                         SEQUENCE LISTING

<110>  Ablynx N.V.
 
<120>  AMINO ACID SEQUENCES DIRECTED AGAINST CELLULAR RECEPTORS FOR 
       VIRUSES AND BACTERIA

<130>  P08-023-PCT-1

<160>  311   

<170>  PatentIn version 3.4

<210>  1
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Pro Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Asp Ser Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Arg Cys Tyr Phe Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  2
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  2

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Arg Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Leu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Thr Ala Ser 
    50                  55                  60                  


Asn Arg Gly Tyr Leu His Met Asn Asn Leu Thr Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  3
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  3

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Leu Thr Gly Gly Ala Phe Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Thr Pro Gly Arg Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Asn Met Val Tyr Leu Arg Met Asn Ser Leu Ile Pro Glu Asp Ala Ala 
65                  70                  75                  80  


Val Tyr Ser Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Leu Val Thr Val Ser Ser 
            100         


<210>  4
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ser Pro Phe Arg Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Thr Ser Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys 
    50                  55                  60                  


Asn Thr Val Trp Leu His Gly Ser Thr Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  5
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  5

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Gly Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Glu Arg Ile Phe Asp Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Tyr Arg Gln Gly Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Met Asp Tyr Thr Lys 
    50                  55                  60                  


Gln Thr Val Tyr Leu His Met Asn Ser Leu Arg Pro Glu Asp Thr Gly 
65                  70                  75                  80  


Leu Tyr Tyr Cys Lys Ile Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  6
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  6

Asp Val Lys Phe Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Asn Phe Asp Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ser Glu Lys Asp Lys 
    50                  55                  60                  


Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Leu Tyr Ile Cys Ala Gly Xaa Xaa Xaa Xaa Xaa Trp Gly Arg Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  7
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  7

Gln Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Thr Tyr Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Tyr Arg Gln Tyr Pro Gly Lys Gln Arg Ala Leu Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ala Arg Asp Ser Thr Lys 
    50                  55                  60                  


Asp Thr Phe Cys Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Tyr Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  8
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Pro Arg Glu Gly Val 
        35                  40                  45              


Ser Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys 
    50                  55                  60                  


Asn Thr Val His Leu Leu Met Asn Arg Val Asn Ala Glu Asp Thr Ala 
65                  70                  75                  80  


Leu Tyr Tyr Cys Ala Val Xaa Xaa Xaa Xaa Xaa Trp Gly Arg Gly Thr 
                85                  90                  95      


Arg Val Thr Val Ser Ser 
            100         


<210>  9
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Asp Ile Ser Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Tyr Arg Gln Val Pro Gly Lys Leu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys 
    50                  55                  60                  


Arg Ala Ile Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Asn Arg Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Pro 
            100         


<210>  10
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  10

Gln Val Pro Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Phe Cys Ala Val Pro Ser Phe Thr Ser Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asn Ala Thr Lys 
    50                  55                  60                  


Asn Thr Leu Thr Leu Arg Met Asp Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  11
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Phe Cys Thr Val Ser Gly Gly Thr Ala Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Glu Lys Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ala Arg Glu Asn Ala Gly 
    50                  55                  60                  


Asn Met Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala 
65                  70                  75                  80  


Leu Tyr Thr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Arg Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  12
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  12

Ala Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Gln Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Asn Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Val Phe Leu 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys 
    50                  55                  60                  


Asn Met Met Tyr Leu Gln Met Asn Asn Leu Lys Pro Gln Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  13
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  13

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Leu Thr Ser Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Thr Pro Trp Gln Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys 
    50                  55                  60                  


Asp Thr Val Leu Leu Glu Met Asn Phe Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Ile Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  14
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  14

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Thr Arg Thr Leu Asp Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Arg Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Val Ser Arg Asp Ser Ala Glu 
    50                  55                  60                  


Asn Thr Val Ala Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Arg Val Thr Val Ser Ser 
            100         


<210>  15
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Arg Leu Thr Ala His Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Tyr Ala Gly 
    50                  55                  60                  


Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Gly 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Thr Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  16
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Glu Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Arg Asn Phe Val Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Val Ser Arg Asp Asn Gly Lys 
    50                  55                  60                  


Asn Thr Ala Tyr Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Ala Val Xaa Xaa Xaa Xaa Xaa Leu Gly Ser Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  17
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  17

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Val Leu Glu Trp Val 
        35                  40                  45              


Ser Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Val Lys Xaa Xaa Xaa Xaa Xaa Gly Ser Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  18
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Cys Val Ser Ser Gly Cys Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Ala Glu Glu Trp Val 
        35                  40                  45              


Ser Xaa Xaa Xaa Xaa Xaa Arg Phe Lys Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Gly Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Met Tyr Tyr Cys Gln Arg Xaa Xaa Xaa Xaa Xaa Arg Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  19
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Phe Ser Gly Ser Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg His Thr Pro Gly Lys Ala Glu Glu Trp Val 
        35                  40                  45              


Ser Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu Ser Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Met Tyr Tyr Cys Gly Arg Xaa Xaa Xaa Xaa Xaa Arg Ser Lys Gly Ile 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  20
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  20

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Ala Xaa Xaa Xaa Xaa Xaa Arg Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  21
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  21

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Leu Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Asn Met Leu Tyr Leu His Leu Asn Asn Leu Lys Ser Glu Asp Thr Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Arg Arg Xaa Xaa Xaa Xaa Xaa Leu Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  22
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  CDR

<220>
<221>  misc_feature
<222>  (50)..(54)
<223>  CDR

<220>
<221>  misc_feature
<222>  (87)..(91)
<223>  CDR

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Cys Val Ser Ser Gly Cys Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Ala Glu Glu Trp Val 
        35                  40                  45              


Ser Xaa Xaa Xaa Xaa Xaa Arg Phe Lys Ile Ser Arg Asp Asn Ala Lys 
    50                  55                  60                  


Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Gly Pro Glu Asp Thr Ala 
65                  70                  75                  80  


Met Tyr Tyr Cys Gln Arg Xaa Xaa Xaa Xaa Xaa Arg Gly Gln Gly Thr 
                85                  90                  95      


Gln Val Thr Val Ser Ser 
            100         


<210>  23
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  23

Gln Val Gln Arg Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  25

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Arg Ala Phe Gly 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  26

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Arg Asp Phe Val 
            20                  25                  30  


<210>  27
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Leu Gly Arg Thr Ala Gly 
            20                  25                  30  


<210>  28
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Thr Ile Leu Ser 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Thr Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Val Ala Ser Gly Asn Thr Phe Asn 
            20                  25                  30  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ser Ala Pro Gly Phe Thr Leu Asp 
            20                  25                  30  


<210>  31
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  31

Ala Gln Glu Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn 
            20                  25                  30  


<210>  32
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  32

Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly 
            20          


<210>  33
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  33

Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Lys Leu 
1               5                   10                  15      


Ser Cys Ala Leu Thr Gly 
            20          


<210>  34
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  34

Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly 
            20          


<210>  35
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  35

Val Asp Ser Gly Gly Gly Leu Val Glu Ala Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Gln Val Ser Glu 
            20          


<210>  36
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  36

Gln Asp Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Lys Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly 
            20          


<210>  37
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  37

Val Gln Ser Gly Gly Arg Leu Val Gln Ala Gly Asp Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Glu 
            20          


<210>  38
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  38

Val Glu Ser Gly Gly Thr Leu Val Gln Ser Gly Asp Ser Leu Lys Leu 
1               5                   10                  15      


Ser Cys Ala Ser Ser Thr 
            20          


<210>  39
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  39

Met Glu Ser Gly Gly Asp Ser Val Gln Ser Gly Gly Ser Leu Thr Leu 
1               5                   10                  15      


Ser Cys Val Ala Ser Gly 
            20          


<210>  40
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW1 sequence

<400>  40

Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ser Ala Ser Val 
            20          


<210>  41
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  41

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  42

Trp Phe Arg Gln Thr Pro Gly Arg Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  43

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val Ala 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  44

Trp Tyr Arg Gln Gly Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  45

Trp Ile Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  46

Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  47

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Asp Leu Val Ala 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  48

Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Glu Val Ser 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW2 sequence

<400>  49

Trp Phe Arg Gln Pro Pro Gly Lys Val Arg Glu Phe Val Gly 
1               5                   10                  


<210>  50
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  50

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Arg Cys Tyr Phe 
            20                  25                  30          


<210>  51
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  51

Arg Phe Ala Ile Ser Arg Asp Asn Asn Lys Asn Thr Gly Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  52
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  52

Arg Phe Thr Val Ala Arg Asn Asn Ala Lys Asn Thr Val Asn Leu Glu 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  53
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  53

Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Asp Leu Leu 
1               5                   10                  15      


Met Asn Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  54
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  54

Arg Leu Thr Ile Ser Arg Asp Asn Ala Val Asp Thr Met Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  55
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  55

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asp Asn Val Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  56
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  56

Arg Phe Thr Ile Ser Lys Asp Ser Gly Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  57
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  57

Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Met Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  58
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  58

Arg Phe Thr Ile Ser Arg Glu Asn Asp Lys Ser Thr Val Tyr Leu Gln 
1               5                   10                  15      


Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  59
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW3 sequence

<400>  59

Arg Phe Thr Ile Ser Arg Asp Tyr Ala Gly Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  60
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW4 sequence

<400>  60

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW4 sequence

<400>  61

Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW4 sequence

<400>  62

Arg Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  KERE-class Nanobody FW4 sequence

<400>  63

Trp Gly Leu Gly Thr Gln Val Thr Ile Ser Ser 
1               5                   10      


<210>  64
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  65
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  65

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Ile Phe Lys 
            20                  25                  30  


<210>  66
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  66

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  67
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Cys Val Ser Ser Gly Cys Thr 
            20                  25                  30  


<210>  68
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Phe Ser Gly Ser Thr Phe Ser 
            20                  25                  30  


<210>  69
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  69

Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly 
            20          


<210>  70
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  70

Glu Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Val Ala Ser Gly 
            20          


<210>  71
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW1 sequence

<400>  71

Val Glu Ser Gly Gly Gly Leu Ala Leu Pro Gly Gly Ser Leu Thr Leu 
1               5                   10                  15      


Ser Cys Val Phe Ser Gly 
            20          


<210>  72
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  72

Trp Val Arg Gln Ala Pro Gly Lys Val Leu Glu Trp Val Ser 
1               5                   10                  


<210>  73
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  73

Trp Val Arg Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  74
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  74

Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  75

Trp Val Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp Val Ser 
1               5                   10                  


<210>  76
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  76

Trp Val Arg Gln Ala Pro Gly Lys Asp Gln Glu Trp Val Ser 
1               5                   10                  


<210>  77
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  77

Trp Val Arg Gln Ala Pro Gly Lys Ala Glu Glu Trp Val Ser 
1               5                   10                  


<210>  78
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  78

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  79
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW2 sequence

<400>  79

Trp Val Arg Gln Ala Pro Gly Arg Ala Thr Glu Trp Val Ser 
1               5                   10                  


<210>  80
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW3 sequence

<400>  80

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  81
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW3 sequence

<400>  81

Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asp Ser Leu Ile Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  82
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW3 sequence

<400>  82

Arg Phe Thr Ser Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  83
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW3 sequence

<400>  83

Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Gly Pro Glu Asp Thr Ala Met Tyr Tyr Cys Gln Arg 
            20                  25                  30          


<210>  84
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW3 sequence

<400>  84

Arg Phe Thr Ala Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Arg Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  85
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW3 sequence

<400>  85

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asp Asp Leu Gln Ser Glu Asp Thr Ala Met Tyr Tyr Cys Gly Arg 
            20                  25                  30          


<210>  86
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW4 sequence

<400>  86

Gly Ser Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW4 sequence

<400>  87

Leu Arg Gly Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  88
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW4 sequence

<400>  88

Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  89
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW4 sequence

<400>  89

Arg Ser Arg Gly Ile Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW4 sequence

<400>  90

Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  91
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  GLEW-class Nanobody FW4 sequence

<400>  91

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  92
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  92

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  93
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Gly 
            20                  25                  30  


<210>  94
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  94

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Ile Phe Lys 
            20                  25                  30  


<210>  95
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  95

Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Thr Ile Val Ser 
            20                  25                  30  


<210>  96
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  96

Gln Glu His Leu Val Glu Ser Gly Gly Gly Leu Val Asp Ile Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Ile Phe Ser 
            20                  25                  30  


<210>  97
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  97

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  98
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Cys Val Ser Ser Gly Cys Thr 
            20                  25                  30  


<210>  99
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Phe Ser Gly Ser Thr Phe Ser 
            20                  25                  30  


<210>  100
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  100

Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly 
            20          


<210>  101
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW1 sequence

<400>  101

Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Arg 
            20          


<210>  102
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  102

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  103
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  103

Trp Val Arg Gln Ala Pro Gly Lys Val Leu Glu Trp Val Ser 
1               5                   10                  


<210>  104
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  104

Trp Val Arg Arg Pro Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  105
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  105

Trp Ile Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  106
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  106

Trp Val Arg Gln Tyr Pro Gly Lys Glu Pro Glu Trp Val Ser 
1               5                   10                  


<210>  107
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  107

Trp Phe Arg Gln Pro Pro Gly Lys Glu His Glu Phe Val Ala 
1               5                   10                  


<210>  108
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  108

Trp Tyr Arg Gln Ala Pro Gly Lys Arg Thr Glu Leu Val Ala 
1               5                   10                  


<210>  109
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  109

Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  110
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  110

Trp Leu Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  111
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW2 sequence

<400>  111

Trp Val Arg Gln Ala Pro Gly Lys Ala Glu Glu Phe Val Ser 
1               5                   10                  


<210>  112
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  112

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  113
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  113

Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asp Ser Leu Ile Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  114
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  114

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Met Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Thr Glu Asp Thr Gly Val Tyr Trp Cys Gly Ala 
            20                  25                  30          


<210>  115
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  115

Arg Phe Thr Ile Ser Ser Asp Ser Asn Arg Asn Met Ile Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  116
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  116

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu His 
1               5                   10                  15      


Leu Asn Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Arg 
            20                  25                  30          


<210>  117
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  117

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu Arg 
1               5                   10                  15      


Leu Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn Leu 
            20                  25                  30          


<210>  118
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  118

Arg Phe Lys Ile Ser Arg Asp Asn Ala Lys Lys Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Gly Pro Glu Asp Thr Ala Met Tyr Tyr Cys Gln Arg 
            20                  25                  30          


<210>  119
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW3 sequence

<400>  119

Arg Phe Thr Val Ser Arg Asp Asn Gly Lys Asn Thr Ala Tyr Leu Arg 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Ala Val 
            20                  25                  30          


<210>  120
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW4 sequence

<400>  120

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW4 sequence

<400>  121

Leu Arg Gly Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW4 sequence

<400>  122

Gly Asn Lys Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  123
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW4 sequence

<400>  123

Ser Ser Pro Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  124
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW4 sequence

<400>  124

Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  125
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  P,R,S 103-class Nanobody FW4 sequence

<400>  125

Arg Ser Arg Gly Ile Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  126
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  127
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  127

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn 
            20                  25                  30  


<210>  128
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  128

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30  


<210>  129
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  130
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Thr Ser Gly Arg Pro Leu Leu 
            20                  25                  30  


<210>  131
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  131

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Glu 
            20                  25                  30  


<210>  132
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Thr Ser Gly Arg Pro Leu Leu 
            20                  25                  30  


<210>  133
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser 
            20                  25                  30  


<210>  134
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  135
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Ala 
            20                  25                  30  


<210>  136
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser 
            20                  25                  30  


<210>  137
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Pro Leu Arg Leu Thr Cys Glu Ala Ser Gly Val Ile Tyr Ser 
            20                  25                  30  


<210>  138
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Phe Thr Arg Asp 
            20                  25                  30  


<210>  139
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Ile Gly Asn 
            20                  25                  30  


<210>  140
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn 
            20                  25                  30  


<210>  141
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Phe Phe Ser 
            20                  25                  30  


<210>  142
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  142

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  143
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  143

Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  144
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  144

Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser 
1               5                   10                  


<210>  145
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  145

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  146
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  146

Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  147
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  147

Trp Phe Arg Lys Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  148
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  148

Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  149
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  149

Trp Tyr Arg Gln Gly Pro Gly Lys Glu Arg Asp Phe Val Ala 
1               5                   10                  


<210>  150
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  150

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  151
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  151

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Thr 
1               5                   10                  


<210>  152
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  152

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  153
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  153

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  154
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  154

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  155
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  155

Trp Leu Arg Gln Ala Pro Gly Lys Glu Leu Glu Gly Val Ser 
1               5                   10                  


<210>  156
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  156

Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  157
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  157

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  158
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  158

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Gln 
1               5                   10                  15      


Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  159
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  159

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala 
            20                  25                  30          


<210>  160
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  160

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  161
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  161

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Glu Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  162
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  162

Arg Phe Thr Ile Ser Gly His Asn Ala Lys Asn Thr Val Ser Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  163
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  163

Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln 
            20                  25                  30          


<210>  164
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  164

Arg Phe Thr Ile Ser Gly His Asn Ala Lys Asn Thr Val Ser Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  165
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  165

Arg Phe Thr Ile Ser Arg Asp Thr Ala Asn Tyr Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Leu 
            20                  25                  30          


<210>  166
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  166

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  167
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  167

Arg Phe Thr Leu Thr Arg Asp Asn Gly Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asp Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Phe Cys Ala Ala 
            20                  25                  30          


<210>  168
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  168

Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val 
            20                  25                  30          


<210>  169
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  169

Arg Phe Thr Ile Ser Gly Asp Asn Arg Lys Lys Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ile 
            20                  25                  30          


<210>  170
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  170

Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu 
            20                  25                  30          


<210>  171
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  171

Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val 
            20                  25                  30          


<210>  172
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  172

Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala 
            20                  25                  30          


<210>  173
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  173

Arg Phe Thr Ile Ser Arg Asp Asn Tyr Asn Thr Val Tyr Leu Gln Met 
1               5                   10                  15      


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
            20                  25                  30      


<210>  174
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  174

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  175
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  175

Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  176
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  176

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  177
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  177

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  178
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  178

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  179
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  179

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  180
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  180

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  181
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  181

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  182
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  182

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  183
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  183

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  184
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  184

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  185
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  185

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  186

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  187
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  187

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  188
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  188

Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  189
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  189

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  190
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  190

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  191
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ala 
            20                  25                  30  


<210>  192
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Ser Ile Leu Asp 
            20                  25                  30  


<210>  193
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn 
            20                  25                  30  


<210>  194
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  194

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  195
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  195

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  196
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  196

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val Thr 
1               5                   10                  


<210>  197
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  197

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  198
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  198

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  199
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  199

Arg Phe Thr Ile Ala Arg Gly Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Gly 
            20                  25                  30          


<210>  200
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  200

Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  201
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  201

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  202
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  202

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  203
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  203

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  204
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  204

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  205
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Framework sequence

<400>  205

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  206
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  206

Ser Tyr Ala Met Ser 
1               5   


<210>  207
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  207

Asn Tyr Ala Met Gly 
1               5   


<210>  208
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  208

Ile His Thr Met Ser 
1               5   


<210>  209
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  209

Asp Tyr Ala Met Ser 
1               5   


<210>  210
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  210

Gly Tyr Thr Ile Ala 
1               5   


<210>  211
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  211

Asp Tyr Ala Ile Gly 
1               5   


<210>  212
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  212

Gly Tyr Thr Ile Ala 
1               5   


<210>  213
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  213

Pro Ser Ala Met Ala 
1               5   


<210>  214
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  214

Asp Tyr Ala Met Ser 
1               5   


<210>  215
<211>  2
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  215

Met Gly 
1       


<210>  216
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  216

Leu Asn Ala Met Gly 
1               5   


<210>  217
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  217

Val Asn Asp Met Gly 
1               5   


<210>  218
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  218

Tyr Tyr Thr Ile Gly 
1               5   


<210>  219
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  219

Tyr His Ala Ile Val 
1               5   


<210>  220
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  220

Asn Tyr Ala Met Gly 
1               5   


<210>  221
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  221

Ile Asn Ala Met Gly 
1               5   


<210>  222
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  222

Gly Tyr Trp Met Tyr 
1               5   


<210>  223
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  223

Ser Tyr Ser Met Gly 
1               5   


<210>  224
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  224

Phe Asn Ala Met Gly 
1               5   


<210>  225
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 sequence

<400>  225

Val Met Gly 
1           


<210>  226
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  226

Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  227
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  227

Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr Gly 
1               5                   10                  15      


Asp Ser Val Lys Asp 
            20      


<210>  228
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  228

Thr Ile Lys Pro Ser Gly Asp Thr Thr Asn Tyr Ala Asn Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  229
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  229

Ala Ile Ser Trp Asn Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  230
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  230

Tyr His Arg Trp Ser Asp Gly Ala Asn Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  231
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  231

Cys Ile Ser Gly Ser Asp Gly Ser Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  232
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  232

Tyr His Arg Trp Ser Asp Gly Ala Asn Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  233
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  233

Ser Thr Ile Trp Ser Arg Gly Asp Thr Tyr Phe Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  234
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  234

Ala Ile Ser Trp Asn Gly Gly Ser Ala Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  235
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  235

Thr Ser Arg Leu Ile Thr Asp Asn Ile Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  236
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  236

Gly Ile Thr Ser Ser Thr Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  237
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  237

Val Ile Thr Ser Gly Gly Gly Thr Asn Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  238
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  238

Cys Ile Ser Ser Ser Asp Gly Ser Thr Ala Tyr Leu Gly Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  239
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  239

Cys Ile Thr Ser Arg Asp Ser Ile Thr Tyr Tyr Ala Ser Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  240
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  240

Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr Gly 
1               5                   10                  15      


Asp Ser Val Lys Asp 
            20      


<210>  241
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  241

Ser Ile Thr Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  242
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  242

Ala Ile Ser Pro Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  243
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  243

Ala Ile Ser Trp Ser Gly Asp Glu Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  244
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  244

Thr Ile Ala Arg Ala Gly Ala Thr Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  245
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 sequence

<400>  245

Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp 
1               5                   10                  15      


Ser Val Lys Ser 
            20  


<210>  246
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  246

Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn 
1               5                   10              


<210>  247
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  247

Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  248
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  248

Asp Tyr Phe Gly Thr Gly Val 
1               5           


<210>  249
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  249

Asp Gln Gly Pro Phe Tyr Ser Gly Thr Tyr Tyr Tyr Thr Arg Gln Tyr 
1               5                   10                  15      


Gly Tyr 
        


<210>  250
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  250

Ala Arg Met Thr Thr Ser Asn Asp Lys Glu Tyr Leu Tyr 
1               5                   10              


<210>  251
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  251

Gln Tyr Gly Val Gly Gly Arg Val Val Cys Pro Gly Pro Tyr Glu Tyr 
1               5                   10                  15      


Asp Val 
        


<210>  252
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  252

Ala Trp Met Thr Thr Ser Asn Asp Lys Glu Tyr Leu Tyr 
1               5                   10              


<210>  253
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  253

Arg Val Arg Pro Tyr Gly Gln Tyr Asp Tyr 
1               5                   10  


<210>  254
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  254

Asp Gln Gly Pro Phe Tyr Ser Gly Thr Tyr Tyr Tyr Thr Lys Gly Tyr 
1               5                   10                  15      


Ala Tyr 
        


<210>  255
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  255

Arg Gln Asn Tyr Ser Arg Ser Val Phe Gly Ala Lys Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  256
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  256

Asp Cys Pro Asp Tyr Tyr Ser Asp Tyr Glu Cys Pro Leu Glu Asp 
1               5                   10                  15  


<210>  257
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  257

Tyr Tyr Ser Ser Gly Ile Ser Thr Leu Arg Ser 
1               5                   10      


<210>  258
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  258

Asx Ser Ala Asp Ser Arg Cys Ser Ile Gly Ser Ile Gly Phe Thr Trp 
1               5                   10                  15      


Leu Tyr Asn Asn 
            20  


<210>  259
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  259

Asx Thr Ser Met Thr Cys Pro Thr Leu Ile Val Arg Phe Asn Tyr 
1               5                   10                  15  


<210>  260
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  260

Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  261
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  261

Asp Gly Val Pro Glu Trp Gly Lys Val Gln Tyr Pro Asp Thr Tyr 
1               5                   10                  15  


<210>  262
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  262

Ser Leu Thr Ala Thr His Thr Tyr Glu Tyr Asp Tyr 
1               5                   10          


<210>  263
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  263

Asp Arg Trp Trp Arg Pro Ala Gly Leu Gln Trp Asp Tyr 
1               5                   10              


<210>  264
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  264

Arg Val Phe Asp Leu Pro Asn Asp Tyr 
1               5                   


<210>  265
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 sequence

<400>  265

Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr Asp Phe 
1               5                   10                  15  


<210>  266
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  266

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  267
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  267

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  268
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  268

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile His 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Lys Pro Ser Gly Asp Thr Thr Asn Tyr Ala Asn Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Tyr Phe Gly Thr Gly Val Arg Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  269
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  269

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Asn Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Pro Phe Tyr Ser Gly Thr Tyr Tyr Tyr Thr Arg 
            100                 105                 110         


Gln Tyr Gly Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  270
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  270

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Thr Ser Gly Arg Pro Leu Leu Gly Tyr 
            20                  25                  30          


Thr Ile Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr His Arg Trp Ser Asp Gly Ala Asn Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly His Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Met Thr Thr Ser Asn Asp Lys Glu Tyr Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  271
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  271

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Lys Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Ser Asp Gly Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Gln Tyr Gly Val Gly Gly Arg Val Val Cys Pro Gly Pro Tyr 
            100                 105                 110         


Glu Tyr Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  272
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  272

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Thr Ser Gly Arg Pro Leu Leu Gly Tyr 
            20                  25                  30          


Thr Ile Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr His Arg Trp Ser Asp Gly Ala Asn Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly His Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Trp Met Thr Thr Ser Asn Asp Lys Glu Tyr Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  273
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  273

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Pro Ser 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Gly Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ser Thr Ile Trp Ser Arg Gly Asp Thr Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Asn Tyr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Leu Arg Val Arg Pro Tyr Gly Gln Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  274
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  274

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Asn Gly Gly Ser Ala Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Gly Pro Phe Tyr Ser Gly Thr Tyr Tyr Tyr Thr Lys 
            100                 105                 110         


Gly Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  275
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  275

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Ala Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Thr Thr Ser 
        35                  40                  45              


Arg Leu Ile Thr Asp Asn Ile Ile Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Leu Thr Arg Asp Asn Gly Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asp Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Phe Cys Ala Ala Arg 
                85                  90                  95      


Gln Asn Tyr Ser Arg Ser Val Phe Gly Ala Lys Asp Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  276
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  276

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ser Thr Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asp Cys Pro Asp Tyr Tyr Ser Asp Tyr Glu Cys Pro Leu Glu Asp 
            100                 105                 110         


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  277
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  277

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Pro Leu Arg Leu Thr Cys Glu Ala Ser Gly Val Ile Tyr Ser Val Asn 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Thr Ser Gly Gly Gly Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Arg Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ile Tyr Tyr Ser Ser Gly Ile Ser Thr Leu Arg Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  278
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  278

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Phe Thr Arg Asp Tyr Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ala Tyr Leu Gly Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asx Ser Ala Asp Ser Arg Cys Ser Ile Gly Ser Ile Gly Phe 
            100                 105                 110         


Thr Trp Leu Tyr Asn Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  279
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  279

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Ile Gly Asn Tyr His 
            20                  25                  30          


Ala Ile Val Trp Leu Arg Gln Ala Pro Gly Lys Glu Leu Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Thr Ser Arg Asp Ser Ile Thr Tyr Tyr Ala Ser Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Asx Thr Ser Met Thr Cys Pro Thr Leu Ile Val Arg Phe Asn 
            100                 105                 110         


Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  280
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  280

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Val Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  281
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  281

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Phe Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Asp Gly Val Pro Glu Trp Gly Lys Val Gln Tyr Pro Asp Thr Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  282
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  282

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr 
            180                 185                 190         


Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Met Leu Tyr Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr 
225                 230                 235                 240 


Tyr Asp Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210>  283
<211>  276
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  283

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                165                 170                 175     


Phe Asn Asn Tyr Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Phe Val Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val 
        195                 200                 205             


Ser Ala Ile Tyr Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly 
                245                 250                 255     


Ala Leu Arg Arg Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser 
        275     


<210>  284
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  284

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Met Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Arg Thr Phe Asn Asn Tyr Ala Met Gly Trp Phe Arg Arg 
                165                 170                 175     


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Thr Arg Ser Gly 
            180                 185                 190         


Val Arg Ser Gly Val Ser Ala Ile Tyr Gly Asp Ser Val Lys Asp Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala Ser 
225                 230                 235                 240 


Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu Tyr Asp Tyr Ser Gly 
                245                 250                 255     


Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265 


<210>  285
<211>  270
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  285

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Ala Met 
                165                 170                 175     


Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
            180                 185                 190         


Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr Gly Asp 
        195                 200                 205             


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu 
                245                 250                 255     


Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270 


<210>  286
<211>  269
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  286

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr Ala Ile 
                165                 170                 175     


Gly Trp Phe Arg Lys Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys 
            180                 185                 190         


Ile Ser Gly Ser Asp Gly Ser Thr Thr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gln 
225                 230                 235                 240 


Gln Tyr Gly Val Gly Gly Arg Val Val Cys Pro Gly Pro Tyr Glu Tyr 
                245                 250                 255     


Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 


<210>  287
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  287

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Thr Ser Gly Arg Pro Leu Leu Gly Tyr Thr Ile 
                165                 170                 175     


Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val Ala Tyr 
            180                 185                 190         


His Arg Trp Ser Asp Gly Ala Asn Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Gly His Asn Ala Lys Asn Thr Val Ser Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
225                 230                 235                 240 


Ala Arg Met Thr Thr Ser Asn Asp Lys Glu Tyr Leu Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Gln Val Thr Val Ser Ser 
            260                 


<210>  288
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  288

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Leu Thr Ala Thr His Thr Tyr Glu Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  289
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  289

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ala Ser Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Asp Glu Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Gly Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Arg Trp Trp Arg Pro Ala Gly Leu Gln Trp Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  290
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  290

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Ser Ile Leu Asp Phe Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Thr Thr Ile Ala Arg Ala Gly Ala Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Val Phe Asp Leu Pro Asn Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  291
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Nanobody sequence

<400>  291

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  292
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Glu Gly Ile Ser Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr 
1               5                   10                  15      


Ser Asp Asn Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met 
            20                  25                  30          


Lys Glu Pro Cys Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe 
        35                  40                  45              


Leu Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn 
    50                  55                  60                  


Gly Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met 
65                  70                  75                  80  


Thr Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val 
                85                  90                  95      


Ile Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe 
            100                 105                 110         


Gly Asn Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu 
        115                 120                 125             


Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu 
    130                 135                 140                 


Ala Ile Val His Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala 
145                 150                 155                 160 


Glu Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr 
                165                 170                 175     


Ile Pro Asp Phe Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr 
            180                 185                 190         


Ile Cys Asp Arg Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln 
        195                 200                 205             


Phe Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu 
    210                 215                 220                 


Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His 
225                 230                 235                 240 


Gln Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe 
                245                 250                 255     


Phe Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe 
            260                 265                 270         


Ile Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val 
        275                 280                 285             


His Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys 
    290                 295                 300                 


Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser 
305                 310                 315                 320 


Ala Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile 
                325                 330                 335     


Leu Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser 
            340                 345                 350         


Glu Ser Ser Ser Phe His Ser Ser 
        355                 360 


<210>  293
<211>  347
<212>  PRT
<213>  Macaca nemestrina

<400>  293

Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr 
1               5                   10                  15      


Asp Ser Ile Lys Glu Pro Cys Phe Arg Glu Glu Asn Ala His Phe Asn 
            20                  25                  30          


Arg Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile 
        35                  40                  45              


Val Gly Asn Gly Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Leu 
    50                  55                  60                  


Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu 
65                  70                  75                  80  


Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn 
                85                  90                  95      


Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr 
            100                 105                 110         


Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp 
        115                 120                 125             


Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser Gln Lys Pro Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu 
145                 150                 155                 160 


Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Ser Val Ser Glu Ala Asp 
                165                 170                 175     


Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn Asp Leu Trp Val Val 
            180                 185                 190         


Val Phe Gln Phe Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile 
        195                 200                 205             


Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser 
    210                 215                 220                 


Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile 
225                 230                 235                 240 


Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile 
                245                 250                 255     


Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu 
            260                 265                 270         


Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe 
        275                 280                 285             


His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe 
    290                 295                 300                 


Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser 
305                 310                 315                 320 


Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser 
                325                 330                 335     


Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345         


<210>  294
<211>  353
<212>  PRT
<213>  Canis lupus

<400>  294

Met Glu Glu Leu His Ile Tyr Pro Ser Asp Asn Tyr Thr Glu Glu Asp 
1               5                   10                  15      


Leu Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu 
            20                  25                  30          


Glu Asn Ala His Phe Asn Arg Ile Phe Leu Pro Thr Val Tyr Ser Ile 
        35                  40                  45              


Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met 
    50                  55                  60                  


Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His 
65                  70                  75                  80  


Leu Ser Val Ala Asp Leu Leu Phe Val Leu Thr Leu Pro Phe Trp Ala 
                85                  90                  95      


Val Glu Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala 
            100                 105                 110         


Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu 
        115                 120                 125             


Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn 
    130                 135                 140                 


Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly 
145                 150                 155                 160 


Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala 
                165                 170                 175     


Asn Val Arg Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro 
            180                 185                 190         


Asn Asp Ser Trp Leu Val Val Phe Gln Phe Gln His Ile Met Val Gly 
        195                 200                 205             


Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile 
    210                 215                 220                 


Ser Lys Leu Ser His Ser Lys Gly Tyr Gln Lys Arg Lys Ala Leu Lys 
225                 230                 235                 240 


Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr 
                245                 250                 255     


Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys 
            260                 265                 270         


Gln Gly Cys Glu Phe Glu Lys Thr Val His Lys Trp Ile Ser Ile Thr 
        275                 280                 285             


Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala 
    290                 295                 300                 


Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser 
305                 310                 315                 320 


Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly 
                325                 330                 335     


Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser 
            340                 345                 350         


Ser 
    


<210>  295
<211>  353
<212>  PRT
<213>  Sus scrofa

<400>  295

Met Asp Gly Phe Arg Ile Phe Thr Ser Asp Asn Tyr Thr Glu Asp Asp 
1               5                   10                  15      


Leu Gly Ser Gly Asp Tyr Asp Ser Ile Lys Glu Pro Cys Phe Arg Glu 
            20                  25                  30          


Glu Asn Ala His Phe Asn Arg Ile Phe Leu Pro Thr Val Tyr Ser Ile 
        35                  40                  45              


Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met 
    50                  55                  60                  


Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His 
65                  70                  75                  80  


Leu Ser Val Ala Asp Leu Leu Phe Val Leu Thr Leu Pro Phe Trp Ala 
                85                  90                  95      


Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Lys Phe Leu Cys Lys Ala 
            100                 105                 110         


Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu 
        115                 120                 125             


Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn 
    130                 135                 140                 


Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly 
145                 150                 155                 160 


Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala 
                165                 170                 175     


Asn Val Arg Glu Gly Asp Gly Arg Tyr Ile Cys Asp Arg Phe Tyr Pro 
            180                 185                 190         


Asn Asp Leu Trp Leu Val Val Phe Gln Phe Gln His Ile Met Val Gly 
        195                 200                 205             


Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile 
    210                 215                 220                 


Ser Lys Leu Ser His Ser Lys Gly Tyr Gln Lys Arg Lys Ala Leu Lys 
225                 230                 235                 240 


Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr 
                245                 250                 255     


Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Gln 
            260                 265                 270         


Gln Gly Cys Glu Phe Glu Ser Thr Val His Lys Trp Ile Ser Ile Thr 
        275                 280                 285             


Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala 
    290                 295                 300                 


Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser 
305                 310                 315                 320 


Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly 
                325                 330                 335     


Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser 
            340                 345                 350         


Ser 
    


<210>  296
<211>  358
<212>  PRT
<213>  Gallus gallus

<400>  296

Met Asp Gly Leu Asp Leu Ser Ser Gly Ile Leu Ile Glu Phe Ala Asp 
1               5                   10                  15      


Asn Gly Ser Glu Glu Ile Gly Ser Ala Asp Tyr Gly Asp Tyr Gly Glu 
            20                  25                  30          


Pro Cys Phe Gln His Glu Asn Ala Asp Phe Asn Arg Ile Phe Leu Pro 
        35                  40                  45              


Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Ile Gly Asn Gly Leu 
    50                  55                  60                  


Val Ile Ile Val Met Gly Tyr Gln Lys Lys Gln Arg Ser Met Thr Asp 
65                  70                  75                  80  


Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr 
                85                  90                  95      


Leu Pro Phe Trp Ser Val Asp Ala Ala Ile Ser Trp Tyr Phe Gly Asn 
            100                 105                 110         


Val Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser 
        115                 120                 125             


Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile 
    130                 135                 140                 


Val His Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys 
145                 150                 155                 160 


Ile Val Tyr Val Gly Val Trp Leu Pro Ala Val Leu Leu Thr Val Pro 
                165                 170                 175     


Asp Ile Ile Phe Ala Ser Thr Ser Glu Val Glu Gly Arg Tyr Leu Cys 
            180                 185                 190         


Asp Arg Met Tyr Pro His Asp Asn Trp Leu Ile Ser Phe Arg Phe Gln 
        195                 200                 205             


His Ile Leu Val Gly Leu Val Leu Pro Gly Leu Ile Ile Leu Thr Cys 
    210                 215                 220                 


Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys 
225                 230                 235                 240 


Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Thr Phe Phe Ala 
                245                 250                 255     


Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Thr Phe Ile Leu 
            260                 265                 270         


Leu Gly Val Ile Arg His Arg Cys Ser Leu Asp Thr Ile Val His Lys 
        275                 280                 285             


Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn 
    290                 295                 300                 


Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln 
305                 310                 315                 320 


Asn Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser 
                325                 330                 335     


Lys Ser Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser 
            340                 345                 350         


Ser Ser Phe His Ser Ser 
        355             


<210>  297
<211>  339
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  297

Thr Ser Asp Asn Tyr Thr Glu Glu Leu Gly Ser Gly Asp Tyr Asp Ser 
1               5                   10                  15      


Ile Lys Glu Pro Cys Phe Arg Glu Glu Asn Ala His Phe Asn Arg Ile 
            20                  25                  30          


Phe Leu Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly 
        35                  40                  45              


Asn Gly Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Gln Arg Ser 
    50                  55                  60                  


Met Thr Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ile Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr 
                85                  90                  95      


Phe Gly Lys Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn 
            100                 105                 110         


Leu Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val His Ala Thr Asn Ser Gln Lys Pro Arg Lys Leu Leu 
    130                 135                 140                 


Ala Glu Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu 
145                 150                 155                 160 


Thr Ile Pro Asp Phe Ile Phe Ala Asn Val Arg Glu Ala Glu Gly Arg 
                165                 170                 175     


Tyr Ile Cys Asp Arg Phe Tyr Pro Ser Asp Leu Trp Val Val Val Phe 
            180                 185                 190         


Gln Phe Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile 
        195                 200                 205             


Leu Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly 
    210                 215                 220                 


His Gln Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala 
225                 230                 235                 240 


Phe Phe Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser 
                245                 250                 255     


Phe Ile Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr 
            260                 265                 270         


Val His Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys 
        275                 280                 285             


Cys Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr 
    290                 295                 300                 


Ser Ala Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys 
305                 310                 315                 320 


Ile Leu Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu 
                325                 330                 335     


Ser Glu Ser 
            


<210>  298
<211>  359
<212>  PRT
<213>  Mus musculus

<400>  298

Met Glu Pro Ile Ser Val Ser Ile Tyr Thr Ser Asp Asn Tyr Ser Glu 
1               5                   10                  15      


Glu Val Gly Ser Gly Asp Tyr Asp Ser Asn Lys Glu Pro Cys Phe Arg 
            20                  25                  30          


Asp Glu Asn Val His Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Phe 
        35                  40                  45              


Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val 
    50                  55                  60                  


Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu 
65                  70                  75                  80  


His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp 
                85                  90                  95      


Ala Val Asp Ala Met Ala Asp Trp Tyr Phe Gly Lys Phe Leu Cys Lys 
            100                 105                 110         


Ala Val His Ile Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile 
        115                 120                 125             


Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr 
    130                 135                 140                 


Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Ala Val Tyr Val 
145                 150                 155                 160 


Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe 
                165                 170                 175     


Ala Asp Val Ser Gln Gly Asp Ile Ser Gln Gly Asp Asp Arg Tyr Ile 
            180                 185                 190         


Cys Asp Arg Leu Tyr Pro Asp Ser Leu Trp Met Val Val Phe Gln Phe 
        195                 200                 205             


Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser 
    210                 215                 220                 


Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln 
225                 230                 235                 240 


Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe 
                245                 250                 255     


Ala Cys Trp Leu Pro Tyr Tyr Val Gly Ile Ser Ile Asp Ser Phe Ile 
            260                 265                 270         


Leu Leu Gly Val Ile Lys Gln Gly Cys Asp Phe Glu Ser Ile Val His 
        275                 280                 285             


Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu 
    290                 295                 300                 


Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Ser Ser Ala 
305                 310                 315                 320 


Gln His Ala Leu Asn Ser Met Ser Arg Gly Ser Ser Leu Lys Ile Leu 
                325                 330                 335     


Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu 
            340                 345                 350         


Ser Ser Ser Phe His Ser Ser 
        355                 


<210>  299
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210>  300
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  301
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  302
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser Thr 
1               5                   10                  15      


Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser Tyr 
            20                  25                  30          


Ser Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser Arg Cys 
        35                  40                  45              


Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu Ser His Leu 
    50                  55                  60                  


Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu Ala Leu Gly 
65                  70                  75                  80  


Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val Ala Val Glu Thr 
                85                  90                  95      


Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly His Leu Lys Thr Leu 
            100                 105                 110         


Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln Ser Phe Lys Leu Pro 
        115                 120                 125             


Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu His Leu Asp Leu Ser Ser 
    130                 135                 140                 


Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His Gln 
145                 150                 155                 160 


Met Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro Met Asn 
                165                 170                 175     


Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His Lys Leu Thr 
            180                 185                 190         


Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr Cys Ile Gln 
        195                 200                 205             


Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu Gly Glu Phe Arg 
    210                 215                 220                 


Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser Ala Leu Glu Gly Leu 
225                 230                 235                 240 


Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu Ala Tyr Leu Asp Tyr Tyr 
                245                 250                 255     


Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys Leu Thr Asn Val Ser Ser 
            260                 265                 270         


Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser Tyr 
        275                 280                 285             


Asn Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe Gly Gln 
    290                 295                 300                 


Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr Phe Thr Ser 
305                 310                 315                 320 


Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp Leu Pro Ser Leu Glu 
                325                 330                 335     


Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe Lys Gly Cys Cys Ser 
            340                 345                 350         


Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr Leu Asp Leu Ser Phe 
        355                 360                 365             


Asn Gly Val Ile Thr Met Ser Ser Asn Phe Leu Gly Leu Glu Gln Leu 
    370                 375                 380                 


Glu His Leu Asp Phe Gln His Ser Asn Leu Lys Gln Met Ser Glu Phe 
385                 390                 395                 400 


Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp Ile Ser His 
                405                 410                 415     


Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly Leu Ser Ser 
            420                 425                 430         


Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe Gln Glu Asn Phe Leu 
        435                 440                 445             


Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu Thr Phe Leu Asp Leu Ser 
    450                 455                 460                 


Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala Phe Asn Ser Leu Ser 
465                 470                 475                 480 


Ser Leu Gln Val Leu Asn Met Ser His Asn Asn Phe Phe Ser Leu Asp 
                485                 490                 495     


Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln Val Leu Asp Tyr Ser 
            500                 505                 510         


Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu Leu Gln His Phe Pro 
        515                 520                 525             


Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln Asn Asp Phe Ala Cys Thr 
    530                 535                 540                 


Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln Arg Gln Leu 
545                 550                 555                 560 


Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser Asp Lys Gln 
                565                 570                 575     


Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln Met Asn Lys Thr 
            580                 585                 590         


Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val Ala 
        595                 600                 605             


Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly Cys 
    610                 615                 620                 


Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr 
625                 630                 635                 640 


Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu 
                645                 650                 655     


Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe 
            660                 665                 670         


Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His 
        675                 680                 685             


Lys Ser Arg Lys Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser 
    690                 695                 700                 


Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu 
705                 710                 715                 720 


Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys 
                725                 730                 735     


Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn 
            740                 745                 750         


Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp 
        755                 760                 765             


Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu 
    770                 775                 780                 


Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 
785                 790                 795                 


<210>  303
<211>  1048
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Gln Asp 
                165                 170                 175     


Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser Ile Asp 
            180                 185                 190         


Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser Phe Tyr 
        195                 200                 205             


Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys 
    210                 215                 220                 


Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr 
225                 230                 235                 240 


Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val 
                245                 250                 255     


Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly 
            260                 265                 270         


Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly 
        275                 280                 285             


Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala 
    290                 295                 300                 


Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr 
305                 310                 315                 320 


Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp 
                325                 330                 335     


Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala 
            340                 345                 350         


Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala 
        355                 360                 365             


Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly 
    370                 375                 380                 


Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys 
385                 390                 395                 400 


Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val 
                405                 410                 415     


Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro 
            420                 425                 430         


Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly 
        435                 440                 445             


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu 
    450                 455                 460                 


Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr 
465                 470                 475                 480 


Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr 
                485                 490                 495     


Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp 
            500                 505                 510         


Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu 
        515                 520                 525             


Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu 
    530                 535                 540                 


Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly 
545                 550                 555                 560 


Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser 
                565                 570                 575     


Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg 
            580                 585                 590         


Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu 
        595                 600                 605             


Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu 
    610                 615                 620                 


Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val 
625                 630                 635                 640 


Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr 
                645                 650                 655     


Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu 
            660                 665                 670         


Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg 
        675                 680                 685             


Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn 
    690                 695                 700                 


Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly 
705                 710                 715                 720 


Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu 
                725                 730                 735     


Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu 
            740                 745                 750         


Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val 
        755                 760                 765             


Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His Ile Phe 
    770                 775                 780                 


Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu 
785                 790                 795                 800 


Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly 
                805                 810                 815     


Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys 
            820                 825                 830         


Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly 
        835                 840                 845             


Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys 
    850                 855                 860                 


Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln 
865                 870                 875                 880 


Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu 
                885                 890                 895     


Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile 
            900                 905                 910         


Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr 
        915                 920                 925             


Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln 
    930                 935                 940                 


Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu 
945                 950                 955                 960 


Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu 
                965                 970                 975     


Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val 
            980                 985                 990         


Pro Val Trp Val Ile Ile Leu Ala  Val Leu Ala Gly Leu  Leu Leu Leu 
        995                 1000                 1005             


Ala Val  Leu Val Phe Val Met  Tyr Arg Met Gly Phe  Phe Lys Arg 
    1010                 1015                 1020             


Val Arg  Pro Pro Gln Glu Glu  Gln Glu Arg Glu Gln  Leu Gln Pro 
    1025                 1030                 1035             


His Glu  Asn Gly Glu Gly Asn  Ser Glu Thr 
    1040                 1045             


<210>  304
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  305
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  306
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Glu Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  307
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  308
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
465                 470                 475                 480 


Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                485                 490                 495     


Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu 
            500                 505                 


<210>  309
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  310
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 
            100                 105                 110         


Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
            180                 185                 190         


Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
        195                 200                 205             


Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 220 


<210>  311
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Ala Ser Thr Gly Leu Glu Leu Leu Gly Met Thr Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Gly Thr Leu Val Ser Cys Ala Leu Pro Leu Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Leu Ala Leu Leu Gly Leu Leu 
                85                  90                  95      


Val Ala Ile Thr Gly Ala Gln Cys Thr Thr Cys Val Glu Asp Glu Gly 
            100                 105                 110         


Ala Lys Ala Arg Ile Val Leu Thr Ala Gly Val Ile Leu Leu Leu Ala 
        115                 120                 125             


Gly Ile Leu Val Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Leu Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ala Ala Leu Leu Met Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg 
            180                 185                 190         


Pro Arg Gly Pro Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala 
        195                 200                 205             


Ser Gly Leu Asp Lys Arg Asp Tyr Val 
    210                 215         


