                              Sequence Listing

<110> Genentech, Inc. et al.

<120> TREATMENT METHOD

<130> P4278R1 WO 


<150> US 61/152,570
<151> 2009-02-13

<150> US 61/106,495
<151> 2008-10-17

<160> 30

<210> 1
<211> 17
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 1
 Lys Ser Ser Gln Ser Leu Leu Tyr Thr Ser Ser Gln Lys Asn Tyr
   1               5                  10                  15

 Leu Ala
        

<210> 2
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 2
 Trp Ala Ser Thr Arg Glu Ser
                   5        

<210> 3
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 3
 Gln Gln Tyr Tyr Ala Tyr Pro Trp Thr
                   5                

<210> 4
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 4
 Gly Tyr Thr Phe Thr Ser Tyr Trp Leu His
                   5                  10

<210> 5
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 5
 Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe Asn Pro Asn
   1               5                  10                  15

 Phe Lys Asp
            

<210> 6
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> X is any amino acid except R

<400> 6
 Xaa Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr
                   5                  10    

<210> 7
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 7
 Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr
                   5                  10    

<210> 8
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 8
 Ser Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr
                   5                  10    

<210> 9
<211> 12
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 9
 Ala Thr Tyr Arg Ser Tyr Val Thr Pro Leu Asp Tyr
                   5                  10        

<210> 10
<211> 119
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 10
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe
                  50                  55                  60

 Asn Pro Asn Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Thr Tyr Arg Ser Tyr Val Thr Pro
                  95                 100                 105

 Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                

<210> 11
<211> 114
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 11
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Tyr Thr Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys
                  35                  40                  45

 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
                  50                  55                  60

 Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
                  65                  70                  75

 Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
                  80                  85                  90

 Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly
                  95                 100                 105

 Gln Gly Thr Lys Val Glu Ile Lys Arg
                 110                

<210> 12
<211> 222
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 12
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 215                 220        

<210> 13
<211> 222
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 13
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 215                 220        

<210> 14
<211> 449
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 14
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe
                  50                  55                  60

 Asn Pro Asn Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Thr Tyr Arg Ser Tyr Val Thr Pro
                  95                 100                 105

 Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
                 110                 115                 120

 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
                 125                 130                 135

 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
                 140                 145                 150

 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
                 155                 160                 165

 Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                 170                 175                 180

 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
                 185                 190                 195

 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
                 200                 205                 210

 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
                 215                 220                 225

 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
                 230                 235                 240

 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                 245                 250                 255

 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                 260                 265                 270

 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                 275                 280                 285

 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
                 290                 295                 300

 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
                 305                 310                 315

 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                 320                 325                 330

 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                 335                 340                 345

 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
                 350                 355                 360

 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr
                 365                 370                 375

 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                 380                 385                 390

 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
                 395                 400                 405

 Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                 410                 415                 420

 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
                 425                 430                 435

 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 440                 445                

<210> 15
<211> 220
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 15
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Tyr Thr Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys
                  35                  40                  45

 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
                  50                  55                  60

 Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
                  65                  70                  75

 Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
                  80                  85                  90

 Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly
                  95                 100                 105

 Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser
                 110                 115                 120

 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
                 125                 130                 135

 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
                 140                 145                 150

 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
                 155                 160                 165

 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                 170                 175                 180

 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His
                 185                 190                 195

 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                 200                 205                 210

 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
                 215                 220

<210> 16
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 16
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 17
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 17
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 18
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 18
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 19
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 19
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 20
<211> 106
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 20
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 21
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 21
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 22
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 22
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 23
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 23
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 24
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 24
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 25
<211> 5
<212> PRT
<213> Homo sapiens

<400> 25
 Leu Asp Ala Gln Thr
                   5

<210> 26
<211> 9
<212> PRT
<213> Homo sapiens

<400> 26
 Leu Thr Glu Lys Arg Lys Lys Arg Ser
                   5                

<210> 27
<211> 8
<212> PRT
<213> Homo sapiens

<400> 27
 Lys Pro Asp Ser Ala Glu Pro Met
                   5            

<210> 28
<211> 8
<212> PRT
<213> Homo sapiens

<400> 28
 Asn Val Arg Cys Leu Gln His Phe
                   5            

<210> 29
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 29
 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
                   5                  10    

<210> 30
<211> 108
<212> PRT
<213> Homo sapiens

<400> 30
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

