                         SEQUENCE LISTING

<110>  William Beaumont Hospital
        Akervall, Jan
 
<120>  METHODS OF USING BIOMARKERS

<130>  10546-237

<140>  Not yet assigned
<141>  2009-10-22

<150>  US 61/109,331
<151>  2008-10-29

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  5128
<212>  DNA
<213>  Homo sapiens

<400>  1
ccgagtgcct cgcagcccct cccgaggcgc agccgccaga ccagtggagc cggggcgcag       60

ggcgggggcg gaggcgccgg ggcgggggat gcggggccgc ggcgcagccc cccggccctg      120

agagcgagga cagcgccgcc cggcccgcag ccgtcgccgc ttctccacct cggcccgtgg      180

agccggggcg tccgggcgta gccctcgctc gcctgggtca gggggtgcgc gtcgggggag      240

gcagaagcca tggatcccgg gcagcagccg ccgcctcaac cggcccccca gggccaaggg      300

cagccgcctt cgcagccccc gcaggggcag ggcccgccgt ccggacccgg gcaaccggca      360

cccgcggcga cccaggcggc gccgcaggca ccccccgccg ggcatcagat cgtgcacgtc      420

cgcggggact cggagaccga cctggaggcg ctcttcaacg ccgtcatgaa ccccaagacg      480

gccaacgtgc cccagaccgt gcccatgagg ctccggaagc tgcccgactc cttcttcaag      540

ccgccggagc ccaaatccca ctcccgacag gccagtactg atgcaggcac tgcaggagcc      600

ctgactccac agcatgttcg agctcattcc tctccagctt ctctgcagtt gggagctgtt      660

tctcctggga cactgacccc cactggagta gtctctggcc cagcagctac acccacagct      720

cagcatcttc gacagtcttc ttttgagata cctgatgatg tacctctgcc agcaggttgg      780

gagatggcaa agacatcttc tggtcagaga tacttcttaa atcacatcga tcagacaaca      840

acatggcagg accccaggaa ggccatgctg tcccagatga acgtcacagc ccccaccagt      900

ccaccagtgc agcagaatat gatgaactcg gcttcagcca tgaaccagag aatcagtcag      960

agtgctccag tgaaacagcc accacccctg gctccccaga gcccacaggg aggcgtcatg     1020

ggtggcagca actccaacca gcagcaacag atgcgactgc agcaactgca gatggagaag     1080

gagaggctgc ggctgaaaca gcaagaactg cttcggcagg tgaggccaca ggagttagcc     1140

ctgcgtagcc agttaccaac actggagcag gatggtggga ctcaaaatcc agtgtcttct     1200

cccgggatgt ctcaggaatt gagaacaatg acgaccaata gctcagatcc tttccttaac     1260

agtggcacct atcactctcg agatgagagt acagacagtg gactaagcat gagcagctac     1320

agtgtccctc gaaccccaga tgacttcctg aacagtgtgg atgagatgga tacaggtgat     1380

actatcaacc aaagcaccct gccctcacag cagaaccgtt tcccagacta ccttgaagcc     1440

attcctggga caaatgtgga ccttggaaca ctggaaggag atggaatgaa catagaagga     1500

gaggagctga tgccaagtct gcaggaagct ttgagttctg acatccttaa tgacatggag     1560

tctgttttgg ctgccaccaa gctagataaa gaaagctttc ttacatggtt atagagccct     1620

caggcagact gaattctaaa tctgtgaagg atctaaggag acacatgcac cggaaatttc     1680

cataagccag ttgcagtttt caggctaata cagaaaaaga tgaacaaacg tccagcaaga     1740

tactttaatc ctctattttg ctcttccttg tccattgctg ctgttaatgt attgctgacc     1800

tctttcacag ttggctctaa agaatcaaaa gaaaaaaact ttttatttct tttgctatta     1860

aaactactgt tcattttggg ggctggggga agtgagcctg tttggatgat ggatgccatt     1920

ccttttgccc agttaaatgt tcaccaatca ttttaactaa atactcagac ttagaagtca     1980

gatgcttcat gtcacagcat ttagtttgtt caacagttgt ttcttcagct tcctttgtcc     2040

agtggaaaaa catgatttac tggtctgaca agccaaaaat gttatatctg atattaaata     2100

cttaatgctg atttgaagag atagctgaaa ccaaggctga agactgtttt actttcagta     2160

ttttcttttc ctcctagtgc tatcattagt cacataatga ccttgatttt attttaggag     2220

cttataaggc atgagacaat ttccatataa atatattaat tattgccaca tactctaata     2280

tagattttgg tggataattt tgtgggtgtg cattttgttc tgttttgttg ggttttttgt     2340

tttttttgtt tttggcaggg tcggtggggg ggttggttgg ttggttggtt ttgtcggaac     2400

ctaggcaaat gaccatatta gtgaatctgt taatagttgt agcttgggat ggttattgta     2460

gttgttttgg taaaatcttc atttcctggt tttttttacc accttattta aatctcgatt     2520

atctgctctc tcttttatat acatacacac acccaaacat aacatttata atagtgtggt     2580

agtggaatgt atcctttttt aggtttccct gctttccagt taatttttaa aatggtagcg     2640

ctttgtatgc atttagaata catgactagt agtttatatt tcactggtag tttaaatctg     2700

gttggggcag tctgcagatg tttgaagtag tttagtgttc tagaaagagc tattactgtg     2760

gatagtgcct aggggagtgc tccacgccct ctgggcatac ggtagatatt atctgatgaa     2820

ttggaaagga gcaaaccaga aatggcttta ttttctccct tggactaatt tttaagtctc     2880

gattggaatt cagtgagtag gttcataatg tgcatgacag aaataagctt tatagtggtt     2940

taccttcatt tagctttgga agttttcttt gccttagttt tggaagtaaa ttctagtttg     3000

tagttctcat ttgtaatgaa cacattaacg actagattaa aatattgcct tcaagattgt     3060

tcttacttac aagacttgct cctacttcta tgctgaaaat tgaccctgga tagaatacta     3120

taaggttttg agttagctgg aaaagtgatc agattaataa atgtatattg gtagttgaat     3180

ttagcaaaga aatagagata atcatgatta tacctttatt tttacaggaa gagatgatgt     3240

aactagagta tgtgtctaca ggagtaataa tggtttccaa agagtatttt ttaaaggaac     3300

aaaacgagca tgaattaact cttcaatata agctatgaag taatagttgg ttgtgaatta     3360

aagtggcacc agctagcacc tctgtgtttt aagggtcttt caatgtttct agaataagcc     3420

cttattttca agggttcata acaggcataa aatctcttct cctggcaaaa gctgctatga     3480

aaagcctcag cttgggaaga tagatttttt tccccccaat tacaaaatct aagtattttg     3540

gcccttcaat ttggaggagg gcaaaagttg gaagtaagaa gttttatttt aagtactttc     3600

agtgctcaaa aaaatgcaat cactgtgttg tatataatag ttcataggtt gatcactcat     3660

aataattgac tctaaggctt ttattaagaa aacagcagaa agattaaatc ttgaattaag     3720

tctgggggga aatggccact gcagatggag ttttagagta gtaatgaaat tctacctaga     3780

atgcaaaatt gggtatatga attacatagc atgttgttgg gatttttttt aatgtgcaga     3840

agatcaaagc tacttggaag gagtgcctat aatttgccag tagccacaga ttaagattat     3900

atcttatata tcagcagatt agctttagct tagggggagg gtgggaaagt ttgggggggg     3960

ggttgtgaag atttaggggg accttgatag agaactttat aaacttcttt ctctttaata     4020

aagacttgtc ttacaccgtg ctgccattaa aggcagctgt tctagagttt cagtcaccta     4080

agtacaccca caaaacaata tgaatatgga gatcttcctt tacccctcaa ctttaatttg     4140

cccagttata cctcagtgtt gtagcagtac tgtgatacct ggcacagtgc tttgatctta     4200

cgatgccctc tgtactgacc tgaaggagac ctaagagtcc tttccctttt tgagtttgaa     4260

tcatagcctt gatgtggtct cttgttttat gtccttgttc ctaatgtaaa agtgcttaac     4320

tgcttcttgg ttgtattggg tagcattggg ataagatttt aactgggtat tcttgaattg     4380

cttttacaat aaaccaattt tataatcttt aaatttatca actttttaca tttgtgttat     4440

tttcagtcag ggcttcttag atctacttat ggttgatgga gcacattgat ttggagtttc     4500

agatcttcca aagcactatt tgttgtaata acttttctaa atgtagtgcc tttaaaggaa     4560

aaatgaacac agggaagtga ctttgctaca aataatgttg ctgtgttaag tattcatatt     4620

aaatacatgc cttctatatg gaacatggca gaaagactga aaaataacag taattaattg     4680

tgtaattcag aattcatacc aatcagtgtt gaaactcaaa cattgcaaaa gtgggtggca     4740

atattcagtg cttaacactt ttctagcgtt ggtacatctg agaaatgagt gctcaggtgg     4800

attttatcct cgcaagcatg ttgttataag aattgtgggt gtgcctatca taacaattgt     4860

tttctgtatc ttgaaaaagt attctccaca ttttaaatgt tttatattag agaattcttt     4920

aatgcacact tgtcaaatat atatatatag taccaatgtt acctttttat tttttgtttt     4980

agatgtaaga gcatgctcat atgttaggta cttacataaa ttgttacatt attttttctt     5040

atgtaatacc tttttgtttg tttatgtggt tcaaatatat tctttcctta aaaaaaaaaa     5100

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                        5128


<210>  2
<211>  6030
<212>  DNA
<213>  Homo sapiens

<400>  2
gttggccccc gttacttttc ctctgggaaa tatggcgcac gctgggagaa cagggtacga       60

taaccgggag atagtgatga agtacatcca ttataagctg tcgcagaggg gctacgagtg      120

ggatgcggga gatgtgggcg ccgcgccccc gggggccgcc cccgcgccgg gcatcttctc      180

ctcgcagccc gggcacacgc cccatacagc cgcatcccgg gacccggtcg ccaggacctc      240

gccgctgcag accccggctg cccccggcgc cgccgcgggg cctgcgctca gcccggtgcc      300

acctgtggtc cacctgaccc tccgccaggc cggcgacgac ttctcccgcc gctaccgccg      360

cgacttcgcc gagatgtcca ggcagctgca cctgacgccc ttcaccgcgc ggggacgctt      420

tgccacggtg gtggaggagc tcttcaggga cggggtgaac tgggggagga ttgtggcctt      480

ctttgagttc ggtggggtca tgtgtgtgga gagcgtcaac cgggagatgt cgcccctggt      540

ggacaacatc gccctgtgga tgactgagta cctgaaccgg cacctgcaca cctggatcca      600

ggataacgga ggctgggatg cctttgtgga actgtacggc cccagcatgc ggcctctgtt      660

tgatttctcc tggctgtctc tgaagactct gctcagtttg gccctggtgg gagcttgcat      720

caccctgggt gcctatctgg gccacaagtg aagtcaacat gcctgcccca aacaaatatg      780

caaaaggttc actaaagcag tagaaataat atgcattgtc agtgatgttc catgaaacaa      840

agctgcaggc tgtttaagaa aaaataacac acatataaac atcacacaca cagacagaca      900

cacacacaca caacaattaa cagtcttcag gcaaaacgtc gaatcagcta tttactgcca      960

aagggaaata tcatttattt tttacattat taagaaaaaa agatttattt atttaagaca     1020

gtcccatcaa aactcctgtc tttggaaatc cgaccactaa ttgccaagca ccgcttcgtg     1080

tggctccacc tggatgttct gtgcctgtaa acatagattc gctttccatg ttgttggccg     1140

gatcaccatc tgaagagcag acggatggaa aaaggacctg atcattgggg aagctggctt     1200

tctggctgct ggaggctggg gagaaggtgt tcattcactt gcatttcttt gccctggggg     1260

ctgtgatatt aacagaggga gggttcctgt ggggggaagt ccatgcctcc ctggcctgaa     1320

gaagagactc tttgcatatg actcacatga tgcatacctg gtgggaggaa aagagttggg     1380

aacttcagat ggacctagta cccactgaga tttccacgcc gaaggacagc gatgggaaaa     1440

atgcccttaa atcataggaa agtatttttt taagctacca attgtgccga gaaaagcatt     1500

ttagcaattt atacaatatc atccagtacc ttaagccctg attgtgtata ttcatatatt     1560

ttggatacgc accccccaac tcccaatact ggctctgtct gagtaagaaa cagaatcctc     1620

tggaacttga ggaagtgaac atttcggtga cttccgcatc aggaaggcta gagttaccca     1680

gagcatcagg ccgccacaag tgcctgcttt taggagaccg aagtccgcag aacctgcctg     1740

tgtcccagct tggaggcctg gtcctggaac tgagccgggg ccctcactgg cctcctccag     1800

ggatgatcaa cagggcagtg tggtctccga atgtctggaa gctgatggag ctcagaattc     1860

cactgtcaag aaagagcagt agaggggtgt ggctgggcct gtcaccctgg ggccctccag     1920

gtaggcccgt tttcacgtgg agcatgggag ccacgaccct tcttaagaca tgtatcactg     1980

tagagggaag gaacagaggc cctgggccct tcctatcaga aggacatggt gaaggctggg     2040

aacgtgagga gaggcaatgg ccacggccca ttttggctgt agcacatggc acgttggctg     2100

tgtggccttg gcccacctgt gagtttaaag caaggcttta aatgactttg gagagggtca     2160

caaatcctaa aagaagcatt gaagtgaggt gtcatggatt aattgacccc tgtctatgga     2220

attacatgta aaacattatc ttgtcactgt agtttggttt tatttgaaaa cctgacaaaa     2280

aaaaagttcc aggtgtggaa tatgggggtt atctgtacat cctggggcat taaaaaaaaa     2340

atcaatggtg gggaactata aagaagtaac aaaagaagtg acatcttcag caaataaact     2400

aggaaatttt tttttcttcc agtttagaat cagccttgaa acattgatgg aataactctg     2460

tggcattatt gcattatata ccatttatct gtattaactt tggaatgtac tctgttcaat     2520

gtttaatgct gtggttgata tttcgaaagc tgctttaaaa aaatacatgc atctcagcgt     2580

ttttttgttt ttaattgtat ttagttatgg cctatacact atttgtgagc aaaggtgatc     2640

gttttctgtt tgagattttt atctcttgat tcttcaaaag cattctgaga aggtgagata     2700

agccctgagt ctcagctacc taagaaaaac ctggatgtca ctggccactg aggagctttg     2760

tttcaaccaa gtcatgtgca tttccacgtc aacagaattg tttattgtga cagttatatc     2820

tgttgtccct ttgaccttgt ttcttgaagg tttcctcgtc cctgggcaat tccgcattta     2880

attcatggta ttcaggatta catgcatgtt tggttaaacc catgagattc attcagttaa     2940

aaatccagat ggcaaatgac cagcagattc aaatctatgg tggtttgacc tttagagagt     3000

tgctttacgt ggcctgtttc aacacagacc cacccagagc cctcctgccc tccttccgcg     3060

ggggctttct catggctgtc cttcagggtc ttcctgaaat gcagtggtgc ttacgctcca     3120

ccaagaaagc aggaaacctg tggtatgaag ccagacctcc ccggcgggcc tcagggaaca     3180

gaatgatcag acctttgaat gattctaatt tttaagcaaa atattatttt atgaaaggtt     3240

tacattgtca aagtgatgaa tatggaatat ccaatcctgt gctgctatcc tgccaaaatc     3300

attttaatgg agtcagtttg cagtatgctc cacgtggtaa gatcctccaa gctgctttag     3360

aagtaacaat gaagaacgtg gacgctttta atataaagcc tgttttgtct tctgttgttg     3420

ttcaaacggg attcacagag tatttgaaaa atgtatatat attaagaggt cacgggggct     3480

aattgctggc tggctgcctt ttgctgtggg gttttgttac ctggttttaa taacagtaaa     3540

tgtgcccagc ctcttggccc cagaactgta cagtattgtg gctgcacttg ctctaagagt     3600

agttgatgtt gcattttcct tattgttaaa aacatgttag aagcaatgaa tgtatataaa     3660

agcctcaact agtcattttt ttctcctctt cttttttttc attatatcta attattttgc     3720

agttgggcaa cagagaacca tccctatttt gtattgaaga gggattcaca tctgcatctt     3780

aactgctctt tatgaatgaa aaaacagtcc tctgtatgta ctcctcttta cactggccag     3840

ggtcagagtt aaatagagta tatgcacttt ccaaattggg gacaagggct ctaaaaaaag     3900

ccccaaaagg agaagaacat ctgagaacct cctcggccct cccagtccct cgctgcacaa     3960

atactccgca agagaggcca gaatgacagc tgacagggtc tatggccatc gggtcgtctc     4020

cgaagatttg gcaggggcag aaaactctgg caggcttaag atttggaata aagtcacaga     4080

atcaaggaag cacctcaatt tagttcaaac aagacgccaa cattctctcc acagctcact     4140

tacctctctg tgttcagatg tggccttcca tttatatgtg atctttgttt tattagtaaa     4200

tgcttatcat ctaaagatgt agctctggcc cagtgggaaa aattaggaag tgattataaa     4260

tcgagaggag ttataataat caagattaaa tgtaaataat cagggcaatc ccaacacatg     4320

tctagctttc acctccagga tctattgagt gaacagaatt gcaaatagtc tctatttgta     4380

attgaactta tcctaaaaca aatagtttat aaatgtgaac ttaaactcta attaattcca     4440

actgtacttt taaggcagtg gctgttttta gactttctta tcacttatag ttagtaatgt     4500

acacctactc tatcagagaa aaacaggaaa ggctcgaaat acaagccatt ctaaggaaat     4560

tagggagtca gttgaaattc tattctgatc ttattctgtg gtgtcttttg cagcccagac     4620

aaatgtggtt acacactttt taagaaatac aattctacat tgtcaagctt atgaaggttc     4680

caatcagatc tttattgtta ttcaatttgg atctttcagg gatttttttt ttaaattatt     4740

atgggacaaa ggacatttgt tggaggggtg ggagggagga acaattttta aatataaaac     4800

attcccaagt ttggatcagg gagttggaag ttttcagaat aaccagaact aagggtatga     4860

aggacctgta ttggggtcga tgtgatgcct ctgcgaagaa ccttgtgtga caaatgagaa     4920

acattttgaa gtttgtggta cgacctttag attccagaga catcagcatg gctcaaagtg     4980

cagctccgtt tggcagtgca atggtataaa tttcaagctg gatatgtcta atgggtattt     5040

aaacaataaa tgtgcagttt taactaacag gatatttaat gacaaccttc tggttggtag     5100

ggacatctgt ttctaaatgt ttattatgta caatacagaa aaaaatttta taaaattaag     5160

caatgtgaaa ctgaattgga gagtgataat acaagtcctt tagtcttacc cagtgaatca     5220

ttctgttcca tgtctttgga caaccatgac cttggacaat catgaaatat gcatctcact     5280

ggatgcaaag aaaatcagat ggagcatgaa tggtactgta ccggttcatc tggactgccc     5340

cagaaaaata acttcaagca aacatcctat caacaacaag gttgttctgc ataccaagct     5400

gagcacagaa gatgggaaca ctggtggagg atggaaaggc tcgctcaatc aagaaaattc     5460

tgagactatt aataaataag actgtagtgt agatactgag taaatccatg cacctaaacc     5520

ttttggaaaa tctgccgtgg gccctccaga tagctcattt cattaagttt ttccctccaa     5580

ggtagaattt gcaagagtga cagtggattg catttctttt ggggaagctt tcttttggtg     5640

gttttgttta ttataccttc ttaagttttc aaccaaggtt tgcttttgtt ttgagttact     5700

ggggttattt ttgttttaaa taaaaataag tgtacaataa gtgtttttgt attgaaagct     5760

tttgttatca agattttcat acttttacct tccatggctc tttttaagat tgatactttt     5820

aagaggtggc tgatattctg caacactgta cacataaaaa atacggtaag gatactttac     5880

atggttaagg taaagtaagt ctccagttgg ccaccattag ctataatggc actttgtttg     5940

tgttgttgga aaaagtcaca ttgccattaa actttccttg tctgtctagt taatattgtg     6000

aagaaaaata aagtacagtg tgagatactg                                      6030


<210>  3
<211>  1948
<212>  DNA
<213>  Homo sapiens

<400>  3
gcggggagct cggatgtccg gtttcctgtg aggcttttac ctgacacccg ccgcctttcc       60

ccggcactgg ctgggagggc gccctgcaaa gttgggaacg cggagccccg gacccgctcc      120

cgccgcctcc ggctcgccca gggggggtcg ccgggaggag cccgggggag agggaccagg      180

aggggcccgc ggcctcgcag gggcgcccgc gcccccaccc ctgcccccgc cagcggaccg      240

gtcccccacc cccggtcctt ccaccatgca cttgctgggc ttcttctctg tggcgtgttc      300

tctgctcgcc gctgcgctgc tcccgggtcc tcgcgaggcg cccgccgccg ccgccgcctt      360

cgagtccgga ctcgacctct cggacgcgga gcccgacgcg ggcgaggcca cggcttatgc      420

aagcaaagat ctggaggagc agttacggtc tgtgtccagt gtagatgaac tcatgactgt      480

actctaccca gaatattgga aaatgtacaa gtgtcagcta aggaaaggag gctggcaaca      540

taacagagaa caggccaacc tcaactcaag gacagaagag actataaaat ttgctgcagc      600

acattataat acagagatct tgaaaagtat tgataatgag tggagaaaga ctcaatgcat      660

gccacgggag gtgtgtatag atgtggggaa ggagtttgga gtcgcgacaa acaccttctt      720

taaacctcca tgtgtgtccg tctacagatg tgggggttgc tgcaatagtg aggggctgca      780

gtgcatgaac accagcacga gctacctcag caagacgtta tttgaaatta cagtgcctct      840

ctctcaaggc cccaaaccag taacaatcag ttttgccaat cacacttcct gccgatgcat      900

gtctaaactg gatgtttaca gacaagttca ttccattatt agacgttccc tgccagcaac      960

actaccacag tgtcaggcag cgaacaagac ctgccccacc aattacatgt ggaataatca     1020

catctgcaga tgcctggctc aggaagattt tatgttttcc tcggatgctg gagatgactc     1080

aacagatgga ttccatgaca tctgtggacc aaacaaggag ctggatgaag agacctgtca     1140

gtgtgtctgc agagcggggc ttcggcctgc cagctgtgga ccccacaaag aactagacag     1200

aaactcatgc cagtgtgtct gtaaaaacaa actcttcccc agccaatgtg gggccaaccg     1260

agaatttgat gaaaacacat gccagtgtgt atgtaaaaga acctgcccca gaaatcaacc     1320

cctaaatcct ggaaaatgtg cctgtgaatg tacagaaagt ccacagaaat gcttgttaaa     1380

aggaaagaag ttccaccacc aaacatgcag ctgttacaga cggccatgta cgaaccgcca     1440

gaaggcttgt gagccaggat tttcatatag tgaagaagtg tgtcgttgtg tcccttcata     1500

ttggaaaaga ccacaaatga gctaagattg tactgttttc cagttcatcg attttctatt     1560

atggaaaact gtgttgccac agtagaactg tctgtgaaca gagagaccct tgtgggtcca     1620

tgctaacaaa gacaaaagtc tgtctttcct gaaccatgtg gataacttta cagaaatgga     1680

ctggagctca tctgcaaaag gcctcttgta aagactggtt ttctgccaat gaccaaacag     1740

ccaagatttt cctcttgtga tttctttaaa agaatgacta tataatttat ttccactaaa     1800

aatattgttt ctgcattcat ttttatagca acaacaattg gtaaaactca ctgtgatcaa     1860

tatttttata tcatgcaaaa tatgtttaaa ataaaatgaa aattgtatta taaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                        1948


<210>  4
<211>  6641
<212>  DNA
<213>  Homo sapiens

<400>  4
gccctcgccg cccgcggcgc cccgagcgct ttgtgagcag atgcggagcc gagtggaggg       60

cgcgagccag atgcggggcg acagctgact tgctgagagg aggcggggag gcgcggagcg      120

cgcgtgtggt ccttgcgccg ctgacttctc cactggttcc tgggcaccga aagataaacc      180

tctcataatg aaggcccccg ctgtgcttgc acctggcatc ctcgtgctcc tgtttacctt      240

ggtgcagagg agcaatgggg agtgtaaaga ggcactagca aagtccgaga tgaatgtgaa      300

tatgaagtat cagcttccca acttcaccgc ggaaacaccc atccagaatg tcattctaca      360

tgagcatcac attttccttg gtgccactaa ctacatttat gttttaaatg aggaagacct      420

tcagaaggtt gctgagtaca agactgggcc tgtgctggaa cacccagatt gtttcccatg      480

tcaggactgc agcagcaaag ccaatttatc aggaggtgtt tggaaagata acatcaacat      540

ggctctagtt gtcgacacct actatgatga tcaactcatt agctgtggca gcgtcaacag      600

agggacctgc cagcgacatg tctttcccca caatcatact gctgacatac agtcggaggt      660

tcactgcata ttctccccac agatagaaga gcccagccag tgtcctgact gtgtggtgag      720

cgccctggga gccaaagtcc tttcatctgt aaaggaccgg ttcatcaact tctttgtagg      780

caataccata aattcttctt atttcccaga tcatccattg cattcgatat cagtgagaag      840

gctaaaggaa acgaaagatg gttttatgtt tttgacggac cagtcctaca ttgatgtttt      900

acctgagttc agagattctt accccattaa gtatgtccat gcctttgaaa gcaacaattt      960

tatttacttc ttgacggtcc aaagggaaac tctagatgct cagacttttc acacaagaat     1020

aatcaggttc tgttccataa actctggatt gcattcctac atggaaatgc ctctggagtg     1080

tattctcaca gaaaagagaa aaaagagatc cacaaagaag gaagtgttta atatacttca     1140

ggctgcgtat gtcagcaagc ctggggccca gcttgctaga caaataggag ccagcctgaa     1200

tgatgacatt cttttcgggg tgttcgcaca aagcaagcca gattctgccg aaccaatgga     1260

tcgatctgcc atgtgtgcat tccctatcaa atatgtcaac gacttcttca acaagatcgt     1320

caacaaaaac aatgtgagat gtctccagca tttttacgga cccaatcatg agcactgctt     1380

taataggaca cttctgagaa attcatcagg ctgtgaagcg cgccgtgatg aatatcgaac     1440

agagtttacc acagctttgc agcgcgttga cttattcatg ggtcaattca gcgaagtcct     1500

cttaacatct atatccacct tcattaaagg agacctcacc atagctaatc ttgggacatc     1560

agagggtcgc ttcatgcagg ttgtggtttc tcgatcagga ccatcaaccc ctcatgtgaa     1620

ttttctcctg gactcccatc cagtgtctcc agaagtgatt gtggagcata cattaaacca     1680

aaatggctac acactggtta tcactgggaa gaagatcacg aagatcccat tgaatggctt     1740

gggctgcaga catttccagt cctgcagtca atgcctctct gccccaccct ttgttcagtg     1800

tggctggtgc cacgacaaat gtgtgcgatc ggaggaatgc ctgagcggga catggactca     1860

acagatctgt ctgcctgcaa tctacaaggt tttcccaaat agtgcacccc ttgaaggagg     1920

gacaaggctg accatatgtg gctgggactt tggatttcgg aggaataata aatttgattt     1980

aaagaaaact agagttctcc ttggaaatga gagctgcacc ttgactttaa gtgagagcac     2040

gatgaataca ttgaaatgca cagttggtcc tgccatgaat aagcatttca atatgtccat     2100

aattatttca aatggccacg ggacaacaca atacagtaca ttctcctatg tggatcctgt     2160

aataacaagt atttcgccga aatacggtcc tatggctggt ggcactttac ttactttaac     2220

tggaaattac ctaaacagtg ggaattctag acacatttca attggtggaa aaacatgtac     2280

tttaaaaagt gtgtcaaaca gtattcttga atgttatacc ccagcccaaa ccatttcaac     2340

tgagtttgct gttaaattga aaattgactt agccaaccga gagacaagca tcttcagtta     2400

ccgtgaagat cccattgtct atgaaattca tccaaccaaa tcttttatta gtggtgggag     2460

cacaataaca ggtgttggga aaaacctgaa ttcagttagt gtcccgagaa tggtcataaa     2520

tgtgcatgaa gcaggaagga actttacagt ggcatgtcaa catcgctcta attcagagat     2580

aatctgttgt accactcctt ccctgcaaca gctgaatctg caactccccc tgaaaaccaa     2640

agcctttttc atgttagatg ggatcctttc caaatacttt gatctcattt atgtacataa     2700

tcctgtgttt aagccttttg aaaagccagt gatgatctca atgggcaatg aaaatgtact     2760

ggaaattaag ggaaatgata ttgaccctga agcagttaaa ggtgaagtgt taaaagttgg     2820

aaataagagc tgtgagaata tacacttaca ttctgaagcc gttttatgca cggtccccaa     2880

tgacctgctg aaattgaaca gcgagctaaa tatagagtgg aagcaagcaa tttcttcaac     2940

cgtccttgga aaagtaatag ttcaaccaga tcagaatttc acaggattga ttgctggtgt     3000

tgtctcaata tcaacagcac tgttattact acttgggttt ttcctgtggc tgaaaaagag     3060

aaagcaaatt aaagatctgg gcagtgaatt agttcgctac gatgcaagag tacacactcc     3120

tcatttggat aggcttgtaa gtgcccgaag tgtaagccca actacagaaa tggtttcaaa     3180

tgaatctgta gactaccgag ctacttttcc agaagatcag tttcctaatt catctcagaa     3240

cggttcatgc cgacaagtgc agtatcctct gacagacatg tcccccatcc taactagtgg     3300

ggactctgat atatccagtc cattactgca aaatactgtc cacattgacc tcagtgctct     3360

aaatccagag ctggtccagg cagtgcagca tgtagtgatt gggcccagta gcctgattgt     3420

gcatttcaat gaagtcatag gaagagggca ttttggttgt gtatatcatg ggactttgtt     3480

ggacaatgat ggcaagaaaa ttcactgtgc tgtgaaatcc ttgaacagaa tcactgacat     3540

aggagaagtt tcccaatttc tgaccgaggg aatcatcatg aaagatttta gtcatcccaa     3600

tgtcctctcg ctcctgggaa tctgcctgcg aagtgaaggg tctccgctgg tggtcctacc     3660

atacatgaaa catggagatc ttcgaaattt cattcgaaat gagactcata atccaactgt     3720

aaaagatctt attggctttg gtcttcaagt agccaaaggc atgaaatatc ttgcaagcaa     3780

aaagtttgtc cacagagact tggctgcaag aaactgtatg ctggatgaaa aattcacagt     3840

caaggttgct gattttggtc ttgccagaga catgtatgat aaagaatact atagtgtaca     3900

caacaaaaca ggtgcaaagc tgccagtgaa gtggatggct ttggaaagtc tgcaaactca     3960

aaagtttacc accaagtcag atgtgtggtc ctttggcgtg ctcctctggg agctgatgac     4020

aagaggagcc ccaccttatc ctgacgtaaa cacctttgat ataactgttt acttgttgca     4080

agggagaaga ctcctacaac ccgaatactg cccagacccc ttatatgaag taatgctaaa     4140

atgctggcac cctaaagccg aaatgcgccc atccttttct gaactggtgt cccggatatc     4200

agcgatcttc tctactttca ttggggagca ctatgtccat gtgaacgcta cttatgtgaa     4260

cgtaaaatgt gtcgctccgt atccttctct gttgtcatca gaagataacg ctgatgatga     4320

ggtggacaca cgaccagcct ccttctggga gacatcatag tgctagtact atgtcaaagc     4380

aacagtccac actttgtcca atggtttttt cactgcctga cctttaaaag gccatcgata     4440

ttctttgctc ttgccaaaat tgcactatta taggacttgt attgttattt aaattactgg     4500

attctaagga atttcttatc tgacagagca tcagaaccag aggcttggtc ccacaggcca     4560

cggaccaatg gcctgcagcc gtgacaacac tcctgtcata ttggagtcca aaacttgaat     4620

tctgggttga attttttaaa aatcaggtac cacttgattt catatgggaa attgaagcag     4680

gaaatattga gggcttcttg atcacagaaa actcagaaga gatagtaatg ctcaggacag     4740

gagcggcagc cccagaacag gccactcatt tagaattcta gtgtttcaaa acacttttgt     4800

gtgttgtatg gtcaataaca tttttcatta ctgatggtgt cattcaccca ttaggtaaac     4860

attccctttt aaatgtttgt ttgttttttg agacaggatc tcactctgtt gccagggctg     4920

tagtgcagtg gtgtgatcat agctcactgc aacctccacc tcccaggctc aagcctcccg     4980

aatagctggg actacaggcg cacaccacca tccccggcta atttttgtat tttttgtaga     5040

gacggggttt tgccatgttg ccaaggctgg tttcaaactc ctggactcaa gaaatccacc     5100

cacctcagcc tcccaaagtg ctaggattac aggcatgagc cactgcgccc agcccttata     5160

aatttttgta tagacattcc tttggttgga agaatattta taggcaatac agtcaaagtt     5220

tcaaaatagc atcacacaaa acatgtttat aaatgaacag gatgtaatgt acatagatga     5280

cattaagaaa atttgtatga aataatttag tcatcatgaa atatttagtt gtcatataaa     5340

aacccactgt ttgagaatga tgctactctg atctaatgaa tgtgaacatg tagatgtttt     5400

gtgtgtattt ttttaaatga aaactcaaaa taagacaagt aatttgttga taaatatttt     5460

taaagataac tcagcatgtt tgtaaagcag gatacatttt actaaaaggt tcattggttc     5520

caatcacagc tcataggtag agcaaagaaa gggtggatgg attgaaaaga ttagcctctg     5580

tctcggtggc aggttcccac ctcgcaagca attggaaaca aaacttttgg ggagttttat     5640

tttgcattag ggtgtgtttt atgttaagca aaacatactt tagaaacaaa tgaaaaaggc     5700

aattgaaaat cccagctatt tcacctagat ggaatagcca ccctgagcag aactttgtga     5760

tgcttcattc tgtggaattt tgtgcttgct actgtatagt gcatgtggtg taggttactc     5820

taactggttt tgtcgacgta aacatttaaa gtgttatatt ttttataaaa atgtttattt     5880

ttaatgatat gagaaaaatt ttgttaggcc acaaaaacac tgcactgtga acattttaga     5940

aaaggtatgt cagactggga ttaatgacag catgattttc aatgactgta aattgcgata     6000

aggaaatgta ctgattgcca atacacccca ccctcattac atcatcagga cttgaagcca     6060

agggttaacc cagcaagcta caaagagggt gtgtcacact gaaactcaat agttgagttt     6120

ggctgttgtt gcaggaaaat gattataact aaaagctctc tgatagtgca gagacttacc     6180

agaagacaca aggaattgta ctgaagagct attacaatcc aaatattgcc gtttcataaa     6240

tgtaataagt aatactaatt cacagagtat tgtaaatggt ggatgacaaa agaaaatctg     6300

ctctgtggaa agaaagaact gtctctacca gggtcaagag catgaacgca tcaatagaaa     6360

gaactcgggg aaacatccca tcaacaggac tacacacttg tatatacatt cttgagaaca     6420

ctgcaatgtg aaaatcacgt ttgctattta taaacttgtc cttagattaa tgtgtctgga     6480

cagattgtgg gagtaagtga ttcttctaag aattagatac ttgtcactgc ctatacctgc     6540

agctgaactg aatggtactt cgtatgttaa tagttgttct gataaatcat gcaattaaag     6600

taaagtgatg caacatcttg taaaaaaaaa aaaaaaaaaa a                         6641


<210>  5
<211>  1846
<212>  DNA
<213>  Homo sapiens

<400>  5
aaaagtgcct ttgttggcct gggctcagga atccagagaa actggtcagg aggaggcccc       60

agtgacaaaa acccctccct ctgcccccgc ccctctgcca gagccatata actgctcaac      120

ctgtccccga gagagagtgc cctggcagct gtcggctgga aggaactggt ctgctcacac      180

ttgctggctt gcgcatcagg actggcttta tctcctgact cacggtgcaa aggtgcactc      240

tgcgaacgtt aagtccgtcc ccagcgcttg gaatcctacg gcccccacag ccggatcccc      300

tcagccttcc aggtcctcaa ctcccgtgga cgctgaacaa tggcctccat ggggctacag      360

gtaatgggca tcgcgctggc cgtcctgggc tggctggccg tcatgctgtg ctgcgcgctg      420

cccatgtggc gcgtgacggc cttcatcggc agcaacattg tcacctcgca gaccatctgg      480

gagggcctat ggatgaactg cgtggtgcag agcaccggcc agatgcagtg caaggtgtac      540

gactcgctgc tggcactgcc gcaggacctg caggcggccc gcgccctcgt catcatcagc      600

atcatcgtgg ctgctctggg cgtgctgctg tccgtggtgg ggggcaagtg taccaactgc      660

ctggaggatg aaagcgccaa ggccaagacc atgatcgtgg cgggcgtggt gttcctgttg      720

gccggcctta tggtgatagt gccggtgtcc tggacggccc acaacatcat ccaagacttc      780

tacaatccgc tggtggcctc cgggcagaag cgggagatgg gtgcctcgct ctacgtcggc      840

tgggccgcct ccggcctgct gctccttggc ggggggctgc tttgctgcaa ctgtccaccc      900

cgcacagaca agccttactc cgccaagtat tctgctgccc gctctgctgc tgccagcaac      960

tacgtgtaag gtgccacggc tccactctgt tcctctctgc tttgttcttc cctggactga     1020

gctcagcgca ggctgtgacc ccaggagggc cctgccacgg gccactggct gctggggact     1080

ggggactggg cagagactga gccaggcagg aaggcagcag ccttcagcct ctctggccca     1140

ctcggacaac ttcccaaggc cgcctcctgc tagcaagaac agagtccacc ctcctctgga     1200

tattggggag ggacggaagt gacagggtgt ggtggtggag tggggagctg gcttctgctg     1260

gccaggatag cttaaccctg actttgggat ctgcctgcat cggcgttggc cactgtcccc     1320

atttacattt tccccactct gtctgcctgc atctcctctg ttccgggtag gccttgatat     1380

cacctctggg actgtgcctt gctcaccgaa acccgcgccc aggagtatgg ctgaggcctt     1440

gcccacccac ctgcctggga agtgcagagt ggatggacgg gtttagaggg gaggggcgaa     1500

ggtgctgtaa acaggtttgg gcagtggtgg gggagggggc cagagaggcg gctcaggttg     1560

cccagctctg tggcctcagg actctctgcc tcacccgctt cagcccaggg cccctggaga     1620

ctgatcccct ctgagtcctc tgccccttcc aaggacacta atgagcctgg gagggtggca     1680

gggaggaggg gacagcttca cccttggaag tcctggggtt tttcctcttc cttctttgtg     1740

gtttctgttt tgtaatttaa gaagagctat tcatcactgt aattattatt attttctaca     1800

ataaatggga cctgtgcaca ggaaaaaaaa aaaaaaaaaa aaaaaa                    1846


<210>  6
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Ala Met Asn Gln Arg Ile Ser Gln Ser Ala Pro 
225                 230                 235                 240 


Val Lys Gln Pro Pro Pro Leu Ala Pro Gln Ser Pro Gln Gly Gly Val 
                245                 250                 255     


Met Gly Gly Ser Asn Ser Asn Gln Gln Gln Gln Met Arg Leu Gln Gln 
            260                 265                 270         


Leu Gln Met Glu Lys Glu Arg Leu Arg Leu Lys Gln Gln Glu Leu Leu 
        275                 280                 285             


Arg Gln Val Arg Pro Gln Glu Leu Ala Leu Arg Ser Gln Leu Pro Thr 
    290                 295                 300                 


Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro Gly Met 
305                 310                 315                 320 


Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro Phe Leu 
                325                 330                 335     


Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp Ser Gly Leu 
            340                 345                 350         


Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe Leu Asn 
        355                 360                 365             


Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser Thr Leu 
    370                 375                 380                 


Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile Pro Gly 
385                 390                 395                 400 


Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn Ile Glu 
                405                 410                 415     


Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser Asp Ile 
            420                 425                 430         


Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp Lys Glu 
        435                 440                 445             


Ser Phe Leu Thr Trp Leu 
    450                 


<210>  7
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Thr Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Arg Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  8
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe 
            20                  25                  30          


Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala 
        35                  40                  45              


Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser 
    50                  55                  60                  


Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met 
65                  70                  75                  80  


Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln 
                85                  90                  95      


Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala 
            100                 105                 110         


His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys 
        115                 120                 125             


Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe 
    130                 135                 140                 


Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr 
145                 150                 155                 160 


Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr 
                165                 170                 175     


Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu 
            180                 185                 190         


Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser 
        195                 200                 205             


Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile 
    210                 215                 220                 


Ile Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn 
225                 230                 235                 240 


Lys Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys 
                245                 250                 255     


Leu Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser 
            260                 265                 270         


Thr Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu 
        275                 280                 285             


Glu Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys 
    290                 295                 300                 


Gly Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys 
305                 310                 315                 320 


Asn Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu 
                325                 330                 335     


Asn Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro 
            340                 345                 350         


Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys 
        355                 360                 365             


Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr 
    370                 375                 380                 


Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser 
385                 390                 395                 400 


Tyr Ser Glu Glu Val Cys Arg Cys Val Pro Ser Tyr Trp Lys Arg Pro 
                405                 410                 415     


Gln Met Ser 
            


<210>  9
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  10
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ser Met Gly Leu Gln Val Met Gly Ile Ala Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Ala Val Met Leu Cys Cys Ala Leu Pro Met Trp Arg Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Ser Asn Ile Val Thr Ser Gln Thr Ile Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Val Ile Ile Ser Ile Ile Val Ala Ala Leu Gly Val Leu 
                85                  90                  95      


Leu Ser Val Val Gly Gly Lys Cys Thr Asn Cys Leu Glu Asp Glu Ser 
            100                 105                 110         


Ala Lys Ala Lys Thr Met Ile Val Ala Gly Val Val Phe Leu Leu Ala 
        115                 120                 125             


Gly Leu Met Val Ile Val Pro Val Ser Trp Thr Ala His Asn Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Ser Gly Gln Lys Arg Glu Met 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Val Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Asn Cys Pro Pro Arg Thr Asp Lys Pro 
            180                 185                 190         


Tyr Ser Ala Lys Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser Asn Tyr 
        195                 200                 205             


Val 
    


<210>  11
<211>  472
<212>  DNA
<213>  Homo sapiens

<400>  11
ttttttgtgg caataattaa tatatttata tggaaattgt ctcatgcctt ataagctcct       60

aaaataaaat caaggtcatt atgtgactaa tgatagcact aggaggaaaa gaaaatactg      120

aaagtaaaac agtcttcagc cttggtttca gctatctctt caaatcagca ttaagtattt      180

aatatcagat ataacatttt tggcttgtca gaccagtaaa tcatgttttt ccactggaca      240

aaggaagctg aagaaacaac tgttgaacaa actaaatgct gtgacatgaa gcatctgact      300

tctaagtctg agtatttagt taaaatgatt ggtgaacatt taactgggca aaaggaatgg      360

catccatcat ccaaacaggc tcacttcccc cagcccccaa aatgaacagt agttttagat      420

agcaaagaaa taaaaagttt ttttcttttg attgtttaga gccaactgtg aa              472


<210>  12
<211>  504
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (468)..(468)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (491)..(491)
<223>  n is a, c, g, or t

<400>  12
tttcaaactc ctggactcaa gaaatccacc cacctcagcc tcccaaagtg ctaggattac       60

aggcatgagc cactgcgccc agcccttata aatttttgta tagacattcc tttggttgga      120

agaatattta taggcaatac agtcaaagtt tcaaaatagc atcacacaaa acatgtttat      180

aaatgaacag gatgtaatgt acatagatga cattaagaaa atttgtatga aataatttag      240

tcatcatgaa atatttagtt gtcatataaa aacccactgt ttgagaatga tgctactctg      300

atctaatgaa tgtgaacatg tagatgtttt gtgtgtattt ttttaaatga aaactcaaaa      360

taagacaagt aatttgttga taaatatttt taaagataac tcagcatgtt tgtaaagcag      420

gataccattt tacctaaaag gttcattggt tccaatccac agctcatngg tagagcaagg      480

aaggggtgga nggatggaaa ggat                                             504


<210>  13
<211>  242
<212>  DNA
<213>  Homo sapiens

<400>  13
tttttcctgt gcacaggtcc catttattgt agaaaataat aataattaca gtgatgaata       60

gctcttctta aattacaaaa cagaaaccac aaagaaggaa gaggaaaaac cccaggactt      120

ccaagggtga agctgtcccc tcctccctgc caccctccca ggctcattag tgtccttgga      180

aggggcagag gactcagagg ggatcagtct ccaggggccc tgggctgaag cgggtgaggc      240

ag                                                                     242


