                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       New York University
       Schneerson, Rachel
       Kubler-Kielb, Joanna
       Robbins, John B
       Majadly, Fathy
       Mocca, Christopher P
       Keith, Jerry
       Biesova, Zuzana
       Miller, Louis
       Nussenzweig, Ruth
       Liu, Darrell
 
<120>  A MULTICOMPONENT VACCINE FOR MALARIA PROVIDING LONG-LASTING 
       IMMUNE RESPONSES AGAINST PLASMODIA

<130>  4239-81941-03

<150>  US 61/101,944
<151>  2008-10-01

<150>  61/112,572
<151>  2008-11-07

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Asn Ala Asn Pro 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asn Pro Asn Ala 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Pro Asn Ala Asn 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Asn Pro Asn 
1               


<210>  5
<211>  982
<212>  DNA
<213>  Plasmodium falciparum

<400>  5
gagatatcct gttccaggaa tatcaatgct acggatccag cagcaacacg cgtgttctga       60

acgaactgaa ctacgataac gctggtacca atctgtacaa cgaactggaa atgaactact      120

acggtaaaca ggaaaactgg tacagcctga aaaaaaacag cagatctcta ggcgaaaacg      180

acgacggcaa caacaacaac ggtgataacg gtcgcgaagg taaagacgaa gacaaacgcg      240

acggcaacaa cgaagacaac gaaaaacttc gcaaaccgaa acacaaaaaa cttaagcagc      300

caggggatgg taatccagat ccgaacgcga atccgaacgt agacccgaac gcaaacccga      360

acgtagaccc gaacgcaaac ccgaacgtag acccgaacgc gaatccgaac gcgaacccta      420

acgcgaaccc gaacgcgaac ccgaacgcga acccgaacgc gaacccgaac gcgaacccga      480

acgcgaaccc gaacgcgaac ccgaacgcga acccgaacgc gaacccgaac gcgaacccga      540

acgcgaaccc gaacgcgaac ccgaacgcga acccgaacgc gaacccgaac gcgaacccga      600

acgcgaaccc gaacgcgaac ccgaacgcga acccgaacgc gaacccgaac aaaaacaatc      660

agggtaatgg ccagggtcac aatatgccaa atgacccaaa ccgaaatgta gatgaaaatg      720

ctaatgccaa caatgctgta aaaaataata ataacgaaga accaagtgat aagcacatag      780

aacaatattt aaagaaaata caaaattctc tttcaactga atggtcccca tgtagtgtaa      840

cttgcggcaa cggtattcag gtgcgcatca agccgggctc tgctaacaaa cctaaggacg      900

aactggatta cgaaaacgat atcgaaaaaa agatctgtaa gatggaacac catcatcatc      960

accattaatg agcggccgca ct                                               982


<210>  6
<211>  321
<212>  PRT
<213>  Plasmodium falciparum

<400>  6

Met Gly Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr 
1               5                   10                  15      


Arg Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr 
            20                  25                  30          


Asn Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser 
        35                  40                  45              


Leu Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn 
    50                  55                  60                  


Asn Asn Gly Asp Asn Gly Arg Glu Gly Lys Asp Glu Asp Lys Arg Asp 
65                  70                  75                  80  


Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys 
                85                  90                  95      


Leu Lys Gln Pro Gly Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn 
            100                 105                 110         


Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn 
        115                 120                 125             


Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
    130                 135                 140                 


Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
145                 150                 155                 160 


Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
                165                 170                 175     


Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
            180                 185                 190         


Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
        195                 200                 205             


Ala Asn Pro Asn Ala Asn Pro Asn Lys Asn Asn Gln Gly Asn Gly Gln 
    210                 215                 220                 


Gly His Asn Met Pro Asn Asp Pro Asn Arg Asn Val Asp Glu Asn Ala 
225                 230                 235                 240 


Asn Ala Asn Asn Ala Val Lys Asn Asn Asn Asn Glu Glu Pro Ser Asp 
                245                 250                 255     


Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu Ser Thr 
            260                 265                 270         


Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg 
        275                 280                 285             


Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Glu 
    290                 295                 300                 


Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu His His His His His 
305                 310                 315                 320 


His 
    


<210>  7
<211>  179
<212>  PRT
<213>  Plasmodium falciparum

<400>  7

Glu Ala Glu Ala Tyr Val Lys Val Thr Val Asp Thr Val Cys Lys Arg 
1               5                   10                  15      


Gly Phe Leu Ile Gln Met Ser Gly His Leu Glu Cys Lys Cys Glu Asn 
            20                  25                  30          


Asp Leu Val Leu Val Asn Glu Glu Thr Cys Glu Glu Lys Val Leu Lys 
        35                  40                  45              


Cys Asp Glu Lys Thr Val Asn Lys Pro Cys Gly Asp Phe Ser Lys Cys 
    50                  55                  60                  


Ile Lys Ile Asp Gly Asn Pro Val Ser Tyr Ala Cys Lys Cys Asn Leu 
65                  70                  75                  80  


Gly Tyr Asp Met Val Asn Asn Val Cys Ile Pro Asn Glu Cys Lys Gln 
                85                  90                  95      


Val Thr Cys Gly Asn Gly Lys Cys Ile Leu Asp Thr Ser Asn Pro Val 
            100                 105                 110         


Lys Thr Gly Val Cys Ser Cys Asn Ile Gly Lys Val Pro Asn Val Gln 
        115                 120                 125             


Asp Gln Asn Lys Cys Ser Arg Asp Gly Glu Thr Lys Cys Ser Leu Lys 
    130                 135                 140                 


Cys Leu Lys Glu Gln Glu Thr Cys Lys Ala Val Asp Gly Ile Tyr Lys 
145                 150                 155                 160 


Cys Asp Cys Lys Asp Gly Phe Ile Ile Asp Gln Glu Ser Ser Ile Cys 
                165                 170                 175     


Thr Asp Pro 
            


<210>  8
<211>  180
<212>  PRT
<213>  Plasmodium vivax

<400>  8

Glu Ala Glu Ala Ser Ala Val Thr Val Asp Thr Ile Cys Lys Asn Gly 
1               5                   10                  15      


Gln Leu Val Gln Met Ser Asn His Phe Lys Cys Met Cys Asn Glu Gly 
            20                  25                  30          


Leu Val His Leu Ser Glu Asn Thr Cys Glu Glu Lys Asn Glu Cys Lys 
        35                  40                  45              


Lys Glu Thr Leu Gly Lys Ala Cys Gly Glu Phe Gly Gln Cys Ile Glu 
    50                  55                  60                  


Asn Pro Asp Pro Ala Gln Val Asn Met Tyr Lys Cys Gly Cys Ile Glu 
65                  70                  75                  80  


Gly Tyr Thr Leu Lys Glu Asp Thr Cys Val Leu Asp Val Cys Gln Tyr 
                85                  90                  95      


Lys Asn Cys Gly Glu Ser Gly Glu Cys Ile Val Glu Tyr Leu Ser Glu 
            100                 105                 110         


Ile Gln Ser Ala Gly Cys Ser Cys Ala Ile Gly Lys Val Pro Asn Pro 
        115                 120                 125             


Glu Asp Glu Lys Lys Cys Thr Lys Thr Gly Glu Thr Ala Cys Gln Leu 
    130                 135                 140                 


Lys Cys Asn Thr Asp Asn Glu Val Cys Lys Asn Val Glu Gly Val Tyr 
145                 150                 155                 160 


Lys Cys Gln Cys Met Glu Gly Phe Thr Phe Asp Lys Glu Lys Asn Val 
                165                 170                 175     


Cys Leu Gly Pro 
            180 


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Asp or Ala

<400>  9

Xaa Gly Gln Pro Ala Gly Asp Arg Ala 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly or Asp

<400>  10

Xaa Asn Gly Pro Gly Ala Asn Gly Ala 
1               5                   


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Asn Ala Ala Gly 
1               


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Gln Ala Gln Gly Asp Gly Ala Asn Gly Gln Pro 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala Ala 
1               5                   10      


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro 
1               5                   10                  15      


Cys Ser Val Thr 
            20  


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val 
1               5                   10                  15      


Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val 
            20                  25                  30          


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


Asn Ala Asn Pro 
            20  


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
1               5                   10                  15      


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
1               5                   10                  15      


Asn Pro Asn Ala 
            20  


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
1               5                   10                  15      


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
1               5                   10                  15      


Pro Asn Ala Asn 
            20  


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
1               5                   10                  15      


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
1               5                   10                  15      


Ala Asn Pro Asn 
            20  


<210>  24
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


Asn Ala Asn Pro Asn Ala Asn Pro 
            20                  


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro 
            20                  25                  30          


Cys Ser Val Thr 
        35      


<210>  26
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10                  15      


Asn Ala Asn Pro Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr 
            20                  25                  30          


Glu Trp Ser Pro Cys Ser Val Thr 
        35                  40  


<210>  27
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
1               5                   10                  15      


Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro 
            20                  25                  30          


Cys Ser Val Thr 
        35      


<210>  28
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
1               5                   10                  15      


Ala Asn Pro Asn Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr 
            20                  25                  30          


Glu Trp Ser Pro Cys Ser Val Thr 
        35                  40  


<210>  29
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
1               5                   10                  15      


Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro 
            20                  25                  30          


Cys Ser Val Thr 
        35      


<210>  30
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
1               5                   10                  15      


Asn Pro Asn Ala Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr 
            20                  25                  30          


Glu Trp Ser Pro Cys Ser Val Thr 
        35                  40  


<210>  31
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
1               5                   10                  15      


Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro 
            20                  25                  30          


Cys Ser Val Thr 
        35      


<210>  32
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
1               5                   10                  15      


Pro Asn Ala Asn Glu Tyr Leu Asn Lys Ile Gln Asn Ser Leu Ser Thr 
            20                  25                  30          


Glu Trp Ser Pro Cys Ser Val Thr 
        35                  40  


