtgcctattt cacctttgcc atctcccatg agggccacgt      960



gtacggcttc ggcctctcca actaccatca gcttggaact ccgggcacag aatcttgctt     1020



cataccccag aacctaacat ccttcaagaa ttccaccaag tcctgggtgg gcttctctgg     1080



tggccagcac catacagtct gcatggattc ggaaggaaaa gcatacagcc tgggccgggc     1140



tgagtatggg cggctgggcc ttggagaggg tgctgaggag aagagcatac ccaccctcat     1200



ctccaggctg cctgctgtct cctcggtggc ttgtggggcc tctgtggggt atgctgtgac     1260



caaggatggt cgtgttttcg cctggggcat gggcaccaac taccagctgg gcacagggca     1320



ggatgaggac gcctggagcc ctgtggagat gatgggcaaa cagctggaga accgtgtggt     1380



cttatctgtg tccagcgggg gccagcatac agtcttatta gtcaaggaca aagaacagag     1440



ctgatgaagc ctctgagggc ctggcttctg tcctgcacaa cctccctcac agaacaggga     1500



agcagtgaca gctgcagatg gcagcgggcc tctccccagc cctgagcact gtgtcagttc     1560



ctgccttttc tcatcagcag aacagaatcc ttttcctctt ttccttcctc ctctttggaa     1620



ttttcctggg acctacagaa taaagggggg gatggacagg gggttttcaa aaggaacatg     1680



gctcactcag agctatatgg ttagacgttt ctcccctttt ccctaccttc catggtcctg     1740



gttggccctg gctttgccta ctagaaaacc aaaacttccc ccctggggtt ttgtgcccac     1800



tctctgagaa gttggggctc catcaagccc cattctagtc atgtgcccct ttcctgtccc     1860



taacagtcca caggcaaaca aatggtacag tcataagagc catctgtcac ggacccacgc     1920



ccagaggaac gtgcagaaaa aagcagagct acatggctgt gggcaactat aagccaaata     1980



tttggctcag aacaggtgtc catgggacaa aaaagaacga tcctccactt gaccaagaaa     2040



aaagtgattc tcccagaagc acaaagcata ctcttgcccc tcaggtgttg cttgtgtaca     2100



tcgtacccat ccattcggct tcacctgcag ccaacggcct ggaatcgcaa agagacacca     2160



ctctgggcag agcagagcag ggtatggggt ggggagagag ggtggagggt tttataaaca     2220



aacttaacag caatattgaa aggaggtggg ggattgaggg agggacagag tgttggaggg     2280



ccagagacta gtcctgagat ggaaacagca acttgtacag tggctgagaa aataggatat     2340



agttttgatt tttttaattg taaaatattt tggagggaga acaaaatctt ttaacatttt     2400



gaataaattt agagttttat aaaataggcc acttgttttc tacacattcc ctgcttttta     2460



agggagcaca tattatgtgc caggcactgc tgggaaagac agaataaact ataaacctgg     2520



tgttgaggct ac                                                         2532





<210>  217

<211>  452

<212>  PRT

<213>  Homo sapiens



<400>  217



Met Ser Pro Lys Arg Ile Ala Lys Arg Arg Ser Pro Pro Ala Asp Ala 

1               5                   10                  15      





Ile Pro Lys Ser Lys Lys Val Lys Asp Thr Arg Ala Ala Ala Ser Arg 

            20                  25                  30          





Arg Val Pro Gly Ala Arg Ser Cys Gln Gly Ala Cys Gly Pro Ser Pro 

        35                  40                  45              





Pro Asp Gln Lys Thr Arg Pro Val Ser His Arg Ser His Ser Thr Glu 

    50                  55                  60                  





Pro Gly Leu Val Leu Thr Leu Gly Gln Gly Asp Val Gly Gln Leu Gly 

65                  70                  75                  80  





Leu Gly Glu Asn Val Met Glu Arg Lys Lys Pro Ala Leu Val Ser Ile 

                85                  90                  95      





Pro Glu Asp Val Val Gln Ala Glu Ala Gly Gly Met His Thr Val Cys 

            100                 105                 110         





Leu Ser Lys Ser Gly Gln Val Tyr Ser Phe Gly Cys Asn Asp Glu Gly 

        115                 120                 125             





Ala Leu Gly Arg Asp Thr Ser Val Glu Gly Ser Glu Met Val Pro Gly 

    130                 135                 140                 





Lys Val Glu Leu Gln Glu Lys Val Val Gln Val Ser Ala Gly Asp Ser 

145                 150                 155                 160 





His Thr Ala Ala Leu Thr Asp Asp Gly Arg Val Phe Leu Trp Gly Ser 

                165                 170                 175     





Phe Arg Asp Asn Asn Gly Val Ile Gly Leu Leu Glu Pro Met Lys Lys 

            180                 185                 190         





Ser Met Val Pro Val Gln Val Gln Leu Asp Val Pro Val Val Lys Val 

        195                 200                 205             





Ala Ser Gly Asn Asp His Leu Val Met Leu Thr Ala Asp Gly Asp Leu 

    210                 215                 220                 





Tyr Thr Leu Gly Cys Gly Glu Gln Gly Gln Leu Gly Arg Val Pro Glu 

225                 230                 235                 240 





Leu Phe Ala Asn Arg Gly Gly Arg Gln Gly Leu Glu Arg Leu Leu Val 

                245                 250                 255     





Pro Lys Cys Val Met Leu Lys Ser Arg Gly Ser Arg Gly His Val Arg 

            260                 265                 270         





Phe Gln Asp Ala Phe Cys Gly Ala Tyr Phe Thr Phe Ala Ile Ser His 

        275                 280                 285             





Glu Gly His Val Tyr Gly Phe Gly Leu Ser Asn Tyr His Gln Leu Gly 

    290                 295                 300                 





Thr Pro Gly Thr Glu Ser Cys Phe Ile Pro Gln Asn Leu Thr Ser Phe 

305                 310                 315                 320 





Lys Asn Ser Thr Lys Ser Trp Val Gly Phe Ser Gly Gly Gln His His 

                325                 330                 335     





Thr Val Cys Met Asp Ser Glu Gly Lys Ala Tyr Ser Leu Gly Arg Ala 

            340                 345                 350         





Glu Tyr Gly Arg Leu Gly Leu Gly Glu Gly Ala Glu Glu Lys Ser Ile 

        355                 360                 365             





Pro Thr Leu Ile Ser Arg Leu Pro Ala Val Ser Ser Val Ala Cys Gly 

    370                 375                 380                 





Ala Ser Val Gly Tyr Ala Val Thr Lys Asp Gly Arg Val Phe Ala Trp 

385                 390                 395                 400 





Gly Met Gly Thr Asn Tyr Gln Leu Gly Thr Gly Gln Asp Glu Asp Ala 

                405                 410                 415     





Trp Ser Pro Val Glu Met Met Gly Lys Gln Leu Glu Asn Arg Val Val 

            420                 425                 430         





Leu Ser Val Ser Ser Gly Gly Gln His Thr Val Leu Leu Val Lys Asp 

        435                 440                 445             





Lys Glu Gln Ser 

    450         





<210>  218

<211>  2490

<212>  DNA

<213>  Homo sapiens



<400>  218

tgcagagcgc atgctctggg gcagttcgcg gcccggcggg gagcgccgga gttccttgtg       60



gccgacgtgc accaaggaca ggaagatgtc acccaagcgc atagctaaaa gaaggtcccc      120



cccagcagat gccatcccca aaagcaagaa ggtgaaggac acgagggccg ctgcctcccg      180



ccgcgttcct ggcgcccgct cctgccaagt ctcacacagg tcccacagca cagaacccgg      240



cttggtgctg acactaggcc agggcgacgt gggccagctg gggctgggtg agaatgtgat      300



ggagaggaag aagccggccc tggtatccat tccggaggat gttgtgcagg ctgaggctgg      360



gggcatgcac accgtgtgtc taagcaaaag tggccaggtc tattccttcg gctgcaatga      420



tgagggtgcc ctgggaaggg acacatcagt ggagggctcg gagatggtcc ctgggaaagt      480



ggagctgcaa gagaaggtgg tacaggtgtc agcaggagac agtcacacag cagccctcac      540



cgatgatggc cgtgtcttcc tctggggctc cttccgggac aataacggtg tgattggact      600



gttggagccc atgaagaaga gcatggtgcc tgtgcaggtg cagctggatg tgcctgtggt      660



aaaggtggcc tcaggaaacg accacttggt gatgctgaca gctgatggtg acctctacac      720



cttgggctgc ggggaacagg gccagctagg ccgtgtgcct gagttatttg ccaaccgtgg      780



tggccggcaa ggcctcgaac gactcctggt ccccaagtgt gtgatgctga aatccagggg      840



aagccggggc cacgtgagat tccaggatgc cttttgtggt gcctatttca cctttgccat      900



ctcccatgag ggccacgtgt acggcttcgg cctctccaac taccatcagc ttggaactcc      960



gggcacagaa tcttgcttca taccccagaa cctaacatcc ttcaagaatt ccaccaagtc     1020



ctgggtgggc ttctctggtg gccagcacca tacagtctgc atggattcgg aaggaaaagc     1080



atacagcctg ggccgggctg agtatgggcg gctgggcctt ggagagggtg ctgaggagaa     1140



gagcataccc accctcatct ccaggctgcc tgctgtctcc tcggtggctt gtggggcctc     1200



tgtggggtat gctgtgacca aggatggtcg tgttttcgcc tggggcatgg gcaccaacta     1260



ccagctgggc acagggcagg atgaggacgc ctggagccct gtggagatga tgggcaaaca     1320



gctggagaac cgtgtggtct tatctgtgtc cagcgggggc cagcatacag tcttattagt     1380



caaggacaaa gaacagagct gatgaagcct ctgagggcct ggcttctgtc ctgcacaacc     1440



tccctcacag aacagggaag cagtgacagc tgcagatggc agcgggcctc tccccagccc     1500



tgagcactgt gtcagttcct gccttttctc atcagcagaa cagaatcctt ttcctctttt     1560



ccttcctcct ctttggaatt ttcctgggac ctacagaata aaggggggga tggacagggg     1620



gttttcaaaa ggaacatggc tcactcagag ctatatggtt agacgtttct ccccttttcc     1680



ctaccttcca tggtcctggt tggccctggc tttgcctact agaaaaccaa aacttccccc     1740



ctggggtttt gtgcccactc tctgagaagt tggggctcca tcaagcccca ttctagtcat     1800



gtgccccttt cctgtcccta acagtccaca ggcaaacaaa tggtacagtc ataagagcca     1860



tctgtcacgg acccacgccc agaggaacgt gcagaaaaaa gcagagctac atggctgtgg     1920



gcaactataa gccaaatatt tggctcagaa caggtgtcca tgggacaaaa aagaacgatc     1980



ctccacttga ccaagaaaaa agtgattctc ccagaagcac aaagcatact cttgcccctc     2040



aggtgttgct tgtgtacatc gtacccatcc attcggcttc acctgcagcc aacggcctgg     2100



aatcgcaaag agacaccact ctgggcagag cagagcaggg tatggggtgg ggagagaggg     2160



tggagggttt tataaacaaa cttaacagca atattgaaag gaggtggggg attgagggag     2220



ggacagagtg ttggagggcc agagactagt cctgagatgg aaacagcaac ttgtacagtg     2280



gctgagaaaa taggatatag ttttgatttt tttaattgta aaatattttg gagggagaac     2340



aaaatctttt aacattttga ataaatttag agttttataa aataggccac ttgttttcta     2400



cacattccct gctttttaag ggagcacata ttatgtgcca ggcactgctg ggaaagacag     2460



aataaactat aaacctggtg ttgaggctac                                      2490





<210>  219

<211>  438

<212>  PRT

<213>  Homo sapiens



<400>  219



Met Ser Pro Lys Arg Ile Ala Lys Arg Arg Ser Pro Pro Ala Asp Ala 

1               5                   10                  15      





Ile Pro Lys Ser Lys Lys Val Lys Asp Thr Arg Ala Ala Ala Ser Arg 

            20                  25                  30          





Arg Val Pro Gly Ala Arg Ser Cys Gln Val Ser His Arg Ser His Ser 

        35                  40                  45              





Thr Glu Pro Gly Leu Val Leu Thr Leu Gly Gln Gly Asp Val Gly Gln 

    50                  55                  60                  





Leu Gly Leu Gly Glu Asn Val Met Glu Arg Lys Lys Pro Ala Leu Val 

65                  70                  75                  80  





Ser Ile Pro Glu Asp Val Val Gln Ala Glu Ala Gly Gly Met His Thr 

                85                  90                  95      





Val Cys Leu Ser Lys Ser Gly Gln Val Tyr Ser Phe Gly Cys Asn Asp 

            100                 105                 110         





Glu Gly Ala Leu Gly Arg Asp Thr Ser Val Glu Gly Ser Glu Met Val 

        115                 120                 125             





Pro Gly Lys Val Glu Leu Gln Glu Lys Val Val Gln Val Ser Ala Gly 

    130                 135                 140                 





Asp Ser His Thr Ala Ala Leu Thr Asp Asp Gly Arg Val Phe Leu Trp 

145                 150                 155                 160 





Gly Ser Phe Arg Asp Asn Asn Gly Val Ile Gly Leu Leu Glu Pro Met 

                165                 170                 175     





Lys Lys Ser Met Val Pro Val Gln Val Gln Leu Asp Val Pro Val Val 

            180                 185                 190         





Lys Val Ala Ser Gly Asn Asp His Leu Val Met Leu Thr Ala Asp Gly 

        195                 200                 205             





Asp Leu Tyr Thr Leu Gly Cys Gly Glu Gln Gly Gln Leu Gly Arg Val 

    210                 215                 220                 





Pro Glu Leu Phe Ala Asn Arg Gly Gly Arg Gln Gly Leu Glu Arg Leu 

225                 230                 235                 240 





Leu Val Pro Lys Cys Val Met Leu Lys Ser Arg Gly Ser Arg Gly His 

                245                 250                 255     





Val Arg Phe Gln Asp Ala Phe Cys Gly Ala Tyr Phe Thr Phe Ala Ile 

            260                 265                 270         





Ser His Glu Gly His Val Tyr Gly Phe Gly Leu Ser Asn Tyr His Gln 

        275                 280                 285             





Leu Gly Thr Pro Gly Thr Glu Ser Cys Phe Ile Pro Gln Asn Leu Thr 

    290                 295                 300                 





Ser Phe Lys Asn Ser Thr Lys Ser Trp Val Gly Phe Ser Gly Gly Gln 

305                 310                 315                 320 





His His Thr Val Cys Met Asp Ser Glu Gly Lys Ala Tyr Ser Leu Gly 

                325                 330                 335     





Arg Ala Glu Tyr Gly Arg Leu Gly Leu Gly Glu Gly Ala Glu Glu Lys 

            340                 345                 350         





Ser Ile Pro Thr Leu Ile Ser Arg Leu Pro Ala Val Ser Ser Val Ala 

        355                 360                 365             





Cys Gly Ala Ser Val Gly Tyr Ala Val Thr Lys Asp Gly Arg Val Phe 

    370                 375                 380                 





Ala Trp Gly Met Gly Thr Asn Tyr Gln Leu Gly Thr Gly Gln Asp Glu 

385                 390                 395                 400 





Asp Ala Trp Ser Pro Val Glu Met Met Gly Lys Gln Leu Glu Asn Arg 

                405                 410                 415     





Val Val Leu Ser Val Ser Ser Gly Gly Gln His Thr Val Leu Leu Val 

            420                 425                 430         





Lys Asp Lys Glu Gln Ser 

        435             





<210>  220

<211>  2439

<212>  DNA

<213>  Homo sapiens



<400>  220

tgcagagcgc atgctctggg gcagttcgcg gcccggcggg gagcgccgga gttccttgtg       60



gccgacgtgc accaaggaca ggaagatgtc acccaagcgc atagctaaaa gaaggtcccc      120



cccagcagat gccatcccca aaagcaagaa ggtgaaggtc tcacacaggt cccacagcac      180



agaacccggc ttggtgctga cactaggcca gggcgacgtg ggccagctgg ggctgggtga      240



gaatgtgatg gagaggaaga agccggccct ggtatccatt ccggaggatg ttgtgcaggc      300



tgaggctggg ggcatgcaca ccgtgtgtct aagcaaaagt ggccaggtct attccttcgg      360



ctgcaatgat gagggtgccc tgggaaggga cacatcagtg gagggctcgg agatggtccc      420



tgggaaagtg gagctgcaag agaaggtggt acaggtgtca gcaggagaca gtcacacagc      480



agccctcacc gatgatggcc gtgtcttcct ctggggctcc ttccgggaca ataacggtgt      540



gattggactg ttggagccca tgaagaagag catggtgcct gtgcaggtgc agctggatgt      600



gcctgtggta aaggtggcct caggaaacga ccacttggtg atgctgacag ctgatggtga      660



cctctacacc ttgggctgcg gggaacaggg ccagctaggc cgtgtgcctg agttatttgc      720



caaccgtggt ggccggcaag gcctcgaacg actcctggtc cccaagtgtg tgatgctgaa      780



atccagggga agccggggcc acgtgagatt ccaggatgcc ttttgtggtg cctatttcac      840



ctttgccatc tcccatgagg gccacgtgta cggcttcggc ctctccaact accatcagct      900



tggaactccg ggcacagaat cttgcttcat accccagaac ctaacatcct tcaagaattc      960



caccaagtcc tgggtgggct tctctggtgg ccagcaccat acagtctgca tggattcgga     1020



aggaaaagca tacagcctgg gccgggctga gtatgggcgg ctgggccttg gagagggtgc     1080



tgaggagaag agcataccca ccctcatctc caggctgcct gctgtctcct cggtggcttg     1140



tggggcctct gtggggtatg ctgtgaccaa ggatggtcgt gttttcgcct ggggcatggg     1200



caccaactac cagctgggca cagggcagga tgaggacgcc tggagccctg tggagatgat     1260



gggcaaacag ctggagaacc gtgtggtctt atctgtgtcc agcgggggcc agcatacagt     1320



cttattagtc aaggacaaag aacagagctg atgaagcctc tgagggcctg gcttctgtcc     1380



tgcacaacct ccctcacaga acagggaagc agtgacagct gcagatggca gcgggcctct     1440



ccccagccct gagcactgtg tcagttcctg ccttttctca tcagcagaac agaatccttt     1500



tcctcttttc cttcctcctc tttggaattt tcctgggacc tacagaataa agggggggat     1560



ggacaggggg ttttcaaaag gaacatggct cactcagagc tatatggtta gacgtttctc     1620



cccttttccc taccttccat ggtcctggtt ggccctggct ttgcctacta gaaaaccaaa     1680



acttcccccc tggggttttg tgcccactct ctgagaagtt ggggctccat caagccccat     1740



tctagtcatg tgcccctttc ctgtccctaa cagtccacag gcaaacaaat ggtacagtca     1800



taagagccat ctgtcacgga cccacgccca gaggaacgtg cagaaaaaag cagagctaca     1860



tggctgtggg caactataag ccaaatattt ggctcagaac aggtgtccat gggacaaaaa     1920



agaacgatcc tccacttgac caagaaaaaa gtgattctcc cagaagcaca aagcatactc     1980



ttgcccctca ggtgttgctt gtgtacatcg tacccatcca ttcggcttca cctgcagcca     2040



acggcctgga atcgcaaaga gacaccactc tgggcagagc agagcagggt atggggtggg     2100



gagagagggt ggagggtttt ataaacaaac ttaacagcaa tattgaaagg aggtggggga     2160



ttgagggagg gacagagtgt tggagggcca gagactagtc ctgagatgga aacagcaact     2220



tgtacagtgg ctgagaaaat aggatatagt tttgattttt ttaattgtaa aatattttgg     2280



agggagaaca aaatctttta acattttgaa taaatttaga gttttataaa ataggccact     2340



tgttttctac acattccctg ctttttaagg gagcacatat tatgtgccag gcactgctgg     2400



gaaagacaga ataaactata aacctggtgt tgaggctac                            2439





<210>  221

<211>  421

<212>  PRT

<213>  Homo sapiens



<400>  221



Met Ser Pro Lys Arg Ile Ala Lys Arg Arg Ser Pro Pro Ala Asp Ala 

1               5                   10                  15      





Ile Pro Lys Ser Lys Lys Val Lys Val Ser His Arg Ser His Ser Thr 

            20                  25                  30          





Glu Pro Gly Leu Val Leu Thr Leu Gly Gln Gly Asp Val Gly Gln Leu 

        35                  40                  45              





Gly Leu Gly Glu Asn Val Met Glu Arg Lys Lys Pro Ala Leu Val Ser 

    50                  55                  60                  





Ile Pro Glu Asp Val Val Gln Ala Glu Ala Gly Gly Met His Thr Val 

65                  70                  75                  80  





Cys Leu Ser Lys Ser Gly Gln Val Tyr Ser Phe Gly Cys Asn Asp Glu 

                85                  90                  95      





Gly Ala Leu Gly Arg Asp Thr Ser Val Glu Gly Ser Glu Met Val Pro 

            100                 105                 110         





Gly Lys Val Glu Leu Gln Glu Lys Val Val Gln Val Ser Ala Gly Asp 

        115                 120                 125             





Ser His Thr Ala Ala Leu Thr Asp Asp Gly Arg Val Phe Leu Trp Gly 

    130                 135                 140                 





Ser Phe Arg Asp Asn Asn Gly Val Ile Gly Leu Leu Glu Pro Met Lys 

145                 150                 155                 160 





Lys Ser Met Val Pro Val Gln Val Gln Leu Asp Val Pro Val Val Lys 

                165                 170                 175     





Val Ala Ser Gly Asn Asp His Leu Val Met Leu Thr Ala Asp Gly Asp 

            180                 185                 190         





Leu Tyr Thr Leu Gly Cys Gly Glu Gln Gly Gln Leu Gly Arg Val Pro 

        195                 200                 205             





Glu Leu Phe Ala Asn Arg Gly Gly Arg Gln Gly Leu Glu Arg Leu Leu 

    210                 215                 220                 





Val Pro Lys Cys Val Met Leu Lys Ser Arg Gly Ser Arg Gly His Val 

225                 230                 235                 240 





Arg Phe Gln Asp Ala Phe Cys Gly Ala Tyr Phe Thr Phe Ala Ile Ser 

                245                 250                 255     





His Glu Gly His Val Tyr Gly Phe Gly Leu Ser Asn Tyr His Gln Leu 

            260                 265                 270         





Gly Thr Pro Gly Thr Glu Ser Cys Phe Ile Pro Gln Asn Leu Thr Ser 

        275                 280                 285             





Phe Lys Asn Ser Thr Lys Ser Trp Val Gly Phe Ser Gly Gly Gln His 

    290                 295                 300                 





His Thr Val Cys Met Asp Ser Glu Gly Lys Ala Tyr Ser Leu Gly Arg 

305                 310                 315                 320 





Ala Glu Tyr Gly Arg Leu Gly Leu Gly Glu Gly Ala Glu Glu Lys Ser 

                325                 330                 335     





Ile Pro Thr Leu Ile Ser Arg Leu Pro Ala Val Ser Ser Val Ala Cys 

            340                 345                 350         





Gly Ala Ser Val Gly Tyr Ala Val Thr Lys Asp Gly Arg Val Phe Ala 

        355                 360                 365             





Trp Gly Met Gly Thr Asn Tyr Gln Leu Gly Thr Gly Gln Asp Glu Asp 

    370                 375                 380                 





Ala Trp Ser Pro Val Glu Met Met Gly Lys Gln Leu Glu Asn Arg Val 

385                 390                 395                 400 





Val Leu Ser Val Ser Ser Gly Gly Gln His Thr Val Leu Leu Val Lys 

                405                 410                 415     





Asp Lys Glu Gln Ser 

            420     





<210>  222

<211>  1613

<212>  DNA

<213>  Homo sapiens



<400>  222

ggtggcggga agaggaggcg cgagaatgga ggtggaggcc gtctgtggtg gcgcgggcga       60



ggtggaggcc caggactctg accctgcccc tgccttcagc aaggcccccg gcagcgccgg      120



ccactacgaa ctgccgtggg ttgaaaaata taggccagta aagctgaatg aaattgtcgg      180



gaatgaagac accgtgagca ggctagaggt ctttgcaagg gaaggaaatg tgcccaacat      240



catcattgcg ggccctccag gaaccggcaa gaccacaagc attctgtgct tggcccgggc      300



cctgctgggc ccagcactca aagatgccat gttggaactc aatgcttcaa atgacagcat      360



gaccgacgga gcccagcaag ccttgaggag aaccatggaa atctactcta aaaccactcg      420



cttcgccctt gcttgtaatg cttcggataa gatcatcgag cccattcagt cccgctgtgc      480



agtcctccgg tacacaaagc tgaccgacgc ccagatcctc accaggctga tgaatgttat      540



cgagaaggag agggtaccct acactgatga cggcctagaa gccatcatct tcacggccca      600



gggagacatg aggcaggcgc tgaacaacct gcagtccacc ttctcaggat ttggcttcat      660



taacagtgag aacgtgttca aggtctgtga cgagccccac ccactgctgg taaaggagat      720



gatccagcac tgtgtgaatg ccaacattga cgaagcctac aagattcttg ctcacttgtg      780



gcatctgggc tactcaccag aagatatcat tggcaacatc tttcgagtgt gtaaaacttt      840



ccaaatggca gaatacctga aactggagtt tatcaaggaa attggataca ctcacatgaa      900



aatagcggaa ggagtgaact ctcttttgca gatggcaggc ctcctggcaa ggctgtgtca      960



gaagacaatg gccccggtgg ccagttagag cagagacttc actgactgac ttacaggtgc     1020



cctattctga ggtacaggag ccgcggcttt ctgatggggg aaaatgccgc cttaggctgg     1080



agccaacatg actgtccttt aaactccagt ggctggccag gcacggtagc tcacgcctgt     1140



aatcccaaca ctttgggagg ccgaggcagg tggatcacct gaggtcagaa gttcaagacc     1200



agcctggcca acatggggaa accctgtctt tactaaaaat ataaaaatta gctgggtgtg     1260



gtggcgggca cctgtaatcc cagctactcg ggaggctgtg gcaggagaat cgcttgaacc     1320



caggaggtgg aggttgcagt gagccaagat cacaccattg cactccagcc tgggcgacag     1380



agtctccatc tggggaaaaa aattaaataa ataaactccc gtgacttgca tgtttgcttc     1440



tgggacgtct gtgccccgca agtgtttgag tttggcctcc accccattga tgcggtgacg     1500



gggcggaaag gcgcagagaa gctgagggcg gtctctgatc tgtgtgtggg ttgacatttt     1560



agctaataaa gccttgcagt gtttgttggc aaaaaaaaaa aaaaaaaaaa aaa            1613





<210>  223

<211>  320

<212>  PRT

<213>  Homo sapiens



<400>  223



Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 

1               5                   10                  15      





Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 

            20                  25                  30          





His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 

        35                  40                  45              





Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 

    50                  55                  60                  





Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 

65                  70                  75                  80  





Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 

                85                  90                  95      





Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Ser Met 

            100                 105                 110         





Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser 

        115                 120                 125             





Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile 

    130                 135                 140                 





Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr 

145                 150                 155                 160 





Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg 

                165                 170                 175     





Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln 

            180                 185                 190         





Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly 

        195                 200                 205             





Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro 

    210                 215                 220                 





His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn Ala Asn 

225                 230                 235                 240 





Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr 

                245                 250                 255     





Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe 

            260                 265                 270         





Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr 

        275                 280                 285             





Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala 

    290                 295                 300                 





Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 

305                 310                 315                 320 





<210>  224

<211>  1715

<212>  DNA

<213>  Homo sapiens



<400>  224

ggtggcggga agaggaggcg cgagaatgga ggtggaggcc gtctgtggtg gcgcgggcga       60



ggtggaggcc caggactctg accctgcccc tgccttcagc aaggcccccg gcagcgccgg      120



ccactacgaa ctgccgtggg ttgaaaaata taggccagta aagctgaatg aaattgtcgg      180



gaatgaagac accgtgagca ggctagaggt ctttgcaagg gaaggaaatg tgcccaacat      240



catcattgcg ggccctccag gaaccggcaa gaccacaagc attctgtgct tggcccgggc      300



cctgctgggc ccagcactca aagatgccat gttggaactc aatgcttcaa atgacagggg      360



cattgacgtt gtgaggaata aaattaaaat gtttgctcaa caaaaagtca ctcttcccaa      420



aggccgacat aagatcatca ttctggatga agcagacagc atgaccgacg gagcccagca      480



agccttgagg agaaccatgg aaatctactc taaaaccact cgcttcgccc ttgcttgtaa      540



tgcttcggat aagatcatcg agcccattca gtcccgctgt gcagtcctcc ggtacacaaa      600



gctgaccgac gcccagatcc tcaccaggct gatgaatgtt atcgagaagg agagggtacc      660



ctacactgat gacggcctag aagccatcat cttcacggcc cagggagaca tgaggcaggc      720



gctgaacaac ctgcagtcca ccttctcagg atttggcttc attaacagtg agaacgtgtt      780



caaggtctgt gacgagcccc acccactgct ggtaaaggag atgatccagc actgtgtgaa      840



tgccaacatt gacgaagcct acaagattct tgctcacttg tggcatctgg gctactcacc      900



agaagatatc attggcaaca tctttcgagt gtgtaaaact ttccaaatgg cagaatacct      960



gaaactggag tttatcaagg aaattggata cactcacatg aaaatagcgg aaggagtgaa     1020



ctctcttttg cagatggcag gcctcctggc aaggctgtgt cagaagacaa tggccccggt     1080



ggccagttag agcagagact tcactgactg acttacaggt gccctattct gaggtacagg     1140



agccgcggct ttctgatggg ggaaaatgcc gccttaggct ggagccaaca tgactgtcct     1200



ttaaactcca gtggctggcc aggcacggta gctcacgcct gtaatcccaa cactttggga     1260



ggccgaggca ggtggatcac ctgaggtcag aagttcaaga ccagcctggc caacatgggg     1320



aaaccctgtc tttactaaaa atataaaaat tagctgggtg tggtggcggg cacctgtaat     1380



cccagctact cgggaggctg tggcaggaga atcgcttgaa cccaggaggt ggaggttgca     1440



gtgagccaag atcacaccat tgcactccag cctgggcgac agagtctcca tctggggaaa     1500



aaaattaaat aaataaactc ccgtgacttg catgtttgct tctgggacgt ctgtgccccg     1560



caagtgtttg agtttggcct ccaccccatt gatgcggtga cggggcggaa aggcgcagag     1620



aagctgaggg cggtctctga tctgtgtgtg ggttgacatt ttagctaata aagccttgca     1680



gtgtttgttg gcaaaaaaaa aaaaaaaaaa aaaaa                                1715





<210>  225

<211>  354

<212>  PRT

<213>  Homo sapiens



<400>  225



Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 

1               5                   10                  15      





Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 

            20                  25                  30          





His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 

        35                  40                  45              





Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 

    50                  55                  60                  





Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 

65                  70                  75                  80  





Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 

                85                  90                  95      





Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly 

            100                 105                 110         





Ile Asp Val Val Arg Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val 

        115                 120                 125             





Thr Leu Pro Lys Gly Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp 

    130                 135                 140                 





Ser Met Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile 

145                 150                 155                 160 





Tyr Ser Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys 

                165                 170                 175     





Ile Ile Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys 

            180                 185                 190         





Leu Thr Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys 

        195                 200                 205             





Glu Arg Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr 

    210                 215                 220                 





Ala Gln Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe 

225                 230                 235                 240 





Ser Gly Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp 

                245                 250                 255     





Glu Pro His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn 

            260                 265                 270         





Ala Asn Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu 

        275                 280                 285             





Gly Tyr Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys 

    290                 295                 300                 





Thr Phe Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile 

305                 310                 315                 320 





Gly Tyr Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln 

                325                 330                 335     





Met Ala Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val 

            340                 345                 350         





Ala Ser 

        





<210>  226

<211>  942

<212>  DNA

<213>  Homo sapiens



<400>  226

tacgaatctc gcgagaagtc aagttctcat gagttctccc aaaatccacc gctcttcctc       60



tttccctaag cagcctgagg gttgactgga ttggtgaggc ccgtgtggct acttctgtgg      120



aagcagtgct gtagttactg gaagataaaa gggaaagcaa gcccttggtg ggggaaagta      180



tggctgcgat gatggcattt cttaggacac ctttggatta ataatgaaaa caactactct      240



ctgagcagct gttcgaatca tctgatattt atactgaatg agttactgta agtacgtatt      300



gacagaatta cactgtactt tcctctaggt gatctgtgaa aatggttcgc tattcacttg      360



acccggagaa ccccacgaaa tcatgcaaat caagaggttc caatcttcgt gttcacttta      420



agaacactcg tgaaactgct caggccatca agggtatgca tatacgaaaa gccacgaagt      480



atctgaaaga tgtcacttta cagaaacagt gtgtaccatt ccgacgttac aatggtggag      540



ttggcaggtg tgcgcaggcc aagcaatggg gctggacaca aggtcggtgg cccaaaaaga      600



gtgctgaatt tttgctgcac atgcttaaaa acgcagagag taatgctgaa cttaagggtt      660



tagatgtaga ttctctggtc attgagcata tccaagtgaa caaagcacct aagatgcgcc      720



gccggaccta cagagctcat ggtcggatta acccatacat gagctctccc tgccacattg      780



agatgatcct tacggaaaag gaacagattg ttcctaaacc agaagaggag gttgcccaga      840



agaaaaagat atcccagaag aaactgaaga aacaaaaact tatggcacgg gagtaaattc      900



agcattaaaa taaatgtaat taaaaggaaa aaaaaaaaaa aa                         942





<210>  227

<211>  184

<212>  PRT

<213>  Homo sapiens



<400>  227



Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys Ser Cys Lys 

1               5                   10                  15      





Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr Arg Glu Thr 

            20                  25                  30          





Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr Lys Tyr Leu 

        35                  40                  45              





Lys Asp Val Thr Leu Gln Lys Gln Cys Val Pro Phe Arg Arg Tyr Asn 

    50                  55                  60                  





Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly Trp Thr Gln 

65                  70                  75                  80  





Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His Met Leu Lys 

                85                  90                  95      





Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val Asp Ser Leu 

            100                 105                 110         





Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met Arg Arg Arg 

        115                 120                 125             





Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser Ser Pro Cys 

    130                 135                 140                 





His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val Pro Lys Pro 

145                 150                 155                 160 





Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys Lys Leu Lys 

                165                 170                 175     





Lys Gln Lys Leu Met Ala Arg Glu 

            180                 





<210>  228

<211>  693

<212>  DNA

<213>  Homo sapiens



<400>  228

tacgaatctc gcgagaagtc aagttctcat gagttctccc aaaatccacc gctcttcctc       60



tttccctaag cagcctgagg tgatctgtga aaatggttcg ctattcactt gacccggaga      120



accccacgaa atcatgcaaa tcaagaggtt ccaatcttcg tgttcacttt aagaacactc      180



gtgaaactgc tcaggccatc aagggtatgc atatacgaaa agccacgaag tatctgaaag      240



atgtcacttt acagaaacag tgtgtaccat tccgacgtta caatggtgga gttggcaggt      300



gtgcgcaggc caagcaatgg ggctggacac aaggtcggtg gcccaaaaag agtgctgaat      360



ttttgctgca catgcttaaa aacgcagaga gtaatgctga acttaagggt ttagatgtag      420



attctctggt cattgagcat atccaagtga acaaagcacc taagatgcgc cgccggacct      480



acagagctca tggtcggatt aacccataca tgagctctcc ctgccacatt gagatgatcc      540



ttacggaaaa ggaacagatt gttcctaaac cagaagagga ggttgcccag aagaaaaaga      600



tatcccagaa gaaactgaag aaacaaaaac ttatggcacg ggagtaaatt cagcattaaa      660



ataaatgtaa ttaaaaggaa aaaaaaaaaa aaa                                   693





<210>  229

<211>  593

<212>  DNA

<213>  Homo sapiens



<400>  229

acccggcgct ccattaaata gccgtagacg gaacttcgcc tttctctcgg ccttagcgcc       60



atttttttgg gtgagtgttt tttggttcct gcgttgggat tccgtgtaca atccatagac      120



atctgacctc ggcacttagc atcatcacag caaactaact gtagcctttc tctctttccc      180



tgtagaaacc tctgcgccat gagagccaag tggaggaaga agcgaatgcg caggctgaag      240



cgcaaaagaa gaaagatgag gcagaggtcc aagtaaaccg ctagcttgtt gcaccgtgga      300



ggccacagga gcagaaacat ggaatgccag acgctgggga tgctggtaca agttgtggga      360



ctgcatgcta ctgtctagag cttgtctcaa tggatctaga acttcatcgc cctctgatcg      420



ccgatcacct ctgagaccca ccttgctcat aaacaaaatg cccatgttgg tcctctgccc      480



tggacctgtg acattctgga ctatttctgt gtttatttgt ggccgagtgt aacaaccata      540



taataaatca cctcttccgc tgttttagct gaagaattaa atcaaaaaaa aaa             593





<210>  230

<211>  25

<212>  PRT

<213>  Homo sapiens



<400>  230



Met Arg Ala Lys Trp Arg Lys Lys Arg Met Arg Arg Leu Lys Arg Lys 

1               5                   10                  15      





Arg Arg Lys Met Arg Gln Arg Ser Lys 

            20                  25  





<210>  231

<211>  478

<212>  DNA

<213>  Homo sapiens



<400>  231

acccggcgct ccattaaata gccgtagacg gaacttcgcc tttctctcgg ccttagcgcc       60



atttttttgg aaacctctgc gccatgagag ccaagtggag gaagaagcga atgcgcaggc      120



tgaagcgcaa aagaagaaag atgaggcaga ggtccaagta aaccgctagc ttgttgcacc      180



gtggaggcca caggagcaga aacatggaat gccagacgct ggggatgctg gtacaagttg      240



tgggactgca tgctactgtc tagagcttgt ctcaatggat ctagaacttc atcgccctct      300



gatcgccgat cacctctgag acccaccttg ctcataaaca aaatgcccat gttggtcctc      360



tgccctggac ctgtgacatt ctggactatt tctgtgttta tttgtggccg agtgtaacaa      420



ccatataata aatcacctct tccgctgttt tagctgaaga attaaatcaa aaaaaaaa        478





<210>  232

<211>  25

<212>  PRT

<213>  Homo sapiens



<400>  232



Met Arg Ala Lys Trp Arg Lys Lys Arg Met Arg Arg Leu Lys Arg Lys 

1               5                   10                  15      





Arg Arg Lys Met Arg Gln Arg Ser Lys 

            20                  25  





<210>  233

<211>  751

<212>  DNA

<213>  Homo sapiens



<400>  233

aaagcattcc gaaggctaaa gtgagaaata agcccaggct agggagagga gaaacgaagt       60



tcacgtccta gtctggcacc gggttggatt gtcgctggga cggcagtcag gcatttggtg      120



tggtcgccta aggggtgggt ccttcggcgg gagctccggg aaaccccgtg ggcctgcgcg      180



gcgttcttcc ttttcgatcc gccatctgcg gtggagccgc caccaaaatg cagattttcg      240



tgaaaaccct tacggggaag accatcaccc tcgaggttga accctcggat acgatagaaa      300



atgtaaaggc caagatccag gataaggaag gaattcctcc tgatcagcag agactgatct      360



ttgctggcaa gcagctggaa gatggacgta ctttgtctga ctacaatatt caaaaggagt      420



ctactcttca tcttgtgttg agacttcgtg gtggtgctaa gaaaaggaag aagaagtctt      480



acaccactcc caagaagaat aagcacaaga gaaagaaggt taagctggct gtcctgaaat      540



attataaggt ggatgagaat ggcaaaatta gtcgccttcg tcgagagtgc ccttctgatg      600



aatgtggtgc tggggtgttt atggcaagtc actttgacag acattattgt ggcaaatgtt      660



gtctgactta ctgtttcaac aaaccagaag acaagtaact gtatgagtta ataaaagaca      720



tgaactaaca tttaaaaaaa aaaaaaaaaa a                                     751





<210>  234

<211>  156

<212>  PRT

<213>  Homo sapiens



<400>  234



Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 

1               5                   10                  15      





Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 

            20                  25                  30          





Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 

        35                  40                  45              





Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 

    50                  55                  60                  





Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ala Lys Lys Arg 

65                  70                  75                  80  





Lys Lys Lys Ser Tyr Thr Thr Pro Lys Lys Asn Lys His Lys Arg Lys 

                85                  90                  95      





Lys Val Lys Leu Ala Val Leu Lys Tyr Tyr Lys Val Asp Glu Asn Gly 

            100                 105                 110         





Lys Ile Ser Arg Leu Arg Arg Glu Cys Pro Ser Asp Glu Cys Gly Ala 

        115                 120                 125             





Gly Val Phe Met Ala Ser His Phe Asp Arg His Tyr Cys Gly Lys Cys 

    130                 135                 140                 





Cys Leu Thr Tyr Cys Phe Asn Lys Pro Glu Asp Lys 

145                 150                 155     





<210>  235

<211>  3031

<212>  DNA

<213>  Homo sapiens



<400>  235

gtggtagcgg ttattcggcg gcccgcggcg gaccatggcc ctggccctgg cccggcgtcg       60



ctgggctttc ctcacggcgt ccccgagcag cgtcgcagag cgggccgact tccgggaagg      120



aactgaccag cgactgagcg gcggccggcg cgcttagcgc cctgaacatg cggcagtccc      180



tgcgggcgac cccgggctcc ggacaggcgg cggcggaggc ggcggctcgg gagggaagga      240



ggcggcggcg ccggcggagg tggcggcgga gacggccggc gcccggcgcg gagccctagg      300



gaggcagttc agcgcggcct cgggcctcgt cgagaaggat gctgtcccga aagaaaacca      360



aaaacgaagt gtccaagccg gccgaggtgc aggggaagta cgtgaagaag gagacgtcgc      420



ctctgcttcg gaatcttatg ccttcattca tccggcatgg tccaacaatt ccaagacgaa      480



ctgatatctg tcttccagat tcaagcccta atgccttttc aacttctgga gatgtagttt      540



caagaaacca gagtttcctt agaactccaa ttcaaagaac acctcatgaa ataatgagaa      600



gagaaagcaa cagattatct gcaccttctt atcttgccag aagtctagca gatgtcccta      660



gagagtatgg ttcttctcag tcatttgtaa cggaagttag ttttgctgtt gaaaatggag      720



actctggttc ccgatattat tattcagaca atttttttga tggtcagaga aagcggccac      780



ttggagatcg tgcacatgaa gactacagat attatgaata caaccatgat ctcttccaaa      840



gaatgccaca gaatcagggg aggcatgctt caggtattgg gagagttgct gctacatctt      900



taggaaattt gactaaccat ggttctgaag atttacccct tcctcctggc tggtctgtgg      960



actggacaat gagagggaga aaatattata tagatcataa cacaaataca actcactgga     1020



gccatcctct tgagcgagaa ggacttcctc ctggatggga acgagttgag tcatccgaat     1080



ttggaaccta ttatgtagat cacacaaata agaaggccca atacaggcat ccctgtgctc     1140



ctagtgtacc tcggtatgat caaccacctc ctgtcacata ccagccacag caaactgaaa     1200



gaaatcagtc ccttctggta cctgcaaatc catatcatac tgcagaaatt cctgactggc     1260



ttcaggttta cgcacgagcc cctgtgaaat atgaccacat tctgaagtgg gaactcttcc     1320



agctggctga cctggataca taccagggaa tgctaaagtt gctcttcatg aaagaattgg     1380



agcagattgt taaaatgtat gaagcataca gacaagccct tcttacagag ttggaaaacc     1440



gaaagcagag acagcagtgg tatgcccaac aacatggaaa aaatttttga gctgattttt     1500



taaaaattta agttttgtaa gagctttaaa atattttcac agataaaaaa ttgcaaacaa     1560



gtactctggt taataaatgc tgcttccttt gtggaaatta taaaattcta actttacatg     1620



tattttgtta ttagaaattt tcttttattg aatgagaaaa attagtctat cattttaaga     1680



gccaatatgg caaacacttt caaatactgt atattaggaa actgttttgg tattcttgat     1740



ggaaaaaaac gcagcggaaa tgtcattatg aacagatgtt aaataggaaa ttattacttg     1800



ttaacttctt acagcagtag taccttcttt aaaaaaaaaa aagaatctgc ggtatttttt     1860



taaaaaaaaa gtttaccgct gtagtgtgaa atattgtctg gaaagggatg gtttaaatat     1920



taccatgatg tagttgaaat ataaaatagg atttggaacc ttattgtgat aaatatttat     1980



atatgatgta tgtttgtctc ccctctccaa agtaaggaac ccagctgggc gtggtggctc     2040



actcctgtaa tcccagcatt ttgggaggcc gaggtgggtg gaccgcttga gtccacgagt     2100



ttaagaccag cctgggcaac atggtgaagc cccatctcta caaaaaatac aaaaaaatta     2160



gccgggtatg atggtgtgtg cctctagtcc cagctacttg ggaggctgag gtcagaggat     2220



ggcttgagcc caagaggcag aggttgcagg gtcaagatcg caccacttgc actgcagcct     2280



gagagagaga gagccagacc ttgtctcaaa aaataaaaaa taaaaaaata aaaacaaaat     2340



aaggaatcct tttaaagcat gttgagaaag tattttttgg tatgaatggg tgacgggcct     2400



tttaatcttt caggaataca tataagcagg aatacttagc ctgtattggg aaggtgcgtg     2460



aaactcaaag ttgctaacat catcttcctt attttcagcc agtgctgtta ctgcatttag     2520



catggctctg acgaggcagt ggagagttcc tgacagcata gcatactgcc ttctgacaga     2580



ctgggttaag ctaccaaaaa tgacaaccag ggattcaaaa aaaatttttg gtcattaaat     2640



cgaatgtata ttattacttt ttaattttct aagtatttat cacaggactt taacaccata     2700



tatttccctc ccagtttttc tccccttttg gtttaatagt taaaacattt ttcataatta     2760



gtgctgtaca tttgattgca aacaaattgg tgatacttct aaactataac tataaatctc     2820



tagaattctg tgaatttcaa cattatttga agtagttctt cagttatatt tacatgtgtt     2880



gtaaatatgt aaatatactt ttagcttagg aagtcttcca gaatacaaac tactcccagt     2940



tagatatcag tgagtttgaa taactgaaga aatgttgaca atgttaagtg tttgatttta     3000



tataacaagc ttattaaata tatttttgtg g                                    3031





<210>  236

<211>  383

<212>  PRT

<213>  Homo sapiens



<400>  236



Met Leu Ser Arg Lys Lys Thr Lys Asn Glu Val Ser Lys Pro Ala Glu 

1               5                   10                  15      





Val Gln Gly Lys Tyr Val Lys Lys Glu Thr Ser Pro Leu Leu Arg Asn 

            20                  25                  30          





Leu Met Pro Ser Phe Ile Arg His Gly Pro Thr Ile Pro Arg Arg Thr 

        35                  40                  45              





Asp Ile Cys Leu Pro Asp Ser Ser Pro Asn Ala Phe Ser Thr Ser Gly 

    50                  55                  60                  





Asp Val Val Ser Arg Asn Gln Ser Phe Leu Arg Thr Pro Ile Gln Arg 

65                  70                  75                  80  





Thr Pro His Glu Ile Met Arg Arg Glu Ser Asn Arg Leu Ser Ala Pro 

                85                  90                  95      





Ser Tyr Leu Ala Arg Ser Leu Ala Asp Val Pro Arg Glu Tyr Gly Ser 

            100                 105                 110         





Ser Gln Ser Phe Val Thr Glu Val Ser Phe Ala Val Glu Asn Gly Asp 

        115                 120                 125             





Ser Gly Ser Arg Tyr Tyr Tyr Ser Asp Asn Phe Phe Asp Gly Gln Arg 

    130                 135                 140                 





Lys Arg Pro Leu Gly Asp Arg Ala His Glu Asp Tyr Arg Tyr Tyr Glu 

145                 150                 155                 160 





Tyr Asn His Asp Leu Phe Gln Arg Met Pro Gln Asn Gln Gly Arg His 

                165                 170                 175     





Ala Ser Gly Ile Gly Arg Val Ala Ala Thr Ser Leu Gly Asn Leu Thr 

            180                 185                 190         





Asn His Gly Ser Glu Asp Leu Pro Leu Pro Pro Gly Trp Ser Val Asp 

        195                 200                 205             





Trp Thr Met Arg Gly Arg Lys Tyr Tyr Ile Asp His Asn Thr Asn Thr 

    210                 215                 220                 





Thr His Trp Ser His Pro Leu Glu Arg Glu Gly Leu Pro Pro Gly Trp 

225                 230                 235                 240 





Glu Arg Val Glu Ser Ser Glu Phe Gly Thr Tyr Tyr Val Asp His Thr 

                245                 250                 255     





Asn Lys Lys Ala Gln Tyr Arg His Pro Cys Ala Pro Ser Val Pro Arg 

            260                 265                 270         





Tyr Asp Gln Pro Pro Pro Val Thr Tyr Gln Pro Gln Gln Thr Glu Arg 

        275                 280                 285             





Asn Gln Ser Leu Leu Val Pro Ala Asn Pro Tyr His Thr Ala Glu Ile 

    290                 295                 300                 





Pro Asp Trp Leu Gln Val Tyr Ala Arg Ala Pro Val Lys Tyr Asp His 

305                 310                 315                 320 





Ile Leu Lys Trp Glu Leu Phe Gln Leu Ala Asp Leu Asp Thr Tyr Gln 

                325                 330                 335     





Gly Met Leu Lys Leu Leu Phe Met Lys Glu Leu Glu Gln Ile Val Lys 

            340                 345                 350         





Met Tyr Glu Ala Tyr Arg Gln Ala Leu Leu Thr Glu Leu Glu Asn Arg 

        355                 360                 365             





Lys Gln Arg Gln Gln Trp Tyr Ala Gln Gln His Gly Lys Asn Phe 

    370                 375                 380             





<210>  237

<211>  2408

<212>  DNA

<213>  Homo sapiens



<400>  237

cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg       60



accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc      120



ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg      180



ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc      240



ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg      300



ctggtgtcca gggtctcagc gcgggggacg actcagagtt ggggtctcac tgtgttgccc      360



agactggtct cgaactcttg gcctcaggtg atcctcttcc ctcagcttcc cagaatgccg      420



agatgataga gacggggtct gactgtgtta cccaggctgg tcttcaactc ttggcctcaa      480



gtgatcctcc tgccttagct tccaagaatg ctgaggttac agaaacgggg tttcaccatg      540



ttagccaggc tgatattgaa ttcctgacct caattgatcc gactgcctcg gcctccggaa      600



gtgctgggat tacaggcacc atgagccagg acaccgaggt ggatatgaag gaggtggagc      660



tgaatgagtt agagcccgag aagcagccga tgaacgcggc gtctggggcg gccatgtccc      720



tggcgggagc cgagaagaat ggtctggtga agatcaaggt ggcggaagac gaggcggagg      780



cggcagccgc ggctaagttc acgggcctgt ccaaggagga gctgctgaag gtggcaggca      840



gccccggctg ggtacgcacc cgctgggcac tgctgctgct cttctggctc ggctggctcg      900



gcatgcttgc tggtgccgtg gtcataatcg tgcgagcgcc gcgttgtcgc gagctaccgg      960



cgcagaagtg gtggcacacg ggcgccctct accgcatcgg cgaccttcag gccttccagg     1020



gccacggcgc gggcaacctg gcgggtctga aggggcgtct cgattacctg agctctctga     1080



aggtgaaggg ccttgtgctg ggtccaattc acaagaacca gaaggatgat gtcgctcaga     1140



ctgacttgct gcagatcgac cccaattttg gctccaagga agattttgac agtctcttgc     1200



aatcggctaa aaaaaagagc atccgtgtca ttctggacct tactcccaac taccggggtg     1260



agaactcgtg gttctccact caggttgaca ctgtggccac caaggtgaag gatgctctgg     1320



agttttggct gcaagctggc gtggatgggt tccaggttcg ggacatagag aatctgaagg     1380



atgcatcctc attcttggct gagtggcaaa atatcaccaa gggcttcagt gaagacaggc     1440



tcttgattgc ggggactaac tcctccgacc ttcagcagat cctgagccta ctcgaatcca     1500



acaaagactt gctgttgact agctcatacc tgtctgattc tggttctact ggggagcata     1560



caaaatccct agtcacacag tatttgaatg ccactggcaa tcgctggtgc agctggagtt     1620



tgtctcaggc aaggctcctg acttccttct tgccggctca acttctccga ctctaccagc     1680



tgatgctctt caccctgcca gggacccctg ttttcagcta cggggatgag attggcctgg     1740



atgcagctgc ccttcctgga cagcctatgg aggctccagt catgctgtgg gatgagtcca     1800



gcttccctga catcccaggg gctgtaagtg ccaacatgac tgtgaagggc cagagtgaag     1860



accctggctc cctcctttcc ttgttccggc ggctgagtga ccagcggagt aaggagcgct     1920



ccctactgca tggggacttc cacgcgttct ccgctgggcc tggactcttc tcctatatcc     1980



gccactggga ccagaatgag cgttttctgg tagtgcttaa ctttggggat gtgggcctct     2040



cggctggact gcaggcctcc gacctgcctg ccagcgccag cctgccagcc aaggctgacc     2100



tcctgctcag cacccagcca ggccgtgagg agggctcccc tcttgagctg gaacgcctga     2160



aactggagcc tcacgaaggg ctgctgctcc gcttccccta cgcggcctga cttcagcctg     2220



acatggaccc actacccttc tcctttcctt cccaggccct ttggcttctg atttttctct     2280



tttttaaaaa caaacaaaca aactgttgca gattatgagt gaacccccaa atagggtgtt     2340



ttctgccttc aaataaaagt cacccctgca tggtgaagtc ttccctctgc ttctctcaaa     2400



aaaaaaaa                                                              2408





<210>  238

<211>  661

<212>  PRT

<213>  Homo sapiens



<400>  238



Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 

1               5                   10                  15      





Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 

            20                  25                  30          





Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 

        35                  40                  45              





Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 

    50                  55                  60                  





Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 

65                  70                  75                  80  





Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 

                85                  90                  95      





Glu Val Thr Glu Thr Gly Phe His His Val Ser Gln Ala Asp Ile Glu 

            100                 105                 110         





Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser Ala Gly 

        115                 120                 125             





Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val 

    130                 135                 140                 





Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser 

145                 150                 155                 160 





Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys 

                165                 170                 175     





Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe 

            180                 185                 190         





Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly 

        195                 200                 205             





Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp 

    210                 215                 220                 





Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg 

225                 230                 235                 240 





Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr 

                245                 250                 255     





Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu 

            260                 265                 270         





Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys 

        275                 280                 285             





Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala 

    290                 295                 300                 





Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp 

305                 310                 315                 320 





Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile 

                325                 330                 335     





Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr 

            340                 345                 350         





Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp 

        355                 360                 365             





Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu 

    370                 375                 380                 





Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly 

385                 390                 395                 400 





Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu 

                405                 410                 415     





Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr 

            420                 425                 430         





Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser 

        435                 440                 445             





Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp 

    450                 455                 460                 





Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu 

465                 470                 475                 480 





Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val 

                485                 490                 495     





Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly 

            500                 505                 510         





Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro 

        515                 520                 525             





Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser 

    530                 535                 540                 





Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln 

545                 550                 555                 560 





Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser 

                565                 570                 575     





Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu 

            580                 585                 590         





Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly 

        595                 600                 605             





Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala 

    610                 615                 620                 





Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu 

625                 630                 635                 640 





Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg 

                645                 650                 655     





Phe Pro Tyr Ala Ala 

            660     





<210>  239

<211>  2318

<212>  DNA

<213>  Homo sapiens



<400>  239

cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg       60



accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc      120



ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg      180



ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc      240



ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg      300



ctggtgtcca gggtctcagc gcgggggacg actcagagac ggggtctgac tgtgttaccc      360



aggctggtct tcaactcttg gcctcaagtg atcctcctgc cttagcttcc aagaatgctg      420



aggttacagt agaaacgggg tttcaccatg ttagccaggc tgatattgaa ttcctgacct      480



caattgatcc gactgcctcg gcctccggaa gtgctgggat tacaggcacc atgagccagg      540



acaccgaggt ggatatgaag gaggtggagc tgaatgagtt agagcccgag aagcagccga      600



tgaacgcggc gtctggggcg gccatgtccc tggcgggagc cgagaagaat ggtctggtga      660



agatcaaggt ggcggaagac gaggcggagg cggcagccgc ggctaagttc acgggcctgt      720



ccaaggagga gctgctgaag gtggcaggca gccccggctg ggtacgcacc cgctgggcac      780



tgctgctgct cttctggctc ggctggctcg gcatgcttgc tggtgccgtg gtcataatcg      840



tgcgagcgcc gcgttgtcgc gagctaccgg cgcagaagtg gtggcacacg ggcgccctct      900



accgcatcgg cgaccttcag gccttccagg gccacggcgc gggcaacctg gcgggtctga      960



aggggcgtct cgattacctg agctctctga aggtgaaggg ccttgtgctg ggtccaattc     1020



acaagaacca gaaggatgat gtcgctcaga ctgacttgct gcagatcgac cccaattttg     1080



gctccaagga agattttgac agtctcttgc aatcggctaa aaaaaagagc atccgtgtca     1140



ttctggacct tactcccaac taccggggtg agaactcgtg gttctccact caggttgaca     1200



ctgtggccac caaggtgaag gatgctctgg agttttggct gcaagctggc gtggatgggt     1260



tccaggttcg ggacatagag aatctgaagg atgcatcctc attcttggct gagtggcaaa     1320



atatcaccaa gggcttcagt gaagacaggc tcttgattgc ggggactaac tcctccgacc     1380



ttcagcagat cctgagccta ctcgaatcca acaaagactt gctgttgact agctcatacc     1440



tgtctgattc tggttctact ggggagcata caaaatccct agtcacacag tatttgaatg     1500



ccactggcaa tcgctggtgc agctggagtt tgtctcaggc aaggctcctg acttccttct     1560



tgccggctca acttctccga ctctaccagc tgatgctctt caccctgcca gggacccctg     1620



ttttcagcta cggggatgag attggcctgg atgcagctgc ccttcctgga cagcctatgg     1680



aggctccagt catgctgtgg gatgagtcca gcttccctga catcccaggg gctgtaagtg     1740



ccaacatgac tgtgaagggc cagagtgaag accctggctc cctcctttcc ttgttccggc     1800



ggctgagtga ccagcggagt aaggagcgct ccctactgca tggggacttc cacgcgttct     1860



ccgctgggcc tggactcttc tcctatatcc gccactggga ccagaatgag cgttttctgg     1920



tagtgcttaa ctttggggat gtgggcctct cggctggact gcaggcctcc gacctgcctg     1980



ccagcgccag cctgccagcc aaggctgacc tcctgctcag cacccagcca ggccgtgagg     2040



agggctcccc tcttgagctg gaacgcctga aactggagcc tcacgaaggg ctgctgctcc     2100



gcttccccta cgcggcctga cttcagcctg acatggaccc actacccttc tcctttcctt     2160



cccaggccct ttggcttctg atttttctct tttttaaaaa caaacaaaca aactgttgca     2220



gattatgagt gaacccccaa atagggtgtt ttctgccttc aaataaaagt cacccctgca     2280



tggtgaagtc ttccctctgc ttctctcaaa aaaaaaaa                             2318





<210>  240

<211>  631

<212>  PRT

<213>  Homo sapiens



<400>  240



Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 

1               5                   10                  15      





Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 

            20                  25                  30          





Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 

        35                  40                  45              





Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 

    50                  55                  60                  





Ala Glu Val Thr Val Glu Thr Gly Phe His His Val Ser Gln Ala Asp 

65                  70                  75                  80  





Ile Glu Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser 

                85                  90                  95      





Ala Gly Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 

            100                 105                 110         





Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 

        115                 120                 125             





Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 

    130                 135                 140                 





Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 

145                 150                 155                 160 





Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 

                165                 170                 175     





Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 

            180                 185                 190         





Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 

        195                 200                 205             





Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 

    210                 215                 220                 





Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 

225                 230                 235                 240 





Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 

                245                 250                 255     





Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 

            260                 265                 270         





Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 

        275                 280                 285             





Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 

    290                 295                 300                 





Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 

305                 310                 315                 320 





Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 

                325                 330                 335     





Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 

            340                 345                 350         





Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 

        355                 360                 365             





Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 

    370                 375                 380                 





Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 

385                 390                 395                 400 





Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 

                405                 410                 415     





Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 

            420                 425                 430         





Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 

        435                 440                 445             





Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 

    450                 455                 460                 





Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 

465                 470                 475                 480 





Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 

                485                 490                 495     





Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 

            500                 505                 510         





Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 

        515                 520                 525             





Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 

    530                 535                 540                 





Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 

545                 550                 555                 560 





Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 

                565                 570                 575     





Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 

            580                 585                 590         





Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 

        595                 600                 605             





Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 

    610                 615                 620                 





Leu Arg Phe Pro Tyr Ala Ala 

625                 630     





<210>  241

<211>  2222

<212>  DNA

<213>  Homo sapiens



<400>  241

cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg       60



accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc      120



ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg      180



ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc      240



ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg      300



ctggtgtcca gggtctcagc gcgggggacg actcagagac ggggtctgac tgtgttaccc      360



aggctggtct tcaactcttg gcctcaagtg atcctcctgc cttagcttcc aagaatgctg      420



aggttacagg caccatgagc caggacaccg aggtggatat gaaggaggtg gagctgaatg      480



agttagagcc cgagaagcag ccgatgaacg cggcgtctgg ggcggccatg tccctggcgg      540



gagccgagaa gaatggtctg gtgaagatca aggtggcgga agacgaggcg gaggcggcag      600



ccgcggctaa gttcacgggc ctgtccaagg aggagctgct gaaggtggca ggcagccccg      660



gctgggtacg cacccgctgg gcactgctgc tgctcttctg gctcggctgg ctcggcatgc      720



ttgctggtgc cgtggtcata atcgtgcgag cgccgcgttg tcgcgagcta ccggcgcaga      780



agtggtggca cacgggcgcc ctctaccgca tcggcgacct tcaggccttc cagggccacg      840



gcgcgggcaa cctggcgggt ctgaaggggc gtctcgatta cctgagctct ctgaaggtga      900



agggccttgt gctgggtcca attcacaaga accagaagga tgatgtcgct cagactgact      960



tgctgcagat cgaccccaat tttggctcca aggaagattt tgacagtctc ttgcaatcgg     1020



ctaaaaaaaa gagcatccgt gtcattctgg accttactcc caactaccgg ggtgagaact     1080



cgtggttctc cactcaggtt gacactgtgg ccaccaaggt gaaggatgct ctggagtttt     1140



ggctgcaagc tggcgtggat gggttccagg ttcgggacat agagaatctg aaggatgcat     1200



cctcattctt ggctgagtgg caaaatatca ccaagggctt cagtgaagac aggctcttga     1260



ttgcggggac taactcctcc gaccttcagc agatcctgag cctactcgaa tccaacaaag     1320



acttgctgtt gactagctca tacctgtctg attctggttc tactggggag catacaaaat     1380



ccctagtcac acagtatttg aatgccactg gcaatcgctg gtgcagctgg agtttgtctc     1440



aggcaaggct cctgacttcc ttcttgccgg ctcaacttct ccgactctac cagctgatgc     1500



tcttcaccct gccagggacc cctgttttca gctacgggga tgagattggc ctggatgcag     1560



ctgcccttcc tggacagcct atggaggctc cagtcatgct gtgggatgag tccagcttcc     1620



ctgacatccc aggggctgta agtgccaaca tgactgtgaa gggccagagt gaagaccctg     1680



gctccctcct ttccttgttc cggcggctga gtgaccagcg gagtaaggag cgctccctac     1740



tgcatgggga cttccacgcg ttctccgctg ggcctggact cttctcctat atccgccact     1800



gggaccagaa tgagcgtttt ctggtagtgc ttaactttgg ggatgtgggc ctctcggctg     1860



gactgcaggc ctccgacctg cctgccagcg ccagcctgcc agccaaggct gacctcctgc     1920



tcagcaccca gccaggccgt gaggagggct cccctcttga gctggaacgc ctgaaactgg     1980



agcctcacga agggctgctg ctccgcttcc cctacgcggc ctgacttcag cctgacatgg     2040



acccactacc cttctccttt ccttcccagg ccctttggct tctgattttt ctctttttta     2100



aaaacaaaca aacaaactgt tgcagattat gagtgaaccc ccaaataggg tgttttctgc     2160



cttcaaataa aagtcacccc tgcatggtga agtcttccct ctgcttctct caaaaaaaaa     2220



aa                                                                    2222





<210>  242

<211>  599

<212>  PRT

<213>  Homo sapiens



<400>  242



Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 

1               5                   10                  15      





Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 

            20                  25                  30          





Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 

        35                  40                  45              





Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 

    50                  55                  60                  





Ala Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 

65                  70                  75                  80  





Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 

                85                  90                  95      





Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 

            100                 105                 110         





Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 

        115                 120                 125             





Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 

    130                 135                 140                 





Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 

145                 150                 155                 160 





Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 

                165                 170                 175     





Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 

            180                 185                 190         





Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 

        195                 200                 205             





Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 

    210                 215                 220                 





Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 

225                 230                 235                 240 





Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 

                245                 250                 255     





Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 

            260                 265                 270         





Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 

        275                 280                 285             





Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 

    290                 295                 300                 





Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 

305                 310                 315                 320 





Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 

                325                 330                 335     





Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 

            340                 345                 350         





Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 

        355                 360                 365             





Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 

    370                 375                 380                 





Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 

385                 390                 395                 400 





Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 

                405                 410                 415     





Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 

            420                 425                 430         





Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 

        435                 440                 445             





Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 

    450                 455                 460                 





Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 

465                 470                 475                 480 





Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 

                485                 490                 495     





Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 

            500                 505                 510         





Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 

        515                 520                 525             





Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 

    530                 535                 540                 





Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 

545                 550                 555                 560 





Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 

                565                 570                 575     





Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 

            580                 585                 590         





Leu Arg Phe Pro Tyr Ala Ala 

        595                 





<210>  243

<211>  2129

<212>  DNA

<213>  Homo sapiens



<400>  243

cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg       60



accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc      120



ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg      180



ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc      240



ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg      300



ctggtgtcca gggtctcagc gcgggggacg actcaggcac catgagccag gacaccgagg      360



tggatatgaa ggaggtggag ctgaatgagt tagagcccga gaagcagccg atgaacgcgg      420



cgtctggggc ggccatgtcc ctggcgggag ccgagaagaa tggtctggtg aagatcaagg      480



tggcggaaga cgaggcggag gcggcagccg cggctaagtt cacgggcctg tccaaggagg      540



agctgctgaa ggtggcaggc agccccggct gggtacgcac ccgctgggca ctgctgctgc      600



tcttctggct cggctggctc ggcatgcttg ctggtgccgt ggtcataatc gtgcgagcgc      660



cgcgttgtcg cgagctaccg gcgcagaagt ggtggcacac gggcgccctc taccgcatcg      720



gcgaccttca ggccttccag ggccacggcg cgggcaacct ggcgggtctg aaggggcgtc      780



tcgattacct gagctctctg aaggtgaagg gccttgtgct gggtccaatt cacaagaacc      840



agaaggatga tgtcgctcag actgacttgc tgcagatcga ccccaatttt ggctccaagg      900



aagattttga cagtctcttg caatcggcta aaaaaaagag catccgtgtc attctggacc      960



ttactcccaa ctaccggggt gagaactcgt ggttctccac tcaggttgac actgtggcca     1020



ccaaggtgaa ggatgctctg gagttttggc tgcaagctgg cgtggatggg ttccaggttc     1080



gggacataga gaatctgaag gatgcatcct cattcttggc tgagtggcaa aatatcacca     1140



agggcttcag tgaagacagg ctcttgattg cggggactaa ctcctccgac cttcagcaga     1200



tcctgagcct actcgaatcc aacaaagact tgctgttgac tagctcatac ctgtctgatt     1260



ctggttctac tggggagcat acaaaatccc tagtcacaca gtatttgaat gccactggca     1320



atcgctggtg cagctggagt ttgtctcagg caaggctcct gacttccttc ttgccggctc     1380



aacttctccg actctaccag ctgatgctct tcaccctgcc agggacccct gttttcagct     1440



acggggatga gattggcctg gatgcagctg cccttcctgg acagcctatg gaggctccag     1500



tcatgctgtg ggatgagtcc agcttccctg acatcccagg ggctgtaagt gccaacatga     1560



ctgtgaaggg ccagagtgaa gaccctggct ccctcctttc cttgttccgg cggctgagtg     1620



accagcggag taaggagcgc tccctactgc atggggactt ccacgcgttc tccgctgggc     1680



ctggactctt ctcctatatc cgccactggg accagaatga gcgttttctg gtagtgctta     1740



actttgggga tgtgggcctc tcggctggac tgcaggcctc cgacctgcct gccagcgcca     1800



gcctgccagc caaggctgac ctcctgctca gcacccagcc aggccgtgag gagggctccc     1860



ctcttgagct ggaacgcctg aaactggagc ctcacgaagg gctgctgctc cgcttcccct     1920



acgcggcctg acttcagcct gacatggacc cactaccctt ctcctttcct tcccaggccc     1980



tttggcttct gatttttctc ttttttaaaa acaaacaaac aaactgttgc agattatgag     2040



tgaaccccca aatagggtgt tttctgcctt caaataaaag tcacccctgc atggtgaagt     2100



cttccctctg cttctctcaa aaaaaaaaa                                       2129





<210>  244

<211>  568

<212>  PRT

<213>  Homo sapiens



<400>  244



Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 

1               5                   10                  15      





Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 

            20                  25                  30          





Ala Gly Asp Asp Ser Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met 

        35                  40                  45              





Lys Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn 

    50                  55                  60                  





Ala Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly 

65                  70                  75                  80  





Leu Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala 

                85                  90                  95      





Ala Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly 

            100                 105                 110         





Ser Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp 

        115                 120                 125             





Leu Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg 

    130                 135                 140                 





Ala Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly 

145                 150                 155                 160 





Ala Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala 

                165                 170                 175     





Gly Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu 

            180                 185                 190         





Lys Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp 

        195                 200                 205             





Asp Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser 

    210                 215                 220                 





Lys Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile 

225                 230                 235                 240 





Arg Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp 

                245                 250                 255     





Phe Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu 

            260                 265                 270         





Glu Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile 

        275                 280                 285             





Glu Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile 

    290                 295                 300                 





Thr Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser 

305                 310                 315                 320 





Ser Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu 

                325                 330                 335     





Leu Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His 

            340                 345                 350         





Thr Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp 

        355                 360                 365             





Cys Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro 

    370                 375                 380                 





Ala Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly 

385                 390                 395                 400 





Thr Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala 

                405                 410                 415     





Leu Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser 

            420                 425                 430         





Ser Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys 

        435                 440                 445             





Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu 

    450                 455                 460                 





Ser Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His 

465                 470                 475                 480 





Ala Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp 

                485                 490                 495     





Gln Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu 

            500                 505                 510         





Ser Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro 

        515                 520                 525             





Ala Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly 

    530                 535                 540                 





Ser Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu 

545                 550                 555                 560 





Leu Leu Arg Phe Pro Tyr Ala Ala 

                565             





<210>  245

<211>  1997

<212>  DNA

<213>  Homo sapiens



<400>  245

agtccccgag gttccacctt aaggggcggg ccggggcggg gctccgctgc cccttcccag       60



aggccgcgcc tgctgctgag cagatgcagt agccgaaact gcgcggaggc acagaggccg      120



gggagagcgt tctgggtccg agggtccagg taggggttga gccaccatct gaccgcaagc      180



tgcgtcgtgt cgccggttct gcaggcacca tgagccagga caccgaggtg gatatgaagg      240



aggtggagct gaatgagtta gagcccgaga agcagccgat gaacgcggcg tctggggcgg      300



ccatgtccct ggcgggagcc gagaagaatg gtctggtgaa gatcaaggtg gcggaagacg      360



aggcggaggc ggcagccgcg gctaagttca cgggcctgtc caaggaggag ctgctgaagg      420



tggcaggcag ccccggctgg gtacgcaccc gctgggcact gctgctgctc ttctggctcg      480



gctggctcgg catgcttgct ggtgccgtgg tcataatcgt gcgagcgccg cgttgtcgcg      540



agctaccggc gcagaagtgg tggcacacgg gcgccctcta ccgcatcggc gaccttcagg      600



ccttccaggg ccacggcgcg ggcaacctgg cgggtctgaa ggggcgtctc gattacctga      660



gctctctgaa ggtgaagggc cttgtgctgg gtccaattca caagaaccag aaggatgatg      720



tcgctcagac tgacttgctg cagatcgacc ccaattttgg ctccaaggaa gattttgaca      780



gtctcttgca atcggctaaa aaaaagagca tccgtgtcat tctggacctt actcccaact      840



accggggtga gaactcgtgg ttctccactc aggttgacac tgtggccacc aaggtgaagg      900



atgctctgga gttttggctg caagctggcg tggatgggtt ccaggttcgg gacatagaga      960



atctgaagga tgcatcctca ttcttggctg agtggcaaaa tatcaccaag ggcttcagtg     1020



aagacaggct cttgattgcg gggactaact cctccgacct tcagcagatc ctgagcctac     1080



tcgaatccaa caaagacttg ctgttgacta gctcatacct gtctgattct ggttctactg     1140



gggagcatac aaaatcccta gtcacacagt atttgaatgc cactggcaat cgctggtgca     1200



gctggagttt gtctcaggca aggctcctga cttccttctt gccggctcaa cttctccgac     1260



tctaccagct gatgctcttc accctgccag ggacccctgt tttcagctac ggggatgaga     1320



ttggcctgga tgcagctgcc cttcctggac agcctatgga ggctccagtc atgctgtggg     1380



atgagtccag cttccctgac atcccagggg ctgtaagtgc caacatgact gtgaagggcc     1440



agagtgaaga ccctggctcc ctcctttcct tgttccggcg gctgagtgac cagcggagta     1500



aggagcgctc cctactgcat ggggacttcc acgcgttctc cgctgggcct ggactcttct     1560



cctatatccg ccactgggac cagaatgagc gttttctggt agtgcttaac tttggggatg     1620



tgggcctctc ggctggactg caggcctccg acctgcctgc cagcgccagc ctgccagcca     1680



aggctgacct cctgctcagc acccagccag gccgtgagga gggctcccct cttgagctgg     1740



aacgcctgaa actggagcct cacgaagggc tgctgctccg cttcccctac gcggcctgac     1800



ttcagcctga catggaccca ctacccttct cctttccttc ccaggccctt tggcttctga     1860



tttttctctt ttttaaaaac aaacaaacaa actgttgcag attatgagtg aacccccaaa     1920



tagggtgttt tctgccttca aataaaagtc acccctgcat ggtgaagtct tccctctgct     1980



tctctcaaaa aaaaaaa                                                    1997





<210>  246

<211>  529

<212>  PRT

<213>  Homo sapiens



<400>  246



Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 

1               5                   10                  15      





Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 

            20                  25                  30          





Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 

        35                  40                  45              





Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 

    50                  55                  60                  





Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 

65                  70                  75                  80  





Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 

                85                  90                  95      





Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 

            100                 105                 110         





Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 

        115                 120                 125             





Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys 

    130                 135                 140                 





Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu 

145                 150                 155                 160 





Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu 

                165                 170                 175     





Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu 

            180                 185                 190         





Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr 

        195                 200                 205             





Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr 

    210                 215                 220                 





Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly 

225                 230                 235                 240 





Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser 

                245                 250                 255     





Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp 

            260                 265                 270         





Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu 

        275                 280                 285             





Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu 

    290                 295                 300                 





Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln 

305                 310                 315                 320 





Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln 

                325                 330                 335     





Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr 

            340                 345                 350         





Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly 

        355                 360                 365             





Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu 

    370                 375                 380                 





Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly 

385                 390                 395                 400 





Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly 

                405                 410                 415     





Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu 

            420                 425                 430         





Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly 

        435                 440                 445             





Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val 

    450                 455                 460                 





Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser 

465                 470                 475                 480 





Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu 

                485                 490                 495     





Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg 

            500                 505                 510         





Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala 

        515                 520                 525             





Ala 

    





<210>  247

<211>  2315

<212>  DNA

<213>  Homo sapiens



<400>  247

cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg       60



accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc      120



ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg      180



ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc      240



ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg      300



ctggtgtcca gggtctcagc gcgggggacg actcagagtt ggggtctcac tgtgttgccc      360



agactggtct cgaactcttg gcctcaggtg atcctcttcc ctcagcttcc cagaatgccg      420



agatgataga gacggggtct gactgtgtta cccaggctgg tcttcaactc ttggcctcaa      480



gtgatcctcc tgccttagct tccaagaatg ctgaggttac aggcaccatg agccaggaca      540



ccgaggtgga tatgaaggag gtggagctga atgagttaga gcccgagaag cagccgatga      600



acgcggcgtc tggggcggcc atgtccctgg cgggagccga gaagaatggt ctggtgaaga      660



tcaaggtggc ggaagacgag gcggaggcgg cagccgcggc taagttcacg ggcctgtcca      720



aggaggagct gctgaaggtg gcaggcagcc ccggctgggt acgcacccgc tgggcactgc      780



tgctgctctt ctggctcggc tggctcggca tgcttgctgg tgccgtggtc ataatcgtgc      840



gagcgccgcg ttgtcgcgag ctaccggcgc agaagtggtg gcacacgggc gccctctacc      900



gcatcggcga ccttcaggcc ttccagggcc acggcgcggg caacctggcg ggtctgaagg      960



ggcgtctcga ttacctgagc tctctgaagg tgaagggcct tgtgctgggt ccaattcaca     1020



agaaccagaa ggatgatgtc gctcagactg acttgctgca gatcgacccc aattttggct     1080



ccaaggaaga ttttgacagt ctcttgcaat cggctaaaaa aaagagcatc cgtgtcattc     1140



tggaccttac tcccaactac cggggtgaga actcgtggtt ctccactcag gttgacactg     1200



tggccaccaa ggtgaaggat gctctggagt tttggctgca agctggcgtg gatgggttcc     1260



aggttcggga catagagaat ctgaaggatg catcctcatt cttggctgag tggcaaaata     1320



tcaccaaggg cttcagtgaa gacaggctct tgattgcggg gactaactcc tccgaccttc     1380



agcagatcct gagcctactc gaatccaaca aagacttgct gttgactagc tcatacctgt     1440



ctgattctgg ttctactggg gagcatacaa aatccctagt cacacagtat ttgaatgcca     1500



ctggcaatcg ctggtgcagc tggagtttgt ctcaggcaag gctcctgact tccttcttgc     1560



cggctcaact tctccgactc taccagctga tgctcttcac cctgccaggg acccctgttt     1620



tcagctacgg ggatgagatt ggcctggatg cagctgccct tcctggacag cctatggagg     1680



ctccagtcat gctgtgggat gagtccagct tccctgacat cccaggggct gtaagtgcca     1740



acatgactgt gaagggccag agtgaagacc ctggctccct cctttccttg ttccggcggc     1800



tgagtgacca gcggagtaag gagcgctccc tactgcatgg ggacttccac gcgttctccg     1860



ctgggcctgg actcttctcc tatatccgcc actgggacca gaatgagcgt tttctggtag     1920



tgcttaactt tggggatgtg ggcctctcgg ctggactgca ggcctccgac ctgcctgcca     1980



gcgccagcct gccagccaag gctgacctcc tgctcagcac ccagccaggc cgtgaggagg     2040



gctcccctct tgagctggaa cgcctgaaac tggagcctca cgaagggctg ctgctccgct     2100



tcccctacgc ggcctgactt cagcctgaca tggacccact acccttctcc tttccttccc     2160



aggccctttg gcttctgatt tttctctttt ttaaaaacaa acaaacaaac tgttgcagat     2220



tatgagtgaa cccccaaata gggtgttttc tgccttcaaa taaaagtcac ccctgcatgg     2280



tgaagtcttc cctctgcttc tctcaaaaaa aaaaa                                2315





<210>  248

<211>  630

<212>  PRT

<213>  Homo sapiens



<400>  248



Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 

1               5                   10                  15      





Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 

            20                  25                  30          





Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 

        35                  40                  45              





Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 

    50                  55                  60                  





Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 

65                  70                  75                  80  





Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 

                85                  90                  95      





Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 

            100                 105                 110         





Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 

        115                 120                 125             





Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 

    130                 135                 140                 





Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 

145                 150                 155                 160 





Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 

                165                 170                 175     





Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 

            180                 185                 190         





Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 

        195                 200                 205             





Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 

    210                 215                 220                 





Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 

225                 230                 235                 240 





Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 

                245                 250                 255     





Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 

            260                 265                 270         





Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 

        275                 280                 285             





Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 

    290                 295                 300                 





Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 

305                 310                 315                 320 





Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 

                325                 330                 335     





Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 

            340                 345                 350         





Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 

        355                 360                 365             





Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 

    370                 375                 380                 





Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 

385                 390                 395                 400 





Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 

                405                 410                 415     





Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 

            420                 425                 430         





Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 

        435                 440                 445             





Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 

    450                 455                 460                 





Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 

465                 470                 475                 480 





Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 

                485                 490                 495     





Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 

            500                 505                 510         





Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 

        515                 520                 525             





Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 

    530                 535                 540                 





Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 

545                 550                 555                 560 





Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 

                565                 570                 575     





Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 

            580                 585                 590         





Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 

        595                 600                 605             





Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 

    610                 615                 620                 





Arg Phe Pro Tyr Ala Ala 

625                 630 





<210>  249

<211>  1134

<212>  DNA

<213>  Homo sapiens



<400>  249

gttctcattt ttctactgct cgtggattta cgcgcacgtt ggaaccgaag agagctctgt       60



tgttgcaatg ttcagcccac aagagcttac tggtgaagga atgggacaag acccatcttt      120



atgcaaagcc agcgttacag taatgttcca gcatctcata atctatcctg gggaattcag      180



ctgcctccca gggtgaatac aggtattcct gatgacagtc tgcctctatc ttacagagca      240



gcttgttgct atataccatt gaaaagcctt cagagctgag aggtactact aaccaataac      300



ctgcttggct caaagggcca gcaccttctc tctaaagccc aagaggagtt tgaggaaaac      360



taggtgtctg tgttcactcc aggctgaagt tacaggtctg agcaaataag gtgtataaaa      420



aatggaatct gtcttggagg acatcagaag gtgaattttc caagttcttg gacaacctag      480



ctgttgaaaa gctttctggg tttggggggt atttcagatg taccttaaag tgttagcaga      540



cacagattaa gacactggga gccaatgaaa cagcagttga gggtttgctg tgtatcacat      600



ttctgtattt tatcaccccc ttcctgcaac attatttatc tggaatctac ctgccctttt      660



gttttttaga tacaagggct tggttttgtt acccaggctg gtttcaaggc catagcttta      720



agagatcctc tcaccacaga tttccaaagt gctgggattg caggtgtgat tcatggcacc      780



cagactttgc tgcctttctt acatgatcca ggcccagaac ccaaactcag gcactgtata      840



gatgaccact ttcgtaaact actgacctag cttgttgcca attgttgatt gaacttccca      900



taactccact tcgtgtctgt tcctctgtat acagccacct tctgttcccg tcatgagcct      960



ttaggtctcc atttgcatat tgcaaatact atgttccatg taggtagctc attcagggcc     1020



ttgctcttca cttcaaaaaa ggttcccttg aggactggct gtcaatttgt gttgctgtgt     1080



tggttgttga tgaaaataat aaaatgattg attacataaa aaaaaaaaaa aaaa           1134





<210>  250

<211>  2716

<212>  DNA

<213>  Homo sapiens



<400>  250

attccaggac ttccgggcac ttcgtaaggt ttaaaaagga tgcttcgcgt tttctctctc       60



ctttttggag acagattcgc agtggtcgct tcttctcctt ggatttgtta aggattccaa      120



gtaactctta tttggagaga agacgatctg cacttcgcat tttggcattg acatttaatt      180



ttagggtcct ttatatagaa gggagagtag ctacatgaat gtgtaagatc ttggaggaag      240



acagcagaga gagagagaga gatcagagat cccagggtta aaagttggag aaatttcaca      300



gtacatcatc caaaagagga gtccatgatg gaggcagagg taaacttgga gaggacagga      360



agatgtcacc caagcgcata gctaaaagaa ggtccccccc agcagatgcc atccccaaaa      420



gcaagaaggt gaaggtctca cacaggtccc acagcacaga acccggcttg gtgctgacac      480



taggccaggg cgacgtgggc cagctggggc tgggtgagaa tgtgatggag aggaagaagc      540



cggccctggt atccattccg gaggatgttg tgcaggctga ggctgggggc atgcacaccg      600



tgtgtctaag caaaagtggc caggtctatt ccttcggctg caatgatgag ggtgccctgg      660



gaagggacac atcagtggag ggctcggaga tggtccctgg gaaagtggag ctgcaagaga      720



aggtggtaca ggtgtcagca ggagacagtc acacagcagc cctcaccgat gatggccgtg      780



tcttcctctg gggctccttc cgggacaata acggtgtgat tggactgttg gagcccatga      840



agaagagcat ggtgcctgtg caggtgcagc tggatgtgcc tgtggtaaag gtggcctcag      900



gaaacgacca cttggtgatg ctgacagctg atggtgacct ctacaccttg ggctgcgggg      960



aacagggcca gctaggccgt gtgcctgagt tatttgccaa ccgtggtggc cggcaaggcc     1020



tcgaacgact cctggtcccc aagtgtgtga tgctgaaatc caggggaagc cggggccacg     1080



tgagattcca ggatgccttt tgtggtgcct atttcacctt tgccatctcc catgagggcc     1140



acgtgtacgg cttcggcctc tccaactacc atcagcttgg aactccgggc acagaatctt     1200



gcttcatacc ccagaaccta acatccttca agaattccac caagtcctgg gtgggcttct     1260



ctggtggcca gcaccataca gtctgcatgg attcggaagg aaaagcatac agcctgggcc     1320



gggctgagta tgggcggctg ggccttggag agggtgctga ggagaagagc atacccaccc     1380



tcatctccag gctgcctgct gtctcctcgg tggcttgtgg ggcctctgtg gggtatgctg     1440



tgaccaagga tggtcgtgtt ttcgcctggg gcatgggcac caactaccag ctgggcacag     1500



ggcaggatga ggacgcctgg agccctgtgg agatgatggg caaacagctg gagaaccgtg     1560



tggtcttatc tgtgtccagc gggggccagc atacagtctt attagtcaag gacaaagaac     1620



agagctgatg aagcctctga gggcctggct tctgtcctgc acaacctccc tcacagaaca     1680



gggaagcagt gacagctgca gatggcagcg ggcctctccc cagccctgag cactgtgtca     1740



gttcctgcct tttctcatca gcagaacaga atccttttcc tcttttcctt cctcctcttt     1800



ggaattttcc tgggacctac agaataaagg gggggatgga cagggggttt tcaaaaggaa     1860



catggctcac tcagagctat atggttagac gtttctcccc ttttccctac cttccatggt     1920



cctggttggc cctggctttg cctactagaa aaccaaaact tcccccctgg ggttttgtgc     1980



ccactctctg agaagttggg gctccatcaa gccccattct agtcatgtgc ccctttcctg     2040



tccctaacag tccacaggca aacaaatggt acagtcataa gagccatctg tcacggaccc     2100



acgcccagag gaacgtgcag aaaaaagcag agctacatgg ctgtgggcaa ctataagcca     2160



aatatttggc tcagaacagg tgtccatggg acaaaaaaga acgatcctcc acttgaccaa     2220



gaaaaaagtg attctcccag aagcacaaag catactcttg cccctcaggt gttgcttgtg     2280



tacatcgtac ccatccattc ggcttcacct gcagccaacg gcctggaatc gcaaagagac     2340



accactctgg gcagagcaga gcagggtatg gggtggggag agagggtgga gggttttata     2400



aacaaactta acagcaatat tgaaaggagg tgggggattg agggagggac agagtgttgg     2460



agggccagag actagtcctg agatggaaac agcaacttgt acagtggctg agaaaatagg     2520



atatagtttt gattttttta attgtaaaat attttggagg gagaacaaaa tcttttaaca     2580



ttttgaataa atttagagtt ttataaaata ggccacttgt tttctacaca ttccctgctt     2640



tttaagggag cacatattat gtgccaggca ctgctgggaa agacagaata aactataaac     2700



ctggtgttga ggctac                                                     2716





<210>  251

<211>  421

<212>  PRT

<213>  Homo sapiens



<400>  251



Met Ser Pro Lys Arg Ile Ala Lys Arg Arg Ser Pro Pro Ala Asp Ala 

1               5                   10                  15      





Ile Pro Lys Ser Lys Lys Val Lys Val Ser His Arg Ser His Ser Thr 

            20                  25                  30          





Glu Pro Gly Leu Val Leu Thr Leu Gly Gln Gly Asp Val Gly Gln Leu 

        35                  40                  45              





Gly Leu Gly Glu Asn Val Met Glu Arg Lys Lys Pro Ala Leu Val Ser 

    50                  55                  60                  





Ile Pro Glu Asp Val Val Gln Ala Glu Ala Gly Gly Met His Thr Val 

65                  70                  75                  80  





Cys Leu Ser Lys Ser Gly Gln Val Tyr Ser Phe Gly Cys Asn Asp Glu 

                85                  90                  95      





Gly Ala Leu Gly Arg Asp Thr Ser Val Glu Gly Ser Glu Met Val Pro 

            100                 105                 110         





Gly Lys Val Glu Leu Gln Glu Lys Val Val Gln Val Ser Ala Gly Asp 

        115                 120                 125             





Ser His Thr Ala Ala Leu Thr Asp Asp Gly Arg Val Phe Leu Trp Gly 

    130                 135                 140                 





Ser Phe Arg Asp Asn Asn Gly Val Ile Gly Leu Leu Glu Pro Met Lys 

145                 150                 155                 160 





Lys Ser Met Val Pro Val Gln Val Gln Leu Asp Val Pro Val Val Lys 

                165                 170                 175     





Val Ala Ser Gly Asn Asp His Leu Val Met Leu Thr Ala Asp Gly Asp 

            180                 185                 190         





Leu Tyr Thr Leu Gly Cys Gly Glu Gln Gly Gln Leu Gly Arg Val Pro 

        195                 200                 205             





Glu Leu Phe Ala Asn Arg Gly Gly Arg Gln Gly Leu Glu Arg Leu Leu 

    210                 215                 220                 





Val Pro Lys Cys Val Met Leu Lys Ser Arg Gly Ser Arg Gly His Val 

225                 230                 235                 240 





Arg Phe Gln Asp Ala Phe Cys Gly Ala Tyr Phe Thr Phe Ala Ile Ser 

                245                 250                 255     





His Glu Gly His Val Tyr Gly Phe Gly Leu Ser Asn Tyr His Gln Leu 

            260                 265                 270         





Gly Thr Pro Gly Thr Glu Ser Cys Phe Ile Pro Gln Asn Leu Thr Ser 

        275                 280                 285             





Phe Lys Asn Ser Thr Lys Ser Trp Val Gly Phe Ser Gly Gly Gln His 

    290                 295                 300                 





His Thr Val Cys Met Asp Ser Glu Gly Lys Ala Tyr Ser Leu Gly Arg 

305                 310                 315                 320 





Ala Glu Tyr Gly Arg Leu Gly Leu Gly Glu Gly Ala Glu Glu Lys Ser 

                325                 330                 335     





Ile Pro Thr Leu Ile Ser Arg Leu Pro Ala Val Ser Ser Val Ala Cys 

            340                 345                 350         





Gly Ala Ser Val Gly Tyr Ala Val Thr Lys Asp Gly Arg Val Phe Ala 

        355                 360                 365             





Trp Gly Met Gly Thr Asn Tyr Gln Leu Gly Thr Gly Gln Asp Glu Asp 

    370                 375                 380                 





Ala Trp Ser Pro Val Glu Met Met Gly Lys Gln Leu Glu Asn Arg Val 

385                 390                 395                 400 





Val Leu Ser Val Ser Ser Gly Gly Gln His Thr Val Leu Leu Val Lys 

                405                 410                 415     





Asp Lys Glu Gln Ser 

            420     





<210>  252

<211>  2712

<212>  DNA

<213>  Homo sapiens



<400>  252

attccaggac ttccgggcac ttcgtaaggt ttaaaaagga tgcttcgcgt tttctctctc       60



ctttttggag acagattcgc agtggtcgct tcttctcctt ggatttgtta aggattccaa      120



gtaactctta tttggagaga agacgatctg cacttcgcat tttggcattg acatttaatt      180



ttagggtcct ttatatagaa gggagactac atgaatgtgt aagatcttgg aggaagacag      240



cagagagaga gagagagatc agagatccca gggttaaaag ttggagaaat ttcacagtac      300



atcatccaaa agaggagtcc atgatggagg cagaggtaaa cttggagagg acaggaagat      360



gtcacccaag cgcatagcta aaagaaggtc ccccccagca gatgccatcc ccaaaagcaa      420



gaaggtgaag gtctcacaca ggtcccacag cacagaaccc ggcttggtgc tgacactagg      480



ccagggcgac gtgggccagc tggggctggg tgagaatgtg atggagagga agaagccggc      540



cctggtatcc attccggagg atgttgtgca ggctgaggct gggggcatgc acaccgtgtg      600



tctaagcaaa agtggccagg tctattcctt cggctgcaat gatgagggtg ccctgggaag      660



ggacacatca gtggagggct cggagatggt ccctgggaaa gtggagctgc aagagaaggt      720



ggtacaggtg tcagcaggag acagtcacac agcagccctc accgatgatg gccgtgtctt      780



cctctggggc tccttccggg acaataacgg tgtgattgga ctgttggagc ccatgaagaa      840



gagcatggtg cctgtgcagg tgcagctgga tgtgcctgtg gtaaaggtgg cctcaggaaa      900



cgaccacttg gtgatgctga cagctgatgg tgacctctac accttgggct gcggggaaca      960



gggccagcta ggccgtgtgc ctgagttatt tgccaaccgt ggtggccggc aaggcctcga     1020



acgactcctg gtccccaagt gtgtgatgct gaaatccagg ggaagccggg gccacgtgag     1080



attccaggat gccttttgtg gtgcctattt cacctttgcc atctcccatg agggccacgt     1140



gtacggcttc ggcctctcca actaccatca gcttggaact ccgggcacag aatcttgctt     1200



cataccccag aacctaacat ccttcaagaa ttccaccaag tcctgggtgg gcttctctgg     1260



tggccagcac catacagtct gcatggattc ggaaggaaaa gcatacagcc tgggccgggc     1320



tgagtatggg cggctgggcc ttggagaggg tgctgaggag aagagcatac ccaccctcat     1380



ctccaggctg cctgctgtct cctcggtggc ttgtggggcc tctgtggggt atgctgtgac     1440



caaggatggt cgtgttttcg cctggggcat gggcaccaac taccagctgg gcacagggca     1500



ggatgaggac gcctggagcc ctgtggagat gatgggcaaa cagctggaga accgtgtggt     1560



cttatctgtg tccagcgggg gccagcatac agtcttatta gtcaaggaca aagaacagag     1620



ctgatgaagc ctctgagggc ctggcttctg tcctgcacaa cctccctcac agaacaggga     1680



agcagtgaca gctgcagatg gcagcgggcc tctccccagc cctgagcact gtgtcagttc     1740



ctgccttttc tcatcagcag aacagaatcc ttttcctctt ttccttcctc ctctttggaa     1800



ttttcctggg acctacagaa taaagggggg gatggacagg gggttttcaa aaggaacatg     1860



gctcactcag agctatatgg ttagacgttt ctcccctttt ccctaccttc catggtcctg     1920



gttggccctg gctttgccta ctagaaaacc aaaacttccc ccctggggtt ttgtgcccac     1980



tctctgagaa gttggggctc catcaagccc cattctagtc atgtgcccct ttcctgtccc     2040



taacagtcca caggcaaaca aatggtacag tcataagagc catctgtcac ggacccacgc     2100



ccagaggaac gtgcagaaaa aagcagagct acatggctgt gggcaactat aagccaaata     2160



tttggctcag aacaggtgtc catgggacaa aaaagaacga tcctccactt gaccaagaaa     2220



aaagtgattc tcccagaagc acaaagcata ctcttgcccc tcaggtgttg cttgtgtaca     2280



tcgtacccat ccattcggct tcacctgcag ccaacggcct ggaatcgcaa agagacacca     2340



ctctgggcag agcagagcag ggtatggggt ggggagagag ggtggagggt tttataaaca     2400



aacttaacag caatattgaa aggaggtggg ggattgaggg agggacagag tgttggaggg     2460



ccagagacta gtcctgagat ggaaacagca acttgtacag tggctgagaa aataggatat     2520



agttttgatt tttttaattg taaaatattt tggagggaga acaaaatctt ttaacatttt     2580



gaataaattt agagttttat aaaataggcc acttgttttc tacacattcc ctgcttttta     2640



agggagcaca tattatgtgc caggcactgc tgggaaagac agaataaact ataaacctgg     2700



tgttgaggct ac                                                         2712





<210>  253

<211>  421

<212>  PRT

<213>  Homo sapiens



<400>  253



Met Ser Pro Lys Arg Ile Ala Lys Arg Arg Ser Pro Pro Ala Asp Ala 

1               5                   10                  15      





Ile Pro Lys Ser Lys Lys Val Lys Val Ser His Arg Ser His Ser Thr 

            20                  25                  30          





Glu Pro Gly Leu Val Leu Thr Leu Gly Gln Gly Asp Val Gly Gln Leu 

        35                  40                  45              





Gly Leu Gly Glu Asn Val Met Glu Arg Lys Lys Pro Ala Leu Val Ser 

    50                  55                  60                  





Ile Pro Glu Asp Val Val Gln Ala Glu Ala Gly Gly Met His Thr Val 

65                  70                  75                  80  





Cys Leu Ser Lys Ser Gly Gln Val Tyr Ser Phe Gly Cys Asn Asp Glu 

                85                  90                  95      





Gly Ala Leu Gly Arg Asp Thr Ser Val Glu Gly Ser Glu Met Val Pro 

            100                 105                 110         





Gly Lys Val Glu Leu Gln Glu Lys Val Val Gln Val Ser Ala Gly Asp 

        115                 120                 125             





Ser His Thr Ala Ala Leu Thr Asp Asp Gly Arg Val Phe Leu Trp Gly 

    130                 135                 140                 





Ser Phe Arg Asp Asn Asn Gly Val Ile Gly Leu Leu Glu Pro Met Lys 

145                 150                 155                 160 





Lys Ser Met Val Pro Val Gln Val Gln Leu Asp Val Pro Val Val Lys 

                165                 170                 175     





Val Ala Ser Gly Asn Asp His Leu Val Met Leu Thr Ala Asp Gly Asp 

            180                 185                 190         





Leu Tyr Thr Leu Gly Cys Gly Glu Gln Gly Gln Leu Gly Arg Val Pro 

        195                 200                 205             





Glu Leu Phe Ala Asn Arg Gly Gly Arg Gln Gly Leu Glu Arg Leu Leu 

    210                 215                 220                 





Val Pro Lys Cys Val Met Leu Lys Ser Arg Gly Ser Arg Gly His Val 

225                 230                 235                 240 





Arg Phe Gln Asp Ala Phe Cys Gly Ala Tyr Phe Thr Phe Ala Ile Ser 

                245                 250                 255     





His Glu Gly His Val Tyr Gly Phe Gly Leu Ser Asn Tyr His Gln Leu 

            260                 265                 270         





Gly Thr Pro Gly Thr Glu Ser Cys Phe Ile Pro Gln Asn Leu Thr Ser 

        275                 280                 285             





Phe Lys Asn Ser Thr Lys Ser Trp Val Gly Phe Ser Gly Gly Gln His 

    290                 295                 300                 





His Thr Val Cys Met Asp Ser Glu Gly Lys Ala Tyr Ser Leu Gly Arg 

305                 310                 315                 320 





Ala Glu Tyr Gly Arg Leu Gly Leu Gly Glu Gly Ala Glu Glu Lys Ser 

                325                 330                 335     





Ile Pro Thr Leu Ile Ser Arg Leu Pro Ala Val Ser Ser Val Ala Cys 

            340                 345                 350         





Gly Ala Ser Val Gly Tyr Ala Val Thr Lys Asp Gly Arg Val Phe Ala 

        355                 360                 365             





Trp Gly Met Gly Thr Asn Tyr Gln Leu Gly Thr Gly Gln Asp Glu Asp 

    370                 375                 380                 





Ala Trp Ser Pro Val Glu Met Met Gly Lys Gln Leu Glu Asn Arg Val 

385                 390                 395                 400 





Val Leu Ser Val Ser Ser Gly Gly Gln His Thr Val Leu Leu Val Lys 

                405                 410                 415     





Asp Lys Glu Gln Ser 

            420     





<210>  254

<211>  2573

<212>  DNA

<213>  Homo sapiens



<400>  254

attccaggac ttccgggcac ttcgtaaggt ttaaaaagga tgcttcgcgt tttctctctc       60



ctttttggag acagattcgc agtggtcgct tcttctcctt ggatttgtta aggattccaa      120



gtaactctta tttggagaga agacgatctg cacttcgcat tttggcattg acatttaatt      180



ttagggtcct ttatatagaa gggagagtag gacaggaaga tgtcacccaa gcgcatagct      240



aaaagaaggt cccccccagc agatgccatc cccaaaagca agaaggtgaa ggtctcacac      300



aggtcccaca gcacagaacc cggcttggtg ctgacactag gccagggcga cgtgggccag      360



ctggggctgg gtgagaatgt gatggagagg aagaagccgg ccctggtatc cattccggag      420



gatgttgtgc aggctgaggc tgggggcatg cacaccgtgt gtctaagcaa aagtggccag      480



gtctattcct tcggctgcaa tgatgagggt gccctgggaa gggacacatc agtggagggc      540



tcggagatgg tccctgggaa agtggagctg caagagaagg tggtacaggt gtcagcagga      600



gacagtcaca cagcagccct caccgatgat ggccgtgtct tcctctgggg ctccttccgg      660



gacaataacg gtgtgattgg actgttggag cccatgaaga agagcatggt gcctgtgcag      720



gtgcagctgg atgtgcctgt ggtaaaggtg gcctcaggaa acgaccactt ggtgatgctg      780



acagctgatg gtgacctcta caccttgggc tgcggggaac agggccagct aggccgtgtg      840



cctgagttat ttgccaaccg tggtggccgg caaggcctcg aacgactcct ggtccccaag      900



tgtgtgatgc tgaaatccag gggaagccgg ggccacgtga gattccagga tgccttttgt      960



ggtgcctatt tcacctttgc catctcccat gagggccacg tgtacggctt cggcctctcc     1020



aactaccatc agcttggaac tccgggcaca gaatcttgct tcatacccca gaacctaaca     1080



tccttcaaga attccaccaa gtcctgggtg ggcttctctg gtggccagca ccatacagtc     1140



tgcatggatt cggaaggaaa agcatacagc ctgggccggg ctgagtatgg gcggctgggc     1200



cttggagagg gtgctgagga gaagagcata cccaccctca tctccaggct gcctgctgtc     1260



tcctcggtgg cttgtggggc ctctgtgggg tatgctgtga ccaaggatgg tcgtgttttc     1320



gcctggggca tgggcaccaa ctaccagctg ggcacagggc aggatgagga cgcctggagc     1380



cctgtggaga tgatgggcaa acagctggag aaccgtgtgg tcttatctgt gtccagcggg     1440



ggccagcata cagtcttatt agtcaaggac aaagaacaga gctgatgaag cctctgaggg     1500



cctggcttct gtcctgcaca acctccctca cagaacaggg aagcagtgac agctgcagat     1560



ggcagcgggc ctctccccag ccctgagcac tgtgtcagtt cctgcctttt ctcatcagca     1620



gaacagaatc cttttcctct tttccttcct cctctttgga attttcctgg gacctacaga     1680



ataaaggggg ggatggacag ggggttttca aaaggaacat ggctcactca gagctatatg     1740



gttagacgtt tctccccttt tccctacctt ccatggtcct ggttggccct ggctttgcct     1800



actagaaaac caaaacttcc cccctggggt tttgtgccca ctctctgaga agttggggct     1860



ccatcaagcc ccattctagt catgtgcccc tttcctgtcc ctaacagtcc acaggcaaac     1920



aaatggtaca gtcataagag ccatctgtca cggacccacg cccagaggaa cgtgcagaaa     1980



aaagcagagc tacatggctg tgggcaacta taagccaaat atttggctca gaacaggtgt     2040



ccatgggaca aaaaagaacg atcctccact tgaccaagaa aaaagtgatt ctcccagaag     2100



cacaaagcat actcttgccc ctcaggtgtt gcttgtgtac atcgtaccca tccattcggc     2160



ttcacctgca gccaacggcc tggaatcgca aagagacacc actctgggca gagcagagca     2220



gggtatgggg tggggagaga gggtggaggg ttttataaac aaacttaaca gcaatattga     2280



aaggaggtgg gggattgagg gagggacaga gtgttggagg gccagagact agtcctgaga     2340



tggaaacagc aacttgtaca gtggctgaga aaataggata tagttttgat ttttttaatt     2400



gtaaaatatt ttggagggag aacaaaatct tttaacattt tgaataaatt tagagtttta     2460



taaaataggc cacttgtttt ctacacattc cctgcttttt aagggagcac atattatgtg     2520



ccaggcactg ctgggaaaga cagaataaac tataaacctg gtgttgaggc tac            2573





<210>  255

<211>  421

<212>  PRT

<213>  Homo sapiens



<400>  255



Met Ser Pro Lys Arg Ile Ala Lys Arg Arg Ser Pro Pro Ala Asp Ala 

1               5                   10                  15      





Ile Pro Lys Ser Lys Lys Val Lys Val Ser His Arg Ser His Ser Thr 

            20                  25                  30          





Glu Pro Gly Leu Val Leu Thr Leu Gly Gln Gly Asp Val Gly Gln Leu 

        35                  40                  45              





Gly Leu Gly Glu Asn Val Met Glu Arg Lys Lys Pro Ala Leu Val Ser 

    50                  55                  60                  





Ile Pro Glu Asp Val Val Gln Ala Glu Ala Gly Gly Met His Thr Val 

65                  70                  75                  80  





Cys Leu Ser Lys Ser Gly Gln Val Tyr Ser Phe Gly Cys Asn Asp Glu 

                85                  90                  95      





Gly Ala Leu Gly Arg Asp Thr Ser Val Glu Gly Ser Glu Met Val Pro 

            100                 105                 110         





Gly Lys Val Glu Leu Gln Glu Lys Val Val Gln Val Ser Ala Gly Asp 

        115                 120                 125             





Ser His Thr Ala Ala Leu Thr Asp Asp Gly Arg Val Phe Leu Trp Gly 

    130                 135                 140                 





Ser Phe Arg Asp Asn Asn Gly Val Ile Gly Leu Leu Glu Pro Met Lys 

145                 150                 155                 160 





Lys Ser Met Val Pro Val Gln Val Gln Leu Asp Val Pro Val Val Lys 

                165                 170                 175     





Val Ala Ser Gly Asn Asp His Leu Val Met Leu Thr Ala Asp Gly Asp 

            180                 185                 190         





Leu Tyr Thr Leu Gly Cys Gly Glu Gln Gly Gln Leu Gly Arg Val Pro 

        195                 200                 205             





Glu Leu Phe Ala Asn Arg Gly Gly Arg Gln Gly Leu Glu Arg Leu Leu 

    210                 215                 220                 





Val Pro Lys Cys Val Met Leu Lys Ser Arg Gly Ser Arg Gly His Val 

225                 230                 235                 240 





Arg Phe Gln Asp Ala Phe Cys Gly Ala Tyr Phe Thr Phe Ala Ile Ser 

                245                 250                 255     





His Glu Gly His Val Tyr Gly Phe Gly Leu Ser Asn Tyr His Gln Leu 

            260                 265                 270         





Gly Thr Pro Gly Thr Glu Ser Cys Phe Ile Pro Gln Asn Leu Thr Ser 

        275                 280                 285             





Phe Lys Asn Ser Thr Lys Ser Trp Val Gly Phe Ser Gly Gly Gln His 

    290                 295                 300                 





His Thr Val Cys Met Asp Ser Glu Gly Lys Ala Tyr Ser Leu Gly Arg 

305                 310                 315                 320 





Ala Glu Tyr Gly Arg Leu Gly Leu Gly Glu Gly Ala Glu Glu Lys Ser 

                325                 330                 335     





Ile Pro Thr Leu Ile Ser Arg Leu Pro Ala Val Ser Ser Val Ala Cys 

            340                 345                 350         





Gly Ala Ser Val Gly Tyr Ala Val Thr Lys Asp Gly Arg Val Phe Ala 

        355                 360                 365             





Trp Gly Met Gly Thr Asn Tyr Gln Leu Gly Thr Gly Gln Asp Glu Asp 

    370                 375                 380                 





Ala Trp Ser Pro Val Glu Met Met Gly Lys Gln Leu Glu Asn Arg Val 

385                 390                 395                 400 





Val Leu Ser Val Ser Ser Gly Gly Gln His Thr Val Leu Leu Val Lys 

                405                 410                 415     





Asp Lys Glu Gln Ser 

            420     





<210>  256

<211>  207

<212>  DNA

<213>  Homo sapiens



<400>  256

tccaacgtgg atacacccgg gaggtcactc tccccgggct ctgtccaagt ggcgtagggg       60



agcatagggc tctgccccat gatgtacaag tccctttcca caacgttgga aataaagctg      120



ggcctcgtgt ctgcgcctgc atattcctac agcttcccag agtcctgtcg acaattactg      180



gggagacaaa ccatgcagga aacagcc                                          207





<210>  257

<211>  125

<212>  DNA

<213>  Homo sapiens



<400>  257

tcccaatgaa gaaactttca catgtcttac tctctgtcct agtcccagag cctgtaaagg       60



tgaaccactg ggactggctg ggggagaaga ggaagatttg ttccagaagg aactgtctga      120



gggat                                                                  125





<210>  258

<211>  67

<212>  DNA

<213>  Homo sapiens



<400>  258

ttcctatgat gaggaccttt tcacagacct gtactgagct ccgtgaggat aaataactct       60



gaggaga                                                                 67





<210>  259

<211>  75

<212>  DNA

<213>  Homo sapiens



<400>  259

ctacggggat gattttacga actgaactct ctctttctga tggattagtg gagaaaacag       60



aaaattctga gtagc                                                        75





<210>  260

<211>  72

<212>  DNA

<213>  Homo sapiens



<400>  260

actccatgat gaacacaaaa tgacaagcat atggctgaac tttcaagtga tgtcatctta       60



ctactgagaa gt                                                           72





<210>  261

<211>  75

<212>  DNA

<213>  Homo sapiens



<400>  261

gtcagatgat ttgaattgat aagctgatgt tctgtgaggt acaaaagtta atagcatgtt       60



agagttctga tggca                                                        75





<210>  262

<211>  65

<212>  DNA

<213>  Homo sapiens



<400>  262

tttctatgat gaatcaaact agctcactat gaccgacagt gaaaatacat gaacacctga       60



gaaac                                                                   65





<210>  263

<211>  70

<212>  DNA

<213>  Homo sapiens



<400>  263

gtttgtgatg acttacatgg aatctcgttc ggctgatgac ttgctgttga gactctgaaa       60



tctgattttc                                                              70





<210>  264

<211>  68

<212>  DNA

<213>  Homo sapiens



<400>  264

caccagtgat gagttgaata ccgccccagt ctgatcaatg tgtgactgaa aggtattttc       60



tgagctgt                                                                68





<210>  265

<211>  12227

<212>  DNA

<213>  Homo sapiens



<400>  265

tgagctgcga ggcccgagag tcagaacctg ggggagaggg atggtctctg cacggggggg       60



agccggagga gccgccgccg ctgccgacgc caccgccgca gccgccgccg ccgccgcccc      120



ggcacccgcc tcccggcgct gacggtctcg tacgaagccg gcgaggggga gccagcagcg      180



gcggtcgccg gcacgccgcc cagcatggtc cgggaaacca ggcatctctg ggtgggcaac      240



ttacccgaga acgtgcggga agagaagatc atcgagcatt tcaaacgata tggccgcgtg      300



gaaagtgtca aaattcttcc caagagggga tctgaaggag gagtggctgc ctttgtggat      360



tttgtggaca tcaaaagtgc acagaaagct cacaactcgg tcaacaaaat gggtgacaga      420



gacctacgca cggattataa tgaaccaggc accatcccga gtgctgctcg gggattggat      480



gatacagttt ccatagcatc tcgtagtaga gaggtttctg ggttcagagg aggtggtgga      540



gggcctgctt atggtccccc accgtcactt catgcacgag aaggacgtta tgagcggaga      600



cttgatgggg cttcagataa cagggagcgt gcttatgaac atagtgccta tggacaccat      660



gaacggggga cgggaggatt tgatcggaca agacattacg atcaggatta ctatagagat      720



cctcgagagc ggactttaca acatgggctc tattacgctt ctcggagtcg aagtccaaat      780



cgctttgatg ctcatgaccc ccgatatgaa cctagggctc gcgagcagtt tacactgccc      840



agtgtggtac acagggatat ctacagggat gatattaccc gggaggtacg aggcagaagg      900



ccagagcgga attaccagca cagcaggagt cggtcaccac attcatccca gtctagaaat      960



cagtctcctc agagactggc tagccaagca tctagaccca caaggtcccc tagcggcagc     1020



ggctctagaa gtagatcctc cagtagtgat tcaatcagca gcagcagtag taccagcagt     1080



gacagcagtg attccagcag tagttcaagt gatgattctc cagctcgatc agttcagtct     1140



gcagcagtcc ctgcacccac ttcccagttg ctttcatctc tggaaaaaga tgagccccgt     1200



aaaagttttg gcatcaaggt ccagaatctt ccagtacgct ctacagatac aagccttaaa     1260



gatggccttt tccatgaatt taagaaattt ggaaaagtaa cttcagtgca gatacatgga     1320



acttcagaag agaggtatgg tctggtattc tttcggcagc aagaggacca agaaaaagcc     1380



ttgactgcat caaaaggaaa acttttcttt ggcatgcaga ttgaagtaac agcatggata     1440



ggtccagaaa cagaaagtga aaatgaattt cgccccttgg atgaaaggat agatgaattt     1500



caccccaaag caacaagaac tctctttatt ggcaaccttg aaaaaaccac tacttaccat     1560



gaccttcgca acatcttcca gcgctttgga gaaattgtgg atattgacat taagaaagta     1620



aatggagttc ctcagtatgc gtttctgcaa tactgtgata ttgctagcgt ttgtaaagct     1680



attaagaaga tggatgggga atatcttgga aataatcgcc tcaagctggg ttttggaaag     1740



agcatgccta caaactgcgt gtggctagat gggctttctt cgaatgtgtc agatcagtat     1800



ttaacacgac atttctgccg atatgggcct gtggtaaagg tggtgtttga ccgcttaaaa     1860



ggcatggccc tggttctcta caatgaaatt gaatatgcac aagcagctgt aaaagagacc     1920



aaagggagga aaatcggtgg gaataaaatt aaggtggatt ttgcaaatcg ggaaagtcag     1980



ctggcttttt atcactgcat ggagaaatct ggtcaagaca tcagagactt ttatgaaatg     2040



ttagccgaaa gaagagagga acgaagggca tcctacgact ataaccaaga tcgtacatat     2100



tatgagagtg ttcgaactcc aggcacttat cctgaggatt ccaggcggga ctatccagct     2160



cgagggagag agttttattc agaatgggaa acttaccaag gagactacta tgaatcacga     2220



tactacgatg atcctcggga atacagggat tacaggaatg atccttatga acaagatatt     2280



agggaatata gttacaggca aagggaacga gaaagagaac gtgaaagatt tgagtctgac     2340



cgggacagag accatgagag gaggccgatt gaacgaagtc aaagtcctgt tcacttgcga     2400



cgtccacaga gtcctggagc gtctccctct caggcagaga ggttgccgag tgattctgag     2460



aggaggcttt acagccgatc ctcagaccgg agtggaagct gtagctcact ctcccctcca     2520



agatatgaga aactggacaa gtctcgtttg gagcgctata caaaaaatga aaagacagat     2580



aaagaacgaa cttttgatcc ggagagagtg gagagagaga gacgcttaat acggaaggaa     2640



aaagtggaaa aggacaaaac tgacaagcag aaacgcaaag gaaaggttca ctcccctagt     2700



tctcagtctt cagaaacgga ccaagaaaat gagcgagagc aaagccctga aaagcccagg     2760



agttgtaata aactgagcag agagaaagct gacaaagagg gaatagcgaa aaaccgcctg     2820



gaactcatgc cttgcgtggt tttgactcga gtgaaagaga aagagggaaa ggtcattgac     2880



cacactcctg tggaaaagtt gaaagccaag cttgataatg acactgtcaa atcttctgcc     2940



ctggaccaga aacttcaggt ctctcagacg gagcctgcaa aatctgactt gtctaaactg     3000



gaatcagtta gaatgaaagt accaaaggaa aaggggcttt caagccatgt tgaagtggtg     3060



gagaaggaag gcaggcttaa agccaggaag cacctcaagc ctgagcagcc tgcagatggg     3120



gtaagtgctg tggatctgga gaagctggaa gccaggaaaa ggcgctttgc agattccaat     3180



ttaaaagcag aaaagcaaaa accagaggtc aagaaaagca gtccagagat ggaggatgct     3240



cgcgtgcttt caaaaaagca gcctgacgtg tcctctagag aggtcattct gctgagggaa     3300



ggagaggctg aaagaaagcc tgtgaggaaa gaaattctta aaagagaatc taaaaaaatc     3360



aaactggaca gacttaatac tgttgccagc cccaaagact gtcaggagct tgccagtatt     3420



tctgttgggt ctggctcaag gcccagctca gacctacaag caagactggg agaactagca     3480



ggtgaatctg tggaaaatca agaagtccaa tcaaaaaagc ccattccctc aaaaccacag     3540



ctcaaacagc tgcaggtatt agatgatcaa ggaccagaga gagaagacgt taggaaaaac     3600



tattgcagtc ttcgtgatga aacacctgaa cgtaaatcag gccaagagaa atcacattca     3660



gtaaatactg aagaaaaaat tggcattgac atcgatcaca cgcagagtta ccgaaaacaa     3720



atggaacaga gtcgtaggaa acagcagatg gaaatggaaa tagccaagtc tgagaagttt     3780



ggcagtccta aaaaagatgt agatgaatat gaaagacgta gcctcgttca cgaggtaggc     3840



aaaccccctc aagatgtcac tgatgactct cctcctagca aaaagaaaag gatggatcat     3900



gtcgattttg atatctgcac caagcgagaa cggaattaca gaagttcacg ccaaatcagc     3960



gaagattctg aaaggactgg tggttctccc agtgtccgac atggttcctt ccatgaagat     4020



gaggatccca taggctcccc taggctactg tcagtaaaag ggtctcctaa agtagatgaa     4080



aaagtcctcc cctattctaa cataacagtc agggaagagt ctttaaaatt taatccttat     4140



gattctagca ggagagaaca gatggcagat atggccaaaa taaaactatc tgtcttgaat     4200



tctgaagatg aactaaatcg ttgggactct cagatgaaac aggatgctgg cagatttgat     4260



gtgagtttcc caaacagcat aattaagaga gatagccttc gaaaaaggtc tgtacgagat     4320



ctggaacctg gtgaggtgcc ttctgattct gacgaagatg gtgaacacaa atcccactca     4380



cccagagcct ctgcattata tgaaagttct cgattgtctt ttttattgag ggacagagaa     4440



gacaagctac gtgagcgaga tgaaagactc tctagttctt tagaaaggaa caaattttac     4500



tcttttgcat tggataagac aatcacacca gacactaaag ctttgcttga aagagctaaa     4560



tccctctctt catctcgtga agaaaattgg tcttttcttg attgggactc ccgatttgca     4620



aattttcgaa acaacaaaga taaagaaaag gttgactctg ctccaagacc tattccatcc     4680



tggtacatga aaaagaagaa aattaggact gattcagaag ggaaaatgga tgataagaaa     4740



gaggaccata aagaagaaga gcaagagagg caggaattgt ttgcttctcg ttttttacac     4800



agctcaatct ttgaacaaga ttccaagcga ttgcagcatc tagagagaaa agaggaagat     4860



tctgacttca tttctggtag gatctatggg aagcagacat ctgagggagc aaacagcaca     4920



actgattcca ttcaagaacc agtagttctg ttccatagca gatttatgga gctcacacgg     4980



atgcaacaga aagaaaaaga aaaagaccag aaacccaaag aggttgagaa acaggaagat     5040



acagagaatc atcccaagac cccagaatct gctcctgaga ataaagattc agaactgaaa     5100



actccacctt ccgttgggcc tccaagtgtc acagtcgtaa ctctagaatc agccccatca     5160



gcactagaga agaccactgg tgacaaaacg gtagaggcgc ctttggtaac agaagagaag     5220



actgtggagc cagctaccgt ctcagaagaa gcaaagcctg catctgaacc tgctcctgcc     5280



cctgtggaac agctggaaca agtagacctg cccccaggag cagaccccga taaagaagct     5340



gccatgatgc ctgcgggtgt tgaggaaggt tcatcaggtg accagccgcc ttatctggat     5400



gccaagcctc caactcccgg ggcctcgttt tcccaggcag agagcaacgt agatccagag     5460



cctgacagta cccagccact ttcaaaacca gctcagaagt ctgaggaagc caatgagcca     5520



aaggccgaaa agccagacgc cactgcagat gctgagcctg atgcaaacca gaaagccgaa     5580



gctgctcctg agtctcagcc cccagcttct gaagatttag aggttgatcc tccagttgct     5640



gcaaaggata aaaagccaaa caaaagcaag cgttcaaaga cccctgttca ggcagctgca     5700



gtgagtatcg tggagaagcc cgtcacaagg aagagtgaga ggatagaccg ggaaaaactc     5760



aagcggtcca attctcctcg gggagaagca cagaagcttt tggaattgaa gatggaggca     5820



gagaagatta caaggactgc ttctaaaaac tctgctgcag accttgaaca tcccgaacca     5880



agtttgcctc tcagccgaac aaggcgccgg aatgtaagga gcgtctatgc aaccatgggt     5940



gaccatgaaa accgctctcc tgtcaaagag cccgttgagc aaccaagagt gaccagaaag     6000



agattggagc gagagcttca ggaggctgca gcggttccca ccacccctcg gaggggaagg     6060



cctccaaaga cacgccggcg agccgatgaa gaggaggaga acgaggccaa ggaacctgca     6120



gaaacactca agccacctga gggatggcgg tcgccaaggt cccagaaaac tgcagctggt     6180



ggtggacccc aagggaaaaa gggaaaaaat gaaccgaagg tggatgctac acgtcctgag     6240



gccaccactg aggtgggccc ccaaataggc gtgaaagaga gctccatgga acccaaggct     6300



gctgaggagg aggcagggag tgaacagaaa cgtgacagaa aagatgctgg cacagacaaa     6360



aacccccctg aaaccgcccc tgttgaagtt gtagagaaaa aaccggcccc tgaaaaaaac     6420



tccaaatcaa agagaggaag atctcgaaac tccaggttag cagtggacaa atctgcaagt     6480



ctgaaaaatg tggatgctgc tgtcagtccc aggggggctg cagcacaggc aggggagagg     6540



gaatctgggg tggtggcagt ctcccctgag aaaagtgaga gtccccaaaa ggaggatggt     6600



ttatcatccc agttgaaaag tgatccagtt gatccagaca aggaaccaga gaaagaagac     6660



gtgtctgcct ctgggccgtc cccagaagcc acccagttag ccaagcagat ggagctggag     6720



caggccgtgg aacacatcgc aaagctcgct gaggcctctg cctctgctgc ctataaggca     6780



gatgcaccag agggccttgc cccagaggac agggacaagc ctgcacacca agcaagtgaa     6840



acagagctgg ctgcggccat cggctccatc atcaatgaca tttctgggga gccagaaaac     6900



ttcccagcac ctccacctta tcctggagaa tcccagacag atctgcaacc ccccgcaggt     6960



gcacaggcgc tgcagccttc tgaggaagga atggagacag atgaggctgt atctggcatc     7020



ctggaaactg aggctgctac agaatcttct aggcctccag tcaatgctcc tgacccctca     7080



gccggcccaa cagataccaa ggaagccaga ggaaatagca gtgaaacctc acactcagtg     7140



ccagaagcca aagggtctaa agaagtggaa gtcactcttg ttcggaaaga caaagggcgc     7200



cagaaaacaa cccgatcacg ccgcaagcga aacacaaaca agaaagtggt ggctcctgta     7260



gagagccatg tccctgaatc caaccaagct caaggtgaga gtcctgctgc aaatgagggg     7320



acaacagtac agcaccccga agccccacag gaagaaaagc agagtgagaa accccattcc     7380



actcctcctc agtcatgtac ttctgaccta agcaagattc cctccacaga gaattcgtcc     7440



caagaaatca gtgttgagga aaggactcca accaaagcat ctgtgccccc agaccttccc     7500



ccacctcccc agccagcacc ggtggatgag gagcctcaag ccaggttcag ggtgcattcc     7560



atcattgaaa gtgacccggt gaccccaccc agcgatccaa gcatccccat acccacactg     7620



ccttctgtaa ctgcagcaaa gctctcacct cctgtcgcct ctggggggat cccacaccag     7680



agccccccta ctaaggtgac agagtggatc acaaggcagg aggagccacg ggctcagtct     7740



actccatctc cagctcttcc cccagacaca aaggcctctg atgttgacac cagctccagc     7800



accctgagga agattctcat ggaccccaag tatgtgtctg ccacaagtgt cacttccaca     7860



agtgtcacca cagccattgc agagcctgtc agtgctgccc cttgcctaca tgaggccccg     7920



cccccgccag ttgactctaa aaagccttta gaagaaaaaa cagcacctcc agtgacaaac     7980



aactctgaga tacaagcctc ggaggtgctg gtagctgctg acaaggaaaa ggtggctcca     8040



gtcattgctc ccaaaattac ctctgttatt agccggatgc ctgtcagcat tgacctggaa     8100



aattcacaga agataacctt ggcaaaacca gctcctcaaa ccctcactgg tctggtgagc     8160



gcactcactg gcctggtgaa cgtctccctg gtcccggtga atgccctgaa aggccccgtg     8220



aagggctcag tgaccacact gaaaagtttg gtgagcaccc ctgctgggcc cgtgaacgtc     8280



ctgaaagggc ctgtgaatgt tcttacgggg ccagtgaatg ttctcaccac tccagtgaac     8340



gccacggtgg gcacagtgaa tgccgcccca ggcacagtca atgccgctgc gagtgcagtg     8400



aatgccacag caagtgcagt gaccgtcaca gcgggtgcgg ttactgctgc atctggtggt     8460



gtaacggcca caacaggcac ggtgacaatg gcaggggcag tgattgcgcc gtcaacaaag     8520



tgcaaacaga gagcgagtgc taatgaaaac agtcggttcc acccagggtc catgcctgtg     8580



atcgacgatc gtccggcaga cgcgggctca ggggcggggc tgcgtgtgaa cacttctgaa     8640



ggggttgtgc tcctgagtta ctcagggcag aagaccgaag gcccacagcg gatcagcgcc     8700



aagatcagcc agatcccccc ggccagtgca atggacattg aatttcagca gtcagtgtcc     8760



aagtcccagg tcaaacctga ttctgtcaca gcatcgcagc ctccatccaa aggccctcaa     8820



gctcctgcag gctatgcgaa cgtggccacc cattccacgt tggtactgac cgcccagaca     8880



tataatgcct ctcctgtgat ttcgtctgtg aaggccgata ggccatcctt ggagaagccc     8940



gagcccattc acctctcggt gtccacgcct gtcacccagg gaggcacagt gaaggttctc     9000



acccagggga tcaacacacc ccctgtgctg gttcacaacc agctggtcct caccccaagc     9060



attgtcacca caaacaagaa gcttgctgac cccgtcaccc ttaaaatcga gaccaaggtc     9120



cttcagccgg ccaacctggg gtccacgctc acgccccacc accctcctgc tctgcccagc     9180



aaactgccta cagaagtcaa ccatgtcccc tcggggccca gcatcccagc agatcgaact     9240



gtctcccatt tggcagctgc aaagctagat gctcattctc ctcgaccaag tggacccggg     9300



ccatcctcat tcccaagggc aagccacccc agcagtactg catctacggc gctctccacc     9360



aacgccacag tcatgctggc tgcaggcatc ccagtgcccc agttcatctc cagcatccac     9420



ccagagcagt ctgtcatcat gccaccccac agcatcaccc agactgtgtc cctgagccac     9480



ctctcccagg gcgaggtgag aatgaacact cccacgctgc ccagtatcac ctacagcatc     9540



cggccagaag cgcttcactc tcctcgggct ccgctgcagc cccagcaaat agaggtcagg     9600



gccccacagc gtgccagcac cccgcagcca gccccagctg gtgtgcctgc actggcctcc     9660



cagcaccctc ccgaggagga agtgcattat caccttcctg tcgctcgagc cacagcccct     9720



gtgcagtcag aggtactagt catgcagtct gagtaccgac tgcaccccta tactgtgcca     9780



cgggatgtga ggatcatggt gcatccacat gtgacggcag tcagcgagca gcccagggcc     9840



gcggatgggg tggtgaaggt gccaccagcc agcaaggccc ctcagcagcc agggaaggaa     9900



gctgccaaga caccagatgc caaagctgcc cccaccccca cccctgcccc cgtccctgtc     9960



cctgtccccc ttcctgcccc tgctcctgcc cctcatggtg aggcccgtat cctcacagtt    10020



acccccagta accaactcca ggggctgcct ctgacccctc ctgtggtggt gacccatggg    10080



gtgcagattg tgcactccag cggggagctg tttcaagagt accggtacgg cgacatccgc    10140



acctaccacc ccccggccca gctcacacac actcagtttc ccgccgcttc ctctgttggc    10200



ctgccttccc ggaccaagac agctgctcag ggccctcctc ctgaaggtga gcccctgcag    10260



cctcctcagc ctgtgcagtc cacacagcct gcccagcctg caccaccctg cccgccctcc    10320



cagctcggtc agcccggcca gccaccaagc agcaagatgc ctcaagtgtc ccaggaggca    10380



aaggggaccc agacgggagt agagcagcct cgcctcccag ctggacctgc aaacaggcca    10440



cctgagcctc acacccaggt tcagagggca caagcagaaa caggcccgac ttccttcccc    10500



tcccctgtgt ctgtctccat gaagcctgac cttccagtct ctcttcccac tcagactgcc    10560



ccaaaacagc cgttgtttgt cccaacaacc tctggcccca gcaccccacc aggactggtt    10620



ctgccacaca ctgaattcca gccagccccc aaacaagatt cctctccaca cctgacttcc    10680



cagagacccg tggatatggt tcaacttctg aagaagtacc ccatcgtgtg gcagggcctg    10740



ctggccctca agaatgacac agctgctgtg cagctccact tcgtctctgg caacaacgtc    10800



ctggcccatc ggtccctgcc cctttctgaa ggagggcccc cactaaggat cgcccagagg    10860



atgcggctgg aggcaacgca gctggaaggg gttgcccgaa ggatgacggt ggagacagat    10920



tactgtctgc tgctggctct gccctgtggc cgtgaccaag aggatgttgt gagccagacc    10980



gagtccctca aggctgcctt catcacttac ctgcaggcca agcaggcggc agggatcatc    11040



aacgttccca accctggctc caatcagcct gcctacgtgc tgcagatctt cccgccctgt    11100



gagttctctg agagtcacct gtcccgcctg gcccctgacc tccttgccag catctccaac    11160



atctctcccc acctcatgat tgtcattgcc tccgtgtgag ccactgagtg gttatcacct    11220



cagtgaatct tcccagggct ctgcagtaaa aacaaaggac aacccagcca agcagaggaa    11280



gaagctgccg aaggggacag actccactgc cagacggcca gccgtttgct gtcctgccgc    11340



ccggctcagt cggccagact tcctctagga gtggtgctgc taccttgtat gtttacataa    11400



tgctttagcc caaggacaca tcaccaaccc atggactcgc agacaccggg gctgggtttc    11460



tctttcctct ttttggagaa aaggaacagg gcagtggaat gaaaattttt tgtttgtttg    11520



tttttaagaa acaagaaaac agaactgcct ttgcactaaa ttagtgactt ggacttttgc    11580



ccagtgaaga caggctgtga cactctggat gtcttggtgt gtgtagacac acattgcaga    11640



ctcttaacgc aggaaggact tcaaacttct gctgagacct tggggtcaag gaacatttca    11700



ttggtttttt ttgtccaccc ccatctccct tgctcatttg gatgcgtcac cttaattctc    11760



ctgctgccac cgtctttgat tcaccgggat gtacagttta cagttgaaga gcaaacagaa    11820



aggttttctc ttggtgggat atgcagaact tgggatgtgt gtatatataa atatataata    11880



tatataaata tatataatac tgacttaaaa aatcaaatcc cccgacatac gtttttttta    11940



atctgtgcca aaaatgtgtt ttcagaggaa atcttatttt catattcaga ctttgtattg    12000



cccactcatt tgtataagtg cgcttcggta cagcacgggt cctgctcccg cgatgtggaa    12060



gtgtcacacg gcacctgtac aaaaagactg gctaacccct cttcctatta ccttgatctc    12120



ttcccccaac ttcctaacac ttattaattt atgaaactgt ttttctcagc gcagttttgt    12180



tttgtgtgtc cattggatta caaactttat taaaaaatat aaaacac                  12227





<210>  266

<211>  3664

<212>  PRT

<213>  Homo sapiens



<400>  266



Met Val Arg Glu Thr Arg His Leu Trp Val Gly Asn Leu Pro Glu Asn 

1               5                   10                  15      





Val Arg Glu Glu Lys Ile Ile Glu His Phe Lys Arg Tyr Gly Arg Val 

            20                  25                  30          





Glu Ser Val Lys Ile Leu Pro Lys Arg Gly Ser Glu Gly Gly Val Ala 

        35                  40                  45              





Ala Phe Val Asp Phe Val Asp Ile Lys Ser Ala Gln Lys Ala His Asn 

    50                  55                  60                  





Ser Val Asn Lys Met Gly Asp Arg Asp Leu Arg Thr Asp Tyr Asn Glu 

65                  70                  75                  80  





Pro Gly Thr Ile Pro Ser Ala Ala Arg Gly Leu Asp Asp Thr Val Ser 

                85                  90                  95      





Ile Ala Ser Arg Ser Arg Glu Val Ser Gly Phe Arg Gly Gly Gly Gly 

            100                 105                 110         





Gly Pro Ala Tyr Gly Pro Pro Pro Ser Leu His Ala Arg Glu Gly Arg 

        115                 120                 125             





Tyr Glu Arg Arg Leu Asp Gly Ala Ser Asp Asn Arg Glu Arg Ala Tyr 

    130                 135                 140                 





Glu His Ser Ala Tyr Gly His His Glu Arg Gly Thr Gly Gly Phe Asp 

145                 150                 155                 160 





Arg Thr Arg His Tyr Asp Gln Asp Tyr Tyr Arg Asp Pro Arg Glu Arg 

                165                 170                 175     





Thr Leu Gln His Gly Leu Tyr Tyr Ala Ser Arg Ser Arg Ser Pro Asn 

            180                 185                 190         





Arg Phe Asp Ala His Asp Pro Arg Tyr Glu Pro Arg Ala Arg Glu Gln 

        195                 200                 205             





Phe Thr Leu Pro Ser Val Val His Arg Asp Ile Tyr Arg Asp Asp Ile 

    210                 215                 220                 





Thr Arg Glu Val Arg Gly Arg Arg Pro Glu Arg Asn Tyr Gln His Ser 

225                 230                 235                 240 





Arg Ser Arg Ser Pro His Ser Ser Gln Ser Arg Asn Gln Ser Pro Gln 

                245                 250                 255     





Arg Leu Ala Ser Gln Ala Ser Arg Pro Thr Arg Ser Pro Ser Gly Ser 

            260                 265                 270         





Gly Ser Arg Ser Arg Ser Ser Ser Ser Asp Ser Ile Ser Ser Ser Ser 

        275                 280                 285             





Ser Thr Ser Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Ser Asp Asp 

    290                 295                 300                 





Ser Pro Ala Arg Ser Val Gln Ser Ala Ala Val Pro Ala Pro Thr Ser 

305                 310                 315                 320 





Gln Leu Leu Ser Ser Leu Glu Lys Asp Glu Pro Arg Lys Ser Phe Gly 

                325                 330                 335     





Ile Lys Val Gln Asn Leu Pro Val Arg Ser Thr Asp Thr Ser Leu Lys 

            340                 345                 350         





Asp Gly Leu Phe His Glu Phe Lys Lys Phe Gly Lys Val Thr Ser Val 

        355                 360                 365             





Gln Ile His Gly Thr Ser Glu Glu Arg Tyr Gly Leu Val Phe Phe Arg 

    370                 375                 380                 





Gln Gln Glu Asp Gln Glu Lys Ala Leu Thr Ala Ser Lys Gly Lys Leu 

385                 390                 395                 400 





Phe Phe Gly Met Gln Ile Glu Val Thr Ala Trp Ile Gly Pro Glu Thr 

                405                 410                 415     





Glu Ser Glu Asn Glu Phe Arg Pro Leu Asp Glu Arg Ile Asp Glu Phe 

            420                 425                 430         





His Pro Lys Ala Thr Arg Thr Leu Phe Ile Gly Asn Leu Glu Lys Thr 

        435                 440                 445             





Thr Thr Tyr His Asp Leu Arg Asn Ile Phe Gln Arg Phe Gly Glu Ile 

    450                 455                 460                 





Val Asp Ile Asp Ile Lys Lys Val Asn Gly Val Pro Gln Tyr Ala Phe 

465                 470                 475                 480 





Leu Gln Tyr Cys Asp Ile Ala Ser Val Cys Lys Ala Ile Lys Lys Met 

                485                 490                 495     





Asp Gly Glu Tyr Leu Gly Asn Asn Arg Leu Lys Leu Gly Phe Gly Lys 

            500                 505                 510         





Ser Met Pro Thr Asn Cys Val Trp Leu Asp Gly Leu Ser Ser Asn Val 

        515                 520                 525             





Ser Asp Gln Tyr Leu Thr Arg His Phe Cys Arg Tyr Gly Pro Val Val 

    530                 535                 540                 





Lys Val Val Phe Asp Arg Leu Lys Gly Met Ala Leu Val Leu Tyr Asn 

545                 550                 555                 560 





Glu Ile Glu Tyr Ala Gln Ala Ala Val Lys Glu Thr Lys Gly Arg Lys 

                565                 570                 575     





Ile Gly Gly Asn Lys Ile Lys Val Asp Phe Ala Asn Arg Glu Ser Gln 

            580                 585                 590         





Leu Ala Phe Tyr His Cys Met Glu Lys Ser Gly Gln Asp Ile Arg Asp 

        595                 600                 605             





Phe Tyr Glu Met Leu Ala Glu Arg Arg Glu Glu Arg Arg Ala Ser Tyr 

    610                 615                 620                 





Asp Tyr Asn Gln Asp Arg Thr Tyr Tyr Glu Ser Val Arg Thr Pro Gly 

625                 630                 635                 640 





Thr Tyr Pro Glu Asp Ser Arg Arg Asp Tyr Pro Ala Arg Gly Arg Glu 

                645                 650                 655     





Phe Tyr Ser Glu Trp Glu Thr Tyr Gln Gly Asp Tyr Tyr Glu Ser Arg 

            660                 665                 670         





Tyr Tyr Asp Asp Pro Arg Glu Tyr Arg Asp Tyr Arg Asn Asp Pro Tyr 

        675                 680                 685             





Glu Gln Asp Ile Arg Glu Tyr Ser Tyr Arg Gln Arg Glu Arg Glu Arg 

    690                 695                 700                 





Glu Arg Glu Arg Phe Glu Ser Asp Arg Asp Arg Asp His Glu Arg Arg 

705                 710                 715                 720 





Pro Ile Glu Arg Ser Gln Ser Pro Val His Leu Arg Arg Pro Gln Ser 

                725                 730                 735     





Pro Gly Ala Ser Pro Ser Gln Ala Glu Arg Leu Pro Ser Asp Ser Glu 

            740                 745                 750         





Arg Arg Leu Tyr Ser Arg Ser Ser Asp Arg Ser Gly Ser Cys Ser Ser 

        755                 760                 765             





Leu Ser Pro Pro Arg Tyr Glu Lys Leu Asp Lys Ser Arg Leu Glu Arg 

    770                 775                 780                 





Tyr Thr Lys Asn Glu Lys Thr Asp Lys Glu Arg Thr Phe Asp Pro Glu 

785                 790                 795                 800 





Arg Val Glu Arg Glu Arg Arg Leu Ile Arg Lys Glu Lys Val Glu Lys 

                805                 810                 815     





Asp Lys Thr Asp Lys Gln Lys Arg Lys Gly Lys Val His Ser Pro Ser 

            820                 825                 830         





Ser Gln Ser Ser Glu Thr Asp Gln Glu Asn Glu Arg Glu Gln Ser Pro 

        835                 840                 845             





Glu Lys Pro Arg Ser Cys Asn Lys Leu Ser Arg Glu Lys Ala Asp Lys 

    850                 855                 860                 





Glu Gly Ile Ala Lys Asn Arg Leu Glu Leu Met Pro Cys Val Val Leu 

865                 870                 875                 880 





Thr Arg Val Lys Glu Lys Glu Gly Lys Val Ile Asp His Thr Pro Val 

                885                 890                 895     





Glu Lys Leu Lys Ala Lys Leu Asp Asn Asp Thr Val Lys Ser Ser Ala 

            900                 905                 910         





Leu Asp Gln Lys Leu Gln Val Ser Gln Thr Glu Pro Ala Lys Ser Asp 

        915                 920                 925             





Leu Ser Lys Leu Glu Ser Val Arg Met Lys Val Pro Lys Glu Lys Gly 

    930                 935                 940                 





Leu Ser Ser His Val Glu Val Val Glu Lys Glu Gly Arg Leu Lys Ala 

945                 950                 955                 960 





Arg Lys His Leu Lys Pro Glu Gln Pro Ala Asp Gly Val Ser Ala Val 

                965                 970                 975     





Asp Leu Glu Lys Leu Glu Ala Arg Lys Arg Arg Phe Ala Asp Ser Asn 

            980                 985                 990         





Leu Lys Ala Glu Lys Gln Lys Pro  Glu Val Lys Lys Ser  Ser Pro Glu 

        995                 1000                 1005             





Met Glu  Asp Ala Arg Val Leu  Ser Lys Lys Gln Pro  Asp Val Ser 

    1010                 1015                 1020             





Ser Arg  Glu Val Ile Leu Leu  Arg Glu Gly Glu Ala  Glu Arg Lys 

    1025                 1030                 1035             





Pro Val  Arg Lys Glu Ile Leu  Lys Arg Glu Ser Lys  Lys Ile Lys 

    1040                 1045                 1050             





Leu Asp  Arg Leu Asn Thr Val  Ala Ser Pro Lys Asp  Cys Gln Glu 

    1055                 1060                 1065             





Leu Ala  Ser Ile Ser Val Gly  Ser Gly Ser Arg Pro  Ser Ser Asp 

    1070                 1075                 1080             





Leu Gln  Ala Arg Leu Gly Glu  Leu Ala Gly Glu Ser  Val Glu Asn 

    1085                 1090                 1095             





Gln Glu  Val Gln Ser Lys Lys  Pro Ile Pro Ser Lys  Pro Gln Leu 

    1100                 1105                 1110             





Lys Gln  Leu Gln Val Leu Asp  Asp Gln Gly Pro Glu  Arg Glu Asp 

    1115                 1120                 1125             





Val Arg  Lys Asn Tyr Cys Ser  Leu Arg Asp Glu Thr  Pro Glu Arg 

    1130                 1135                 1140             





Lys Ser  Gly Gln Glu Lys Ser  His Ser Val Asn Thr  Glu Glu Lys 

    1145                 1150                 1155             





Ile Gly  Ile Asp Ile Asp His  Thr Gln Ser Tyr Arg  Lys Gln Met 

    1160                 1165                 1170             





Glu Gln  Ser Arg Arg Lys Gln  Gln Met Glu Met Glu  Ile Ala Lys 

    1175                 1180                 1185             





Ser Glu  Lys Phe Gly Ser Pro  Lys Lys Asp Val Asp  Glu Tyr Glu 

    1190                 1195                 1200             





Arg Arg  Ser Leu Val His Glu  Val Gly Lys Pro Pro  Gln Asp Val 

    1205                 1210                 1215             





Thr Asp  Asp Ser Pro Pro Ser  Lys Lys Lys Arg Met  Asp His Val 

    1220                 1225                 1230             





Asp Phe  Asp Ile Cys Thr Lys  Arg Glu Arg Asn Tyr  Arg Ser Ser 

    1235                 1240                 1245             





Arg Gln  Ile Ser Glu Asp Ser  Glu Arg Thr Gly Gly  Ser Pro Ser 

    1250                 1255                 1260             





Val Arg  His Gly Ser Phe His  Glu Asp Glu Asp Pro  Ile Gly Ser 

    1265                 1270                 1275             





Pro Arg  Leu Leu Ser Val Lys  Gly Ser Pro Lys Val  Asp Glu Lys 

    1280                 1285                 1290             





Val Leu  Pro Tyr Ser Asn Ile  Thr Val Arg Glu Glu  Ser Leu Lys 

    1295                 1300                 1305             





Phe Asn  Pro Tyr Asp Ser Ser  Arg Arg Glu Gln Met  Ala Asp Met 

    1310                 1315                 1320             





Ala Lys  Ile Lys Leu Ser Val  Leu Asn Ser Glu Asp  Glu Leu Asn 

    1325                 1330                 1335             





Arg Trp  Asp Ser Gln Met Lys  Gln Asp Ala Gly Arg  Phe Asp Val 

    1340                 1345                 1350             





Ser Phe  Pro Asn Ser Ile Ile  Lys Arg Asp Ser Leu  Arg Lys Arg 

    1355                 1360                 1365             





Ser Val  Arg Asp Leu Glu Pro  Gly Glu Val Pro Ser  Asp Ser Asp 

    1370                 1375                 1380             





Glu Asp  Gly Glu His Lys Ser  His Ser Pro Arg Ala  Ser Ala Leu 

    1385                 1390                 1395             





Tyr Glu  Ser Ser Arg Leu Ser  Phe Leu Leu Arg Asp  Arg Glu Asp 

    1400                 1405                 1410             





Lys Leu  Arg Glu Arg Asp Glu  Arg Leu Ser Ser Ser  Leu Glu Arg 

    1415                 1420                 1425             





Asn Lys  Phe Tyr Ser Phe Ala  Leu Asp Lys Thr Ile  Thr Pro Asp 

    1430                 1435                 1440             





Thr Lys  Ala Leu Leu Glu Arg  Ala Lys Ser Leu Ser  Ser Ser Arg 

    1445                 1450                 1455             





Glu Glu  Asn Trp Ser Phe Leu  Asp Trp Asp Ser Arg  Phe Ala Asn 

    1460                 1465                 1470             





Phe Arg  Asn Asn Lys Asp Lys  Glu Lys Val Asp Ser  Ala Pro Arg 

    1475                 1480                 1485             





Pro Ile  Pro Ser Trp Tyr Met  Lys Lys Lys Lys Ile  Arg Thr Asp 

    1490                 1495                 1500             





Ser Glu  Gly Lys Met Asp Asp  Lys Lys Glu Asp His  Lys Glu Glu 

    1505                 1510                 1515             





Glu Gln  Glu Arg Gln Glu Leu  Phe Ala Ser Arg Phe  Leu His Ser 

    1520                 1525                 1530             





Ser Ile  Phe Glu Gln Asp Ser  Lys Arg Leu Gln His  Leu Glu Arg 

    1535                 1540                 1545             





Lys Glu  Glu Asp Ser Asp Phe  Ile Ser Gly Arg Ile  Tyr Gly Lys 

    1550                 1555                 1560             





Gln Thr  Ser Glu Gly Ala Asn  Ser Thr Thr Asp Ser  Ile Gln Glu 

    1565                 1570                 1575             





Pro Val  Val Leu Phe His Ser  Arg Phe Met Glu Leu  Thr Arg Met 

    1580                 1585                 1590             





Gln Gln  Lys Glu Lys Glu Lys  Asp Gln Lys Pro Lys  Glu Val Glu 

    1595                 1600                 1605             





Lys Gln  Glu Asp Thr Glu Asn  His Pro Lys Thr Pro  Glu Ser Ala 

    1610                 1615                 1620             





Pro Glu  Asn Lys Asp Ser Glu  Leu Lys Thr Pro Pro  Ser Val Gly 

    1625                 1630                 1635             





Pro Pro  Ser Val Thr Val Val  Thr Leu Glu Ser Ala  Pro Ser Ala 

    1640                 1645                 1650             





Leu Glu  Lys Thr Thr Gly Asp  Lys Thr Val Glu Ala  Pro Leu Val 

    1655                 1660                 1665             





Thr Glu  Glu Lys Thr Val Glu  Pro Ala Thr Val Ser  Glu Glu Ala 

    1670                 1675                 1680             





Lys Pro  Ala Ser Glu Pro Ala  Pro Ala Pro Val Glu  Gln Leu Glu 

    1685                 1690                 1695             





Gln Val  Asp Leu Pro Pro Gly  Ala Asp Pro Asp Lys  Glu Ala Ala 

    1700                 1705                 1710             





Met Met  Pro Ala Gly Val Glu  Glu Gly Ser Ser Gly  Asp Gln Pro 

    1715                 1720                 1725             





Pro Tyr  Leu Asp Ala Lys Pro  Pro Thr Pro Gly Ala  Ser Phe Ser 

    1730                 1735                 1740             





Gln Ala  Glu Ser Asn Val Asp  Pro Glu Pro Asp Ser  Thr Gln Pro 

    1745                 1750                 1755             





Leu Ser  Lys Pro Ala Gln Lys  Ser Glu Glu Ala Asn  Glu Pro Lys 

    1760                 1765                 1770             





Ala Glu  Lys Pro Asp Ala Thr  Ala Asp Ala Glu Pro  Asp Ala Asn 

    1775                 1780                 1785             





Gln Lys  Ala Glu Ala Ala Pro  Glu Ser Gln Pro Pro  Ala Ser Glu 

    1790                 1795                 1800             





Asp Leu  Glu Val Asp Pro Pro  Val Ala Ala Lys Asp  Lys Lys Pro 

    1805                 1810                 1815             





Asn Lys  Ser Lys Arg Ser Lys  Thr Pro Val Gln Ala  Ala Ala Val 

    1820                 1825                 1830             





Ser Ile  Val Glu Lys Pro Val  Thr Arg Lys Ser Glu  Arg Ile Asp 

    1835                 1840                 1845             





Arg Glu  Lys Leu Lys Arg Ser  Asn Ser Pro Arg Gly  Glu Ala Gln 

    1850                 1855                 1860             





Lys Leu  Leu Glu Leu Lys Met  Glu Ala Glu Lys Ile  Thr Arg Thr 

    1865                 1870                 1875             





Ala Ser  Lys Asn Ser Ala Ala  Asp Leu Glu His Pro  Glu Pro Ser 

    1880                 1885                 1890             





Leu Pro  Leu Ser Arg Thr Arg  Arg Arg Asn Val Arg  Ser Val Tyr 

    1895                 1900                 1905             





Ala Thr  Met Gly Asp His Glu  Asn Arg Ser Pro Val  Lys Glu Pro 

    1910                 1915                 1920             





Val Glu  Gln Pro Arg Val Thr  Arg Lys Arg Leu Glu  Arg Glu Leu 

    1925                 1930                 1935             





Gln Glu  Ala Ala Ala Val Pro  Thr Thr Pro Arg Arg  Gly Arg Pro 

    1940                 1945                 1950             





Pro Lys  Thr Arg Arg Arg Ala  Asp Glu Glu Glu Glu  Asn Glu Ala 

    1955                 1960                 1965             





Lys Glu  Pro Ala Glu Thr Leu  Lys Pro Pro Glu Gly  Trp Arg Ser 

    1970                 1975                 1980             





Pro Arg  Ser Gln Lys Thr Ala  Ala Gly Gly Gly Pro  Gln Gly Lys 

    1985                 1990                 1995             





Lys Gly  Lys Asn Glu Pro Lys  Val Asp Ala Thr Arg  Pro Glu Ala 

    2000                 2005                 2010             





Thr Thr  Glu Val Gly Pro Gln  Ile Gly Val Lys Glu  Ser Ser Met 

    2015                 2020                 2025             





Glu Pro  Lys Ala Ala Glu Glu  Glu Ala Gly Ser Glu  Gln Lys Arg 

    2030                 2035                 2040             





Asp Arg  Lys Asp Ala Gly Thr  Asp Lys Asn Pro Pro  Glu Thr Ala 

    2045                 2050                 2055             





Pro Val  Glu Val Val Glu Lys  Lys Pro Ala Pro Glu  Lys Asn Ser 

    2060                 2065                 2070             





Lys Ser  Lys Arg Gly Arg Ser  Arg Asn Ser Arg Leu  Ala Val Asp 

    2075                 2080                 2085             





Lys Ser  Ala Ser Leu Lys Asn  Val Asp Ala Ala Val  Ser Pro Arg 

    2090                 2095                 2100             





Gly Ala  Ala Ala Gln Ala Gly  Glu Arg Glu Ser Gly  Val Val Ala 

    2105                 2110                 2115             





Val Ser  Pro Glu Lys Ser Glu  Ser Pro Gln Lys Glu  Asp Gly Leu 

    2120                 2125                 2130             





Ser Ser  Gln Leu Lys Ser Asp  Pro Val Asp Pro Asp  Lys Glu Pro 

    2135                 2140                 2145             





Glu Lys  Glu Asp Val Ser Ala  Ser Gly Pro Ser Pro  Glu Ala Thr 

    2150                 2155                 2160             





Gln Leu  Ala Lys Gln Met Glu  Leu Glu Gln Ala Val  Glu His Ile 

    2165                 2170                 2175             





Ala Lys  Leu Ala Glu Ala Ser  Ala Ser Ala Ala Tyr  Lys Ala Asp 

    2180                 2185                 2190             





Ala Pro  Glu Gly Leu Ala Pro  Glu Asp Arg Asp Lys  Pro Ala His 

    2195                 2200                 2205             





Gln Ala  Ser Glu Thr Glu Leu  Ala Ala Ala Ile Gly  Ser Ile Ile 

    2210                 2215                 2220             





Asn Asp  Ile Ser Gly Glu Pro  Glu Asn Phe Pro Ala  Pro Pro Pro 

    2225                 2230                 2235             





Tyr Pro  Gly Glu Ser Gln Thr  Asp Leu Gln Pro Pro  Ala Gly Ala 

    2240                 2245                 2250             





Gln Ala  Leu Gln Pro Ser Glu  Glu Gly Met Glu Thr  Asp Glu Ala 

    2255                 2260                 2265             





Val Ser  Gly Ile Leu Glu Thr  Glu Ala Ala Thr Glu  Ser Ser Arg 

    2270                 2275                 2280             





Pro Pro  Val Asn Ala Pro Asp  Pro Ser Ala Gly Pro  Thr Asp Thr 

    2285                 2290                 2295             





Lys Glu  Ala Arg Gly Asn Ser  Ser Glu Thr Ser His  Ser Val Pro 

    2300                 2305                 2310             





Glu Ala  Lys Gly Ser Lys Glu  Val Glu Val Thr Leu  Val Arg Lys 

    2315                 2320                 2325             





Asp Lys  Gly Arg Gln Lys Thr  Thr Arg Ser Arg Arg  Lys Arg Asn 

    2330                 2335                 2340             





Thr Asn  Lys Lys Val Val Ala  Pro Val Glu Ser His  Val Pro Glu 

    2345                 2350                 2355             





Ser Asn  Gln Ala Gln Gly Glu  Ser Pro Ala Ala Asn  Glu Gly Thr 

    2360                 2365                 2370             





Thr Val  Gln His Pro Glu Ala  Pro Gln Glu Glu Lys  Gln Ser Glu 

    2375                 2380                 2385             





Lys Pro  His Ser Thr Pro Pro  Gln Ser Cys Thr Ser  Asp Leu Ser 

    2390                 2395                 2400             





Lys Ile  Pro Ser Thr Glu Asn  Ser Ser Gln Glu Ile  Ser Val Glu 

    2405                 2410                 2415             





Glu Arg  Thr Pro Thr Lys Ala  Ser Val Pro Pro Asp  Leu Pro Pro 

    2420                 2425                 2430             





Pro Pro  Gln Pro Ala Pro Val  Asp Glu Glu Pro Gln  Ala Arg Phe 

    2435                 2440                 2445             





Arg Val  His Ser Ile Ile Glu  Ser Asp Pro Val Thr  Pro Pro Ser 

    2450                 2455                 2460             





Asp Pro  Ser Ile Pro Ile Pro  Thr Leu Pro Ser Val  Thr Ala Ala 

    2465                 2470                 2475             





Lys Leu  Ser Pro Pro Val Ala  Ser Gly Gly Ile Pro  His Gln Ser 

    2480                 2485                 2490             





Pro Pro  Thr Lys Val Thr Glu  Trp Ile Thr Arg Gln  Glu Glu Pro 

    2495                 2500                 2505             





Arg Ala  Gln Ser Thr Pro Ser  Pro Ala Leu Pro Pro  Asp Thr Lys 

    2510                 2515                 2520             





Ala Ser  Asp Val Asp Thr Ser  Ser Ser Thr Leu Arg  Lys Ile Leu 

    2525                 2530                 2535             





Met Asp  Pro Lys Tyr Val Ser  Ala Thr Ser Val Thr  Ser Thr Ser 

    2540                 2545                 2550             





Val Thr  Thr Ala Ile Ala Glu  Pro Val Ser Ala Ala  Pro Cys Leu 

    2555                 2560                 2565             





His Glu  Ala Pro Pro Pro Pro  Val Asp Ser Lys Lys  Pro Leu Glu 

    2570                 2575                 2580             





Glu Lys  Thr Ala Pro Pro Val  Thr Asn Asn Ser Glu  Ile Gln Ala 

    2585                 2590                 2595             





Ser Glu  Val Leu Val Ala Ala  Asp Lys Glu Lys Val  Ala Pro Val 

    2600                 2605                 2610             





Ile Ala  Pro Lys Ile Thr Ser  Val Ile Ser Arg Met  Pro Val Ser 

    2615                 2620                 2625             





Ile Asp  Leu Glu Asn Ser Gln  Lys Ile Thr Leu Ala  Lys Pro Ala 

    2630                 2635                 2640             





Pro Gln  Thr Leu Thr Gly Leu  Val Ser Ala Leu Thr  Gly Leu Val 

    2645                 2650                 2655             





Asn Val  Ser Leu Val Pro Val  Asn Ala Leu Lys Gly  Pro Val Lys 

    2660                 2665                 2670             





Gly Ser  Val Thr Thr Leu Lys  Ser Leu Val Ser Thr  Pro Ala Gly 

    2675                 2680                 2685             





Pro Val  Asn Val Leu Lys Gly  Pro Val Asn Val Leu  Thr Gly Pro 

    2690                 2695                 2700             





Val Asn  Val Leu Thr Thr Pro  Val Asn Ala Thr Val  Gly Thr Val 

    2705                 2710                 2715             





Asn Ala  Ala Pro Gly Thr Val  Asn Ala Ala Ala Ser  Ala Val Asn 

    2720                 2725                 2730             





Ala Thr  Ala Ser Ala Val Thr  Val Thr Ala Gly Ala  Val Thr Ala 

    2735                 2740                 2745             





Ala Ser  Gly Gly Val Thr Ala  Thr Thr Gly Thr Val  Thr Met Ala 

    2750                 2755                 2760             





Gly Ala  Val Ile Ala Pro Ser  Thr Lys Cys Lys Gln  Arg Ala Ser 

    2765                 2770                 2775             





Ala Asn  Glu Asn Ser Arg Phe  His Pro Gly Ser Met  Pro Val Ile 

    2780                 2785                 2790             





Asp Asp  Arg Pro Ala Asp Ala  Gly Ser Gly Ala Gly  Leu Arg Val 

    2795                 2800                 2805             





Asn Thr  Ser Glu Gly Val Val  Leu Leu Ser Tyr Ser  Gly Gln Lys 

    2810                 2815                 2820             





Thr Glu  Gly Pro Gln Arg Ile  Ser Ala Lys Ile Ser  Gln Ile Pro 

    2825                 2830                 2835             





Pro Ala  Ser Ala Met Asp Ile  Glu Phe Gln Gln Ser  Val Ser Lys 

    2840                 2845                 2850             





Ser Gln  Val Lys Pro Asp Ser  Val Thr Ala Ser Gln  Pro Pro Ser 

    2855                 2860                 2865             





Lys Gly  Pro Gln Ala Pro Ala  Gly Tyr Ala Asn Val  Ala Thr His 

    2870                 2875                 2880             





Ser Thr  Leu Val Leu Thr Ala  Gln Thr Tyr Asn Ala  Ser Pro Val 

    2885                 2890                 2895             





Ile Ser  Ser Val Lys Ala Asp  Arg Pro Ser Leu Glu  Lys Pro Glu 

    2900                 2905                 2910             





Pro Ile  His Leu Ser Val Ser  Thr Pro Val Thr Gln  Gly Gly Thr 

    2915                 2920                 2925             





Val Lys  Val Leu Thr Gln Gly  Ile Asn Thr Pro Pro  Val Leu Val 

    2930                 2935                 2940             





His Asn  Gln Leu Val Leu Thr  Pro Ser Ile Val Thr  Thr Asn Lys 

    2945                 2950                 2955             





Lys Leu  Ala Asp Pro Val Thr  Leu Lys Ile Glu Thr  Lys Val Leu 

    2960                 2965                 2970             





Gln Pro  Ala Asn Leu Gly Ser  Thr Leu Thr Pro His  His Pro Pro 

    2975                 2980                 2985             





Ala Leu  Pro Ser Lys Leu Pro  Thr Glu Val Asn His  Val Pro Ser 

    2990                 2995                 3000             





Gly Pro  Ser Ile Pro Ala Asp  Arg Thr Val Ser His  Leu Ala Ala 

    3005                 3010                 3015             





Ala Lys  Leu Asp Ala His Ser  Pro Arg Pro Ser Gly  Pro Gly Pro 

    3020                 3025                 3030             





Ser Ser  Phe Pro Arg Ala Ser  His Pro Ser Ser Thr  Ala Ser Thr 

    3035                 3040                 3045             





Ala Leu  Ser Thr Asn Ala Thr  Val Met Leu Ala Ala  Gly Ile Pro 

    3050                 3055                 3060             





Val Pro  Gln Phe Ile Ser Ser  Ile His Pro Glu Gln  Ser Val Ile 

    3065                 3070                 3075             





Met Pro  Pro His Ser Ile Thr  Gln Thr Val Ser Leu  Ser His Leu 

    3080                 3085                 3090             





Ser Gln  Gly Glu Val Arg Met  Asn Thr Pro Thr Leu  Pro Ser Ile 

    3095                 3100                 3105             





Thr Tyr  Ser Ile Arg Pro Glu  Ala Leu His Ser Pro  Arg Ala Pro 

    3110                 3115                 3120             





Leu Gln  Pro Gln Gln Ile Glu  Val Arg Ala Pro Gln  Arg Ala Ser 

    3125                 3130                 3135             





Thr Pro  Gln Pro Ala Pro Ala  Gly Val Pro Ala Leu  Ala Ser Gln 

    3140                 3145                 3150             





His Pro  Pro Glu Glu Glu Val  His Tyr His Leu Pro  Val Ala Arg 

    3155                 3160                 3165             





Ala Thr  Ala Pro Val Gln Ser  Glu Val Leu Val Met  Gln Ser Glu 

    3170                 3175                 3180             





Tyr Arg  Leu His Pro Tyr Thr  Val Pro Arg Asp Val  Arg Ile Met 

    3185                 3190                 3195             





Val His  Pro His Val Thr Ala  Val Ser Glu Gln Pro  Arg Ala Ala 

    3200                 3205                 3210             





Asp Gly  Val Val Lys Val Pro  Pro Ala Ser Lys Ala  Pro Gln Gln 

    3215                 3220                 3225             





Pro Gly  Lys Glu Ala Ala Lys  Thr Pro Asp Ala Lys  Ala Ala Pro 

    3230                 3235                 3240             





Thr Pro  Thr Pro Ala Pro Val  Pro Val Pro Val Pro  Leu Pro Ala 

    3245                 3250                 3255             





Pro Ala  Pro Ala Pro His Gly  Glu Ala Arg Ile Leu  Thr Val Thr 

    3260                 3265                 3270             





Pro Ser  Asn Gln Leu Gln Gly  Leu Pro Leu Thr Pro  Pro Val Val 

    3275                 3280                 3285             





Val Thr  His Gly Val Gln Ile  Val His Ser Ser Gly  Glu Leu Phe 

    3290                 3295                 3300             





Gln Glu  Tyr Arg Tyr Gly Asp  Ile Arg Thr Tyr His  Pro Pro Ala 

    3305                 3310                 3315             





Gln Leu  Thr His Thr Gln Phe  Pro Ala Ala Ser Ser  Val Gly Leu 

    3320                 3325                 3330             





Pro Ser  Arg Thr Lys Thr Ala  Ala Gln Gly Pro Pro  Pro Glu Gly 

    3335                 3340                 3345             





Glu Pro  Leu Gln Pro Pro Gln  Pro Val Gln Ser Thr  Gln Pro Ala 

    3350                 3355                 3360             





Gln Pro  Ala Pro Pro Cys Pro  Pro Ser Gln Leu Gly  Gln Pro Gly 

    3365                 3370                 3375             





Gln Pro  Pro Ser Ser Lys Met  Pro Gln Val Ser Gln  Glu Ala Lys 

    3380                 3385                 3390             





Gly Thr  Gln Thr Gly Val Glu  Gln Pro Arg Leu Pro  Ala Gly Pro 

    3395                 3400                 3405             





Ala Asn  Arg Pro Pro Glu Pro  His Thr Gln Val Gln  Arg Ala Gln 

    3410                 3415                 3420             





Ala Glu  Thr Gly Pro Thr Ser  Phe Pro Ser Pro Val  Ser Val Ser 

    3425                 3430                 3435             





Met Lys  Pro Asp Leu Pro Val  Ser Leu Pro Thr Gln  Thr Ala Pro 

    3440                 3445                 3450             





Lys Gln  Pro Leu Phe Val Pro  Thr Thr Ser Gly Pro  Ser Thr Pro 

    3455                 3460                 3465             





Pro Gly  Leu Val Leu Pro His  Thr Glu Phe Gln Pro  Ala Pro Lys 

    3470                 3475                 3480             





Gln Asp  Ser Ser Pro His Leu  Thr Ser Gln Arg Pro  Val Asp Met 

    3485                 3490                 3495             





Val Gln  Leu Leu Lys Lys Tyr  Pro Ile Val Trp Gln  Gly Leu Leu 

    3500                 3505                 3510             





Ala Leu  Lys Asn Asp Thr Ala  Ala Val Gln Leu His  Phe Val Ser 

    3515                 3520                 3525             





Gly Asn  Asn Val Leu Ala His  Arg Ser Leu Pro Leu  Ser Glu Gly 

    3530                 3535                 3540             





Gly Pro  Pro Leu Arg Ile Ala  Gln Arg Met Arg Leu  Glu Ala Thr 

    3545                 3550                 3555             





Gln Leu  Glu Gly Val Ala Arg  Arg Met Thr Val Glu  Thr Asp Tyr 

    3560                 3565                 3570             





Cys Leu  Leu Leu Ala Leu Pro  Cys Gly Arg Asp Gln  Glu Asp Val 

    3575                 3580                 3585             





Val Ser  Gln Thr Glu Ser Leu  Lys Ala Ala Phe Ile  Thr Tyr Leu 

    3590                 3595                 3600             





Gln Ala  Lys Gln Ala Ala Gly  Ile Ile Asn Val Pro  Asn Pro Gly 

    3605                 3610                 3615             





Ser Asn  Gln Pro Ala Tyr Val  Leu Gln Ile Phe Pro  Pro Cys Glu 

    3620                 3625                 3630             





Phe Ser  Glu Ser His Leu Ser  Arg Leu Ala Pro Asp  Leu Leu Ala 

    3635                 3640                 3645             





Ser Ile  Ser Asn Ile Ser Pro  His Leu Met Ile Val  Ile Ala Ser 

    3650                 3655                 3660             





Val 

    





<210>  267

<211>  3893

<212>  DNA

<213>  Homo sapiens



<400>  267

gggcagaggt ctccccgccc cgcccctcgt ctcctccaag atggcgagcg gcggcagcgg       60



gggggtgtca gtacctgcgc tgtggagtga agtgaaccgg tatggccaga acggcgactt      120



cacgcgcgct ctcaagaccg tcaataagat actacagatc aacaaagatg acgtaactgc      180



cctgcattgt aaagtggtat gccttatcca gaatggaagt ttcaaggaag ctttgaatgt      240



catcaatact cacaccaaag tgttagccaa taactctctc tcctttgaaa aggcatattg      300



cgagtacagg ctgaacagaa ttgagaatgc cttgaagaca atagaaagtg ccaaccagca      360



gacagacaaa ctgaaggagc tttatggaca agtgttatac cgtttggaac gctatgatga      420



atgcttagca gtgtatagag atctcgtccg aaactcccaa gatgattatg atgaggagag      480



gaaaacaaac ctttcagcag ttgttgcagc tcaaagcaat tgggaaaaag tggttccaga      540



gaacctgggc ctccaagaag gcacacatga gctgtgctac aacactgcat gtgcactgat      600



aggccaaggc cagctgaacc aggccatgaa aatcctacaa aaagctgaag atctttgccg      660



ccgttcatta tcagaagaca ctgatgggac tgaggaagac ccacaggcag aactggccat      720



cattcatggt cagatggctt atattctgca gcttcagggt cgaacagagg aggctttgca      780



actttacaat caaataataa aactaaaacc aacagatgtg ggattactag ctgtaattgc      840



aaataacatc attaccatta acaaggacca aaatgtcttt gactccaaga agaaagtgaa      900



attaaccaat gcggaaggag tagagtttaa gctttccaag aaacaactac aagctataga      960



atttaacaaa gctttacttg ctatgtacac aaaccaggct gaacaatgcc gcaaaatatc     1020



tgccagttta cagtcccaaa gtcccgagca tctcttacct gtgttaatcc aagctgccca     1080



gctctgccgt gaaaagcagc acacaaaagc aatagagctg cttcaggaat tttcagatca     1140



gcatccagaa aatgcagctg aaattaagct gaccatggca cagttgaaaa tttctcaagg     1200



taatatttct aaagcatgtc taatattgag aagcatagag gagttaaagc ataaaccagg     1260



catggtatct gcattagtta ccatgtatag ccatgaagaa gatattgata gtgccattga     1320



ggtcttcaca caagctatcc agtggtatca aaaccatcag ccaaaatctc ctgctcattt     1380



gtccttgata agagaagctg caaacttcaa actcaaatat gggcggaaga aggaggcaat     1440



tagtgaccta caacagctgt ggaaacaaaa tccaaaagat attcacaccc tggcacagct     1500



tatttctgct tactcacttg tagatccaga gaaagccaaa gctcttagta aacacttgcc     1560



atcgtcagat agtatgtctc taaaagtaga tgttgaggct cttgaaaatt ctgctggtgc     1620



tacatacatt cggaagaagg gtggaaaagt tactggagat agtcaaccaa aggaacaagg     1680



acagggagat ttgaaaaaga agaaaaagaa aaagaaggga aaattgccta agaattatga     1740



cccaaaagtt accccagatc cagaaagatg gctgccaatg cgagaacgtt cttactaccg     1800



gggaagaaag aagggtaaaa agaaggatca gattggaaaa gggacccagg gagcaactgc     1860



aggagcttca tctgaactgg atgccagtaa aactgtgagc agcccaccca cctccccaag     1920



acctggcagt gctgcaacag tatctgcctc tacaagtaac atcatacccc caagacacca     1980



gaaacctgca ggggctccag caacaaaaaa gaaacagcaa cagaaaaaga agaaaggtgg     2040



aaaaggtggc tggtgatgag aatattcttg ttgcaggctg tttttaaact agtgtcagtg     2100



acactaggaa tataataaag gtaacacagc aagaagcaca gaactactcc ctcttcatct     2160



ccatattttc ataatttctt gtgtttcaaa tagggaaaca tcttcctcaa agtctgccta     2220



gtgagatatg gcctactggt tgcctcatag ctttgtacag attatgagga ctgaaaataa     2280



ttgggcattt acccatcttg gtatctgttg tatcctttat ctgtgtgtgc tgatttgatc     2340



ttttttcagt ttcacatacc ttatctaagg tttcccagga tttaaacaga aactacttct     2400



atgatttcag ctggagtctg aagatacttg tttctgttca agtcccactt taaattatgt     2460



cttaggagac tgaaagtgga atcttctgag cattcctaaa tatctgctta gaaatatcat     2520



gtgataaaga gggaccttct taatacactg atgttcttca ctaaatggat ggccacaaga     2580



aaaataaagt aaatgtctta aataatttaa ccataaattt tctgtcatgt gatactggaa     2640



tatgggatac ttttcatgtt tatatatata tatatatgta tatatatata catatatata     2700



tatatataaa catgaaatat atatatatgg ctcctttgtg ccccatgtca ttttcagatt     2760



atggtagcat gctgatacag caccatgaaa gaactcaagg aaaatatatc aatgtaagaa     2820



gttcactctt agacccagtg ttctgaggtc acatgggttt ggactgtctc aatcagaaag     2880



attaatgact gttatcaaga acatgaacat tggcttcctc catagagaag aaatcagtat     2940



ctgagttgca taccaggcag tattaaaatc taacaggtct gtttggccca ttgatagata     3000



ctcaaatggt gtctccttct ggttatggat tttgaccatt gattaccttt ctcaatgtaa     3060



tgaagtattt tacagtcaat ttgtggtgta aatgttgctc ttgtctttcc ttgcttacaa     3120



actactttca cattgaacag ctgtgagaca gacatattga gatgcctgcc cttgttagta     3180



ttcattttat gctgcccaag atatcattta atttagactt aacaagtatt tccttgtgat     3240



tatattactc tgtccttgtt aataaagtgc tgctgtgttt gactctgaac atactaccaa     3300



aacttcttca aagagttttt tatgaaagac tttcctcctt tacaagaaag aaatggggtg     3360



ctgcctttct gtttagtaaa agcagaattt gcagtggcat ctaaagagat cttttttaaa     3420



taaaaattat gtattgtggc ataatccttt ttttgagctc tacagagaac agtcttttgg     3480



taatagtggc aggtatttat tccttctgaa tatatacccc attataggaa taactgttac     3540



ttatttagga ttccatcatt gaaaattttg acccaaggca cagcagtgaa atttatagtt     3600



ctcaatttag ttgtcattat tgacaggcat tggtattatt agtcattgct aagcaactaa     3660



aacttcatca gttcaaataa gttttaattg tcaaatgaag tataaacaca tgaactttct     3720



agaaatattt cctcttttgg ataggtcttt aaccagttca tatatatact ttgtcaaata     3780



tatggatgtg tatgtgtaca tttataagaa ccagtatgga tacatccatt cactgtggta     3840



cattttaaaa taaaatattt tagcagtgaa tatggaaaaa aaaaaaaaaa aaa            3893





<210>  268

<211>  671

<212>  PRT

<213>  Homo sapiens



<400>  268



Met Ala Ser Gly Gly Ser Gly Gly Val Ser Val Pro Ala Leu Trp Ser 

1               5                   10                  15      





Glu Val Asn Arg Tyr Gly Gln Asn Gly Asp Phe Thr Arg Ala Leu Lys 

            20                  25                  30          





Thr Val Asn Lys Ile Leu Gln Ile Asn Lys Asp Asp Val Thr Ala Leu 

        35                  40                  45              





His Cys Lys Val Val Cys Leu Ile Gln Asn Gly Ser Phe Lys Glu Ala 

    50                  55                  60                  





Leu Asn Val Ile Asn Thr His Thr Lys Val Leu Ala Asn Asn Ser Leu 

65                  70                  75                  80  





Ser Phe Glu Lys Ala Tyr Cys Glu Tyr Arg Leu Asn Arg Ile Glu Asn 

                85                  90                  95      





Ala Leu Lys Thr Ile Glu Ser Ala Asn Gln Gln Thr Asp Lys Leu Lys 

            100                 105                 110         





Glu Leu Tyr Gly Gln Val Leu Tyr Arg Leu Glu Arg Tyr Asp Glu Cys 

        115                 120                 125             





Leu Ala Val Tyr Arg Asp Leu Val Arg Asn Ser Gln Asp Asp Tyr Asp 

    130                 135                 140                 





Glu Glu Arg Lys Thr Asn Leu Ser Ala Val Val Ala Ala Gln Ser Asn 

145                 150                 155                 160 





Trp Glu Lys Val Val Pro Glu Asn Leu Gly Leu Gln Glu Gly Thr His 

                165                 170                 175     





Glu Leu Cys Tyr Asn Thr Ala Cys Ala Leu Ile Gly Gln Gly Gln Leu 

            180                 185                 190         





Asn Gln Ala Met Lys Ile Leu Gln Lys Ala Glu Asp Leu Cys Arg Arg 

        195                 200                 205             





Ser Leu Ser Glu Asp Thr Asp Gly Thr Glu Glu Asp Pro Gln Ala Glu 

    210                 215                 220                 





Leu Ala Ile Ile His Gly Gln Met Ala Tyr Ile Leu Gln Leu Gln Gly 

225                 230                 235                 240 





Arg Thr Glu Glu Ala Leu Gln Leu Tyr Asn Gln Ile Ile Lys Leu Lys 

                245                 250                 255     





Pro Thr Asp Val Gly Leu Leu Ala Val Ile Ala Asn Asn Ile Ile Thr 

            260                 265                 270         





Ile Asn Lys Asp Gln Asn Val Phe Asp Ser Lys Lys Lys Val Lys Leu 

        275                 280                 285             





Thr Asn Ala Glu Gly Val Glu Phe Lys Leu Ser Lys Lys Gln Leu Gln 

    290                 295                 300                 





Ala Ile Glu Phe Asn Lys Ala Leu Leu Ala Met Tyr Thr Asn Gln Ala 

305                 310                 315                 320 





Glu Gln Cys Arg Lys Ile Ser Ala Ser Leu Gln Ser Gln Ser Pro Glu 

                325                 330                 335     





His Leu Leu Pro Val Leu Ile Gln Ala Ala Gln Leu Cys Arg Glu Lys 

            340                 345                 350         





Gln His Thr Lys Ala Ile Glu Leu Leu Gln Glu Phe Ser Asp Gln His 

        355                 360                 365             





Pro Glu Asn Ala Ala Glu Ile Lys Leu Thr Met Ala Gln Leu Lys Ile 

    370                 375                 380                 





Ser Gln Gly Asn Ile Ser Lys Ala Cys Leu Ile Leu Arg Ser Ile Glu 

385                 390                 395                 400 





Glu Leu Lys His Lys Pro Gly Met Val Ser Ala Leu Val Thr Met Tyr 

                405                 410                 415     





Ser His Glu Glu Asp Ile Asp Ser Ala Ile Glu Val Phe Thr Gln Ala 

            420                 425                 430         





Ile Gln Trp Tyr Gln Asn His Gln Pro Lys Ser Pro Ala His Leu Ser 

        435                 440                 445             





Leu Ile Arg Glu Ala Ala Asn Phe Lys Leu Lys Tyr Gly Arg Lys Lys 

    450                 455                 460                 





Glu Ala Ile Ser Asp Leu Gln Gln Leu Trp Lys Gln Asn Pro Lys Asp 

465                 470                 475                 480 





Ile His Thr Leu Ala Gln Leu Ile Ser Ala Tyr Ser Leu Val Asp Pro 

                485                 490                 495     





Glu Lys Ala Lys Ala Leu Ser Lys His Leu Pro Ser Ser Asp Ser Met 

            500                 505                 510         





Ser Leu Lys Val Asp Val Glu Ala Leu Glu Asn Ser Ala Gly Ala Thr 

        515                 520                 525             





Tyr Ile Arg Lys Lys Gly Gly Lys Val Thr Gly Asp Ser Gln Pro Lys 

    530                 535                 540                 





Glu Gln Gly Gln Gly Asp Leu Lys Lys Lys Lys Lys Lys Lys Lys Gly 

545                 550                 555                 560 





Lys Leu Pro Lys Asn Tyr Asp Pro Lys Val Thr Pro Asp Pro Glu Arg 

                565                 570                 575     





Trp Leu Pro Met Arg Glu Arg Ser Tyr Tyr Arg Gly Arg Lys Lys Gly 

            580                 585                 590         





Lys Lys Lys Asp Gln Ile Gly Lys Gly Thr Gln Gly Ala Thr Ala Gly 

        595                 600                 605             





Ala Ser Ser Glu Leu Asp Ala Ser Lys Thr Val Ser Ser Pro Pro Thr 

    610                 615                 620                 





Ser Pro Arg Pro Gly Ser Ala Ala Thr Val Ser Ala Ser Thr Ser Asn 

625                 630                 635                 640 





Ile Ile Pro Pro Arg His Gln Lys Pro Ala Gly Ala Pro Ala Thr Lys 

                645                 650                 655     





Lys Lys Gln Gln Gln Lys Lys Lys Lys Gly Gly Lys Gly Gly Trp 

            660                 665                 670     





<210>  269

<211>  3394

<212>  DNA

<213>  Homo sapiens



<400>  269

ccgcgcgtgt ggcagtcgcg gaaggcgcgg gagcttgcgt gctgctgggc ctgagctgtc       60



tgtctcgttt ctgtccgcgc gccctgcatc ccggccccgg gcgcccgctg gaggtcgccg      120



aggagccaca gggctgactg gtctgctgcc cgggcccagg agtgcctggt gtagcagtcg      180



cggagccatc ccggcgtctg ctgccatgac cgactctccc ctcagaggag actcttcctc      240



agcggtggct gcagagacag atgagcggcg gctcctggcc gcgggaccgt gagacgggtt      300



cgtggccggc catttagggg gacgctgcga ccaccgcctg cgcccctccg gactggttcc      360



ttgggccccg gaagctcgcg gcgggccctg cgggaggcgg catgctcccg cggaggctgc      420



tggccgcctg gctggcgggg acgcggggcg ggggcctgct ggcgcttctg gccaatcagt      480



gccgcttcgt cacgggcctg cgcgtgcggc gcgcgcagca gatcgcgcag ctctacggcc      540



gcctctactc cgagagctca cgccgcgttc tcctcggccg cctctggcgc cggctgcacg      600



gccgtcctgg ccatgcctct gccttgatgg cggcgttagc cggcgtcttc gtttgggacg      660



aggagaggat ccaggaggag gagttgcaga gatctattaa tgagatgaag cggttggaag      720



aaatgtcaaa tatgtttcag agctctggag tccagcacca ccctccagaa ccaaaagccc      780



aaacagaagg gaatgaagat tcagagggca aagagcaacg ttgggaaatg gtgatggata      840



agaaacactt taagctgtgg cggcgcccaa ttacaggcac ccacctttac cagtaccgag      900



tttttggaac ctacacagat gtgacacctc ggcagttctt caatgttcag ctggacacag      960



agtatagaaa aaaatgggat gccctggtaa tcaagctgga ggtgattgag agggatgtgg     1020



ttagtggttc cgaggttctt cactgggtaa cccattttcc ttatccaatg tactcacggg     1080



attatgttta tgttcggcgg tatagtgtgg atcaggaaaa caacatgatg gtgttggtgt     1140



cgcgtgctgt ggagcatccg agtgtgccag agtctccaga attcgtcagg gtcagatcat     1200



atgaatccca aatggttatc cgtccccaca agtcatttga tgagaatggc tttgactact     1260



tactaacata cagtgacaat ccccaaacgg tgtttcctcg ctactgtgtt agttggatgg     1320



tttccagtgg catgccagat ttcctggaga agctgcacat ggccactctg aaagccaaga     1380



atatggagat taaagtaaag gactacatct cagctaagcc tctggaaatg agtagtgaag     1440



ccaaggccac cagccagtcc tctgagcgaa agaacgaggg cagctgtggc cctgctcgga     1500



ttgagtatgc ttgacaggct ttgggataag aagggacaag gtgcttctag ccctgtctca     1560



gtccgttatc actctgctgt agaaggggga catgccacat gtattagaag gcatctgctg     1620



taacttccag tgcaagataa ttcaataact gatgtcccat ttcattcaga gcccttattg     1680



ctcttatcaa aacagaagaa ggctacattt gtgggagtgt tgtcatattc tcaggccaac     1740



tgttttgaaa ttcggtatct cactgagcta atctggaaca aacctctcac ctcaggccag     1800



aaggggatga cctccatttg cttctctgag tagtttcctc tgctgacatt ccaaatccca     1860



ccatcgattg tgcagcgctt tggatttcct tcagttctcc aggtccacct ggaaagtata     1920



gttggccagt tgagtctctc aaatgagggg ctactgggag tgctcttggt aacaatcatg     1980



atgtgaatgg gtgtgaacga tacttggcta tgttaagtgc cttgtccgca ccttgctttt     2040



atctctagag acatgaagtt attattaatt tttttttttt ttaagtagag atggagtttc     2100



actctgtttc ccaggctggt cttgaactcc tgggccatgc ctggccaggg acatgaattt     2160



gtacaaagaa atttccctcc ctgcctgcac aatatcaccc attgactcac cttatccaaa     2220



gcaagtttcc tgtgaatcgg ccagttcttc tatattcatt ggatcattgc ctccttccta     2280



accttcccca tttaccaaga acactgggag actaatcctt ttagatagta gctttttgat     2340



gctcaaaaca tcacatttaa atttagttta aaaatttttt aacttttgtg tcaaatagga     2400



gttgaggaat tgagcaggat tctaccctag tccgattgta tagaaaacac cattttgatt     2460



caggtattat ttttcatatt tcaggtttga cttgttcttt tcagaaggct aaagtcagag     2520



gaatgggggc tgggccactc ccttggagct ctcagatcta cagacaagct gtgtgaatgc     2580



atagatgtaa tcttgtctca aatactaata cagtggagat ttggtttatg ttaccattaa     2640



gttcctctaa aaagtttttc ttcctctctt cagagccaaa ataaaagtga actacactgt     2700



tcagataagg tcacaatctg atgctgtcag tttgaccgag ctggttttgc ttatggtcat     2760



gctgcaattt gttagaataa tagggatcaa gttttaaatc ctcctccttc ccttttttct     2820



ggagtcttga gggccagagt ttttgttttt gtttttgttt ttgttttcct gcttgctact     2880



gttttgtggt gttgaaaagt ggtttaaacc tgagactaac ttaaacactt ccttgacctt     2940



cttgttgcct gttcattttt gtgccaagga agtagctgcc ccagtgtatg tcttgccttc     3000



tccgcgtcat tgttggaaga ggagagatgc atcgagcagt cccagctgct tttcatttat     3060



tacttcttct ttccaggacc tgacagaagt cagggaagag tccctgggtt atgtccaaac     3120



ttagcacctg caattgttgg gatgtggatg gatgtgtgca taagagagag agagaatatg     3180



tgtgtgtgtg tgtgcgtctg cgagcgcaca cacatgcaca agtgcgaagg agttgcggtt     3240



gctccatgtt ctgacttagg gcaatttgat tctgcacttg gggtctgtct gtacagttac     3300



tcatgtcatt gtaatgattt cactcctaac tgtgacattt ttatcaaatg tgtgaataaa     3360



tacataaaga ttggtacaaa aaaaaaaaaa aaaa                                 3394





<210>  270

<211>  370

<212>  PRT

<213>  Homo sapiens



<400>  270



Met Leu Pro Arg Arg Leu Leu Ala Ala Trp Leu Ala Gly Thr Arg Gly 

1               5                   10                  15      





Gly Gly Leu Leu Ala Leu Leu Ala Asn Gln Cys Arg Phe Val Thr Gly 

            20                  25                  30          





Leu Arg Val Arg Arg Ala Gln Gln Ile Ala Gln Leu Tyr Gly Arg Leu 

        35                  40                  45              





Tyr Ser Glu Ser Ser Arg Arg Val Leu Leu Gly Arg Leu Trp Arg Arg 

    50                  55                  60                  





Leu His Gly Arg Pro Gly His Ala Ser Ala Leu Met Ala Ala Leu Ala 

65                  70                  75                  80  





Gly Val Phe Val Trp Asp Glu Glu Arg Ile Gln Glu Glu Glu Leu Gln 

                85                  90                  95      





Arg Ser Ile Asn Glu Met Lys Arg Leu Glu Glu Met Ser Asn Met Phe 

            100                 105                 110         





Gln Ser Ser Gly Val Gln His His Pro Pro Glu Pro Lys Ala Gln Thr 

        115                 120                 125             





Glu Gly Asn Glu Asp Ser Glu Gly Lys Glu Gln Arg Trp Glu Met Val 

    130                 135                 140                 





Met Asp Lys Lys His Phe Lys Leu Trp Arg Arg Pro Ile Thr Gly Thr 

145                 150                 155                 160 





His Leu Tyr Gln Tyr Arg Val Phe Gly Thr Tyr Thr Asp Val Thr Pro 

                165                 170                 175     





Arg Gln Phe Phe Asn Val Gln Leu Asp Thr Glu Tyr Arg Lys Lys Trp 

            180                 185                 190         





Asp Ala Leu Val Ile Lys Leu Glu Val Ile Glu Arg Asp Val Val Ser 

        195                 200                 205             





Gly Ser Glu Val Leu His Trp Val Thr His Phe Pro Tyr Pro Met Tyr 

    210                 215                 220                 





Ser Arg Asp Tyr Val Tyr Val Arg Arg Tyr Ser Val Asp Gln Glu Asn 

225                 230                 235                 240 





Asn Met Met Val Leu Val Ser Arg Ala Val Glu His Pro Ser Val Pro 

                245                 250                 255     





Glu Ser Pro Glu Phe Val Arg Val Arg Ser Tyr Glu Ser Gln Met Val 

            260                 265                 270         





Ile Arg Pro His Lys Ser Phe Asp Glu Asn Gly Phe Asp Tyr Leu Leu 

        275                 280                 285             





Thr Tyr Ser Asp Asn Pro Gln Thr Val Phe Pro Arg Tyr Cys Val Ser 

    290                 295                 300                 





Trp Met Val Ser Ser Gly Met Pro Asp Phe Leu Glu Lys Leu His Met 

305                 310                 315                 320 





Ala Thr Leu Lys Ala Lys Asn Met Glu Ile Lys Val Lys Asp Tyr Ile 

                325                 330                 335     





Ser Ala Lys Pro Leu Glu Met Ser Ser Glu Ala Lys Ala Thr Ser Gln 

            340                 345                 350         





Ser Ser Glu Arg Lys Asn Glu Gly Ser Cys Gly Pro Ala Arg Ile Glu 

        355                 360                 365             





Tyr Ala 

    370 





<210>  271

<211>  2490

<212>  DNA

<213>  Homo sapiens



<400>  271

actgtccgcc gccgtgtccg cggctgcgcc agacagtgta gaacctgcgg cctcgatgtc       60



cttctcccgt gccctattgt gggctcggct cccggcgggg cgccaggctg gccaccgggc      120



agccatctgc tctgcccttc gtccccactt tgggcccttt cccggggttc tggggcaagt      180



ttctgtcctt gccaccgcct cctcctctgc ctccggtggc tccaaaatac caaacacgtc      240



cttgttcgtg cccctgactg tgaaacctca gggccccagc gccgacggcg acgtcggggc      300



cgagctaacc cggcctctgg acaagaatga agtaaagaag gtcttagaca aattttacaa      360



gaggaaagaa attcagaaac tgggtgctga ttatggactt gatgctcgtc tcttccacca      420



agctttcata agctttagaa attatattat gcagtctcat tccctggatg tggacattca      480



cattgttttg aatgatattt gcttcggtgc agctcatgcg gatgatttat tcccattttt      540



cttgagacat gccaaacaaa tatttcctgt gttggactgt aaggatgatc tacgtaaaat      600



cagtgactta agaataccac ctaactggta cccagatgct agagccatgc agcggaagat      660



aatatttcat tcaggcccca caaacagtgg aaagacttat cacgcaatcc agaaatactt      720



ctcagcaaag tctggagtgt attgtggccc tctaaaatta ctggcacatg agatcttcga      780



aaagagtaat gctgctggtg tgccatgtga cttggtgaca ggtgaagagc gtgtgacagt      840



tcagccaaat gggaaacagg cttcacatgt ttcttgtaca gttgagatgt gcagtgttac      900



aactccttat gaagtggctg taattgatga aattcaaatg attagagatc cagccagagg      960



atgggcctgg accagagcac ttctaggact gtgtgctgaa gaggttcatt tgtgtggaga     1020



acctgctgct attgacctgg tgatggagct tatgtacaca acgggggagg aagtggaggt     1080



tcgagactat aagaggctta cccccatttc tgtgctggac catgcactag aatctttaga     1140



taaccttcgg cctggggact gcattgtctg ttttagcaag aatgatattt attctgtgag     1200



tcggcagatt gaaattcggg gattagaatc agctgttata tatggcagtc tcccacctgg     1260



gaccaaactt gctcaagcaa aaaagtttaa tgatcccaat gacccatgca aaatcttggt     1320



tgctacagat gcaattggca tgggacttaa tttgagcata aggagaatta ttttttactc     1380



ccttataaag cccagtatca atgaaaaggg agagagagaa ctagaaccaa tcacaacctc     1440



tcaagccctg cagattgctg gcagagctgg cagattcagc tcacggttta aagaaggaga     1500



ggttacaaca atgaatcatg aagatctcag tttattaaag gaaattttga agaggcctgt     1560



ggatcctata agggcagctg gtcttcatcc aactgctgag cagattgaaa tgtttgccta     1620



ccatctccct gatgcaacac tgtccaatct cattgatatt tttgtagact tttcacaagt     1680



tgatgggcag tattttgtct gcaatatgga tgattttaaa ttttctgcag agttgatcca     1740



gcatattcca ctaagtctgc gagtgaggta tgttttctgc acagctccta tcaacaagaa     1800



gcagcctttt gtgtgttctt cactgttaca gtttgccagg cagtatagca ggaatgagcc     1860



cctgaccttt gcatggttac gccgatacat caaatggcct ttacttccac ctaagaatat     1920



taaagacctc atggatcttg aagctgtcca cgatgtcttg gatctttact tgtggctaag     1980



ctaccgattt atggatatgt ttccagatgc cagccttatt cgagatctcc agaaagaact     2040



agatggtatt atccaagatg gtgtgcacaa tatcactaaa ttgattaaaa tgtctgagac     2100



gcataagctg ttgaatttgg agggctttcc atcagggagc cagtcacgat tgtcaggaac     2160



cttaaagagc caagctagaa ggacacgcgg caccaaagct ctagggagta aagctactga     2220



gccacccagc cccgatgcag gagagctgtc ccttgcttcc agattggtgc agcaaggact     2280



cctcactcca gacatgctga aacagctaga aaaagagtgg atgacacaac aaactgaaca     2340



caacaaagaa aaaacagagt ctgggactca tccaaaaggg acgagaagaa agaagaagga     2400



acctgattcg gactagtttt ctgttcctgt tttttttttt ttatttaatt ttgcaaataa     2460



aaatttattt tgaagaaaaa aaaaaaaaaa                                      2490





<210>  272

<211>  786

<212>  PRT

<213>  Homo sapiens



<400>  272



Met Ser Phe Ser Arg Ala Leu Leu Trp Ala Arg Leu Pro Ala Gly Arg 

1               5                   10                  15      





Gln Ala Gly His Arg Ala Ala Ile Cys Ser Ala Leu Arg Pro His Phe 

            20                  25                  30          





Gly Pro Phe Pro Gly Val Leu Gly Gln Val Ser Val Leu Ala Thr Ala 

        35                  40                  45              





Ser Ser Ser Ala Ser Gly Gly Ser Lys Ile Pro Asn Thr Ser Leu Phe 

    50                  55                  60                  





Val Pro Leu Thr Val Lys Pro Gln Gly Pro Ser Ala Asp Gly Asp Val 

65                  70                  75                  80  





Gly Ala Glu Leu Thr Arg Pro Leu Asp Lys Asn Glu Val Lys Lys Val 

                85                  90                  95      





Leu Asp Lys Phe Tyr Lys Arg Lys Glu Ile Gln Lys Leu Gly Ala Asp 

            100                 105                 110         





Tyr Gly Leu Asp Ala Arg Leu Phe His Gln Ala Phe Ile Ser Phe Arg 

        115                 120                 125             





Asn Tyr Ile Met Gln Ser His Ser Leu Asp Val Asp Ile His Ile Val 

    130                 135                 140                 





Leu Asn Asp Ile Cys Phe Gly Ala Ala His Ala Asp Asp Leu Phe Pro 

145                 150                 155                 160 





Phe Phe Leu Arg His Ala Lys Gln Ile Phe Pro Val Leu Asp Cys Lys 

                165                 170                 175     





Asp Asp Leu Arg Lys Ile Ser Asp Leu Arg Ile Pro Pro Asn Trp Tyr 

            180                 185                 190         





Pro Asp Ala Arg Ala Met Gln Arg Lys Ile Ile Phe His Ser Gly Pro 

        195                 200                 205             





Thr Asn Ser Gly Lys Thr Tyr His Ala Ile Gln Lys Tyr Phe Ser Ala 

    210                 215                 220                 





Lys Ser Gly Val Tyr Cys Gly Pro Leu Lys Leu Leu Ala His Glu Ile 

225                 230                 235                 240 





Phe Glu Lys Ser Asn Ala Ala Gly Val Pro Cys Asp Leu Val Thr Gly 

                245                 250                 255     





Glu Glu Arg Val Thr Val Gln Pro Asn Gly Lys Gln Ala Ser His Val 

            260                 265                 270         





Ser Cys Thr Val Glu Met Cys Ser Val Thr Thr Pro Tyr Glu Val Ala 

        275                 280                 285             





Val Ile Asp Glu Ile Gln Met Ile Arg Asp Pro Ala Arg Gly Trp Ala 

    290                 295                 300                 





Trp Thr Arg Ala Leu Leu Gly Leu Cys Ala Glu Glu Val His Leu Cys 

305                 310                 315                 320 





Gly Glu Pro Ala Ala Ile Asp Leu Val Met Glu Leu Met Tyr Thr Thr 

                325                 330                 335     





Gly Glu Glu Val Glu Val Arg Asp Tyr Lys Arg Leu Thr Pro Ile Ser 

            340                 345                 350         





Val Leu Asp His Ala Leu Glu Ser Leu Asp Asn Leu Arg Pro Gly Asp 

        355                 360                 365             





Cys Ile Val Cys Phe Ser Lys Asn Asp Ile Tyr Ser Val Ser Arg Gln 

    370                 375                 380                 





Ile Glu Ile Arg Gly Leu Glu Ser Ala Val Ile Tyr Gly Ser Leu Pro 

385                 390                 395                 400 





Pro Gly Thr Lys Leu Ala Gln Ala Lys Lys Phe Asn Asp Pro Asn Asp 

                405                 410                 415     





Pro Cys Lys Ile Leu Val Ala Thr Asp Ala Ile Gly Met Gly Leu Asn 

            420                 425                 430         





Leu Ser Ile Arg Arg Ile Ile Phe Tyr Ser Leu Ile Lys Pro Ser Ile 

        435                 440                 445             





Asn Glu Lys Gly Glu Arg Glu Leu Glu Pro Ile Thr Thr Ser Gln Ala 

    450                 455                 460                 





Leu Gln Ile Ala Gly Arg Ala Gly Arg Phe Ser Ser Arg Phe Lys Glu 

465                 470                 475                 480 





Gly Glu Val Thr Thr Met Asn His Glu Asp Leu Ser Leu Leu Lys Glu 

                485                 490                 495     





Ile Leu Lys Arg Pro Val Asp Pro Ile Arg Ala Ala Gly Leu His Pro 

            500                 505                 510         





Thr Ala Glu Gln Ile Glu Met Phe Ala Tyr His Leu Pro Asp Ala Thr 

        515                 520                 525             





Leu Ser Asn Leu Ile Asp Ile Phe Val Asp Phe Ser Gln Val Asp Gly 

    530                 535                 540                 





Gln Tyr Phe Val Cys Asn Met Asp Asp Phe Lys Phe Ser Ala Glu Leu 

545                 550                 555                 560 





Ile Gln His Ile Pro Leu Ser Leu Arg Val Arg Tyr Val Phe Cys Thr 

                565                 570                 575     





Ala Pro Ile Asn Lys Lys Gln Pro Phe Val Cys Ser Ser Leu Leu Gln 

            580                 585                 590         





Phe Ala Arg Gln Tyr Ser Arg Asn Glu Pro Leu Thr Phe Ala Trp Leu 

        595                 600                 605             





Arg Arg Tyr Ile Lys Trp Pro Leu Leu Pro Pro Lys Asn Ile Lys Asp 

    610                 615                 620                 





Leu Met Asp Leu Glu Ala Val His Asp Val Leu Asp Leu Tyr Leu Trp 

625                 630                 635                 640 





Leu Ser Tyr Arg Phe Met Asp Met Phe Pro Asp Ala Ser Leu Ile Arg 

                645                 650                 655     





Asp Leu Gln Lys Glu Leu Asp Gly Ile Ile Gln Asp Gly Val His Asn 

            660                 665                 670         





Ile Thr Lys Leu Ile Lys Met Ser Glu Thr His Lys Leu Leu Asn Leu 

        675                 680                 685             





Glu Gly Phe Pro Ser Gly Ser Gln Ser Arg Leu Ser Gly Thr Leu Lys 

    690                 695                 700                 





Ser Gln Ala Arg Arg Thr Arg Gly Thr Lys Ala Leu Gly Ser Lys Ala 

705                 710                 715                 720 





Thr Glu Pro Pro Ser Pro Asp Ala Gly Glu Leu Ser Leu Ala Ser Arg 

                725                 730                 735     





Leu Val Gln Gln Gly Leu Leu Thr Pro Asp Met Leu Lys Gln Leu Glu 

            740                 745                 750         





Lys Glu Trp Met Thr Gln Gln Thr Glu His Asn Lys Glu Lys Thr Glu 

        755                 760                 765             





Ser Gly Thr His Pro Lys Gly Thr Arg Arg Lys Lys Lys Glu Pro Asp 

    770                 775                 780                 





Ser Asp 

785     





<210>  273

<211>  4611

<212>  DNA

<213>  Homo sapiens



<400>  273

ctgataaaga gctgggctga gtcatctgtg gaggagaaaa gtcacatcca gctccttcat       60



gttgctgccg atgtgggatt ttcctggctt cgtcagccaa gcaattggct gcctttgccg      120



gaggctttga gaaccaaggc ttgaaggccg gcaggagcat ccagggggaa gcttggcttc      180



agggaggacc tagcagacgt tgggccggag cactagcctc acggagaagg atctgaaaga      240



agccaaggcg cggagccagc agattgcagc ccagctgacc acccctccca gctccaattc      300



ccgtggcgtc cagctcttca acaggcgccg gcagagggtg aacgagttca ccttggagag      360



ccacggccag aggggacaga agcccagcca ggagtccctc agagtgctcc cttcaagcct      420



cccaggccat gcaccggggc tcagcctgag ttccacctcg ctgccggagc caggccctcc      480



acggcacccc agtccccaga gccccgacag aggggtccct ggccacagca tggaggggta      540



ctcagaggag gctagcttgc tgcggcacct ggagaaggtg gccagtgagg aggaagaggt      600



accactggtg gtttatctaa aggagaatgc agcactgctg acagccaatg ggctgcacct      660



gtcccaaaac cgagaggccc agcagtcctc accggcccca cctccagctg aggtccacag      720



cccagctgca gatgtcaacc aaaaccttgc ctcgcccagt gccacgctca ccacaccaac      780



ttctaacagc agccacaatc cgccagccac cgatgtcaat cagaacccac cggcaactgt      840



tgtcccacag agcctgccac tttctagcat ccaacagaat tcctcagagg cccaactccc      900



atctaatggc acagggcctg cttccaaacc cagcaccctg tgtgctgatg ggcaacccca      960



ggcaccggct gaggaggtga gatgcagcac actcctaatt gacaaggtat caactccagc     1020



taccaccacc agcaccttct ccagagaagc tacgctcatc cccagctcca ggcccccagc     1080



ctcagatttc atgtccagct ccctgctcat tgacatccag cccaacaccc tagtggtgtc     1140



agcagatcaa gagatgtctg ggcgagcagc tgccaccacg cccaccaagg tctacagtga     1200



ggtccacttc acactggcca agcccccatc agtggtcaac aggacggcca ggccttttgg     1260



gatccaggcg ccagggggca ccagccagat ggagaggagc cccatgctag agagacgaca     1320



ttttggggag aaggccccgg ctccccagcc ccccagtttg ccagacagga gcccccggcc     1380



acagagacac ataatgtccc gcagccccat ggtggaaagg aggatgatgg ggcagcgaag     1440



cccggcctca gagagacgcc ccttggggaa cttcactgca ccccccacct acactgagac     1500



cttgtccaca gcccctctgg cttcctgggt gaggtctcct ccctcatatt ctgtcctgta     1560



tcccagctcc gaccccaagt cttctcatct gaagggccag gcggttcctg ccagcaagac     1620



gggcattctg gaggagtcga tggcccgccg gggcagccgc aaatccatgt ttactttcgt     1680



ggagaagccc aaggtgaccc cgaatccaga cttgctggat ctggtacaga cagcggatga     1740



gaagcggcgg cagagggacc agggggaggt aggcgtggag gaggagccct tcgcactggg     1800



ggccgaggcc tccaacttcc agcaggagcc agcacctcgt gacagggcca gccccgcggc     1860



ggcggaggag gtggtaccag agtgggcctc ctgcctcaag tcaccccgca tccaggccaa     1920



gccgaagccc aaacccaacc agaacctctc cgaggcctct gggaagggag ctgagctcta     1980



cgcccgccgc cagtcacgga tggagaaata tgtcatcgag tcttcaagcc acacgccaga     2040



gctggcccgc tgcccatcac ctaccatgtc cctgccttcc tcctggaaat accccactaa     2100



cgcccccggg gccttccgag tggcatcccg aagcccagcc cggaccccgc ctgcctccct     2160



ctaccatggc tacctgcctg agaacggggt cctgcgccca gagcccacca agcagccgcc     2220



ataccagctg cgcccctcgc tctttgtcct ctcacctatc aaggagcctg ccaaggtctc     2280



accaagagct gcctcgcccg ccaagcccag ctccttggac ctggtgccca acctgcccaa     2340



gggggctctc cctccatctc ctgccctgcc tcggccctcg cgctcctcac cgggcctcta     2400



cacctccccc ggccaggaca gcctgcagcc cactgccgtg agccctcctt acggcggtga     2460



catctccccc gtgtctccct ccagggcgtg gtctccccga gccaagcagg cccccaggcc     2520



ctccttctct acccggaacg ccgggatcga ggctcaggtg tggaagcctt ccttctgctt     2580



caagtaacga accccacggg ggtcccactg ccggtcaagt tcccctcctt gagggccaga     2640



tggagagcag atgtggcagg aaatggcaca gagctgagtg aggagaatgg ggagtccatg     2700



gttcaaggtc agatgcggcc accagctggc tttgtgacct tgggcgagtc gcctcccctc     2760



tctgagctga agccgcccct cccctactac aacaggggtc ggactccatg tctgagcggg     2820



gaggagggtc atggagagag aactgtctgg cagccctgat gcggtagagg ggcatcctct     2880



ggcctttgtg agctgtaggg atgcagagtc tgatgccagc gtcttgctgg gggagtggcc     2940



tagaagggga tcctaacagg gacttctgga gcagacagag cctgccagtg cctgtggagt     3000



cagccagccg agggtctgcc tcctcagctg ccccaggggg gcctccctcc tgaggctcaa     3060



gctcctggcg tctttcttcc tgttgctgga ttctcacctc catgggcctg tctcttctgc     3120



ctctgccttc tggacaccgt ttcctctccg ctgcttcaga gagctttgcc tcgcctccgc     3180



ctgcgctccc ctccagggtc cttctgctgg ctgcggactc ggcccaccac tgctgtctga     3240



cgcttttctt cctgccccct ctgaggcctg gctctgtttt agggagatca ctgggcccag     3300



gcctcagccc cagttctacc tggcttgctg tcaccgctct aggggtgggg gacgtcccag     3360



gggatcccca ggagaaggag agccctgtag ggggctgtgc agatgtgggt gtgccacagg     3420



gagggtggcc cctagccatg tatccattgg ctgttttggc ttcagattca accaagatct     3480



gcctgactaa aagaagccac ctcagcgcag tggaacgggg cccaggggga ggcaggagag     3540



gagggttccg gtcccatgtc accttctcat ttgctgtgtg actttggccc actcacattc     3600



tctttgggcc tcagttttat catttataca aggagggctt ttctagctgt aacaatctgt     3660



gaggattgag aggataggct ggtgctttga agaaaggcct tgtaagtgac aagacagtcc     3720



cctgggaaga aagagaaagg aaatgggcta ttgccaaagg acaggtggcg ttagatggct     3780



gtgagggtga cctggtgagg gaagggttgg aatgagctgc tgcaggaggc caagggatgc     3840



ctgggctggg ctgggctggg ctggcttagg ctcaggattg cctggggaca gtaggagcat     3900



ggcaggagct ggggcaggtg catagcagtg cagtgggaag ggacagagga gatcttagaa     3960



ttttgaggaa aatctgggac ttgagacctg gattctaaca gaccaactgc atgtgtgtct     4020



gtaggtctca gtttccacat tcatacagtg agggtgttaa gtcaggtagc tggagacttc     4080



ccatcgcctc tgacactttt ggaggtgata tgatacagcc cccgaccaaa ccaggctttg     4140



tggggggtga gagaatacag acacaagtgg caggattcag atggaagctt cgcaaggctg     4200



ggggccgagg accacccact tctctttccc agccctagtt ctgggttccc cagtggggca     4260



aggggtggtg gaggcagtgc ccatgctggg ctgagcctgc agtttttgtg agctctgggc     4320



ttgtctccat gggaacaggg gtgccttctt agtgagctca tttcacacag atcgaggggg     4380



tatgcgtggg ggagttgtga gtgagctcag ctccttcagg cctggcctct cccagaacag     4440



agtgaagccc ctgccctgga cccctgctcc cttctaccct tgagggccac caatggaaga     4500



gcccgccctt cattctgcag ctcctgcggc caggctgagc tctgccccca actttgtttt     4560



ctctcatgtt ctcaatacac tctgcctcaa aaaaaaaaaa aaaaaaaaaa a              4611





<210>  274

<211>  685

<212>  PRT

<213>  Homo sapiens



<400>  274



Met Glu Gly Tyr Ser Glu Glu Ala Ser Leu Leu Arg His Leu Glu Lys 

1               5                   10                  15      





Val Ala Ser Glu Glu Glu Glu Val Pro Leu Val Val Tyr Leu Lys Glu 

            20                  25                  30          





Asn Ala Ala Leu Leu Thr Ala Asn Gly Leu His Leu Ser Gln Asn Arg 

        35                  40                  45              





Glu Ala Gln Gln Ser Ser Pro Ala Pro Pro Pro Ala Glu Val His Ser 

    50                  55                  60                  





Pro Ala Ala Asp Val Asn Gln Asn Leu Ala Ser Pro Ser Ala Thr Leu 

65                  70                  75                  80  





Thr Thr Pro Thr Ser Asn Ser Ser His Asn Pro Pro Ala Thr Asp Val 

                85                  90                  95      





Asn Gln Asn Pro Pro Ala Thr Val Val Pro Gln Ser Leu Pro Leu Ser 

            100                 105                 110         





Ser Ile Gln Gln Asn Ser Ser Glu Ala Gln Leu Pro Ser Asn Gly Thr 

        115                 120                 125             





Gly Pro Ala Ser Lys Pro Ser Thr Leu Cys Ala Asp Gly Gln Pro Gln 

    130                 135                 140                 





Ala Pro Ala Glu Glu Val Arg Cys Ser Thr Leu Leu Ile Asp Lys Val 

145                 150                 155                 160 





Ser Thr Pro Ala Thr Thr Thr Ser Thr Phe Ser Arg Glu Ala Thr Leu 

                165                 170                 175     





Ile Pro Ser Ser Arg Pro Pro Ala Ser Asp Phe Met Ser Ser Ser Leu 

            180                 185                 190         





Leu Ile Asp Ile Gln Pro Asn Thr Leu Val Val Ser Ala Asp Gln Glu 

        195                 200                 205             





Met Ser Gly Arg Ala Ala Ala Thr Thr Pro Thr Lys Val Tyr Ser Glu 

    210                 215                 220                 





Val His Phe Thr Leu Ala Lys Pro Pro Ser Val Val Asn Arg Thr Ala 

225                 230                 235                 240 





Arg Pro Phe Gly Ile Gln Ala Pro Gly Gly Thr Ser Gln Met Glu Arg 

                245                 250                 255     





Ser Pro Met Leu Glu Arg Arg His Phe Gly Glu Lys Ala Pro Ala Pro 

            260                 265                 270         





Gln Pro Pro Ser Leu Pro Asp Arg Ser Pro Arg Pro Gln Arg His Ile 

        275                 280                 285             





Met Ser Arg Ser Pro Met Val Glu Arg Arg Met Met Gly Gln Arg Ser 

    290                 295                 300                 





Pro Ala Ser Glu Arg Arg Pro Leu Gly Asn Phe Thr Ala Pro Pro Thr 

305                 310                 315                 320 





Tyr Thr Glu Thr Leu Ser Thr Ala Pro Leu Ala Ser Trp Val Arg Ser 

                325                 330                 335     





Pro Pro Ser Tyr Ser Val Leu Tyr Pro Ser Ser Asp Pro Lys Ser Ser 

            340                 345                 350         





His Leu Lys Gly Gln Ala Val Pro Ala Ser Lys Thr Gly Ile Leu Glu 

        355                 360                 365             





Glu Ser Met Ala Arg Arg Gly Ser Arg Lys Ser Met Phe Thr Phe Val 

    370                 375                 380                 





Glu Lys Pro Lys Val Thr Pro Asn Pro Asp Leu Leu Asp Leu Val Gln 

385                 390                 395                 400 





Thr Ala Asp Glu Lys Arg Arg Gln Arg Asp Gln Gly Glu Val Gly Val 

                405                 410                 415     





Glu Glu Glu Pro Phe Ala Leu Gly Ala Glu Ala Ser Asn Phe Gln Gln 

            420                 425                 430         





Glu Pro Ala Pro Arg Asp Arg Ala Ser Pro Ala Ala Ala Glu Glu Val 

        435                 440                 445             





Val Pro Glu Trp Ala Ser Cys Leu Lys Ser Pro Arg Ile Gln Ala Lys 

    450                 455                 460                 





Pro Lys Pro Lys Pro Asn Gln Asn Leu Ser Glu Ala Ser Gly Lys Gly 

465                 470                 475                 480 





Ala Glu Leu Tyr Ala Arg Arg Gln Ser Arg Met Glu Lys Tyr Val Ile 

                485                 490                 495     





Glu Ser Ser Ser His Thr Pro Glu Leu Ala Arg Cys Pro Ser Pro Thr 

            500                 505                 510         





Met Ser Leu Pro Ser Ser Trp Lys Tyr Pro Thr Asn Ala Pro Gly Ala 

        515                 520                 525             





Phe Arg Val Ala Ser Arg Ser Pro Ala Arg Thr Pro Pro Ala Ser Leu 

    530                 535                 540                 





Tyr His Gly Tyr Leu Pro Glu Asn Gly Val Leu Arg Pro Glu Pro Thr 

545                 550                 555                 560 





Lys Gln Pro Pro Tyr Gln Leu Arg Pro Ser Leu Phe Val Leu Ser Pro 

                565                 570                 575     





Ile Lys Glu Pro Ala Lys Val Ser Pro Arg Ala Ala Ser Pro Ala Lys 

            580                 585                 590         





Pro Ser Ser Leu Asp Leu Val Pro Asn Leu Pro Lys Gly Ala Leu Pro 

        595                 600                 605             





Pro Ser Pro Ala Leu Pro Arg Pro Ser Arg Ser Ser Pro Gly Leu Tyr 

    610                 615                 620                 





Thr Ser Pro Gly Gln Asp Ser Leu Gln Pro Thr Ala Val Ser Pro Pro 

625                 630                 635                 640 





Tyr Gly Gly Asp Ile Ser Pro Val Ser Pro Ser Arg Ala Trp Ser Pro 

                645                 650                 655     





Arg Ala Lys Gln Ala Pro Arg Pro Ser Phe Ser Thr Arg Asn Ala Gly 

            660                 665                 670         





Ile Glu Ala Gln Val Trp Lys Pro Ser Phe Cys Phe Lys 

        675                 680                 685 





<210>  275

<211>  5384

<212>  DNA

<213>  Homo sapiens



<400>  275

ctgataaaga gctgggctga gtcatctgtg gaggagaaaa gtcacatcca gctccttcat       60



gttgctgccg atgtgggatt ttcctggctt cgtcagccaa gcaattggct gcctttgccg      120



gaggctttga gaaccaaggc ttgaaggccg gcaggagcat ccagggggaa gcttggcttc      180



agggaggacc tagcagacgt tgggccggag cactagcctc acggagaagg atctgaaaga      240



agccaaggcg cggagccagc agattgcagc ccagctgacc acccctccca gctccaattc      300



ccgtggcgtc cagctcttca acaggcgccg gcagagggtg aacgagttca ccttggagag      360



ccacggccag aggggacaga agcccagcca ggagtccctc agagtgctcc cttcaagcct      420



cccaggccat gcaccggggc tcagcctgag ttccacctcg ctgccggagc caggccctcc      480



acggcacccc agtccccaga gccccgacag aggggtccct ggccacagca tggaggggta      540



ctcagaggag gctagcttgc tgcggcacct ggagaaggtg gccagtgagg aggaagaggt      600



accactggtg gtttatctaa aggagaatgc agcactgctg acagccaatg ggctgcacct      660



gtcccaaaac cgagaggccc agcagtcctc accggcccca cctccagctg aggtccacag      720



cccagctgca gatgtcaacc aaaaccttgc ctcgcccagt gccacgctca ccacaccaac      780



ttctaacagc agccacaatc cgccagccac cgatgtcaat cagaacccac cggcaactgt      840



tgtcccacag agcctgccac tttctagcat ccaacagaat tcctcagagg cccaactccc      900



atctaatggc acagggcctg cttccaaacc cagcaccctg tgtgctgatg ggcaacccca      960



ggcaccggct gaggaggtga gatgcagcac actcctaatt gacaaggtat caactccagc     1020



taccaccacc agcaccttct ccagagaagc tacgctcatc cccagctcca ggcccccagc     1080



ctcagatttc atgtccagct ccctgctcat tgacatccag cccaacaccc tagtggtgtc     1140



agcagatcaa gagatgtctg ggcgagcagc tgccaccacg cccaccaagg tctacagtga     1200



ggtccacttc acactggcca agcccccatc agtggtcaac aggacggcca ggccttttgg     1260



gatccaggcg ccagggggca ccagccagat ggagaggagc cccatgctag agagacgaca     1320



ttttggggag aaggccccgg ctccccagcc ccccagtttg ccagacagga gcccccggcc     1380



acagagacac ataatgtccc gcagccccat ggtggaaagg aggatgatgg ggcagcgaag     1440



cccggcctca gagagacgcc ccttggggaa cttcactgca ccccccacct acactgagac     1500



cttgtccaca gcccctctgg cttcctgggt gaggtctcct ccctcatatt ctgtcctgta     1560



tcccagctcc gaccccaagt cttctcatct gaagggccag gcggttcctg ccagcaagac     1620



gggcattctg gaggagtcga tggcccgccg gggcagccgc aaatccatgt ttactttcgt     1680



ggagaagccc aaggtgaccc cgaatccaga cttgctggat ctggtacaga cagcggatga     1740



gaagcggcgg cagagggacc agggggaggt aggcgtggag gaggagccct tcgcactggg     1800



ggccgaggcc tccaacttcc agcaggagcc agcacctcgt gacagggcca gccccgcggc     1860



ggcggaggag gtggtaccag agtgggcctc ctgcctcaag tcaccccgca tccaggccaa     1920



gccgaagccc aaacccaacc agaacctctc cgaggcctct gggaagggag ctgagctcta     1980



cgcccgccgc cagtcacgga tggagaaata tgtcatcgag tcttcaagcc acacgccaga     2040



gctggcccgc tgcccatcac ctaccatgtc cctgccttcc tcctggaaat accccactaa     2100



cgcccccggg gccttccgag tggcatcccg aagcccagcc cggaccccgc ctgcctccct     2160



ctaccatggc tacctgcctg agaacggggt cctgcgccca gagcccacca agcagccgcc     2220



ataccagctg cgcccctcgc tctttgtcct ctcacctatc aaggagcctg ccaaggtctc     2280



accaagagct gcctcgcccg ccaagcccag ctccttggac ctggtgccca acctgcccaa     2340



gggggctctc cctccatctc ctgccctgcc tcggccctcg cgctcctcac cgggcctcta     2400



cacctccccc ggccaggaca gcctgcagcc cactgccgtg agccctcctt acggcggtga     2460



catctccccc gtgtctccct ccagggcgtg gtctccccga gccaagcagg cccccaggcc     2520



ctccttctct acccggaacg ccgggatcga ggctcaggac cgccgggaga gcctgcccac     2580



ctccccaccc tggacgccgg gcgcgtcccg gccccccagc agcctagacg gctgggtgag     2640



cccgggcccg tgggagccag gtcgcgggag cagcatgagc agccccccgc cgctgccgcc     2700



gccaccgccc atgtctccct cgtggagcga gcgctcggtg tccccgctgc gacctgagac     2760



cgaggcgcgg ccccccagcc gccagctgca ggcgcttctg gcgcgaaaca tcatcaatgc     2820



ggcccggcgc aagagcgcct ccccgcggtc ggcgggcgcc gagaacccgc ggcccttctc     2880



cccgccgagg gcgccaccgc ccccgccccc gcccccgccc ccgcccccgc gcatgcgctc     2940



gccacagccc gcccgccccg gctcggctgc tgtgccgggg gcagccttcg cgcccatccc     3000



gcggagcccg ttgcccgccg gtccttcgtc ctgcaccagt ccccggagcc cgctgcccgc     3060



gcctcccagg cccttcctct accgccgctc gcccacggac tccgacgtgt ccctcgactc     3120



cgaggactcc ggggctaagt ctccaggcat cctgggctac aatatctgtc cccgcgggtg     3180



gaatggcagc cttcggctca agcgtggcag cctccccgcc gaggcctcct gcaccaccta     3240



gagccccacc cccgacccca ccccgggagg gcagagccag aagaaggctc attagacctg     3300



ggggacccaa agggtctggc ctctttgggc agccccagag atgaggggtc agcagaggag     3360



agctctgggg ttggggatgg gttagggacg caagcttgag ttctagccct tgctctcatt     3420



cagctgttgt gtgaccctgg gtaagaccct tccttgtttg accctcagct ttcccatctg     3480



tttaatggtg gctttggcca aggcaatcca caaacgtcaa aattcccctt cccatcagta     3540



cacacaccga tgcacacaca ctctctcttt ctctctctct ctctctcaca cacacacaca     3600



cacacacaca cacacacaca cacacacaca ctagttagtg ccttggatga ggcggggcag     3660



tgtgtatatg gacccctgga cttgctacct tcagggttcc atactcgtcc ctcccctcct     3720



ggctctgctg tctggagtct ggcaagcggg gtgtgttcag aaggtcctag gcctgtgtcg     3780



catgtccagg cactggcctg accatccggc tccctggcac caagtcccag gcaggagcag     3840



ctgttttcca tcccttccca gacaagctct atttttatca caatgacctt tagagaggtc     3900



tcccaggcca gctcaaggtg tcccactatc ccctctggag ggaagaggca ggaaaattct     3960



ccccgggtcc ctgtcatgct actttctcca tcccagttca gactgtccag gacatcttat     4020



ctgcagccat aagagaatta taaggcagtg atttccctta ggcccaggac ttgggcctcc     4080



agctcatctg ttccttctgg gcccattcat ggcaggttct gggctcaaag ctgaactggg     4140



gagagaagag atacagagct accatgtgac tttacctgat tgccctcagt ttggggttgc     4200



ttattgggaa agagagagac aaagagttac ttgttacggg aaatatgaaa agcatggcca     4260



ggatgcatag aggagattct agcaggggac aggattggct cagatgaccc ctgagggctc     4320



ttccagtctt gaaatgcatt ccatgatatt aggaagtcgg gggtgggtgg tggtggtggg     4380



ctagttgggc ttgaatttag gggccgatga gcttgggtac gtgagcaggg tgttaagtta     4440



gggtctgcct gtatttctgg tccccttgga aatgtcccct tcttcagtgt cagacctcag     4500



tcccagtgtc catatcgtgc ccagaaaagt agacattatc ctgccccatc ccttccccag     4560



tgcactctga cctagctagt gcctggtgcc cagtgacctg ggggagcctg gctgcaggcc     4620



ctcactggtt ccctaaacct tggtggctgt gattcaggtc cccagggggg actcagggag     4680



gaatatggct gagttctgta gtttccagag ttggctggta gagccttcta gaggttcaga     4740



atattagctt caggatcagc tgggggtatg gaattggctg aggatcaaac gtatgtaggt     4800



gaaaggatac caggatgttg ctaaaggtga gggacagttt gggtttggga cttaccgggg     4860



tgatgttaga tctggaaccc ccaagtgagg ctggagggag ttaaggtcag tatggaagat     4920



agggttggga cagggtgctt tggaatgaaa gagtgacctt agagggctcc ttgggcctca     4980



ggaatgctcc tgctgctgtg aagatgagaa ggtgctctta ctcagttaat gatgagtgac     5040



tatatttacc aaagccccta cctgctgctg ggtcccttgt agcacaggag actggggcta     5100



agggcccctc ccagggaagg gacaccatca ggcctctggc tgaggcagta gcatagagga     5160



tccatttcta cctgcatttc ccagaggact agcaggaggc agccttgaga aaccggcagt     5220



tcccaagcca gcgcctggct gttctctcat tgtcactgcc ctctccccaa cctctcctct     5280



aacccactag agattgcctg tgtcctgcct cttgcctctt gtagaatgca gctctggccc     5340



tcaataaatg cttcctgcat tcttctgcct cctgtgtcat tttc                      5384





<210>  276

<211>  903

<212>  PRT

<213>  Homo sapiens



<400>  276



Met Glu Gly Tyr Ser Glu Glu Ala Ser Leu Leu Arg His Leu Glu Lys 

1               5                   10                  15      





Val Ala Ser Glu Glu Glu Glu Val Pro Leu Val Val Tyr Leu Lys Glu 

            20                  25                  30          





Asn Ala Ala Leu Leu Thr Ala Asn Gly Leu His Leu Ser Gln Asn Arg 

        35                  40                  45              





Glu Ala Gln Gln Ser Ser Pro Ala Pro Pro Pro Ala Glu Val His Ser 

    50                  55                  60                  





Pro Ala Ala Asp Val Asn Gln Asn Leu Ala Ser Pro Ser Ala Thr Leu 

65                  70                  75                  80  





Thr Thr Pro Thr Ser Asn Ser Ser His Asn Pro Pro Ala Thr Asp Val 

                85                  90                  95      





Asn Gln Asn Pro Pro Ala Thr Val Val Pro Gln Ser Leu Pro Leu Ser 

            100                 105                 110         





Ser Ile Gln Gln Asn Ser Ser Glu Ala Gln Leu Pro Ser Asn Gly Thr 

        115                 120                 125             





Gly Pro Ala Ser Lys Pro Ser Thr Leu Cys Ala Asp Gly Gln Pro Gln 

    130                 135                 140                 





Ala Pro Ala Glu Glu Val Arg Cys Ser Thr Leu Leu Ile Asp Lys Val 

145                 150                 155                 160 





Ser Thr Pro Ala Thr Thr Thr Ser Thr Phe Ser Arg Glu Ala Thr Leu 

                165                 170                 175     





Ile Pro Ser Ser Arg Pro Pro Ala Ser Asp Phe Met Ser Ser Ser Leu 

            180                 185                 190         





Leu Ile Asp Ile Gln Pro Asn Thr Leu Val Val Ser Ala Asp Gln Glu 

        195                 200                 205             





Met Ser Gly Arg Ala Ala Ala Thr Thr Pro Thr Lys Val Tyr Ser Glu 

    210                 215                 220                 





Val His Phe Thr Leu Ala Lys Pro Pro Ser Val Val Asn Arg Thr Ala 

225                 230                 235                 240 





Arg Pro Phe Gly Ile Gln Ala Pro Gly Gly Thr Ser Gln Met Glu Arg 

                245                 250                 255     





Ser Pro Met Leu Glu Arg Arg His Phe Gly Glu Lys Ala Pro Ala Pro 

            260                 265                 270         





Gln Pro Pro Ser Leu Pro Asp Arg Ser Pro Arg Pro Gln Arg His Ile 

        275                 280                 285             





Met Ser Arg Ser Pro Met Val Glu Arg Arg Met Met Gly Gln Arg Ser 

    290                 295                 300                 





Pro Ala Ser Glu Arg Arg Pro Leu Gly Asn Phe Thr Ala Pro Pro Thr 

305                 310                 315                 320 





Tyr Thr Glu Thr Leu Ser Thr Ala Pro Leu Ala Ser Trp Val Arg Ser 

                325                 330                 335     





Pro Pro Ser Tyr Ser Val Leu Tyr Pro Ser Ser Asp Pro Lys Ser Ser 

            340                 345                 350         





His Leu Lys Gly Gln Ala Val Pro Ala Ser Lys Thr Gly Ile Leu Glu 

        355                 360                 365             





Glu Ser Met Ala Arg Arg Gly Ser Arg Lys Ser Met Phe Thr Phe Val 

    370                 375                 380                 





Glu Lys Pro Lys Val Thr Pro Asn Pro Asp Leu Leu Asp Leu Val Gln 

385                 390                 395                 400 





Thr Ala Asp Glu Lys Arg Arg Gln Arg Asp Gln Gly Glu Val Gly Val 

                405                 410                 415     





Glu Glu Glu Pro Phe Ala Leu Gly Ala Glu Ala Ser Asn Phe Gln Gln 

            420                 425                 430         





Glu Pro Ala Pro Arg Asp Arg Ala Ser Pro Ala Ala Ala Glu Glu Val 

        435                 440                 445             





Val Pro Glu Trp Ala Ser Cys Leu Lys Ser Pro Arg Ile Gln Ala Lys 

    450                 455                 460                 





Pro Lys Pro Lys Pro Asn Gln Asn Leu Ser Glu Ala Ser Gly Lys Gly 

465                 470                 475                 480 





Ala Glu Leu Tyr Ala Arg Arg Gln Ser Arg Met Glu Lys Tyr Val Ile 

                485                 490                 495     





Glu Ser Ser Ser His Thr Pro Glu Leu Ala Arg Cys Pro Ser Pro Thr 

            500                 505                 510         





Met Ser Leu Pro Ser Ser Trp Lys Tyr Pro Thr Asn Ala Pro Gly Ala 

        515                 520                 525             





Phe Arg Val Ala Ser Arg Ser Pro Ala Arg Thr Pro Pro Ala Ser Leu 

    530                 535                 540                 





Tyr His Gly Tyr Leu Pro Glu Asn Gly Val Leu Arg Pro Glu Pro Thr 

545                 550                 555                 560 





Lys Gln Pro Pro Tyr Gln Leu Arg Pro Ser Leu Phe Val Leu Ser Pro 

                565                 570                 575     





Ile Lys Glu Pro Ala Lys Val Ser Pro Arg Ala Ala Ser Pro Ala Lys 

            580                 585                 590         





Pro Ser Ser Leu Asp Leu Val Pro Asn Leu Pro Lys Gly Ala Leu Pro 

        595                 600                 605             





Pro Ser Pro Ala Leu Pro Arg Pro Ser Arg Ser Ser Pro Gly Leu Tyr 

    610                 615                 620                 





Thr Ser Pro Gly Gln Asp Ser Leu Gln Pro Thr Ala Val Ser Pro Pro 

625                 630                 635                 640 





Tyr Gly Gly Asp Ile Ser Pro Val Ser Pro Ser Arg Ala Trp Ser Pro 

                645                 650                 655     





Arg Ala Lys Gln Ala Pro Arg Pro Ser Phe Ser Thr Arg Asn Ala Gly 

            660                 665                 670         





Ile Glu Ala Gln Asp Arg Arg Glu Ser Leu Pro Thr Ser Pro Pro Trp 

        675                 680                 685             





Thr Pro Gly Ala Ser Arg Pro Pro Ser Ser Leu Asp Gly Trp Val Ser 

    690                 695                 700                 





Pro Gly Pro Trp Glu Pro Gly Arg Gly Ser Ser Met Ser Ser Pro Pro 

705                 710                 715                 720 





Pro Leu Pro Pro Pro Pro Pro Met Ser Pro Ser Trp Ser Glu Arg Ser 

                725                 730                 735     





Val Ser Pro Leu Arg Pro Glu Thr Glu Ala Arg Pro Pro Ser Arg Gln 

            740                 745                 750         





Leu Gln Ala Leu Leu Ala Arg Asn Ile Ile Asn Ala Ala Arg Arg Lys 

        755                 760                 765             





Ser Ala Ser Pro Arg Ser Ala Gly Ala Glu Asn Pro Arg Pro Phe Ser 

    770                 775                 780                 





Pro Pro Arg Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 

785                 790                 795                 800 





Arg Met Arg Ser Pro Gln Pro Ala Arg Pro Gly Ser Ala Ala Val Pro 

                805                 810                 815     





Gly Ala Ala Phe Ala Pro Ile Pro Arg Ser Pro Leu Pro Ala Gly Pro 

            820                 825                 830         





Ser Ser Cys Thr Ser Pro Arg Ser Pro Leu Pro Ala Pro Pro Arg Pro 

        835                 840                 845             





Phe Leu Tyr Arg Arg Ser Pro Thr Asp Ser Asp Val Ser Leu Asp Ser 

    850                 855                 860                 





Glu Asp Ser Gly Ala Lys Ser Pro Gly Ile Leu Gly Tyr Asn Ile Cys 

865                 870                 875                 880 





Pro Arg Gly Trp Asn Gly Ser Leu Arg Leu Lys Arg Gly Ser Leu Pro 

                885                 890                 895     





Ala Glu Ala Ser Cys Thr Thr 

            900             





<210>  277

<211>  2594

<212>  DNA

<213>  Homo sapiens



<400>  277

agccttcccc tggctccatg ggtttccccc tcccctgttg tatctaccct gccccagctc       60



ttccctgccc acccctcgct gactcgcttc gcttccccga cgcgctgggt tcccggagcg      120



cagagcccag cgttagcggg tgggctcccc gaggccccct gccctcgccg ggctgctcca      180



gggtgtcgct cctctggctg ctcccgaagg ggcttctggc cctgaggacg gtggtgccaa      240



gcgaacttca tttttaaaaa gaactggtgg atgagaagag cgagcgaggg cgagctatgg      300



accctgtgag tcagctggcc tctgcgggca ccttccgggt gctgaaggag ccccttgcct      360



tcctgcgagc cctggaattg ctttttgcaa tctttgcatt tgcaacatgc ggtggctatt      420



ctggaggcct gcggctgagt gtggactgcg tcaacaagac agaaagtaac ctcagcatcg      480



acatagcgtt tgcctaccca ttcaggttgc accaggtgac gtttgaggtg cccacctgcg      540



agggaaagga acggcagaag ctggcattga ttggtgactc ctcgtcttca gcagagttct      600



tcgtcactgt tgctgtcttc gccttcctct actctttggc tgccactgtc gtttacattt      660



tcttccagaa caaataccgg gaaaacaacc ggggcccact cattgacttc attgtcactg      720



tagtcttttc gttcttgtgg ttggtgggtt catcagcttg ggcaaaagga ctgtctgacg      780



tcaaagttgc aacggatccc aaggaagtat tgctactaat gtcagcttgc aaacagccat      840



ccaacaaatg catggctatc cacagccctg ttatgtcaag cttaaacact tctgtggtct      900



ttggattctt gaactttatt ctctgggctg gaaacatatg gtttgttttc aaggagaccg      960



gctggcattc ttcgggacag agatatcttt cagatccaat ggagaagcac tccagcagct     1020



ataatcaagg tggttacaac caagacagct atggatcaag cagtgggtac agtcagcagg     1080



cgagtttggg gccaacctca gatgagtttg gccaacagcc tactggcccc acttccttta     1140



ccaatcagat ttaacagagt agcatttgca ttcttctgca gtcgcctcac catcttccat     1200



ttcagtggca gaagaatttt ttaagggttt caatcaatta ttaatgcaga gagtattgaa     1260



tgtaaatcag agctctctag tcttcattaa ggcagcaagt cctgggttgt gaaaaatgat     1320



acttagagat gaggcgacat gaggagatat attattcatc atagatggct aattggagag     1380



taccttgtta tatatacaga tactttcatg gtcattttgt atgtatgtta aagtagtaga     1440



agtattttgt agcttaaagt ctctagtatg taatatgcat aaagtaaatc aaatagcgtt     1500



gagttttctt atgcattttg atgtgaaaga tgttataata atttctagaa gacaatttgg     1560



tgtatcacaa catgcatgtc ttattttttt ttagttttaa gtcctatagg actatgagtc     1620



tctaagttat ttgtttcaga aaattattct ttttttatgt gataaatcat atgatttaag     1680



tgcatgaata agcattttcc cacacaatga acatttgaac tgtgtttatg aaaattttct     1740



ggtttgcacc atgaatttgt caaatggata tttataggaa tatattcact actttgtata     1800



ctttgcaaat ttgtctctct ggctttaccc aagttctgaa tgcattgtaa ttaaaattta     1860



agtttttctt ttcccccatt agtaaacatt tagtgctaca tatgataact gcccaatatt     1920



tattctattt acttagctaa atatttgcat tcttgtaacc ttctatggtg ttttgtggct     1980



cttatcttgt ggaccataaa taacacggcc caataactct ttgtgtttat ggagtgttgt     2040



tttcttagaa taatggagat gcagatatag ataccatagt caaggtaccg ccttgctgaa     2100



gtatttattt ataaagaata ttctgtagaa cctctactac cagctatatt tttaaatcct     2160



gtttatttgt aaagctaata tgctcctcaa tgtaattatt aaaaattctc aagtcacagc     2220



taaacttact aattctgatt ttagtgtagc ccctaaatta aaaatggctt ccatatgcca     2280



ctctgtaccc caaagagagt tctcatgaaa tattctccag aatgtattca ttatcaagaa     2340



aatgtcaatc gtcacttcct cgttttaact cagctgaaac accaggaccc aatagagagg     2400



gcaagctgag catctgtatt tccagataaa agttgttatt gatgtataaa ctcgttgcgt     2460



gattagtgat gttggaagca ttttagcaca aaacagcctt gtgtcttaga tgatatctgt     2520



aaccagtttc tgaatcccgt tggataaaac tgtattgtga tatctatttg atgttaataa     2580



agttattgca taca                                                       2594





<210>  278

<211>  285

<212>  PRT

<213>  Homo sapiens



<400>  278



Met Asp Pro Val Ser Gln Leu Ala Ser Ala Gly Thr Phe Arg Val Leu 

1               5                   10                  15      





Lys Glu Pro Leu Ala Phe Leu Arg Ala Leu Glu Leu Leu Phe Ala Ile 

            20                  25                  30          





Phe Ala Phe Ala Thr Cys Gly Gly Tyr Ser Gly Gly Leu Arg Leu Ser 

        35                  40                  45              





Val Asp Cys Val Asn Lys Thr Glu Ser Asn Leu Ser Ile Asp Ile Ala 

    50                  55                  60                  





Phe Ala Tyr Pro Phe Arg Leu His Gln Val Thr Phe Glu Val Pro Thr 

65                  70                  75                  80  





Cys Glu Gly Lys Glu Arg Gln Lys Leu Ala Leu Ile Gly Asp Ser Ser 

                85                  90                  95      





Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr 

            100                 105                 110         





Ser Leu Ala Ala Thr Val Val Tyr Ile Phe Phe Gln Asn Lys Tyr Arg 

        115                 120                 125             





Glu Asn Asn Arg Gly Pro Leu Ile Asp Phe Ile Val Thr Val Val Phe 

    130                 135                 140                 





Ser Phe Leu Trp Leu Val Gly Ser Ser Ala Trp Ala Lys Gly Leu Ser 

145                 150                 155                 160 





Asp Val Lys Val Ala Thr Asp Pro Lys Glu Val Leu Leu Leu Met Ser 

                165                 170                 175     





Ala Cys Lys Gln Pro Ser Asn Lys Cys Met Ala Ile His Ser Pro Val 

            180                 185                 190         





Met Ser Ser Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Phe Ile 

        195                 200                 205             





Leu Trp Ala Gly Asn Ile Trp Phe Val Phe Lys Glu Thr Gly Trp His 

    210                 215                 220                 





Ser Ser Gly Gln Arg Tyr Leu Ser Asp Pro Met Glu Lys His Ser Ser 

225                 230                 235                 240 





Ser Tyr Asn Gln Gly Gly Tyr Asn Gln Asp Ser Tyr Gly Ser Ser Ser 

                245                 250                 255     





Gly Tyr Ser Gln Gln Ala Ser Leu Gly Pro Thr Ser Asp Glu Phe Gly 

            260                 265                 270         





Gln Gln Pro Thr Gly Pro Thr Ser Phe Thr Asn Gln Ile 

        275                 280                 285 





<210>  279

<211>  2632

<212>  DNA

<213>  Homo sapiens



<400>  279

aaagcagtcc tgcacttcca gttgtgagcc aagagccaag tgtgggagct caccatggtg       60



gcagccacct ccccaccaag caggcagcgt tcaccagagg ggagtatcag gttcctgtac      120



tcagctgtgg gttgtcactg tctaataata tgaccgtttt gccatctctc tgcaaatgag      180



gctgaagctg ctatctgatt ggtataacat ctcactttcc ctctgcattg attttcttct      240



tctcctcctt tgcttcataa aaagagggac aagtggctgg tgctgtggac agagaagctt      300



tatttttagt atgagacaac ctctattttc tttcaggaga gggaagttgg attatcaatt      360



cttttgtaaa tgtgtatggt gatatttgct ccgctttttg caatctttgc atttgcaaca      420



tgcggtggct attctggagg cctgcggctg agtgtggact gcgtcaacaa gacagaaagt      480



aacctcagca tcgacatagc gtttgcctac ccattcaggt tgcaccaggt gacgtttgag      540



gtgcccacct gcgagggaaa ggaacggcag aagctggcat tgattggtga ctcctcgtct      600



tcagcagagt tcttcgtcac tgttgctgtc ttcgccttcc tctactcttt ggctgccact      660



gtcgtttaca ttttcttcca gaacaaatac cgggaaaaca accggggccc actcattgac      720



ttcattgtca ctgtagtctt ttcgttcttg tggttggtgg gttcatcagc ttgggcaaaa      780



ggactgtctg acgtcaaagt tgcaacggat cccaaggaag tattgctact aatgtcagct      840



tgcaaacagc catccaacaa atgcatggct atccacagcc ctgttatgtc aagcttaaac      900



acttctgtgg tctttggatt cttgaacttt attctctggg ctggaaacat atggtttgtt      960



ttcaaggaga ccggctggca ttcttcggga cagagatatc tttcagatcc aatggagaag     1020



cactccagca gctataatca aggtggttac aaccaagaca gctatggatc aagcagtggg     1080



tacagtcagc aggcgagttt ggggccaacc tcagatgagt ttggccaaca gcctactggc     1140



cccacttcct ttaccaatca gatttaacag agtagcattt gcattcttct gcagtcgcct     1200



caccatcttc catttcagtg gcagaagaat tttttaaggg tttcaatcaa ttattaatgc     1260



agagagtatt gaatgtaaat cagagctctc tagtcttcat taaggcagca agtcctgggt     1320



tgtgaaaaat gatacttaga gatgaggcga catgaggaga tatattattc atcatagatg     1380



gctaattgga gagtaccttg ttatatatac agatactttc atggtcattt tgtatgtatg     1440



ttaaagtagt agaagtattt tgtagcttaa agtctctagt atgtaatatg cataaagtaa     1500



atcaaatagc gttgagtttt cttatgcatt ttgatgtgaa agatgttata ataatttcta     1560



gaagacaatt tggtgtatca caacatgcat gtcttatttt tttttagttt taagtcctat     1620



aggactatga gtctctaagt tatttgtttc agaaaattat tcttttttta tgtgataaat     1680



catatgattt aagtgcatga ataagcattt tcccacacaa tgaacatttg aactgtgttt     1740



atgaaaattt tctggtttgc accatgaatt tgtcaaatgg atatttatag gaatatattc     1800



actactttgt atactttgca aatttgtctc tctggcttta cccaagttct gaatgcattg     1860



taattaaaat ttaagttttt cttttccccc attagtaaac atttagtgct acatatgata     1920



actgcccaat atttattcta tttacttagc taaatatttg cattcttgta accttctatg     1980



gtgttttgtg gctcttatct tgtggaccat aaataacacg gcccaataac tctttgtgtt     2040



tatggagtgt tgttttctta gaataatgga gatgcagata tagataccat agtcaaggta     2100



ccgccttgct gaagtattta tttataaaga atattctgta gaacctctac taccagctat     2160



atttttaaat cctgtttatt tgtaaagcta atatgctcct caatgtaatt attaaaaatt     2220



ctcaagtcac agctaaactt actaattctg attttagtgt agcccctaaa ttaaaaatgg     2280



cttccatatg ccactctgta ccccaaagag agttctcatg aaatattctc cagaatgtat     2340



tcattatcaa gaaaatgtca atcgtcactt cctcgtttta actcagctga aacaccagga     2400



cccaatagag agggcaagct gagcatctgt atttccagat aaaagttgtt attgatgtat     2460



aaactcgttg cgtgattagt gatgttggaa gcattttagc acaaaacagc cttgtgtctt     2520



agatgatatc tgtaaccagt ttctgaatcc cgttggataa aactgtattg tgatatctat     2580



ttgatgttaa taaagttatt gcatacaaaa aaaaaaaaaa aaaaaaaaaa aa             2632





<210>  280

<211>  265

<212>  PRT

<213>  Homo sapiens



<400>  280



Met Cys Met Val Ile Phe Ala Pro Leu Phe Ala Ile Phe Ala Phe Ala 

1               5                   10                  15      





Thr Cys Gly Gly Tyr Ser Gly Gly Leu Arg Leu Ser Val Asp Cys Val 

            20                  25                  30          





Asn Lys Thr Glu Ser Asn Leu Ser Ile Asp Ile Ala Phe Ala Tyr Pro 

        35                  40                  45              





Phe Arg Leu His Gln Val Thr Phe Glu Val Pro Thr Cys Glu Gly Lys 

    50                  55                  60                  





Glu Arg Gln Lys Leu Ala Leu Ile Gly Asp Ser Ser Ser Ser Ala Glu 

65                  70                  75                  80  





Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr Ser Leu Ala Ala 

                85                  90                  95      





Thr Val Val Tyr Ile Phe Phe Gln Asn Lys Tyr Arg Glu Asn Asn Arg 

            100                 105                 110         





Gly Pro Leu Ile Asp Phe Ile Val Thr Val Val Phe Ser Phe Leu Trp 

        115                 120                 125             





Leu Val Gly Ser Ser Ala Trp Ala Lys Gly Leu Ser Asp Val Lys Val 

    130                 135                 140                 





Ala Thr Asp Pro Lys Glu Val Leu Leu Leu Met Ser Ala Cys Lys Gln 

145                 150                 155                 160 





Pro Ser Asn Lys Cys Met Ala Ile His Ser Pro Val Met Ser Ser Leu 

                165                 170                 175     





Asn Thr Ser Val Val Phe Gly Phe Leu Asn Phe Ile Leu Trp Ala Gly 

            180                 185                 190         





Asn Ile Trp Phe Val Phe Lys Glu Thr Gly Trp His Ser Ser Gly Gln 

        195                 200                 205             





Arg Tyr Leu Ser Asp Pro Met Glu Lys His Ser Ser Ser Tyr Asn Gln 

    210                 215                 220                 





Gly Gly Tyr Asn Gln Asp Ser Tyr Gly Ser Ser Ser Gly Tyr Ser Gln 

225                 230                 235                 240 





Gln Ala Ser Leu Gly Pro Thr Ser Asp Glu Phe Gly Gln Gln Pro Thr 

                245                 250                 255     





Gly Pro Thr Ser Phe Thr Asn Gln Ile 

            260                 265 





<210>  281

<211>  4647

<212>  DNA

<213>  Homo sapiens



<400>  281

atggcggcgg gctcggatct gctggacgag gtcttcttca acagcgaggt ggacgagaaa       60



gtggtgagcg acctggtggg ctcgctggag tcgcagctgg cggccagcgc ggcccaccac      120



caccacctcg cgccgcgcac gcccgaggtg cgggccgcgg ccgccggcgc gctcgggaac      180



catgttgtga gcggcagccc ggccggagcc gcgggcgcag ggccggccgc ccccgccgag      240



ggcgcgcccg gagcggcgcc ggagccgccc cccgcaggta gagcgcggcc ggggggcggg      300



gggccgcagc gcccgggccc cccctcaccg cgccgccccc ttgtccccgc agggcccgcg      360



ccgcccgccg cgaagctgag gccgccgccc gagggcagcg cggggtcctg cgccccggtg      420



cccgccgccg ccgccgtcgc cgcggggccc gagcccgccc ccgccggccc cgccaagccc      480



gccggccccg ccgcgctggc cgcccgcgcc ggccccggcc ccgggcccgg ccccggcccc      540



ggccccggcc ctggccctgg caagcccgcc ggccccggcg ccgcgcaaac tttgaatggg      600



agcgccgcgc tgctgaactc gcaccacgcc gccgcacctg ctgtcagcct ggtcaacaac      660



gggcccgccg cgctgctgcc gctgcccaag cccgccgccc ccggcactgt catccagacg      720



ccccccttcg tgggcgccgc cgcgcccccc gcgcccgccg cgccctcgcc ccccgccgcc      780



cccgcgcccg ccgcccccgc cgccgccccg cccccgccac cccccgcgcc cgccactctg      840



gcccggccgc ccggccaccc cgccggaccc ccgaccgccg cgcccgccgt gccgcccccc      900



gccgccgccc agaacggggg cagcgccggg gcagcccccg cccccgcccc ggccgccggg      960



ggccccgcgg gggtcagcgg ccaacccggg cccggcgcgg cggctgcggc gccggcgccg     1020



ggggtcaagg ccgagtcgcc caagagggtg gtgcaggcgg cgcccccggc ggcgcagacc     1080



ctggcggcca gcggcccggc cagcacggcg gccagcatgg tcatcgggcc aactatgcaa     1140



ggggcgctgc ccagcccggc cgccgtcccg ccgcccgccc ccgggacccc caccgggctg     1200



cccaaaggcg cggccggcgc agtgacccag agcctgtccc ggacgcccac ggccaccacc     1260



agcgggattc gggccaccct gacgcccacc gtgctggccc cccgcttgcc gcagccgcct     1320



cagaacccga ccaacatcca gaacttccag ctgcccccag gaatggtcct cgtccgaagt     1380



gagaatgggc agttgttaat gattcctcag caggccttgg cccagatgca ggcgcaggcc     1440



catgcccagc ctcagaccac catggcgcct cgccctgcca cccccacaag tgcccctccc     1500



gtccagatct ccaccgtaca ggcacctgga acacctatca ttgcacggca ggtgacccca     1560



actaccataa ttaagcaagt gtctcaggcc cagacaacgg tgcagcccag tgcaaccctg     1620



cagcgctcgc ccggcgtcca gcctcagctc gttctgggtg gcgctgccca gacggcttca     1680



cttgggacgg cgacggctgt tcagacgggg actcctcagc gcacggtacc aggggcgacc     1740



accacttcct cagctgccac ggaaactatg gaaaacgtga agaaatgtaa aaatttccta     1800



tctacgttaa taaaactggc ttcatctggc aagcagtcta cagagacagc agctaatgtg     1860



aaagagctcg tgcagaattt actggatgga aaaatagaag cagaagattt cacaagcagg     1920



ttataccgag aacttaattc ttcacctcaa ccttaccttg tgcctttcct gaagaggagc     1980



ttacccgcct tgagacagct gacccccgac tccgcggcct tcatccagca gagccagcag     2040



cagccgccac cgcccacctc gcaggccacc actgcgctca cggccgtggt gctgagtagc     2100



tcggtccagc gcacggccgg gaagacggcg gccaccgtga ccagtgccct ccagccccct     2160



gtgctcagcc tcacgcagcc cacgcaggtc ggcgtcggca agcaggggca acccacaccg     2220



ctggtcatcc agcagcctcc gaagccagga gccctgatcc ggcccccgca ggtgacgttg     2280



acgcagacac ccatggtcgc cctgcggcag cctcacaacc ggatcatgct caccacgcct     2340



cagcagatcc agctgaaccc actgcagcca gtccctgtgg tgaaacccgc cgtgttacct     2400



ggaaccaaag ccctttctgc tgtctcggca caagcagctg ctgcacagaa aaataaactc     2460



aaggagcctg ggggaggttc gtttcgggac gatgatgaca ttaatgatgt tgcatcgatg     2520



gctggagtaa acttgtcaga agaaagtgca agaatattag ccacgaactc tgaattggtg     2580



ggcacgctaa cgcggtcctg taaagatgaa accttcctcc tccaagcgcc tttgcagaga     2640



agaatattag aaataggtaa aaaacatggt ataacggaat tacatccaga tgtagtaagt     2700



tatgtatcac atgccacgca acaaaggcta cagaatcttg tagagaaaat atcagaaaca     2760



gctcagcaga agaacttttc ttacaaggat gacgacagat atgagcaggc gagtgacgtc     2820



cgggcacagc tcaagttttt tgaacagctt gatcaaatcg aaaagcagag gaaggatgag     2880



caggagcggg agatcctgat gagggcagca aagtctcggt caagacaaga agatccagaa     2940



cagttaaggc tgaaacagaa ggcaaaggag atgcagcaac aggaactggc acaaatgaga     3000



cagcgggacg ccaacctcac agcactagca gcgatcgggc ccaggaaaaa gaggaaagtg     3060



gactgtccgg ggccgggctc aggagcagag gggtcgggcc ccggctcagt ggtcccaggc     3120



agctcgggtg tcggaacccc cagacagttc acgcgacaaa gaatcacgcg ggtcaacctc     3180



agggacctca tattttgttt agaaaatgaa cgtgagacaa gccattcact gctgctctac     3240



aaagcattcc ttaagtgaca caggaggacg cctggggact ttttatatat ttgcagatta     3300



cgcctttttg taacgagcaa atgggatatt gtttaaaaaa cagccacctc tttacaatgg     3360



aacagtttta tattcctgtt tctaaatcag ctcttcagtg tgaaagaaaa cacgtttctg     3420



taacagagag aacacaaagg cctgtggata ctcttaaagg acaattaaat cttaactcat     3480



cttgattgag tggccttcct gccaaacaag ccatatataa agactgatgg aatcgttagc     3540



aaataattag ctgccctctg tcaactcata gcagtttctg cattatttgt gcattttggt     3600



ttagttctac ctaacttact atgtaggtgt atgtctacag ccgatgacct catttcgttt     3660



attttatttt tgtaatagtc agttggcaaa gcaaactgat tttttagact atttatcttc     3720



cttcccttcc cctcccaccc cgctctcctc tctgccccct gccctcccct cccctccctt     3780



cccctccact ccgctgagaa tcctggagga atacacaatt catcgttgca cccccacctc     3840



agagtgtaat cgcatttctg cttggtagag gccgagccca gcaaaggtgg ctccttctga     3900



atgtgtggtc agcatctgta caaatgcatt ttatttgcta tagtttgtaa agctgtaaag     3960



ttaaaagaga tgaaaacctt ttcagcataa atatatttta cttgcactgt gttttttagc     4020



taaaagtgaa aacctagatt aaataaaatc aaagttgaga agaatcatca aaagactgtt     4080



tctcggtgtg aatcaagtgt tgaaaaatgg ttggtgtatt ttgtcagtaa ttgtacataa     4140



cttttggcac atgacataga aatggctatg taaactataa ttattttgct aagagactgt     4200



atgcaagcct tgggccgact ttacagacgt ccagagcaaa gccccttctt tgtacctatt     4260



tttttattac aaatatacta attggttctt tctattttca gaggttattg tatgaaattg     4320



tctattgata gtacttttat gactgtaaat actctggctt tctccgtgtg aattctcaca     4380



ttagacttta attcgagcgc gtgtgaactg aacgctgatc agtatttttt atcaacacct     4440



gagaactgtt acacctttta ttttgtcttt taggaaatcc ctgtctttcc attttttcat     4500



gtaaattttg cacagttact tgttcatatg taaatatttt actttcagaa atgaagtttt     4560



taattgctat tgttttatat aggattgaaa gaaaattaac tcctttatta aaaacaaatt     4620



tatctgtaaa aaaaaaaaaa aaaaaaa                                         4647





<210>  282

<211>  1085

<212>  PRT

<213>  Homo sapiens



<400>  282



Met Ala Ala Gly Ser Asp Leu Leu Asp Glu Val Phe Phe Asn Ser Glu 

1               5                   10                  15      





Val Asp Glu Lys Val Val Ser Asp Leu Val Gly Ser Leu Glu Ser Gln 

            20                  25                  30          





Leu Ala Ala Ser Ala Ala His His His His Leu Ala Pro Arg Thr Pro 

        35                  40                  45              





Glu Val Arg Ala Ala Ala Ala Gly Ala Leu Gly Asn His Val Val Ser 

    50                  55                  60                  





Gly Ser Pro Ala Gly Ala Ala Gly Ala Gly Pro Ala Ala Pro Ala Glu 

65                  70                  75                  80  





Gly Ala Pro Gly Ala Ala Pro Glu Pro Pro Pro Ala Gly Arg Ala Arg 

                85                  90                  95      





Pro Gly Gly Gly Gly Pro Gln Arg Pro Gly Pro Pro Ser Pro Arg Arg 

            100                 105                 110         





Pro Leu Val Pro Ala Gly Pro Ala Pro Pro Ala Ala Lys Leu Arg Pro 

        115                 120                 125             





Pro Pro Glu Gly Ser Ala Gly Ser Cys Ala Pro Val Pro Ala Ala Ala 

    130                 135                 140                 





Ala Val Ala Ala Gly Pro Glu Pro Ala Pro Ala Gly Pro Ala Lys Pro 

145                 150                 155                 160 





Ala Gly Pro Ala Ala Leu Ala Ala Arg Ala Gly Pro Gly Pro Gly Pro 

                165                 170                 175     





Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Lys Pro Ala Gly Pro 

            180                 185                 190         





Gly Ala Ala Gln Thr Leu Asn Gly Ser Ala Ala Leu Leu Asn Ser His 

        195                 200                 205             





His Ala Ala Ala Pro Ala Val Ser Leu Val Asn Asn Gly Pro Ala Ala 

    210                 215                 220                 





Leu Leu Pro Leu Pro Lys Pro Ala Ala Pro Gly Thr Val Ile Gln Thr 

225                 230                 235                 240 





Pro Pro Phe Val Gly Ala Ala Ala Pro Pro Ala Pro Ala Ala Pro Ser 

                245                 250                 255     





Pro Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Pro 

            260                 265                 270         





Pro Pro Pro Ala Pro Ala Thr Leu Ala Arg Pro Pro Gly His Pro Ala 

        275                 280                 285             





Gly Pro Pro Thr Ala Ala Pro Ala Val Pro Pro Pro Ala Ala Ala Gln 

    290                 295                 300                 





Asn Gly Gly Ser Ala Gly Ala Ala Pro Ala Pro Ala Pro Ala Ala Gly 

305                 310                 315                 320 





Gly Pro Ala Gly Val Ser Gly Gln Pro Gly Pro Gly Ala Ala Ala Ala 

                325                 330                 335     





Ala Pro Ala Pro Gly Val Lys Ala Glu Ser Pro Lys Arg Val Val Gln 

            340                 345                 350         





Ala Ala Pro Pro Ala Ala Gln Thr Leu Ala Ala Ser Gly Pro Ala Ser 

        355                 360                 365             





Thr Ala Ala Ser Met Val Ile Gly Pro Thr Met Gln Gly Ala Leu Pro 

    370                 375                 380                 





Ser Pro Ala Ala Val Pro Pro Pro Ala Pro Gly Thr Pro Thr Gly Leu 

385                 390                 395                 400 





Pro Lys Gly Ala Ala Gly Ala Val Thr Gln Ser Leu Ser Arg Thr Pro 

                405                 410                 415     





Thr Ala Thr Thr Ser Gly Ile Arg Ala Thr Leu Thr Pro Thr Val Leu 

            420                 425                 430         





Ala Pro Arg Leu Pro Gln Pro Pro Gln Asn Pro Thr Asn Ile Gln Asn 

        435                 440                 445             





Phe Gln Leu Pro Pro Gly Met Val Leu Val Arg Ser Glu Asn Gly Gln 

    450                 455                 460                 





Leu Leu Met Ile Pro Gln Gln Ala Leu Ala Gln Met Gln Ala Gln Ala 

465                 470                 475                 480 





His Ala Gln Pro Gln Thr Thr Met Ala Pro Arg Pro Ala Thr Pro Thr 

                485                 490                 495     





Ser Ala Pro Pro Val Gln Ile Ser Thr Val Gln Ala Pro Gly Thr Pro 

            500                 505                 510         





Ile Ile Ala Arg Gln Val Thr Pro Thr Thr Ile Ile Lys Gln Val Ser 

        515                 520                 525             





Gln Ala Gln Thr Thr Val Gln Pro Ser Ala Thr Leu Gln Arg Ser Pro 

    530                 535                 540                 





Gly Val Gln Pro Gln Leu Val Leu Gly Gly Ala Ala Gln Thr Ala Ser 

545                 550                 555                 560 





Leu Gly Thr Ala Thr Ala Val Gln Thr Gly Thr Pro Gln Arg Thr Val 

                565                 570                 575     





Pro Gly Ala Thr Thr Thr Ser Ser Ala Ala Thr Glu Thr Met Glu Asn 

            580                 585                 590         





Val Lys Lys Cys Lys Asn Phe Leu Ser Thr Leu Ile Lys Leu Ala Ser 

        595                 600                 605             





Ser Gly Lys Gln Ser Thr Glu Thr Ala Ala Asn Val Lys Glu Leu Val 

    610                 615                 620                 





Gln Asn Leu Leu Asp Gly Lys Ile Glu Ala Glu Asp Phe Thr Ser Arg 

625                 630                 635                 640 





Leu Tyr Arg Glu Leu Asn Ser Ser Pro Gln Pro Tyr Leu Val Pro Phe 

                645                 650                 655     





Leu Lys Arg Ser Leu Pro Ala Leu Arg Gln Leu Thr Pro Asp Ser Ala 

            660                 665                 670         





Ala Phe Ile Gln Gln Ser Gln Gln Gln Pro Pro Pro Pro Thr Ser Gln 

        675                 680                 685             





Ala Thr Thr Ala Leu Thr Ala Val Val Leu Ser Ser Ser Val Gln Arg 

    690                 695                 700                 





Thr Ala Gly Lys Thr Ala Ala Thr Val Thr Ser Ala Leu Gln Pro Pro 

705                 710                 715                 720 





Val Leu Ser Leu Thr Gln Pro Thr Gln Val Gly Val Gly Lys Gln Gly 

                725                 730                 735     





Gln Pro Thr Pro Leu Val Ile Gln Gln Pro Pro Lys Pro Gly Ala Leu 

            740                 745                 750         





Ile Arg Pro Pro Gln Val Thr Leu Thr Gln Thr Pro Met Val Ala Leu 

        755                 760                 765             





Arg Gln Pro His Asn Arg Ile Met Leu Thr Thr Pro Gln Gln Ile Gln 

    770                 775                 780                 





Leu Asn Pro Leu Gln Pro Val Pro Val Val Lys Pro Ala Val Leu Pro 

785                 790                 795                 800 





Gly Thr Lys Ala Leu Ser Ala Val Ser Ala Gln Ala Ala Ala Ala Gln 

                805                 810                 815     





Lys Asn Lys Leu Lys Glu Pro Gly Gly Gly Ser Phe Arg Asp Asp Asp 

            820                 825                 830         





Asp Ile Asn Asp Val Ala Ser Met Ala Gly Val Asn Leu Ser Glu Glu 

        835                 840                 845             





Ser Ala Arg Ile Leu Ala Thr Asn Ser Glu Leu Val Gly Thr Leu Thr 

    850                 855                 860                 





Arg Ser Cys Lys Asp Glu Thr Phe Leu Leu Gln Ala Pro Leu Gln Arg 

865                 870                 875                 880 





Arg Ile Leu Glu Ile Gly Lys Lys His Gly Ile Thr Glu Leu His Pro 

                885                 890                 895     





Asp Val Val Ser Tyr Val Ser His Ala Thr Gln Gln Arg Leu Gln Asn 

            900                 905                 910         





Leu Val Glu Lys Ile Ser Glu Thr Ala Gln Gln Lys Asn Phe Ser Tyr 

        915                 920                 925             





Lys Asp Asp Asp Arg Tyr Glu Gln Ala Ser Asp Val Arg Ala Gln Leu 

    930                 935                 940                 





Lys Phe Phe Glu Gln Leu Asp Gln Ile Glu Lys Gln Arg Lys Asp Glu 

945                 950                 955                 960 





Gln Glu Arg Glu Ile Leu Met Arg Ala Ala Lys Ser Arg Ser Arg Gln 

                965                 970                 975     





Glu Asp Pro Glu Gln Leu Arg Leu Lys Gln Lys Ala Lys Glu Met Gln 

            980                 985                 990         





Gln Gln Glu Leu Ala Gln Met Arg  Gln Arg Asp Ala Asn  Leu Thr Ala 

        995                 1000                 1005             





Leu Ala  Ala Ile Gly Pro Arg  Lys Lys Arg Lys Val  Asp Cys Pro 

    1010                 1015                 1020             





Gly Pro  Gly Ser Gly Ala Glu  Gly Ser Gly Pro Gly  Ser Val Val 

    1025                 1030                 1035             





Pro Gly  Ser Ser Gly Val Gly  Thr Pro Arg Gln Phe  Thr Arg Gln 

    1040                 1045                 1050             





Arg Ile  Thr Arg Val Asn Leu  Arg Asp Leu Ile Phe  Cys Leu Glu 

    1055                 1060                 1065             





Asn Glu  Arg Glu Thr Ser His  Ser Leu Leu Leu Tyr  Lys Ala Phe 

    1070                 1075                 1080             





Leu Lys  

    1085 





<210>  283

<211>  4447

<212>  DNA

<213>  Homo sapiens



<400>  283

ggagacgctg ggcgcgctgt ggggcggggg cgaggttcgg gctggttgtt ccgttgcgag       60



ctgcagctgc gatctctgtg gtaggcccag aagtgtatgc tgacttgtaa agtgaagaag      120



ccagtggtgc tgcgggtgtt cttttggggt agtgtctggg atccagtacg agttgaatca      180



ttgttcaaat aaggtgtaat tgaaaagtga tcctctcttc agagatgtca aaaacaaaca      240



aatccaagtc tggatctcgc tcttctcgct caagatctgc atcaagatct cgttctcgtt      300



cattttcgaa gtctcggtcc cgaagccgat ctctctctcg ttcaaggaag cgcaggctga      360



gttctaggtc tcgttccaga tcatattctc cagctcataa cagagaaaga aaccacccaa      420



gagtatatca gaatcgggat ttccgaggtc acaacagagg ctatagaagg ccctattatt      480



tccgtgggcg taacagaggc ttttatccat ggggccaata taaccgagga ggctatggaa      540



actaccgctc aaattggcag aattaccggc aagcatacag tcctcgtcga ggccgttcaa      600



gatcccggtc cccaaagaga aggtcccctt caccaaggtc caggagccat tctagaaact      660



ctgataagtc gtcttctgac cggtcaaggc gctcctcatc ctcccgttct tcctccaacc      720



atagccgagt tgaatcttct aagcgcaagt ctgcaaagga gaaaaagtcc tcttctaagg      780



atagccggcc atctcaggct gccggggata accagggaga tgaggccaag gagcagacat      840



tctctggagg cacctctcaa gatacaaaag catctgagag ctcgaagcca tggccagatg      900



ccacctacgg cactggttct gcatcacggg cctcagcagt ttctgagctg agtcctcggg      960



agcgaagccc agctctcaaa agccccctcc agtctgtggt ggtgaggcgg cggtcacccc     1020



gtcctagccc cgtgccaaaa cctagtcctc cactttccag cacatcccag atgggctcaa     1080



ctctgccgag tggtgccggg tatcagtctg ggacacacca aggtcagttc gaccatggtt     1140



ctgggtccct gagtccatcc aaaaagagcc ctgtgggtaa gagtccacca tccactggct     1200



ccacatatgg ctcatctcag aaggaggaga gtgctgcttc aggaggagca gcctatacaa     1260



agaggtatct agaagagcag aagacagaga atggaaaaga taaggaacag aaacaaacaa     1320



ataccgataa agaaaaaata aaagagaaag ggagcttctc tgacacaggc ttgggtgatg     1380



gaaaaatgaa atctgattct tttgctccca aaactgattc tgagaagcct tttcggggca     1440



gtcagtctcc caaaaggtat aagctccgag atgactttga gaagaagatg gctgacttcc     1500



acaaggagga gatggatgat caagataagg acaaagctaa gggaagaaag gaatctgagt     1560



ttgatgatga acccaaattt atgtctaaag tcataggtgc aaacaaaaac caggaggagg     1620



agaagtcagg caaatgggag ggcctggtat atgcacctcc agggaaggaa aagcagagaa     1680



aaacagagga gctggaggag gagtctttcc cagagagatc caaaaaggaa gatcggggca     1740



agagaagcga aggtgggcac aggggctttg tgcctgagaa gaatttccga gtgactgctt     1800



ataaagcagt ccaggagaaa agctcatcac ctcccccaag aaagacctct gagagccgag     1860



acaagctggg agcgaaagga gattttccca caggaaagtc ttccttttcc attactcgag     1920



aggcacaggt caatgtccgg atggactctt ttgatgagga cctcgcacga cccagtggct     1980



tattggctca ggaacgcaag ctttgccgag atctagtcca tagcaacaaa aaggaacagg     2040



agtttcgttc cattttccag cacatacaat cagctcagtc tcagcgtagc ccctcagaac     2100



tgtttgccca acatatagtg accattgttc accatgttaa agagcatcac tttgggtcct     2160



caggaatgac attacatgaa cgctttacta aatacctaaa gagaggaact gagcaggagg     2220



cagccaaaaa caagaaaagc ccagagatac acaggagaat agacatttcc cccagtacat     2280



tcagaaaaca tggtttggct catgatgaaa tgaaaagtcc ccgggaacct ggctacaagg     2340



ctgagggaaa atacaaagat gatcctgttg atctccgcct tgatattgaa cgtcgtaaaa     2400



aacataagga gagagatctt aaacgaggta aatcgagaga atcagtggat tcccgagact     2460



ccagtcactc aagggaaagg tcagctgaaa aaacagagaa aactcataaa ggatcaaaga     2520



aacagaagaa gcatcggaga gcaagagaca ggtccagatc ctcctcctct tcctcccagt     2580



catctcactc ctacaaagca gaagagtaca ctgaagagac agaggaaaga gaggagagca     2640



ccacgggctt tgacaaatca agactgggga ccaaagactt tgtgggtcca agtgaaagag     2700



gaggtggcag agctcgagga acctttcagt ttcgagccag aggaagaggc tggggcagag     2760



gcaactactc tgggaacaat aacaacaaca gcaacaacga ttttcaaaaa agaaaccggg     2820



aagaggagtg ggacccagag tacacaccca aaagcaagaa gtattacttg catgatgacc     2880



gtgaaggcga aggcagtgac aagtgggtga gccggggccg gggccgagga gcctttcctc     2940



ggggtcgggg ccggttcatg ttccggaaat caagtaccag ccccaagtgg gcccatgaca     3000



agttcagtgg ggaggaaggg gagattgaag acgacgagag tgggacagag aaccgagaag     3060



agaaggacaa tatacagccc acaaccgagt aggggccacc cttgacggga ttcctgccca     3120



ggggagagag gcgctgggaa gatggctggt gaggagctta acagaggaac ctcaagaaga     3180



ttctgaaaat cctaccccca ccccccacca gccgcacaga ttgtactacc gcgagaggca     3240



tccctggcgc tgtctcccac tggacagagg aggctggcca tggggcccag gggtcaggcc     3300



cagcttttga gcagaataca acgcattggg ctttagctgt ttttctcatt tgttggtgtg     3360



tggggtgggg gcaggggtag ggcgggagag cgatgcttgg atttttgttt cctattagaa     3420



accaacagtt ttgttctaat ttcatttcat ttggagctaa gatgactaat ttgatgattt     3480



tcgatctctt ttcccctgtc ctgattttaa aagccccctc cttttttttt ttttttttct     3540



ttttttaggc atatgtagta atattagaaa catttaattt gggaaacttt gattcttgaa     3600



agagaaaaca aaagcatgtg aataaacttt gaagtgttca cctcagtttg ggaccaaact     3660



gcttggatct ttgtaaaaac cggttttgta tgtcaaggag gagtttaagg cctttccgac     3720



caccttgtgt tccccttttc tgcgcagcca tgtatcacgt ggagttgctc cttaccacac     3780



ctcacgtgcc cctgagccct atttcctgat ttcttctggg ctggacttcc ccgttctcca     3840



ccagcagctc cagtatccca aactttctag tcctgctgat cctcccagca acggggtgga     3900



aactggaggg cagtgtctgg tctgttttct aagaaactta tgaattctat tatctttaca     3960



aatatgagaa aattttttca atatttttta ttaatctttt tataaaatga aaagaaactc     4020



ctatgatcga ttaaggaagg tggttatggc tgggtggttc aggggttttt ttgggtttct     4080



tttttttttt ctttgtcttt ttaaccttaa gctgtttaag ttgaagcatt ctcagatgtt     4140



tggggggaaa catcctctta aaatgggtcc ttgtgcttgc cttctgggga ggcggtcctg     4200



agcaggtgaa tcataaggca tttatgcata tgttatatgc ggactgcacc cacctctccc     4260



ccccagcctt tgcctcttgc gttgttgtgc tgctttcccc ttactttgct acatttctat     4320



agttaagttg gttttacttg aatgattcat gtttaggggg aaaatgaaaa tctcccttaa     4380



aatttgtttc aactcctcct gcaaataaaa taaatgaagt ggcagatgta aaaaaaaaaa     4440



aaaaaaa                                                               4447





<210>  284

<211>  955

<212>  PRT

<213>  Homo sapiens



<400>  284



Met Ser Lys Thr Asn Lys Ser Lys Ser Gly Ser Arg Ser Ser Arg Ser 

1               5                   10                  15      





Arg Ser Ala Ser Arg Ser Arg Ser Arg Ser Phe Ser Lys Ser Arg Ser 

            20                  25                  30          





Arg Ser Arg Ser Leu Ser Arg Ser Arg Lys Arg Arg Leu Ser Ser Arg 

        35                  40                  45              





Ser Arg Ser Arg Ser Tyr Ser Pro Ala His Asn Arg Glu Arg Asn His 

    50                  55                  60                  





Pro Arg Val Tyr Gln Asn Arg Asp Phe Arg Gly His Asn Arg Gly Tyr 

65                  70                  75                  80  





Arg Arg Pro Tyr Tyr Phe Arg Gly Arg Asn Arg Gly Phe Tyr Pro Trp 

                85                  90                  95      





Gly Gln Tyr Asn Arg Gly Gly Tyr Gly Asn Tyr Arg Ser Asn Trp Gln 

            100                 105                 110         





Asn Tyr Arg Gln Ala Tyr Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg 

        115                 120                 125             





Ser Pro Lys Arg Arg Ser Pro Ser Pro Arg Ser Arg Ser His Ser Arg 

    130                 135                 140                 





Asn Ser Asp Lys Ser Ser Ser Asp Arg Ser Arg Arg Ser Ser Ser Ser 

145                 150                 155                 160 





Arg Ser Ser Ser Asn His Ser Arg Val Glu Ser Ser Lys Arg Lys Ser 

                165                 170                 175     





Ala Lys Glu Lys Lys Ser Ser Ser Lys Asp Ser Arg Pro Ser Gln Ala 

            180                 185                 190         





Ala Gly Asp Asn Gln Gly Asp Glu Ala Lys Glu Gln Thr Phe Ser Gly 

        195                 200                 205             





Gly Thr Ser Gln Asp Thr Lys Ala Ser Glu Ser Ser Lys Pro Trp Pro 

    210                 215                 220                 





Asp Ala Thr Tyr Gly Thr Gly Ser Ala Ser Arg Ala Ser Ala Val Ser 

225                 230                 235                 240 





Glu Leu Ser Pro Arg Glu Arg Ser Pro Ala Leu Lys Ser Pro Leu Gln 

                245                 250                 255     





Ser Val Val Val Arg Arg Arg Ser Pro Arg Pro Ser Pro Val Pro Lys 

            260                 265                 270         





Pro Ser Pro Pro Leu Ser Ser Thr Ser Gln Met Gly Ser Thr Leu Pro 

        275                 280                 285             





Ser Gly Ala Gly Tyr Gln Ser Gly Thr His Gln Gly Gln Phe Asp His 

    290                 295                 300                 





Gly Ser Gly Ser Leu Ser Pro Ser Lys Lys Ser Pro Val Gly Lys Ser 

305                 310                 315                 320 





Pro Pro Ser Thr Gly Ser Thr Tyr Gly Ser Ser Gln Lys Glu Glu Ser 

                325                 330                 335     





Ala Ala Ser Gly Gly Ala Ala Tyr Thr Lys Arg Tyr Leu Glu Glu Gln 

            340                 345                 350         





Lys Thr Glu Asn Gly Lys Asp Lys Glu Gln Lys Gln Thr Asn Thr Asp 

        355                 360                 365             





Lys Glu Lys Ile Lys Glu Lys Gly Ser Phe Ser Asp Thr Gly Leu Gly 

    370                 375                 380                 





Asp Gly Lys Met Lys Ser Asp Ser Phe Ala Pro Lys Thr Asp Ser Glu 

385                 390                 395                 400 





Lys Pro Phe Arg Gly Ser Gln Ser Pro Lys Arg Tyr Lys Leu Arg Asp 

                405                 410                 415     





Asp Phe Glu Lys Lys Met Ala Asp Phe His Lys Glu Glu Met Asp Asp 

            420                 425                 430         





Gln Asp Lys Asp Lys Ala Lys Gly Arg Lys Glu Ser Glu Phe Asp Asp 

        435                 440                 445             





Glu Pro Lys Phe Met Ser Lys Val Ile Gly Ala Asn Lys Asn Gln Glu 

    450                 455                 460                 





Glu Glu Lys Ser Gly Lys Trp Glu Gly Leu Val Tyr Ala Pro Pro Gly 

465                 470                 475                 480 





Lys Glu Lys Gln Arg Lys Thr Glu Glu Leu Glu Glu Glu Ser Phe Pro 

                485                 490                 495     





Glu Arg Ser Lys Lys Glu Asp Arg Gly Lys Arg Ser Glu Gly Gly His 

            500                 505                 510         





Arg Gly Phe Val Pro Glu Lys Asn Phe Arg Val Thr Ala Tyr Lys Ala 

        515                 520                 525             





Val Gln Glu Lys Ser Ser Ser Pro Pro Pro Arg Lys Thr Ser Glu Ser 

    530                 535                 540                 





Arg Asp Lys Leu Gly Ala Lys Gly Asp Phe Pro Thr Gly Lys Ser Ser 

545                 550                 555                 560 





Phe Ser Ile Thr Arg Glu Ala Gln Val Asn Val Arg Met Asp Ser Phe 

                565                 570                 575     





Asp Glu Asp Leu Ala Arg Pro Ser Gly Leu Leu Ala Gln Glu Arg Lys 

            580                 585                 590         





Leu Cys Arg Asp Leu Val His Ser Asn Lys Lys Glu Gln Glu Phe Arg 

        595                 600                 605             





Ser Ile Phe Gln His Ile Gln Ser Ala Gln Ser Gln Arg Ser Pro Ser 

    610                 615                 620                 





Glu Leu Phe Ala Gln His Ile Val Thr Ile Val His His Val Lys Glu 

625                 630                 635                 640 





His His Phe Gly Ser Ser Gly Met Thr Leu His Glu Arg Phe Thr Lys 

                645                 650                 655     





Tyr Leu Lys Arg Gly Thr Glu Gln Glu Ala Ala Lys Asn Lys Lys Ser 

            660                 665                 670         





Pro Glu Ile His Arg Arg Ile Asp Ile Ser Pro Ser Thr Phe Arg Lys 

        675                 680                 685             





His Gly Leu Ala His Asp Glu Met Lys Ser Pro Arg Glu Pro Gly Tyr 

    690                 695                 700                 





Lys Ala Glu Gly Lys Tyr Lys Asp Asp Pro Val Asp Leu Arg Leu Asp 

705                 710                 715                 720 





Ile Glu Arg Arg Lys Lys His Lys Glu Arg Asp Leu Lys Arg Gly Lys 

                725                 730                 735     





Ser Arg Glu Ser Val Asp Ser Arg Asp Ser Ser His Ser Arg Glu Arg 

            740                 745                 750         





Ser Ala Glu Lys Thr Glu Lys Thr His Lys Gly Ser Lys Lys Gln Lys 

        755                 760                 765             





Lys His Arg Arg Ala Arg Asp Arg Ser Arg Ser Ser Ser Ser Ser Ser 

    770                 775                 780                 





Gln Ser Ser His Ser Tyr Lys Ala Glu Glu Tyr Thr Glu Glu Thr Glu 

785                 790                 795                 800 





Glu Arg Glu Glu Ser Thr Thr Gly Phe Asp Lys Ser Arg Leu Gly Thr 

                805                 810                 815     





Lys Asp Phe Val Gly Pro Ser Glu Arg Gly Gly Gly Arg Ala Arg Gly 

            820                 825                 830         





Thr Phe Gln Phe Arg Ala Arg Gly Arg Gly Trp Gly Arg Gly Asn Tyr 

        835                 840                 845             





Ser Gly Asn Asn Asn Asn Asn Ser Asn Asn Asp Phe Gln Lys Arg Asn 

    850                 855                 860                 





Arg Glu Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr 

865                 870                 875                 880 





Tyr Leu His Asp Asp Arg Glu Gly Glu Gly Ser Asp Lys Trp Val Ser 

                885                 890                 895     





Arg Gly Arg Gly Arg Gly Ala Phe Pro Arg Gly Arg Gly Arg Phe Met 

            900                 905                 910         





Phe Arg Lys Ser Ser Thr Ser Pro Lys Trp Ala His Asp Lys Phe Ser 

        915                 920                 925             





Gly Glu Glu Gly Glu Ile Glu Asp Asp Glu Ser Gly Thr Glu Asn Arg 

    930                 935                 940                 





Glu Glu Lys Asp Asn Ile Gln Pro Thr Thr Glu 

945                 950                 955 





<210>  285

<211>  1011

<212>  DNA

<213>  Homo sapiens



<400>  285

ggcacaacag agccgctccc ctctcctcgc cccgccaccg ggacgagagg cgcccgccgc       60



tgcatttccg gcgacacctc gcagtcattc ctgcggcttg cgcgcccttg tagacagccg      120



gggccttcgt gagaccggtg caggcctggg gtagtctcct gtctggacag agaagagaaa      180



aatgcaggac actggctcag tagtgccttt gcattggttt ggctttggct acgcagcact      240



ggttgcttct ggtgggatca ttggctatgt aaaagcaggc agcgtgccgt ccctggctgc      300



agggctgctc tttggcagtc tagccggcct gggtgcttac cagctgtctc aggatccaag      360



gaacgtttgg gttttcctag ctacatctgg taccttggct ggcattatgg gaatgaggtt      420



ctaccactct ggaaaattca tgcctgcagg tttaattgca ggtgccagtt tgctgatggt      480



cgccaaagtt ggagttagta tgttcaacag accccattag cagaagtcat gttccagctt      540



agactgatga agaattaaaa atctgcatct tccactattt tcaatatatt aagagaaata      600



agtgcagcat ttttgcatct gacattttac ctaaaaaaaa agacaccaaa cttggcagag      660



aggtggaaaa tcagtcatga ttacaaacct acagaggtgg cgagtatgta acacaagagc      720



ttaataagac cctcatagag cttgattctt gtatattgat gttgtctttt ctttctgtat      780



ctgtaggtaa atctcaaggg taaaatgtta ggtgtcagct ttcagggctc tgaaacccta      840



ttccctgctc tgaggaacag tgtgaaaaaa agtcttttag gagatttaca atatctgttc      900



ttttgctcat cttagaccac agactgactt tgaaattatg ttaagtgaaa tatcaatgaa      960



aataaagttt actataaata ataaaaaaaa aaaaaaaaaa aaaaaaaaaa a              1011





<210>  286

<211>  112

<212>  PRT

<213>  Homo sapiens



<400>  286



Met Gln Asp Thr Gly Ser Val Val Pro Leu His Trp Phe Gly Phe Gly 

1               5                   10                  15      





Tyr Ala Ala Leu Val Ala Ser Gly Gly Ile Ile Gly Tyr Val Lys Ala 

            20                  25                  30          





Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu Ala 

        35                  40                  45              





Gly Leu Gly Ala Tyr Gln Leu Ser Gln Asp Pro Arg Asn Val Trp Val 

    50                  55                  60                  





Phe Leu Ala Thr Ser Gly Thr Leu Ala Gly Ile Met Gly Met Arg Phe 

65                  70                  75                  80  





Tyr His Ser Gly Lys Phe Met Pro Ala Gly Leu Ile Ala Gly Ala Ser 

                85                  90                  95      





Leu Leu Met Val Ala Lys Val Gly Val Ser Met Phe Asn Arg Pro His 

            100                 105                 110         





<210>  287

<211>  3687

<212>  DNA

<213>  Homo sapiens



<400>  287

gtttccgggc gggcctccag aggccggcgc acaagatggc ggctctggcg gcctaaagaa       60



ggcggccgcg gctcagccgt gggctctaac gcggggctgg gggccggaga cagacttcgc      120



ccaggtgacg ggtagtaggg gcggcgccgc ttggcctcgt ggggtgtaag acccacttgc      180



tgttgccccc ggaccttgcc gccacaccag ccctgtcctg gggcggaacc gaaggaaggt      240



cgggccctgc tgccccgccc cgtccttcct ccttcccggg cggtcactgt gcgtggctca      300



cttttagagt ttacttcaac cacgtggagc ttccatggcg gcctctcagg tcctggggga      360



gaagattaac atcctgtcgg gagagactgt caaagctggg gacagggacc cgctggggaa      420



cgactgtccc gagcaagata ggctccccca gcgctcctgg aggcagaagt gtgcctccta      480



cgtgttggcc ctgaggccct ggagcttcag tgcctcactc acaccggtgg ccctgggcag      540



tgcccttgcc tacagatccc acggtgtcct ggatcccagg ctcttggtgg gttgtgccgt      600



ggctgtcctg gctgtgcacg gggccggtaa tttggtcaac acttactatg acttttccaa      660



gggcattgac cacaaaaaga gtgatgacag gacacttgtg gaccgaatct tggagccgca      720



ggatgtcgtc cggttcggag tcttcctcta cacgttgggc tgcgtctgtg ccgcttgcct      780



ctactacctg tcccctctga aactggagca cttggctctt atctactttg gaggcctgtc      840



tggctccttt ctctacacag gaggaattgg attcaagtac gtggctctgg gagacctcat      900



catcctcatc acttttggcc cgctggctgt gatgttcgcc tacgccatcc aggtggggtc      960



cctggccatc ttcccactgg tctatgccat ccccctcgcc ctcagcaccg aggccattct     1020



ccattccaac aacaccaggg acatggagtc cgaccgggag gctggtatcg tcacgctggc     1080



catcctcatc ggccccacgt tctcctacat tctctacaac acactgctct tcctgcccta     1140



cctggtcttc agcatcctgg ccacacactg caccatcagc ctggcactcc ccctgcttac     1200



cattcccatg gccttctccc ttgagagaca gtttcgaagc caggccttca acaaactgcc     1260



ccagaggact gccaagctca acctcctgct gggacttttc tatgtctttg gcatcattct     1320



ggcaccagca ggcagtctgc ccaaaattta aggggacaag tagctccccc cacgacatgt     1380



ctccctttct tagaatatat taaagtcaga gtctctgagg aaggaatgtg atttggcagt     1440



cagggtacta agcatgggtg ggaactcctg ccttataaaa attgtttttg tgttcttaaa     1500



gataatatgt tgtttttctg ttttttgttt tttccatttt atggggaatt taaaaaccat     1560



tcttgtatca gaaggtgaat taggcgcatg gtctttgttt tattaataat ttccactaga     1620



gggtgttctc aggtcacttt gcagtgaagt ggacttagtt cctccttgtt ctgtacaaaa     1680



tgtctccaga ctttgtaaag gagctgccca gtttggcctc ctgtcccgaa aagaccctaa     1740



taactaggca gagtgttgtc ctgctttctt cgtctcgtag gatgtgctat gattggtgcc     1800



aggcctcact aacacagggg ctacctgtct cttattctca gcacctgtgt cctgagatac     1860



gctgcctgag acagagagag tccctcatta acagcctgtg tggctgtcag ctttttgcct     1920



aaattgtgat tcagatgctt ttgttctctc tcctttcact tattgccaca gttgaggaaa     1980



agtgtcagat taccctgcag caagacaagc caaggactgg gagggaaaaa aaaaccactc     2040



tggaggcaac tgagaaaatc actgcttttg gataggaatc agtagggtgg ctgttttccc     2100



tttgttgaat ctactagagt gacaggaagg actcccagcc ctttcagtaa ctatcaggag     2160



ccctgaaacg gtagaggcac tgccatcctt gtgggatact caaagcccac agggcttttc     2220



cctccctatt gcatcttctg atgctcccca cacctaccct ccacctctcc acctctgtgg     2280



tgttcccatt tgtgtgtttc ccatctgtgg agccagactg agcaatagct tagcagcgag     2340



tcagggacag ctgccacttt ccacagagcc acaggatggg cagagcaggg acccagggaa     2400



tgaatagcca gtggacaaac agtcttgagc tctgttcagc cagagtgatg ggccctgcca     2460



gttaaggggc tgtgtcttca tccttgaaga cagatgtgca atattgaccc tgcctctccc     2520



cagggctttg tggaaagata gttgagggct ttagtgagat cacactcaga gtggggcaat     2580



tccagcattt atcctggctg cgtttcattg cattgtctgt gaagtataat ttctgggcca     2640



gaattgctca gttgcatttg atccaggact atagattgga aatgggtcat cattgttttc     2700



tgttgtgatt atagccattc tagtaggcgt ttaaggtcat ggcctgcaga aaatgatgta     2760



agaactagtt cttaatcttt cagatcaagc taatgatgat atggaacctt gagttcgaat     2820



tgattggttt acttggaaaa aaacatgttt gaaaattgca aaagttccgc cgggcgcggt     2880



ggctcatgcc tgtaatccca gcactttggg aggccgagac gggcggatca cgaggtcagg     2940



agatcgagac catcttggct aacacggtga aaccccgttt ctactaaaaa tacaaaaaat     3000



tagccaggcg tgttggcggg cgcctgtagt cccagctacc tgggcggctg aggcaggagc     3060



atggcgtgaa cccaggaggc ggagcttgca gtgagctgag atcatgccac tgcactccaa     3120



cctgggggac acagcaagac tccgtctcaa aaaaaaaaaa agaaaaagaa aattgcaaaa     3180



gttcctctaa agttaaatca aaggtggttt gtctagcaga gagccagaat cttctaatag     3240



tgggcagagc ccagagacaa ggggaagaaa gatgaccttc tccccagtcc ttcccagcac     3300



catttttgtt tcacaccagg cttgtggcat tttggtgctc acaggggttt tgccttctga     3360



cctctccttg gagtaggcca ttctcatgca gggctcaccc tgaggcagga ggaccaaggg     3420



ctccctgcgt ccacggacca cgtatgcctt ggtggtcact cccatcgggg ctatcagttc     3480



tgcactgtgc cctggtgcgg attttaatgc atatttttat atataaatgt tcccaaaggc     3540



caaatttgtt gccaggtttt atacgcaggt caccataatt tgtattatgt tccctgagtc     3600



aatgaaggtt ttctttagac ttcttaatta aaaagagaag aaagaaaatg ttcaaaaaaa     3660



aaaaaaaaaa aaaaaaaaaa aaaaaaa                                         3687





<210>  288

<211>  338

<212>  PRT

<213>  Homo sapiens



<400>  288



Met Ala Ala Ser Gln Val Leu Gly Glu Lys Ile Asn Ile Leu Ser Gly 

1               5                   10                  15      





Glu Thr Val Lys Ala Gly Asp Arg Asp Pro Leu Gly Asn Asp Cys Pro 

            20                  25                  30          





Glu Gln Asp Arg Leu Pro Gln Arg Ser Trp Arg Gln Lys Cys Ala Ser 

        35                  40                  45              





Tyr Val Leu Ala Leu Arg Pro Trp Ser Phe Ser Ala Ser Leu Thr Pro 

    50                  55                  60                  





Val Ala Leu Gly Ser Ala Leu Ala Tyr Arg Ser His Gly Val Leu Asp 

65                  70                  75                  80  





Pro Arg Leu Leu Val Gly Cys Ala Val Ala Val Leu Ala Val His Gly 

                85                  90                  95      





Ala Gly Asn Leu Val Asn Thr Tyr Tyr Asp Phe Ser Lys Gly Ile Asp 

            100                 105                 110         





His Lys Lys Ser Asp Asp Arg Thr Leu Val Asp Arg Ile Leu Glu Pro 

        115                 120                 125             





Gln Asp Val Val Arg Phe Gly Val Phe Leu Tyr Thr Leu Gly Cys Val 

    130                 135                 140                 





Cys Ala Ala Cys Leu Tyr Tyr Leu Ser Pro Leu Lys Leu Glu His Leu 

145                 150                 155                 160 





Ala Leu Ile Tyr Phe Gly Gly Leu Ser Gly Ser Phe Leu Tyr Thr Gly 

                165                 170                 175     





Gly Ile Gly Phe Lys Tyr Val Ala Leu Gly Asp Leu Ile Ile Leu Ile 

            180                 185                 190         





Thr Phe Gly Pro Leu Ala Val Met Phe Ala Tyr Ala Ile Gln Val Gly 

        195                 200                 205             





Ser Leu Ala Ile Phe Pro Leu Val Tyr Ala Ile Pro Leu Ala Leu Ser 

    210                 215                 220                 





Thr Glu Ala Ile Leu His Ser Asn Asn Thr Arg Asp Met Glu Ser Asp 

225                 230                 235                 240 





Arg Glu Ala Gly Ile Val Thr Leu Ala Ile Leu Ile Gly Pro Thr Phe 

                245                 250                 255     





Ser Tyr Ile Leu Tyr Asn Thr Leu Leu Phe Leu Pro Tyr Leu Val Phe 

            260                 265                 270         





Ser Ile Leu Ala Thr His Cys Thr Ile Ser Leu Ala Leu Pro Leu Leu 

        275                 280                 285             





Thr Ile Pro Met Ala Phe Ser Leu Glu Arg Gln Phe Arg Ser Gln Ala 

    290                 295                 300                 





Phe Asn Lys Leu Pro Gln Arg Thr Ala Lys Leu Asn Leu Leu Leu Gly 

305                 310                 315                 320 





Leu Phe Tyr Val Phe Gly Ile Ile Leu Ala Pro Ala Gly Ser Leu Pro 

                325                 330                 335     





Lys Ile 

        





<210>  289

<211>  2628

<212>  DNA

<213>  Homo sapiens



<400>  289

gtgcgctgcc gtaccggtca cgtggacgtt tggtcacgtg actgcgtccg tggtcctccc       60



gtaggaaccg gcggactcgg ttggcgttgt ggggcagggg gtggtggagc aagatggcgg      120



ctcatctgtc ctacggccga gtgaacctaa acgtgttgcg cgaggcggtg cgtcgcgagc      180



tgcgcgagtt cctggacaag tgcgcaggaa gcaaggcaat agtttgggat gaatacctaa      240



ctggaccctt tggcctgatt gcacagtatt cactattgaa ggaacatgaa gtggaaaaaa      300



tgttcacact taaaggaaat cgtttgccgg cagctgatgt gaagaatata attttttttg      360



tcagacccag gctagagttg atggatataa tcgctgaaaa cgtgctcagt gaagatagac      420



gaggcccaac gagagatttt catattctgt ttgtgccacg ccgtagcctg ttgtgcgaac      480



agcggttgaa ggatctgggt gtcttgggat cctttattca cagggaggag tacagcttag      540



atctcattcc attcgatggg gatctcttat ccatggaatc agagggtgca ttcaaagagt      600



gctacctgga gggtgaccag acgagcctgt accacgcagc caaggggctg atgaccctgc      660



aagctctgta tggaacgatc ccccagatct ttgggaaagg agaatgcgct cggcaagtgg      720



ccaatatgat gatcaggatg aagagagagt ttacaggaag ccagaattca atatttcctg      780



tttttgataa tctcttgttg cttgatcgga atgtggattt attaacacct cttgccactc      840



agctgacata tgaaggactc attgatgaaa tttatggcat tcagaacagt tatgtgaaat      900



tacctccaga gaaatttgca cctaagaaac agggcgatgg tggtaaggac ctccccacgg      960



aagcaaagaa gctgcagctg aattctgcag aggagctcta tgctgagatc cgagataaga     1020



acttcaacgc agttggctct gtgctcagca agaaagcaaa gatcatctct gcagcattcg     1080



aggaaagaca caatgctaag accgtggggg agatcaagca gtttgtttcc cagttgcccc     1140



acatgcaggc agcaaggggc tcgcttgcaa accatacctc aattgcagaa ttgatcaaag     1200



atgtcactac ttctgaagac ttttttgata aattaaccgt ggaacaggag tttatgtctg     1260



gaatagacac tgataaggtc aacaattaca ttgaggattg tatcgcccaa aagcactcgt     1320



tgatcaaggt gttaagacta gtttgcctcc aatccgtgtg taatagtggg ctcaaacaaa     1380



aagttttgga ttattacaaa agagagattc tccagacata cggctatgag cacatattga     1440



ccttacacaa cctggagaag gccggcctgc tgaaaccgca gacggggggc agaaacaatt     1500



acccaactat acggaaaaca ttacgcctct ggatggatga tgttaatgag caaaacccca     1560



cggacatatc gtatgtgtac agtgggtatg ccccgctcag tgtgcggctg gcccagctgc     1620



tttcccggcc tggctggcgg agcatcgagg aggtcctccg catcctccca gggccccact     1680



ttgaggagcg gcagccactg cccacaggac tgcagaagaa acgtcaaccg ggagaaaacc     1740



gagtgactct gatatttttc cttgggggcg taaccttcgc tgaaattgct gccctgcgat     1800



ttctctccca gttggaagat ggaggtacag aatatgtcat tgccaccact aaactaatga     1860



atggaaccag ttggatagag gctctgatgg aaaaaccttt ctaggatgtt cagaggagac     1920



ttaacaagtg tactgcagaa taaactacct ctttgaagaa attgctgaaa ggaagtaaaa     1980



ccccatagaa gaaacatggg aatacagaat atattctggg gtcagcttct taaattatac     2040



tactgtttac tgctttctcc gtctcttttg tattcccttt ttttttttcc tttgagacgg     2100



agtcttgctc tgtcacccag actagagtgc agtggcacgg tctcacctca ctgcaacctc     2160



cacctcctag gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gactacaggc     2220



atgcaccacc acacccggct aatttttgta tttttagtag ccatggtgtt tcaccatgtt     2280



ggccaggctg gtctcaaact cctgacctca ggtgatccac ctgcctcggc ctcccacagt     2340



gctgggatta caggcctgag ccaccgtgcc tggcccctaa tctgctgaag aaagaagaat     2400



agaagaaaat caacctgagt aaaagcagca ctggttttga gttttctaag ctcagggtct     2460



tcattagaga cctctggaaa tacattaagg atggtggggg tagataatcc attcagccag     2520



acaaacgggg ccagctctta aaataagaaa gctgagactg aggaggtgaa actgaaaata     2580



aaaagagaaa gttcatcctc taaaaaaaaa aaaaaaaaaa aaaaaaaa                  2628





<210>  290

<211>  596

<212>  PRT

<213>  Homo sapiens



<400>  290



Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 

1               5                   10                  15      





Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 

            20                  25                  30          





Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 

        35                  40                  45              





Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 

    50                  55                  60                  





Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 

65                  70                  75                  80  





Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn 

                85                  90                  95      





Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 

            100                 105                 110         





Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 

        115                 120                 125             





Gly Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu 

    130                 135                 140                 





Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 

145                 150                 155                 160 





Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 

                165                 170                 175     





Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 

            180                 185                 190         





Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg 

        195                 200                 205             





Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe 

    210                 215                 220                 





Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 

225                 230                 235                 240 





Ala Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 

                245                 250                 255     





Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 

            260                 265                 270         





Gln Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln 

        275                 280                 285             





Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe 

    290                 295                 300                 





Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala 

305                 310                 315                 320 





Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln 

                325                 330                 335     





Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala 

            340                 345                 350         





Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu 

        355                 360                 365             





Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile 

    370                 375                 380                 





Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys 

385                 390                 395                 400 





His Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys 

                405                 410                 415     





Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile 

            420                 425                 430         





Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu 

        435                 440                 445             





Lys Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro 

    450                 455                 460                 





Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln 

465                 470                 475                 480 





Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser 

                485                 490                 495     





Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu 

            500                 505                 510         





Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro 

        515                 520                 525             





Leu Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val 

    530                 535                 540                 





Thr Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala 

545                 550                 555                 560 





Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile 

                565                 570                 575     





Ala Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met 

            580                 585                 590         





Glu Lys Pro Phe 

        595     





<210>  291

<211>  3003

<212>  DNA

<213>  Homo sapiens



<400>  291

ctttctcctt ccccttcttc cgggctcccg tcccggctca tcacccggcc tgtggcccac       60



tcccaccgcc agctggaacc ctggggacta cgacgtccct caaaccttgc ttctaggaga      120



taaaaagaac atccagtcat ggataaaaat gagctggttc agaaggccaa actggccgag      180



caggctgagc gatatgatga catggcagcc tgcatgaagt ctgtaactga gcaaggagct      240



gaattatcca atgaggagag gaatcttctc tcagttgctt ataaaaatgt tgtaggagcc      300



cgtaggtcat cttggagggt cgtctcaagt attgaacaaa agacggaagg tgctgagaaa      360



aaacagcaga tggctcgaga atacagagag aaaattgaga cggagctaag agatatctgc      420



aatgatgtac tgtctctttt ggaaaagttc ttgatcccca atgcttcaca agcagagagc      480



aaagtcttct atttgaaaat gaaaggagat tactaccgtt acttggctga ggttgccgct      540



ggtgatgaca agaaagggat tgtcgatcag tcacaacaag cataccaaga agcttttgaa      600



atcagcaaaa aggaaatgca accaacacat cctatcagac tgggtctggc ccttaacttc      660



tctgtgttct attatgagat tctgaactcc ccagagaaag cctgctctct tgcaaagaca      720



gcttttgatg aagccattgc tgaacttgat acattaagtg aagagtcata caaagacagc      780



acgctaataa tgcaattact gagagacaac ttgacattgt ggacatcgga tacccaagga      840



gacgaagctg aagcaggaga aggaggggaa aattaaccgg ccttccaact tttgtctgcc      900



tcattctaaa atttacacag tagaccattt gtcatccatg ctgtcccaca aatagttttt      960



tgtttacgat ttatgacagg tttatgttac ttctatttga atttctatat ttcccatgtg     1020



gtttttatgt ttaatattag gggagtagag ccagttaaca tttagggagt tatctgtttt     1080



catcttgagg tggccaatat ggggatgtgg aatttttata caagttataa gtgtttggca     1140



tagtactttt ggtacattgt ggcttcaaaa gggccagtgt aaaactgctt ccatgtctaa     1200



gcaaagaaaa ctgcctacat actggtttgt cctggcgggg aataaaaggg atcattggtt     1260



ccagtcacag gtgtagtaat tgtgggtact ttaaggtttg gagcacttac aaggctgtgg     1320



tagaatcata ccccatggat accacatatt aaaccatgta tatctgtgga atactcaatg     1380



tgtacacctt tgactacagc tgcagaagtg ttcctttaga caaagttgtg acccatttta     1440



ctctggataa gggcagaaac ggttcacatt ccattatttg taaagttacc tgctgttagc     1500



tttcattatt tttgctacac tcattttatt tgtatttaaa tgttttaggc aacctaagaa     1560



caaatgtaaa agtaaagatg caggaaaaat gaattgcttg gtattcatta cttcatgtat     1620



atcaagcaca gcagtaaaac aaaaacccat gtatttaact tttttttagg atttttgctt     1680



ttgtgatttt tttttttttg atacttgcct aacatgcatg tgctgtaaaa atagttaaca     1740



gggaaataac ttgagatgat ggctagcttt gtttaatgtc ttatgaaatt ttcatgaaca     1800



atccaagcat aattgttaag aacacgtgta ttaaattcat gtaagtggaa taaaagtttt     1860



atgaatggac ttttcaacta ctttctctac agcttttcat gtaaattagt cttggttctg     1920



aaacttctct aaaggaaatt gtacattttt tgaaatttat tccttattcc ctcttggcag     1980



ctaatgggct cttaccaagt ttaaacacaa aatttatcat aacaaaaata ctactaatat     2040



aactactgtt tccatgtccc atgatcccct ctcttcctcc ccaccctgaa aaaaatgagt     2100



tcctattttt tctgggagag ggggggattg attagaaaaa aatgtagtgt gttccattta     2160



aaattttggc atatggcatt ttctaactta ggaagccaca atgttcttgg cccatcatga     2220



cattgggtag cattaactgt aagttttgtg cttccaaatc actttttggt ttttaagaat     2280



ttcttgatac tcttatagcc tgccttcaat tttgatcctt tattctttct atttgtcagg     2340



tgcacaagat taccttcctg ttttagcctt ctgtcttgtc accaaccatt cttacttggt     2400



ggccatgtac ttggaaaaag gccgcatgat ctttctggct ccactcagtg tctaaggcac     2460



cctgcttcct ttgcttgcat cccacagact atttccctca tcctatttac tgcagcaaat     2520



ctctccttag ttgatgagac tgtgtttatc tccctttaaa accctaccta tcctgaatgg     2580



tctgtcattg tctgccttta aaatccttcc tctttcttcc tcctctattc tctaaataat     2640



gatggggcta agttataccc aaagctcact ttacaaaata tttcctcagt actttgcaga     2700



aaacaccaaa caaaaatgcc attttaaaaa aggtgtattt tttcttttag aatgtaagct     2760



cctcaagagc agggacaatg ttttctgtat gttctattgt gcctagtaca ctgtaaatgc     2820



tcaataaata ttgatgatgg gaggcagtga gtcttgatga taagggtgag aaactgaaat     2880



cccaaacact gttttgttgc ttgttttatt atgacctcag attaaattgg gaaatattgg     2940



cccttttgaa taattgtccc aaatattaca ttcaaataaa agtgcaatgg agaaaaaaaa     3000



aaa                                                                   3003





<210>  292

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  292



Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 

1               5                   10                  15      





Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 

            20                  25                  30          





Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 

        35                  40                  45              





Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 

    50                  55                  60                  





Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 

65                  70                  75                  80  





Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 

                85                  90                  95      





Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 

            100                 105                 110         





Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 

        115                 120                 125             





Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 

    130                 135                 140                 





Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 

145                 150                 155                 160 





Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 

                165                 170                 175     





Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 

            180                 185                 190         





Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 

        195                 200                 205             





Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 

    210                 215                 220                 





Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 

225                 230                 235                 240 





Glu Gly Gly Glu Asn 

                245 





<210>  293

<211>  3077

<212>  DNA

<213>  Homo sapiens



<400>  293

gcagcgtttg acgtcatcgt gcgtgtggtg cccctgctgc cggggctggt gattggagga       60



aaccccgtgt ctgcggagcg gctgtagcct gtgagcagcg agatccaggg acagagtctc      120



agcctcgccg ctgctgccgc cgccgccgcc cagagactgc tgagcccgtc cgtccgccgc      180



caccacccac tccggacaca gaacatccag tcatggataa aaatgagctg gttcagaagg      240



ccaaactggc cgagcaggct gagcgatatg atgacatggc agcctgcatg aagtctgtaa      300



ctgagcaagg agctgaatta tccaatgagg agaggaatct tctctcagtt gcttataaaa      360



atgttgtagg agcccgtagg tcatcttgga gggtcgtctc aagtattgaa caaaagacgg      420



aaggtgctga gaaaaaacag cagatggctc gagaatacag agagaaaatt gagacggagc      480



taagagatat ctgcaatgat gtactgtctc ttttggaaaa gttcttgatc cccaatgctt      540



cacaagcaga gagcaaagtc ttctatttga aaatgaaagg agattactac cgttacttgg      600



ctgaggttgc cgctggtgat gacaagaaag ggattgtcga tcagtcacaa caagcatacc      660



aagaagcttt tgaaatcagc aaaaaggaaa tgcaaccaac acatcctatc agactgggtc      720



tggcccttaa cttctctgtg ttctattatg agattctgaa ctccccagag aaagcctgct      780



ctcttgcaaa gacagctttt gatgaagcca ttgctgaact tgatacatta agtgaagagt      840



catacaaaga cagcacgcta ataatgcaat tactgagaga caacttgaca ttgtggacat      900



cggataccca aggagacgaa gctgaagcag gagaaggagg ggaaaattaa ccggccttcc      960



aacttttgtc tgcctcattc taaaatttac acagtagacc atttgtcatc catgctgtcc     1020



cacaaatagt tttttgttta cgatttatga caggtttatg ttacttctat ttgaatttct     1080



atatttccca tgtggttttt atgtttaata ttaggggagt agagccagtt aacatttagg     1140



gagttatctg ttttcatctt gaggtggcca atatggggat gtggaatttt tatacaagtt     1200



ataagtgttt ggcatagtac ttttggtaca ttgtggcttc aaaagggcca gtgtaaaact     1260



gcttccatgt ctaagcaaag aaaactgcct acatactggt ttgtcctggc ggggaataaa     1320



agggatcatt ggttccagtc acaggtgtag taattgtggg tactttaagg tttggagcac     1380



ttacaaggct gtggtagaat cataccccat ggataccaca tattaaacca tgtatatctg     1440



tggaatactc aatgtgtaca cctttgacta cagctgcaga agtgttcctt tagacaaagt     1500



tgtgacccat tttactctgg ataagggcag aaacggttca cattccatta tttgtaaagt     1560



tacctgctgt tagctttcat tatttttgct acactcattt tatttgtatt taaatgtttt     1620



aggcaaccta agaacaaatg taaaagtaaa gatgcaggaa aaatgaattg cttggtattc     1680



attacttcat gtatatcaag cacagcagta aaacaaaaac ccatgtattt aacttttttt     1740



taggattttt gcttttgtga tttttttttt tttgatactt gcctaacatg catgtgctgt     1800



aaaaatagtt aacagggaaa taacttgaga tgatggctag ctttgtttaa tgtcttatga     1860



aattttcatg aacaatccaa gcataattgt taagaacacg tgtattaaat tcatgtaagt     1920



ggaataaaag ttttatgaat ggacttttca actactttct ctacagcttt tcatgtaaat     1980



tagtcttggt tctgaaactt ctctaaagga aattgtacat tttttgaaat ttattcctta     2040



ttccctcttg gcagctaatg ggctcttacc aagtttaaac acaaaattta tcataacaaa     2100



aatactacta atataactac tgtttccatg tcccatgatc ccctctcttc ctccccaccc     2160



tgaaaaaaat gagttcctat tttttctggg agaggggggg attgattaga aaaaaatgta     2220



gtgtgttcca tttaaaattt tggcatatgg cattttctaa cttaggaagc cacaatgttc     2280



ttggcccatc atgacattgg gtagcattaa ctgtaagttt tgtgcttcca aatcactttt     2340



tggtttttaa gaatttcttg atactcttat agcctgcctt caattttgat cctttattct     2400



ttctatttgt caggtgcaca agattacctt cctgttttag ccttctgtct tgtcaccaac     2460



cattcttact tggtggccat gtacttggaa aaaggccgca tgatctttct ggctccactc     2520



agtgtctaag gcaccctgct tcctttgctt gcatcccaca gactatttcc ctcatcctat     2580



ttactgcagc aaatctctcc ttagttgatg agactgtgtt tatctccctt taaaacccta     2640



cctatcctga atggtctgtc attgtctgcc tttaaaatcc ttcctctttc ttcctcctct     2700



attctctaaa taatgatggg gctaagttat acccaaagct cactttacaa aatatttcct     2760



cagtactttg cagaaaacac caaacaaaaa tgccatttta aaaaaggtgt attttttctt     2820



ttagaatgta agctcctcaa gagcagggac aatgttttct gtatgttcta ttgtgcctag     2880



tacactgtaa atgctcaata aatattgatg atgggaggca gtgagtcttg atgataaggg     2940



tgagaaactg aaatcccaaa cactgttttg ttgcttgttt tattatgacc tcagattaaa     3000



ttgggaaata ttggcccttt tgaataattg tcccaaatat tacattcaaa taaaagtgca     3060



atggagaaaa aaaaaaa                                                    3077





<210>  294

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  294



Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 

1               5                   10                  15      





Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 

            20                  25                  30          





Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 

        35                  40                  45              





Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 

    50                  55                  60                  





Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 

65                  70                  75                  80  





Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 

                85                  90                  95      





Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 

            100                 105                 110         





Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 

        115                 120                 125             





Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 

    130                 135                 140                 





Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 

145                 150                 155                 160 





Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 

                165                 170                 175     





Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 

            180                 185                 190         





Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 

        195                 200                 205             





Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 

    210                 215                 220                 





Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 

225                 230                 235                 240 





Glu Gly Gly Glu Asn 

                245 





<210>  295

<211>  2121

<212>  DNA

<213>  Homo sapiens



<400>  295

gatcgggtag gcggctcttt gtcgaagcta gaggaccggc aggcggcagc agcaactacg       60



gcggcggcgg cagaacccag cagcgatgtg gaggtggaga cccacaggag ccccggactt      120



cacctgagct acctcagtgg tcaccaagag tggcaagata aagaaaaccc tgagttgggc      180



gggaccagga tgcctgaccg ggacagctat gccaacggta ccgggagcag cggtggaggc      240



cctggaggtg gtggcagcga ggaggccagt ggggcagggg taggcagtgg cggggccagc      300



tcagatgcca tctgtagaga cttcttgagg aatgtgtgca agcgaggcaa gcgttgccga      360



tatcgccacc cagacatgag cgaggtgtcc aacttggggg tgagcaaaaa cgagttcatc      420



ttctgccatg acttccagaa caaggagtgt agccgcccaa attgccgttt catccatggc      480



tccaaggagg atgaggatgg ctataagaag acaggagagc ttcccccacg gctgaggcag      540



aaagtagcag ctggccttgg cctttcaccg gctgacctac caaatggcaa ggaggaggtc      600



cctatctgcc gtgactttct caagggtgac tgtcagagag gagccaagtg caagttccgt      660



cacctgcaac gggattttga gtttgatgct cggggtggag gaggcactgg tgggggctca      720



acaggctcag tcctcccagg acgacgtcat gatctctatg atatctatga ccttcctgac      780



aggggctttg aggaccatga gccaggccca aaacgccggc gaggtggatg ctgcccccct      840



gatggccctc attttgagtc atatgaatat agtttggctc caccgcgagg ggtggagtgc      900



agactgctag aggaggagaa tgccatgctc aggaagcggg tagaggagtt aaagaagcag      960



gtcagcaacc tgctggccac caatgaggta ctactggaac aaaatgctca gttccgcaat     1020



caggccaagg tcataaccct gagctccact gcaccagcga ctgagcagac tctggccccc     1080



actgtgggca ctgttgccac ttttaaccat ggcattgccc agactcacac tactctcagc     1140



agccaggctc tacagcctcg tccagtgtcc cagcaagaac tggtggcccc tgctggagct     1200



ccagctgctc ccccaactaa tgctgcacct cctgctgctc cgccaccccc acccccacac     1260



ttgaccccag agatcacgcc actgtcagct gccctggctc aaacaattgc ccagggaatg     1320



gcacctccac ctgtctccat ggctcctgtg gctgtatctg tggctcctgt ggcccctgtg     1380



gctgtatcga tggcccaacc cttggcagga atcacaatga gccacaccac cactcccatg     1440



gtgacttacc ctatcgcttc ccagagcatg cgcatcacgg ccatgccaca ctgatggggc     1500



taatggacac tcccctggta tagcctcgca gggctggggt cagggggccc ttgcccactc     1560



acctagcctt ccccatccct gtctgaaggg ctcccttgag aactaggaca agagactaca     1620



aggagtatgt cctgaggagg ggttgggatg gtgtgttttc tctcacctcc cttttatgag     1680



ggtcctcttg tccatcttca agcctcacag tgggggcttg cagaggagtg cagactgaag     1740



ccagcagaga ggaaggactg actgaggggc tgtgtcctct tatgggaatt tgggaacatc     1800



cctcgtcttg tcctctcttc tgcacagcac aggttccagc actggtttta gaagaaaaaa     1860



ataccctgcc cagagggaaa gccaggaaag attgggaagt gggtggtcag gagagaaggc     1920



ctgataggag ccttcagaca atttgggtcc tagttgcttg ggttggacaa tacaggaatt     1980



gcttctgggc cctgggaaag ctgggaccat agtgctccag cccaaagact aggggagcat     2040



tcattaccct agtttgacct gaaaatccat agggcagggc ccactacttt ccaaagaaat     2100



aaaagaacaa ttatttttaa c                                               2121





<210>  296

<211>  434

<212>  PRT

<213>  Homo sapiens



<400>  296



Met Pro Asp Arg Asp Ser Tyr Ala Asn Gly Thr Gly Ser Ser Gly Gly 

1               5                   10                  15      





Gly Pro Gly Gly Gly Gly Ser Glu Glu Ala Ser Gly Ala Gly Val Gly 

            20                  25                  30          





Ser Gly Gly Ala Ser Ser Asp Ala Ile Cys Arg Asp Phe Leu Arg Asn 

        35                  40                  45              





Val Cys Lys Arg Gly Lys Arg Cys Arg Tyr Arg His Pro Asp Met Ser 

    50                  55                  60                  





Glu Val Ser Asn Leu Gly Val Ser Lys Asn Glu Phe Ile Phe Cys His 

65                  70                  75                  80  





Asp Phe Gln Asn Lys Glu Cys Ser Arg Pro Asn Cys Arg Phe Ile His 

                85                  90                  95      





Gly Ser Lys Glu Asp Glu Asp Gly Tyr Lys Lys Thr Gly Glu Leu Pro 

            100                 105                 110         





Pro Arg Leu Arg Gln Lys Val Ala Ala Gly Leu Gly Leu Ser Pro Ala 

        115                 120                 125             





Asp Leu Pro Asn Gly Lys Glu Glu Val Pro Ile Cys Arg Asp Phe Leu 

    130                 135                 140                 





Lys Gly Asp Cys Gln Arg Gly Ala Lys Cys Lys Phe Arg His Leu Gln 

145                 150                 155                 160 





Arg Asp Phe Glu Phe Asp Ala Arg Gly Gly Gly Gly Thr Gly Gly Gly 

                165                 170                 175     





Ser Thr Gly Ser Val Leu Pro Gly Arg Arg His Asp Leu Tyr Asp Ile 

            180                 185                 190         





Tyr Asp Leu Pro Asp Arg Gly Phe Glu Asp His Glu Pro Gly Pro Lys 

        195                 200                 205             





Arg Arg Arg Gly Gly Cys Cys Pro Pro Asp Gly Pro His Phe Glu Ser 

    210                 215                 220                 





Tyr Glu Tyr Ser Leu Ala Pro Pro Arg Gly Val Glu Cys Arg Leu Leu 

225                 230                 235                 240 





Glu Glu Glu Asn Ala Met Leu Arg Lys Arg Val Glu Glu Leu Lys Lys 

                245                 250                 255     





Gln Val Ser Asn Leu Leu Ala Thr Asn Glu Val Leu Leu Glu Gln Asn 

            260                 265                 270         





Ala Gln Phe Arg Asn Gln Ala Lys Val Ile Thr Leu Ser Ser Thr Ala 

        275                 280                 285             





Pro Ala Thr Glu Gln Thr Leu Ala Pro Thr Val Gly Thr Val Ala Thr 

    290                 295                 300                 





Phe Asn His Gly Ile Ala Gln Thr His Thr Thr Leu Ser Ser Gln Ala 

305                 310                 315                 320 





Leu Gln Pro Arg Pro Val Ser Gln Gln Glu Leu Val Ala Pro Ala Gly 

                325                 330                 335     





Ala Pro Ala Ala Pro Pro Thr Asn Ala Ala Pro Pro Ala Ala Pro Pro 

            340                 345                 350         





Pro Pro Pro Pro His Leu Thr Pro Glu Ile Thr Pro Leu Ser Ala Ala 

        355                 360                 365             





Leu Ala Gln Thr Ile Ala Gln Gly Met Ala Pro Pro Pro Val Ser Met 

    370                 375                 380                 





Ala Pro Val Ala Val Ser Val Ala Pro Val Ala Pro Val Ala Val Ser 

385                 390                 395                 400 





Met Ala Gln Pro Leu Ala Gly Ile Thr Met Ser His Thr Thr Thr Pro 

                405                 410                 415     





Met Val Thr Tyr Pro Ile Ala Ser Gln Ser Met Arg Ile Thr Ala Met 

            420                 425                 430         





Pro His 

        





<210>  297

<211>  5811

<212>  DNA

<213>  Homo sapiens



<400>  297

gtccgtccgg ttcttgctat attgccccag gctggtctcg aactcctggg ctcaagccgt       60



tctcccgcct cccactgccc gcctgtcact gccgtctgtt ccctgagctg tgctttacgc      120



tgggaaagac atagaagaac tattaagaag atagaattgt tttgctgcgc agtacagcaa      180



cagtggatgt tcaagattaa gattagagtc aagttgtgtg attaagacag gagctgtgac      240



tgatgagaat taaaggccat ggatgaagat gggcttgaat tacaacaaga gccaaactca      300



ttttttgatg caacaggagc tgatggtaca cacatggatg gtgatcaaat tgttgtggaa      360



gtacaagaaa ctgtttttgt ttcagatgtt gtggattcag acataactgt gcataacttt      420



gttcctgatg acccagattc agttgtaatc caagatgtta ttgaggacgt tgttatagaa      480



gatgttcagt gcccagatat catggaagaa gcagatgtgt ctgaaacggt catcattcct      540



gagcaagtgc tggactcaga tgtaactgaa gaagtttctt tagcacattg cacagtccca      600



gatgatgttt tagcttctga cattacttca gcctcaatgt ctatgccaga acacgtcttg      660



acgggtgatt ctatacatgt gtctgacgtt ggacatgttg gacatgttgg acatgttgaa      720



catgtggttc atgatagtgt agtggaagca gaaattgtca ctgatcctct gactaccgac      780



gtagtttcag aagaagtatt ggtagcagac tgtgcctctg aagcagtcat agatgccaat      840



gggatccctg tggaccagca ggatgatgac aaaggcaact gtgaggacta ccttatgatt      900



tccttggatg atgctggcaa aatagaacac gatggttctt ctggaatgac catggacaca      960



gagtcggaaa ttgatccttg taaagtggat ggcacttgcc ctgaggtcat caaggtgtac     1020



atttttaaag ctgaccctgg agaagatgac ttaggtggaa ctgtagacat tgtggagagt     1080



gagcctgaga atgatcatgg agttgaactg cttgatcaga acagcagtat tcgtgttccc     1140



agggaaaaga tggtttatat gactgtcaat gactctcagc cagaagatga agatttaaat     1200



gttgctgaaa tcgctgacga agtttatatg gaagtgatcg taggagagga ggatgctgca     1260



gcagcagcgg cagccgccgc cgtgcacgag cagcaaatgg atgacaatga aatcaaaacc     1320



ttcatgccga ttgcatgggc agcagcttat ggtaataatt ctgatggaat tgaaaaccgg     1380



aatggcactg caagtgccct cttgcacata gatgagtctg ctggcctcgg cagactggct     1440



aaacaaaaac caaagaaaag gagaagacct gattccaggc agtaccaaac agcaataatt     1500



attggccctg atggacatcc tttgactgtc tatccttgca tgatttgtgg gaagaagttt     1560



aagtcgagag gttttttgaa aaggcacatg aaaaaccatc ccgaacacct tgccaagaag     1620



aaataccgct gtactgactg tgattacact accaacaaga agataagttt acacaaccac     1680



ctggagagcc acaagctgac cagcaaggca gagaaggcca ttgaatgcga tgagtgtggg     1740



aagcatttct ctcatgcagg ggctttgttt actcacaaaa tggtgcataa ggaaaaagga     1800



gccaacaaaa tgcacaagtg taaattctgt gaatacgaga cagctgaaca agggttattg     1860



aatcgccacc tcttggcagt ccacagcaag aactttcctc atatttgtgt ggagtgtggt     1920



aagggttttc gtcacccgtc agagctcaaa aagcacatga gaatccatac tggggagaag     1980



ccgtaccaat gccagtactg cgaatatagg tctgcagact cttctaactt gaaaacgcat     2040



gtcaaaacta agcatagtaa agagatgcca ttcaagtgtg acatttgtct tctgactttc     2100



tcggatacca aagaggtgca gcaacatgct cttatccacc aagaaagcaa aacacaccag     2160



tgtttgcatt gcgaccacaa gagttcgaac tcaagtgatt tgaaacgaca cataatttca     2220



gttcacacga aagactaccc ccataagtgt gacatgtgtg ataaaggctt tcacaggcct     2280



tcagaactca agaaacacgt ggctgcccac aagggcaaaa aaatgcacca gtgtagacat     2340



tgtgacttta agattgcaga tccatttgtt ctaagtcgcc atattctctc agttcacaca     2400



aaggatcttc catttaggtg caagagatgt agaaagggat ttaggcaaca gagtgagctt     2460



aaaaagcata tgaagacaca cagtggcagg aaagtgtatc agtgtgagta ctgtgagtat     2520



agcactacag atgcctcagg ctttaaacgg cacgttattt ccattcacac gaaagactat     2580



cctcaccggt gtgagtactg caagaaaggc ttccgaagac cttcagaaaa gaaccagcac     2640



ataatgcgac atcataaaga agttggcctg ccctaacaat acttctacag aacgtttgta     2700



gagatattgg ccttgaagca gaaaattcat tttaaagcca atcagtctca ttcacataca     2760



atactgtata ttgatttatg ctgtgtacaa atagaattat tacttctagt tgactttttt     2820



ttaaatatac attttgctca gtagtgtgtt ctgaattcta ttcagtttgt ttaataaata     2880



gggaaaactg gcaacatgct agttactttt aataaagtaa tccctgattc tataccgaag     2940



ttttatatct tagaatttta tatttattta aatatttacc ttgcttacct tgatggtact     3000



cttctaagac cattaactta aggtaacttt atattggtaa ctctgaaagt attcatgttg     3060



actcattttt ttccccatac atttctcaca ataaaattgt cagagacatc tactaatata     3120



aatgggagat tttacagtca ggtctaatta tcataacatg gaagtcattt acttgtcttg     3180



cttaatattt tcagaccact tgacagtgaa agtttccatt tgagctgttg cgtccctggc     3240



tttgctgagt aaagagcagt ggctgggttc gtgtttactt ttcaaatata cttcttttgg     3300



ctttctttgg attatttaca tcttttgtca gcgtagcaaa cttttagaaa accttattga     3360



aaaactgtgc ttgctcatgt tgtattttga ttattctgtc tgtgcggctt catcttggaa     3420



tggttgtgtg ctacaaatga cacttactga ggactgcatt ttggaatctc ctagaggtaa     3480



ctcatggctt ataggatctt ttgcaacttt atgtatgtaa atgtaccctg aattatatat     3540



atacacatat atatcatgta cctgtgtgta ttgcttattt tacatattta tacacacaac     3600



cccaagtagt agttgtttaa aatctataat gaaaagtatt aaatttacaa taacatgaaa     3660



gatccaggga tgcatgagag agcattttgt aagtcatgct cttcagagag actactcagg     3720



tgaagaatta gaaggaaaat aaggacacta gtatttttaa agagtaaaga tattttcttt     3780



taaatatctt tggtaattga aacatagagg ttaagatgtt tctaggtaga atgttttcat     3840



acaatttcac ctccatgtct ttatgttttt ctgaaaagca aatgagtatc cagacatgac     3900



tcccacagtt ctctttgaga agcctgagag ggaactctgt cttacctagt gagggggatg     3960



gaaaagaagt gatggctctg tggaccagag aacgggtgct aattatgact tcacactcgg     4020



caagttcagg ctgatctgtt atttctcagt tacagttagc aaactttaaa aacttaacac     4080



tcaagttggc tttgattaaa aggtaaagat gtgttttaag tggataagga aagtctgagg     4140



ccttatttgg aacatcacta agtcttccac aggttttttg tttgtttgtt tttttttgtt     4200



gttttttttt cttaagacgg agtcttgctc tgttgcccag gctggactgc agtggtgtga     4260



tcactgcaac ctctgcagct cactgcaacc tctgcttcct gggttcaagc aattatctgc     4320



ctcagcctct cgagtagctg ggattacagg cgcccaccac cacgcccggc taattttttg     4380



tatttttaat agagatgggg tttcaccatc ttggccaggc tggtcttgaa ccctgacctc     4440



gtgatccacc tgcctcggcc ttccatagtg ctgggtttac aggcgtgagc caccgtgccc     4500



agacaccaca taggtctgaa tcagtgtcat acattcataa aacaaactcg gttaattaga     4560



acttggttat gttaagacga atctgggaga acagaaaaca gtttttgggg tcccttcagt     4620



tggctattgg tccgtatgca tctagcacat tgtaggagat ttagaaattg tcttcccacc     4680



cgatagctgc cttgtcacct cattatggtg ctccatcccc tgtgtgctta ggtttttacc     4740



tttcatcttt ctctttgcca ttgatgtttg tattcaagag ttatattttt agggttagaa     4800



atcaaaatat ttggtgtttg gcaaacctct gaagtgctag actgatttag tctagtttta     4860



aaccaagtgc tttaggcagg tgtgaactcc agcccaaatg ccagtcaaag tcaaggcatg     4920



ggttttccta gcctatctta taggaaattc ctgtaccttc ttggccccca taatgtgttt     4980



tttttttttt ttttttttta aactaactta caattttgtg atccgtgatt cattgccctg     5040



cgattcttga aagctctgtc tgtttttttg tgagaacctt taaaatctcc cttaattttt     5100



attttcccag aaataatgta aaaacactta aatgaaagtg gaaatgtatt aattttaaat     5160



cctataaaat taatacagaa aatataaatg attgggtcat ttaactatat ttttttaaat     5220



aaactgaaag ataaagaaca caacacttca cacattttat atttctctta catactccgg     5280



aatcatacac agttcttttt aaagcacaac attaaaacct ttaaaaggta tttaagggtt     5340



tggtcaagtg aatatgataa aacatacttg tctgtataaa gagaaaatga aattgtagtc     5400



actgttatgt actgacatta gttacaacct agttttaatt cttaaaacaa ttttgattag     5460



caaagctaaa aaaaaatgga tgtttcagtt aaatgtttta aagaggtaca gatttttaca     5520



aggacataat ataagttatt gttctgtaga aatatcctat taaatattgt atgtccctcc     5580



ctctgtacac tttgtaaaga aagtaaaata cataaaaaga aaatcatata gggatgtgtg     5640



acattattgt aattgtgtac ttgagaataa cgtgcaaaaa taaaaatcag aatattttcc     5700



tgttattgaa tgtttagtct atttgatacc agtactaagt taatgctttt tctcaaggaa     5760



aaaaaatgta cagtttttgt aaacctaata aacatcaaaa gcagtggatt a              5811





<210>  298

<211>  805

<212>  PRT

<213>  Homo sapiens



<400>  298



Met Asp Glu Asp Gly Leu Glu Leu Gln Gln Glu Pro Asn Ser Phe Phe 

1               5                   10                  15      





Asp Ala Thr Gly Ala Asp Gly Thr His Met Asp Gly Asp Gln Ile Val 

            20                  25                  30          





Val Glu Val Gln Glu Thr Val Phe Val Ser Asp Val Val Asp Ser Asp 

        35                  40                  45              





Ile Thr Val His Asn Phe Val Pro Asp Asp Pro Asp Ser Val Val Ile 

    50                  55                  60                  





Gln Asp Val Ile Glu Asp Val Val Ile Glu Asp Val Gln Cys Pro Asp 

65                  70                  75                  80  





Ile Met Glu Glu Ala Asp Val Ser Glu Thr Val Ile Ile Pro Glu Gln 

                85                  90                  95      





Val Leu Asp Ser Asp Val Thr Glu Glu Val Ser Leu Ala His Cys Thr 

            100                 105                 110         





Val Pro Asp Asp Val Leu Ala Ser Asp Ile Thr Ser Ala Ser Met Ser 

        115                 120                 125             





Met Pro Glu His Val Leu Thr Gly Asp Ser Ile His Val Ser Asp Val 

    130                 135                 140                 





Gly His Val Gly His Val Gly His Val Glu His Val Val His Asp Ser 

145                 150                 155                 160 





Val Val Glu Ala Glu Ile Val Thr Asp Pro Leu Thr Thr Asp Val Val 

                165                 170                 175     





Ser Glu Glu Val Leu Val Ala Asp Cys Ala Ser Glu Ala Val Ile Asp 

            180                 185                 190         





Ala Asn Gly Ile Pro Val Asp Gln Gln Asp Asp Asp Lys Gly Asn Cys 

        195                 200                 205             





Glu Asp Tyr Leu Met Ile Ser Leu Asp Asp Ala Gly Lys Ile Glu His 

    210                 215                 220                 





Asp Gly Ser Ser Gly Met Thr Met Asp Thr Glu Ser Glu Ile Asp Pro 

225                 230                 235                 240 





Cys Lys Val Asp Gly Thr Cys Pro Glu Val Ile Lys Val Tyr Ile Phe 

                245                 250                 255     





Lys Ala Asp Pro Gly Glu Asp Asp Leu Gly Gly Thr Val Asp Ile Val 

            260                 265                 270         





Glu Ser Glu Pro Glu Asn Asp His Gly Val Glu Leu Leu Asp Gln Asn 

        275                 280                 285             





Ser Ser Ile Arg Val Pro Arg Glu Lys Met Val Tyr Met Thr Val Asn 

    290                 295                 300                 





Asp Ser Gln Pro Glu Asp Glu Asp Leu Asn Val Ala Glu Ile Ala Asp 

305                 310                 315                 320 





Glu Val Tyr Met Glu Val Ile Val Gly Glu Glu Asp Ala Ala Ala Ala 

                325                 330                 335     





Ala Ala Ala Ala Ala Val His Glu Gln Gln Met Asp Asp Asn Glu Ile 

            340                 345                 350         





Lys Thr Phe Met Pro Ile Ala Trp Ala Ala Ala Tyr Gly Asn Asn Ser 

        355                 360                 365             





Asp Gly Ile Glu Asn Arg Asn Gly Thr Ala Ser Ala Leu Leu His Ile 

    370                 375                 380                 





Asp Glu Ser Ala Gly Leu Gly Arg Leu Ala Lys Gln Lys Pro Lys Lys 

385                 390                 395                 400 





Arg Arg Arg Pro Asp Ser Arg Gln Tyr Gln Thr Ala Ile Ile Ile Gly 

                405                 410                 415     





Pro Asp Gly His Pro Leu Thr Val Tyr Pro Cys Met Ile Cys Gly Lys 

            420                 425                 430         





Lys Phe Lys Ser Arg Gly Phe Leu Lys Arg His Met Lys Asn His Pro 

        435                 440                 445             





Glu His Leu Ala Lys Lys Lys Tyr Arg Cys Thr Asp Cys Asp Tyr Thr 

    450                 455                 460                 





Thr Asn Lys Lys Ile Ser Leu His Asn His Leu Glu Ser His Lys Leu 

465                 470                 475                 480 





Thr Ser Lys Ala Glu Lys Ala Ile Glu Cys Asp Glu Cys Gly Lys His 

                485                 490                 495     





Phe Ser His Ala Gly Ala Leu Phe Thr His Lys Met Val His Lys Glu 

            500                 505                 510         





Lys Gly Ala Asn Lys Met His Lys Cys Lys Phe Cys Glu Tyr Glu Thr 

        515                 520                 525             





Ala Glu Gln Gly Leu Leu Asn Arg His Leu Leu Ala Val His Ser Lys 

    530                 535                 540                 





Asn Phe Pro His Ile Cys Val Glu Cys Gly Lys Gly Phe Arg His Pro 

545                 550                 555                 560 





Ser Glu Leu Lys Lys His Met Arg Ile His Thr Gly Glu Lys Pro Tyr 

                565                 570                 575     





Gln Cys Gln Tyr Cys Glu Tyr Arg Ser Ala Asp Ser Ser Asn Leu Lys 

            580                 585                 590         





Thr His Val Lys Thr Lys His Ser Lys Glu Met Pro Phe Lys Cys Asp 

        595                 600                 605             





Ile Cys Leu Leu Thr Phe Ser Asp Thr Lys Glu Val Gln Gln His Ala 

    610                 615                 620                 





Leu Ile His Gln Glu Ser Lys Thr His Gln Cys Leu His Cys Asp His 

625                 630                 635                 640 





Lys Ser Ser Asn Ser Ser Asp Leu Lys Arg His Ile Ile Ser Val His 

                645                 650                 655     





Thr Lys Asp Tyr Pro His Lys Cys Asp Met Cys Asp Lys Gly Phe His 

            660                 665                 670         





Arg Pro Ser Glu Leu Lys Lys His Val Ala Ala His Lys Gly Lys Lys 

        675                 680                 685             





Met His Gln Cys Arg His Cys Asp Phe Lys Ile Ala Asp Pro Phe Val 

    690                 695                 700                 





Leu Ser Arg His Ile Leu Ser Val His Thr Lys Asp Leu Pro Phe Arg 

705                 710                 715                 720 





Cys Lys Arg Cys Arg Lys Gly Phe Arg Gln Gln Ser Glu Leu Lys Lys 

                725                 730                 735     





His Met Lys Thr His Ser Gly Arg Lys Val Tyr Gln Cys Glu Tyr Cys 

            740                 745                 750         





Glu Tyr Ser Thr Thr Asp Ala Ser Gly Phe Lys Arg His Val Ile Ser 

        755                 760                 765             





Ile His Thr Lys Asp Tyr Pro His Arg Cys Glu Tyr Cys Lys Lys Gly 

    770                 775                 780                 





Phe Arg Arg Pro Ser Glu Lys Asn Gln His Ile Met Arg His His Lys 

785                 790                 795                 800 





Glu Val Gly Leu Pro 

                805 





<210>  299

<211>  1249

<212>  DNA

<213>  Homo sapiens



<400>  299

cgcgaaaagc cgggactgga cctcgcggag ttgtgcttgt cgccgaagcg gggtgggctt       60



gttcgttccg cgcagccgca gccagaaccg ggtgacgctt atccccgctg tctttccagt      120



ccagggccgc tgagagtggg ggtggctggg agcagcgcag cctccggagg aggaggcgga      180



ggccgaggac caggaatcac cttcaagcct atgtcgtgag gctttggcag aaattaagaa      240



ggaaatatct ccattgttca ttggcatgga aaaatgttca gtgggaggat tagagttgac      300



tgaacagact cctgctttat tagggaatat ggccatggca actagtctca tggacatagg      360



ggattcattt ggtcatccag cttgtccttt agtcagtaga tctaggaact caccagtgga      420



agatgatgat gatgatgatg atgttgtgtt tattgaatct atacaacctc cttcaatttc      480



tgctccagca atagctgatc aaagaaactt catatttgca tcatcaaaaa atgaaaagcc      540



tcaaggaaat tattctgtaa ttcctccttc ttcaagagat ttggcatctc agaaaggaaa      600



tataagtgag acaattgtta ttgatgatga agaggacata gaaacaaatg gaggagcaga      660



gaaaaagtct tcctgtttta tcgaatgggg acttcctgga actaaaaaca aaaccaacga      720



tttggatttc tccacttcca gtctttcaag aagtaagacc aagactggag taagaccttt      780



taaccctggt agaatgaatg tggcaggaga cttatttcag aatggagaat ttgcaactca      840



tcatagtcct gagatgcatc tacaaagaag gctaatgtca ttcttccagt agaatcaagc      900



aaatccttcc aagaatttta tagtacatct tgtttgtctc cctgtgaaaa caactggaat      960



cttaaaaaag gagtttttaa taagtcaaga tgtacaattt gtagtaaatt agcagaggtc     1020



tggattttta tacctaagtt gttgtttagg ctaacagtga taattttaac ttttaagtgc     1080



tattatgtac tctttcatct acataatgca cgtgttctgg atgtataaca tgaagctgaa     1140



aggaagaata aggatatgtt agaactatct tatgggatat tttataaata aaattccatt     1200



tgcatagcat ggaaagtaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 1249





<210>  300

<211>  208

<212>  PRT

<213>  Homo sapiens



<400>  300



Met Glu Lys Cys Ser Val Gly Gly Leu Glu Leu Thr Glu Gln Thr Pro 

1               5                   10                  15      





Ala Leu Leu Gly Asn Met Ala Met Ala Thr Ser Leu Met Asp Ile Gly 

            20                  25                  30          





Asp Ser Phe Gly His Pro Ala Cys Pro Leu Val Ser Arg Ser Arg Asn 

        35                  40                  45              





Ser Pro Val Glu Asp Asp Asp Asp Asp Asp Asp Val Val Phe Ile Glu 

    50                  55                  60                  





Ser Ile Gln Pro Pro Ser Ile Ser Ala Pro Ala Ile Ala Asp Gln Arg 

65                  70                  75                  80  





Asn Phe Ile Phe Ala Ser Ser Lys Asn Glu Lys Pro Gln Gly Asn Tyr 

                85                  90                  95      





Ser Val Ile Pro Pro Ser Ser Arg Asp Leu Ala Ser Gln Lys Gly Asn 

            100                 105                 110         





Ile Ser Glu Thr Ile Val Ile Asp Asp Glu Glu Asp Ile Glu Thr Asn 

        115                 120                 125             





Gly Gly Ala Glu Lys Lys Ser Ser Cys Phe Ile Glu Trp Gly Leu Pro 

    130                 135                 140                 





Gly Thr Lys Asn Lys Thr Asn Asp Leu Asp Phe Ser Thr Ser Ser Leu 

145                 150                 155                 160 





Ser Arg Ser Lys Thr Lys Thr Gly Val Arg Pro Phe Asn Pro Gly Arg 

                165                 170                 175     





Met Asn Val Ala Gly Asp Leu Phe Gln Asn Gly Glu Phe Ala Thr His 

            180                 185                 190         





His Ser Pro Glu Met His Leu Gln Arg Arg Leu Met Ser Phe Phe Gln 

        195                 200                 205             





<210>  301

<211>  1535

<212>  DNA

<213>  Homo sapiens



<400>  301

cgcgaaaagc cgggactgga cctcgcggag ttgtgcttgt cgccgaagcg gggtgggctt       60



gttcgttccg cgcagccgca gccagaaccg ggtgacgctt atccccgctg tctttccagt      120



ccagggccgc tgagagtggg ggtggctggg agcagcgcag cctccggagg aggaggcgga      180



ggccgaggac caggaatcac cttcaagcct atgtcgtgag gctttggcag aaattaagaa      240



ggaaatatct ccattgttca ttggcatgga aaaatgttca gtgggaggat tagagttgac      300



tgaacagact cctgctttat tagggaatat ggccatggca actagtctca tggacatagg      360



ggattcattt ggtcatccag cttgtccttt agtcagtaga tctaggaact caccagtgga      420



agatgatgat gatgatgatg atgttgtgtt tattgaatct atacaacctc cttcaatttc      480



tgctccagca atagctgatc aaagaaactt catatttgca tcatcaaaaa atgaaaagcc      540



tcaaggaaat tattctgtaa ttcctccttc ttcaagagat ttggcatctc agaaaggaaa      600



tataagtgag acaattgtta ttgatgatga agaggacata gaaacaaatg gaggagcaga      660



gaaaaagtct tcctgtttta tcgaatgggg acttcctgga actaaaaaca aaaccaacga      720



tttggatttc tccacttcca gtctttcaag aagtaagacc aagactggag taagaccttt      780



taaccctggt agaatgaatg tggcaggaga cttatttcag aatggagaat ttgcaactca      840



tcatagtcct gattcttgga tctcccagtc agcttcattt cccagtaatc agaaacagcc      900



aggggtggat tctttatcac cagtggcctt acttcgtaag cagaatttcc agcctacagc      960



ccaacaacaa cttactaaac cagctaaaat cacttgtgca aattgcaaaa agcctttaca     1020



gaagggacag acagcttatc aacgaaaagg atcagctcac ctcttttgct ctaccacctg     1080



cctttcttcc ttctctcata aacgtactca aaacacacga agcataatat gtaaaaaaga     1140



tgcatctaca aagaaggcta atgtcattct tccagtagaa tcaagcaaat ccttccaaga     1200



attttatagt acatcttgtt tgtctccctg tgaaaacaac tggaatctta aaaaaggagt     1260



ttttaataag tcaagatgta caatttgtag taaattagca gaggtctgga tttttatacc     1320



taagttgttg tttaggctaa cagtgataat tttaactttt aagtgctatt atgtactctt     1380



tcatctacat aatgcacgtg ttctggatgt ataacatgaa gctgaaagga agaataagga     1440



tatgttagaa ctatcttatg ggatatttta taaataaaat tccatttgca tagcatggaa     1500



agtacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                1535





<210>  302

<211>  382

<212>  PRT

<213>  Homo sapiens



<400>  302



Met Glu Lys Cys Ser Val Gly Gly Leu Glu Leu Thr Glu Gln Thr Pro 

1               5                   10                  15      





Ala Leu Leu Gly Asn Met Ala Met Ala Thr Ser Leu Met Asp Ile Gly 

            20                  25                  30          





Asp Ser Phe Gly His Pro Ala Cys Pro Leu Val Ser Arg Ser Arg Asn 

        35                  40                  45              





Ser Pro Val Glu Asp Asp Asp Asp Asp Asp Asp Val Val Phe Ile Glu 

    50                  55                  60                  





Ser Ile Gln Pro Pro Ser Ile Ser Ala Pro Ala Ile Ala Asp Gln Arg 

65                  70                  75                  80  





Asn Phe Ile Phe Ala Ser Ser Lys Asn Glu Lys Pro Gln Gly Asn Tyr 

                85                  90                  95      





Ser Val Ile Pro Pro Ser Ser Arg Asp Leu Ala Ser Gln Lys Gly Asn 

            100                 105                 110         





Ile Ser Glu Thr Ile Val Ile Asp Asp Glu Glu Asp Ile Glu Thr Asn 

        115                 120                 125             





Gly Gly Ala Glu Lys Lys Ser Ser Cys Phe Ile Glu Trp Gly Leu Pro 

    130                 135                 140                 





Gly Thr Lys Asn Lys Thr Asn Asp Leu Asp Phe Ser Thr Ser Ser Leu 

145                 150                 155                 160 





Ser Arg Ser Lys Thr Lys Thr Gly Val Arg Pro Phe Asn Pro Gly Arg 

                165                 170                 175     





Met Asn Val Ala Gly Asp Leu Phe Gln Asn Gly Glu Phe Ala Thr His 

            180                 185                 190         





His Ser Pro Asp Ser Trp Ile Ser Gln Ser Ala Ser Phe Pro Ser Asn 

        195                 200                 205             





Gln Lys Gln Pro Gly Val Asp Ser Leu Ser Pro Val Ala Leu Leu Arg 

    210                 215                 220                 





Lys Gln Asn Phe Gln Pro Thr Ala Gln Gln Gln Leu Thr Lys Pro Ala 

225                 230                 235                 240 





Lys Ile Thr Cys Ala Asn Cys Lys Lys Pro Leu Gln Lys Gly Gln Thr 

                245                 250                 255     





Ala Tyr Gln Arg Lys Gly Ser Ala His Leu Phe Cys Ser Thr Thr Cys 

            260                 265                 270         





Leu Ser Ser Phe Ser His Lys Arg Thr Gln Asn Thr Arg Ser Ile Ile 

        275                 280                 285             





Cys Lys Lys Asp Ala Ser Thr Lys Lys Ala Asn Val Ile Leu Pro Val 

    290                 295                 300                 





Glu Ser Ser Lys Ser Phe Gln Glu Phe Tyr Ser Thr Ser Cys Leu Ser 

305                 310                 315                 320 





Pro Cys Glu Asn Asn Trp Asn Leu Lys Lys Gly Val Phe Asn Lys Ser 

                325                 330                 335     





Arg Cys Thr Ile Cys Ser Lys Leu Ala Glu Val Trp Ile Phe Ile Pro 

            340                 345                 350         





Lys Leu Leu Phe Arg Leu Thr Val Ile Ile Leu Thr Phe Lys Cys Tyr 

        355                 360                 365             





Tyr Val Leu Phe His Leu His Asn Ala Arg Val Leu Asp Val 

    370                 375                 380         





<210>  303

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  303

ctccacctct tcttcctccc                                                   20





<210>  304

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  304

tccacctctt cttcctccc                                                    19





<210>  305

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  305

cctccacctc ttcttcctcc                                                   20





<210>  306

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  306

acctccacct cttcttcctc c                                                 21





<210>  307

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  307

tccacctctt cttcctcccg                                                   20





<210>  308

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  308

cacctccacc tcttcttcct c                                                 21





<210>  309

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  309

acctccacct cttcttcctc                                                   20





<210>  310

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  310

tccacctctt cttcctcccg a                                                 21





<210>  311

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  311

ccacctcttc ttcctcccga                                                   20





<210>  312

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  312

ctccacctct tcttcctcc                                                    19





<210>  313

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  313

tccacctacc actcccagca                                                   20





<210>  314

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  314

gttcgtctcc ttctctctcc c                                                 21





<210>  315

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  315

gtctccttct ctctccctg                                                    19





<210>  316

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  316

tcgtctcctt ctctctccct                                                   20





<210>  317

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  317

tccttcttgt ctcctccctt                                                   20





<210>  318

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  318

ttccttcttg tctcctccct                                                   20





<210>  319

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  319

tgtccaccta ccactcccag                                                   20





<210>  320

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  320

gtgccactct gtctcctttg c                                                 21





<210>  321

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  321

tctccttctc tctccctggc t                                                 21





<210>  322

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  322

ttcgtctcct tctctctccc t                                                 21





<210>  323

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  323

gccacttcat tgtccgtccc t                                                 21





<210>  324

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  324

gccacttcat tgtccgtccc                                                   20





<210>  325

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  325

ctgcctctgt ctccctttg                                                    19





<210>  326

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  326

gctgcctctg tctccctttg                                                   20





<210>  327

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  327

gctgcctctg tctcccttt                                                    19





<210>  328

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  328

ctgcctctgt ctccctttgg                                                   20





<210>  329

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  329

ccacttcatt gtccgtccct c                                                 21





<210>  330

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  330

ccctgagtcc acttgtccct                                                   20





<210>  331

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  331

gccaatctct cccttgtacc c                                                 21





<210>  332

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  332

gctctccctt ggctcctttc t                                                 21





<210>  333

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  333

tcctcacttc cctcatcctc c                                                 21





<210>  334

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  334

cctcacttcc ctcatcctcc                                                   20





<210>  335

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  335

cctcacttcc ctcatcctcc a                                                 21





<210>  336

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  336

ctcctcactt ccctcatcct c                                                 21





<210>  337

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  337

gctcctcact tccctcatcc t                                                 21





<210>  338

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  338

ctcctcactt ccctcatcct                                                   20





<210>  339

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  339

tcctcacttc cctcatcctc                                                   20





<210>  340

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  340

cttccctcat cctccatctc t                                                 21





<210>  341

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  341

gctcctcact tccctcatcc                                                   20





<210>  342

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  342

ctcacttccc tcatcctcca                                                   20





<210>  343

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  343

gtcactcacc ctccagacct                                                   20





<210>  344

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  344

tcactcaccc tccagacctt                                                   20





<210>  345

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  345

gtcactcacc ctccagacct t                                                 21





<210>  346

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  346

tcactcaccc tccagacct                                                    19





<210>  347

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  347

tcactcaccc tccagacctt t                                                 21





<210>  348

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  348

ccaccatggc tccctcctta                                                   20





<210>  349

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  349

ggtatctctg ttggcttccc                                                   20





<210>  350

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  350

cactcaccct ccagaccttt                                                   20





<210>  351

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  351

aggtatctct gttggcttcc c                                                 21





<210>  352

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  352

cactcaccct ccagacctt                                                    19





<210>  353

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  353

ccacccttta cctctctgcc a                                                 21





<210>  354

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  354

ccacccttta cctctctgcc                                                   20





<210>  355

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  355

cccacccttt acctctctgc                                                   20





<210>  356

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  356

cccacccttt acctctctg                                                    19





<210>  357

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  357

ccacccttta cctctctgc                                                    19





<210>  358

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  358

gccatgtatg ttccgttccc                                                   20





<210>  359

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  359

caccctttac ctctctgcca                                                   20





<210>  360

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  360

accctttacc tctctgcca                                                    19





<210>  361

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  361

caccctttac ctctctgcc                                                    19





<210>  362

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  362

ccctttacct ctctgccagt                                                   20





<210>  363

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  363

ccctgcttct ctgtcttccc                                                   20





<210>  364

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  364

tccctgccac ccatcaacca                                                   20





<210>  365

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  365

agtccctgcc acccatcaa                                                    19





<210>  366

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  366

accctgcttc tctgtcttcc c                                                 21





<210>  367

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  367

gtcagcgtgt ttcccttccc t                                                 21





<210>  368

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  368

gcttctttgt catcctccca c                                                 21





<210>  369

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  369

gtcagcgtgt ttcccttccc                                                   20





<210>  370

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  370

cagtccctgc cacccatcaa                                                   20





<210>  371

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  371

cctgcttctc tgtcttccc                                                    19





<210>  372

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  372

agtccctgcc acccatcaac                                                   20





<210>  373

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  373

ccttcttccc attctccacc                                                   20





<210>  374

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  374

ccttcttccc attctccacc a                                                 21





<210>  375

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  375

accttcttcc cattctccac c                                                 21





<210>  376

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  376

ctctgccatg tcctccacct                                                   20





<210>  377

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  377

ctctgccatg tcctccacct t                                                 21





<210>  378

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  378

caccttcttc ccattctcca c                                                 21





<210>  379

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  379

cttcttccca ttctccacca                                                   20





<210>  380

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  380

tcttcgccca cctcctcctt                                                   20





<210>  381

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  381

accttcttcc cattctccac                                                   20





<210>  382

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  382

tcttcccatt ctccaccagc                                                   20





<210>  383

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  383

cctcttcctc ttcactctcc t                                                 21





<210>  384

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  384

cctcttcctc ttcactctcc                                                   20





<210>  385

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  385

acctcttcct cttcactctc c                                                 21





<210>  386

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  386

ctcttcctct tcactctcct c                                                 21





<210>  387

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  387

tcttcctctt cactctcctc t                                                 21





<210>  388

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  388

cttcctcttc actctcctct                                                   20





<210>  389

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  389

ctcttcctct tcactctcct                                                   20





<210>  390

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  390

tcttcctctt cactctcctc                                                   20





<210>  391

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  391

cttcctcttc actctcctct t                                                 21





<210>  392

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  392

acctcttcct cttcactctc                                                   20





<210>  393

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  393

gtcaccttgc caccctctgt                                                   20





<210>  394

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  394

tcagtcacct tgccaccctc t                                                 21





<210>  395

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  395

gtcagtcacc ttgccaccct                                                   20





<210>  396

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  396

cagtcacctt gccaccctct                                                   20





<210>  397

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  397

agtcaccttg ccaccctctg t                                                 21





<210>  398

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  398

agtcaccttg ccaccctctg                                                   20





<210>  399

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  399

gatccacagc ccagttccca                                                   20





<210>  400

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  400

gtctctttcc tcctgccttc c                                                 21





<210>  401

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  401

agtcaccttg ccaccctct                                                    19





<210>  402

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  402

tcagtcacct tgccaccctc                                                   20





<210>  403

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  403

tccactcctc cctctcgtct                                                   20





<210>  404

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  404

atccactcct ccctctcgtc t                                                 21





<210>  405

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  405

atccactcct ccctctcgtc                                                   20





<210>  406

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  406

catccactcc tccctctcgt                                                   20





<210>  407

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  407

atccactcct ccctctcgt                                                    19





<210>  408

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  408

tcttcccacc tcacctcagc                                                   20





<210>  409

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  409

tcccacctca cctcagcctt                                                   20





<210>  410

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  410

ttcccacctc acctcagcct                                                   20





<210>  411

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  411

ttcccacctc acctcagcct t                                                 21





<210>  412

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  412

atcttcccac ctcacctcag c                                                 21





<210>  413

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  413

ctccctccag tgctctcaga                                                   20





<210>  414

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  414

tgctccctcc agtgctctca                                                   20





<210>  415

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  415

tccctccagt gctctcaga                                                    19





<210>  416

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  416

gccagcttga agagactccc a                                                 21





<210>  417

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  417

cctcctcttc caaccttcgc t                                                 21





<210>  418

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  418

gccagcttga agagactccc                                                   20





<210>  419

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  419

tctagattcg ctgctccctc c                                                 21





<210>  420

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  420

ctccctccag tgctctcaga a                                                 21





<210>  421

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  421

cctcctcttc caaccttcgc                                                   20





<210>  422

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  422

gcctcctctt ccaaccttcg                                                   20





<210>  423

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  423

gtccttctcg ccctccttct                                                   20





<210>  424

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  424

cttctcgccc tccttctcct                                                   20





<210>  425

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  425

ttctcgccct ccttctcctc                                                   20





<210>  426

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  426

tccttctcgc cctccttctc                                                   20





<210>  427

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  427

cgcatcactc ccaactccca                                                   20





<210>  428

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  428

gtggtgtgtt ggtgtctgtg                                                   20





<210>  429

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  429

acgcatcact cccaactccc a                                                 21





<210>  430

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  430

acgcatcact cccaactccc                                                   20





<210>  431

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  431

gcatcactcc caactcccat                                                   20





<210>  432

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  432

gcatcactcc caactccca                                                    19





<210>  433

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  433

ccctccctca tcttcctctt c                                                 21





<210>  434

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  434

ccctccctca tcttcctctt                                                   20





<210>  435

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  435

ccctccctca tcttcctct                                                    19





<210>  436

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  436

cctccctcat cttcctcttc t                                                 21





<210>  437

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  437

cctccctcat cttcctcttc                                                   20





<210>  438

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  438

ctccctcatc ttcctcttct                                                   20





<210>  439

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  439

cctccctcat cttcctctt                                                    19





<210>  440

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  440

ctccctcatc ttcctcttct t                                                 21





<210>  441

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  441

gttcttctgc ccacttcctc t                                                 21





<210>  442

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  442

ctccctcatc ttcctcttc                                                    19





<210>  443

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  443

accacagcac cctactctcc                                                   20





<210>  444

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  444

ctcctctgac gcacttccct                                                   20





<210>  445

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  445

tcctctgacg cacttccctg                                                   20





<210>  446

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  446

tcctctgacg cacttccct                                                    19





<210>  447

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  447

ccgtctccac aatcccactg                                                   20





<210>  448

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  448

caccgtctcc acaatcccac t                                                 21





<210>  449

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  449

ccgtctccac aatcccact                                                    19





<210>  450

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  450

accacagcac cctactctc                                                    19





<210>  451

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  451

accgtctcca caatcccact                                                   20





<210>  452

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  452

caccgtctcc acaatcccac                                                   20





<210>  453

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  453

ctcccagcct ccactcaact                                                   20





<210>  454

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  454

actcccagcc tccactcaac t                                                 21





<210>  455

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  455

actcccagcc tccactcaac                                                   20





<210>  456

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  456

ctcccagcct ccactcaact a                                                 21





<210>  457

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  457

tcccagcctc cactcaact                                                    19





<210>  458

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  458

actcccagcc tccactcaa                                                    19





<210>  459

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  459

aactcccagc ctccactca                                                    19





<210>  460

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  460

tcccagcctc cactcaacta c                                                 21





<210>  461

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  461

tcttcttctg tccacttccc t                                                 21





<210>  462

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  462

tcccagcctc cactcaacta                                                   20





<210>  463

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  463

gcattcccac cttccactcc t                                                 21





<210>  464

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  464

cattcccacc ttccactcct                                                   20





<210>  465

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  465

gcattcccac cttccactcc                                                   20





<210>  466

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  466

cattcccacc ttccactcct a                                                 21





<210>  467

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  467

ttcccacctt ccactccta                                                    19





<210>  468

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  468

attcccacct tccactcct                                                    19





<210>  469

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  469

cattcccacc ttccactcc                                                    19





<210>  470

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  470

ttcccacctt ccactcctat                                                   20





<210>  471

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  471

attcccacct tccactccta                                                   20





<210>  472

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  472

tcccaccttc cactcctat                                                    19





<210>  473

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  473

gtccactcac ctccatacca                                                   20





<210>  474

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  474

gtccactcac ctccatacc                                                    19





<210>  475

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  475

tccactcacc tccatacca                                                    19





<210>  476

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  476

gtccactcac ctccatacca a                                                 21





<210>  477

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  477

tccactcacc tccataccaa                                                   20





<210>  478

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  478

ccactcacct ccataccaag c                                                 21





<210>  479

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  479

ccactcacct ccataccaa                                                    19





<210>  480

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  480

tccactcacc tccataccaa g                                                 21





<210>  481

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  481

ccactcacct ccataccaag                                                   20





<210>  482

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  482

atgccaaggg tccactcac                                                    19





<210>  483

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  483

accacctccc attccaccca                                                   20





<210>  484

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  484

acctcccata ccacctccca                                                   20





<210>  485

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  485

taccacctcc cattccaccc                                                   20





<210>  486

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  486

taccacctcc cattccaccc a                                                 21





<210>  487

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  487

ccacctccca ttccacccat                                                   20





<210>  488

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  488

cctcccatac cacctcccat                                                   20





<210>  489

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  489

tgccacctcc cataccacct                                                   20





<210>  490

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  490

accacctccc attccaccca t                                                 21





<210>  491

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  491

acctcccata ccacctccca t                                                 21





<210>  492

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  492

ccacctccca ttccacccat t                                                 21





<210>  493

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  493

gtcccgcaca ccctcttctt                                                   20





<210>  494

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  494

gtcccgcaca ccctcttctt t                                                 21





<210>  495

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  495

tcccgcacac cctcttcttt                                                   20





<210>  496

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  496

tcccgcacac cctcttctt                                                    19





<210>  497

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  497

tcccgcacac cctcttcttt a                                                 21





<210>  498

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  498

ccctgtgcct tcttcttcct                                                   20





<210>  499

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  499

ccctgtgcct tcttcttcct t                                                 21





<210>  500

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  500

actccacctt gttcactgcc a                                                 21





<210>  501

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  501

gacttcccga gccattcctt c                                                 21





<210>  502

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  502

tccaccatgt tctccactcg c                                                 21





<210>  503

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  503

ctctgttctt ctctcttcc                                                    19





<210>  504

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  504

gctccgtgtt ctgactcttg                                                   20





<210>  505

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  505

gtgtttccat cctccgcctc                                                   20





<210>  506

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  506

gctccgtgtt ctgactctt                                                    19





<210>  507

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  507

tgtttccatc ctccgcctcc                                                   20





<210>  508

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  508

cactctgttc ttctctcttc c                                                 21





<210>  509

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  509

actctgttct tctctcttcc a                                                 21





<210>  510

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  510

gtgtttccat cctccgcct                                                    19





<210>  511

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  511

ctctgttctt ctctcttcca                                                   20





<210>  512

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  512

actctgttct tctctcttcc                                                   20





<210>  513

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  513

tctcccacat ctgctttgcc c                                                 21





<210>  514

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  514

ctcccacatc tgctttgccc                                                   20





<210>  515

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  515

tcccacatct gctttgcccg a                                                 21





<210>  516

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  516

tcccacatct gctttgcccg                                                   20





<210>  517

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  517

tctcccacat ctgctttgcc                                                   20





<210>  518

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  518

tcccacatct gctttgccc                                                    19





<210>  519

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  519

aagctctccg tccttgccac                                                   20





<210>  520

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  520

atctcccaca tctgctttgc c                                                 21





<210>  521

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  521

cactttcctg tccttgggcg t                                                 21





<210>  522

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  522

ctcccacatc tgctttgcc                                                    19





<210>  523

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  523

ctgtggctgg gtctgtctgt                                                   20





<210>  524

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  524

tgtggctggg tctgtctgtc                                                   20





<210>  525

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  525

ggtctgtctg tcctctggct                                                   20





<210>  526

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  526

gctgggtctg tctgtcctct                                                   20





<210>  527

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  527

gtctgtctgt cctctggctt                                                   20





<210>  528

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  528

gtctgtctgt cctctggct                                                    19





<210>  529

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  529

ggtctgtctg tcctctggct t                                                 21





<210>  530

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  530

gtctgtctgt cctctggctt g                                                 21





<210>  531

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  531

ggtttgggct ctggatggtc t                                                 21





<210>  532

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  532

gggtttgggc tctggatggt                                                   20





<210>  533

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  533

ccactccctg cctcctgata                                                   20





<210>  534

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  534

ccactccctg cctcctgata t                                                 21





<210>  535

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  535

cactccctgc ctcctgatat                                                   20





<210>  536

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  536

cactccctgc ctcctgata                                                    19





<210>  537

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  537

gtggtggtgt gatgggtgtg t                                                 21





<210>  538

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  538

cactccctgc ctcctgatat g                                                 21





<210>  539

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  539

actccctgcc tcctgatatg                                                   20





<210>  540

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  540

gcctccactc atccagattc c                                                 21





<210>  541

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  541

actccctgcc tcctgatat                                                    19





<210>  542

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  542

ggtggtgtga tgggtgtgtg                                                   20





<210>  543

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  543

actcctccct ttctctcatt                                                   20





<210>  544

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  544

actcctccct ttctctcat                                                    19





<210>  545

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  545

gactcctccc tttctctca                                                    19





<210>  546

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  546

gactcctccc tttctctcat                                                   20





<210>  547

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  547

actcctccct ttctctcatt g                                                 21





<210>  548

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  548

gactcctccc tttctctcat t                                                 21





<210>  549

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  549

ctcctccctt tctctcatt                                                    19





<210>  550

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  550

ctcctccctt tctctcattg                                                   20





<210>  551

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  551

tcctcccttt ctctcattg                                                    19





<210>  552

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  552

ctcctccctt tctctcattg a                                                 21





<210>  553

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  553

tgtcgggtag cttatcaga                                                    19





<210>  554

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  554

gtcgggtagc ttatcagact                                                   20





<210>  555

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  555

cttatcagac tgatgttgac t                                                 21





<210>  556

<211>  25

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  556

ttatcagact gatgttgact gttga                                             25





<210>  557

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  557

gactgatgtt gactgttgaa                                                   20





<210>  558

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  558

tgttgactgt tgaatctcat                                                   20





<210>  559

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  559

gttgactgtt gaatctcatg gcaa                                              24





<210>  560

<211>  22

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  560

caccagtcga tgggctgtct ga                                                22





<210>  561

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  561

tcagactgat gttgactgtt gaat                                              24





<210>  562

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  562

gactgttgaa tctcatggca a                                                 21





<210>  563

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  563

cccttcatgc ttcactttcc c                                                 21





<210>  564

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  564

tcccttcatg cttcactttc c                                                 21





<210>  565

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  565

ccttcatgct tcactttccc                                                   20





<210>  566

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  566

ccctccgcca tgaccatagt                                                   20





<210>  567

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  567

acttccacac accttcatct                                                   20





<210>  568

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  568

acttccacac accttcatct t                                                 21





<210>  569

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  569

cttccacaca ccttcatctt                                                   20





<210>  570

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  570

tacttccaca caccttcatc t                                                 21





<210>  571

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  571

cttccacaca ccttcatct                                                    19





<210>  572

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  572

tccgccatga ccatagtgcc                                                   20





<210>  573

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  573

gcacttacat cacccactcc a                                                 21





<210>  574

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  574

cacttacatc acccactcca                                                   20





<210>  575

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  575

gcacttacat cacccactcc                                                   20





<210>  576

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  576

cacttacatc acccactcc                                                    19





<210>  577

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  577

acttacatca cccactcca                                                    19





<210>  578

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  578

cctttctcct gttcttgttc                                                   20





<210>  579

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  579

cacttacatc acccactcca a                                                 21





<210>  580

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  580

cttcatccct gccttcgtt                                                    19





<210>  581

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  581

acccatgcct ccactgtctt                                                   20





<210>  582

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  582

actccacttt aacttcatcc c                                                 21





<210>  583

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  583

gttcccgttc cctctcagca                                                   20





<210>  584

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  584

ttcccgttcc ctctcagcac                                                   20





<210>  585

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  585

cccattccct ctgcctgtga                                                   20





<210>  586

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  586

tcccgttccc tctcagcact                                                   20





<210>  587

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  587

gttccctcgc atccttgtcc                                                   20





<210>  588

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  588

tcccgttccc tctcagcact t                                                 21





<210>  589

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  589

ttcccgttcc ctctcagcac t                                                 21





<210>  590

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  590

ttcccgttcc ctctcagca                                                    19





<210>  591

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  591

cccgttccct ctcagcactt                                                   20





<210>  592

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  592

cccttcctct cttcgtgtct c                                                 21





<210>  593

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  593

gtccgctgtg tctccctttc                                                   20





<210>  594

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  594

tccgctgtgt ctccctttcc                                                   20





<210>  595

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  595

gtccgctgtg tctcccttt                                                    19





<210>  596

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  596

tccgctgtgt ctccctttc                                                    19





<210>  597

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  597

tgcctccttc catgtcctcc                                                   20





<210>  598

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  598

cctccttcca tgtcctccgt                                                   20





<210>  599

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  599

tccttccatg tcctccgtcc                                                   20





<210>  600

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  600

ggtccgctgt gtctcccttt                                                   20





<210>  601

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  601

tccttccatg tcctccgtcc a                                                 21





<210>  602

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  602

ctccttccat gtcctccgtc                                                   20





<210>  603

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  603

cctccacctc cttctgcctt                                                   20





<210>  604

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  604

tcttgtgtcg cctcctccca                                                   20





<210>  605

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  605

cctccacctc cttctgcctt t                                                 21





<210>  606

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  606

atcttgtgtc gcctcctccc                                                   20





<210>  607

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  607

atcttgtgtc gcctcctccc a                                                 21





<210>  608

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  608

tcccatcttg tgtcgcctcc t                                                 21





<210>  609

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  609

cctcccatct tgtgtcgcct                                                   20





<210>  610

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  610

tcccatcttg tgtcgcctcc                                                   20





<210>  611

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  611

ctccacctcc ttctgccttt                                                   20





<210>  612

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  612

ctccacctcc ttctgcctt                                                    19





<210>  613

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  613

acccacctcc tttcctcagc                                                   20





<210>  614

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  614

gacccacctc ctttcctcag                                                   20





<210>  615

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  615

acccacctcc tttcctcag                                                    19





<210>  616

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  616

gacccacctc ctttcctca                                                    19





<210>  617

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  617

gcctagaccc acctcctttc                                                   20





<210>  618

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  618

cctagaccca cctcctttcc t                                                 21





<210>  619

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  619

tccactcctt ctgttccgtc a                                                 21





<210>  620

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  620

tccactcctt ctgttccgtc                                                   20





<210>  621

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  621

ctgcctagac ccacctcctt                                                   20





<210>  622

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  622

cctagaccca cctcctttcc                                                   20





<210>  623

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  623

tccctgctcc cgactcttca                                                   20





<210>  624

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  624

tccctgctcc cgactcttca t                                                 21





<210>  625

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  625

ccctgctccc gactcttcat                                                   20





<210>  626

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  626

ccctgctccc gactcttcat t                                                 21





<210>  627

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  627

cctgctcccg actcttcatt c                                                 21





<210>  628

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  628

cctgctcccg actcttcatt                                                   20





<210>  629

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  629

cctgctcccg actcttcat                                                    19





<210>  630

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  630

ctgctcccga ctcttcattc                                                   20





<210>  631

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  631

ggtcctctgc actcctttgt c                                                 21





<210>  632

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  632

gcctgtgcca cttctttgct                                                   20





<210>  633

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  633

tcctcttctt cctccttctc t                                                 21





<210>  634

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  634

catccctctc atatcgccac a                                                 21





<210>  635

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  635

tccctctcat atcgccacag                                                   20





<210>  636

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  636

cctcttcttc ctccttctct                                                   20





<210>  637

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  637

catccctctc atatcgccac                                                   20





<210>  638

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  638

tcctcttctt cctccttctc                                                   20





<210>  639

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  639

atccctctca tatcgccaca g                                                 21





<210>  640

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  640

atccctctca tatcgccaca                                                   20





<210>  641

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  641

cctcttcttc ctccttctct t                                                 21





<210>  642

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  642

tccctctcat atcgccaca                                                    19





<210>  643

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  643

attctcctgc cacagcctcc                                                   20





<210>  644

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  644

gctcacggtg tcttcattcc c                                                 21





<210>  645

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  645

tccattctcg cgcctcctct                                                   20





<210>  646

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  646

acggcctcca cctccattct                                                   20





<210>  647

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  647

agcgattctc ctgccacagc                                                   20





<210>  648

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  648

tccattctcg cgcctcctct t                                                 21





<210>  649

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  649

ccattctcgc gcctcctctt                                                   20





<210>  650

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  650

ggcacatttc cttcccttgc                                                   20





<210>  651

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  651

ggtgagtagc ccagatgcca                                                   20





<210>  652

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  652

agcttctctg cgcctttccg                                                   20





<210>  653

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  653

cacacctgcc aactccacca                                                   20





<210>  654

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  654

cacacctgcc aactccacca t                                                 21





<210>  655

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  655

acacctgcca actccaccat                                                   20





<210>  656

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  656

acacctgcca actccacca                                                    19





<210>  657

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  657

cacctgccaa ctccaccatt                                                   20





<210>  658

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  658

acacctgcca actccaccat t                                                 21





<210>  659

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  659

cacctgccaa ctccaccat                                                    19





<210>  660

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  660

cacctgccaa ctccaccatt g                                                 21





<210>  661

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  661

acctgccaac tccaccatt                                                    19





<210>  662

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  662

acctgccaac tccaccattg                                                   20





<210>  663

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  663

gtcttccgcc accttgatct                                                   20





<210>  664

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  664

gtcttccgcc accttgatct t                                                 21





<210>  665

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  665

gctccacctc cttcatatcc a                                                 21





<210>  666

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  666

gctccacctc cttcatatcc                                                   20





<210>  667

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  667

ccacctcctt catatccacc t                                                 21





<210>  668

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  668

gtcttccgcc accttgatc                                                    19





<210>  669

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  669

tcttccgcca ccttgatctt c                                                 21





<210>  670

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  670

tccacctcct tcatatccac c                                                 21





<210>  671

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  671

actcattcag ctccacctcc t                                                 21





<210>  672

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  672

tctcaccgct cctgccacat                                                   20





<210>  673

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  673

gtcttgtccc attccttcac c                                                 21





<210>  674

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  674

tcttgtccca ttccttcacc a                                                 21





<210>  675

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  675

tcttgtccca ttccttcacc                                                   20





<210>  676

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  676

gtcttgtccc attccttcac                                                   20





<210>  677

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  677

cttgtcccat tccttcacca                                                   20





<210>  678

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  678

gtcccattcc ttcaccagt                                                    19





<210>  679

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  679

tgtcccattc cttcaccagt                                                   20





<210>  680

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  680

gtcttgtccc attccttca                                                    19





<210>  681

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  681

acaaatcttc ctcttctccc                                                   20





<210>  682

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  682

caaatcttcc tcttctccc                                                    19





<210>  683

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  683

tccctcagac agttccttc                                                    19





<210>  684

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  684

atccctcaga cagttccttc                                                   20





<210>  685

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  685

aacaaatctt cctcttctcc c                                                 21





<210>  686

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  686

atccctcaga cagttcctt                                                    19





<210>  687

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  687

aggctctggg actaggaca                                                    19





<210>  688

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  688

cagccagtcc cagtggttca                                                   20





<210>  689

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  689

agccagtccc agtggttcac                                                   20





<210>  690

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  690

tccctcagac agttccttct                                                   20





<210>  691

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  691

cggagctcag tacaggtct                                                    19





<210>  692

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  692

cggagctcag tacaggtctg                                                   20





<210>  693

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  693

ggagctcagt acaggtctg                                                    19





<210>  694

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  694

cacggagctc agtacaggtc t                                                 21





<210>  695

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  695

ctcacggagc tcagtacagg t                                                 21





<210>  696

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  696

tcacggagct cagtacaggt c                                                 21





<210>  697

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  697

cacggagctc agtacaggtc                                                   20





<210>  698

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  698

cagagttatt tatcctcacg g                                                 21





<210>  699

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  699

gagttattta tcctcacgg                                                    19





<210>  700

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  700

agagagagtt cagttcgta                                                    19





<210>  701

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  701

ttctccacta atccatcag                                                    19





<210>  702

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  702

gagagagttc agttcgtaa                                                    19





<210>  703

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  703

tctccactaa tccatcaga                                                    19





<210>  704

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  704

ctccactaat ccatcagaa                                                    19





<210>  705

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  705

ctccactaat ccatcagaaa g                                                 21





<210>  706

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  706

gaaagagaga gttcagttcg t                                                 21





<210>  707

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  707

aagagagagt tcagttcgt                                                    19





<210>  708

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  708

ccatcagaaa gagagagtt                                                    19





<210>  709

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  709

ccatcagaaa gagagagttc a                                                 21





<210>  710

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  710

cttgaaagtt cagccatatg c                                                 21





<210>  711

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  711

tgaaagttca gccatatgc                                                    19





<210>  712

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  712

catcacttga aagttcagcc a                                                 21





<210>  713

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  713

acatcacttg aaagttcagc c                                                 21





<210>  714

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  714

tcacttgaaa gttcagcca                                                    19





<210>  715

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  715

catcacttga aagttcagcc                                                   20





<210>  716

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  716

cacttgaaag ttcagccat                                                    19





<210>  717

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  717

gacatcactt gaaagttcag c                                                 21





<210>  718

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  718

atcacttgaa agttcagcc                                                    19





<210>  719

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  719

catcacttga aagttcagc                                                    19





<210>  720

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  720

gtacctcaca gaacatcagc                                                   20





<210>  721

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  721

tacctcacag aacatcagc                                                    19





<210>  722

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  722

gtacctcaca gaacatcag                                                    19





<210>  723

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  723

gtacctcaca gaacatcagc t                                                 21





<210>  724

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  724

gccatcagaa ctctaacatg c                                                 21





<210>  725

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  725

acctcacaga acatcagctt                                                   20





<210>  726

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  726

acctcacaga acatcagctt a                                                 21





<210>  727

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  727

tacctcacag aacatcagct t                                                 21





<210>  728

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  728

acctcacaga acatcagct                                                    19





<210>  729

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  729

cctcacagaa catcagctt                                                    19





<210>  730

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  730

gtttctcagg tgttcatgt                                                    19





<210>  731

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  731

gtcggtcata gtgagctagt t                                                 21





<210>  732

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  732

gtcggtcata gtgagctagt                                                   20





<210>  733

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  733

tgtcggtcat agtgagctag t                                                 21





<210>  734

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  734

ctgtcggtca tagtgagcta g                                                 21





<210>  735

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  735

ctgtcggtca tagtgagct                                                    19





<210>  736

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  736

actgtcggtc atagtgagct                                                   20





<210>  737

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  737

ctgtcggtca tagtgagcta                                                   20





<210>  738

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  738

actgtcggtc atagtgagct a                                                 21





<210>  739

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  739

tcggtcatag tgagctagtt t                                                 21





<210>  740

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  740

gtctcaacag caagtcatca g                                                 21





<210>  741

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  741

agtctcaaca gcaagtcatc a                                                 21





<210>  742

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  742

gtctcaacag caagtcatca                                                   20





<210>  743

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  743

cagccgaacg agattccatg t                                                 21





<210>  744

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  744

agtctcaaca gcaagtcatc                                                   20





<210>  745

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  745

ctcaacagca agtcatcagc c                                                 21





<210>  746

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  746

gtctcaacag caagtcatc                                                    19





<210>  747

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  747

agccgaacga gattccatgt                                                   20





<210>  748

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  748

cgagattcca tgtaagtca                                                    19





<210>  749

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  749

agccgaacga gattccatgt a                                                 21





<210>  750

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  750

gggcggtatt caactcatca c                                                 21





<210>  751

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  751

gggcggtatt caactcatca                                                   20





<210>  752

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  752

ggcggtattc aactcatcac t                                                 21





<210>  753

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  753

gggcggtatt caactcatc                                                    19





<210>  754

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  754

ggcggtattc aactcatcac                                                   20





<210>  755

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  755

gcggtattca actcatcact                                                   20





<210>  756

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  756

ggcggtattc aactcatca                                                    19





<210>  757

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  757

gcggtattca actcatcact g                                                 21





<210>  758

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  758

cggtattcaa ctcatcactg g                                                 21





<210>  759

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  759

ggtattcaac tcatcactgg                                                   20





<210>  760

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  760

tctccctgtc cttgttcctt                                                   20





<210>  761

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  761

tctccctgtc cttgttcct                                                    19





<210>  762

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  762

tctccctgtc cttgttcctt t                                                 21





<210>  763

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  763

ctccctgtcc ttgttccttt                                                   20





<210>  764

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  764

ctccctgtcc ttgttcctt                                                    19





<210>  765

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  765

ctccctgtcc ttgttccttt g                                                 21





<210>  766

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  766

atctccctgt ccttgttcct                                                   20





<210>  767

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  767

atctccctgt ccttgttcct t                                                 21





<210>  768

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  768

tccctgtcct tgttcctttg                                                   20





<210>  769

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  769

tccctgtcct tgttccttt                                                    19





<210>  770

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  770

gttctctgtc ccactctcg                                                    19





<210>  771

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  771

ctcggttctc tgtcccactc t                                                 21





<210>  772

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  772

tcctcaccag ccatcttccc                                                   20





<210>  773

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  773

tcggttctct gtcccactct c                                                 21





<210>  774

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  774

tctcggttct ctgtcccact c                                                 21





<210>  775

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  775

ctctgccacc tcctctttca c                                                 21





<210>  776

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  776

ctctgccacc tcctctttca                                                   20





<210>  777

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  777

tcctcaccag ccatcttccc a                                                 21





<210>  778

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  778

ctcctctctt tcctctgtct c                                                 21





<210>  779

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  779

ctctcctctc tttcctctgt c                                                 21





<210>  780

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  780

tcccacccat gcttagtacc c                                                 21





<210>  781

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  781

gagttcccac ccatgcttag t                                                 21





<210>  782

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  782

tcccacccat gcttagtacc                                                   20





<210>  783

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  783

agttcccacc catgcttagt                                                   20





<210>  784

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  784

ttcccaccca tgcttagtac c                                                 21





<210>  785

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  785

gagttcccac ccatgcttag                                                   20





<210>  786

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  786

gttcccaccc atgcttagt                                                    19





<210>  787

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  787

gttcccaccc atgcttagta c                                                 21





<210>  788

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  788

gttcccaccc atgcttagta                                                   20





<210>  789

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  789

cccacccatg cttagtaccc t                                                 21





<210>  790

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  790

ccctccttct cctgcttca                                                    19





<210>  791

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  791

actcactgcc tcccatcatc a                                                 21





<210>  792

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  792

actcactgcc tcccatcatc                                                   20





<210>  793

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  793

ccctccttct cctgcttcag                                                   20





<210>  794

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  794

actcactgcc tcccatcat                                                    19





<210>  795

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  795

ctcactgcct cccatcatca                                                   20





<210>  796

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  796

gactcactgc ctcccatcat c                                                 21





<210>  797

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  797

tccctttctt gtcatcacca                                                   20





<210>  798

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  798

ctcactgcct cccatcatc                                                    19





<210>  799

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  799

atccctttct tgtcatcacc a                                                 21





<210>  800

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  800

cttcccacac tcatcgcatt c                                                 21





<210>  801

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  801

cccttaccac actccacaca                                                   20





<210>  802

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  802

acccttacca cactccacac a                                                 21





<210>  803

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  803

acccttacca cactccacac                                                   20





<210>  804

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  804

tcccacactc atcgcattca                                                   20





<210>  805

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  805

ttcccacact catcgcattc a                                                 21





<210>  806

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  806

cccttaccac actccacac                                                    19





<210>  807

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  807

cttcccacac tcatcgcatt                                                   20





<210>  808

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  808

ttcccacact catcgcattc                                                   20





<210>  809

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  809

gcttcccaca ctcatcgcat                                                   20





<210>  810

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  810

gtctcctgcc acattcattc t                                                 21





<210>  811

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  811

gtctcctgcc acattcattc                                                   20





<210>  812

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  812

gtcaactcta atcctcccac t                                                 21





<210>  813

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  813

tcctgccaca ttcattctac c                                                 21





<210>  814

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  814

tctcctgcca cattcattct                                                   20





<210>  815

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  815

cctgccacat tcattctacc a                                                 21





<210>  816

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  816

tcaactctaa tcctcccact                                                   20





<210>  817

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  817

gtctcctgcc acattcatt                                                    19





<210>  818

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  818

cctgccacat tcattctacc                                                   20





<210>  819

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  819

tctcctgcca cattcattct a                                                 21





<210>  820

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  820

tcacccgtca cctcatccct                                                   20





<210>  821

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  821

ttcacccgtc acctcatccc t                                                 21





<210>  822

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  822

ttcacccgtc acctcatccc                                                   20





<210>  823

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  823

gcccttgtgc tctgcttctc                                                   20





<210>  824

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  824

gaccctcaga gccaccttt                                                    19





<210>  825

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  825

cccttgtgct ctgcttctcc t                                                 21





<210>  826

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  826

cccttgtgct ctgcttctcc                                                   20





<210>  827

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  827

gaccctcaga gccacctttg                                                   20





<210>  828

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  828

gcccttgtgc tctgcttct                                                    19





<210>  829

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  829

gtgcccttgt gctctgcttc t                                                 21





<210>  830

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  830

agttctctgc ctgccacca                                                    19





<210>  831

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  831

gttctctgcc tgccaccaag                                                   20





<210>  832

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  832

tctgatgtgt cctgtgcctc t                                                 21





<210>  833

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  833

agttctctgc ctgccaccaa g                                                 21





<210>  834

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  834

ctgatgtgtc ctgtgcctct                                                   20





<210>  835

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  835

agttctctgc ctgccaccaa                                                   20





<210>  836

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  836

gttctctgcc tgccaccaa                                                    19





<210>  837

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  837

gctcttcagt ctggcagggt                                                   20





<210>  838

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  838

ttctctgcct gccaccaagg                                                   20





<210>  839

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  839

ctgatgtgtc ctgtgcctct t                                                 21





<210>  840

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  840

tcctcctctt cctcctcctc t                                                 21





<210>  841

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  841

cctcctcttc ctcctcctct                                                   20





<210>  842

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  842

tcctcctctt cctcctcctc                                                   20





<210>  843

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  843

cctcctcttc ctcctcctct t                                                 21





<210>  844

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  844

cttcctcctc ttcctcctcc t                                                 21





<210>  845

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  845

cctcttcctc ctcttcctcc t                                                 21





<210>  846

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  846

ttcctcctct tcctcctcct c                                                 21





<210>  847

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  847

tcttcctcct cttcctcctc c                                                 21





<210>  848

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  848

tcctcttcct cctcttcctc c                                                 21





<210>  849

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  849

cttcctcctc ttcctcctcc                                                   20





<210>  850

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  850

gatgacttcc ctgctcccac                                                   20





<210>  851

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  851

atgacttccc tgctcccacg                                                   20





<210>  852

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  852

tgatgacttc cctgctccca c                                                 21





<210>  853

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  853

atgacttccc tgctcccac                                                    19





<210>  854

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  854

gtgatgactt ccctgctccc                                                   20





<210>  855

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  855

gtgatgactt ccctgctccc a                                                 21





<210>  856

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  856

gatgacttcc ctgctccca                                                    19





<210>  857

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  857

tgatgacttc cctgctccca                                                   20





<210>  858

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  858

tgatgacttc cctgctccc                                                    19





<210>  859

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  859

gctttctgcc ctccactcag                                                   20





<210>  860

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  860

ccattccgtc atctctccca                                                   20





<210>  861

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  861

ctcccagttc cagccttgca                                                   20





<210>  862

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  862

caccattccg tcatctctcc c                                                 21





<210>  863

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  863

ccaccattcc gtcatctctc c                                                 21





<210>  864

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  864

ccattccgtc atctctccc                                                    19





<210>  865

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  865

accattccgt catctctccc a                                                 21





<210>  866

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  866

accattccgt catctctccc                                                   20





<210>  867

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  867

tcccagttcc agccttgca                                                    19





<210>  868

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  868

ccattccgtc atctctccca a                                                 21





<210>  869

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  869

tccaccattc cgtcatctct c                                                 21





<210>  870

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  870

gccacatctt ctccagggtc t                                                 21





<210>  871

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  871

gccacatctt ctccagggtc                                                   20





<210>  872

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  872

gtttgtagca tccagtccca c                                                 21





<210>  873

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  873

agcagttctc tctccctct                                                    19





<210>  874

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  874

gccacatctt ctccagggt                                                    19





<210>  875

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  875

tttgtagcat ccagtcccac                                                   20





<210>  876

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  876

gcagttctct ctccctctga                                                   20





<210>  877

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  877

ttgtagcatc cagtcccac                                                    19





<210>  878

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  878

agcagttctc tctccctctg a                                                 21





<210>  879

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  879

agcagttctc tctccctctg                                                   20





<210>  880

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  880

tcttccttct tgttccactc a                                                 21





<210>  881

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  881

tcttccttct tgttccactc                                                   20





<210>  882

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  882

ttcttccttc ttgttccact c                                                 21





<210>  883

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  883

cttccttctt gttccactca                                                   20





<210>  884

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  884

gttcttcctt cttgttccac t                                                 21





<210>  885

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  885

cttccttctt gttccactc                                                    19





<210>  886

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  886

gccagccacc aggatatcga                                                   20





<210>  887

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  887

agcaccacct ccttgatcgg                                                   20





<210>  888

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  888

gttcttcctt cttgttccac                                                   20





<210>  889

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  889

ttccttcttg ttccactca                                                    19





<210>  890

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  890

ctcctcaatc cagccagtgt c                                                 21





<210>  891

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  891

gaccttccca gcccatttc                                                    19





<210>  892

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  892

gaccttccca gcccatttct                                                   20





<210>  893

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  893

tttcctgtgt gtgtcctttc                                                   20





<210>  894

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  894

accttcccag cccatttct                                                    19





<210>  895

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  895

ctcctcaatc cagccagtgt                                                   20





<210>  896

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  896

ttcctgtgtg tgtcctttc                                                    19





<210>  897

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  897

tcctcaatcc agccagtgtc                                                   20





<210>  898

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  898

tcctgtgtgt gtcctttcgc                                                   20





<210>  899

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  899

tctactcctc aatccagcca g                                                 21





<210>  900

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  900

gtccttcctc actacagccc                                                   20





<210>  901

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  901

gtccttcctc actacagccc a                                                 21





<210>  902

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  902

gccactgcta tgttctccca                                                   20





<210>  903

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  903

tccttccacc acactgcctt                                                   20





<210>  904

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  904

gccactgcta tgttctccca t                                                 21





<210>  905

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  905

gccactgcta tgttctccc                                                    19





<210>  906

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  906

atccttccac cacactgcct                                                   20





<210>  907

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  907

tccttccacc acactgcct                                                    19





<210>  908

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  908

tccttcctca ctacagccca                                                   20





<210>  909

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  909

tccttcctca ctacagccca g                                                 21





<210>  910

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  910

ttcccaccct cttccactcc                                                   20





<210>  911

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  911

cttcccaccc tcttccactc                                                   20





<210>  912

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  912

ccctcttcca ctcccaacct                                                   20





<210>  913

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  913

ttcccaccct cttccactc                                                    19





<210>  914

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  914

accctcttcc actcccaacc t                                                 21





<210>  915

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  915

ccaccctctt ccactcccaa                                                   20





<210>  916

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  916

cctcttccac tcccaacctc t                                                 21





<210>  917

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  917

accctcttcc actcccaacc                                                   20





<210>  918

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  918

cctcttccac tcccaacctc                                                   20





<210>  919

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  919

cttcccaccc tcttccact                                                    19





<210>  920

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  920

ccttctcttg tcctgccacc                                                   20





<210>  921

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  921

ccttctcttg tcctgccacc a                                                 21





<210>  922

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  922

cttctcttgt cctgccacca                                                   20





<210>  923

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  923

gccttctctt gtcctgccac                                                   20





<210>  924

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  924

cttctcttgt cctgccacc                                                    19





<210>  925

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  925

ccttctcttg tcctgccac                                                    19





<210>  926

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  926

tgccttctct tgtcctgcca c                                                 21





<210>  927

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  927

ttctcttgtc ctgccacca                                                    19





<210>  928

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  928

cttctcttgt cctgccacca c                                                 21





<210>  929

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  929

tctcttgtcc tgccaccact                                                   20





<210>  930

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  930

cctcttgtta gccctccacc t                                                 21





<210>  931

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  931

tcctcttgtt agccctccac c                                                 21





<210>  932

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  932

gtcctcctcc ttcagcccat                                                   20





<210>  933

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  933

cctcttgtta gccctccacc                                                   20





<210>  934

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  934

ctcttgttag ccctccacct c                                                 21





<210>  935

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  935

gtcctcctcc ttcagcccat t                                                 21





<210>  936

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  936

ctctttgtcc tcctccttc                                                    19





<210>  937

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  937

ttgtcctcct ccttcagccc                                                   20





<210>  938

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  938

gctctttgtc ctcctccttc                                                   20





<210>  939

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  939

ctcttgttag ccctccacct                                                   20





<210>  940

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  940

ctgctttccc ttctctgttg                                                   20





<210>  941

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  941

tcccttctct gttggttggc t                                                 21





<210>  942

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  942

ctgctttccc ttctctgtt                                                    19





<210>  943

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  943

ctgctttccc ttctctgttg g                                                 21





<210>  944

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  944

tcccttctct gttggttggc                                                   20





<210>  945

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  945

cccttctctg ttggttggct c                                                 21





<210>  946

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  946

ttcccttctc tgttggttgg c                                                 21





<210>  947

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  947

gctttccctt ctctgttggt                                                   20





<210>  948

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  948

gctttccctt ctctgttggt t                                                 21





<210>  949

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  949

tctctgttgg ttggctcttc t                                                 21





<210>  950

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  950

gcgtctccac atcccagttt                                                   20





<210>  951

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  951

gcgtctccac atcccagtt                                                    19





<210>  952

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  952

gttcgtgcgg tccctgtagt                                                   20





<210>  953

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  953

accagcgtct ccacatccca                                                   20





<210>  954

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  954

gttcgtgcgg tccctgtagt t                                                 21





<210>  955

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  955

cagcgtctcc acatcccagt                                                   20





<210>  956

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  956

tgttcgtgcg gtccctgtag t                                                 21





<210>  957

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  957

cgtctccaca tcccagttt                                                    19





<210>  958

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  958

cagcgtctcc acatcccagt t                                                 21





<210>  959

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  959

taccagcgtc tccacatccc a                                                 21





<210>  960

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  960

gtcttcctgc cgtttctctg t                                                 21





<210>  961

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  961

gtcttcctgc cgtttctctg                                                   20





<210>  962

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  962

gtcttcctgc cgtttctct                                                    19





<210>  963

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  963

tcttcctgcc gtttctctgt                                                   20





<210>  964

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  964

gatcgtcctt agccagtcca                                                   20





<210>  965

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  965

tcttcctgcc gtttctctgt t                                                 21





<210>  966

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  966

gggtcttcct gccgtttctc t                                                 21





<210>  967

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  967

atcgtcctta gccagtcca                                                    19





<210>  968

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  968

gtccttagcc agtccaatct c                                                 21





<210>  969

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  969

cttcctgccg tttctctgtt                                                   20





<210>  970

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  970

ctttcacctc cctctctcca                                                   20





<210>  971

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  971

ctttcacctc cctctctcc                                                    19





<210>  972

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  972

gctttcacct ccctctctcc                                                   20





<210>  973

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  973

gctttcacct ccctctctcc a                                                 21





<210>  974

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  974

tttcacctcc ctctctcca                                                    19





<210>  975

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  975

ccatctcact cactcactcc c                                                 21





<210>  976

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  976

ctttcacctc cctctctcca g                                                 21





<210>  977

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  977

tcactcactc ccagcatccc                                                   20





<210>  978

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  978

gttcccacac agcatctccc                                                   20





<210>  979

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  979

gttcccacac agcatctccc a                                                 21





<210>  980

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  980

gatgtcgtcc ctctctgtga                                                   20





<210>  981

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  981

gatgtcgtcc ctctctgtg                                                    19





<210>  982

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  982

atgtcgtccc tctctgtga                                                    19





<210>  983

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  983

gctgcccttg tactccatct                                                   20





<210>  984

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  984

ctgcccttgt actccatctt                                                   20





<210>  985

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  985

ctgcccttgt actccatctt g                                                 21





<210>  986

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  986

ctgctgccct tgtactccat c                                                 21





<210>  987

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  987

ctgcccttgt actccatct                                                    19





<210>  988

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  988

gctgcccttg tactccatct t                                                 21





<210>  989

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  989

gggcttgtcc accagtgagt                                                   20





<210>  990

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  990

cccaaccctg tgctctctga                                                   20





<210>  991

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  991

cccaaccctg tgctctctga a                                                 21





<210>  992

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  992

ccaaccctgt gctctctga                                                    19





<210>  993

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  993

ggatggttgc cgtgtctgtg t                                                 21





<210>  994

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  994

ccaaccctgt gctctctgaa                                                   20





<210>  995

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  995

gttgatctgt gaccttaccc                                                   20





<210>  996

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  996

gatggttgcc gtgtctgtgt                                                   20





<210>  997

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  997

ggttgccgtg tctgtgtaga                                                   20





<210>  998

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  998

tgttgatctg tgaccttacc c                                                 21





<210>  999

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  999

ggatggttgc cgtgtctgtg                                                   20





<210>  1000

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1000

ctcagcatgt tccctctcct c                                                 21





<210>  1001

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1001

tctcagcatg ttccctctcc t                                                 21





<210>  1002

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1002

ccgctctccc agtcatcaca                                                   20





<210>  1003

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1003

ctcagcatgt tccctctcct                                                   20





<210>  1004

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1004

tcagcatgtt ccctctcctc                                                   20





<210>  1005

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1005

tctcagcatg ttccctctcc                                                   20





<210>  1006

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1006

tcagcatgtt ccctctcctc a                                                 21





<210>  1007

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1007

ttctcagcat gttccctctc c                                                 21





<210>  1008

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1008

cagcatgttc cctctcctca                                                   20





<210>  1009

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1009

gctctcccag tcatcacagt c                                                 21





<210>  1010

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1010

tcctcttcac cacaccctcc t                                                 21





<210>  1011

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1011

ccacctgctc ctctcccatt                                                   20





<210>  1012

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1012

cctcttcacc acaccctcct                                                   20





<210>  1013

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1013

cctcctcttc accacaccct                                                   20





<210>  1014

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1014

tcctcttcac cacaccctcc                                                   20





<210>  1015

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1015

ctcctcctcc tcctgttcct                                                   20





<210>  1016

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1016

ctcctcctcc tcctcctgtt                                                   20





<210>  1017

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1017

tcctcctcct cctgttcctc                                                   20





<210>  1018

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1018

tcctcctcct cctcctgttc                                                   20





<210>  1019

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1019

ccacctgctc ctctcccatt t                                                 21





<210>  1020

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1020

atactcctca ccacctcct                                                    19





<210>  1021

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1021

atactcctca ccacctcctg                                                   20





<210>  1022

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1022

tactcctcac cacctcctg                                                    19





<210>  1023

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1023

gatactcctc accacctcct                                                   20





<210>  1024

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1024

gatactcctc accacctcct g                                                 21





<210>  1025

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1025

actcctcacc acctcctgt                                                    19





<210>  1026

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1026

tactcctcac cacctcctgt                                                   20





<210>  1027

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1027

gatactcctc accacctcc                                                    19





<210>  1028

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1028

atactcctca ccacctcctg t                                                 21





<210>  1029

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1029

agatactcct caccacctcc t                                                 21





<210>  1030

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1030

gttccacctt cttgttctcc c                                                 21





<210>  1031

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1031

ttccaagtcc cgcagccaca                                                   20





<210>  1032

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1032

tttccaagtc ccgcagccac a                                                 21





<210>  1033

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1033

tttccaagtc ccgcagccac                                                   20





<210>  1034

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1034

atttccaagt cccgcagcca c                                                 21





<210>  1035

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1035

ttccaccttc ttgttctccc                                                   20





<210>  1036

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1036

tccaccttct tgttctcccg                                                   20





<210>  1037

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1037

tccaccttct tgttctccc                                                    19





<210>  1038

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1038

ttccaccttc ttgttctccc g                                                 21





<210>  1039

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1039

tccaagtccc gcagccacaa                                                   20





<210>  1040

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1040

cttgccactg aagaactact g                                                 21





<210>  1041

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1041

gcagagggca acagttcttc a                                                 21





<210>  1042

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1042

ggcagagggc aacagttctt c                                                 21





<210>  1043

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1043

gcttgccact gaagaactac t                                                 21





<210>  1044

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1044

cttgccactg aagaactact                                                   20





<210>  1045

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1045

gctttagctg ggtcaggaca                                                   20





<210>  1046

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1046

gcagagggca acagttcttc                                                   20





<210>  1047

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1047

gctttagctg ggtcaggaca t                                                 21





<210>  1048

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1048

ctttagctgg gtcaggacat                                                   20





<210>  1049

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1049

ctttagctgg gtcaggaca                                                    19





<210>  1050

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1050

gctcatccac ttcctcatct                                                   20





<210>  1051

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1051

gctcatccac ttcctcatct g                                                 21





<210>  1052

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1052

atcacaccac cctgctaccc                                                   20





<210>  1053

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1053

cttggtcttg gtctttgttc t                                                 21





<210>  1054

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1054

cttcttggtc ttggtctttg t                                                 21





<210>  1055

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1055

tcacaccacc ctgctaccca                                                   20





<210>  1056

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1056

tcttggtctt ggtctttgtt c                                                 21





<210>  1057

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1057

gctcatccac ttcctcatc                                                    19





<210>  1058

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1058

ctcatccact tcctcatctg                                                   20





<210>  1059

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1059

atcacaccac cctgctaccc a                                                 21





<210>  1060

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1060

cctcatctcc ttcttcttcc c                                                 21





<210>  1061

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1061

ctcatctcct tcttcttccc                                                   20





<210>  1062

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1062

gtcccttgtg tttctgcttc t                                                 21





<210>  1063

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1063

gtcccttgtg tttctgcttc                                                   20





<210>  1064

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1064

cgtcccttgt gtttctgctt c                                                 21





<210>  1065

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1065

tcatctcctt cttcttccc                                                    19





<210>  1066

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1066

cccttcctca tccgcttctt c                                                 21





<210>  1067

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1067

tcctcatctc cttcttcttc c                                                 21





<210>  1068

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1068

cctcatctcc ttcttcttcc                                                   20





<210>  1069

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1069

cgtcccttgt gtttctgctt                                                   20





<210>  1070

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1070

tcttcacagc cctcttccac c                                                 21





<210>  1071

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1071

cttcacagcc ctcttccacc                                                   20





<210>  1072

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1072

cttcacagcc ctcttccacc a                                                 21





<210>  1073

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1073

tcacagccct cttccaccag                                                   20





<210>  1074

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1074

ttcacagccc tcttccacca                                                   20





<210>  1075

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1075

ttcacagccc tcttccacca g                                                 21





<210>  1076

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1076

tcacagccct cttccacca                                                    19





<210>  1077

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1077

tcttcacagc cctcttccac                                                   20





<210>  1078

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1078

ttcacagccc tcttccacc                                                    19





<210>  1079

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1079

atcttcacag ccctcttcca c                                                 21





<210>  1080

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1080

tcctcttact cccgccatct                                                   20





<210>  1081

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1081

ttcctcttac tcccgccatc t                                                 21





<210>  1082

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1082

ttcctcttac tcccgccatc                                                   20





<210>  1083

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1083

tcctcttact cccgccatct a                                                 21





<210>  1084

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1084

cctcttactc ccgccatct                                                    19





<210>  1085

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1085

tcctcttact cccgccatc                                                    19





<210>  1086

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1086

tttcctctta ctcccgccat c                                                 21





<210>  1087

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1087

cctcttactc ccgccatcta                                                   20





<210>  1088

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1088

tttcctctta ctcccgccat                                                   20





<210>  1089

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1089

tttcctctta ctcccgcca                                                    19





<210>  1090

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1090

ccgctgcttc cctgtactca                                                   20





<210>  1091

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1091

gctgcttccc tgtactcaca                                                   20





<210>  1092

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1092

cgctgcttcc ctgtactcac a                                                 21





<210>  1093

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1093

cgctgcttcc ctgtactcac                                                   20





<210>  1094

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1094

gctgcttccc tgtactcac                                                    19





<210>  1095

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1095

cgctgcttcc ctgtactca                                                    19





<210>  1096

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1096

ctccgtcgcc tctctttgct                                                   20





<210>  1097

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1097

ctctgtctct acttcgcttc c                                                 21





<210>  1098

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1098

ccgtcgcctc tctttgcttc t                                                 21





<210>  1099

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1099

ctccgtcgcc tctctttgct t                                                 21





<210>  1100

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1100

aaaccctcca ccctctctcc                                                   20





<210>  1101

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1101

actctgtccc tccctcaatc c                                                 21





<210>  1102

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1102

ctctgtccct ccctcaatcc                                                   20





<210>  1103

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1103

tctgtccctc cctcaatccc                                                   20





<210>  1104

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1104

aaaccctcca ccctctctc                                                    19





<210>  1105

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1105

cactctgtcc ctccctcaat c                                                 21





<210>  1106

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1106

actctgtccc tccctcaatc                                                   20





<210>  1107

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1107

tctcctcagc accctctcca                                                   20





<210>  1108

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1108

cactctgtcc ctccctcaat                                                   20





<210>  1109

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1109

ttctcctcag caccctctcc                                                   20





<210>  1110

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1110

cattcgcttc ttcctccact                                                   20





<210>  1111

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1111

cattcgcttc ttcctccact t                                                 21





<210>  1112

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1112

ttcgcttctt cctccacttg                                                   20





<210>  1113

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1113

cctctgcctc atctttcttc t                                                 21





<210>  1114

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1114

attcgcttct tcctccactt                                                   20





<210>  1115

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1115

attcgcttct tcctccactt g                                                 21





<210>  1116

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1116

tcgcttcttc ctccacttg                                                    19





<210>  1117

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1117

ttcgcttctt cctccactt                                                    19





<210>  1118

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1118

attcgcttct tcctccact                                                    19





<210>  1119

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1119

cctctgcctc atctttcttc                                                   20





<210>  1120

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1120

gccattctca tccaccttat                                                   20





<210>  1121

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1121

ttgccattct catccacctt                                                   20





<210>  1122

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1122

tttgccattc tcatccacct                                                   20





<210>  1123

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1123

gccattctca tccacctta                                                    19





<210>  1124

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1124

tttgccattc tcatccacct t                                                 21





<210>  1125

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1125

tgccattctc atccacctt                                                    19





<210>  1126

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1126

ttgccattct catccacct                                                    19





<210>  1127

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1127

gccattctca tccaccttat a                                                 21





<210>  1128

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1128

tgccattctc atccacctta                                                   20





<210>  1129

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1129

ttgccattct catccacctt a                                                 21





<210>  1130

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1130

ctccctctca ttgtccagtc c                                                 21





<210>  1131

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1131

ggtctggctc tctctctctc                                                   20





<210>  1132

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1132

tccctctcat tgtccagtcc                                                   20





<210>  1133

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1133

tccctctcat tgtccagtcc a                                                 21





<210>  1134

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1134

ccctctcatt gtccagtcca c                                                 21





<210>  1135

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1135

tctccctctc attgtccagt c                                                 21





<210>  1136

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1136

ggtctggctc tctctctctc a                                                 21





<210>  1137

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1137

ctccctctca ttgtccagtc                                                   20





<210>  1138

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1138

tctccctctc attgtccagt                                                   20





<210>  1139

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1139

ggtctggctc tctctctct                                                    19





<210>  1140

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1140

aaaccctcca ccctctctcc                                                   20





<210>  1141

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1141

actctgtccc tccctcaatc c                                                 21





<210>  1142

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1142

ctctgtccct ccctcaatcc                                                   20





<210>  1143

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1143

tctgtccctc cctcaatccc                                                   20





<210>  1144

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1144

aaaccctcca ccctctctc                                                    19





<210>  1145

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1145

ctctctctgc tgtcttcctc c                                                 21





<210>  1146

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1146

cactctgtcc ctccctcaat c                                                 21





<210>  1147

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1147

actctgtccc tccctcaatc                                                   20





<210>  1148

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1148

tctcctcagc accctctcca                                                   20





<210>  1149

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1149

tctctctgct gtcttcctcc                                                   20





<210>  1150

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1150

ccctacgcca cttggacaga                                                   20





<210>  1151

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1151

cctgcatggt ttgtctccc                                                    19





<210>  1152

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1152

tacgccactt ggacagagcc                                                   20





<210>  1153

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1153

ctacgccact tggacagagc                                                   20





<210>  1154

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1154

cctacgccac ttggacagag                                                   20





<210>  1155

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1155

ggactctggg aagctgtagg a                                                 21





<210>  1156

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1156

cctacgccac ttggacaga                                                    19





<210>  1157

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1157

aggactctgg gaagctgtag g                                                 21





<210>  1158

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1158

ggactctggg aagctgtagg                                                   20





<210>  1159

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1159

tacgccactt ggacagagc                                                    19





<210>  1160

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1160

ctctctctct ccactctctc c                                                 21





<210>  1161

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1161

tctctctctc cactctctcc                                                   20





<210>  1162

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1162

tctctctctc tccactctct c                                                 21





<210>  1163

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1163

ctctctctct ccactctctc                                                   20





<210>  1164

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1164

ctctctctcc actctctcc                                                    19





<210>  1165

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1165

tctctctctc tccactctct                                                   20





<210>  1166

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1166

gtctctctct ctccactctc t                                                 21





<210>  1167

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1167

gcgtctctct ctctccactc t                                                 21





<210>  1168

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1168

ttcactccct gcctcctcct                                                   20





<210>  1169

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1169

ctctctctct ccactctct                                                    19





<210>  1170

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1170

ccacatccct ctcaatcacc t                                                 21





<210>  1171

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1171

gcacacatcc atccacatcc c                                                 21





<210>  1172

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1172

ccacatccct ctcaatcacc                                                   20





<210>  1173

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1173

accacatccc tctcaatcac c                                                 21





<210>  1174

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1174

tccctctcaa tcacctccag c                                                 21





<210>  1175

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1175

ccttgtccct tcttatccc                                                    19





<210>  1176

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1176

cacacatcca tccacatccc a                                                 21





<210>  1177

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1177

ccactaacca catccctctc a                                                 21





<210>  1178

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1178

cacacatcca tccacatccc                                                   20





<210>  1179

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1179

tccctctcaa tcacctcca                                                    19





<210>  1180

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1180

gttctagttc tctctctccc t                                                 21





<210>  1181

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1181

gttctagttc tctctctccc                                                   20





<210>  1182

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1182

tcgaacctcc acttcctccc                                                   20





<210>  1183

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1183

cttcttcttt cttctcgtcc c                                                 21





<210>  1184

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1184

tcttctttct tctcgtccct                                                   20





<210>  1185

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1185

tcttctttct tctcgtccct t                                                 21





<210>  1186

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1186

ttcttctttc ttctcgtccc t                                                 21





<210>  1187

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1187

tctagttctc tctctccctt                                                   20





<210>  1188

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1188

ttctagttct ctctctccct                                                   20





<210>  1189

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1189

cttctttctt ctcgtccctt                                                   20





<210>  1190

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1190

tctcctctgt cccttcccac t                                                 21





<210>  1191

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1191

ctcctctgtc ccttcccact                                                   20





<210>  1192

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1192

tctcctctgt cccttcccac                                                   20





<210>  1193

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1193

atctcctctg tcccttccca c                                                 21





<210>  1194

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1194

atctcctctg tcccttccc                                                    19





<210>  1195

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1195

tcctctgtcc cttcccact                                                    19





<210>  1196

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1196

tcctctgtcc cttcccactg                                                   20





<210>  1197

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1197

gatctcctct gtcccttccc                                                   20





<210>  1198

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1198

tctcctctgt cccttccca                                                    19





<210>  1199

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1199

gatctcctct gtcccttccc a                                                 21





<210>  1200

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1200

ctcctgctca tccttcctct                                                   20





<210>  1201

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1201

ctcctgctca tccttcctct g                                                 21





<210>  1202

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1202

gtcccgctgt ctcatttgtg                                                   20





<210>  1203

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1203

tcccgctcct gctcatcctt                                                   20





<210>  1204

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1204

tcctgctcat ccttcctctg                                                   20





<210>  1205

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1205

cgtcccgctg tctcatttgt                                                   20





<210>  1206

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1206

gtcccgctgt ctcatttgt                                                    19





<210>  1207

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1207

tcctgctcat ccttcctct                                                    19





<210>  1208

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1208

cgtcccgctg tctcatttgt g                                                 21





<210>  1209

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1209

gctcaccact ttctcgtcca c                                                 21





<210>  1210

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1210

gttacatact cgccacctct                                                   20





<210>  1211

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1211

gttacatact cgccacctct g                                                 21





<210>  1212

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1212

tccacctctc tgccaagttt                                                   20





<210>  1213

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1213

ttccacctct ctgccaagtt                                                   20





<210>  1214

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1214

tttccacctc tctgccaagt                                                   20





<210>  1215

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1215

tccacctctc tgccaagttt g                                                 21





<210>  1216

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1216

ttccacctct ctgccaagtt t                                                 21





<210>  1217

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1217

tttccacctc tctgccaagt t                                                 21





<210>  1218

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1218

tccacctctc tgccaagtt                                                    19





<210>  1219

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1219

ttccacctct ctgccaagt                                                    19





<210>  1220

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1220

gtccttacca ccatcgccct                                                   20





<210>  1221

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1221

gctgtactcc tccctgtga                                                    19





<210>  1222

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1222

tccttaccac catcgccct                                                    19





<210>  1223

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1223

gctgtactcc tccctgtgaa                                                   20





<210>  1224

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1224

tccttaccac catcgccctg t                                                 21





<210>  1225

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1225

ccttaccacc atcgccctgt                                                   20





<210>  1226

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1226

agctgtactc ctccctgtga                                                   20





<210>  1227

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1227

gctgtactcc tccctgtgaa t                                                 21





<210>  1228

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1228

ccttaccacc atcgccctgt t                                                 21





<210>  1229

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1229

accaccatcg ccctgtttct                                                   20





<210>  1230

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1230

tcctgaccac ccacttccca                                                   20





<210>  1231

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1231

ccttctctcc tgaccaccca                                                   20





<210>  1232

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1232

tcctgaccac ccacttccca a                                                 21





<210>  1233

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1233

gtctccacct ccacatcgct                                                   20





<210>  1234

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1234

cctgaccacc cacttcccaa                                                   20





<210>  1235

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1235

cccacttccc aatctttcct                                                   20





<210>  1236

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1236

acccacttcc caatctttcc t                                                 21





<210>  1237

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1237

cccacttccc aatctttcct g                                                 21





<210>  1238

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1238

accacccact tcccaatct                                                    19





<210>  1239

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1239

cacccacttc ccaatctttc c                                                 21





<210>  1240

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1240

gccuggagau cuacaagaa                                                    19





<210>  1241

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1241

uccuugaugu caugcucaa                                                    19





<210>  1242

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1242

ggacgagaag cugaaggau                                                    19





<210>  1243

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1243

cccgaggauu gugcacuau                                                    19





<210>  1244

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1244

ccgaggauug ugcacuauu                                                    19





<210>  1245

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1245

gcgucuacgg augagcauu                                                    19





<210>  1246

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1246

gcaugagaag uuuaccauu                                                    19





<210>  1247

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1247

ccauggauau uucugcuau                                                    19





<210>  1248

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1248

gcaugcuuca uuuaccauu                                                    19





<210>  1249

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1249

ccucuacucc uucuucuuu                                                    19





<210>  1250

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1250

ggaaggcgau gacucagau                                                    19





<210>  1251

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1251

ggaagauucc agaagugaa                                                    19





<210>  1252

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1252

ccuccuucag acacgacaa                                                    19





<210>  1253

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1253

ccuucagaca cgacaagcu                                                    19





<210>  1254

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1254

ggcaguuucc guuugacuu                                                    19





<210>  1255

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1255

ggagguuccu agaguuguu                                                    19





<210>  1256

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1256

gcacaaucca aagagacaa                                                    19





<210>  1257

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1257

gcggagaucg augccauaa                                                    19





<210>  1258

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1258

gcagcaacau cuacccuuu                                                    19





<210>  1259

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1259

ccaaacaucu gguuggcaa                                                    19





<210>  1260

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1260

ugaccugcaa gacucacaa                                                    19





<210>  1261

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1261

gaccugcaag acucacaag                                                    19





<210>  1262

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1262

ccugcaagac ucacaagag                                                    19





<210>  1263

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1263

ugcugacaag aaagccgau                                                    19





<210>  1264

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1264

gcugacaaga aagccgaug                                                    19





<210>  1265

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1265

gggaugugcu ggaugugau                                                    19





<210>  1266

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1266

ggaugugaua ggccagguu                                                    19





<210>  1267

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1267

gcaaguaaau ggacaguua                                                    19





<210>  1268

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1268

ggaacauaca uggccugaa                                                    19





<210>  1269

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1269

gcccuccaau augcuagua                                                    19





<210>  1270

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1270

gcaucacaca gcagaucua                                                    19





<210>  1271

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1271

gcagauuucu gugccucau                                                    19





<210>  1272

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1272

gcuuguagau aaccucuaa                                                    19





<210>  1273

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1273

gcuccaagcc uggaaucuu                                                    19





<210>  1274

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1274

gccaccaucu caaucagua                                                    19





<210>  1275

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1275

gcaagcugcc gauaaguau                                                    19





<210>  1276

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1276

gcaaauucau ucgcaucaa                                                    19





<210>  1277

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1277

ggagccaaca uugagacuu                                                    19





<210>  1278

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1278

ccaugaggau uaugggcau                                                    19





<210>  1279

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1279

ccagaaggcg cagacuaaa                                                    19





<210>  1280

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1280

ggaguuacua gagucacua                                                    19





<210>  1281

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1281

gaguuacuag agucacuau                                                    19





<210>  1282

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1282

gucacuaucc ggaaaucua                                                    19





<210>  1283

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1283

ucacuauccg gaaaucuaa                                                    19





<210>  1284

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1284

gaagccaaga ucgaagauu                                                    19





<210>  1285

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1285

gccaggaaug uucgguuau                                                    19





<210>  1286

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1286

ggagagugcc cuuugcauu                                                    19





<210>  1287

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1287

ccuuaggaga agguggcuu                                                    19





<210>  1288

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1288

cccaguagcc cuauuccaa                                                    19





<210>  1289

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1289

gggaccgucu uucgauaua                                                    19





<210>  1290

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1290

gggcuaaagu gaccaugaa                                                    19





<210>  1291

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1291

ggcuaaagug accaugaau                                                    19





<210>  1292

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1292

ccuuggcaag ggaaccuuu                                                    19





<210>  1293

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1293

gcaagggaac cuuuggcaa                                                    19





<210>  1294

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1294

gcggaaggaa gucaucauu                                                    19





<210>  1295

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1295

gcaucagguc aacucucua                                                    19





<210>  1296

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1296

ccucaauucu guugaucuu                                                    19





<210>  1297

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1297

ccaagaguac agugaauuu                                                    19





<210>  1298

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1298

gcucuaacag ugcagauau                                                    19





<210>  1299

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1299

gcagauauaa cagguccuu                                                    19





<210>  1300

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1300

gaggcaagcu cagcaagaa                                                    19





<210>  1301

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1301

gaagaagaag ggcuacaau                                                    19





<210>  1302

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1302

gaagggcuac aaugugaac                                                    19





<210>  1303

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1303

gggcuacaau gugaacgac                                                    19





<210>  1304

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1304

ggcuacaaug ugaacgacg                                                    19





<210>  1305

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1305

gccuguaaga gugagacua                                                    19





<210>  1306

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1306

ccuguaagag ugagacuaa                                                    19





<210>  1307

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1307

gggccaacaa ugaguuguu                                                    19





<210>  1308

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1308

cccugcuuau gccaagcaa                                                    19





<210>  1309

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1309

gggaucuugu acucucuaa                                                    19





<210>  1310

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1310

ggaugaaaua gacucagaa                                                    19





<210>  1311

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1311

gcauguauga ugacagaaa                                                    19





<210>  1312

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1312

ccggauaaag cauggcaau                                                    19





<210>  1313

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1313

gcaaugacug ggcaacaau                                                    19





<210>  1314

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1314

gcgcuaggaa gaagugcau                                                    19





<210>  1315

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1315

ccacccgaau uggcagauu                                                    19





<210>  1316

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1316

gcaaagaucu caugggcuu                                                    19





<210>  1317

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1317

ccaagauacc augaaccau                                                    19





<210>  1318

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1318

gcauccagca ggauaucaa                                                    19





<210>  1319

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1319

gcugucagcc ugucagaau                                                    19





<210>  1320

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1320

gcaacuccaa uuaaacuca                                                    19





<210>  1321

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1321

ggaagcugug ugcccauua                                                    19





<210>  1322

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1322

gcccauuacc agcaaucag                                                    19





<210>  1323

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1323

gcccuucaau acuuucaag                                                    19





<210>  1324

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1324

gguugcggca agaacacua                                                    19





<210>  1325

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1325

gcggguacaa uuaaagaua                                                    19





<210>  1326

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1326

gcauguaaca cuccacuuu                                                    19





<210>  1327

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1327

ccuucaguau uuguaacuu                                                    19





<210>  1328

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1328

ccuggacucu accuaguaa                                                    19





<210>  1329

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1329

gcacgugacu ggacaauuu                                                    19





<210>  1330

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1330

cggcagcaug augaagaag                                                    19





<210>  1331

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1331

gccucaucau ccaguccaa                                                    19





<210>  1332

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1332

ccucaucauc caguccaac                                                    19





<210>  1333

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1333

cgagcucaca guuccucua                                                    19





<210>  1334

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1334

gagcucacag uuccucuac                                                    19





<210>  1335

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1335

gcuaaagaag guggaccua                                                    19





<210>  1336

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1336

gcgaugaauc agcagccaa                                                    19





<210>  1337

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1337

gcagccaaga agcccaaau                                                    19





<210>  1338

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1338

gcauuugcac acgauucaa                                                    19





<210>  1339

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1339

gcauaguaaa ugacaaaua                                                    19





<210>  1340

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1340

gccaggccuu caagaacau                                                    19





<210>  1341

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1341

ccagcaaguc guugguaaa                                                    19





<210>  1342

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1342

ccaguuccca aaguaacaa                                                    19





<210>  1343

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1343

ccaaaguaac aauaaucaa                                                    19





<210>  1344

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1344

gccacaaugu ccaagacuu                                                    19





<210>  1345

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1345

gcaacuacac aaauucaau                                                    19





<210>  1346

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1346

ggaggagucc ugacucaua                                                    19





<210>  1347

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1347

ggaguccuga cucauacuu                                                    19





<210>  1348

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1348

gaguccugac ucauacuuu                                                    19





<210>  1349

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1349

ccugacucau acuuucucu                                                    19





<210>  1350

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1350

gcaccaaggc gcaguauau                                                    19





<210>  1351

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1351

gcaguucugc cuugagcua                                                    19





<210>  1352

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1352

ccuugagcua aauggacuu                                                    19





<210>  1353

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1353

ccagauacuu gcacucaaa                                                    19





<210>  1354

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1354

gcugcauguc uucugaaua                                                    19





<210>  1355

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1355

gcuacgauuu cacacuauu                                                    19





<210>  1356

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1356

gcugcuuuau cucaguaua                                                    19





<210>  1357

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1357

ccauggaaau cucaguuau                                                    19





<210>  1358

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1358

gcagauccag cuuuauuaa                                                    19





<210>  1359

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1359

gcacauuggu gccuuucuu                                                    19





<210>  1360

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1360

gcaugagauu ucugaaauu                                                    19





<210>  1361

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1361

gcaggagaau aaugagaaa                                                    19





<210>  1362

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1362

gcucaugaaa ucaguuuaa                                                    19





<210>  1363

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1363

ggaaggaaau auaaagcaa                                                    19





<210>  1364

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1364

gcugauaugc cgagcauua                                                    19





<210>  1365

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1365

ucgccuacac cugguucaa                                                    19





<210>  1366

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1366

ccuacaccug guucaaccu                                                    19





<210>  1367

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1367

ucauggucau ccuguucaa                                                    19





<210>  1368

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1368

ucauccuguu caagggcau                                                    19





<210>  1369

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1369

gagcgagaug cagagcaaa                                                    19





<210>  1370

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1370

cucacugagu auuagccuu                                                    19





<210>  1371

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1371

gucucucgcu guggguauu                                                    19





<210>  1372

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1372

gcugugggua uucaccgaa                                                    19





<210>  1373

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1373

cuguggguau ucaccgaau                                                    19





<210>  1374

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1374

ggguauucac cgaaucucu                                                    19





<210>  1375

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1375

ggaucggcaa cuaaaccau                                                    19





<210>  1376

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1376

gcuguucaau cuacaauaa                                                    19





<210>  1377

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1377

ggcuuuacag agcaagaau                                                    19





<210>  1378

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1378

gcuuuacaga gcaagaauu                                                    19





<210>  1379

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1379

cccaaaguca gaccaacuu                                                    19





<210>  1380

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1380

ucuccagugu aaugauuau                                                    19





<210>  1381

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1381

gcaucaaucu gguggugac                                                    19





<210>  1382

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1382

gcaaucacau ugcucugua                                                    19





<210>  1383

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1383

gcacucagaa gggaaguua                                                    19





<210>  1384

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1384

gcgcaaguac aucucccuu                                                    19





<210>  1385

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1385

gcuucaaacg agucagaau                                                    19





<210>  1386

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1386

gcuccagcug cauaagacu                                                    19





<210>  1387

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1387

ccagcugcau aagacugag                                                    19





<210>  1388

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1388

gcugcauaag acugaguuu                                                    19





<210>  1389

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1389

gcauaagacu gaguuucug                                                    19





<210>  1390

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1390

gccaguaaag cugaaugaa                                                    19





<210>  1391

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1391

ccaguaaagc ugaaugaaa                                                    19





<210>  1392

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1392

gggaaggaaa ugugcccaa                                                    19





<210>  1393

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1393

ccacaagcau ucugugcuu                                                    19





<210>  1394

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1394

gcuucgcccu ugcuuguaa                                                    19





<210>  1395

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1395

cccagaaugc cgagaugau                                                    19





<210>  1396

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1396

ccuugugcug gguccaauu                                                    19





<210>  1397

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1397

gguucgggac auagagaau                                                    19





<210>  1398

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1398

gggacauaga gaaucugaa                                                    19





<210>  1399

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1399

gccuacucga auccaacaa                                                    19





<210>  1400

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1400

ggaaugggac aagacccau                                                    19





<210>  1401

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1401

ggacaagacc caucuuuau                                                    19





<210>  1402

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1402

ccagcaucuc auaaucuau                                                    19





<210>  1403

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1403

ccagggugaa uacagguau                                                    19





<210>  1404

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1404

gccucuaucu uacagagca                                                    19





<210>  1405

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1405

ugagcuccgu gaggauaaa                                                    19





<210>  1406

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1406

gagcuccgug aggauaaau                                                    19





<210>  1407

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1407

agcuccguga ggauaaaua                                                    19





<210>  1408

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1408

gcuccgugag gauaaauaa                                                    19





<210>  1409

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1409

uccgugagga uaaauaacu                                                    19





<210>  1410

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1410

acgaacugaa cucucucuu                                                    19





<210>  1411

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1411

cgaacugaac ucucucuuu                                                    19





<210>  1412

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1412

acugaacucu cucuuucug                                                    19





<210>  1413

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1413

ucaagugaug ucaucuuac                                                    19





<210>  1414

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1414

cagaugauuu gaauugaua                                                    19





<210>  1415

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1415

agaugauuug aauugauaa                                                    19





<210>  1416

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1416

gaugauuuga auugauaag                                                    19





<210>  1417

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1417

gaauugauaa gcugauguu                                                    19





<210>  1418

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1418

agcauguuag aguucugau                                                    19





<210>  1419

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1419

gcucacuaug accgacagu                                                    19





<210>  1420

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1420

ggaaucucgu ucggcugau                                                    19





<210>  1421

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1421

gaaucucguu cggcugaug                                                    19





<210>  1422

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1422

cucguucggc ugaugacuu                                                    19





<210>  1423

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1423

ucguucggcu gaugacuug                                                    19





<210>  1424

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1424

ccagugauga guugaauac                                                    19





<210>  1425

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1425

gucugaucaa ugugugacu                                                    19





<210>  1426

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1426

ucugaucaau gugugacug                                                    19





<210>  1427

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1427

ugaucaaugu gugacugaa                                                    19





<210>  1428

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1428

gaucaaugug ugacugaaa                                                    19





<210>  1429

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1429

ggacaagugu uauaccguu                                                    19





<210>  1430

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1430

gcaguuguug cagcucaaa                                                    19





<210>  1431

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1431

gcaacuuuac aaucaaaua                                                    19





<210>  1432

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1432

gcggaaggag uagaguuua                                                    19





<210>  1433

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1433

gcuuuccaag aaacaacua                                                    19





<210>  1434

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1434

gcuauagaag gcccuauua                                                    19





<210>  1435

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1435

ccgcucaaau uggcagaau                                                    19





<210>  1436

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1436

gcucaaauug gcagaauua                                                    19





<210>  1437

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1437

ccaggagcca uucuagaaa                                                    19





<210>  1438

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1438

ccgagugacu gcuuauaaa                                                    19





<210>  1439

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1439

gggagagacu gucaaagcu                                                    19





<210>  1440

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1440

gccgguaauu uggucaaca                                                    19





<210>  1441

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1441

gguaauuugg ucaacacuu                                                    19





<210>  1442

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1442

ggacacuugu ggaccgaau                                                    19





<210>  1443

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1443

gcuugccucu acuaccugu                                                    19





<210>  1444

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1444

ggagggucgu cucaaguau                                                    19





<210>  1445

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1445

gcuaagagau aucugcaau                                                    19





<210>  1446

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1446

ggagauuacu accguuacu                                                    19





<210>  1447

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1447

ggaaaugcaa ccaacacau                                                    19





<210>  1448

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1448

gcccuuaacu ucucugugu                                                    19





<210>  1449

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1449

ggucaucauu ccugagcaa                                                    19





<210>  1450

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1450

ccagcaggau gaugacaaa                                                    19





<210>  1451

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1451

ccagaagaug aagauuuaa                                                    19





<210>  1452

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1452

gcagcaaaug gaugacaau                                                    19





<210>  1453

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1453

gcagcagcuu augguaaua                                                    19





<210>  1454

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1454

ggucauccag cuuguccuu                                                    19





<210>  1455

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1455

gcuuguccuu uagucagua                                                    19





<210>  1456

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1456

ccuuuaguca guagaucua                                                    19





<210>  1457

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1457

ccagucuuuc aagaaguaa                                                    19





<210>  1458

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1458

gcaucuacaa agaaggcua                                                    19





<210>  1459

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1459

gccaccauca gguuuguca                                                    19





<210>  1460

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1460

ccaccaucag guuugucau                                                    19





<210>  1461

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1461

ccaucagguu ugucaugaa                                                    19





<210>  1462

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1462

gguuugucau gaagugcua                                                    19





<210>  1463

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1463

gcuccacuuc ccuuggaau                                                    19





<210>  1464

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1464

gcaauuggaa gcagcaaau                                                    19





<210>  1465

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1465

ccuugggagu cagacauuu                                                    19





<210>  1466

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1466

gcagcaccca agacucaaa                                                    19





<210>  1467

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1467

gcacccaaga cucaaacaa                                                    19





<210>  1468

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1468

gccauuggca aagcagcaa                                                    19





<210>  1469

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1469

gcaaggguuc ugggauaaa                                                    19





<210>  1470

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1470

gcacagaagc cuucuuuaa                                                    19





<210>  1471

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1471

ccauggauuc uguggcuuu                                                    19





<210>  1472

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1472

gccauaugau uuaucggaa                                                    19





<210>  1473

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1473

gggaugaauu uggcuucau                                                    19





<210>  1474

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1474

gcaguagaug cggaaguua                                                    19





<210>  1475

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1475

gcaagucaga uucugauau                                                    19





<210>  1476

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1476

gcuucaagau ugguggcuu                                                    19





<210>  1477

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1477

ccgagaagcu agaucuuaa                                                    19





<210>  1478

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1478

ccaaagacau uggacacuu                                                    19





<210>  1479

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1479

ggugguuauu ggagaucau                                                    19





<210>  1480

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1480

gcugcagcau cugagauua                                                    19





<210>  1481

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1481

gcgcuuauac agauuacua                                                    19





<210>  1482

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1482

ccaguacgca agugggaaa                                                    19





<210>  1483

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1483

gcaggaaaga gagaauuau                                                    19





<210>  1484

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1484

ccaguuacag ccuuaucuu                                                    19





<210>  1485

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1485

gcugugauuc ugagucaaa                                                    19





<210>  1486

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1486

ccucuuucac uccaucaaa                                                    19





<210>  1487

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1487

ccaucaaaga acucacuuu                                                    19





<210>  1488

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1488

gcuaagaaag ugcaguuaa                                                    19





<210>  1489

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1489

ccaacuguga ccgauuuaa                                                    19





<210>  1490

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1490

ccauaugcug gagagacau                                                    19





<210>  1491

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1491

ccuccuggaa uccuucaaa                                                    19





<210>  1492

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1492

ggugaaggaa cuugugcaa                                                    19





<210>  1493

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1493

ccguagauuu cagcaauau                                                    19





<210>  1494

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1494

ccuucucaag gauguaaau                                                    19





<210>  1495

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1495

ggugcaguac gugauucaa                                                    19





<210>  1496

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1496

gcacaggugu cguggaaua                                                    19





<210>  1497

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1497

ccagccaacu cucacauuu                                                    19





<210>  1498

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1498

ccguuuauca cuuuaccaa                                                    19





<210>  1499

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1499

gcaucagaag ccagugcua                                                    19





<210>  1500

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1500

ccuugaagcu guagccaaa                                                    19





<210>  1501

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1501

gcuaugcaga cacacucuu                                                    19





<210>  1502

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1502

gcagacacac ucuucgaua                                                    19





<210>  1503

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1503

gcauagauga uggugacaa                                                    19





<210>  1504

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1504

gcaggucuua aggagcuuu                                                    19





<210>  1505

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1505

ggagcgucuu ucucaggaa                                                    19





<210>  1506

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1506

gguggugcuu uaugucaaa                                                    19





<210>  1507

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1507

gcuacgacaa cauccauuu                                                    19





<210>  1508

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1508

ccauuucaug aaagccuuu                                                    19





<210>  1509

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1509

ggcaaguugg agagccuuu                                                    19





<210>  1510

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1510

gcaaguugga gagccuuug                                                    19





<210>  1511

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1511

uagagacacu ggcuggauu                                                    19





<210>  1512

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1512

gaaggcucaa acaacccaa                                                    19





<210>  1513

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1513

gcucaaacaa cccaaggcu                                                    19





<210>  1514

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1514

cucaaacaac ccaaggcuu                                                    19





<210>  1515

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1515

ucaaacaacc caaggcuuu                                                    19





<210>  1516

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1516

ggaaggaccu gcugaugaa                                                    19





<210>  1517

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1517

gcauaucacu gcauacaaa                                                    19





<210>  1518

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1518

ccuacagcuu ugguauauu                                                    19





<210>  1519

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1519

gcaguguagg gcagaguau                                                    19





<210>  1520

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1520

gcagcccauu ucaagacuu                                                    19





<210>  1521

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1521

ccuguugaug cagcucuaa                                                    19





<210>  1522

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1522

gccuggcuuu agcucagau                                                    19





<210>  1523

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1523

ccugcacaag aaagcuauu                                                    19





<210>  1524

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1524

gcacaagaaa gcuauucuu                                                    19





<210>  1525

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1525

gcaagaagug gcaaauaua                                                    19





<210>  1526

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1526

ggaucuuccu guaaaugau                                                    19





<210>  1527

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1527

ccauuggucc cucuugauu                                                    19





<210>  1528

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1528

gccagugagu guuaaugaa                                                    19





<210>  1529

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1529

cccugcauuu ggcugugaa                                                    19





<210>  1530

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1530

gcugugaacu acauugaua                                                    19





<210>  1531

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1531

gcuguuagcc ucaaaguuu                                                    19





<210>  1532

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1532

gcagaguuug uguacauua                                                    19





<210>  1533

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1533

gcagccugca aacugcaaa                                                    19





<210>  1534

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1534

gccugcaaac ugcaaaguu                                                    19





<210>  1535

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1535

gcaaacugca aaguugaaa                                                    19





<210>  1536

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1536

gcagcuacgu auccaucgu                                                    19





<210>  1537

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1537

gcuacguauc caucgugau                                                    19





<210>  1538

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1538

uccaucguga uggcaucua                                                    19





<210>  1539

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1539

ccaucgugau ggcaucuac                                                    19





<210>  1540

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1540

ugauggcauc uacauggua                                                    19





<210>  1541

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1541

ggcaucuaca ugguacaca                                                    19





<210>  1542

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1542

gcaucuacau gguacacau                                                    19





<210>  1543

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1543

cucagcuucc accaagguu                                                    19





<210>  1544

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1544

ucagcuucca ccaagguug                                                    19





<210>  1545

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1545

gccuucccga aacacugau                                                    19





<210>  1546

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1546

gcuugugugc uuagccuca                                                    19





<210>  1547

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1547

gccucauuuc caccaucua                                                    19





<210>  1548

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1548

ucauuuccac caucuacau                                                    19





<210>  1549

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1549

ucuacauggc agccuccau                                                    19





<210>  1550

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1550

ccuccauugg cacagacuu                                                    19





<210>  1551

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1551

gcaucuggga ugaauucau                                                    19





<210>  1552

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1552

ggauugugga gacggugua                                                    19





<210>  1553

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1553

gauuguggag acgguguau                                                    19





<210>  1554

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1554

ggagacggug uaucaccau                                                    19





<210>  1555

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1555

gcauugguau agcccacca                                                    19





<210>  1556

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1556

gcacgaacau gcaguuauu                                                    19





<210>  1557

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1557

ggagacacuc caccacaaa                                                    19





<210>  1558

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1558

cccucaccau uguguccau                                                    19





<210>  1559

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1559

ccucaccauu guguccauu                                                    19





<210>  1560

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1560

gaauauuacc accagagaa                                                    19





<210>  1561

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1561

ccaccagaga agagagcuu                                                    19





<210>  1562

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1562

gcauuuaucc uucauacca                                                    19





<210>  1563

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1563

gcaccugaua cucugucua                                                    19





<210>  1564

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1564

ccugauacuc ugucuaaau                                                    19





<210>  1565

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1565

gcacuuccug gaguuaaau                                                    19





<210>  1566

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1566

gauucuacca gaaaggaaug a                                                 21





<210>  1567

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1567

gagucacaau gcagacaaau a                                                 21





<210>  1568

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1568

gggagauugu ugcaaggaag a                                                 21





<210>  1569

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1569

ggcuagaaga gccaaccaac a                                                 21





<210>  1570

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1570

gaagggaaag cagucuguuc u                                                 21





<210>  1571

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1571

gaaagcaguc uguucugaac a                                                 21





<210>  1572

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1572

gcagucuguu cugaacauag g                                                 21





<210>  1573

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1573

gccaaguauc uuuccagcau g                                                 21





<210>  1574

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1574

gcauguuucu cccauuuaga a                                                 21





<210>  1575

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1575

gcauguaagg ccuuucaaua u                                                 21





<210>  1576

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1576

ggugagaacu gacuaaacua c                                                 21





<210>  1577

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1577

gcacagggau ugucaacauu c                                                 21





<210>  1578

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1578

gcuguugaga ccagcugaaa u                                                 21





<210>  1579

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1579

gagaccagcu gaaauguuug a                                                 21





<210>  1580

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1580

gaagcaacca agucuacaaa g                                                 21





<210>  1581

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1581

ggcacaguuu gacucaaaug g                                                 21





<210>  1582

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1582

ggauccaacu gauuagcaaa u                                                 21





<210>  1583

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1583

gcauagcagc uccaagucau c                                                 21





<210>  1584

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1584

gcuccaaguc aucccuaaug a                                                 21





<210>  1585

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1585

gacuuaaagu cauagccuuu g                                                 21





<210>  1586

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1586

gcaaugguac uguaauugag c                                                 21





<210>  1587

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1587

gguacuguaa uugagcaucc g                                                 21





<210>  1588

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1588

guaauugagc auccggaaua u                                                 21





<210>  1589

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1589

agggugacca acgcaagaac a                                                 21





<210>  1590

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1590

ggugaccaac gcaagaacau a                                                 21





<210>  1591

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1591

gugaccaacg caagaacaua u                                                 21





<210>  1592

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1592

gaccaacgca agaacauaug c                                                 21





<210>  1593

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1593

gcaagaacau augccaguuc c                                                 21





<210>  1594

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1594

gccaguuccu cguagagauu g                                                 21





<210>  1595

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1595

ggacgaucag cugaagguuc a                                                 21





<210>  1596

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1596

ggaguuccuc caguucuaug a                                                 21





<210>  1597

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1597

gcucauuggc aacuccuuac c                                                 21





<210>  1598

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1598

gcauccuuau gcgcgucacu a                                                 21





<210>  1599

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1599

ggcacugcaa caauggaauc c                                                 21





<210>  1600

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1600

gaacugacau ggaccaaauu a                                                 21





<210>  1601

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1601

gauccacaug cgggagcaaa u                                                 21





<210>  1602

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1602

gcaaauggac aaugccgugu a                                                 21





<210>  1603

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1603

gcgggugcug aagaaauacg a                                                 21





<210>  1604

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1604

gcugaagaaa uacgacuacg a                                                 21





<210>  1605

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1605

gcugaucuuc gaggacuuug c                                                 21





<210>  1606

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1606

gcugugacug caaggacuug u                                                 21





<210>  1607

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1607

gacugcaagg acuugucuua c                                                 21





<210>  1608

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1608

gcaaggacuu gucuuacaag g                                                 21





<210>  1609

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1609

gaaacucacu gguggacaag c                                                 21





<210>  1610

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1610

gcucuguaca gacugcuauu c                                                 21





<210>  1611

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1611

ggcaugagac cugcuucauc u                                                 21





<210>  1612

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1612

gcagccaauu ggaaccaaga g                                                 21





<210>  1613

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1613

ggcauaacga cugcuuuaac u                                                 21





<210>  1614

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1614

gcauaacgac ugcuuuaacu g                                                 21





<210>  1615

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1615

gcuuuaacug uaagaagugc u                                                 21





<210>  1616

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1616

ggacgaugag gaugaagaaa u                                                 21





<210>  1617

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1617

gacgaugagg augaagaaau g                                                 21





<210>  1618

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1618

gcugcaacau aaauuccagg a                                                 21





<210>  1619

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1619

gcaacauaaa uuccaggagc g                                                 21





<210>  1620

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1620

gcagcaggag cuauugcuga a                                                 21





<210>  1621

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1621

gcaggagcua uugcugaagu u                                                 21





<210>  1622

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1622

gcuauugcug aaguugcuac a                                                 21





<210>  1623

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1623

gacucauaca gccaccuauc g                                                 21





<210>  1624

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1624

gcuggaagcc aaagaauuug c                                                 21





<210>  1625

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1625

gccaaagaau uugccaaaca a                                                 21





<210>  1626

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1626

ggguggaauu gaugaagaaa u                                                 21





<210>  1627

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1627

gcucauacgu uagcgcuaaa u                                                 21





<210>  1628

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1628

gcaucagagu acccagaaau a                                                 21





<210>  1629

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1629

gcuugugguu acuaucauuc a                                                 21





<210>  1630

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1630

gcugcuuaag ucuuugcuug g                                                 21





<210>  1631

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1631

gcagaucugg acagugaaug a                                                 21





<210>  1632

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1632

gccaaugaga uagauggaac g                                                 21





<210>  1633

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1633

gcagauaucc cuguuacaau c                                                 21





<210>  1634

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1634

gcucaucaug agggaauuau u                                                 21





<210>  1635

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1635

ggagaagcau gcaacaguua c                                                 21





<210>  1636

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1636

gguggacagg uuccuguauc a                                                 21





<210>  1637

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1637

ggaguuccuu ucccuggauc u                                                 21





<210>  1638

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1638

gcacagagcu guuugaauau g                                                 21





<210>  1639

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1639

gcugacuguc uggcagauuu c                                                 21





<210>  1640

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1640

ggaagagggu guccuacuuu c                                                 21





<210>  1641

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1641

gcgaaguugg ugucaucauc g                                                 21





<210>  1642

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1642

gcugccaugg agaaguauaa a                                                 21





<210>  1643

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1643

gcacaaggug gugaggaaac u                                                 21





<210>  1644

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1644

ggucagugcg aauguacaac a                                                 21





<210>  1645

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1645

gcagcaacau gugcuacaug g                                                 21





<210>  1646

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1646

gauugaucag aacagagaug g                                                 21





<210>  1647

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1647

gaucagaaca gagaugguuu c                                                 21





<210>  1648

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1648

gagaugguuu caucgacaag g                                                 21





<210>  1649

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1649

gguuucaucg acaaggaaga u                                                 21





<210>  1650

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1650

aggaagauuu gcaugauaug c                                                 21





<210>  1651

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1651

gcaugauaug cuugcuucau u                                                 21





<210>  1652

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1652

ggaagaaucc aacugaugag u                                                 21





<210>  1653

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1653

gaauccaacu gaugaguauc u                                                 21





<210>  1654

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1654

guucacacgc auccugaaac a                                                 21





<210>  1655

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1655

ggagccaaag acaaagauga c                                                 21





<210>  1656

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1656

ggaaguaugc uguucucuau c                                                 21





<210>  1657

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1657

gaaguaugcu guucucuauc a                                                 21





<210>  1658

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1658

gccucuauuu gauaagcgau u                                                 21





<210>  1659

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1659

gaugagauuu cggaggaauu g                                                 21





<210>  1660

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1660

gauuucggag gaauugaaag a                                                 21





<210>  1661

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1661

gcugaagcua uccuugcugc a                                                 21





<210>  1662

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1662

gcuauccuug cugcagacuu c                                                 21





<210>  1663

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1663

gcugcagacu ucgaaauugg u                                                 21





<210>  1664

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1664

gagcguauaa ucccaagauc a                                                 21





<210>  1665

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1665

gcguauaauc ccaagaucag u                                                 21





<210>  1666

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1666

gcaggagaau guguuccuuc c                                                 21





<210>  1667

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1667

gcugacgugg ugccuauuaa c                                                 21





<210>  1668

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1668

ggagacauga auggcacuuu c                                                 21





<210>  1669

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1669

gcaauagcag ugauggcuuu g                                                 21





<210>  1670

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1670

gguccaauua ccaggauaaa u                                                 21





<210>  1671

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1671

ggugguucag ucaaaccaaa g                                                 21





<210>  1672

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1672

ggaacaacga acuccaguug c                                                 21





<210>  1673

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1673

gcuccacagu accacuuaaa g                                                 21





<210>  1674

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1674

ggucgauuca gagaagcauc c                                                 21





<210>  1675

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1675

gcaccagcag ugacaacuuc a                                                 21





<210>  1676

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1676

gcagagguuc caagaccaa                                                    19





<210>  1677

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1677

gggccugauu acauuccaa                                                    19





<210>  1678

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1678

gguucagauc ugugccuuu                                                    19





<210>  1679

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1679

gccuuuggcu gcaacaagu                                                    19





<210>  1680

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1680

gguuccaucc cuaaacuua                                                    19





<210>  1681

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1681

gcuuguauca ugggauacu                                                    19





<210>  1682

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1682

ggacaagcac gacgaucuu                                                    19





<210>  1683

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1683

gcagcagaca acauagaaa                                                    19





<210>  1684

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1684

ccaauuccau ucaguucuu                                                    19





<210>  1685

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1685

gaucccaacc uugaagaaa                                                    19





<210>  1686

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1686

ggugaccgaa cuagcaguu                                                    19





<210>  1687

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1687

gcaguugccc agugaucuu                                                    19





<210>  1688

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1688

gcaguuauug gucuuacau                                                    19





<210>  1689

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1689

ggcagauaca cuuaaugaa                                                    19





<210>  1690

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1690

gcggucauua cacaugcua                                                    19





<210>  1691

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1691

ggucauuaca caugcuauu                                                    19





<210>  1692

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1692

gcuauugaug cuugcuuua                                                    19





<210>  1693

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1693

gcauggacuc gaaagcaaa                                                    19





<210>  1694

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1694

ggacucgaaa gcaaauauu                                                    19





<210>  1695

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1695

ggaaagaacu ucaggaaau                                                    19





<210>  1696

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1696

ggcucauuca ccaccguaa                                                    19





<210>  1697

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1697

gcucauucac caccguaaa                                                    19





<210>  1698

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1698

gcaccuugga agaguguua                                                    19





<210>  1699

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1699

gccuaggaag cgaacuuau                                                    19





<210>  1700

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1700

gcgaacuuau gaacagaua                                                    19





<210>  1701

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1701

gcagauuaca auggcagau                                                    19





<210>  1702

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1702

gcagauuggc ggcagaaau                                                    19





<210>  1703

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1703

ggcggcagaa auagaugau                                                    19





<210>  1704

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1704

gcggcagaaa uagaugaua                                                    19





<210>  1705

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1705

gcaacucacu cgaauguua                                                    19





<210>  1706

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1706

uccaguggaa uacacccuu                                                    19





<210>  1707

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1707

ccaguggaau acacccuua                                                    19





<210>  1708

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1708

gcgugcucug agaucuaca                                                    19





<210>  1709

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1709

gcucugagau cuacauuca                                                    19





<210>  1710

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1710

ucaaccgcgc caucaacau                                                    19





<210>  1711

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1711

gcuuguugau gagcuggag                                                    19





<210>  1712

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1712

uccgcaacaa cucagccau                                                    19





<210>  1713

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1713

gcaacaacuc agccaucca                                                    19





<210>  1714

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1714

ccauccacau ccgagucuu                                                    19





<210>  1715

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1715

ucuucagggu cacacccaa                                                    19





<210>  1716

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1716

gcggagaaca auugaggau                                                    19





<210>  1717

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1717

ggagaacaau ugaggauuu                                                    19





<210>  1718

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1718

ggcauaugcu gguuacauu                                                    19





<210>  1719

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1719

gcucaaggac ucucucuuu                                                    19





<210>  1720

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1720

ucucccaucc uccucgaaa                                                    19





<210>  1721

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1721

cccauccucc ucgaaagaa                                                    19





<210>  1722

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1722

ccucgaaaga aggaccgaa                                                    19





<210>  1723

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1723

ccucuccugu gcuaagauu                                                    19





<210>  1724

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1724

ucuccugugc uaagauuaa                                                    19





<210>  1725

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1725

gccagaaaug caaggaacu                                                    19





<210>  1726

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1726

ccuuguagag ccaagcaaa                                                    19





<210>  1727

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1727

gccaggaagc uauuuccaa                                                    19





<210>  1728

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1728

ccaggaagcu auuuccaaa                                                    19





<210>  1729

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1729

ggaagcuauu uccaaagaa                                                    19





<210>  1730

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1730

gcuauuucca aagaaccua                                                    19





<210>  1731

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1731

gcagcuuacc gauguccuu                                                    19





<210>  1732

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1732

gccuuugacu gagagugaa                                                    19





<210>  1733

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1733

ggauaggacu auucuugau                                                    19





<210>  1734

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1734

gguagcacau gacauacau                                                    19





<210>  1735

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1735

ccuaagcaau ggcuaacuu                                                    19





<210>  1736

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1736

gcugcaucuc uccuacaau                                                    19





<210>  1737

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1737

gcaaagaaca guggucaau                                                    19





<210>  1738

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1738

gcacgcuuag auuggaaua                                                    19





<210>  1739

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1739

ggauuucgau gucagacuu                                                    19





<210>  1740

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1740

gcaccaaagu accuacuau                                                    19





<210>  1741

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1741

gcacuaccuu cuuugacua                                                    19





<210>  1742

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1742

ggucgacauc cacaccuaa                                                    19





<210>  1743

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1743

ccucguggac agagagauu                                                    19





<210>  1744

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1744

ggaaauagaa gccagugaa                                                    19





<210>  1745

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1745

gggaauggac uauuugcau                                                    19





<210>  1746

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1746

gaaagaaagc gaaguagaa                                                    19





<210>  1747

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1747

ucaagaaguc gagaucgaa                                                    19





<210>  1748

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1748

gguugccuca uagcaucaa                                                    19





<210>  1749

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1749

gccucauagc aucaaauua                                                    19





<210>  1750

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1750

gcaucaaauu aagcagacg                                                    19





<210>  1751

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1751

gcagcaaugg caaacaauu                                                    19





<210>  1752

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1752

gcuggaccua ugaggcuuu                                                    19





<210>  1753

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1753

ggcuuuaugu gggcucauu                                                    19





<210>  1754

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1754

gcuuuaugug ggcucauua                                                    19





<210>  1755

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1755

gcucauuaca cuucaacau                                                    19





<210>  1756

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1756

gcuccuuccg ggacaauaa                                                    19





<210>  1757

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1757

gggacaauaa cggugugau                                                    19





<210>  1758

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1758

ggacaauaac ggugugauu                                                    19





<210>  1759

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1759

ccucaggaaa cgaccacuu                                                    19





<210>  1760

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1760

gccgugugcc ugaguuauu                                                    19





<210>  1761

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1761

ccgugugccu gaguuauuu                                                    19





<210>  1762

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1762

gcacagaauc uugcuucau                                                    19





<210>  1763

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1763

ccuaacaucc uucaagaau                                                    19





<210>  1764

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1764

gccagcauac agucuuauu                                                    19





<210>  1765

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1765

ccagcauaca gucuuauua                                                    19





<210>  1766

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1766

agucuuacac cacucccaa                                                    19





<210>  1767

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1767

gucuuacacc acucccaag                                                    19





<210>  1768

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1768

caccacuccc aagaagaau                                                    19





<210>  1769

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1769

accacuccca agaagaaua                                                    19





<210>  1770

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1770

ccacucccaa gaagaauaa                                                    19





<210>  1771

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1771

ucccaagaag aauaagcac                                                    19





<210>  1772

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1772

cccaagaaga auaagcaca                                                    19





<210>  1773

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1773

ccaagaagaa uaagcacaa                                                    19





<210>  1774

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1774

gcacaagaga aagaagguu                                                    19





<210>  1775

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1775

cacaagagaa agaagguua                                                    19





<210>  1776

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1776

gccucugcuu cggaaucuu                                                    19





<210>  1777

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1777

ggaaucuuau gccuucauu                                                    19





<210>  1778

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1778

ccggcauggu ccaacaauu                                                    19





<210>  1779

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1779

ggagauguag uuucaagaa                                                    19





<210>  1780

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1780

ccuagagagu augguucuu                                                    19





<210>  1781

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1781

ccuucuggua ccugcaaau                                                    19





<210>  1782

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1782

gguaccugca aauccauau                                                    19





<210>  1783

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1783

ccauaucaua cugcagaaa                                                    19





<210>  1784

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1784

ccugacuggc uucagguuu                                                    19





<210>  1785

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1785

gcagugguau gcccaacaa                                                    19





<210>  1786

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1786

gcuccuuccg ggacaauaa                                                    19





<210>  1787

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1787

gggacaauaa cggugugau                                                    19





<210>  1788

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1788

ggacaauaac ggugugauu                                                    19





<210>  1789

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1789

ccucaggaaa cgaccacuu                                                    19





<210>  1790

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1790

gccgugugcc ugaguuauu                                                    19





<210>  1791

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1791

ccgugugccu gaguuauuu                                                    19





<210>  1792

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1792

gcacagaauc uugcuucau                                                    19





<210>  1793

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1793

ccuaacaucc uucaagaau                                                    19





<210>  1794

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1794

gccagcauac agucuuauu                                                    19





<210>  1795

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1795

ccagcauaca gucuuauua                                                    19





<210>  1796

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1796

uccacaacgu uggaaauaa                                                    19





<210>  1797

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1797

ccacaacguu ggaaauaaa                                                    19





<210>  1798

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1798

ggaaauaaag cugggccuc                                                    19





<210>  1799

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1799

gugucugcgc cugcauauu                                                    19





<210>  1800

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1800

gcgccugcau auuccuaca                                                    19





<210>  1801

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1801

ccugcauauu ccuacagcu                                                    19





<210>  1802

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1802

cugcauauuc cuacagcuu                                                    19





<210>  1803

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1803

uccuacagcu ucccagagu                                                    19





<210>  1804

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1804

ccagaguccu gucgacaau                                                    19





<210>  1805

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1805

agaguccugu cgacaauua                                                    19





<210>  1806

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1806

gguauggucu gguauucuu                                                    19





<210>  1807

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1807

gcuagcguuu guaaagcua                                                    19





<210>  1808

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1808

gcagguauua gaugaucaa                                                    19





<210>  1809

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1809

gcagauggaa auggaaaua                                                    19





<210>  1810

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1810

ccaaguguca cagucguaa                                                    19





<210>  1811

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1811

gcaguggaca aaucugcaa                                                    19





<210>  1812

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1812

gcugcuacag aaucuucua                                                    19





<210>  1813

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1813

gcgaaacaca aacaagaaa                                                    19





<210>  1814

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1814

ggaagugcau uaucaccuu                                                    19





<210>  1815

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1815

ccaagacacc agaugccaa                                                    19





<210>  1816

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1816

gggaugcccu gguaaucaa                                                    19





<210>  1817

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1817

ggaggugauu gagagggau                                                    19





<210>  1818

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1818

gguuaguggu uccgagguu                                                    19





<210>  1819

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1819

ccaauguacu cacgggauu                                                    19





<210>  1820

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1820

ggcuuugacu acuuacuaa                                                    19





<210>  1821

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1821

ggaugguuuc caguggcau                                                    19





<210>  1822

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1822

ccaguggcau gccagauuu                                                    19





<210>  1823

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1823

gcacauggcc acucugaaa                                                    19





<210>  1824

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1824

gccaagaaua uggagauua                                                    19





<210>  1825

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1825

gcucggauug aguaugcuu                                                    19





<210>  1826

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1826

gccucuggac aagaaugaa                                                    19





<210>  1827

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1827

gcagcucaug cggaugauu                                                    19





<210>  1828

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1828

gcucaugcgg augauuuau                                                    19





<210>  1829

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1829

gcggaugauu uauucccau                                                    19





<210>  1830

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1830

gcagcggaag auaauauuu                                                    19





<210>  1831

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1831

ggaaagacuu aucacgcaa                                                    19





<210>  1832

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1832

gcaauuggca ugggacuua                                                    19





<210>  1833

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1833

gcagcugguc uucauccaa                                                    19





<210>  1834

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1834

gcuaccgauu uauggauau                                                    19





<210>  1835

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1835

ccaaagcucu agggaguaa                                                    19





<210>  1836

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1836

ucaccacacc aacuucuaa                                                    19





<210>  1837

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1837

gccugccacu uucuagcau                                                    19





<210>  1838

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1838

gccacuuucu agcauccaa                                                    19





<210>  1839

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1839

ucuagcaucc aacagaauu                                                    19





<210>  1840

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1840

ggcccaacuc ccaucuaau                                                    19





<210>  1841

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1841

gcacacuccu aauugacaa                                                    19





<210>  1842

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1842

ccagagaagc uacgcucau                                                    19





<210>  1843

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1843

ccagucacgg auggagaaa                                                    19





<210>  1844

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1844

ggauggagaa auaugucau                                                    19





<210>  1845

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1845

ggaagccuuc cuucugcuu                                                    19





<210>  1846

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1846

gcuugcaaac agccaucca                                                    19





<210>  1847

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1847

gcaaacagcc auccaacaa                                                    19





<210>  1848

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1848

gggcuggaaa cauaugguu                                                    19





<210>  1849

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1849

ggcuggaaac auaugguuu                                                    19





<210>  1850

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1850

gcuggaaaca uaugguuug                                                    19





<210>  1851

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1851

gaagcacucc agcagcuau                                                    19





<210>  1852

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1852

gcacuccagc agcuauaau                                                    19





<210>  1853

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1853

gcuauaauca aggugguua                                                    19





<210>  1854

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1854

gguuacaacc aagacagcu                                                    19





<210>  1855

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1855

gccaaccuca gaugaguuu                                                    19





<210>  1856

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1856

gguuauaccg agaacuuaa                                                    19





<210>  1857

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1857

ccguguuacc uggaaccaa                                                    19





<210>  1858

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1858

gcaucgaugg cuggaguaa                                                    19





<210>  1859

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1859

gcuaacgcgg uccuguaaa                                                    19





<210>  1860

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1860

ccuguaaaga ugaaaccuu                                                    19





<210>  1861

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1861

gcaacaaagg cuacagaau                                                    19





<210>  1862

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1862

gcagcaaagu cucggucaa                                                    19





<210>  1863

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1863

ggagaugcag caacaggaa                                                    19





<210>  1864

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1864

gcaacaggaa cuggcacaa                                                    19





<210>  1865

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1865

gcucuacaaa gcauuccuu                                                    19





<210>  1866

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1866

acuggcucag uagugccuu                                                    19





<210>  1867

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1867

cuggcucagu agugccuuu                                                    19





<210>  1868

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1868

uagcuacauc ugguaccuu                                                    19





<210>  1869

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1869

gguaccuugg cuggcauua                                                    19





<210>  1870

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1870

guaccuuggc uggcauuau                                                    19





<210>  1871

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1871

uggcuggcau uaugggaau                                                    19





<210>  1872

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1872

ggcauuaugg gaaugaggu                                                    19





<210>  1873

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1873

gcauuauggg aaugagguu                                                    19





<210>  1874

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1874

gggaaugagg uucuaccac                                                    19





<210>  1875

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1875

ggaaugaggu ucuaccacu                                                    19





<210>  1876

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1876

ggcaauaguu ugggaugaa                                                    19





<210>  1877

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1877

gcaauaguuu gggaugaau                                                    19





<210>  1878

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1878

gcagcugaug ugaagaaua                                                    19





<210>  1879

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1879

ggaggaguac agcuuagau                                                    19





<210>  1880

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1880

gcuuagaucu cauuccauu                                                    19





<210>  1881

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1881

gcaagaaagc aaagaucau                                                    19





<210>  1882

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1882

ccguggaaca ggaguuuau                                                    19





<210>  1883

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1883

ccuccaaucc guguguaau                                                    19





<210>  1884

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1884

gcguaaccuu cgcugaaau                                                    19





<210>  1885

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1885

ggaagaugga gguacagaa                                                    19





<210>  1886

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1886

gaguguagcc gcccaaauu                                                    19





<210>  1887

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1887

cccuaucugc cgugacuuu                                                    19





<210>  1888

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1888

ggguagagga guuaaagaa                                                    19





<210>  1889

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1889

ggccaccaau gagguacua                                                    19





<210>  1890

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1890

gcaaucaggc caaggucau                                                    19





<210>  1891

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1891

uccagugucc cagcaagaa                                                    19





<210>  1892

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1892

cccuuggcag gaaucacaa                                                    19





<210>  1893

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1893

ccuuggcagg aaucacaau                                                    19





<210>  1894

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1894

ccacucccau ggugacuua                                                    19





<210>  1895

<211>  19

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1895

ccauggugac uuacccuau                                                    19





<210>  1896

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1896

aacaacuucu ccguagcaga a                                                 21





<210>  1897

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1897

aagguacuuc gaugaugaau u                                                 21





<210>  1898

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1898

acgggcuaaa gugaccauga a                                                 21





<210>  1899

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1899

caagcguggu gaauacauca a                                                 21





<210>  1900

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1900

ccggaguguu agaauaugcc a                                                 21





<210>  1901

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1901

acucgcugau ccaaaugaca a                                                 21





<210>  1902

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1902

caggccuaug gucgagauuu a                                                 21





<210>  1903

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1903

uugaccgaag aaccaauuau a                                                 21





<210>  1904

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1904

cacaguaauc uucacacuua a                                                 21





<210>  1905

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1905

ucggauaaag uccuuauuca a                                                 21





<210>  1906

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1906

cgggacgucc uuaaggaugu a                                                 21





<210>  1907

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1907

agccagauug ucagcccucu a                                                 21





<210>  1908

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1908

gaggauggaa acacccuucu a                                                 21





<210>  1909

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1909

cggcagcaug augaagaagg a                                                 21





<210>  1910

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1910

cccgccguug ucgcccaucg a                                                 21





<210>  1911

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1911

cgcggccggc agcaugauga a                                                 21





<210>  1912

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1912

guggauguug augguaguac a                                                 21





<210>  1913

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1913

aagacguucc ugaagcuugc c                                                 21





<210>  1914

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1914

cagaucuuag uaagcuauau a                                                 21





<210>  1915

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1915

ugggaaauag aagccaguga a                                                 21





<210>  1916

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1916

aaaggccagc accugaagaa u                                                 21





<210>  1917

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1917

aagacguaug uuggaacaaa u                                                 21





<210>  1918

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1918

caagacguau guuggaacaa a                                                 21





<210>  1919

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1919

aaggcaaugc ugucauauua u                                                 21





<210>  1920

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1920

gagguuaaag acagucauau a                                                 21





<210>  1921

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1921

cuccuaguac uuagaaauac a                                                 21





<210>  1922

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1922

uuggcuauac ugcaucacuu a                                                 21





<210>  1923

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1923

cuggacgauc cucucagugc a                                                 21





<210>  1924

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1924

caagccagga auguucgguu a                                                 21





<210>  1925

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1925

cccaguagcc cuauuccaag a                                                 21





<210>  1926

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1926

aagcggguag uagaucaugc a                                                 21





<210>  1927

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1927

caaccuauaa ugggugggua a                                                 21





<210>  1928

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1928

gaaguuauuc auauacgucu a                                                 21





<210>  1929

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1929

acccauaagg uuuaggauag a                                                 21





<210>  1930

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1930

cucaggagaa gcagagcaca a                                                 21





<210>  1931

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1931

aagacgcuug gcccagcuca a                                                 21





<210>  1932

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1932

agggaugagg ugacggguga a                                                 21





<210>  1933

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1933

cucgagguug caggacucuu u                                                 21





<210>  1934

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1934

cagcaaccaa uuaucaguuu a                                                 21





<210>  1935

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1935

uaggguuaga ggcgagauua a                                                 21





<210>  1936

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1936

cgccgccguc ccagauauua a                                                 21





<210>  1937

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1937

aaagaauaua ugcuaggguu a                                                 21





<210>  1938

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1938

uacaggaugu ugucccauca a                                                 21





<210>  1939

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1939

cacauggauc ucaaugccaa u                                                 21





<210>  1940

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1940

uuccaagauc cgcgucugaa a                                                 21





<210>  1941

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1941

ugggagaauc caaauaguau u                                                 21





<210>  1942

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1942

cagccuuauc uuagagguac a                                                 21





<210>  1943

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1943

uacauccaaa ccaguacgca a                                                 21





<210>  1944

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1944

ucagugcaag uuacaucuau a                                                 21





<210>  1945

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1945

uacuacaagg cuggaacuca a                                                 21





<210>  1946

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1946

ccgccucaug uuugaauacc a                                                 21





<210>  1947

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1947

aaggugcagu acgugauuca a                                                 21





<210>  1948

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1948

uagcgugguc cggaauggaa a                                                 21





<210>  1949

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1949

ugcccguaga uuucagcaau a                                                 21





<210>  1950

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1950

caggagcguc uuucucagga a                                                 21





<210>  1951

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1951

aaggaagcac auguugcuaa a                                                 21





<210>  1952

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1952

gagcgaagaa gcaauacuga a                                                 21





<210>  1953

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1953

uacaggcuca agauuagauu a                                                 21





<210>  1954

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1954

cagcauaaac aguaucucgg a                                                 21





<210>  1955

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1955

cggcgugcag guggugauug a                                                 21





<210>  1956

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1956

cgccuguaag agugagacua a                                                 21





<210>  1957

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1957

uuggagcggc ccagcagugu a                                                 21





<210>  1958

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1958

cuggcuggau ugaggaguag a                                                 21





<210>  1959

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1959

cuggaugaca guugggugau a                                                 21





<210>  1960

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1960

aaagacggaa ggcauacuaa a                                                 21





<210>  1961

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1961

uacgaauucu aucuuuggga a                                                 21





<210>  1962

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1962

aacgguuaga uuuaguuacc a                                                 21





<210>  1963

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1963

aaacggcgag auguagcuga a                                                 21





<210>  1964

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1964

uccucgaaga uucaaucuca a                                                 21





<210>  1965

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1965

augaccuguu gcagcuauua a                                                 21





<210>  1966

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1966

ccagcucaag agguuuggau a                                                 21





<210>  1967

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1967

cagacccuuu ggaccgacaa a                                                 21





<210>  1968

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1968

cucguggacu gguuaguuga a                                                 21





<210>  1969

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1969

accagagaca cuaaaucugu a                                                 21





<210>  1970

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1970

gccagcuguc aggauaauaa a                                                 21





<210>  1971

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1971

aaagcuggcc ugaaucauua a                                                 21





<210>  1972

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1972

cugcagcuga aucacacagg a                                                 21





<210>  1973

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1973

uacggaugag cauuuaguga a                                                 21





<210>  1974

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1974

aagcauggag auuucuucua u                                                 21





<210>  1975

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1975

cuggaaagau cagaauauua u                                                 21





<210>  1976

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1976

uuggauauga uacaaaucuu u                                                 21





<210>  1977

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1977

ccgggcgagg auuaguauua u                                                 21





<210>  1978

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1978

uucacauacc aggguuauua a                                                 21





<210>  1979

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1979

cuguuguaga uagccaguca a                                                 21





<210>  1980

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1980

cagggaaguu agucaaauga a                                                 21





<210>  1981

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1981

cacgaacaug caguuauuga a                                                 21





<210>  1982

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1982

cuggauaugu acuaacgaau a                                                 21





<210>  1983

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1983

uagcaguaca augauuagua a                                                 21





<210>  1984

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1984

cccgggauga acggauugaa a                                                 21





<210>  1985

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1985

auggaacacg gccacaucaa a                                                 21





<210>  1986

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1986

cgcagccgug cccaucguca a                                                 21





<210>  1987

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1987

cagggacucc uguuuacgac a                                                 21





<210>  1988

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1988

cagccagugu cuaaacucca a                                                 21





<210>  1989

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1989

aacaacggaa uguaucaaug a                                                 21





<210>  1990

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1990

uuagucuacg uuggagguaa a                                                 21





<210>  1991

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1991

auggauacac gugcauuuaa a                                                 21





<210>  1992

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1992

auggauccaa cugauuagca a                                                 21





<210>  1993

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1993

auggucccug ucagcaaaga a                                                 21





<210>  1994

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1994

aagaagcaac caagucuaca a                                                 21





<210>  1995

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1995

aacucuggcu ugcuaacuua a                                                 21





<210>  1996

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1996

augaacaaua uugaacgcua u                                                 21





<210>  1997

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1997

gucgauagug auauucaguc a                                                 21





<210>  1998

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1998

caggcaucug auguuauaga u                                                 21





<210>  1999

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  1999

uccguugucu agauuugagu a                                                 21





<210>  2000

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2000

gaccagacau auccuagcua a                                                 21





<210>  2001

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2001

aagcaauacc gucauguuuc a                                                 21





<210>  2002

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2002

agcuguagag cuugcaacuu a                                                 21





<210>  2003

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2003

cugcaugaug acagaagccg a                                                 21





<210>  2004

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2004

ccgacagucc aaggagcugu a                                                 21





<210>  2005

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2005

cgccguguac cacauggugu a                                                 21





<210>  2006

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2006

cagcacgucc guguucaagc a                                                 21





<210>  2007

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2007

aucgaguaag gcacacccaa a                                                 21





<210>  2008

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2008

cucccguugc gucaagucua a                                                 21





<210>  2009

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2009

acccuuuagu gcuuugugau a                                                 21





<210>  2010

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2010

aagguaauga ccaguuguua u                                                 21





<210>  2011

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2011

ucccgccuuu cuauuccaca a                                                 21





<210>  2012

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2012

caccgcccuu aauccauuua a                                                 21





<210>  2013

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2013

uucaagcauc uguuuaacaa a                                                 21





<210>  2014

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2014

auggaaacua ccuuaaacga a                                                 21





<210>  2015

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2015

augcguaggc uuaugucuaa a                                                 21





<210>  2016

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2016

acacgggaug uuauuauuau u                                                 21





<210>  2017

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2017

cuagcggaga ucgaugccau a                                                 21





<210>  2018

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2018

cuguccaugu cuuacuacuu u                                                 21





<210>  2019

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2019

uugggaugaa ucagaaaucu a                                                 21





<210>  2020

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2020

aagugccguu guucaguucu a                                                 21





<210>  2021

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2021

cucauuaguu ugggcaguau a                                                 21





<210>  2022

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2022

ucgggucggc ccauucgcaa a                                                 21





<210>  2023

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2023

uaccguuaug ggcgagagga a                                                 21





<210>  2024

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2024

cccuaugaug uccacgauua u                                                 21





<210>  2025

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2025

cggcgcaagu uugaauuuga u                                                 21





<210>  2026

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2026

uugcggcaag aacacuauuu a                                                 21





<210>  2027

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2027

uucaguuuau uuggauuauu a                                                 21





<210>  2028

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2028

cagcuauucu ucagcuuggu a                                                 21





<210>  2029

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2029

cagccgaaga cugaucgaca u                                                 21





<210>  2030

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2030

gagggaauua uuggauccua a                                                 21





<210>  2031

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2031

uagaaauacu acauagggua a                                                 21





<210>  2032

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2032

cagguugcuu gugguuacua u                                                 21





<210>  2033

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2033

uaggacagcu aggucaugaa a                                                 21





<210>  2034

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2034

cacacuaagg gcaagaucga a                                                 21





<210>  2035

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2035

cgggcuuaug ccaaagaugu a                                                 21





<210>  2036

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2036

aaggcuucga gaagauuagc a                                                 21





<210>  2037

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2037

caccaccaga ugagaaguua a                                                 21





<210>  2038

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2038

caggguuugg ugacaauaga a                                                 21





<210>  2039

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2039

acaguacgag aaaucauuga a                                                 21





<210>  2040

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2040

cuggcggcau uugauuguau u                                                 21





<210>  2041

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2041

aacucgugug auccaguguu a                                                 21





<210>  2042

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2042

agguccuauu guacuuacua a                                                 21





<210>  2043

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2043

cccagugagu uuggacgcaa a                                                 21





<210>  2044

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2044

uccaaggagc aucuuccgca a                                                 21





<210>  2045

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2045

auggcagcga agauaguuca a                                                 21





<210>  2046

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2046

cagagcugac cuguccggua a                                                 21





<210>  2047

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2047

caggguaucc cauccgugua a                                                 21





<210>  2048

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2048

ccacgggaau guaacaggua a                                                 21





<210>  2049

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2049

auagcggacc uguacacuua a                                                 21





<210>  2050

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2050

cacaaucgcu uugguuauga a                                                 21





<210>  2051

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2051

cacaauggua aggcacauaa a                                                 21





<210>  2052

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2052

ugccguagga uuuacagaau a                                                 21





<210>  2053

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2053

aaaggaauca ucuguagcga a                                                 21





<210>  2054

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2054

cagcaggguu agcauaaagg a                                                 21





<210>  2055

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2055

cgggacuuuc uauuaauauc a                                                 21





<210>  2056

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2056

aucuuuauaa ucagacugga a                                                 21





<210>  2057

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2057

uaacuucaaa uuccagccaa a                                                 21





<210>  2058

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2058

auaggauaau uuaaccuacc a                                                 21





<210>  2059

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2059

auggauugug gucucaguuu a                                                 21





<210>  2060

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2060

cacgagugug aacuagaauu a                                                 21





<210>  2061

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2061

caggucacug acauugucgu a                                                 21





<210>  2062

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2062

cucaguauag gcuucuagua a                                                 21





<210>  2063

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2063

ucggagcaca agcgcaagaa a                                                 21





<210>  2064

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2064

aaccgggacg aagccaucaa a                                                 21





<210>  2065

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2065

uccacugagc aucacaauaa a                                                 21





<210>  2066

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2066

caggagcagc uccaggcaga a                                                 21





<210>  2067

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2067

aagaaggcac ggaaggcuau g                                                 21





<210>  2068

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2068

cugcuucaca ggauccagaa a                                                 21





<210>  2069

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2069

aucgaagauu uaucccagca a                                                 21





<210>  2070

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2070

ugcgguuggu guccuggcaa a                                                 21





<210>  2071

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2071

cagacuguag agccacauuu a                                                 21





<210>  2072

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2072

auggcagaca uugacaacaa a                                                 21





<210>  2073

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2073

caccacgcuu ugauaacuaa a                                                 21





<210>  2074

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2074

ucgccgauau uuggaguucu u                                                 21





<210>  2075

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2075

aggcaauuca guggacuaua a                                                 21





<210>  2076

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2076

cccggugguu uccuagaaac a                                                 21





<210>  2077

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2077

accgcaguau uguccaaauu a                                                 21





<210>  2078

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2078

agggcccaac augaaggugu a                                                 21





<210>  2079

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2079

cagggcgucu uccuaaguua u                                                 21





<210>  2080

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2080

cccgcccguu ugggaggaga a                                                 21





<210>  2081

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2081

aucgggcucg auggaggaag a                                                 21





<210>  2082

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2082

cggcguguuc agcgucacug a                                                 21





<210>  2083

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2083

caacauaaca cuaauuauaa a                                                 21





<210>  2084

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2084

cccgaaauag cacaaaugaa a                                                 21





<210>  2085

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2085

aagacgggaa ugaugaggua a                                                 21





<210>  2086

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2086

cccggugguu cagucaaacc a                                                 21





<210>  2087

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2087

uuggcuguag ccacacggau a                                                 21





<210>  2088

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2088

uacauuggau cggcaacuaa a                                                 21





<210>  2089

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2089

caggacguuc caguucaaau u                                                 21





<210>  2090

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2090

aagccuguau caacucuggu a                                                 21





<210>  2091

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2091

auggcuauaa uauggcuaua a                                                 21





<210>  2092

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2092

caggacaagc acgacgaucu u                                                 21





<210>  2093

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2093

uaagcuaguu auaaucaugu a                                                 21





<210>  2094

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2094

cugcaacaag uauguugauu a                                                 21





<210>  2095

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2095

aagggugguc ucauaagauu a                                                 21





<210>  2096

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2096

accggcagau acacuuaaug a                                                 21





<210>  2097

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2097

cagucguaaa ucaaagagua a                                                 21





<210>  2098

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2098

cacccauuua ugacugccgu a                                                 21





<210>  2099

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2099

cagacucuag aucucguuag a                                                 21





<210>  2100

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2100

aggucgguaa uuuaacauaa a                                                 21





<210>  2101

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2101

cacucgaaug uuagcagauu u                                                 21





<210>  2102

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2102

augguaagcc uuagcagcaa a                                                 21





<210>  2103

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2103

aagauccacc uccgacccuu a                                                 21





<210>  2104

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2104

auggcggagc ccagucccga a                                                 21





<210>  2105

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2105

cagugcuacc uugcuugaga a                                                 21





<210>  2106

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2106

cucccgguac augagaauca a                                                 21





<210>  2107

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2107

caggucccua uuaucauaaa u                                                 21





<210>  2108

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2108

uucgugcuca acagcaaaga a                                                 21





<210>  2109

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2109

cucagaaggg aaguuaccua a                                                 21





<210>  2110

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2110

cuguaacuau ugccauauaa a                                                 21





<210>  2111

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2111

ccgcaacaac ucagccaucc a                                                 21





<210>  2112

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2112

auccagugga auacacccuu a                                                 21





<210>  2113

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2113

acccaaugac auuuauguca a                                                 21





<210>  2114

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2114

cucgguuuga uuugauacua a                                                 21





<210>  2115

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2115

aggacuauuc uugauaagaa a                                                 21





<210>  2116

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2116

cuggauagga cuauucuuga u                                                 21





<210>  2117

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2117

cagccuaauu gagcccuauu a                                                 21





<210>  2118

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2118

cagcagcaau cucuucccga a                                                 21





<210>  2119

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2119

agagaaccua uugauaauuu a                                                 21





<210>  2120

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2120

ccugaagaug uuuaaacgug a                                                 21





<210>  2121

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2121

uaccguaaca auguuuguca u                                                 21





<210>  2122

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2122

aaggacauca ccuuucagua u                                                 21





<210>  2123

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2123

aagcauguca aguggauagu a                                                 21





<210>  2124

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2124

gugggagacu aagauguauu a                                                 21





<210>  2125

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2125

uacagucuua uuagucaagg a                                                 21





<210>  2126

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2126

ccagaaccua acauccuuca a                                                 21





<210>  2127

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2127

aacgauccuc cacuugacca a                                                 21





<210>  2128

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2128

cgggacaaua acggugugau u                                                 21





<210>  2129

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2129

cuagaggucu uugcaaggga a                                                 21





<210>  2130

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2130

uacacugaug acggccuaga a                                                 21





<210>  2131

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2131

aaacuggagu uuaucaagga a                                                 21





<210>  2132

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2132

caggaaccgg caagaccaca a                                                 21





<210>  2133

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2133

uucgaaucau cugauauuua u                                                 21





<210>  2134

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2134

aaggguuuag auguagauuc u                                                 21





<210>  2135

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2135

aaguacguau ugacagaauu a                                                 21





<210>  2136

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2136

acgaaucucg cgagaaguca a                                                 21





<210>  2137

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2137

gccgagugua acaaccauau a                                                 21





<210>  2138

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2138

cucaauggau cuagaacuuc a                                                 21





<210>  2139

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2139

gagacccacc uugcucauaa a                                                 21





<210>  2140

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2140

cuggacuauu ucuguguuua u                                                 21





<210>  2141

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2141

cugacuuacu guuucaacaa a                                                 21





<210>  2142

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2142

cugcggugga gccgccacca a                                                 21





<210>  2143

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2143

gacaaguaac uguaugaguu a                                                 21





<210>  2144

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2144

ucgagguuga acccucggau a                                                 21





<210>  2145

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2145

aaccaugguu cugaagauuu a                                                 21





<210>  2146

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2146

aacgaguuga gucauccgaa u                                                 21





<210>  2147

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2147

auuggugaua cuucuaaacu a                                                 21





<210>  2148

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2148

cagacugggu uaagcuacca a                                                 21





<210>  2149

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2149

aauccugagc cuacucgaau c                                                 21





<210>  2150

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2150

cagauccuga gccuacucga a                                                 21





<210>  2151

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2151

cagccugaca uggacccacu a                                                 21





<210>  2152

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2152

cagucucuug caaucggcua a                                                 21





<210>  2153

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2153

cagcguuaca guaauguucc a                                                 21





<210>  2154

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2154

gagagguacu acuaaccaau a                                                 21





<210>  2155

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2155

aaggccauag cuuuaagaga u                                                 21





<210>  2156

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2156

acagagcagc uuguugcuau a                                                 21





<210>  2157

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2157

aaggauucca aguaacucuu a                                                 21





<210>  2158

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2158

aucagagauc ccaggguuaa a                                                 21





<210>  2159

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2159

ccgggcacuu cguaagguuu a                                                 21





<210>  2160

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2160

uuggagaaau uucacaguac a                                                 21





<210>  2161

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2161

caacguggau acacccuggg a                                                 21





<210>  2162

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2162

cugcgccugc auauuccuac a                                                 21





<210>  2163

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2163

uuccacaacg uuggaaauaa a                                                 21





<210>  2164

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2164

ccagaguccu gucgacaauu a                                                 21





<210>  2165

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2165

cccagagccu guaaagguga a                                                 21





<210>  2166

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2166

ugaaccacug ggacuggcug g                                                 21





<210>  2167

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2167

uucacauguc uuacucucug u                                                 21





<210>  2168

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2168

aagauuuguu ccagaaggaa c                                                 21





<210>  2169

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2169

gagcuccgug aggauaaaua a                                                 21





<210>  2170

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2170

uucacagacc uguacugagc u                                                 21





<210>  2171

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2171

uacugagcuc cgugaggaua a                                                 21





<210>  2172

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2172

uccgugagga uaaauaacuc u                                                 21





<210>  2173

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2173

uacgaacuga acucucucuu u                                                 21





<210>  2174

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2174

uucugaugga uuaguggaga a                                                 21





<210>  2175

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2175

ucugauggau uaguggagaa a                                                 21





<210>  2176

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2176

cgaacugaac ucucucuuuc u                                                 21





<210>  2177

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2177

ucaagugaug ucaucuuacu a                                                 21





<210>  2178

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2178

auggcugaac uuucaaguga u                                                 21





<210>  2179

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2179

gacaagcaua uggcugaacu u                                                 21





<210>  2180

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2180

gucaucuuac uacugagaag u                                                 21





<210>  2181

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2181

uugaauugau aagcugaugu u                                                 21





<210>  2182

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2182

ucagaugauu ugaauugaua a                                                 21





<210>  2183

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2183

auagcauguu agaguucuga u                                                 21





<210>  2184

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2184

aagcugaugu ucugugaggu a                                                 21





<210>  2185

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2185

cucacuauga ccgacaguga a                                                 21





<210>  2186

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2186

augaaucaaa cuagcucacu a                                                 21





<210>  2187

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2187

aauacaugaa caccugagaa a                                                 21





<210>  2188

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2188

augaugaauc aaacuagcuc a                                                 21





<210>  2189

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2189

uuugugauga cuuacaugga a                                                 21





<210>  2190

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2190

cuugcuguug agacucugaa a                                                 21





<210>  2191

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2191

ggcugaugac uugcuguuga g                                                 21





<210>  2192

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2192

auggaaucuc guucggcuga u                                                 21





<210>  2193

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2193

cccagucuga ucaaugugug a                                                 21





<210>  2194

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2194

caccagugau gaguugaaua c                                                 21





<210>  2195

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2195

cugaucaaug ugugacugaa a                                                 21





<210>  2196

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2196

ucugaucaau gugugacuga a                                                 21





<210>  2197

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2197

uacgaucagg auuacuauag a                                                 21





<210>  2198

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2198

cccguggaua ugguucaacu u                                                 21





<210>  2199

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2199

cagaacugcc uuugcacuaa a                                                 21





<210>  2200

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2200

cccgaucacg ccgcaagcga a                                                 21





<210>  2201

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2201

cagaucaaca aagaugacgu a                                                 21





<210>  2202

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2202

uacacugaug uucuucacua a                                                 21





<210>  2203

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2203

augcugauac agcaccauga a                                                 21





<210>  2204

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2204

aagaccguca auaagauacu a                                                 21





<210>  2205

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2205

uccgagguuc uucacugggu a                                                 21





<210>  2206

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2206

cuccgcguca uuguuggaag a                                                 21





<210>  2207

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2207

cagccagucc ucugagcgaa a                                                 21





<210>  2208

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2208

aggaguugca gagaucuauu a                                                 21





<210>  2209

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2209

cacgauuguc aggaaccuua a                                                 21





<210>  2210

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2210

ugggacuuaa uuugagcaua a                                                 21





<210>  2211

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2211

auggccuuua cuuccaccua a                                                 21





<210>  2212

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2212

cuggcacaug agaucuucga a                                                 21





<210>  2213

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2213

cugccacuuu cuagcaucca a                                                 21





<210>  2214

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2214

accacuggug guuuaucuaa a                                                 21





<210>  2215

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2215

cuggcgcgaa acaucaucaa u                                                 21





<210>  2216

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2216

cuaguggugu cagcagauca a                                                 21





<210>  2217

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2217

cagcccuguu augucaagcu u                                                 21





<210>  2218

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2218

gagcucucua gucuucauua a                                                 21





<210>  2219

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2219

uagcguuugc cuacccauuc a                                                 21





<210>  2220

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2220

ugcgugauua gugauguugg a                                                 21





<210>  2221

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2221

cagguuauac cgagaacuua a                                                 21





<210>  2222

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2222

cgggacgaug augacauuaa u                                                 21





<210>  2223

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2223

cccguccaga ucuccaccgu a                                                 21





<210>  2224

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2224

cgcgguccug uaaagaugaa a                                                 21





<210>  2225

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2225

cgcaagcuuu gccgagaucu a                                                 21





<210>  2226

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2226

aacgcuuuac uaaauaccua a                                                 21





<210>  2227

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2227

acgaguugaa ucauuguuca a                                                 21





<210>  2228

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2228

cccguucuuc cuccaaccau a                                                 21





<210>  2229

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2229

ucagucauga uuacaaaccu a                                                 21





<210>  2230

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2230

gagcuuaaua agacccucau a                                                 21





<210>  2231

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2231

uaggagauuu acaauaucug u                                                 21





<210>  2232

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2232

uggcgaguau guaacacaag a                                                 21





<210>  2233

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2233

cccuugagag acaguuucga a                                                 21





<210>  2234

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2234

cacaggagga auuggauuca a                                                 21





<210>  2235

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2235

caggacacuu guggaccgaa u                                                 21





<210>  2236

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2236

caccagggac auggaguccg a                                                 21





<210>  2237

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2237

acggcuauga gcacauauug a                                                 21





<210>  2238

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2238

uaguuuggga ugaauaccua a                                                 21





<210>  2239

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2239

cagcuuagau cucauuccau u                                                 21





<210>  2240

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2240

auggagguac agaauauguc a                                                 21





<210>  2241

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2241

cagguuuaug uuacuucuau u                                                 21





<210>  2242

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2242

cagcacgcua auaaugcaau u                                                 21





<210>  2243

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2243

augggcucuu accaaguuua a                                                 21





<210>  2244

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2244

caaggcugug guagaaucau a                                                 21





<210>  2245

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2245

caccaaugag guacuacugg a                                                 21





<210>  2246

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2246

uugagucaua ugaauauagu u                                                 21





<210>  2247

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2247

gacgucauga ucucuaugau a                                                 21





<210>  2248

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2248

cugauaggag ccuucagaca a                                                 21





<210>  2249

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2249

cagaacguuu guagagauau u                                                 21





<210>  2250

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2250

cagagaacgg gugcuaauua u                                                 21





<210>  2251

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2251

gaggacguug uuauagaaga u                                                 21





<210>  2252

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2252

uaggucugaa ucagugucau a                                                 21





<210>  2253

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2253

cagcuugucc uuuagucagu a                                                 21





<210>  2254

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2254

gcacguguuc uggauguaua a                                                 21





<210>  2255

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2255

cuaaguuguu guuuaggcua a                                                 21





<210>  2256

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2256

caggaaucac cuucaagccu a                                                 21





<210>  2257

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2257

uucugcuacg gagaaguugu u                                                 21





<210>  2258

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2258

aauucaucau cgaaguaccu u                                                 21





<210>  2259

<211>  21

<212>  RNA

<213>  Artificial Sequence



<220>

<223>  Synthetic construct



<400>  2259

uucaugguca cuuuagcccg u                                                 21





