                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc.
 
<120>  Recombinant FcRN and Variants Thereof For Purification of Fc- 
       Containing Fusion Proteins

<130>  2159.177PC01

<160>  38    

<170>  PatentIn version 3.3

<210>  1
<211>  1098
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggggtcc cgcggcctca gccctgggcg ctggggctcc tgctctttct ccttcctggg     60

agcctgggcg cagaaagcca cctctccctc ctgtaccacc ttaccgcggt gtcctcgcct    120

gccccgggga ctcctgcctt ctgggtgtcc ggctggctgg gcccgcagca gtacctgagc    180

tacaatagcc tgcggggcga ggcggagccc tgtggagctt gggtctggga aaaccaggtg    240

tcctggtatt gggagaaaga gaccacagat ctgaggatca aggagaagct ctttctggaa    300

gctttcaaag ctttgggggg aaaaggtccc tacactctgc agggcctgct gggctgtgaa    360

ctgggccctg acaacacctc ggtgcccacc gccaagttcg ccctgaacgg cgaggagttc    420

atgaatttcg acctcaagca gggcacctgg ggtggggact ggcccgaggc cctggctatc    480

agtcagcggt ggcagcagca ggacaaggcg gccaacaagg agctcacctt cctgctattc    540

tcctgcccgc accgcctgcg ggagcacctg gagaggggcc gcggaaacct ggagtggaag    600

gagcccccct ccatgcgcct gaaggcccga cccagcagcc ctggcttttc cgtgcttacc    660

tgcagcgcct tctccttcta ccctccggag ctgcaacttc ggttcctgcg gaatgggctg    720

gccgctggca ccggccaggg tgacttcggc cccaacagtg acggatcctt ccacgcctcg    780

tcgtcactaa cagtcaaaag tggcgatgag caccactact gctgcattgt gcagcacgcg    840

gggctggcgc agcccctcag ggtggagctg gaatctccag ccaagtcctc cgtgctcgtg    900

gtgggaatcg tcatcggtgt cttgctactc acggcagcgg ctgtaggagg agctctgttg    960

tggagaagga tgaggagtgg gctgccagcc ccttggatct cccttcgtgg agacgacacc   1020

ggggtcctcc tgcccacccc aggggaggcc caggatgctg atttgaagga tgtaaatgtg   1080

attccagcca ccgcctga                                                 1098


<210>  2
<211>  1098
<212>  DNA
<213>  Mus musculus

<400>  2
atggggatgc cactgccctg ggccctcagc ctcttgttgg tcctcctgcc tcagacctgg     60

ggctcagaga cccgcccccc actgatgtat catctcacgg ctgtgtcaaa cccatctacg    120

gggcttccct ctttctgggc tacaggctgg ttgggtcctc agcagtatct gacctacaac    180

agcctgcggc aggaagctga cccctgtggg gcctgggtgt gggaaaatca ggtgtcttgg    240

tattgggaga aggagaccac agacctcaaa agcaaagaac agctcttctt ggaggccctc    300

aagaccctgg agaagatatt aaatgggacc tacacactgc agggcctgct gggctgtgaa    360

ctggcctcgg ataattcctc agtgcccacg gctgtgtttg ccctcaatgg tgaggagttt    420

atgaaattca acccaagaat cggcaattgg actggggagt ggcctgagac ggaaatcgtt    480

gctaatctgt ggatgaagca gcctgatgcg gccaggaagg agagcgagtt cctgctaaac    540

tcttgtccgg agcgactgct aggccacctg gagaggggcc gacggaacct ggagtggaag    600

gagccgccgt ctatgcgcct gaaggcccgt cctggcaact ctggctcctc cgtgctgacc    660

tgtgctgctt tctccttcta cccaccggag ctcaagtttc gattcctgcg caatgggcta    720

gcctcaggct ccgggaattg cagcactggt ccgaatggag atggctcttt ccacgcatgg    780

tcattgctgg aggttaaacg tggagatgag caccattatc aatgtcaagt ggagcatgag    840

gggctggcac agcctctcac tgtggaccta gattcatcag ccagatcttc tgtgcctgtg    900

gttggaatcg ttcttggttt attgctggtg gtagtggcca tcgcaggcgg tgtgctgttg    960

tggggcagga tgcgcagcgg tctgccagcc ccatggcttt ctctcagcgg cgatgactct   1020

ggtgacctgt tgcctggtgg gaacttgccc ccagaagctg aacctcaagg tgcaaatgcc   1080

tttccagcca cttcctga                                                 1098


<210>  3
<211>  1101
<212>  DNA
<213>  Rattus norvegicus

<400>  3
atggggatgt cccagcccgg ggtcctcctc agcctcttat tggtcctcct gcctcagacc     60

tggggagcgg agccccgtct cccactgatg tatcatcttg cagctgtgtc tgacttatca    120

acggggcttc cctctttctg ggccacgggc tggctgggtg ctcagcaata tctgacctac    180

aacaacctgc ggcaggaggc tgacccctgt ggggcctgga tatgggaaaa ccaggtgtct    240

tggtattggg agaaggagac cacggatctg aaaagcaaag aacagctctt cttggaggcc    300

atcaggaccc tggagaacca aataaatggg accttcacac tgcagggcct gctgggctgt    360

gaactggccc ctgataattc ttcattgccc acggctgtgt ttgccctcaa tggtgaggag    420

ttcatgcggt tcaacccaag aacgggcaac tggagtgggg agtggccgga gacagatatc    480

gttggtaatc tgtggatgaa gcaacctgag gcggccagga aggagagcga gttcctgcta    540

acttcttgtc ctgagcggct gctaggccac ctggagaggg gccgtcagaa cctggagtgg    600

aaggagccgc catctatgcg cctgaaggcc cgtcctggca actctggctc ctcagtactg    660

acctgtgctg ctttctcctt ctacccgccg gagctcaagt ttcgattcct gcgcaatggg    720

ctagcctcag gctctgggaa ttgcagcact ggtcccaatg gtgatggatc tttccatgca    780

tggtcattgc tagaggtcaa acgtggagat gaacaccatt accaatgtca agtggagcat    840

gaggggctgg cccagcctct cactgtggac ctagattcgc ccgccagatc ttctgtgcct    900

gtggtcggaa tcattcttgg tttattgctg gtggtagtgg ccatcgcagg gggtgtgctg    960

ctatggaaca ggatgcgaag tgggctgcca gccccatggc tttctctcag tggtgatgac   1020

tctggcgacc tattgcctgg tgggaacttg cccccggagg ctgaacctca aggtgtaaat   1080

gcctttccgg ccacttcctg a                                             1101


<210>  4
<211>  1071
<212>  DNA
<213>  Sus scrofa

<400>  4
atgcgggtcc cccggcctca gccctggtgg ctcgctctgc tgttcctcct gctgcccgga     60

acgccgagcg cagacaacca ccgctccctc ctgtaccacc tcacggccgt gtccgccccc    120

accccgggcg ctcccgcctt ctgggtgtcg ggctggctgg ggccccagca gtacctgagc    180

tacaataacc tgcgcgccca ggcggagccc tacggcgcct gggtctggga aagccaggtg    240

tcctggtact gggagaagga gaccgcagac ctgaggaaca agcagaagct ctttctcgag    300

gctctcaaaa ccttggagga aggagggccc ttcaccctgc agggccttct gggctgcgaa    360

ttgggccccg acaatgtctc ggtgcctgtg gccacgttcg ccctgaatgg cgaggagttt    420

atgaagttcg acaccaagct gggcacctgg gatggggagt ggcccgaggc ccggaccatt    480

ggctccaagt ggatgcagga gccggacgcg gtcaacaagg agaagacctt cctgctctac    540

tcctgtcccc accggctgct ggggcatctg gagaggggcc ggggcaacct ggagtggaag    600

gagccgccct ccatgcgcat gaaggcccga cccggcaccg cgccgggctt ttccgtgctc    660

acctgcatcg ccttctcctt ctacccaccg gagctgcagc tgcgattcct ccggaacggg    720

ctggcggctg gctccgggga gagtgacatc ggccccaacg gcgacggctc cttccatgcc    780

tggtcgtcgc taacagtcaa gagcggcgac gagcaccact actgctgtgt ggtgcagcac    840

gcggggctgg ctcagcccct caccgtcgag ctggaatccc cagcgaagtc ctccatgcca    900

gtggttggaa tcatggtcgg cttcctactg ctcttgatcg tggctggagg aggagctctg    960

ctgtggagga ggatgaggaa ggggctgcca gccccttgga tctcttttca tggggacgac   1020

gtaggggccc tcctgcccac ccccgacctg gccaaggatg ctgaatctta g            1071


<210>  5
<211>  1065
<212>  DNA
<213>  Bos taurus

<400>  5
atgcggcttc cccggcctca gccctggggg ctcggtctgc tgctcgtcct cctgcctggg     60

gcgctgagcg cagagaacta tcgctcgctc cagtaccact tcaccgccgt gtcggccccc    120

gcagcgggga cccctgcttt ctgggtttcg ggctggctgg ggccccagca gtacctgagc    180

tacaataatc tacgggcgca ggctgagccc tacggcgcgt gggtctggga aagccaggtg    240

tcctggtatt gggagaaaga gaccatggat ctgaggaacc aggagacgct cttcctcgaa    300

gcgctccaag ctttaggcga aggccccttc accatgcagg gcctgttggg ctgcgagttg    360

ggccctgaca atgtctcggt gccggtggcc aagtttgccc tgaacggcga ggagttcatg    420

atgtttgacc ccaagctggg catctgggat ggtgactggc ctgagtcccg gactgtcagt    480

atcaagtgga cgcagcagcc agaggcggtc aacaaggaga agaccttcct cctctactcc    540

tgcccacacc ggctgctggg gcatctggag aggggccggg gcaacctgga gtggaaagag    600

ccaccctcca tgcgcctgaa ggcccgaccc ggcagtcccg gcttctctgt gctcacctgc    660

agcgccttct ccttctaccc acctgagctg aagctgcgct ttctgcggaa cgggctggcc    720

attggctctg gtgagataga catgggcccc aacggcgacg gctccttcta cgcctggtca    780

tcactcacag tcaagagtgg cgacgagcac cactaccgct gcgtggtgca gcacgcgggg    840

ctggcccagc ccctcacggt ggagctggaa tcaccagcca ggacctcggt gccagtggtg    900

gggatcgtca tcggcttatt cctgctcctg acagtggctg cgggaggagc tctcctgtgg    960

agaaggatga ggaaggggct gccagctcct tggatctctt tccgtgggga ggatgtaggg   1020

gccctcctgc ccactcccgg cctgtccaag gatggtgaat cttag                   1065


<210>  6
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct     60

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca    120

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg    180

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg    240

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc    300

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgtaa    360


<210>  7
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  7
atggctcgct cggtgaccct ggtctttctg gtgcttgtct cactgaccgg cctgtatgct     60

atccagaaaa cccctcaaat tcaagtatac tcacgccacc caccggagaa tgggaagccg    120

aacatactga actgctacgt aacacagttc cacccgcctc acattgaaat ccaaatgctg    180

aagaacggga aaaaaattcc taaagtagag atgtcagata tgtccttcag caaggactgg    240

tctttctata tcctggctca cactgaattc acccccactg agactgatac atacgcctgc    300

agagttaagc atgccagtat ggccgagccc aagaccgtct actgggatcg agacatgtga    360


<210>  8
<211>  360
<212>  DNA
<213>  Rattus norvegicus

<400>  8
atggctcgct cggtgaccgt gatctttctg gtgcttgtct ctctggccgt cgtgcttgcc     60

attcagaaaa ctccccaaat tcaagtgtac tctcgccatc caccggagaa tgggaagccc    120

aacttcctca actgctacgt gtctcagttc cacccacctc agatagaaat tgagctactg    180

aagaatggaa agaagatacc aaatatcgag atgtcagatc tgtccttcag caaggactgg    240

tctttctaca tcctggctca cactgaattc acacccaccg agaccgatgt atatgcttgc    300

agagttaaac acgtcactct gaaggagccc aaaaccgtca cctgggaccg agacatgtaa    360


<210>  9
<211>  357
<212>  DNA
<213>  Sus scrofa

<400>  9
atggctcccc tcgtggcctt ggtcctgctc gggctgctct cactgtctgg cctggatgcg     60

gtcgcgcgtc ccccgaaggt tcaggtttac tcacgccacc cagcggaaaa cggaaagcca    120

aattacctga actgctatgt atctgggttc catccgcccc agattgaaat tgatttgctg    180

aaaaacgggg agaagatgaa cgcggagcag tcagacctgt ctttcagcaa ggactggtct    240

ttctaccttc tggtccacac tgagttcact cctaacgctg tggatcagta tagctgccgc    300

gtgaagcacg tgactctcga taagcccaag atagttaagt gggatcgaga ccactaa       357


<210>  10
<211>  357
<212>  DNA
<213>  Bos taurus

<400>  10
atggctcgct tcgtggcctt ggtccttctc gggctgctgt cgctgtctgg actggacgcc     60

atccagcgtc ctccaaagat tcaagtgtac tcaagacacc caccagaaga tggaaagcca    120

aattacctga actgctatgt gtatgggttc catccacccc agattgaaat tgatttgctg    180

aagaatgggg agaagattaa atcggagcag tcagacctgt ctttcagcaa ggactggtct    240

ttctacctgc tgtcccacgc tgagttcact cccaacagca aggatcagta cagctgccga    300

gtgaaacacg ttactttgga acaaccccgg atagttaagt gggatcgaga cctgtaa       357


<210>  11
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  12
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  12

Met Gly Met Pro Leu Pro Trp Ala Leu Ser Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Pro Gln Thr Trp Gly Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu 
            20                  25                  30          


Thr Ala Val Ser Asn Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr 
        35                  40                  45              


Gly Trp Leu Gly Pro Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln 
    50                  55                  60                  


Glu Ala Asp Pro Cys Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp 
65                  70                  75                  80  


Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe 
                85                  90                  95      


Leu Glu Ala Leu Lys Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val 
        115                 120                 125             


Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn 
    130                 135                 140                 


Pro Arg Ile Gly Asn Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val 
145                 150                 155                 160 


Ala Asn Leu Trp Met Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu 
                165                 170                 175     


Phe Leu Leu Asn Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg 
            180                 185                 190         


Gly Arg Arg Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser 
                245                 250                 255     


Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His His 
            260                 265                 270         


Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val 
        275                 280                 285             


Asp Leu Asp Ser Ser Ala Arg Ser Ser Val Pro Val Val Gly Ile Val 
    290                 295                 300                 


Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu Leu 
305                 310                 315                 320 


Trp Gly Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu Ser 
                325                 330                 335     


Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro Glu 
            340                 345                 350         


Ala Glu Pro Gln Gly Ala Asn Ala Phe Pro Ala Thr Ser 
        355                 360                 365 


<210>  13
<211>  366
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Gly Met Ser Gln Pro Gly Val Leu Leu Ser Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Pro Gln Thr Trp Gly Ala Glu Pro Arg Leu Pro Leu Met Tyr His 
            20                  25                  30          


Leu Ala Ala Val Ser Asp Leu Ser Thr Gly Leu Pro Ser Phe Trp Ala 
        35                  40                  45              


Thr Gly Trp Leu Gly Ala Gln Gln Tyr Leu Thr Tyr Asn Asn Leu Arg 
    50                  55                  60                  


Gln Glu Ala Asp Pro Cys Gly Ala Trp Ile Trp Glu Asn Gln Val Ser 
65                  70                  75                  80  


Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu 
                85                  90                  95      


Phe Leu Glu Ala Ile Arg Thr Leu Glu Asn Gln Ile Asn Gly Thr Phe 
            100                 105                 110         


Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Pro Asp Asn Ser Ser 
        115                 120                 125             


Leu Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Arg Phe 
    130                 135                 140                 


Asn Pro Arg Thr Gly Asn Trp Ser Gly Glu Trp Pro Glu Thr Asp Ile 
145                 150                 155                 160 


Val Gly Asn Leu Trp Met Lys Gln Pro Glu Ala Ala Arg Lys Glu Ser 
                165                 170                 175     


Glu Phe Leu Leu Thr Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu 
            180                 185                 190         


Arg Gly Arg Gln Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu 
        195                 200                 205             


Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala 
    210                 215                 220                 


Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly 
225                 230                 235                 240 


Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly 
                245                 250                 255     


Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His 
            260                 265                 270         


His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr 
        275                 280                 285             


Val Asp Leu Asp Ser Pro Ala Arg Ser Ser Val Pro Val Val Gly Ile 
    290                 295                 300                 


Ile Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu 
305                 310                 315                 320 


Leu Trp Asn Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu 
                325                 330                 335     


Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro 
            340                 345                 350         


Glu Ala Glu Pro Gln Gly Val Asn Ala Phe Pro Ala Thr Ser 
        355                 360                 365     


<210>  14
<211>  356
<212>  PRT
<213>  Sus scrofa

<400>  14

Met Arg Val Pro Arg Pro Gln Pro Trp Trp Leu Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Pro Gly Thr Pro Ser Ala Asp Asn His Arg Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ala Pro Thr Pro Gly Ala Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Asn Leu 
    50                  55                  60                  


Arg Ala Gln Ala Glu Pro Tyr Gly Ala Trp Val Trp Glu Ser Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Ala Asp Leu Arg Asn Lys Gln Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Leu Lys Thr Leu Glu Glu Gly Gly Pro Phe Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Val Ser Val 
        115                 120                 125             


Pro Val Ala Thr Phe Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asp 
    130                 135                 140                 


Thr Lys Leu Gly Thr Trp Asp Gly Glu Trp Pro Glu Ala Arg Thr Ile 
145                 150                 155                 160 


Gly Ser Lys Trp Met Gln Glu Pro Asp Ala Val Asn Lys Glu Lys Thr 
                165                 170                 175     


Phe Leu Leu Tyr Ser Cys Pro His Arg Leu Leu Gly His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Met Lys 
        195                 200                 205             


Ala Arg Pro Gly Thr Ala Pro Gly Phe Ser Val Leu Thr Cys Ile Ala 
    210                 215                 220                 


Phe Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly 
225                 230                 235                 240 


Leu Ala Ala Gly Ser Gly Glu Ser Asp Ile Gly Pro Asn Gly Asp Gly 
                245                 250                 255     


Ser Phe His Ala Trp Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His 
            260                 265                 270         


His Tyr Cys Cys Val Val Gln His Ala Gly Leu Ala Gln Pro Leu Thr 
        275                 280                 285             


Val Glu Leu Glu Ser Pro Ala Lys Ser Ser Met Pro Val Val Gly Ile 
    290                 295                 300                 


Met Val Gly Phe Leu Leu Leu Leu Ile Val Ala Gly Gly Gly Ala Leu 
305                 310                 315                 320 


Leu Trp Arg Arg Met Arg Lys Gly Leu Pro Ala Pro Trp Ile Ser Phe 
                325                 330                 335     


His Gly Asp Asp Val Gly Ala Leu Leu Pro Thr Pro Asp Leu Ala Lys 
            340                 345                 350         


Asp Ala Glu Ser 
        355     


<210>  15
<211>  354
<212>  PRT
<213>  Bos taurus

<400>  15

Met Arg Leu Pro Arg Pro Gln Pro Trp Gly Leu Gly Leu Leu Leu Val 
1               5                   10                  15      


Leu Leu Pro Gly Ala Leu Ser Ala Glu Asn Tyr Arg Ser Leu Gln Tyr 
            20                  25                  30          


His Phe Thr Ala Val Ser Ala Pro Ala Ala Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Asn Leu 
    50                  55                  60                  


Arg Ala Gln Ala Glu Pro Tyr Gly Ala Trp Val Trp Glu Ser Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Met Asp Leu Arg Asn Gln Glu Thr 
                85                  90                  95      


Leu Phe Leu Glu Ala Leu Gln Ala Leu Gly Glu Gly Pro Phe Thr Met 
            100                 105                 110         


Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Val Ser Val Pro 
        115                 120                 125             


Val Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Met Phe Asp Pro 
    130                 135                 140                 


Lys Leu Gly Ile Trp Asp Gly Asp Trp Pro Glu Ser Arg Thr Val Ser 
145                 150                 155                 160 


Ile Lys Trp Thr Gln Gln Pro Glu Ala Val Asn Lys Glu Lys Thr Phe 
                165                 170                 175     


Leu Leu Tyr Ser Cys Pro His Arg Leu Leu Gly His Leu Glu Arg Gly 
            180                 185                 190         


Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys Ala 
        195                 200                 205             


Arg Pro Gly Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe Ser 
    210                 215                 220                 


Phe Tyr Pro Pro Glu Leu Lys Leu Arg Phe Leu Arg Asn Gly Leu Ala 
225                 230                 235                 240 


Ile Gly Ser Gly Glu Ile Asp Met Gly Pro Asn Gly Asp Gly Ser Phe 
                245                 250                 255     


Tyr Ala Trp Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His Tyr 
            260                 265                 270         


Arg Cys Val Val Gln His Ala Gly Leu Ala Gln Pro Leu Thr Val Glu 
        275                 280                 285             


Leu Glu Ser Pro Ala Arg Thr Ser Val Pro Val Val Gly Ile Val Ile 
    290                 295                 300                 


Gly Leu Phe Leu Leu Leu Thr Val Ala Ala Gly Gly Ala Leu Leu Trp 
305                 310                 315                 320 


Arg Arg Met Arg Lys Gly Leu Pro Ala Pro Trp Ile Ser Phe Arg Gly 
                325                 330                 335     


Glu Asp Val Gly Ala Leu Leu Pro Thr Pro Gly Leu Ser Lys Asp Gly 
            340                 345                 350         


Glu Ser 
        


<210>  16
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Gly Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Gln Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  17
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr 
        35                  40                  45              


Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr 
            100                 105                 110         


Val Tyr Trp Asp Arg Asp Met 
        115                 


<210>  18
<211>  119
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Ala Arg Ser Val Thr Val Ile Phe Leu Val Leu Val Ser Leu Ala 
1               5                   10                  15      


Val Val Leu Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gln Phe His Pro Pro Gln Ile Glu Ile Glu Leu Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Asn Ile Glu Met Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Val Tyr Ala Cys Arg Val Lys His Val Thr Leu Lys Glu Pro Lys Thr 
            100                 105                 110         


Val Thr Trp Asp Arg Asp Met 
        115                 


<210>  19
<211>  118
<212>  PRT
<213>  Sus scrofa

<400>  19

Met Ala Pro Leu Val Ala Leu Val Leu Leu Gly Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Asp Ala Val Ala Arg Pro Pro Lys Val Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Pro Asn Tyr Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Pro Gln Ile Glu Ile Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Met Asn Ala Glu Gln Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser 
65                  70                  75                  80  


Phe Tyr Leu Leu Val His Thr Glu Phe Thr Pro Asn Ala Val Asp Gln 
                85                  90                  95      


Tyr Ser Cys Arg Val Lys His Val Thr Leu Asp Lys Pro Lys Ile Val 
            100                 105                 110         


Lys Trp Asp Arg Asp His 
        115             


<210>  20
<211>  118
<212>  PRT
<213>  Bos taurus

<400>  20

Met Ala Arg Phe Val Ala Leu Val Leu Leu Gly Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Asp Ala Ile Gln Arg Pro Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asp Gly Lys Pro Asn Tyr Leu Asn Cys Tyr Val Tyr 
        35                  40                  45              


Gly Phe His Pro Pro Gln Ile Glu Ile Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Ile Lys Ser Glu Gln Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser 
65                  70                  75                  80  


Phe Tyr Leu Leu Ser His Ala Glu Phe Thr Pro Asn Ser Lys Asp Gln 
                85                  90                  95      


Tyr Ser Cys Arg Val Lys His Val Thr Leu Glu Gln Pro Arg Ile Val 
            100                 105                 110         


Lys Trp Asp Arg Asp Leu 
        115             


<210>  21
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  22
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide linker

<400>  22

Gly Gly Gly Gly Ser 
1               5


<210>  23
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-KPNI-BSIWI-F

<400>  23
atcaggtacc cgtacggccg ccaccatggg ggtcccgcgg cctc                      44


<210>  24
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-2xLINKER-BAMHI-R

<400>  24
agtcggatcc gcctccgccg ctgcctcctc cgccggagga cttggctgga gattcc         56


<210>  25
<211>  71
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-3xLINKER-BAMHI-R

<400>  25
agtcggatcc tcctccgccg ctgcctcctc cgccgctgcc tcctccgccg gaggacttgg     60

ctggagattc c                                                          71


<210>  26
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-BAMHI-F

<400>  26
agtcggatcc atccagcgta ctccaaagat tcagg                                35


<210>  27
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-NOTI-MFEI-R

<400>  27
atcggcggcc gccaattgtt acatgtctcg atcccactta actatcttgg                50


<210>  28
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-BAMH1-2XLINKER-F

<400>  28
agtcggatcc ggcggaggag gcagcggcgg aggcggctcc atccagcgta ctccaaagat     60

tcagg                                                                 65


<210>  29
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-KPNI-BSIWI-F

<400>  29
caggtacccg tacggccgcc accatgtctc gctccgtggc cttag                     45


<210>  30
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-2xLINKER-BAMHI-R

<400>  30
atcaggatcc gcctccgccg ctgcctcctc cgcccatgtc tcgatcccac ttaactatct     60

tgg                                                                   63


<210>  31
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-3xLINKER-BAMHI-R

<400>  31
atcaggatcc gcctccgccg ctgcctcctc cgccgctgcc tcctccgccc atgtctcgat     60

cccacttaac tatcttgg                                                   78


<210>  32
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-BCLI-F

<400>  32
acgtactgat cagcagaaag ccacctctcc ctcc                                 34


<210>  33
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-NOTI-MFEI-R

<400>  33
atcggcggcc gccaattgtt aggaggactt ggctggagat tcc                       43


<210>  34
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-BCL1-2XLINKER-F

<400>  34
atcagctgat caggcggagg aggcagcggc ggaggaggca gcgcagaaag ccacctctcc     60

ctcc                                                                  64


<210>  35
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-BCL1-F2

<400>  35
atggaatgat cattccacgc ctcgtcgtca c                                    31


<210>  36
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-XBAI-R

<400>  36
agcatctaga gtaaacctga atctttggag tacgctg                              37


<210>  37
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  B2M-XBA1-F

<400>  37
tcgttctaga catccagcag agaatggaaa gtc                                  33


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  FCRN-XBA1-R

<400>  38
ccctctagac tcgagcggcc                                                 20



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