                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Muzykantov, Vladimir R.
       Ding, Bi-Sen
       Cines, Douglas B.
       Gottstein, Claudia
       Albelda, Steven M.
 
<120>  Compositions Containing Thrombomodulin Domains and Uses Thereof

<130>  UPN-V4977PCT

<150>  US 61/105,956
<151>  2008-10-16

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  8532
<212>  DNA
<213>  Homo sapiens

<400>  1
atctgcacct cctcatatag ggttgatcca agtttcacag acatcactga gttcttagtg       60

gactcagcta ttggggctgt tctcacactt tttttttctt tgcaagaatc agcaatgggt      120

gcaagtggac ctgtgtagga cgtccagtga aacattgtgt tggtgaatca gctagaatcc      180

atccaagaac tcagccagcc tggtgtgggg tgagatctga tccttgaatg tccctcagtg      240

gcttttaggg ctggcaggtt cagaagggcc ctctcatcac ccccccaggg cctcattcct      300

tgtttaacac tttgctatca cagtcttgaa tccttgtaat tgaacaatgg accccacatt      360

ttcactttgc actggtttct gattctgtaa ccgatcctgt ccccctctct tgtctcattc      420

actctgggaa ttgtccccac attctgagac ctttcagcag tgccccaacg aggttcctgc      480

ccttatctga agctccaccc tcacccccat ggcggcaccg caggcagccc tgcttttgcg      540

tcccgcgtag gcaggctgtg caccggagtc acgaccccct gattcagcct aggcagccac      600

agcttgactg ctcccgccgg acaagcccta ctgtgctatc tgccgctctt cccttcctct      660

tcccaggggg tccgcgtcag gggaggcgca gctgtgtgca ttccgggagc ttcagacccc      720

cgtgtccagc agctccttcg tttcctgggt gctggggcgg ccttcccagc gaagagctca      780

actcagcggg acgtttggag gctctctgcc ccaaggcgct ggggagtgtg cggcgggaca      840

gtcgtgcttg cctttttcac tttcagagtg tccacgcccc acccgtttgg tcactgcagg      900

tcagtccagt ccagcccggc ccaccccacc ggtgcgtgtc tgtcgcacgt ggcagacgcc      960

atactctctg ttcttgttta aagcccagga tctactgggc cctggaggca agaggtgaac     1020

gcagcggaat ccacgctgag ctgcccggga acggagcttc caaccccaga aggaggactc     1080

tgtgctccta caccttaacc ctttttagcc cgaaacttct ccaacttcct tggctttgtt     1140

tagagctcga cagcgccgcc ccctggcgct cgttgtgagg acagtagagg agagaggcaa     1200

gggtgttttt aaacagtttg cctctcacca ttatgggggc gacccgaggg ggagacccac     1260

tcttccgcat tcccggtaag tgaaccaccg gaagaggtcg aaagtgacgg attcccatgt     1320

cctcctccag cccccccccc accctgccca tccacaggac ggtggctctt cagtgccctt     1380

tgccgagcaa gtggcgtttc tatgcacgtg ggtatcaatt cggactctgg acgaaatgga     1440

aacctcctta gccgacccgg gtgggatcag ctgggatcct gcgcgctccc ctggggggtt     1500

gccagccact ctgttggggt gcaagaagca ccatccttcg gaagctgggc cgaaactggc     1560

caggctgact cgctcccacg cgcccgcccc tacccggcgc cgcagcaatt cacctgccac     1620

cgcctctgag ccgggtccgg acttcggcgc cctgacagtg tccccgcgac ttccccaccc     1680

gatgagatgg ggtctggcgt tggccagtgc gtgtccaggg actcgcgggt ccctggccag     1740

ccatggggca gagggcgctg gtgttaggcc agtcttcccc accctgcccc gtcaccccag     1800

ccacacccac tgtcctgtga ggccaagcgc gctccgctgg tttcctgagc caggcacctt     1860

ggccgcggac aggatccagc tgtctctcct tgcgatcctg tcttcgggga agtccacgtc     1920

ctaggcaggt cctcccaaag tgcccttggt gccgatcacc cctcccagcg tcttgcaggt     1980

cctgtgcacc acctccccca ctccccattc aaagccctct tctctgaagt ctccggttcc     2040

cagagctctt gcaatccagg ctttccttgg aagtggctgt aacatgtatg aaaagaaaga     2100

aaggaggacc aagagatgaa agagggctgc acgcgtgggg gcccgagtgg tgggcgggga     2160

cagtcgtctt gttacagggg tgctggcctt ccctggcgcc tgcccctgtc ggccccgccc     2220

gagaacctcc ctgcgccagg gcagggttta ctcatcccgg cgaggtgatc ccatgcgcga     2280

gggcgggcgc aagggcggcc agagaaccca gcaatccgag tatgcggcat cagcccttcc     2340

caccaggcac ttccttcctt ttcccgaacg tccagggagg gagggccggg cacttataaa     2400

ctcgagccct ggccgatccg catgtcagag gctgcctcgc aggggctgcg cgcagcggca     2460

agaagtgtct gggctgggac ggacaggaga ggctgtcgcc atcggcgtcc tgtgcccctc     2520

tgctccggca cggccctgtc gcagtgcccg cgctttcccc ggcgcctgca cgcggcgcgc     2580

ctgggtaaca tgcttggggt cctggtcctt ggcgcgctgg ccctggccgg cctggggttc     2640

cccgcacccg cagagccgca gccgggtggc agccagtgcg tcgagcacga ctgcttcgcg     2700

ctctacccgg gccccgcgac cttcctcaat gccagtcaga tctgcgacgg actgcggggc     2760

cacctaatga cagtgcgctc ctcggtggct gccgatgtca tttccttgct actgaacggc     2820

gacggcggcg ttggccgccg gcgcctctgg atcggcctgc agctgccacc cggctgcggc     2880

gaccccaagc gcctcgggcc cctgcgcggc ttccagtggg ttacgggaga caacaacacc     2940

agctatagca ggtgggcacg gctcgacctc aatggggctc ccctctgcgg cccgttgtgc     3000

gtcgctgtct ccgctgctga ggccactgtg cccagcgagc cgatctggga ggagcagcag     3060

tgcgaagtga aggccgatgg cttcctctgc gagttccact tcccagccac ctgcaggcca     3120

ctggctgtgg agcccggcgc cgcggctgcc gccgtctcga tcacctacgg caccccgttc     3180

gcggcccgcg gagcggactt ccaggcgctg ccggtgggca gctccgccgc ggtggctccc     3240

ctcggcttac agctaatgtg caccgcgccg cccggagcgg tccaggggca ctgggccagg     3300

gaggcgccgg gcgcttggga ctgcagcgtg gagaacggcg gctgcgagca cgcgtgcaat     3360

gcgatccctg gggctccccg ctgccagtgc ccagccggcg ccgccctgca ggcagacggg     3420

cgctcctgca ccgcatccgc gacgcagtcc tgcaacgacc tctgcgagca cttctgcgtt     3480

cccaaccccg accagccggg ctcctactcg tgcatgtgcg agaccggcta ccggctggcg     3540

gccgaccaac accggtgcga ggacgtggat gactgcatac tggagcccag tccgtgtccg     3600

cagcgctgtg tcaacacaca gggtggcttc gagtgccact gctaccctaa ctacgacctg     3660

gtggacggcg agtgtgtgga gcccgtggac ccgtgcttca gagccaactg cgagtaccag     3720

tgccagcccc tgaaccaaac tagctacctc tgcgtctgcg ccgagggctt cgcgcccatt     3780

ccccacgagc cgcacaggtg ccagatgttt tgcaaccaga ctgcctgtcc agccgactgc     3840

gaccccaaca cccaggctag ctgtgagtgc cctgaaggct acatcctgga cgacggtttc     3900

atctgcacgg acatcgacga gtgcgaaaac ggcggcttct gctccggggt gtgccacaac     3960

ctccccggta ccttcgagtg catctgcggg cccgactcgg cccttgcccg ccacattggc     4020

accgactgtg actccggcaa ggtggacggt ggcgacagcg gctctggcga gcccccgccc     4080

agcccgacgc ccggctccac cttgactcct ccggccgtgg ggctcgtgca ttcgggcttg     4140

ctcataggca tctccatcgc gagcctgtgc ctggtggtgg cgcttttggc gctcctctgc     4200

cacctgcgca agaagcaggg cgccgccagg gccaagatgg agtacaagtg cgcggcccct     4260

tccaaggagg tagtgctgca gcacgtgcgg accgagcgga cgccgcagag actctgagcg     4320

gcctccgtcc aggagcctgg ctccgtccag gagcctgtgc ctcctcaccc ccagctttgc     4380

taccaaagca ccttagctgg cattacagct ggagaagacc ctccccgcac cccccaagct     4440

gttttcttct attccatggc taactggcga gggggtgatt agagggagga gaatgagcct     4500

cggcctcttc cgtgacgtca ctggaccact gggcaatgat ggcaattttg taacgaagac     4560

acagactgcg atttgtccca ggtcctcact accgggcgca ggagggtgag cgttattggt     4620

cggcagcctt ctgggcagac cttgacctcg tgggctaggg atgactaaaa tatttatttt     4680

ttttaagtat ttaggttttt gtttgtttcc tttgttctta cctgtatgtc tccagtatcc     4740

actttgcaca gctctccggt ctctctctct ctacaaactc ccacttgtca tgtgacaggt     4800

aaactatctt ggtgaatttt tttttcctag ccctctcaca tttatgaagc aagccccact     4860

tattccccat tcttcctagt tttctcctcc caggaactgg gccaactcac ctgagtcacc     4920

ctacctgtgc ctgaccctac ttcttttgct cttagctgtc tgctcagaca gaacccctac     4980

atgaaacaga aacaaaaaca ctaaaaataa aaatggccat ttgctttttc accagatttg     5040

ctaatttatc ctgaaatttc agattcccag agcaaaataa ttttaaacaa aggttgagat     5100

gtaaaaggta ttaaattgat gttgctggac tgtcatagaa attacaccca aagaggtatt     5160

tatctttact tttaaacagt gagcctgaat tttgttgctg ttttgatttg tactgaaaaa     5220

tggtaattgt tgctaatctt cttatgcaat ttcctttttt gttattatta cttatttttg     5280

acagtgttga aaatgttcag aaggttgctc tagattgaga gaagagacaa acacctccca     5340

ggagacagtt caagaaagct tcaaactgca tgattcatgc caattagcaa ttgactgtca     5400

ctgttccttg tcactggtag accaaaataa aaccagctct actggtcttg tggaattggg     5460

agcttgggaa tggatcctgg aggatgccca attagggcct agccttaatc aggtcctcag     5520

agaatttcta ccatttcaga gaggcctttt ggaatgtggc ccctgaacaa gaattggaag     5580

ctgccctgcc catgggagct ggttagaaat gcagaatcct aggctccacc ccatccagtt     5640

catgagaatc tatatttaac aagatctgca gggggtgtgt ctgctcagta atttgaggac     5700

aaccattcca gactgcttcc aattttctgg aatacatgaa atatagatca gttataagta     5760

gcaggccaag tcaggccctt attttcaaga aactgaggaa ttttctttgt gtagctttgc     5820

tctttggtag aaaaggctag gtacacagct ctagacactg ccacacaggg tctgcaaggt     5880

ctttggttca gctaagctag gaatgaaatc ctgcttcagt gtatggaaat aaatgtatca     5940

tagaaatgta acttttgtaa gacaaaggtt ttcctcttct attttgtaaa ctcaaaatat     6000

ttgtacatag ttatttattt attggagata atctagaaca caggcaaaat ccttgcttat     6060

gacatcactt gtacaaaata aacaaataac aatgtgctct cgggttgtgt gtctgttcac     6120

ttttcctccc tcagtgccct cattttatgt cattaaatgg ggctcacaaa ccatgcaaat     6180

gctatgagat gcatggaggg ctgccctgta ccccagcact tgtgttgtct ggtgatggca     6240

ccatctctga ttttcaaagc tttttccaga ggctattatt ttcactgtag aatgatttca     6300

tgctatctct gtgtgcacaa atatttattt tctttctgta accataacaa cttcatatat     6360

gaggacttgt gtctctgtgc ttttaaatgc ataaatgcat tataggatca tttgttggaa     6420

tgaattaaat aaacccttcc tggggcatct ggcgaatccc agctgtgtgt ccggtgtatg     6480

gtttggcatt atctcctctg cgagatatcc aaattcactg tagtcatgaa gggtctcagt     6540

ttgtggctct cattcaaata ttcatttcta aacgtctcat ccagtatgaa atcattctca     6600

tctcttttgg agattaacaa catcatcttt tcaatgcaca cgtttcttgg gctcactttt     6660

ctaaggtggt agggctggct gaatgcaata tgcagggctc ggaaagattt tttaaagaag     6720

aaattaaaag caagtagagt ccaggcaaat attcagatgc tttatatgtc tggataatgc     6780

tgaactcatg agttttagtt tgactgatta ttgtgaagac cgggttggag attttgacat     6840

ccatcgcaga agaagtaatg gctttagtgt gtgtgtgtgt gtgtgctggg gaagctccat     6900

gcacagtgcc ctatggagat aacaagctga gccatgctcc ccctaagtag cagactaagt     6960

ctttgtgaag gaagagctac acaaatgggg gcaggacagg tgcagataaa tggggctggg     7020

agaccagagg agacagtgac accttatagt tcgccccctg ttacccagcc ttctgtttgt     7080

caaaagagtc tgctcccagt cactgtcaaa ctgacttgta gggcctcatt gcgttaggat     7140

ttcttcttat tccagaagag gggcattttc ttaaggaaca ctggaagacc aaaacacact     7200

ttcaaaacct agaggcaaaa acccttcatg cagcacttgg gccccaggac attagttgtg     7260

cggggccctg agcttccctg tcctcctcac ttcctgctgc ctgggggatc agcagttctg     7320

tttataggtc tcatctgaac ttgagattct caaaacgcta aatagccata gtgcctctca     7380

gggaaagata ccaggaccac ataaacaaat cagttagctt taaaaactat ccctgagcat     7440

ttaaaatcag gatagacctt gtgaaaccag agccatgggt caacctgtgt gatctctgct     7500

ttctgttcac atcattggac atccaggtct gagggagact cccagggacc agttgctggt     7560

gaaatttcat agcacaaaag tccggggcaa gaaagccaag gtggtatttc tggataagcc     7620

agcattcaag tttgtttgtt tgtttgtttg tttgtttttc ctagcctgct gttttaaagt     7680

aaacagaatg cattttttta agtcaaatga ctttgttatt ttttttttcc agttctcacc     7740

tatttcttag attagttcag caattattta ctgagcattt actctgtgcc tttcatagtg     7800

ataggcacaa tgacaagtcc ctaccatata agttagactc tggcagggga gaaagatgca     7860

aaacaactga tcacccccaa attgtactta acttagaaac agtgataagt gcaggggaag     7920

aaaagcacag cacactctga aaaggcgcac gaggaaggca ggatttagag tggaggacta     7980

gagggagctt cctggacaag ctgacactta acaccagacc tgaaggggaa ggaggggttt     8040

gtcaaatgca aactggaggg gaagcagtcc aggtgggaag gatcacacct gcaaaggccc     8100

tgtactggga agagccctgg tggagcggac tgggcatagt gaacaaggtg aggtgggctg     8160

caaggcagct gaagaggtgg aaagagagat acaagcagtg ggagatgact gtaggggctg     8220

taggtcaaag acactgaaaa aaagactgaa agagtgacat tgaaaaatgt tctgggtgca     8280

agtgggggca ctcaaggagt tttgatgaga gtgcactggg attcaattta tgtactgcat     8340

tgtttgggaa gataacaact acttctagat gtatttacat gtccctcttg ggcaggaacc     8400

tgcacaattt ccgctgtaag caccccgcag ggctgatatg tggtgtgaac agcatacaca     8460

cctgggtgtg accccagcct gaaacctgct ggtcacatgg ccacgggcac cacatgaccc     8520

ttcaaaggct gt                                                         8532


<210>  2
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
        515                 520                 525             


Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
    530                 535                 540                 


Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
545                 550                 555                 560 


Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                565                 570                 575 


<210>  3
<211>  577
<212>  PRT
<213>  Mus musculus

<400>  3

Met Leu Gly Ile Phe Phe Leu Gly Val Leu Ala Pro Ala Ser Leu Gly 
1               5                   10                  15      


Leu Ser Ala Leu Ala Lys Leu Gln Pro Thr Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Glu Cys Phe Ala Leu Phe Gln Gly Pro Ala Thr Phe Leu Asp Ala 
        35                  40                  45              


Ser Gln Ala Cys Gln Arg Leu Gln Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Ser Gln Ser Ser Met 
65                  70                  75                  80  


Asp Leu Gly Pro Trp Ile Gly Leu Gln Leu Pro Gln Gly Cys Asp Asp 
                85                  90                  95      


Pro Val His Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
            100                 105                 110         


Asn His Thr Ser Tyr Ser Arg Trp Ala Arg Pro Asn Asp Gln Thr Ala 
        115                 120                 125             


Pro Leu Cys Gly Pro Leu Cys Val Thr Val Ser Thr Ala Thr Glu Ala 
    130                 135                 140                 


Ala Pro Gly Glu Pro Ala Trp Glu Glu Lys Pro Cys Glu Thr Glu Thr 
145                 150                 155                 160 


Gln Gly Phe Leu Cys Glu Phe Tyr Phe Thr Ala Ser Cys Arg Pro Leu 
                165                 170                 175     


Thr Val Asn Thr Arg Asp Pro Glu Ala Ala His Ile Ser Ser Thr Tyr 
            180                 185                 190         


Asn Thr Pro Phe Gly Val Ser Gly Ala Asp Phe Gln Thr Leu Pro Val 
        195                 200                 205             


Gly Ser Ser Ala Ala Val Glu Pro Leu Gly Leu Glu Leu Val Cys Arg 
    210                 215                 220                 


Ala Pro Pro Gly Thr Ser Glu Gly His Trp Ala Trp Glu Ala Thr Gly 
225                 230                 235                 240 


Ala Trp Asn Cys Ser Val Glu Asn Gly Gly Cys Glu Tyr Leu Cys Asn 
                245                 250                 255     


Arg Ser Thr Asn Glu Pro Arg Cys Leu Cys Pro Arg Asp Met Asp Leu 
            260                 265                 270         


Gln Ala Asp Gly Arg Ser Cys Ala Arg Pro Val Val Gln Ser Cys Asn 
        275                 280                 285             


Glu Leu Cys Glu His Phe Cys Val Ser Asn Ala Glu Val Pro Gly Ser 
    290                 295                 300                 


Tyr Ser Cys Met Cys Glu Thr Gly Tyr Gln Leu Ala Ala Asp Gly His 
305                 310                 315                 320 


Arg Cys Glu Asp Val Asp Asp Cys Lys Gln Gly Pro Asn Pro Cys Pro 
                325                 330                 335     


Gln Leu Cys Val Asn Thr Lys Gly Gly Phe Glu Cys Phe Cys Tyr Asp 
            340                 345                 350         


Gly Tyr Glu Leu Val Asp Gly Glu Cys Val Glu Leu Leu Asp Pro Cys 
        355                 360                 365             


Phe Gly Ser Asn Cys Glu Phe Gln Cys Gln Pro Val Ser Pro Thr Asp 
    370                 375                 380                 


Tyr Arg Cys Ile Cys Ala Pro Gly Phe Ala Pro Lys Pro Asp Glu Pro 
385                 390                 395                 400 


His Lys Cys Glu Met Phe Cys Asn Glu Thr Ser Cys Pro Ala Asp Cys 
                405                 410                 415     


Asp Pro Asn Ser Pro Thr Val Cys Glu Cys Pro Glu Gly Phe Ile Leu 
            420                 425                 430         


Asp Glu Gly Ser Val Cys Thr Asp Ile Asp Glu Cys Ser Gln Gly Glu 
        435                 440                 445             


Cys Phe Thr Ser Glu Cys Arg Asn Phe Pro Gly Ser Tyr Glu Cys Ile 
    450                 455                 460                 


Cys Gly Pro Asp Thr Ala Leu Ala Gly Gln Ile Ser Lys Asp Cys Asp 
465                 470                 475                 480 


Pro Ile Pro Val Arg Glu Asp Thr Lys Glu Glu Glu Gly Ser Gly Glu 
                485                 490                 495     


Pro Pro Val Ser Pro Thr Pro Gly Ser Pro Thr Gly Pro Pro Ser Ala 
            500                 505                 510         


Arg Pro Val His Ser Gly Val Leu Ile Gly Ile Ser Ile Ala Ser Leu 
        515                 520                 525             


Ser Leu Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys 
    530                 535                 540                 


Gln Gly Ala Ala Arg Ala Glu Leu Glu Tyr Lys Cys Ala Ser Ser Ala 
545                 550                 555                 560 


Lys Glu Val Val Leu Gln His Val Arg Thr Asp Arg Thr Leu Gln Lys 
                565                 570                 575     


Phe 
    


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker based on Homo sapiens

<400>  4

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ala Ala Ala 
1               5                   10              


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker based on Homo sapiens

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site based on Homo sapiens

<400>  6

Met Tyr Arg Gly Asn 
1               5   


<210>  7
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer based on Mus musculus

<400>  7
ataagaatgc ggccgcactc tccgcactag cc                                     32


<210>  8
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer based on Mus musculus

<400>  8
gtcatggtct ttgtagtcag agtgcactgg ccttg                                  35


<210>  9
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer based on Mus musculus

<400>  9
gctcgagtca tcacttgtca tcgtcatcct tgtaatcgat atcatgatct ttataatcac       60

cgtcatggtc tttgtagtc                                                    79


