                         SEQUENCE LISTING

<110>  Pincus, Matthew R
       Michl, Josef
 
<120>  MEMBRANE RESIDENT PEPTIDE IN ANTI-CANCER PEPTIDES CAUSES TUMOR 
       CELL NECROSIS RATHER THAN APOPTOSIS OF CANCER CELLS

<130>  178-388 PCT

<150>  61/102,590
<151>  2008-10-03

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Membrane resident peptide (MRP), reverseomer of Antennapedia

<400>  1

Lys Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg 
1               5                   10                  15      


Gly 
    


<210>  2
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PNC-27

<400>  2

Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Lys 
1               5                   10                  15      


Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25                  30          


<210>  3
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PNC-28

<400>  3

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Lys Lys Trp Lys Met Arg 
1               5                   10                  15      


Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25          


<210>  4
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PNC-29

<400>  4

Met Pro Phe Ser Thr Gly Lys Arg Ile Met Leu Gly Glu Lys Lys Trp 
1               5                   10                  15      


Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25                  30  


<210>  5
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide from cytochrome P450 (aka "X13")

<400>  5

Met Pro Phe Ser Thr Gly Lys Arg Ile Met Leu Gly Glu 
1               5                   10              


<210>  6
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PNC-7

<400>  6

Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Lys Lys Trp 
1               5                   10                  15      


Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25                  30  


<210>  7
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ras-p21 residues 35-47

<400>  7

Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp 
1               5                   10              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PNC-26, residues 12-26 of the HDM-2 binding domain of p53

<400>  8

Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu 
1               5                   10                  15  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HIV-1 TAT(47-60), membrane resident peptide

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10                  


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D-TAT, membrane resident peptide

<400>  10

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R-TAT G(R)9PPQ, membrane resident peptide

<400>  11

Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro Gln 
1               5                   10              


<210>  12
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SV40-NLS, membrane resident peptide

<400>  12

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  13
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nucleoplasmin-NLS, membrane resident peptide

<400>  13

Lys Arg Pro Ala Ala Ile Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIV REV (34-50), membrane resident peptide

<400>  14

Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
1               5                   10                  15      


Arg 
    


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FHV (35-49) coat, membrane resident peptide

<400>  15

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  16
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BMV GAG (7-25), membrane resident peptide

<400>  16

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  17
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HTLV-II REX 4-16, membrane resident peptide

<400>  17

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  18
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CCMV GAG (7-25), membrane resident peptide

<400>  18

Lys Leu Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Lys Asn Lys Arg 
1               5                   10                  15      


Asn Thr Arg 
            


<210>  19
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P22 N (14-30), membrane resident peptide

<400>  19

Asn Ala Lys Thr Arg Arg His Glu Arg Arg Arg Lys Leu Ala Ile Glu 
1               5                   10                  15      


Arg 
    


<210>  20
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LAMBDA N(1-22), membrane resident peptide

<400>  20

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn 
            20          


<210>  21
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Phi N (12-29), membrane resident peptide

<400>  21

Thr Ala Lys Thr Arg Tyr Lys Ala Arg Arg Ala Glu Leu Ile Ala Glu 
1               5                   10                  15      


Arg Arg 
        


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YEAST PRP6 (129-124), membrane resident peptide

<400>  22

Thr Arg Arg Asn Lys Arg Asn Arg Ile Gln Glu Gln Leu Asn Arg Lys 
1               5                   10                  15      


<210>  23
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HUMAN U2AF, membrane resident peptide

<400>  23

Ser Gln Met Thr Arg Gln Ala Arg Arg Leu Tyr Val 
1               5                   10          


<210>  24
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HUMAN C-FOS (139-164), membrane resident peptide

<400>  24

Lys Arg Arg Ile Arg Arg Glu Arg Asn Lys Met Ala Ala Ala Lys Ser 
1               5                   10                  15      


Arg Asn Arg Arg Arg Glu Leu Thr Asp Thr 
            20                  25      


<210>  25
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HUMAN C-JUN (252-279), membrane resident peptide

<400>  25

Arg Ile Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser 
1               5                   10                  15      


Lys Ser Arg Lys Arg Lys Leu Glu Arg Ile Ala Arg 
            20                  25              


<210>  26
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YEAST GCN4, membrane resident peptide

<400>  26

Lys Arg Ala Arg Asn Thr Glu Ala Ala Arg Arg Ser Arg Ala Arg Lys 
1               5                   10                  15      


Leu Gln Arg Met Lys Gln 
            20          


<210>  27
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Example membrane resident peptide (MRP)

<400>  27

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  28
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  p-vec, membrane resident peptide

<400>  28

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala Lys Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  29
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  (Arg)8 or any poly-R from (R)4-(R)16, membrane resident peptide

<400>  29

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  30
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Kozak sequence

<400>  30
gccaccatgg                                                              10


<210>  31
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sense strand sequence of cDNA encoding the p53 17-26 sequence

<400>  31
agtcgaattc gccaccatgg aaacattttc agacctatgg aaactacttt gagcggccgc       60

agtc                                                                    64


<210>  32
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  residues 17-26 of HDM-2 binding domain of p53

<400>  32

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu 
1               5                   10  


