                         SEQUENCE LISTING

<110>  WALKER, Kenneth W.
       GEGG, Jr. , Colin V.
       HECHT, Randy I.
       BELOUSKI, Edward J.
       LI, Yue-Sheng
       MICHAELS, Mark L.
       XU, Jing
       ELLISON, Murielle M.
 
<120>  FGF21 MUTANTS AND USES THEREOF

<130>  A-1451-US-PSP

<140>  61/195761
<141>  2008-10-10

<160>  34    

<170>  PatentIn version 3.3

<210>  1
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  1
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt     60

cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc    120

gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac    180

ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc    240

ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg    300

ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc    360

tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac    420

ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga    480

ccagctcgct tcctgccact accaggcctg ccccccgcac ccccggagcc acccggaatc    540

ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc    600

cagggccgaa gccccagcta cgcttcctga                                     630


<210>  2
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  3
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  3
caccccatcc ctgactccag tcctctcctg caattcgggg gccaagtccg gcagcggtac     60

ctctacacag atgatgccca gcagacagaa gcccacctgg agatcaggga ggatgggacg    120

gtggggggcg ctgctgacca gagccccgaa agtctcctgc agctgaaagc cttgaagccg    180

ggagttattc aaatcttggg agtcaagaca tccaggttcc tgtgccagcg gccagatggg    240

gccctgtatg gatcgctcca ctttgaccct gaggcctgca gcttccggga gctgcttctt    300

gaggacggat acaatgttta ccagtccgaa gcccacggcc tcccgctgca cctgccaggg    360

aacaagtccc cacaccggga ccctgcaccc cgaggaccag ctcgcttcct gccactacca    420

ggcctgcccc ccgcaccccc ggagccaccc ggaatcctgg ccccccagcc ccccgatgtg    480

ggctcctcgg accctctgag catggtggga ccttcccagg gccgaagccc cagctacgct    540

tcctga                                                               546


<210>  4
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  4

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  5
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<400>  5

Xaa Xaa Asn Xaa Xaa Gly 
1               5       


<210>  6
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  6

Gly Gly Gly Gly 
1               


<210>  7
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  7

Gly Gly Gly Gly Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  8

Gly Gly Gly Gly Ser 
1               5   


<210>  9
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  10
<211>  25
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  11
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  11

Gly Gly Glu Gly Gly Gly 
1               5       


<210>  12
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  12

Gly Gly Glu Glu Glu Gly Gly Gly 
1               5               


<210>  13
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  13

Gly Glu Glu Glu Gly 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  14

Gly Glu Glu Glu 
1               


<210>  15
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  15

Gly Gly Asp Gly Gly Gly 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  16

Gly Gly Asp Asp Asp Gly Gly 
1               5           


<210>  17
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  17

Gly Asp Asp Asp Gly 
1               5   


<210>  18
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  18

Gly Asp Asp Asp 
1               


<210>  19
<211>  21
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  19

Gly Gly Gly Gly Ser Asp Asp Ser Asp Glu Gly Ser Asp Gly Glu Asp 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  20
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  20

Trp Glu Trp Glu Trp 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  21

Phe Glu Phe Glu Phe 
1               5   


<210>  22
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  22

Glu Glu Glu Trp Trp Trp 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  23

Glu Glu Glu Phe Phe Phe 
1               5       


<210>  24
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  24

Trp Trp Glu Glu Glu Trp Trp 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence

<400>  25

Phe Phe Glu Glu Glu Phe Phe 
1               5           


<210>  26
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<400>  26

Xaa Xaa Tyr Xaa Xaa Gly 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<400>  27

Xaa Xaa Ser Xaa Xaa Gly 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X IS INDEPENDENTLY ANY AMINO ACID RESIDUE

<400>  28

Xaa Xaa Thr Xaa Xaa Gly 
1               5       


<210>  29
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer Sequence

<400>  29
atggtggaac cttcccaggg ccgaagc                                         27


<210>  30
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer Sequence

<400>  30
ctcctcggac cctctgagca tggtgggacc ttcccagggc cgaagcccca                50


<210>  31
<211>  50
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer Sequence

<400>  31
gaggagcctg ggagactcgt accaccctgg aagggtcccg gcttcggggt                50


<210>  32
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer Sequence

<400>  32
ggaaggttcc accatgctca gagggtccga                                      30


<210>  33
<211>  40
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer Sequence

<400>  33
aggaggaata acatatgcat ccaattccag attcttctcc                           40


<210>  34
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Primer Sequence

<400>  34
tagtgagctc gaattcttag gaagcgtagc tgg                                  33


