                         SEQUENCE LISTING

<110>  Wyeth
       DODGE, Ingrid
       ROJAS, Eduardo
       ANDERSON, Annaliesa
       HAGEN, Michael
       SINGH, Guy
 
<120>  Multicomponent Immunogenic Composition for the Prevention of 
       Beta-Hemolytic Streptococcal (BHS) Disease

<130>  AM103175 

<160>  10    

<170>  PatentIn version 3.2

<210>  1
<211>  3505
<212>  DNA
<213>  Streptococcus pyogenes

<400>  1
ttgcgtaaaa aacaaaaatt accatttgat aaacttgcca ttgcgctcat gtctacgagc     60

atcttgctca atgcacaatc agacattaaa gcaaatactg tgacagaaga cactcctgct    120

accgaacaag ctgtagaaac cccacaacca acagcggttt ctgaggaagc accatcatca    180

aaggaaacca aaaccccaca aactcctgat gacgcagaag aaacaatagc agatgacgct    240

aatgatctag cccctcaagc tcctgctaaa actgctgata caccagcaac ctcaaaagcg    300

actattaggg atttgaacga cccttctcag gtcaaaaccc tgcaggaaaa agcaggcaaa    360

ggagctggga ctgttgttgc agtgattgat gctggttttg ataaaaatca tgaagcgtgg    420

cgcttaacag acaaaaccaa agcacgttac caatcaaaag aagatcttga aaaagctaaa    480

aaagagcacg gtattaccta tggcgagtgg gtcaatgata aggttgctta ttaccacgac    540

tatagtaaag atggtaaaac cgctgtcgat caagagcacg gcacacacgt gtcagggatc    600

ttgtcaggaa atgctccatc tgaaacgaaa gaaccttacc gcctagaagg tgcgatgcct    660

gaggctcaat tgcttttgat gcgtgtcgaa attgtaaatg gactagcaga ctatgctcgt    720

aactacgctc aagctatcat agatgctgtc aacttgggag ctaaggtgat taatatgagc    780

tttggtaatg ctgcactagc ctatgccaac cttccagacg aaaccaaaaa agcctttgac    840

tatgccaaat caaaaggtgt tagcattgtg acctcagctg gtaatgatag tagctttggg    900

ggcaagaccc gtctacctct agcagatcat cctgattatg gggtggttgg gacacctgca    960

gcggcagact caacattgac agttgcttct tacagcccag ataaacagct cactgaaact   1020

gctacggtca aaacagccga tcagcaagat aaagaaatgc ctgttctttc aacaaaccgt   1080

tttgagccaa acaaggctta cgactatgct tatgctaatc gtgggatgaa agaggatgat   1140

tttaaggatg tcaaaggtaa gattgccctt attgaacgtg gcgatattga tttcaaagat   1200

aagattgcaa acgctaaaaa agctggtgct gtaggagtct tgatctatga caatcaggac   1260

aagggcttcc cgattgaatt gccaaatgtt gatcagatgc ctgcggcctt tatcagtcga   1320

aaagatggtc tcttattaaa agagaatccc caaaaaacca tcaccttcaa tgcgacacct   1380

aaggtattgc caacagcaag tggcaccaaa ctaagccgct tctcaagctg gggtctgaca   1440

gctgacggca atattaagcc agatattgca gcacccggcc aagatatttt gtcatcagtg   1500

gctaacaaca agtatgccaa actttctgga actagtatgt ctgcgccatt agtagcgggt   1560

atcatgggac tgttgcaaaa gcaatatgag acacagtatc ctgatatgac accatcagag   1620

cgtcttgatt tagctaaaaa agtattgatg agctcagcaa ctgccttata tgatgaagat   1680

gaaaaagctt atttttctcc tcgccaacaa ggagcaggag cagtcgatgc taaaaaagct   1740

tcagcagcaa cgatgtatgt gacagataag gataatacct caagcaaggt tcacctgaac   1800

aatgtttctg ataaatttga agtaacagta acagttcaca acaaatctga taaacctcaa   1860

gagttgtatt accaagcaac tgttcaaaca gataaagtag atggaaaact ctttgccttg   1920

gctcctaaag cattgtatga gacatcatgg caaaaaatca caattccagc caatagcagc   1980

aaacaagtca ccattccaat cgatgttagt caatttagca aggacttgct tgccccaatg   2040

aaaaatggct atttcttaga aggttttgtt cgtttcaaac aagatcctac aaaagaagag   2100

cttatgagta ttccctatat tggtttccga ggtgattttg gcaatctgtc agccttagaa   2160

aaaccaatct atgatagcaa agacggtagc agctactatc atgaagcaaa tagtgatgcc   2220

aaagaccaat tagatggtga tggattacag ttttacgctc tgaaaaataa ctttacagca   2280

cttactacag agtctaatcc atggacgatt attaaagctg tcaaagaagg ggttgaaaac   2340

atagaggata tcgaatcttc agagatcaca gaaaccattt ttgcaggtac ttttgcaaaa   2400

caagacgatg atagccacta ctatatccac cgtcacgcta atggcaagcc atatgctgcg   2460

atctctccaa atggggacgg taacagagat tatgtccaat tccaaggtac tttcttgcgt   2520

aatgctaaaa accttgtggc tgaagtcttg gacaaagaag gaaatgttgt ttggacaagt   2580

gaggtaaccg agcaagttgt taaaaactac aacaatgact tggcaagcac acttggttca   2640

acccgttttg aaaaaacgcg ttgggacggt aaagataaag acggcaaagt tgttgctaac   2700

ggaacataca cctatcgtgt tcgctacact ccgattagct caggtgcaaa agaacaacac   2760

actgattttg atgtgattgt agacaatacg acacctgaag tcgcaacatc ggcaacattc   2820

tcaacagaag atcgtcgttt gacacttgca tctaaaccaa aaaccagcca accggtttac   2880

cgtgagcgta ttgcttacac ttatatggat gaggatctgc caacaacaga gtatatttct   2940

ccaaatgaag atggtacctt tactcttcct gaagaggctg aaacaatgga aggcgctact   3000

gttccattga aaatgtcaga ctttacttat gttgttgaag atatggctgg taacatcact   3060

tatacaccag tgactaagct attggaaggc cactctaata aaccagaaca agacggttca   3120

gatcaagcac cagacaaaaa accagaaact aaaccagaac aagacggttc aggtcaagca   3180

ccagataaaa aaccagaaac taaaccagaa caagacggtt caggtcaaac accagacaaa   3240

aaaccagaaa ctaaaccaga acaagacggt tcaggtcaaa caccagataa aaaaccagaa   3300

actaaaccag aaaaagatag ttcaggtcaa acaccaggta aaactcctca aaaaggtcaa   3360

ccttctcgta ctctagagaa acgatcttct aagcgtgctt tagctacaaa agcatcaaca   3420

aaagatcagt taccaacgac taatgacaag gatacaaatc gtttacatct ccttaagtta   3480

gttatgacca ctttcttctt gggat                                         3505


<210>  2
<211>  1181
<212>  PRT
<213>  Streptococcus pyogenes

<400>  2

Leu Arg Lys Lys Gln Lys Leu Pro Phe Asp Lys Leu Ala Ile Ala Leu 
1               5                   10                  15      


Met Ser Thr Ser Ile Leu Leu Asn Ala Gln Ser Asp Ile Lys Ala Asn 
            20                  25                  30          


Thr Val Thr Glu Asp Thr Pro Ala Thr Glu Gln Ala Val Glu Thr Pro 
        35                  40                  45              


Gln Pro Thr Ala Val Ser Glu Glu Ala Pro Ser Ser Lys Glu Thr Lys 
    50                  55                  60                  


Thr Pro Gln Thr Pro Asp Asp Ala Glu Glu Thr Ile Ala Asp Asp Ala 
65                  70                  75                  80  


Asn Asp Leu Ala Pro Gln Ala Pro Ala Lys Thr Ala Asp Thr Pro Ala 
                85                  90                  95      


Thr Ser Lys Ala Thr Ile Arg Asp Leu Asn Asp Pro Ser Gln Val Lys 
            100                 105                 110         


Thr Leu Gln Glu Lys Ala Gly Lys Gly Ala Gly Thr Val Val Ala Val 
        115                 120                 125             


Ile Asp Ala Gly Phe Asp Lys Asn His Glu Ala Trp Arg Leu Thr Asp 
    130                 135                 140                 


Lys Thr Lys Ala Arg Tyr Gln Ser Lys Glu Asp Leu Glu Lys Ala Lys 
145                 150                 155                 160 


Lys Glu His Gly Ile Thr Tyr Gly Glu Trp Val Asn Asp Lys Val Ala 
                165                 170                 175     


Tyr Tyr His Asp Tyr Ser Lys Asp Gly Lys Thr Ala Val Asp Gln Glu 
            180                 185                 190         


His Gly Thr His Val Ser Gly Ile Leu Ser Gly Asn Ala Pro Ser Glu 
        195                 200                 205             


Thr Lys Glu Pro Tyr Arg Leu Glu Gly Ala Met Pro Glu Ala Gln Leu 
    210                 215                 220                 


Leu Leu Met Arg Val Glu Ile Val Asn Gly Leu Ala Asp Tyr Ala Arg 
225                 230                 235                 240 


Asn Tyr Ala Gln Ala Ile Ile Asp Ala Val Asn Leu Gly Ala Lys Val 
                245                 250                 255     


Ile Asn Met Ser Phe Gly Asn Ala Ala Leu Ala Tyr Ala Asn Leu Pro 
            260                 265                 270         


Asp Glu Thr Lys Lys Ala Phe Asp Tyr Ala Lys Ser Lys Gly Val Ser 
        275                 280                 285             


Ile Val Thr Ser Ala Gly Asn Asp Ser Ser Phe Gly Gly Lys Thr Arg 
    290                 295                 300                 


Leu Pro Leu Ala Asp His Pro Asp Tyr Gly Val Val Gly Thr Pro Ala 
305                 310                 315                 320 


Ala Ala Asp Ser Thr Leu Thr Val Ala Ser Tyr Ser Pro Asp Lys Gln 
                325                 330                 335     


Leu Thr Glu Thr Ala Thr Val Lys Thr Ala Asp Gln Gln Asp Lys Glu 
            340                 345                 350         


Met Pro Val Leu Ser Thr Asn Arg Phe Glu Pro Asn Lys Ala Tyr Asp 
        355                 360                 365             


Tyr Ala Tyr Ala Asn Arg Gly Met Lys Glu Asp Asp Phe Lys Asp Val 
    370                 375                 380                 


Lys Gly Lys Ile Ala Leu Ile Glu Arg Gly Asp Ile Asp Phe Lys Asp 
385                 390                 395                 400 


Lys Ile Ala Asn Ala Lys Lys Ala Gly Ala Val Gly Val Leu Ile Tyr 
                405                 410                 415     


Asp Asn Gln Asp Lys Gly Phe Pro Ile Glu Leu Pro Asn Val Asp Gln 
            420                 425                 430         


Met Pro Ala Ala Phe Ile Ser Arg Lys Asp Gly Leu Leu Leu Lys Glu 
        435                 440                 445             


Asn Pro Gln Lys Thr Ile Thr Phe Asn Ala Thr Pro Lys Val Leu Pro 
    450                 455                 460                 


Thr Ala Ser Gly Thr Lys Leu Ser Arg Phe Ser Ser Trp Gly Leu Thr 
465                 470                 475                 480 


Ala Asp Gly Asn Ile Lys Pro Asp Ile Ala Ala Pro Gly Gln Asp Ile 
                485                 490                 495     


Leu Ser Ser Val Ala Asn Asn Lys Tyr Ala Lys Leu Ser Gly Thr Ser 
            500                 505                 510         


Met Ser Ala Pro Leu Val Ala Gly Ile Met Gly Leu Leu Gln Lys Gln 
        515                 520                 525             


Tyr Glu Thr Gln Tyr Pro Asp Met Thr Pro Ser Glu Arg Leu Asp Leu 
    530                 535                 540                 


Ala Lys Lys Val Leu Met Ser Ser Ala Thr Ala Leu Tyr Asp Glu Asp 
545                 550                 555                 560 


Glu Lys Ala Tyr Phe Ser Pro Arg Gln Gln Gly Ala Gly Ala Val Asp 
                565                 570                 575     


Ala Lys Lys Ala Ser Ala Ala Thr Met Tyr Val Thr Asp Lys Asp Asn 
            580                 585                 590         


Thr Ser Ser Lys Val His Leu Asn Asn Val Ser Asp Lys Phe Glu Val 
        595                 600                 605             


Thr Val Thr Val His Asn Lys Ser Asp Lys Pro Gln Glu Leu Tyr Tyr 
    610                 615                 620                 


Gln Ala Thr Val Gln Thr Asp Lys Val Asp Gly Lys Leu Phe Ala Leu 
625                 630                 635                 640 


Ala Pro Lys Ala Leu Tyr Glu Thr Ser Trp Gln Lys Ile Thr Ile Pro 
                645                 650                 655     


Ala Asn Ser Ser Lys Gln Val Thr Ile Pro Ile Asp Val Ser Gln Phe 
            660                 665                 670         


Ser Lys Asp Leu Leu Ala Pro Met Lys Asn Gly Tyr Phe Leu Glu Gly 
        675                 680                 685             


Phe Val Arg Phe Lys Gln Asp Pro Thr Lys Glu Glu Leu Met Ser Ile 
    690                 695                 700                 


Pro Tyr Ile Gly Phe Arg Gly Asp Phe Gly Asn Leu Ser Ala Leu Glu 
705                 710                 715                 720 


Lys Pro Ile Tyr Asp Ser Lys Asp Gly Ser Ser Tyr Tyr His Glu Ala 
                725                 730                 735     


Asn Ser Asp Ala Lys Asp Gln Leu Asp Gly Asp Gly Leu Gln Phe Tyr 
            740                 745                 750         


Ala Leu Lys Asn Asn Phe Thr Ala Leu Thr Thr Glu Ser Asn Pro Trp 
        755                 760                 765             


Thr Ile Ile Lys Ala Val Lys Glu Gly Val Glu Asn Ile Glu Asp Ile 
    770                 775                 780                 


Glu Ser Ser Glu Ile Thr Glu Thr Ile Phe Ala Gly Thr Phe Ala Lys 
785                 790                 795                 800 


Gln Asp Asp Asp Ser His Tyr Tyr Ile His Arg His Ala Asn Gly Lys 
                805                 810                 815     


Pro Tyr Ala Ala Ile Ser Pro Asn Gly Asp Gly Asn Arg Asp Tyr Val 
            820                 825                 830         


Gln Phe Gln Gly Thr Phe Leu Arg Asn Ala Lys Asn Leu Val Ala Glu 
        835                 840                 845             


Val Leu Asp Lys Glu Gly Asn Val Val Trp Thr Ser Glu Val Thr Glu 
    850                 855                 860                 


Gln Val Val Lys Asn Tyr Asn Asn Asp Leu Ala Ser Thr Leu Gly Ser 
865                 870                 875                 880 


Thr Arg Phe Glu Lys Thr Arg Trp Asp Gly Lys Asp Lys Asp Gly Lys 
                885                 890                 895     


Val Val Ala Asn Gly Thr Tyr Thr Tyr Arg Val Arg Tyr Thr Pro Ile 
            900                 905                 910         


Ser Ser Gly Ala Lys Glu Gln His Thr Asp Phe Asp Val Ile Val Asp 
        915                 920                 925             


Asn Thr Thr Pro Glu Val Ala Thr Ser Ala Thr Phe Ser Thr Glu Asp 
    930                 935                 940                 


Arg Arg Leu Thr Leu Ala Ser Lys Pro Lys Thr Ser Gln Pro Val Tyr 
945                 950                 955                 960 


Arg Glu Arg Ile Ala Tyr Thr Tyr Met Asp Glu Asp Leu Pro Thr Thr 
                965                 970                 975     


Glu Tyr Ile Ser Pro Asn Glu Asp Gly Thr Phe Thr Leu Pro Glu Glu 
            980                 985                 990         


Ala Glu Thr Met Glu Gly Ala Thr  Val Pro Leu Lys Met  Ser Asp Phe 
        995                 1000                 1005             


Thr Tyr  Val Val Glu Asp Met  Ala Gly Asn Ile Thr  Tyr Thr Pro 
    1010                 1015                 1020             


Val Thr  Lys Leu Leu Glu Gly  His Ser Asn Lys Pro  Glu Gln Asp 
    1025                 1030                 1035             


Gly Ser  Asp Gln Ala Pro Asp  Lys Lys Pro Glu Thr  Lys Pro Glu 
    1040                 1045                 1050             


Gln Asp  Gly Ser Gly Gln Ala  Pro Asp Lys Lys Pro  Glu Thr Lys 
    1055                 1060                 1065             


Pro Glu  Gln Asp Gly Ser Gly  Gln Thr Pro Asp Lys  Lys Pro Glu 
    1070                 1075                 1080             


Thr Lys  Pro Glu Gln Asp Gly  Ser Gly Gln Thr Pro  Asp Lys Lys 
    1085                 1090                 1095             


Pro Glu  Thr Lys Pro Glu Lys  Asp Ser Ser Gly Gln  Thr Pro Gly 
    1100                 1105                 1110             


Lys Thr  Pro Gln Lys Gly Gln  Pro Ser Arg Thr Leu  Glu Lys Arg 
    1115                 1120                 1125             


Ser Ser  Lys Arg Ala Leu Ala  Thr Lys Ala Ser Thr  Lys Asp Gln 
    1130                 1135                 1140             


Leu Pro  Thr Thr Asn Asp Lys  Asp Thr Asn Arg Leu  His Leu Leu 
    1145                 1150                 1155             


Lys Leu  Val Met Thr Thr Phe  Phe Leu Gly Leu Val  Ala His Ile 
    1160                 1165                 1170             


Phe Lys  Thr Lys Arg Thr Glu  Asp 
    1175                 1180     


<210>  3
<211>  1056
<212>  DNA
<213>  Streptococcus pyogenes

<400>  3
atgaaaaact caaataaact cattgctagt gttgtgacat tggcctcagt gatggcttta     60

gcagcttgtc aatcaactaa tgacaatact aaggttattt cgatgaaagg tgatacaatt    120

agcgttagtg atttttacaa tgaaacaaaa aacacagaag tatcgcaaaa agcgatgcta    180

aatctggtaa ttagtcgtgt ttttgaagct caatatggtg ataaggtttc aaaaaaagaa    240

gttgaaaagg cgtatcataa aacagctgaa cagtatggcg cttcattctc tgctgctttg    300

gcacaatcaa gcttgacacc tgagactttt aagcgtcaga tccgctcttc aaaattagta    360

gaatatgcgg ttaaagaagc agctaaaaaa gaattgacaa cacaagaata taagaaagca    420

tatgaatctt atactccaac aatggcagtc gaaatgatta ctttagataa tgaagagaca    480

gctaaatcag tcttagagga actaaaagcc gaaggcgcag actttacagc tattgctaaa    540

gaaaaaacaa caacacctga gaaaaaagtg acctataaat ttgattcagg tgcgacaaat    600

gtaccgactg atgtcgtaaa agcggcttca agtttgaatg agggtggcat atcagacgtt    660

atctcggttt tagatccaac ttcttatcaa aagaagtttt acattgttaa ggtgactaaa    720

aaagcagaaa aaaaatcaga ttggcaagaa tataagaaac gtttgaaagc tatcattata    780

gctgaaaaat caaaagatat gaatttccaa aacaaggtta ttgcaaatgc attggataaa    840

gctaatgtaa aaattaaaga caaagctttt gctaatattt tggcgcaata tgcaaatctt    900

ggtcaaaaaa ctaaagctgc aagtgaaagt tcaacaacca gcgaatcatc aaaagctgca    960

gaagagaacc catcagaatc agagcaaaca cagacatcat cagctgaaga accaactgag   1020

actgaggctc agacgcaaga gccagctgca caataa                             1056


<210>  4
<211>  351
<212>  PRT
<213>  Streptococcus pyogenes

<400>  4

Met Lys Asn Ser Asn Lys Leu Ile Ala Ser Val Val Thr Leu Ala Ser 
1               5                   10                  15      


Val Met Ala Leu Ala Ala Cys Gln Ser Thr Asn Asp Asn Thr Lys Val 
            20                  25                  30          


Ile Ser Met Lys Gly Asp Thr Ile Ser Val Ser Asp Phe Tyr Asn Glu 
        35                  40                  45              


Thr Lys Asn Thr Glu Val Ser Gln Lys Ala Met Leu Asn Leu Val Ile 
    50                  55                  60                  


Ser Arg Val Phe Glu Ala Gln Tyr Gly Asp Lys Val Ser Lys Lys Glu 
65                  70                  75                  80  


Val Glu Lys Ala Tyr His Lys Thr Ala Glu Gln Tyr Gly Ala Ser Phe 
                85                  90                  95      


Ser Ala Ala Leu Ala Gln Ser Ser Leu Thr Pro Glu Thr Phe Lys Arg 
            100                 105                 110         


Gln Ile Arg Ser Ser Lys Leu Val Glu Tyr Ala Val Lys Glu Ala Ala 
        115                 120                 125             


Lys Lys Glu Leu Thr Thr Gln Glu Tyr Lys Lys Ala Tyr Glu Ser Tyr 
    130                 135                 140                 


Thr Pro Thr Met Ala Val Glu Met Ile Thr Leu Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Ala Lys Ser Val Leu Glu Glu Leu Lys Ala Glu Gly Ala Asp Phe Thr 
                165                 170                 175     


Ala Ile Ala Lys Glu Lys Thr Thr Thr Pro Glu Lys Lys Val Thr Tyr 
            180                 185                 190         


Lys Phe Asp Ser Gly Ala Thr Asn Val Pro Thr Asp Val Val Lys Ala 
        195                 200                 205             


Ala Ser Ser Leu Asn Glu Gly Gly Ile Ser Asp Val Ile Ser Val Leu 
    210                 215                 220                 


Asp Pro Thr Ser Tyr Gln Lys Lys Phe Tyr Ile Val Lys Val Thr Lys 
225                 230                 235                 240 


Lys Ala Glu Lys Lys Ser Asp Trp Gln Glu Tyr Lys Lys Arg Leu Lys 
                245                 250                 255     


Ala Ile Ile Ile Ala Glu Lys Ser Lys Asp Met Asn Phe Gln Asn Lys 
            260                 265                 270         


Val Ile Ala Asn Ala Leu Asp Lys Ala Asn Val Lys Ile Lys Asp Lys 
        275                 280                 285             


Ala Phe Ala Asn Ile Leu Ala Gln Tyr Ala Asn Leu Gly Gln Lys Thr 
    290                 295                 300                 


Lys Ala Ala Ser Glu Ser Ser Thr Thr Ser Glu Ser Ser Lys Ala Ala 
305                 310                 315                 320 


Glu Glu Asn Pro Ser Glu Ser Glu Gln Thr Gln Thr Ser Ser Ala Glu 
                325                 330                 335     


Glu Pro Thr Glu Thr Glu Ala Gln Thr Gln Glu Pro Ala Ala Gln 
            340                 345                 350     


<210>  5
<211>  3027
<212>  DNA
<213>  Streptococcus pyogenes

<400>  5
atgaagaaac atcttaaaac agttgccttg accctcacta cagtatcggt agtcacccac     60

aatcaggaag tttttagttt agtcaaagag ccaattctta aacaaactca agcttcttca    120

tcgatttctg gcgctgacta cgcagaaagt agcggtaaaa gcaagttaaa gattaatgaa    180

acttctggcc ctgttgatga tacagtcact gacttatttt cggataaacg tactactcct    240

gaaaaaataa aagataatct tgctaaaggt ccgagagaac aagagttaaa ggcagtaaca    300

gagaatacag aatcagaaaa gcagatcact tctggatctc aactagaaca atcaaaagag    360

tctctttctt taaataaaac agtgccatca acgtctaatt gggagatttg tgattttatt    420

actaagggga atacccttgt tggtctttca aaatcaggtg ttgaaaagtt atctcaaact    480

gatcatctcg tattgcctag tcaagcagca gatggaactc aattgataca agtagctagt    540

tttgctttta ctccagataa aaagacggca attgcagaat ataccagtag ggctggagaa    600

aatggggaaa taagccaact agatgtggat ggaaaagaaa ttattaacga aggtgaggtt    660

tttaattctt atctactaaa gaaggtaaca atcccaactg gttataaaca tattggtcaa    720

gatgcttttg tggacaataa gaatattgct gaggttaatc ttcctgaaag cctcgagact    780

atttctgact atgcttttgc tcacctagct ttgaaacaga tcgatttgcc agataattta    840

aaagcgattg gagaattagc tttttttgat aatcaaatta caggtaaact ttctttgcca    900

cgtcagttaa tgcgattagc agaacgtgct tttaaatcaa accatatcaa aacaattgag    960

tttagaggaa atagtctaaa agtgataggg gaagctagtt ttcaagataa tgatctgagt   1020

caactaatgc tacctgacgg tcttgaaaaa atagaatcag aagcttttac aggaaatcca   1080

ggagatgatc actacaataa ccgtgttgtt ttgtggacaa aatctggaaa aaatccttct   1140

ggtcttgcta ctgaaaatac ctatgttaat cctgataagt cactatggca ggaaagtcct   1200

gagattgatt atactaaatg gttagaggaa gattttacct atcaaaaaaa tagtgttaca   1260

ggtttttcaa ataaaggctt acaaaaagta aaacgtaata aaaacttaga aattccaaaa   1320

cagcacaatg gtgttactat tactgaaatt ggtgataatg cttttcgcaa tgttgatttt   1380

caaaataaaa ctttacgtaa atatgatttg gaagaagtaa agcttccctc aactattcgg   1440

aaaataggtg cttttgcttt tcaatctaat aacttgaaat cttttgaagc aagtgacgat   1500

ttagaagaga ttaaagaggg agcctttatg aataatcgta ttgaaacctt ggaattaaaa   1560

gataaattag ttactattgg tgatgcggct ttccatatta atcatattta tgccattgtt   1620

cttccagaat ctgtacaaga aatagggcgt tcagcatttc ggcaaaatgg tgcaaataat   1680

cttattttta tgggaagtaa ggttaagacc ttaggtgaga tggcattttt atcaaataga   1740

cttgaacatc tggatctttc tgagcaaaaa cagttaacag agattcctgt tcaagccttt   1800

tcagacaatg ccttgaaaga agtattatta ccagcatcac tgaaaacgat tcgagaagaa   1860

gccttcaaaa agaatcattt aaaacaactg gaagtggcat ctgccttgtc ccatattgct   1920

tttaatgctt tagatgataa tgatggtgat gaacaatttg ataataaagt ggttgttaaa   1980

acgcatcata attcctacgc actagcagat ggtgagcatt ttatcgttga tccagataag   2040

ttatcttcta caatagtaga ccttgaaaag attttaaaac taatcgaagg tttagattat   2100

tctacattac gtcagactac tcaaactcag tttagagaca tgactactgc aggtaaagcg   2160

ttgttgtcaa aatctaacct ccgacaagga gaaaaacaaa aattccttca agaagcacaa   2220

tttttccttg gccgcgttga tttggataaa gccatagcta aagctgagaa ggctttagtg   2280

accaagaagg caacaaagaa tggtcagttg cttgaaagaa gtattaacaa agcggtatta   2340

gcttataata atagcgctat taaaaaagct aatgttaagc gcttggaaaa agagttagac   2400

ttgctaacag gattagttga gggaaaagga ccattagcgc aagctacaat ggtacaagga   2460

gtttatttat taaagacgcc tttgccattg ccagaatatt atatcggatt gaacgtttat   2520

tttgacaagt ctggaaaatt gatttatgca cttgatatga gtgatactat tggcgaggga   2580

caaaaagacg cttatggtaa tcctatatta aatgttgacg aggataatga aggttatcat   2640

gccttggcag ttgccacttt agctgattat gaggggctcg acatcaaaac aattttaaat   2700

agtaagctta gtcaattaac atctattcgt caggtaccga ctgcagccta tcatagagcc   2760

ggtattttcc aagctatcca aaatgcagcg gcagaagcag agcagttatt gcctaaacca   2820

ggtacgcact ctgagaagtc aagctcaagt gaatctgcta actctaaaga tagaggattg   2880

caatcaaacc caaaaacgaa tagaggacga cactctgcaa tattgcctag gacagggtca   2940

aaaggcagct ttgtctatgg aatcttaggt tacactagcg ttgctttact gtcactaata   3000

actgctataa aaaagaaaaa atattaa                                       3027


<210>  6
<211>  1008
<212>  PRT
<213>  Streptococcus pyogenes

<400>  6

Met Lys Lys His Leu Lys Thr Val Ala Leu Thr Leu Thr Thr Val Ser 
1               5                   10                  15      


Val Val Thr His Asn Gln Glu Val Phe Ser Leu Val Lys Glu Pro Ile 
            20                  25                  30          


Leu Lys Gln Thr Gln Ala Ser Ser Ser Ile Ser Gly Ala Asp Tyr Ala 
        35                  40                  45              


Glu Ser Ser Gly Lys Ser Lys Leu Lys Ile Asn Glu Thr Ser Gly Pro 
    50                  55                  60                  


Val Asp Asp Thr Val Thr Asp Leu Phe Ser Asp Lys Arg Thr Thr Pro 
65                  70                  75                  80  


Glu Lys Ile Lys Asp Asn Leu Ala Lys Gly Pro Arg Glu Gln Glu Leu 
                85                  90                  95      


Lys Ala Val Thr Glu Asn Thr Glu Ser Glu Lys Gln Ile Thr Ser Gly 
            100                 105                 110         


Ser Gln Leu Glu Gln Ser Lys Glu Ser Leu Ser Leu Asn Lys Thr Val 
        115                 120                 125             


Pro Ser Thr Ser Asn Trp Glu Ile Cys Asp Phe Ile Thr Lys Gly Asn 
    130                 135                 140                 


Thr Leu Val Gly Leu Ser Lys Ser Gly Val Glu Lys Leu Ser Gln Thr 
145                 150                 155                 160 


Asp His Leu Val Leu Pro Ser Gln Ala Ala Asp Gly Thr Gln Leu Ile 
                165                 170                 175     


Gln Val Ala Ser Phe Ala Phe Thr Pro Asp Lys Lys Thr Ala Ile Ala 
            180                 185                 190         


Glu Tyr Thr Ser Arg Ala Gly Glu Asn Gly Glu Ile Ser Gln Leu Asp 
        195                 200                 205             


Val Asp Gly Lys Glu Ile Ile Asn Glu Gly Glu Val Phe Asn Ser Tyr 
    210                 215                 220                 


Leu Leu Lys Lys Val Thr Ile Pro Thr Gly Tyr Lys His Ile Gly Gln 
225                 230                 235                 240 


Asp Ala Phe Val Asp Asn Lys Asn Ile Ala Glu Val Asn Leu Pro Glu 
                245                 250                 255     


Ser Leu Glu Thr Ile Ser Asp Tyr Ala Phe Ala His Leu Ala Leu Lys 
            260                 265                 270         


Gln Ile Asp Leu Pro Asp Asn Leu Lys Ala Ile Gly Glu Leu Ala Phe 
        275                 280                 285             


Phe Asp Asn Gln Ile Thr Gly Lys Leu Ser Leu Pro Arg Gln Leu Met 
    290                 295                 300                 


Arg Leu Ala Glu Arg Ala Phe Lys Ser Asn His Ile Lys Thr Ile Glu 
305                 310                 315                 320 


Phe Arg Gly Asn Ser Leu Lys Val Ile Gly Glu Ala Ser Phe Gln Asp 
                325                 330                 335     


Asn Asp Leu Ser Gln Leu Met Leu Pro Asp Gly Leu Glu Lys Ile Glu 
            340                 345                 350         


Ser Glu Ala Phe Thr Gly Asn Pro Gly Asp Asp His Tyr Asn Asn Arg 
        355                 360                 365             


Val Val Leu Trp Thr Lys Ser Gly Lys Asn Pro Ser Gly Leu Ala Thr 
    370                 375                 380                 


Glu Asn Thr Tyr Val Asn Pro Asp Lys Ser Leu Trp Gln Glu Ser Pro 
385                 390                 395                 400 


Glu Ile Asp Tyr Thr Lys Trp Leu Glu Glu Asp Phe Thr Tyr Gln Lys 
                405                 410                 415     


Asn Ser Val Thr Gly Phe Ser Asn Lys Gly Leu Gln Lys Val Lys Arg 
            420                 425                 430         


Asn Lys Asn Leu Glu Ile Pro Lys Gln His Asn Gly Val Thr Ile Thr 
        435                 440                 445             


Glu Ile Gly Asp Asn Ala Phe Arg Asn Val Asp Phe Gln Asn Lys Thr 
    450                 455                 460                 


Leu Arg Lys Tyr Asp Leu Glu Glu Val Lys Leu Pro Ser Thr Ile Arg 
465                 470                 475                 480 


Lys Ile Gly Ala Phe Ala Phe Gln Ser Asn Asn Leu Lys Ser Phe Glu 
                485                 490                 495     


Ala Ser Asp Asp Leu Glu Glu Ile Lys Glu Gly Ala Phe Met Asn Asn 
            500                 505                 510         


Arg Ile Glu Thr Leu Glu Leu Lys Asp Lys Leu Val Thr Ile Gly Asp 
        515                 520                 525             


Ala Ala Phe His Ile Asn His Ile Tyr Ala Ile Val Leu Pro Glu Ser 
    530                 535                 540                 


Val Gln Glu Ile Gly Arg Ser Ala Phe Arg Gln Asn Gly Ala Asn Asn 
545                 550                 555                 560 


Leu Ile Phe Met Gly Ser Lys Val Lys Thr Leu Gly Glu Met Ala Phe 
                565                 570                 575     


Leu Ser Asn Arg Leu Glu His Leu Asp Leu Ser Glu Gln Lys Gln Leu 
            580                 585                 590         


Thr Glu Ile Pro Val Gln Ala Phe Ser Asp Asn Ala Leu Lys Glu Val 
        595                 600                 605             


Leu Leu Pro Ala Ser Leu Lys Thr Ile Arg Glu Glu Ala Phe Lys Lys 
    610                 615                 620                 


Asn His Leu Lys Gln Leu Glu Val Ala Ser Ala Leu Ser His Ile Ala 
625                 630                 635                 640 


Phe Asn Ala Leu Asp Asp Asn Asp Gly Asp Glu Gln Phe Asp Asn Lys 
                645                 650                 655     


Val Val Val Lys Thr His His Asn Ser Tyr Ala Leu Ala Asp Gly Glu 
            660                 665                 670         


His Phe Ile Val Asp Pro Asp Lys Leu Ser Ser Thr Ile Val Asp Leu 
        675                 680                 685             


Glu Lys Ile Leu Lys Leu Ile Glu Gly Leu Asp Tyr Ser Thr Leu Arg 
    690                 695                 700                 


Gln Thr Thr Gln Thr Gln Phe Arg Asp Met Thr Thr Ala Gly Lys Ala 
705                 710                 715                 720 


Leu Leu Ser Lys Ser Asn Leu Arg Gln Gly Glu Lys Gln Lys Phe Leu 
                725                 730                 735     


Gln Glu Ala Gln Phe Phe Leu Gly Arg Val Asp Leu Asp Lys Ala Ile 
            740                 745                 750         


Ala Lys Ala Glu Lys Ala Leu Val Thr Lys Lys Ala Thr Lys Asn Gly 
        755                 760                 765             


Gln Leu Leu Glu Arg Ser Ile Asn Lys Ala Val Leu Ala Tyr Asn Asn 
    770                 775                 780                 


Ser Ala Ile Lys Lys Ala Asn Val Lys Arg Leu Glu Lys Glu Leu Asp 
785                 790                 795                 800 


Leu Leu Thr Gly Leu Val Glu Gly Lys Gly Pro Leu Ala Gln Ala Thr 
                805                 810                 815     


Met Val Gln Gly Val Tyr Leu Leu Lys Thr Pro Leu Pro Leu Pro Glu 
            820                 825                 830         


Tyr Tyr Ile Gly Leu Asn Val Tyr Phe Asp Lys Ser Gly Lys Leu Ile 
        835                 840                 845             


Tyr Ala Leu Asp Met Ser Asp Thr Ile Gly Glu Gly Gln Lys Asp Ala 
    850                 855                 860                 


Tyr Gly Asn Pro Ile Leu Asn Val Asp Glu Asp Asn Glu Gly Tyr His 
865                 870                 875                 880 


Ala Leu Ala Val Ala Thr Leu Ala Asp Tyr Glu Gly Leu Asp Ile Lys 
                885                 890                 895     


Thr Ile Leu Asn Ser Lys Leu Ser Gln Leu Thr Ser Ile Arg Gln Val 
            900                 905                 910         


Pro Thr Ala Ala Tyr His Arg Ala Gly Ile Phe Gln Ala Ile Gln Asn 
        915                 920                 925             


Ala Ala Ala Glu Ala Glu Gln Leu Leu Pro Lys Pro Gly Thr His Ser 
    930                 935                 940                 


Glu Lys Ser Ser Ser Ser Glu Ser Ala Asn Ser Lys Asp Arg Gly Leu 
945                 950                 955                 960 


Gln Ser Asn Pro Lys Thr Asn Arg Gly Arg His Ser Ala Ile Leu Pro 
                965                 970                 975     


Arg Thr Gly Ser Lys Gly Ser Phe Val Tyr Gly Ile Leu Gly Tyr Thr 
            980                 985                 990         


Ser Val Ala Leu Leu Ser Leu Ile  Thr Ala Ile Lys Lys  Lys Lys Tyr 
        995                 1000                 1005             


<210>  7
<211>  1505
<212>  DNA
<213>  Streptococcus pyogenes

<400>  7
atgaaaaaga aaattctttt aatgatgagt ttaatcagtg tcttttttgc ttggcaactt     60

actcaggcaa aacaagtctt agcagagggt aaagtgaagg tggtgacaac tttctatcct    120

gtttatgaat ttacaaaagg ggttattggt aatgatggcg atgttttcat gcttatgaaa    180

gcaggaacgg aacctcatga ttttgagcct tctacaaaag acattaaaaa aatccaagat    240

gcagatgcat ttgtttatat ggatgacaat atggaaactt gggtttctga tgtgaaaaaa    300

tcattgacat ctaaaaaagt gaccatcgtc aagggaactg gtaacatgct cttggtagca    360

ggagctggac atgaccatcc ccatgaggat gctgacaaaa agcatgagca taataaacat    420

agcgaagaag gacacaacca tgcttttgac ccacacgtgt ggttgtcacc ataccgtagc    480

attacagtcg ttgaaaatat tcgcgacagt ctttcaaaag cttacccaga aaaagcagag    540

aacttcaaag ccaatgccgc tacttatatt gaaaaattaa aagagcttga caaagactat    600

acggcagcac tttcagatgc taagcaaaag agctttgtga cacaacacgc agcttttggt    660

tatatggcac ttgactatgg cttgaaccaa atttctatta atggtgtcac accagatgca    720

gaaccatcag caaaacgtat tgctactttg tcaaaatacg ttaaaaaata tggcatcaaa    780

tacatttatt ttgaggaaaa tgcgtcaagt aaagtcgcaa aaaccctagc taaagaagca    840

ggagttaaag cggctgtgct tagtccgctt gaaggtttga ctgaaaaaga gatgaaagct    900

ggccaagatt actttacggt catgcgtaaa aaccttgaaa ccttacgctt aaccactgat    960

gtggctggta aagaaattct tccagaaaaa gacacgacta agacagttta caatggttat   1020

ttcaaagaca aagaagtcaa agatcgtcaa ttatctgact ggtcaggtag ctggcaatct   1080

gtttacccct atctacaaga tggtacttta gaccaagttt gggactacaa ggctaaaaaa   1140

tctaaaggta aaatgacagc agccgagtac aaagattact acactactgg ttataaaact   1200

gacgtggaac aaatcaaaat caatggtaag aaaaagacca tgacctttgt tcgtaatggt   1260

gaaaagaaaa ccttcactta cacatacgcc ggcaaagaaa tcttgaccta tccaaaagga   1320

aatcgcgggg ttcgtttcat gtttgaagct aaagaagcag atgctggcga attcaaatac   1380

gttcaattca gtgaccatgc cattgctcct gaaaaagcaa agcatttcca cctgtactgg   1440

ggtggtgaca gccaagaaaa attacataaa gagttagaac attggccaac ttactacggt   1500

tcaga                                                               1505


<210>  8
<211>  515
<212>  PRT
<213>  Streptococcus pyogenes

<400>  8

Met Lys Lys Lys Ile Leu Leu Met Met Ser Leu Ile Ser Val Phe Phe 
1               5                   10                  15      


Ala Trp Gln Leu Thr Gln Ala Lys Gln Val Leu Ala Glu Gly Lys Val 
            20                  25                  30          


Lys Val Val Thr Thr Phe Tyr Pro Val Tyr Glu Phe Thr Lys Gly Val 
        35                  40                  45              


Ile Gly Asn Asp Gly Asp Val Phe Met Leu Met Lys Ala Gly Thr Glu 
    50                  55                  60                  


Pro His Asp Phe Glu Pro Ser Thr Lys Asp Ile Lys Lys Ile Gln Asp 
65                  70                  75                  80  


Ala Asp Ala Phe Val Tyr Met Asp Asp Asn Met Glu Thr Trp Val Ser 
                85                  90                  95      


Asp Val Lys Lys Ser Leu Thr Ser Lys Lys Val Thr Ile Val Lys Gly 
            100                 105                 110         


Thr Gly Asn Met Leu Leu Val Ala Gly Ala Gly His Asp His Pro His 
        115                 120                 125             


Glu Asp Ala Asp Lys Lys His Glu His Asn Lys His Ser Glu Glu Gly 
    130                 135                 140                 


His Asn His Ala Phe Asp Pro His Val Trp Leu Ser Pro Tyr Arg Ser 
145                 150                 155                 160 


Ile Thr Val Val Glu Asn Ile Arg Asp Ser Leu Ser Lys Ala Tyr Pro 
                165                 170                 175     


Glu Lys Ala Glu Asn Phe Lys Ala Asn Ala Ala Thr Tyr Ile Glu Lys 
            180                 185                 190         


Leu Lys Glu Leu Asp Lys Asp Tyr Thr Ala Ala Leu Ser Asp Ala Lys 
        195                 200                 205             


Gln Lys Ser Phe Val Thr Gln His Ala Ala Phe Gly Tyr Met Ala Leu 
    210                 215                 220                 


Asp Tyr Gly Leu Asn Gln Ile Ser Ile Asn Gly Val Thr Pro Asp Ala 
225                 230                 235                 240 


Glu Pro Ser Ala Lys Arg Ile Ala Thr Leu Ser Lys Tyr Val Lys Lys 
                245                 250                 255     


Tyr Gly Ile Lys Tyr Ile Tyr Phe Glu Glu Asn Ala Ser Ser Lys Val 
            260                 265                 270         


Ala Lys Thr Leu Ala Lys Glu Ala Gly Val Lys Ala Ala Val Leu Ser 
        275                 280                 285             


Pro Leu Glu Gly Leu Thr Glu Lys Glu Met Lys Ala Gly Gln Asp Tyr 
    290                 295                 300                 


Phe Thr Val Met Arg Lys Asn Leu Glu Thr Leu Arg Leu Thr Thr Asp 
305                 310                 315                 320 


Val Ala Gly Lys Glu Ile Leu Pro Glu Lys Asp Thr Thr Lys Thr Val 
                325                 330                 335     


Tyr Asn Gly Tyr Phe Lys Asp Lys Glu Val Lys Asp Arg Gln Leu Ser 
            340                 345                 350         


Asp Trp Ser Gly Ser Trp Gln Ser Val Tyr Pro Tyr Leu Gln Asp Gly 
        355                 360                 365             


Thr Leu Asp Gln Val Trp Asp Tyr Lys Ala Lys Lys Ser Lys Gly Lys 
    370                 375                 380                 


Met Thr Ala Ala Glu Tyr Lys Asp Tyr Tyr Thr Thr Gly Tyr Lys Thr 
385                 390                 395                 400 


Asp Val Glu Gln Ile Lys Ile Asn Gly Lys Lys Lys Thr Met Thr Phe 
                405                 410                 415     


Val Arg Asn Gly Glu Lys Lys Thr Phe Thr Tyr Thr Tyr Ala Gly Lys 
            420                 425                 430         


Glu Ile Leu Thr Tyr Pro Lys Gly Asn Arg Gly Val Arg Phe Met Phe 
        435                 440                 445             


Glu Ala Lys Glu Ala Asp Ala Gly Glu Phe Lys Tyr Val Gln Phe Ser 
    450                 455                 460                 


Asp His Ala Ile Ala Pro Glu Lys Ala Lys His Phe His Leu Tyr Trp 
465                 470                 475                 480 


Gly Gly Asp Ser Gln Glu Lys Leu His Lys Glu Leu Glu His Trp Pro 
                485                 490                 495     


Thr Tyr Tyr Gly Ser Asp Leu Ser Gly Arg Glu Ile Ala Gln Glu Ile 
            500                 505                 510         


Asn Ala His 
        515 


<210>  9
<211>  1629
<212>  DNA
<213>  Streptococcus pyogenes

<400>  9
gtgtcaaaat acctaaaata cttctctatt atcacgttat ttttgactgg gcttatttta     60

gttgcatgtc aacaacaaaa gcctcaaaca aaagaacgtc agcgcaaaca acgtccaaaa    120

gacgaacttg tcgtttctat gggggcaaag ctccctcatg aattcgatcc aaaggaccgt    180

tatggagtcc acaatgaagg gaatatcact catagcactc tattgaaacg ttctcctgaa    240

ctagatataa aaggagagct tgctaaaaca taccatctct ctgaagatgg gctgacttgg    300

tcgtttgact tgcatgatga ttttaaattc tcaaatggtg agcctgttac tgctgatgat    360

gttaagttta cttatgatat gttgaaagca gatggaaagg cttgggatct aaccttcatt    420

aagaacgttg aagtagttgg gaaaaatcag gtcaatatcc atttgactga ggcgcattcg    480

acatttacag cacagttgac tgaaatccca atcgtcccta aaaaacatta caatgataag    540

tataagagca atcctatcgg ttcaggacct tacatggtaa aagaatataa ggctggagaa    600

caagctattt ttgttcgtaa cccttattgg catgggaaaa aaccatactt taaaaaatgg    660

acttgggtct tacttgatga aaacacagca ctagcagctt tagaatctgg tgatgttgat    720

atgatctacg caacgccaga acttgctgat aaaaaagtca aaggcacccg cctccttgat    780

attccatcaa atgatgtgcg cggcttatca ttaccttatg tgaaaaaggg cgtcatcact    840

gattctcctg atggttatcc tgtaggaaat gatgtcacta gtgatccagc aatccgaaaa    900

gccttgacta ttggtttaaa taggcaaaaa gttctcgata cggttttaaa tggttatggt    960

aaaccagctt attcaattat tgataaaaca ccattttgga atccaaaaac agccattaaa   1020

gataataaag tagctaaagc taagcaatta ttgacaaaag cgggatggaa agaacaagca   1080

gacggtagcc gtaaaaaagg tgaccttgat gcagcgtttg atctgtacta ccctactaat   1140

gatcaattgc gagcgaactt agccgttgaa gtagcagagc aagccaaggc cctagggatt   1200

actattaaac tcaaagctag taactgggat gaaatggcaa cgaagtcaca tgactcagcc   1260

ttactttatg ccggaggacg tcatcacgcg cagcaatttt atgaatcgca tcatccaagc   1320

ctagcaggga aaggttggac caatattacg ttttataaca atcctaccgt gactaagtac   1380

cttgacaaag caatgacatc ttctgacctt gataaagcta acgaatattg gaagttagcg   1440

cagtgggatg gcaaaacagg tgcttctact cttggagatt tgccaaatgt atggttggtg   1500

agccttaacc atacttatat tggtgataaa cgtatcaatg taggtaaaca aggcgtccac   1560

agtcatggtc atgattggtc attattgact aacattgccg agtggacttg ggatgaatca   1620

actaagtaa                                                           1629


<210>  10
<211>  542
<212>  PRT
<213>  Streptococcus pyogenes

<400>  10

Val Ser Lys Tyr Leu Lys Tyr Phe Ser Ile Ile Thr Leu Phe Leu Thr 
1               5                   10                  15      


Gly Leu Ile Leu Val Ala Cys Gln Gln Gln Lys Pro Gln Thr Lys Glu 
            20                  25                  30          


Arg Gln Arg Lys Gln Arg Pro Lys Asp Glu Leu Val Val Ser Met Gly 
        35                  40                  45              


Ala Lys Leu Pro His Glu Phe Asp Pro Lys Asp Arg Tyr Gly Val His 
    50                  55                  60                  


Asn Glu Gly Asn Ile Thr His Ser Thr Leu Leu Lys Arg Ser Pro Glu 
65                  70                  75                  80  


Leu Asp Ile Lys Gly Glu Leu Ala Lys Thr Tyr His Leu Ser Glu Asp 
                85                  90                  95      


Gly Leu Thr Trp Ser Phe Asp Leu His Asp Asp Phe Lys Phe Ser Asn 
            100                 105                 110         


Gly Glu Pro Val Thr Ala Asp Asp Val Lys Phe Thr Tyr Asp Met Leu 
        115                 120                 125             


Lys Ala Asp Gly Lys Ala Trp Asp Leu Thr Phe Ile Lys Asn Val Glu 
    130                 135                 140                 


Val Val Gly Lys Asn Gln Val Asn Ile His Leu Thr Glu Ala His Ser 
145                 150                 155                 160 


Thr Phe Thr Ala Gln Leu Thr Glu Ile Pro Ile Val Pro Lys Lys His 
                165                 170                 175     


Tyr Asn Asp Lys Tyr Lys Ser Asn Pro Ile Gly Ser Gly Pro Tyr Met 
            180                 185                 190         


Val Lys Glu Tyr Lys Ala Gly Glu Gln Ala Ile Phe Val Arg Asn Pro 
        195                 200                 205             


Tyr Trp His Gly Lys Lys Pro Tyr Phe Lys Lys Trp Thr Trp Val Leu 
    210                 215                 220                 


Leu Asp Glu Asn Thr Ala Leu Ala Ala Leu Glu Ser Gly Asp Val Asp 
225                 230                 235                 240 


Met Ile Tyr Ala Thr Pro Glu Leu Ala Asp Lys Lys Val Lys Gly Thr 
                245                 250                 255     


Arg Leu Leu Asp Ile Pro Ser Asn Asp Val Arg Gly Leu Ser Leu Pro 
            260                 265                 270         


Tyr Val Lys Lys Gly Val Ile Thr Asp Ser Pro Asp Gly Tyr Pro Val 
        275                 280                 285             


Gly Asn Asp Val Thr Ser Asp Pro Ala Ile Arg Lys Ala Leu Thr Ile 
    290                 295                 300                 


Gly Leu Asn Arg Gln Lys Val Leu Asp Thr Val Leu Asn Gly Tyr Gly 
305                 310                 315                 320 


Lys Pro Ala Tyr Ser Ile Ile Asp Lys Thr Pro Phe Trp Asn Pro Lys 
                325                 330                 335     


Thr Ala Ile Lys Asp Asn Lys Val Ala Lys Ala Lys Gln Leu Leu Thr 
            340                 345                 350         


Lys Ala Gly Trp Lys Glu Gln Ala Asp Gly Ser Arg Lys Lys Gly Asp 
        355                 360                 365             


Leu Asp Ala Ala Phe Asp Leu Tyr Tyr Pro Thr Asn Asp Gln Leu Arg 
    370                 375                 380                 


Ala Asn Leu Ala Val Glu Val Ala Glu Gln Ala Lys Ala Leu Gly Ile 
385                 390                 395                 400 


Thr Ile Lys Leu Lys Ala Ser Asn Trp Asp Glu Met Ala Thr Lys Ser 
                405                 410                 415     


His Asp Ser Ala Leu Leu Tyr Ala Gly Gly Arg His His Ala Gln Gln 
            420                 425                 430         


Phe Tyr Glu Ser His His Pro Ser Leu Ala Gly Lys Gly Trp Thr Asn 
        435                 440                 445             


Ile Thr Phe Tyr Asn Asn Pro Thr Val Thr Lys Tyr Leu Asp Lys Ala 
    450                 455                 460                 


Met Thr Ser Ser Asp Leu Asp Lys Ala Asn Glu Tyr Trp Lys Leu Ala 
465                 470                 475                 480 


Gln Trp Asp Gly Lys Thr Gly Ala Ser Thr Leu Gly Asp Leu Pro Asn 
                485                 490                 495     


Val Trp Leu Val Ser Leu Asn His Thr Tyr Ile Gly Asp Lys Arg Ile 
            500                 505                 510         


Asn Val Gly Lys Gln Gly Val His Ser His Gly His Asp Trp Ser Leu 
        515                 520                 525             


Leu Thr Asn Ile Ala Glu Trp Thr Trp Asp Glu Ser Thr Lys 
    530                 535                 540         


