                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Los Alamos National Security LLC
 
<120>  USE OF HIV MOSAIC ENVELOPE PROTEINS TO OPTIMIZE T-CELL RESPONSES 
       AGAINST HIV ENVELOPE

<130>  705228

<150>  61/195,845
<151>  2008-10-10

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  860
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Met Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Val Pro Ile Glu Glu Asn Ser Asn Ser Ser Asn Ser Asn 
            180                 185                 190         


Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Ile Lys 
            340                 345                 350         


Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser 
        355                 360                 365             


Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asn Ile 
385                 390                 395                 400 


Asn Gly Thr Trp Asn Gly Thr Asn Gly Thr Thr Glu Ser Asn Asp Thr 
                405                 410                 415     


Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu 
            420                 425                 430         


Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys 
        435                 440                 445             


Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn 
    450                 455                 460                 


Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
                485                 490                 495     


Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu 
            500                 505                 510         


Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Ser Glu 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn 
625                 630                 635                 640 


Tyr Thr Asp Ile Ile Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu 
            660                 665                 670         


Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe 
        675                 680                 685             


Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val 
    690                 695                 700                 


Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe 
705                 710                 715                 720 


Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile 
                725                 730                 735     


Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val 
            740                 745                 750         


Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu 
        755                 760                 765             


Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile 
    770                 775                 780                 


Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp 
785                 790                 795                 800 


Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser 
                805                 810                 815     


Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile 
            820                 825                 830         


Ile Glu Val Val Gln Arg Ala Cys Arg Ala Ile Leu His Ile Pro Arg 
        835                 840                 845             


Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu Pro 
    850                 855                 860 


<210>  2
<211>  847
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser 
            260                 265                 270         


Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn 
                325                 330                 335     


Asn Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr 
    370                 375                 380                 


Gln Leu Phe Asn Ser Thr Trp Asn Val Asn Gly Thr Trp Asn Gly Thr 
385                 390                 395                 400 


Gly Ser Glu Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asn Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
                485                 490                 495     


Val Gln Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly 
            500                 505                 510         


Phe Leu Gly Thr Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu 
        515                 520                 525             


Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn 
    530                 535                 540                 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr 
545                 550                 555                 560 


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg 
                565                 570                 575     


Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys 
            580                 585                 590         


Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys 
        595                 600                 605             


Ser Gln Glu Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg 
    610                 615                 620                 


Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile Glu Glu Ser 
625                 630                 635                 640 


Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 
                645                 650                 655     


Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr 
            660                 665                 670         


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
        675                 680                 685             


Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 


Pro Leu Ser Leu Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro Asp Arg 
705                 710                 715                 720 


Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser 
                725                 730                 735     


Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ile Trp Asp Asp Leu Arg 
            740                 745                 750         


Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile 
        755                 760                 765             


Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu 
    770                 775                 780                 


Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn 
785                 790                 795                 800 


Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly 
                805                 810                 815     


Thr Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp Arg Ala Ile Leu 
            820                 825                 830         


His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840                 845         


<210>  3
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Gly Ser Ser Lys Thr Asn Val 
    130                 135                 140                 


Ser Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Asn Ser Asn Ser Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Phe Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Ala Lys Lys Leu Lys 
            340                 345                 350         


Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ser Leu Asn Ser 
385                 390                 395                 400 


Ser Ala Pro Asp Asp Thr Glu Ser Asn Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Asn Lys Glu Thr Asn Glu 
    450                 455                 460                 


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Arg Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asn Glu Ile Trp Asp 
    610                 615                 620                 


Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn 
625                 630                 635                 640 


Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp 
            660                 665                 670         


Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu 
705                 710                 715                 720 


Thr Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe 
            740                 745                 750         


Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu 
    770                 775                 780                 


Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu 
785                 790                 795                 800 


Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys 
                805                 810                 815     


Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly 
            820                 825                 830         


Thr Asp Arg Ile Ile Glu Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg 
        835                 840                 845             


Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855                 860             


<210>  4
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr Tyr Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Ala Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Asn Thr Arg Asn Ser Thr Asn Thr Val Asn 
    130                 135                 140                 


Asn Thr Met Asn Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr 
145                 150                 155                 160 


Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile Ser 
            180                 185                 190         


Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
            260                 265                 270         


Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser 
        275                 280                 285             


Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Val 
    290                 295                 300                 


Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
305                 310                 315                 320 


Asn Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Gln Trp Asn Asn 
                325                 330                 335     


Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asn Asp Thr Arg Leu Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Asn Ser Thr Glu Gly Ser Asp Asn Thr Gly Gly Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Ser 
    450                 455                 460                 


Ser Asn Asn Asn Asn Asp Thr Glu Ile Phe Arg Pro Gly Gly Gly Asn 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Asn Glu Leu Tyr Lys Tyr Lys Val Val Gln 
                485                 490                 495     


Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val 
            500                 505                 510         


Gln Arg Glu Lys Arg Ala Val Gly Thr Ile Gly Ala Met Phe Leu Gly 
        515                 520                 525             


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu 
    530                 535                 540                 


Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn 
545                 550                 555                 560 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 
                565                 570                 575     


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg 
            580                 585                 590         


Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Tyr Ser Gly Lys 
        595                 600                 605             


Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys 
    610                 615                 620                 


Ser Leu Glu Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg 
625                 630                 635                 640 


Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile Glu Glu Ser 
                645                 650                 655     


Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 
            660                 665                 670         


Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr 
        675                 680                 685             


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile 
    690                 695                 700                 


Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Lys Gly Tyr Ser 
705                 710                 715                 720 


Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro Asp Arg 
                725                 730                 735     


Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser 
            740                 745                 750         


Val Arg Leu Val Ser Gly Phe Leu Ala Leu Ile Trp Asp Asp Leu Arg 
        755                 760                 765             


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile 
    770                 775                 780                 


Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu 
785                 790                 795                 800 


Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn 
                805                 810                 815     


Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly 
            820                 825                 830         


Thr Asp Arg Val Ile Glu Val Val Gln Arg Ala Cys Arg Ala Ile Leu 
        835                 840                 845             


His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860             


<210>  5
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg 
                165                 170                 175     


Leu Asp Ile Val Pro Leu Asn Glu Ser Asn Ser Asn Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile 
            260                 265                 270         


Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His 
        275                 280                 285             


Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys Lys Leu Ala Glu His 
            340                 345                 350         


Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Asn Ser Thr Trp Asn Asn Thr Ser Thr Trp 
385                 390                 395                 400 


Asn Asp Asn Gly Asn Asp Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Val Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Ile Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg 
                485                 490                 495     


Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Lys 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                565                 570                 575     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Leu Asn Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp 
    610                 615                 620                 


Asp Lys Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
                645                 650                 655     


Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly Leu Ile Gly Leu 
        675                 680                 685             


Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Pro 
705                 710                 715                 720 


Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp 
                725                 730                 735     


Arg Ser Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp 
            740                 745                 750         


Leu Arg Ser Leu Cys Leu Phe Cys Tyr His Arg Leu Arg Asp Leu Ile 
        755                 760                 765             


Leu Ile Ala Ala Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Arg 
    770                 775                 780                 


Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val 
785                 790                 795                 800 


Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp 
                805                 810                 815     


Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu 
            820                 825                 830         


Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855     


<210>  6
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Val Asn Asn Ile Thr Asn Val 
    130                 135                 140                 


Pro Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Asp Asn Gly Lys Asn Asp Ser 
            180                 185                 190         


Thr Asn Thr Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Thr Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Ser Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala 
305                 310                 315                 320 


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys 
                325                 330                 335     


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Thr Glu 
            340                 345                 350         


Lys Leu Lys Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Gly Thr Asp Arg Val Gln Glu Ser Asn Ser Thr Glu Ser Asn Asp Thr 
                405                 410                 415     


Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg 
            420                 425                 430         


Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Ser Gly Arg Ile Asn Cys 
        435                 440                 445             


Val Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Asn Thr 
    450                 455                 460                 


Asn Glu Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu 
                485                 490                 495     


Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Thr Ala 
        515                 520                 525             


Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Ser Glu Ile 
    610                 615                 620                 


Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr 
625                 630                 635                 640 


Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu 
                645                 650                 655     


Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp 
            660                 665                 670         


Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile 
        675                 680                 685             


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu 
    690                 695                 700                 


Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln 
705                 710                 715                 720 


Thr Pro Thr His His Gln Arg Glu Pro Asp Arg Pro Glu Arg Ile Glu 
                725                 730                 735     


Glu Gly Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser 
            740                 745                 750         


Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe 
        755                 760                 765             


Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val 
    770                 775                 780                 


Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu 
785                 790                 795                 800 


Gly Leu Lys Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly Gln Glu Leu 
                805                 810                 815     


Lys Asn Ser Ala Ile Ser Leu Leu Asn Thr Thr Ala Ile Ala Val Ala 
            820                 825                 830         


Gly Trp Thr Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp Arg Ala 
        835                 840                 845             


Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu 
    850                 855                 860                 


Leu 
865 


<210>  7
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Ser Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Ile Asn Asn Ile Thr Asn Val 
    130                 135                 140                 


Pro Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Asn Asn Lys Ser Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Lys Gln Ala Cys 
        195                 200                 205             


Pro Lys Ile Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Lys Asn Val Ser Ser Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn 
    290                 295                 300                 


Asn Thr Arg Thr Ser Ile Thr Ile Gly Pro Gly Gln Val Phe Tyr Arg 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Gly Val Leu Lys Gln Val Thr Glu Lys Leu Lys 
            340                 345                 350         


Glu His Phe Lys Asn Lys Thr Ile Ile Phe Gln Pro Pro Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Met His His Phe Asn Cys Arg Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Thr Gln Leu Phe Asn Asn Thr Cys Ile Gly Asn Glu 
385                 390                 395                 400 


Thr Ile Glu Gly Cys Lys Asn Ile Thr Leu Pro Cys Lys Ile Lys Gln 
                405                 410                 415     


Thr Ile Asn Met Trp Gln Gly Ala Gly Gln Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Ser Gly Arg Ile Asn Cys Val Ser Asn Ile Thr Gly Ile Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Val Asn Asn Thr Asn Asn Glu Thr Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asn Ile Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Met 
            500                 505                 510         


Ile Phe Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Ser Ala Ala Ser 
        515                 520                 525             


Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
    530                 535                 540                 


Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
545                 550                 555                 560 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
                565                 570                 575     


Val Glu Arg Tyr Leu Lys Asp Gln Lys Phe Leu Gly Leu Trp Gly Cys 
            580                 585                 590         


Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Thr Trp 
        595                 600                 605             


Ser Asn Arg Ser Phe Glu Glu Ile Trp Asn Asn Met Thr Trp Ile Glu 
    610                 615                 620                 


Trp Glu Arg Glu Ile Ser Asn Tyr Thr Asn Gln Ile Tyr Glu Ile Leu 
625                 630                 635                 640 


Thr Glu Ser Gln Asn Gln Gln Asp Arg Asn Glu Lys Asp Leu Leu Glu 
                645                 650                 655     


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp 
            660                 665                 670         


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
        675                 680                 685             


Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln 
    690                 695                 700                 


Gly Tyr Ser Pro Leu Ser Leu Gln Thr Pro Thr His His Gln Arg Glu 
705                 710                 715                 720 


Pro Asp Arg Pro Glu Arg Ile Glu Glu Gly Gly Gly Glu Gln Gly Arg 
                725                 730                 735     


Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp 
            740                 745                 750         


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe 
        755                 760                 765             


Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly Arg Ser Ser Leu 
    770                 775                 780                 


Lys Gly Leu Arg Arg Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu 
785                 790                 795                 800 


Leu Leu Tyr Trp Gly Gln Glu Leu Lys Ile Ser Ala Ile Ser Leu Phe 
                805                 810                 815     


Asn Ala Thr Ala Ile Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu 
            820                 825                 830         


Val Ala Gln Gly Thr Trp Arg Ala Ile Leu His Ile Pro Arg Arg Ile 
        835                 840                 845             


Arg Gln Gly Leu Glu Arg Ala Leu Gln 
    850                 855         


<210>  8
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Arg Ala Lys Glu Thr Arg Arg Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Leu Asn Asn Val Thr Tyr Val Asn Ile Thr Glu 
    130                 135                 140                 


Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Val Gln 
145                 150                 155                 160 


Asp Lys Met Lys Lys Ala Tyr Ala Phe Phe Tyr Arg Leu Asp Val Val 
                165                 170                 175     


Pro Ile Asp Asp Asn His Gly Asn Ser Ser Ser Asn Ser Ser Ser Asn 
            180                 185                 190         


Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro 
225                 230                 235                 240 


Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val 
            260                 265                 270         


Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Ile Ile Ile Val 
        275                 280                 285             


Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg Pro Asn Asn Asn 
    290                 295                 300                 


Thr Arg Arg Gly Val Thr Ile Gly Pro Gly Arg Val Phe Tyr Thr Gly 
305                 310                 315                 320 


Glu Val Thr Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Thr 
                325                 330                 335     


Arg Trp Lys Asn Thr Leu Lys Gln Val Glu Ile Lys Leu Lys Glu Gln 
            340                 345                 350         


Phe Gly Asn Lys Thr Ile Asn Phe Ser Gln Pro Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Val Leu His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Asn Thr Thr Leu Leu Asn Asp Thr Ala Glu 
385                 390                 395                 400 


Ser Asn Asp Asn Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asn Asp Asn Asn Thr Asp Asn Thr Thr Glu Ile Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Gln Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Thr Ile Gly Ala 
            500                 505                 510         


Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu 
                565                 570                 575     


Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr Ser 
        595                 600                 605             


Trp Ser Asn Lys Ser Leu Asn Asp Ile Trp Asp Asn Met Thr Trp Met 
    610                 615                 620                 


Gln Trp Asp Arg Glu Ile Asn Asn Phe Thr Glu Tyr Ile Tyr Thr Leu 
625                 630                 635                 640 


Leu Glu Asn Ala Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 
                645                 650                 655     


Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn 
            660                 665                 670         


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
        675                 680                 685             


Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg 
    690                 695                 700                 


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro Ala Arg Arg 
705                 710                 715                 720 


Glu Pro Asp Arg Pro Glu Gly Thr Glu Gly Glu Gly Gly Glu Arg Asp 
                725                 730                 735     


Lys Asp Arg Ser Val Arg Leu Val His Gly Phe Leu Ala Leu Ile Trp 
            740                 745                 750         


Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp 
        755                 760                 765             


Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly 
    770                 775                 780                 


Trp Glu Ile Leu Lys Tyr Trp Gly Asn Leu Leu Gln Tyr Trp Ser Gln 
785                 790                 795                 800 


Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asp Ala Ile Ala Ile Ala 
                805                 810                 815     


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Val Gln Arg Ile Phe 
            820                 825                 830         


Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg 
        835                 840                 845             


Ala Leu Leu 
    850     


<210>  9
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Arg Val Arg Gly Thr Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Val Leu Gly Phe Trp Met Leu Met Ile Cys Asn Gly Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Leu Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Ser Arg Asn Val Ser Ser Tyr Asn Thr Tyr Asn 
    130                 135                 140                 


Gly Ser Val Glu Glu Ile Lys Asn Cys Ser Phe Asn Ala Thr Pro Glu 
145                 150                 155                 160 


Val Arg Asp Arg Lys Gln Arg Met Tyr Ala Leu Phe Tyr Gly Leu Asp 
                165                 170                 175     


Ile Val Pro Leu Asn Lys Lys Asn Ser Ser Glu Asn Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile 
            260                 265                 270         


Ile Arg Ser Glu Asn Leu Thr Asn Asn Val Lys Thr Ile Ile Val His 
        275                 280                 285             


Leu Asn Gln Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Asp 
                325                 330                 335     


Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys Lys Leu Ala Glu His 
            340                 345                 350         


Phe His Asn Lys Thr Ile Lys Phe Ala Ser Ser Ser Gly Gly Asp Leu 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Ser Gly Leu Phe Asn Gly Thr Tyr Met Pro Thr Tyr Met Pro 
385                 390                 395                 400 


Asn Gly Thr Glu Ser Asn Ser Asn Ser Thr Ile Thr Ile Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Thr Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Leu Leu Val His Asp Gly Gly Ile Lys Glu Asn Asp Thr Glu Asn 
    450                 455                 460                 


Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Ala Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
        515                 520                 525             


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln Ala Arg Gln 
    530                 535                 540                 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
545                 550                 555                 560 


Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
                565                 570                 575     


Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln 
            580                 585                 590         


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
        595                 600                 605             


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Thr Gln Ser Glu Ile Trp 
    610                 615                 620                 


Asn Asn Met Thr Trp Met Gln Trp Asp Arg Glu Val Ser Asn Tyr Thr 
625                 630                 635                 640 


Asn Ile Ile Tyr Ser Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys 
                645                 650                 655     


Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Ser 
            660                 665                 670         


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
        675                 680                 685             


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser 
    690                 695                 700                 


Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
705                 710                 715                 720 


Leu Thr Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu 
                725                 730                 735     


Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser Ile Arg Leu Val Asn Gly 
            740                 745                 750         


Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser 
        755                 760                 765             


Tyr His Arg Leu Arg Asp Phe Ile Ser Val Ala Ala Arg Val Val Glu 
    770                 775                 780                 


Leu Leu Gly Arg Ser Ser Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu 
785                 790                 795                 800 


Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Phe 
                805                 810                 815     


Asp Ser Ile Ala Ile Val Val Ala Glu Gly Thr Asp Arg Ile Ile Glu 
            820                 825                 830         


Leu Val Gln Gly Phe Cys Arg Ala Ile Arg Asn Ile Pro Thr Arg Ile 
        835                 840                 845             


Arg Gln Gly Phe Glu Ala Ala Leu Gln 
    850                 855         


<210>  10
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser 
    130                 135                 140                 


Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Val Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Ile 
305                 310                 315                 320 


Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser 
                325                 330                 335     


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp Gln Glu Val 
    370                 375                 380                 


Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
        435                 440                 445             


Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Leu Gly 
    450                 455                 460                 


Ala Val Phe Leu Gly Phe Leu Gly Thr Ala Gly Ser Thr Met Gly Ala 
465                 470                 475                 480 


Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile 
                485                 490                 495     


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
            500                 505                 510         


Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
        515                 520                 525             


Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp 
    530                 535                 540                 


Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser 
545                 550                 555                 560 


Ser Trp Ser Asn Lys Ser Gln Glu Glu Ile Trp Asn Asn Met Thr Trp 
                565                 570                 575     


Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr 
            580                 585                 590         


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
        595                 600                 605             


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr 
    610                 615                 620                 


Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu 
625                 630                 635                 640 


Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val 
                645                 650                 655     


Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Leu Pro Ala Pro 
            660                 665                 670         


Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln 
        675                 680                 685             


Gly Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ile 
    690                 695                 700                 


Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
705                 710                 715                 720 


Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg 
                725                 730                 735     


Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser 
            740                 745                 750         


Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile 
        755                 760                 765             


Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Ala Gln Arg Ala 
    770                 775                 780                 


Trp Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu 
785                 790                 795                 800 


Arg Ala Leu Leu 
                


<210>  11
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Glu Val Arg Asn Cys Ser Phe Asn Met Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Ile Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Phe Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Ser Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys 
    290                 295                 300                 


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Ala Lys 
305                 310                 315                 320 


Lys Leu Lys Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser 
                325                 330                 335     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val 
    370                 375                 380                 


Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Glu Thr Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Arg 
        435                 440                 445             


Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly 
    450                 455                 460                 


Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
465                 470                 475                 480 


Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
                485                 490                 495     


Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
            500                 505                 510         


Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val 
        515                 520                 525             


Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
    530                 535                 540                 


Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala 
545                 550                 555                 560 


Ser Trp Ser Asn Lys Ser Leu Asn Glu Ile Trp Asp Asn Met Thr Trp 
                565                 570                 575     


Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr Arg 
            580                 585                 590         


Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu 
        595                 600                 605             


Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile Ser 
    610                 615                 620                 


Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu 
625                 630                 635                 640 


Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val 
                645                 650                 655     


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro 
            660                 665                 670         


Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln 
        675                 680                 685             


Asp Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala 
    690                 695                 700                 


Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
705                 710                 715                 720 


Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly His Ser 
                725                 730                 735     


Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Gly 
            740                 745                 750         


Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser 
        755                 760                 765             


Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile 
    770                 775                 780                 


Ile Glu Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg 
785                 790                 795                 800 


Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
                805                 810     


<210>  12
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr Tyr Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Ala Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser 
    130                 135                 140                 


Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Val Val Pro Ile Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Leu Ser Arg Ala Gln Trp Asn Asn Thr Leu Lys Gln Ile Val Ile 
305                 310                 315                 320 


Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser 
                325                 330                 335     


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val 
    370                 375                 380                 


Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Ile Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Asn Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
        435                 440                 445             


Ala Lys Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln 
    450                 455                 460                 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
465                 470                 475                 480 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala 
                485                 490                 495     


Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Glu Ile Trp Asn Asn 
            500                 505                 510         


Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu 
        515                 520                 525             


Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Val Gly Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val 
            580                 585                 590         


Asn Arg Val Arg Lys Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu 
        595                 600                 605             


Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly 
    610                 615                 620                 


Gly Glu Gln Gly Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu 
            660                 665                 670         


Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln 
        675                 680                 685             


Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala 
    690                 695                 700                 


Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Val 
705                 710                 715                 720 


Gln Arg Ala Cys Arg Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln 
                725                 730                 735     


Gly Leu Glu Arg Ala Leu Leu 
            740             


<210>  13
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Ile Val Pro Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Ile Ser Arg Ala Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys 
305                 310                 315                 320 


Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro Ser 
                325                 330                 335     


Ser Gly Gly Asp Pro Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Ile Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp Gln Glu Val 
    370                 375                 380                 


Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Glu Thr Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg 
        435                 440                 445             


Ala Lys Leu Thr Val Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln 
    450                 455                 460                 


Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu 
465                 470                 475                 480 


Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
                485                 490                 495     


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asn Thr 
        515                 520                 525             


Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe 
545                 550                 555                 560 


Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile 
            580                 585                 590         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr 
        595                 600                 605             


Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly 
    610                 615                 620                 


Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Leu Ile Leu Ile Ala Ala Arg Ala Val Glu Leu Leu 
            660                 665                 670         


Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys 
        675                 680                 685             


Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser 
    690                 695                 700                 


Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr 
705                 710                 715                 720 


Asp Arg Ile Ile Glu Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn 
                725                 730                 735     


Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
            740                 745                 750 


<210>  14
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Glu Val Arg Asn Cys Ser Phe Asn Met Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Ile Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Thr Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Ser Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys 
    290                 295                 300                 


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Thr Glu 
305                 310                 315                 320 


Lys Leu Lys Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser 
                325                 330                 335     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val 
    370                 375                 380                 


Gly Gln Ala Met Tyr Ala Pro Pro Ile Ser Gly Arg Ile Asn Cys Val 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Lys 
        435                 440                 445             


Ala Lys Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
    450                 455                 460                 


Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu 
465                 470                 475                 480 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala 
                485                 490                 495     


Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
        515                 520                 525             


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val 
            580                 585                 590         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Pro Thr 
        595                 600                 605             


His His Gln Arg Glu Pro Asp Arg Pro Glu Arg Ile Glu Glu Gly Gly 
    610                 615                 620                 


Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ala Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu 
            660                 665                 670         


Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys 
        675                 680                 685             


Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly Gln Glu Leu Lys Asn Ser 
    690                 695                 700                 


Ala Ile Ser Leu Leu Asn Thr Thr Ala Ile Ala Val Ala Gly Trp Thr 
705                 710                 715                 720 


Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp Arg Ala Ile Leu His 
                725                 730                 735     


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu Leu 
            740                 745                 750 


<210>  15
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Pro Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Ile Ile Leu Gly Leu Ile Met Ile Cys Ser Asn Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Lys Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Gly Glu Met Lys Asn Cys Ser Tyr Asn Met Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Lys Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Val Val Gln Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Arg Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Val Arg Ile Arg Ser Glu Asn Ile Ser Asp Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val Gln Leu Thr Glu Pro Val Thr Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly Pro Gly Gln Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Val Ser Ser Ser Lys Trp Asn Lys Thr Leu Gln Gln Val Val Thr 
305                 310                 315                 320 


Gln Leu Arg Asn Tyr Trp Asn Lys Thr Ile Ala Phe Thr Pro Ser Ser 
                325                 330                 335     


Gly Gly Asp Ile Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
            340                 345                 350         


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Tyr Ile Thr 
        355                 360                 365             


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Thr Gly 
    370                 375                 380                 


Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Glu Ser 
385                 390                 395                 400 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe Arg 
                405                 410                 415     


Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            420                 425                 430         


Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala 
        435                 440                 445             


Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Leu Gly Ala 
    450                 455                 460                 


Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
465                 470                 475                 480 


Ser Ile Thr Leu Thr Val Gln Val Arg Gln Leu Leu Ser Gly Ile Val 
                485                 490                 495     


Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 
            500                 505                 510         


Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu 
        515                 520                 525             


Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
    530                 535                 540                 


Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser 
545                 550                 555                 560 


Trp Ser Asn Lys Ser Tyr Glu Gln Ile Trp Asp Asn Met Thr Trp Leu 
                565                 570                 575     


Gln Trp Asp Lys Glu Val Ser Asn Tyr Thr Gln Met Ile Tyr Gln Leu 
            580                 585                 590         


Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu 
        595                 600                 605             


Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Arg 
    610                 615                 620                 


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
625                 630                 635                 640 


Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg 
                645                 650                 655     


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro Asn Pro Gly 
            660                 665                 670         


Gly Leu Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly 
        675                 680                 685             


Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp 
    690                 695                 700                 


Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp 
705                 710                 715                 720 


Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly His Ser Ser 
                725                 730                 735     


Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Ile Lys Tyr Leu Gly Asn 
            740                 745                 750         


Leu Leu Val Tyr Trp Gly Arg Glu Leu Lys Ile Ser Ala Ile Asn Leu 
        755                 760                 765             


Phe Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg Val Ile 
    770                 775                 780                 


Glu Ile Gly Gln Arg Ile Gly Arg Ala Ile Leu Asn Ile Pro Arg Arg 
785                 790                 795                 800 


Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
                805                 810 


<210>  16
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Arg Ala Lys Glu Thr Arg Arg Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu 
    130                 135                 140                 


Val Gln Asp Lys Met Lys Lys Ala Tyr Ala Phe Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Val Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
                245                 250                 255     


Ile Ile Ile Val Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Arg Gly Val Thr Ile Gly Pro Gly Arg Val 
        275                 280                 285             


Phe Tyr Thr Gly Glu Val Thr Gly Asp Ile Arg Gln Ala His Cys Asn 
    290                 295                 300                 


Val Ser Arg Thr Arg Trp Lys Asn Thr Leu Lys Gln Val Glu Ile Lys 
305                 310                 315                 320 


Leu Lys Glu Gln Phe Gly Asn Lys Thr Ile Asn Phe Ser Gln Pro Ser 
                325                 330                 335     


Gly Gly Asp Pro Glu Ile Val Leu His Ser Phe Asn Cys Gly Gly Glu 
            340                 345                 350         


Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn Thr Thr Leu Ile Thr 
        355                 360                 365             


Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
    370                 375                 380                 


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
385                 390                 395                 400 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Ile Phe Arg 
                405                 410                 415     


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            420                 425                 430         


Tyr Lys Val Val Gln Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala 
        435                 440                 445             


Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Thr Ile Gly 
    450                 455                 460                 


Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
465                 470                 475                 480 


Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
                485                 490                 495     


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
            500                 505                 510         


Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
        515                 520                 525             


Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp 
    530                 535                 540                 


Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr 
545                 550                 555                 560 


Ser Trp Ser Asn Lys Ser Leu Asn Asp Ile Trp Asp Asn Met Thr Trp 
                565                 570                 575     


Met Gln Trp Asp Arg Glu Ile Asn Asn Phe Thr Glu Tyr Ile Tyr Thr 
            580                 585                 590         


Leu Leu Glu Asn Ala Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
        595                 600                 605             


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser 
    610                 615                 620                 


Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu 
625                 630                 635                 640 


Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val 
                645                 650                 655     


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro Ala Arg 
            660                 665                 670         


Arg Glu Pro Asp Arg Pro Glu Gly Thr Glu Gly Glu Gly Gly Glu Arg 
        675                 680                 685             


Asp Lys Asp Arg Ser Val Arg Leu Val His Gly Phe Leu Ala Leu Ile 
    690                 695                 700                 


Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
705                 710                 715                 720 


Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg 
                725                 730                 735     


Gly Trp Glu Ile Leu Lys Tyr Trp Gly Asn Leu Leu Gln Tyr Trp Ser 
            740                 745                 750         


Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asp Ala Ile Ala Ile 
        755                 760                 765             


Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Val Gln Arg Ile 
    770                 775                 780                 


Phe Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu 
785                 790                 795                 800 


Arg Ala Leu Leu 
                


<210>  17
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Met Arg Val Lys Gly Ile Leu Arg Asn Trp Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Lys Cys Thr Glu Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Met Glu 
    130                 135                 140                 


Leu Arg Asp Arg Lys Gln Lys Val Asn Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Ile Val Pro Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Gln Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Ile Ile Val Arg Ser Glu Asn Leu Thr Asp Asn Val Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asp Lys Pro Val Gly Ile Val Cys Ile Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Lys Glu Ala Tyr Cys 
    290                 295                 300                 


Asn Ile Lys Glu Ser Glu Trp Asn Arg Thr Leu Gln Arg Val Gly Glu 
305                 310                 315                 320 


Lys Leu Gly Lys Tyr Phe Pro Ser Lys Thr Ile Lys Phe Asn Ser Ser 
                325                 330                 335     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Thr Tyr Ile Thr Leu 
        355                 360                 365             


Pro Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
    370                 375                 380                 


Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Gln Ser Asn 
385                 390                 395                 400 


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe Arg Pro 
                405                 410                 415     


Gly Gly Gly Asp Met Arg Asp Ser Trp Arg Ser Glu Leu Tyr Lys Tyr 
            420                 425                 430         


Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
        435                 440                 445             


Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val 
    450                 455                 460                 


Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
465                 470                 475                 480 


Ile Ala Leu Thr Ala Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln 
                485                 490                 495     


Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu 
            500                 505                 510         


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
        515                 520                 525             


Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys 
    530                 535                 540                 


Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp 
545                 550                 555                 560 


Ser Asn Lys Ser Lys Glu Asp Ile Trp Asn Asn Met Thr Trp Met Gln 
                565                 570                 575     


Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu 
            580                 585                 590         


Glu Asp Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala 
        595                 600                 605             


Leu Asp Ser Trp Lys Asn Leu Trp Thr Trp Phe Asp Ile Ser Asn Trp 
    610                 615                 620                 


Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
625                 630                 635                 640 


Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln 
                645                 650                 655     


Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Glu 
            660                 665                 670         


Leu Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg 
        675                 680                 685             


Asp Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp 
    690                 695                 700                 


Asp Leu Arg Ser Leu Cys Leu Phe Ser Cys His Arg Leu Arg Asp Cys 
705                 710                 715                 720 


Ile Leu Ile Ala Val Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu 
                725                 730                 735     


Lys Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu 
            740                 745                 750         


Val Gln Tyr Trp Cys Leu Glu Leu Lys Lys Ser Ala Thr Ser Leu Ile 
        755                 760                 765             


Asp Ala Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Asp 
    770                 775                 780                 


Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile 
785                 790                 795                 800 


Arg Gln Gly Phe Glu Ala Ala Leu Gln 
                805                 


<210>  18
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Met Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Val Pro Ile Glu Glu Asn Ser Asn Ser Ser Asn Ser Asn 
            180                 185                 190         


Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Ile Lys 
            340                 345                 350         


Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser 
        355                 360                 365             


Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asn Ile 
385                 390                 395                 400 


Asn Gly Thr Trp Asn Gly Thr Asn Gly Thr Thr Glu Ser Asn Asp Thr 
                405                 410                 415     


Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu 
            420                 425                 430         


Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys 
        435                 440                 445             


Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn 
    450                 455                 460                 


Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
                485                 490                 495     


Leu Gly Val Ala Pro Thr Lys Ala Lys Leu Thr Val Gln Ala Arg Gln 
            500                 505                 510         


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
        515                 520                 525             


Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
    530                 535                 540                 


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
545                 550                 555                 560 


Leu Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg 
                565                 570                 575     


Glu Ile Ser Asn Tyr Thr Asp Ile Ile Tyr Ser Leu Ile Glu Glu Ser 
            580                 585                 590         


Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys 
        595                 600                 605             


Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr 
    610                 615                 620                 


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
625                 630                 635                 640 


Val Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
                645                 650                 655     


Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro Asp Arg 
            660                 665                 670         


Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser 
        675                 680                 685             


Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
    690                 695                 700                 


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile 
705                 710                 715                 720 


Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu 
                725                 730                 735     


Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn 
            740                 745                 750         


Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly 
        755                 760                 765             


Thr Asp Arg Ile Ile Glu Val Val Gln Arg Ala Cys Arg Ala Ile Leu 
    770                 775                 780                 


His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu Pro 
785                 790                 795                 800 


<210>  19
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser 
            260                 265                 270         


Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn 
                325                 330                 335     


Asn Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr 
    370                 375                 380                 


Gln Leu Phe Asn Ser Thr Trp Asn Val Asn Gly Thr Trp Asn Gly Thr 
385                 390                 395                 400 


Gly Ser Glu Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asn Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Leu Thr Val 
                485                 490                 495     


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
            500                 505                 510         


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
        515                 520                 525             


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
    530                 535                 540                 


Lys Asp Gln Gln Leu Leu Glu Glu Ile Trp Asn Asn Met Thr Trp Met 
545                 550                 555                 560 


Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu 
                565                 570                 575     


Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 
            580                 585                 590         


Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn 
        595                 600                 605             


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
    610                 615                 620                 


Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg 
625                 630                 635                 640 


Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Leu Pro Ala Pro Arg 
                645                 650                 655     


Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln Gly 
            660                 665                 670         


Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ile Trp 
        675                 680                 685             


Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp 
    690                 695                 700                 


Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly 
705                 710                 715                 720 


Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln 
                725                 730                 735     


Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala 
            740                 745                 750         


Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp 
        755                 760                 765             


Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg 
    770                 775                 780                 


Ala Leu Leu 
785         


<210>  20
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Gly Ser Ser Lys Thr Asn Val 
    130                 135                 140                 


Ser Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Asn Ser Asn Ser Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Phe Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Ala Lys Lys Leu Lys 
            340                 345                 350         


Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ser Leu Asn Ser 
385                 390                 395                 400 


Ser Ala Pro Asp Asp Thr Glu Ser Asn Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Asn Lys Glu Thr Asn Glu 
    450                 455                 460                 


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Arg Ala Lys Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
            500                 505                 510         


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln 
        515                 520                 525             


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr 
    530                 535                 540                 


Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Asn 
545                 550                 555                 560 


Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser 
                565                 570                 575     


Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln 
            580                 585                 590         


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser 
        595                 600                 605             


Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile 
    610                 615                 620                 


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
625                 630                 635                 640 


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
                645                 650                 655     


Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg 
            660                 665                 670         


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu 
        675                 680                 685             


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
    690                 695                 700                 


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg 
705                 710                 715                 720 


Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly 
                725                 730                 735     


Trp Glu Gly Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu 
            740                 745                 750         


Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala 
        755                 760                 765             


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Ile Gln Arg Ile Cys 
    770                 775                 780                 


Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg 
785                 790                 795                 800 


Ala Leu Leu 
            


<210>  21
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr Tyr Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Ala Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Asn Thr Arg Asn Ser Thr Asn Thr Val Asn 
    130                 135                 140                 


Asn Thr Met Asn Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr 
145                 150                 155                 160 


Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile Ser 
            180                 185                 190         


Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
            260                 265                 270         


Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser 
        275                 280                 285             


Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Val 
    290                 295                 300                 


Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
305                 310                 315                 320 


Asn Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Gln Trp Asn Asn 
                325                 330                 335     


Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asn Asp Thr Arg Leu Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Asn Ser Thr Glu Gly Ser Asp Asn Thr Gly Gly Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Ser 
    450                 455                 460                 


Ser Asn Asn Asn Asn Asp Thr Glu Ile Phe Arg Pro Gly Gly Gly Asn 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Asn Glu Leu Tyr Lys Tyr Lys Val Val Gln 
                485                 490                 495     


Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Leu Thr Val Gln 
            500                 505                 510         


Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
        515                 520                 525             


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
    530                 535                 540                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Arg 
545                 550                 555                 560 


Asp Gln Gln Leu Leu Glu Glu Ile Trp Asn Asn Met Thr Trp Met Glu 
                565                 570                 575     


Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile 
            580                 585                 590         


Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
        595                 600                 605             


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp 
    610                 615                 620                 


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly 
625                 630                 635                 640 


Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Lys 
                645                 650                 655     


Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala Pro Arg Gly 
            660                 665                 670         


Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg 
        675                 680                 685             


Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu Ala Leu Ile Trp Asp 
    690                 695                 700                 


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu 
705                 710                 715                 720 


Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp 
                725                 730                 735     


Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu 
            740                 745                 750         


Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val 
        755                 760                 765             


Ala Glu Gly Thr Asp Arg Val Ile Glu Val Val Gln Arg Ala Cys Arg 
    770                 775                 780                 


Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala 
785                 790                 795                 800 


Leu Leu 
        


<210>  22
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg 
                165                 170                 175     


Leu Asp Ile Val Pro Leu Asn Glu Ser Asn Ser Asn Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile 
            260                 265                 270         


Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His 
        275                 280                 285             


Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys Lys Leu Ala Glu His 
            340                 345                 350         


Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Asn Ser Thr Trp Asn Asn Thr Ser Thr Trp 
385                 390                 395                 400 


Asn Asp Asn Gly Asn Asp Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Val Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Ile Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Leu 
                485                 490                 495     


Thr Val Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln Gln Gln Ser 
            500                 505                 510         


Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr 
        515                 520                 525             


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg 
    530                 535                 540                 


Tyr Leu Lys Asp Gln Gln Leu Leu Asn Glu Ile Trp Asp Asn Met Thr 
545                 550                 555                 560 


Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr 
                565                 570                 575     


Arg Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
            580                 585                 590         


Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile 
        595                 600                 605             


Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly 
    610                 615                 620                 


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg 
625                 630                 635                 640 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn 
                645                 650                 655     


Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu 
            660                 665                 670         


Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Phe Leu Ala Leu 
        675                 680                 685             


Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr His Arg Leu 
    690                 695                 700                 


Arg Asp Leu Ile Leu Ile Ala Ala Arg Ala Val Glu Leu Leu Gly Arg 
705                 710                 715                 720 


Ser Ser Leu Arg Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu 
                725                 730                 735     


Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile 
            740                 745                 750         


Ser Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
        755                 760                 765             


Ile Ile Glu Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile Pro 
    770                 775                 780                 


Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
785                 790                 795     


<210>  23
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Val Asn Asn Ile Thr Asn Val 
    130                 135                 140                 


Pro Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Asp Asn Gly Lys Asn Asp Ser 
            180                 185                 190         


Thr Asn Thr Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Thr Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Ser Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala 
305                 310                 315                 320 


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys 
                325                 330                 335     


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Thr Glu 
            340                 345                 350         


Lys Leu Lys Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Gly Thr Asp Arg Val Gln Glu Ser Asn Ser Thr Glu Ser Asn Asp Thr 
                405                 410                 415     


Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg 
            420                 425                 430         


Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Ser Gly Arg Ile Asn Cys 
        435                 440                 445             


Val Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Asn Thr 
    450                 455                 460                 


Asn Glu Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu 
                485                 490                 495     


Gly Ile Ala Pro Thr Lys Ala Lys Leu Thr Val Gln Ala Arg Gln Leu 
            500                 505                 510         


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
        515                 520                 525             


Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
    530                 535                 540                 


Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
545                 550                 555                 560 


Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu 
                565                 570                 575     


Ile Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln 
            580                 585                 590         


Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp 
        595                 600                 605             


Lys Asn Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile 
    610                 615                 620                 


Arg Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile 
625                 630                 635                 640 


Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
                645                 650                 655     


Leu Ser Leu Gln Thr Pro Thr His His Gln Arg Glu Pro Asp Arg Pro 
            660                 665                 670         


Glu Arg Ile Glu Glu Gly Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile 
        675                 680                 685             


Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Asn 
    690                 695                 700                 


Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala 
705                 710                 715                 720 


Ala Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg 
                725                 730                 735     


Leu Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Leu Tyr Trp 
            740                 745                 750         


Gly Gln Glu Leu Lys Asn Ser Ala Ile Ser Leu Leu Asn Thr Thr Ala 
        755                 760                 765             


Ile Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu Val Ala Gln Arg 
    770                 775                 780                 


Ala Trp Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu 
785                 790                 795                 800 


Glu Arg Leu Leu Leu 
                805 


<210>  24
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Ser Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Ile Asn Asn Ile Thr Asn Val 
    130                 135                 140                 


Pro Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Asn Asn Lys Ser Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Lys Gln Ala Cys 
        195                 200                 205             


Pro Lys Ile Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Lys Asn Val Ser Ser Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn 
    290                 295                 300                 


Asn Thr Arg Thr Ser Ile Thr Ile Gly Pro Gly Gln Val Phe Tyr Arg 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Gly Val Leu Lys Gln Val Thr Glu Lys Leu Lys 
            340                 345                 350         


Glu His Phe Lys Asn Lys Thr Ile Ile Phe Gln Pro Pro Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Met His His Phe Asn Cys Arg Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Thr Gln Leu Phe Asn Asn Thr Cys Ile Gly Asn Glu 
385                 390                 395                 400 


Thr Ile Glu Gly Cys Lys Asn Ile Thr Leu Pro Cys Lys Ile Lys Gln 
                405                 410                 415     


Thr Ile Asn Met Trp Gln Gly Ala Gly Gln Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Ser Gly Arg Ile Asn Cys Val Ser Asn Ile Thr Gly Ile Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Val Asn Asn Thr Asn Asn Glu Thr Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asn Ile Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
            500                 505                 510         


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
        515                 520                 525             


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
    530                 535                 540                 


Arg Tyr Leu Lys Asp Gln Lys Phe Leu Glu Glu Ile Trp Asn Asn Met 
545                 550                 555                 560 


Thr Trp Ile Glu Trp Glu Arg Glu Ile Ser Asn Tyr Thr Asn Gln Ile 
                565                 570                 575     


Tyr Glu Ile Leu Thr Glu Ser Gln Asn Gln Gln Asp Arg Asn Glu Lys 
            580                 585                 590         


Asp Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
        595                 600                 605             


Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
    610                 615                 620                 


Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn 
625                 630                 635                 640 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Pro Thr His 
                645                 650                 655     


His Gln Arg Glu Pro Asp Arg Pro Glu Arg Ile Glu Glu Gly Gly Gly 
            660                 665                 670         


Glu Gln Gly Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu Ala 
        675                 680                 685             


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
    690                 695                 700                 


Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly 
705                 710                 715                 720 


Arg Ser Ser Leu Lys Gly Leu Arg Arg Gly Trp Glu Gly Leu Lys Tyr 
                725                 730                 735     


Leu Gly Asn Leu Leu Leu Tyr Trp Gly Gln Glu Leu Lys Ile Ser Ala 
            740                 745                 750         


Ile Ser Leu Phe Asn Ala Thr Ala Ile Ala Val Ala Gly Trp Thr Asp 
        755                 760                 765             


Arg Val Ile Glu Val Ala Gln Gly Thr Trp Arg Ala Ile Leu His Ile 
    770                 775                 780                 


Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Gln 
785                 790                 795         


<210>  25
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Arg Ala Lys Glu Thr Arg Arg Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Leu Asn Asn Val Thr Tyr Val Asn Ile Thr Glu 
    130                 135                 140                 


Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Val Gln 
145                 150                 155                 160 


Asp Lys Met Lys Lys Ala Tyr Ala Phe Phe Tyr Arg Leu Asp Val Val 
                165                 170                 175     


Pro Ile Asp Asp Asn His Gly Asn Ser Ser Ser Asn Ser Ser Ser Asn 
            180                 185                 190         


Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro 
225                 230                 235                 240 


Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val 
            260                 265                 270         


Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Ile Ile Ile Val 
        275                 280                 285             


Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg Pro Asn Asn Asn 
    290                 295                 300                 


Thr Arg Arg Gly Val Thr Ile Gly Pro Gly Arg Val Phe Tyr Thr Gly 
305                 310                 315                 320 


Glu Val Thr Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Thr 
                325                 330                 335     


Arg Trp Lys Asn Thr Leu Lys Gln Val Glu Ile Lys Leu Lys Glu Gln 
            340                 345                 350         


Phe Gly Asn Lys Thr Ile Asn Phe Ser Gln Pro Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Val Leu His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Asn Thr Thr Leu Leu Asn Asp Thr Ala Glu 
385                 390                 395                 400 


Ser Asn Asp Asn Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asn Asp Asn Asn Thr Asp Asn Thr Thr Glu Ile Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Gln Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
            500                 505                 510         


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
        515                 520                 525             


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
    530                 535                 540                 


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Asn Asp Ile Trp Asp Asn Met 
545                 550                 555                 560 


Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Phe Thr Glu Tyr Ile 
                565                 570                 575     


Tyr Thr Leu Leu Glu Asn Ala Gln Asn Gln Gln Glu Lys Asn Glu Gln 
            580                 585                 590         


Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
        595                 600                 605             


Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
    610                 615                 620                 


Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn 
625                 630                 635                 640 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro 
                645                 650                 655     


Ala Arg Arg Glu Pro Asp Arg Pro Glu Gly Thr Glu Gly Glu Gly Gly 
            660                 665                 670         


Glu Arg Asp Lys Asp Arg Ser Val Arg Leu Val His Gly Phe Leu Ala 
        675                 680                 685             


Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
    690                 695                 700                 


Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly 
705                 710                 715                 720 


Arg Arg Gly Trp Glu Ile Leu Lys Tyr Trp Gly Asn Leu Leu Gln Tyr 
                725                 730                 735     


Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asp Ala Ile 
            740                 745                 750         


Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Val Gln 
        755                 760                 765             


Arg Ile Phe Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln Gly 
    770                 775                 780                 


Leu Glu Arg Ala Leu Leu 
785                 790 


<210>  26
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Met Arg Val Arg Gly Thr Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Val Leu Gly Phe Trp Met Leu Met Ile Cys Asn Gly Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Leu Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Ser Arg Asn Val Ser Ser Tyr Asn Thr Tyr Asn 
    130                 135                 140                 


Gly Ser Val Glu Glu Ile Lys Asn Cys Ser Phe Asn Ala Thr Pro Glu 
145                 150                 155                 160 


Val Arg Asp Arg Lys Gln Arg Met Tyr Ala Leu Phe Tyr Gly Leu Asp 
                165                 170                 175     


Ile Val Pro Leu Asn Lys Lys Asn Ser Ser Glu Asn Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile 
            260                 265                 270         


Ile Arg Ser Glu Asn Leu Thr Asn Asn Val Lys Thr Ile Ile Val His 
        275                 280                 285             


Leu Asn Gln Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Asp 
                325                 330                 335     


Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys Lys Leu Ala Glu His 
            340                 345                 350         


Phe His Asn Lys Thr Ile Lys Phe Ala Ser Ser Ser Gly Gly Asp Leu 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Ser Gly Leu Phe Asn Gly Thr Tyr Met Pro Thr Tyr Met Pro 
385                 390                 395                 400 


Asn Gly Thr Glu Ser Asn Ser Asn Ser Thr Ile Thr Ile Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Thr Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Leu Leu Val His Asp Gly Gly Ile Lys Glu Asn Asp Thr Glu Asn 
    450                 455                 460                 


Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Ala Ala Lys Leu Thr Ala Gln Ala Arg Gln Leu Leu 
            500                 505                 510         


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
        515                 520                 525             


Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
    530                 535                 540                 


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
545                 550                 555                 560 


Ser Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Asp Arg Glu Val 
                565                 570                 575     


Ser Asn Tyr Thr Asn Ile Ile Tyr Ser Leu Leu Glu Glu Ser Gln Asn 
            580                 585                 590         


Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys 
        595                 600                 605             


Asn Leu Trp Ser Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
    610                 615                 620                 


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
625                 630                 635                 640 


Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
                645                 650                 655     


Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly 
            660                 665                 670         


Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser Ile Arg 
        675                 680                 685             


Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Asn Leu 
    690                 695                 700                 


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Ser Val Ala Ala 
705                 710                 715                 720 


Arg Val Val Glu Leu Leu Gly Arg Ser Ser Trp Glu Ala Leu Lys Tyr 
                725                 730                 735     


Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala 
            740                 745                 750         


Ile Ser Leu Phe Asp Ser Ile Ala Ile Val Val Ala Glu Gly Thr Asp 
        755                 760                 765             


Arg Ile Ile Glu Leu Val Gln Gly Phe Cys Arg Ala Ile Arg Asn Ile 
    770                 775                 780                 


Pro Thr Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
785                 790                 795         


<210>  27
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr Tyr Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Ala Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser 
    130                 135                 140                 


Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Val Val Pro Ile Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Leu Ser Arg Ala Gln Trp Asn Asn Thr Leu Lys Gln Ile Val Ile 
305                 310                 315                 320 


Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser 
                325                 330                 335     


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val 
    370                 375                 380                 


Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Ile Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Asn Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
        435                 440                 445             


Ala Lys Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln 
    450                 455                 460                 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
465                 470                 475                 480 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala 
                485                 490                 495     


Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Glu Ile Trp Asn Asn 
            500                 505                 510         


Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu 
        515                 520                 525             


Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Val Gly Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val 
            580                 585                 590         


Asn Arg Val Arg Lys Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu 
        595                 600                 605             


Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly 
    610                 615                 620                 


Gly Glu Gln Gly Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu 
            660                 665                 670         


Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln 
        675                 680                 685             


Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala 
    690                 695                 700                 


Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Val 
705                 710                 715                 720 


Gln Arg Ala Cys Arg Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln 
                725                 730                 735     


Gly Leu Glu Arg Ala Leu Leu 
            740             


<210>  28
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Ile Val Pro Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Ile Ser Arg Ala Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys 
305                 310                 315                 320 


Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro Ser 
                325                 330                 335     


Ser Gly Gly Asp Pro Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Ile Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp Gln Glu Val 
    370                 375                 380                 


Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Glu Thr Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg 
        435                 440                 445             


Ala Lys Leu Thr Val Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln 
    450                 455                 460                 


Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu 
465                 470                 475                 480 


Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
                485                 490                 495     


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asn Thr 
        515                 520                 525             


Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe 
545                 550                 555                 560 


Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile 
            580                 585                 590         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr 
        595                 600                 605             


Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly 
    610                 615                 620                 


Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Leu Ile Leu Ile Ala Ala Arg Ala Val Glu Leu Leu 
            660                 665                 670         


Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys 
        675                 680                 685             


Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser 
    690                 695                 700                 


Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr 
705                 710                 715                 720 


Asp Arg Ile Ile Glu Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn 
                725                 730                 735     


Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
            740                 745                 750 


<210>  29
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Glu Val Arg Asn Cys Ser Phe Asn Met Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Ile Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Thr Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Ser Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys 
    290                 295                 300                 


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Thr Glu 
305                 310                 315                 320 


Lys Leu Lys Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser 
                325                 330                 335     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ile 
        355                 360                 365             


Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val 
    370                 375                 380                 


Gly Gln Ala Met Tyr Ala Pro Pro Ile Ser Gly Arg Ile Asn Cys Val 
385                 390                 395                 400 


Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe 
                405                 410                 415     


Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr 
            420                 425                 430         


Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Lys 
        435                 440                 445             


Ala Lys Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
    450                 455                 460                 


Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu 
465                 470                 475                 480 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala 
                485                 490                 495     


Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
        515                 520                 525             


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val 
            580                 585                 590         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Pro Thr 
        595                 600                 605             


His His Gln Arg Glu Pro Asp Arg Pro Glu Arg Ile Glu Glu Gly Gly 
    610                 615                 620                 


Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ala Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu 
            660                 665                 670         


Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys 
        675                 680                 685             


Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly Gln Glu Leu Lys Asn Ser 
    690                 695                 700                 


Ala Ile Ser Leu Leu Asn Thr Thr Ala Ile Ala Val Ala Gly Trp Thr 
705                 710                 715                 720 


Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp Arg Ala Ile Leu His 
                725                 730                 735     


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu Leu 
            740                 745                 750 


<210>  30
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Pro Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Ile Ile Leu Gly Leu Ile Met Ile Cys Ser Asn Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Lys Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Gly Glu Met Lys Asn Cys Ser Tyr Asn Met Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Lys Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Val Val Gln Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Arg Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Val Arg Ile Arg Ser Glu Asn Ile Ser Asp Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val Gln Leu Thr Glu Pro Val Thr Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly Pro Gly Gln Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Val Ser Ser Ser Lys Trp Asn Lys Thr Leu Gln Gln Val Val Thr 
305                 310                 315                 320 


Gln Leu Arg Asn Tyr Trp Asn Lys Thr Ile Ala Phe Thr Pro Ser Ser 
                325                 330                 335     


Gly Gly Asp Ile Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
            340                 345                 350         


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Tyr Ile Thr 
        355                 360                 365             


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Thr Gly 
    370                 375                 380                 


Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Glu Ser 
385                 390                 395                 400 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe Arg 
                405                 410                 415     


Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            420                 425                 430         


Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala 
        435                 440                 445             


Lys Leu Thr Val Gln Val Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    450                 455                 460                 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys 
465                 470                 475                 480 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                485                 490                 495     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Gln Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Leu Gln Trp Asp Lys Glu Val Ser Asn Tyr Thr Gln Met 
        515                 520                 525             


Ile Tyr Gln Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Thr Arg Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile 
            580                 585                 590         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr 
        595                 600                 605             


Pro Asn Pro Gly Gly Leu Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly 
    610                 615                 620                 


Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu 
            660                 665                 670         


Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Ile Lys 
        675                 680                 685             


Tyr Leu Gly Asn Leu Leu Val Tyr Trp Gly Arg Glu Leu Lys Ile Ser 
    690                 695                 700                 


Ala Ile Asn Leu Phe Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr 
705                 710                 715                 720 


Asp Arg Val Ile Glu Ile Gly Gln Arg Ile Gly Arg Ala Ile Leu Asn 
                725                 730                 735     


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
            740                 745                 750 


<210>  31
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Met Arg Ala Lys Glu Thr Arg Arg Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu 
    130                 135                 140                 


Val Gln Asp Lys Met Lys Lys Ala Tyr Ala Phe Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Val Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
                245                 250                 255     


Ile Ile Ile Val Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Arg Gly Val Thr Ile Gly Pro Gly Arg Val 
        275                 280                 285             


Phe Tyr Thr Gly Glu Val Thr Gly Asp Ile Arg Gln Ala His Cys Asn 
    290                 295                 300                 


Val Ser Arg Thr Arg Trp Lys Asn Thr Leu Lys Gln Val Glu Ile Lys 
305                 310                 315                 320 


Leu Lys Glu Gln Phe Gly Asn Lys Thr Ile Asn Phe Ser Gln Pro Ser 
                325                 330                 335     


Gly Gly Asp Pro Glu Ile Val Leu His Ser Phe Asn Cys Gly Gly Glu 
            340                 345                 350         


Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn Thr Thr Leu Ile Thr 
        355                 360                 365             


Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
    370                 375                 380                 


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
385                 390                 395                 400 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Ile Phe Arg 
                405                 410                 415     


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            420                 425                 430         


Tyr Lys Val Val Gln Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala 
        435                 440                 445             


Lys Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    450                 455                 460                 


Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
465                 470                 475                 480 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                485                 490                 495     


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Asn Asp Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Phe Thr Glu Tyr 
        515                 520                 525             


Ile Tyr Thr Leu Leu Glu Asn Ala Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val 
            580                 585                 590         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu 
        595                 600                 605             


Pro Ala Arg Arg Glu Pro Asp Arg Pro Glu Gly Thr Glu Gly Glu Gly 
    610                 615                 620                 


Gly Glu Arg Asp Lys Asp Arg Ser Val Arg Leu Val His Gly Phe Leu 
625                 630                 635                 640 


Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
                645                 650                 655     


Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu 
            660                 665                 670         


Gly Arg Arg Gly Trp Glu Ile Leu Lys Tyr Trp Gly Asn Leu Leu Gln 
        675                 680                 685             


Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asp Ala 
    690                 695                 700                 


Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Val 
705                 710                 715                 720 


Gln Arg Ile Phe Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln 
                725                 730                 735     


Gly Leu Glu Arg Ala Leu Leu 
            740             


<210>  32
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Arg Val Lys Gly Ile Leu Arg Asn Trp Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Lys Cys Thr Glu Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Met Glu 
    130                 135                 140                 


Leu Arg Asp Arg Lys Gln Lys Val Asn Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Ile Val Pro Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Gln Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Ile Ile Val Arg Ser Glu Asn Leu Thr Asp Asn Val Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asp Lys Pro Val Gly Ile Val Cys Ile Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Lys Glu Ala Tyr Cys 
    290                 295                 300                 


Asn Ile Lys Glu Ser Glu Trp Asn Arg Thr Leu Gln Arg Val Gly Glu 
305                 310                 315                 320 


Lys Leu Gly Lys Tyr Phe Pro Ser Lys Thr Ile Lys Phe Asn Ser Ser 
                325                 330                 335     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Thr Tyr Ile Thr Leu 
        355                 360                 365             


Pro Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
    370                 375                 380                 


Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Gln Ser Asn 
385                 390                 395                 400 


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe Arg Pro 
                405                 410                 415     


Gly Gly Gly Asp Met Arg Asp Ser Trp Arg Ser Glu Leu Tyr Lys Tyr 
            420                 425                 430         


Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
        435                 440                 445             


Leu Thr Ala Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln Gln Gln 
    450                 455                 460                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
465                 470                 475                 480 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu 
                485                 490                 495     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Asp Ile Trp Asn Asn Met 
            500                 505                 510         


Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn Thr Ile 
        515                 520                 525             


Tyr Arg Leu Leu Glu Asp Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys 
    530                 535                 540                 


Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Thr Trp Phe Asp 
545                 550                 555                 560 


Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly 
                565                 570                 575     


Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn 
            580                 585                 590         


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro 
        595                 600                 605             


Asn Pro Arg Glu Leu Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly 
    610                 615                 620                 


Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala 
625                 630                 635                 640 


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Cys His Arg 
                645                 650                 655     


Leu Arg Asp Cys Ile Leu Ile Ala Val Arg Ala Val Glu Leu Leu Gly 
            660                 665                 670         


Arg Ser Ser Leu Lys Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr 
        675                 680                 685             


Leu Gly Ser Leu Val Gln Tyr Trp Cys Leu Glu Leu Lys Lys Ser Ala 
    690                 695                 700                 


Thr Ser Leu Ile Asp Ala Ile Ala Ile Ala Val Ala Glu Gly Thr Asp 
705                 710                 715                 720 


Arg Ile Ile Asp Leu Ile Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile 
                725                 730                 735     


Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
            740                 745                 


<210>  33
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Met Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Val Pro Ile Glu Glu Asn Ser Asn Ser Ser Asn Ser Asn 
            180                 185                 190         


Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Ile Lys 
            340                 345                 350         


Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser 
        355                 360                 365             


Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asn Ile 
385                 390                 395                 400 


Asn Gly Thr Trp Asn Gly Thr Asn Gly Thr Thr Glu Ser Asn Asp Thr 
                405                 410                 415     


Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu 
            420                 425                 430         


Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys 
        435                 440                 445             


Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn 
    450                 455                 460                 


Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
                485                 490                 495     


Leu Gly Val Ala Pro Thr Lys Ala Lys Leu Thr Val Gln Ala Arg Gln 
            500                 505                 510         


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
        515                 520                 525             


Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
    530                 535                 540                 


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
545                 550                 555                 560 


Leu Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg 
                565                 570                 575     


Glu Ile Ser Asn Tyr Thr Asp Ile Ile Tyr Ser Leu Ile Glu Glu Ser 
            580                 585                 590         


Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys 
        595                 600                 605             


Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr 
    610                 615                 620                 


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
625                 630                 635                 640 


Val Phe Ala Val Leu Ser Ile 
                645         


<210>  34
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser 
            260                 265                 270         


Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile His Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn 
                325                 330                 335     


Asn Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr 
    370                 375                 380                 


Gln Leu Phe Asn Ser Thr Trp Asn Val Asn Gly Thr Trp Asn Gly Thr 
385                 390                 395                 400 


Gly Ser Glu Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asn Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Leu Thr Val 
                485                 490                 495     


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
            500                 505                 510         


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
        515                 520                 525             


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
    530                 535                 540                 


Lys Asp Gln Gln Leu Leu Glu Glu Ile Trp Asn Asn Met Thr Trp Met 
545                 550                 555                 560 


Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu 
                565                 570                 575     


Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 
            580                 585                 590         


Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn 
        595                 600                 605             


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
    610                 615                 620                 


Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
625                 630                 635 


<210>  35
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Gly Ser Ser Lys Thr Asn Val 
    130                 135                 140                 


Ser Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Asn Ser Asn Ser Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Phe Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Ala Lys Lys Leu Lys 
            340                 345                 350         


Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ser Leu Asn Ser 
385                 390                 395                 400 


Ser Ala Pro Asp Asp Thr Glu Ser Asn Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Asn Lys Glu Thr Asn Glu 
    450                 455                 460                 


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Arg Ala Lys Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
            500                 505                 510         


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln 
        515                 520                 525             


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr 
    530                 535                 540                 


Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Asn 
545                 550                 555                 560 


Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser 
                565                 570                 575     


Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln 
            580                 585                 590         


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser 
        595                 600                 605             


Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile 
    610                 615                 620                 


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
625                 630                 635                 640 


Val Leu Ser Ile 
                


<210>  36
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr Tyr Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Ala Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Asn Thr Arg Asn Ser Thr Asn Thr Val Asn 
    130                 135                 140                 


Asn Thr Met Asn Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr 
145                 150                 155                 160 


Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile Ser 
            180                 185                 190         


Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
            260                 265                 270         


Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser 
        275                 280                 285             


Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Val 
    290                 295                 300                 


Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
305                 310                 315                 320 


Asn Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Gln Trp Asn Asn 
                325                 330                 335     


Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asn Asp Thr Arg Leu Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Asn Ser Thr Glu Gly Ser Asp Asn Thr Gly Gly Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Ser 
    450                 455                 460                 


Ser Asn Asn Asn Asn Asp Thr Glu Ile Phe Arg Pro Gly Gly Gly Asn 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Asn Glu Leu Tyr Lys Tyr Lys Val Val Gln 
                485                 490                 495     


Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Leu Thr Val Gln 
            500                 505                 510         


Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
        515                 520                 525             


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
    530                 535                 540                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Arg 
545                 550                 555                 560 


Asp Gln Gln Leu Leu Glu Glu Ile Trp Asn Asn Met Thr Trp Met Glu 
                565                 570                 575     


Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile 
            580                 585                 590         


Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
        595                 600                 605             


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp 
    610                 615                 620                 


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly 
625                 630                 635                 640 


Leu Arg Ile Val Phe Thr Val Leu Ser Ile 
                645                 650 


<210>  37
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Trp 
    130                 135                 140                 


Glu Thr Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg 
                165                 170                 175     


Leu Asp Ile Val Pro Leu Asn Glu Ser Asn Ser Asn Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile 
            260                 265                 270         


Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His 
        275                 280                 285             


Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys Lys Leu Ala Glu His 
            340                 345                 350         


Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Asn Ser Thr Trp Asn Asn Thr Ser Thr Trp 
385                 390                 395                 400 


Asn Asp Asn Gly Asn Asp Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Val Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Ile Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Leu 
                485                 490                 495     


Thr Val Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln Gln Gln Ser 
            500                 505                 510         


Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr 
        515                 520                 525             


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg 
    530                 535                 540                 


Tyr Leu Lys Asp Gln Gln Leu Leu Asn Glu Ile Trp Asp Asn Met Thr 
545                 550                 555                 560 


Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr 
                565                 570                 575     


Arg Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
            580                 585                 590         


Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile 
        595                 600                 605             


Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly 
    610                 615                 620                 


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
625                 630                 635         


<210>  38
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Val Asn Asn Ile Thr Asn Val 
    130                 135                 140                 


Pro Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Asp Asn Gly Lys Asn Asp Ser 
            180                 185                 190         


Thr Asn Thr Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Thr Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Ser Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala 
305                 310                 315                 320 


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys 
                325                 330                 335     


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Lys Gln Val Thr Glu 
            340                 345                 350         


Lys Leu Lys Glu His Phe Asn Asn Lys Thr Ile Ile Phe Asn Ser Ser 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Gly Thr Asp Arg Val Gln Glu Ser Asn Ser Thr Glu Ser Asn Asp Thr 
                405                 410                 415     


Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg 
            420                 425                 430         


Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Ser Gly Arg Ile Asn Cys 
        435                 440                 445             


Val Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Asn Thr 
    450                 455                 460                 


Asn Glu Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu 
                485                 490                 495     


Gly Ile Ala Pro Thr Lys Ala Lys Leu Thr Val Gln Ala Arg Gln Leu 
            500                 505                 510         


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
        515                 520                 525             


Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
    530                 535                 540                 


Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
545                 550                 555                 560 


Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu 
                565                 570                 575     


Ile Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln 
            580                 585                 590         


Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp 
        595                 600                 605             


Lys Asn Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile 
    610                 615                 620                 


Arg Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile 
625                 630                 635                 640 


Phe Ala Val Leu Ser Ile 
                645     


<210>  39
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Ser Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Thr Asn Ile Asn Asn Ile Thr Asn Val 
    130                 135                 140                 


Pro Asn Ile Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Asp Asn Asn Lys Ser Ser 
            180                 185                 190         


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Lys Gln Ala Cys 
        195                 200                 205             


Pro Lys Ile Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Lys Asn Val Ser Ser Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn 
    290                 295                 300                 


Asn Thr Arg Thr Ser Ile Thr Ile Gly Pro Gly Gln Val Phe Tyr Arg 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Gly Val Leu Lys Gln Val Thr Glu Lys Leu Lys 
            340                 345                 350         


Glu His Phe Lys Asn Lys Thr Ile Ile Phe Gln Pro Pro Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Met His His Phe Asn Cys Arg Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Asn Thr Thr Gln Leu Phe Asn Asn Thr Cys Ile Gly Asn Glu 
385                 390                 395                 400 


Thr Ile Glu Gly Cys Lys Asn Ile Thr Leu Pro Cys Lys Ile Lys Gln 
                405                 410                 415     


Thr Ile Asn Met Trp Gln Gly Ala Gly Gln Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Ser Gly Arg Ile Asn Cys Val Ser Asn Ile Thr Gly Ile Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Val Asn Asn Thr Asn Asn Glu Thr Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asn Ile Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
            500                 505                 510         


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
        515                 520                 525             


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
    530                 535                 540                 


Arg Tyr Leu Lys Asp Gln Lys Phe Leu Glu Glu Ile Trp Asn Asn Met 
545                 550                 555                 560 


Thr Trp Ile Glu Trp Glu Arg Glu Ile Ser Asn Tyr Thr Asn Gln Ile 
                565                 570                 575     


Tyr Glu Ile Leu Thr Glu Ser Gln Asn Gln Gln Asp Arg Asn Glu Lys 
            580                 585                 590         


Asp Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
        595                 600                 605             


Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
    610                 615                 620                 


Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
625                 630                 635             


<210>  40
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Met Arg Ala Lys Glu Thr Arg Arg Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Leu Asn Asn Val Thr Tyr Val Asn Ile Thr Glu 
    130                 135                 140                 


Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Val Gln 
145                 150                 155                 160 


Asp Lys Met Lys Lys Ala Tyr Ala Phe Phe Tyr Arg Leu Asp Val Val 
                165                 170                 175     


Pro Ile Asp Asp Asn His Gly Asn Ser Ser Ser Asn Ser Ser Ser Asn 
            180                 185                 190         


Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro 
225                 230                 235                 240 


Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val 
            260                 265                 270         


Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Ile Ile Ile Val 
        275                 280                 285             


Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg Pro Asn Asn Asn 
    290                 295                 300                 


Thr Arg Arg Gly Val Thr Ile Gly Pro Gly Arg Val Phe Tyr Thr Gly 
305                 310                 315                 320 


Glu Val Thr Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Thr 
                325                 330                 335     


Arg Trp Lys Asn Thr Leu Lys Gln Val Glu Ile Lys Leu Lys Glu Gln 
            340                 345                 350         


Phe Gly Asn Lys Thr Ile Asn Phe Ser Gln Pro Ser Gly Gly Asp Pro 
        355                 360                 365             


Glu Ile Val Leu His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Asn Thr Thr Leu Leu Asn Asp Thr Ala Glu 
385                 390                 395                 400 


Ser Asn Asp Asn Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asn Asp Asn Asn Thr Asp Asn Thr Thr Glu Ile Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Gln Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
            500                 505                 510         


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
        515                 520                 525             


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
    530                 535                 540                 


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Asn Asp Ile Trp Asp Asn Met 
545                 550                 555                 560 


Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Phe Thr Glu Tyr Ile 
                565                 570                 575     


Tyr Thr Leu Leu Glu Asn Ala Gln Asn Gln Gln Glu Lys Asn Glu Gln 
            580                 585                 590         


Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
        595                 600                 605             


Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
    610                 615                 620                 


Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
625                 630                 635             


<210>  41
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Met Arg Val Arg Gly Thr Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Val Leu Gly Phe Trp Met Leu Met Ile Cys Asn Gly Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Leu Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Ser Arg Asn Val Ser Ser Tyr Asn Thr Tyr Asn 
    130                 135                 140                 


Gly Ser Val Glu Glu Ile Lys Asn Cys Ser Phe Asn Ala Thr Pro Glu 
145                 150                 155                 160 


Val Arg Asp Arg Lys Gln Arg Met Tyr Ala Leu Phe Tyr Gly Leu Asp 
                165                 170                 175     


Ile Val Pro Leu Asn Lys Lys Asn Ser Ser Glu Asn Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile 
            260                 265                 270         


Ile Arg Ser Glu Asn Leu Thr Asn Asn Val Lys Thr Ile Ile Val His 
        275                 280                 285             


Leu Asn Gln Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Asp 
                325                 330                 335     


Lys Trp Asn Glu Thr Leu Gln Arg Val Gly Lys Lys Leu Ala Glu His 
            340                 345                 350         


Phe His Asn Lys Thr Ile Lys Phe Ala Ser Ser Ser Gly Gly Asp Leu 
        355                 360                 365             


Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Ser Gly Leu Phe Asn Gly Thr Tyr Met Pro Thr Tyr Met Pro 
385                 390                 395                 400 


Asn Gly Thr Glu Ser Asn Ser Asn Ser Thr Ile Thr Ile Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Thr Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Leu Leu Val His Asp Gly Gly Ile Lys Glu Asn Asp Thr Glu Asn 
    450                 455                 460                 


Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Ala Ala Lys Leu Thr Ala Gln Ala Arg Gln Leu Leu 
            500                 505                 510         


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
        515                 520                 525             


Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
    530                 535                 540                 


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
545                 550                 555                 560 


Ser Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Asp Arg Glu Val 
                565                 570                 575     


Ser Asn Tyr Thr Asn Ile Ile Tyr Ser Leu Leu Glu Glu Ser Gln Asn 
            580                 585                 590         


Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys 
        595                 600                 605             


Asn Leu Trp Ser Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
    610                 615                 620                 


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
625                 630                 635                 640 


Ala Val Leu Ser Ile 
                645 


<210>  42
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Pro Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Ile Ile Leu Gly Leu Ile Met Ile Cys Ser Asn Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Lys Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Gly Glu Met Lys Asn Cys Ser Tyr Asn Met Thr Thr Glu 
    130                 135                 140                 


Leu Arg Asp Lys Lys Lys Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Val Val Gln Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Arg Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Val Arg Ile Arg Ser Glu Asn Ile Ser Asp Asn Ala Lys 
                245                 250                 255     


Thr Ile Ile Val Gln Leu Thr Glu Pro Val Thr Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly Pro Gly Gln Ala 
        275                 280                 285             


Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
    290                 295                 300                 


Asn Val Ser Ser Ser Lys Trp Asn Lys Thr Leu Gln Gln Val Val Thr 
305                 310                 315                 320 


Gln Leu Arg Asn Tyr Trp Asn Lys Thr Ile Ala Phe Thr Pro Ser Ser 
                325                 330                 335     


Gly Gly Asp Ile Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
            340                 345                 350         


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Tyr Ile Thr 
        355                 360                 365             


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Thr Gly 
    370                 375                 380                 


Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Glu Ser 
385                 390                 395                 400 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe Arg 
                405                 410                 415     


Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            420                 425                 430         


Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala 
        435                 440                 445             


Lys Leu Thr Val Gln Val Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    450                 455                 460                 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys 
465                 470                 475                 480 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                485                 490                 495     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Gln Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Leu Gln Trp Asp Lys Glu Val Ser Asn Tyr Thr Gln Met 
        515                 520                 525             


Ile Tyr Gln Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Thr Arg Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
            580                 585                 590     


<210>  43
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Met Arg Ala Lys Glu Thr Arg Arg Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu 
    130                 135                 140                 


Val Gln Asp Lys Met Lys Lys Ala Tyr Ala Phe Phe Tyr Arg Leu Asp 
145                 150                 155                 160 


Val Val Pro Ile Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
                245                 250                 255     


Ile Ile Ile Val Gln Leu Asn Glu Ser Val Val Ile Asn Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Arg Gly Val Thr Ile Gly Pro Gly Arg Val 
        275                 280                 285             


Phe Tyr Thr Gly Glu Val Thr Gly Asp Ile Arg Gln Ala His Cys Asn 
    290                 295                 300                 


Val Ser Arg Thr Arg Trp Lys Asn Thr Leu Lys Gln Val Glu Ile Lys 
305                 310                 315                 320 


Leu Lys Glu Gln Phe Gly Asn Lys Thr Ile Asn Phe Ser Gln Pro Ser 
                325                 330                 335     


Gly Gly Asp Pro Glu Ile Val Leu His Ser Phe Asn Cys Gly Gly Glu 
            340                 345                 350         


Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn Thr Thr Leu Ile Thr 
        355                 360                 365             


Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
    370                 375                 380                 


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
385                 390                 395                 400 


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Ile Phe Arg 
                405                 410                 415     


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            420                 425                 430         


Tyr Lys Val Val Gln Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala 
        435                 440                 445             


Lys Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    450                 455                 460                 


Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
465                 470                 475                 480 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                485                 490                 495     


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Asn Asp Ile Trp Asp Asn 
            500                 505                 510         


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Phe Thr Glu Tyr 
        515                 520                 525             


Ile Tyr Thr Leu Leu Glu Asn Ala Gln Asn Gln Gln Glu Lys Asn Glu 
    530                 535                 540                 


Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
545                 550                 555                 560 


Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                565                 570                 575     


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
            580                 585                 590     


<210>  44
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Met Arg Val Lys Gly Ile Leu Arg Asn Trp Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Lys Cys Thr Glu Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Met Glu 
    130                 135                 140                 


Leu Arg Asp Arg Lys Gln Lys Val Asn Ala Leu Phe Tyr Lys Leu Asp 
145                 150                 155                 160 


Ile Val Pro Leu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
        195                 200                 205             


Gly Thr Gly Pro Cys Gln Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Gly Glu Ile Ile Val Arg Ser Glu Asn Leu Thr Asp Asn Val Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asp Lys Pro Val Gly Ile Val Cys Ile Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Lys Glu Ala Tyr Cys 
    290                 295                 300                 


Asn Ile Lys Glu Ser Glu Trp Asn Arg Thr Leu Gln Arg Val Gly Glu 
305                 310                 315                 320 


Lys Leu Gly Lys Tyr Phe Pro Ser Lys Thr Ile Lys Phe Asn Ser Ser 
                325                 330                 335     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly 
            340                 345                 350         


Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Thr Tyr Ile Thr Leu 
        355                 360                 365             


Pro Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
    370                 375                 380                 


Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Gln Ser Asn 
385                 390                 395                 400 


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Thr Phe Arg Pro 
                405                 410                 415     


Gly Gly Gly Asp Met Arg Asp Ser Trp Arg Ser Glu Leu Tyr Lys Tyr 
            420                 425                 430         


Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
        435                 440                 445             


Leu Thr Ala Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln Gln Gln 
    450                 455                 460                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
465                 470                 475                 480 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu 
                485                 490                 495     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Glu Asp Ile Trp Asn Asn Met 
            500                 505                 510         


Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn Thr Ile 
        515                 520                 525             


Tyr Arg Leu Leu Glu Asp Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys 
    530                 535                 540                 


Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Thr Trp Phe Asp 
545                 550                 555                 560 


Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly 
                565                 570                 575     


Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
            580                 585                 590 


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Cys Arg Gly Asp Cys 
1               5   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide



<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Cys Xaa Cys Arg Gly Asp Cys Xaa Cys 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Cys Asp Cys Arg Gly Asp Cys Phe Cys 
1               5                   


