                               SEQUENCE LISTING	

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> POLYNUCLEOTIDES ENCODING A HUMAN TRIM-CYP FUSION POLYPEPTIDE, 
      COMPOSITIONS THEREOF, AND METHODS OF USING SAME

<130> 19240-793 WO1

<140> PCT/US2009/063481
<141> 2009-11-06

<150> 61/112,013
<151> 2008-11-06

<150> 61/240,505
<151> 2008-09-08

<160> 149   

<170> PatentIn version 3.5

<210> 1
<211> 2990
<212> DNA
<213> Homo sapiens

<400> 1
gcggttcctc taggaaaatt cctttgtgca gatcaggccc gtggattggt gagtgaatcc       60

taaccacgtc ttccctggcc tgtcttcact cttctcccca gaatcaccac ttctgcactg      120

gtgtctgaag gtgtattgag tgattttgtg gagggcagaa gtaggaagtc tttgggacaa      180

aactgtattt accttgggat ctgtgaacaa gaggaacctc agcagccagg acaggcagga      240

gcagtggaat agctactatg gcttctggaa tcctggttaa tgtaaaggag gaggtgacct      300

gccccatctg cctggaactc ctgacacaac ccctgagcct ggactgcggc cacagcttct      360

gccaagcatg cctcactgca aaccacaaga agtccatgct agacaaagga gagagtagct      420

gccctgtgtg ccggatcagt taccagcctg agaacatacg gcctaatcgg catgtagcca      480

acttagtgga gaagctcagg gaggtcaagt tgagcccaga ggggcagaaa gttgatcatt      540

gtgcacgcca tggagagaaa cttctactct tctgtcagga ggacgggaag gtcatttgct      600

ggctttgtga gcggtctcag gagcaccgtg gtcaccacac gttccccaca gaggaggttg      660

cccaggagta ccaagtgaag ctccaggcag ctctggagat gctgaggcag aagcagcagg      720

aagctgaaga gttggaagct gacatcagag aagagaaagc ttcctggaag actcaaatac      780

agtatgacaa aaccaacgtc ttggcagatt ttgagcaact gagagacatc ctggactggg      840

aggagagcaa tgagctgcaa aacctggaga aggaggagga agacattctg aaaagcctta      900

cgaactctga aactgagatg gtgcagcaga cccagtccct gagagagctc atctcagatc      960

tggagcatcg gctgcagggg tcagtgatgg agctgcttca gggtgtggat ggcgtcataa     1020

aaaggacgga gaacgtgacc ttgaagaagc cagaaacttt tccaaaaaat caaaggagag     1080

tgtttcgagc tcctgatctg aaaggaatgc tagaagtgtt tagagagctg acagatgtcc     1140

gacgctactg ggttgatgtg acagtggctc caaacaacat ttcatgtgct gtcatttctg     1200

aagataagag acaagtgagc tctccgaaac cacagataat atatggggca cgagggacaa     1260

gataccagac atttgtgaat ttcaattatt gtactggcat cctgggctct caaagtatca     1320

catcagggaa acattactgg gaggtagacg tgtccaagaa aactgcttgg atcctggggg     1380

tatgtgctgg cttccaacct gatgcaatgt gtaatattga aaaaaatgaa aattatcaac     1440

ctaaatacgg ctactgggtt atagggttag aggaaggagt taaatgtagt gctttccagg     1500

atagttcctt ccatactcct tctgttcctt tcattgtgcc cctctctgtg attatttgtc     1560

ctgatcgtgt tggagttttc ctagactatg aggcttgcac tgtctcattc ttcaatatca     1620

caaaccatgg atttctcatc tataagtttt ctcactgttc tttttctcag cctgtatttc     1680

catatttaaa tcctagaaaa tgtggagtcc ccatgactct gtgctcacca agctcttgaa     1740

ccttcttaca cactcagccc cttctgtaca gcacctcttg tccaggtgca tctcatacac     1800

ctgaactcat ttgcatcatt ttaaccatct tttccttgct gtctcccttc tttctatttg     1860

aacgtccttc actcatcagt aaaatgtaat aattgccttg tgccatattg tccccaatat     1920

tttattgaca tttgatagca atttttttca tcattttccg tactcctaag gaaaactgac     1980

ctatacctca taaaatgaga ccgctattta ggtattactt ctgccagata tttatcaccc     2040

aattgcctct gacactgact aagaagatga agaaaagctt ttcaacagcc tttctatatc     2100

atcgtgtgat aattgttcac caatgaatga gtccttagcc ctgtgtcagt ttaccctcga     2160

tgcccttatt tgtgagttaa agagaaaata tcataaatgg tatactctta agtatagagg     2220

ttttgtatct agaggatctc agttcaactc ctgtctctcc atataccagc agtgtaactg     2280

tgaataacat acttaaatgg ctgtgcttat ttccttttct tttctttttt cttttttttt     2340

ttttttgaga tgaagttttg ctcttgttcc ccaggctgga gtgcaatggc acgatctcgg     2400

ttcactgcaa cctccacctc tcagattcaa gcaattctcc tgcctcagcc tcccaagtag     2460

ctgggattac aggtgcccac caccacccct ggctaaattt gtattttcag tagagacggg     2520

gtttccccat gttggttagg ctcgtctaga acctctgacc tcaggtgatc cacccgcctc     2580

ggcctcccaa agtgctggga ttacaggcgt gagccacggc gcccagcctg tgcttatttt     2640

cttaaaataa tttttgtatt aaaaacttca cattaaataa gtgctaatgt tttattgcat     2700

agtagggtga ctagagttaa caataaccta ttgcatatat tttgaaatag ctagaagaga     2760

ggattttgaa agttctcaac acaaagaaac gacacatatt tgaggtgatg gatatgctaa     2820

ttaccctggt tcggttatta cgcaatgtat acatgtatca aaacatcaca ctgtaccaca     2880

taaatatgta tatttattat ttgtcaatta aaagcaaaat aaaacaaaaa accttcatct     2940

aatactttgg atcattgtga aaaaataaat tcctgaagta taaagcatct                2990


<210> 2
<211> 493
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln Val 
305                 310                 315                 320 


Ser Ser Pro Lys Pro Gln Ile Ile Tyr Gly Ala Arg Gly Thr Arg Tyr 
                325                 330                 335     


Gln Thr Phe Val Asn Phe Asn Tyr Cys Thr Gly Ile Leu Gly Ser Gln 
            340                 345                 350         


Ser Ile Thr Ser Gly Lys His Tyr Trp Glu Val Asp Val Ser Lys Lys 
        355                 360                 365             


Thr Ala Trp Ile Leu Gly Val Cys Ala Gly Phe Gln Pro Asp Ala Met 
    370                 375                 380                 


Cys Asn Ile Glu Lys Asn Glu Asn Tyr Gln Pro Lys Tyr Gly Tyr Trp 
385                 390                 395                 400 


Val Ile Gly Leu Glu Glu Gly Val Lys Cys Ser Ala Phe Gln Asp Ser 
                405                 410                 415     


Ser Phe His Thr Pro Ser Val Pro Phe Ile Val Pro Leu Ser Val Ile 
            420                 425                 430         


Ile Cys Pro Asp Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Cys Thr 
        435                 440                 445             


Val Ser Phe Phe Asn Ile Thr Asn His Gly Phe Leu Ile Tyr Lys Phe 
    450                 455                 460                 


Ser His Cys Ser Phe Ser Gln Pro Val Phe Pro Tyr Leu Asn Pro Arg 
465                 470                 475                 480 


Lys Cys Gly Val Pro Met Thr Leu Cys Ser Pro Ser Ser 
                485                 490             


<210> 3
<211> 2276
<212> DNA
<213> Homo sapiens

<400> 3
gaacgtggta taaaaggggc gggaggccag gctcgtgccg ttttgcagac gccaccgccg       60

aggaaaaccg tgtactatta gccatggtca accccaccgt gttcttcgac attgccgtcg      120

acggcgagcc cttgggccgc gtctcctttg agctgtttgc agacaaggtc ccaaagacag      180

cagaaaattt tcgtgctctg agcactggag agaaaggatt tggttataag ggttcctgct      240

ttcacagaat tattccaggg tttatgtgtc agggtggtga cttcacacgc cataatggca      300

ctggtggcaa gtccatctat ggggagaaat ttgaagatga gaacttcatc ctaaagcata      360

cgggtcctgg catcttgtcc atggcaaatg ctggacccaa cacaaatggt tcccagtttt      420

tcatctgcac tgccaagact gagtggttgg atggcaagca tgtggtgttt ggcaaagtga      480

aagaaggcat gaatattgtg gaggccatgg agcgctttgg gtccaggaat ggcaagacca      540

gcaagaagat caccattgct gactgtggac aactcgaata agtttgactt gtgttttatc      600

ttaaccacca gatcattcct tctgtagctc aggagagcac ccctccaccc catttgctcg      660

cagtatccta gaatctttgt gctctcgctg cagttccctt tgggttccat gttttccttg      720

ttccctccca tgcctagctg gattgcagag ttaagtttat gattatgaaa taaaaactaa      780

ataacaattg tcctcgtttg agttaagagt gttgatgtag gctttatttt aagcagtaat      840

gggttacttc tgaaacatca cttgtttgct taattctaca cagtacttag atttttttta      900

ctttccagtc ccaggaagtg tcaatgtttg ttgagtggaa tattgaaaat gtaggcagca      960

actgggcatg gtggctcact gtctgtaatg tattacctga ggcagaagac cacctgaggg     1020

taggagtcaa gatcagcctg ggcaacatag tgagacgctg tctctacaaa aaataattag     1080

cctggcctgg tggtgcatgc ctagtcctag ctgatctgga ggctgacgtg ggaggattgc     1140

ttgagcctag agtgagctat tatcatgcca ctgtacagcc tgggtgttca cagatcttgt     1200

gtctcaaagg taggcagagg caggaaaagc aaggagccag aattaagagg ttgggtcagt     1260

ctgcagtgag ttcatgcatt tagaggtgtt cttcaagatg actaatgtca aaaattgaga     1320

catctgttgc ggtttttttt tttttttttt cccctggaat gcagtggcgt gatctcagct     1380

cactgcagcc tccgcctcct gggttcaagt gattctagtg cctcagcctc ctgagtagct     1440

gggataatgg gcgtgtgcca ccatgcccag ctaatttttg tatttttagt atagatgggg     1500

tttcatcatt ttgaccaggc tggtctcaaa ctcttgacct cagctgatgc gcctgccttg     1560

gcctcccaaa ctgctgagat tacagatgtg agccaccgca ccctacctca ttttctgtaa     1620

caaagctaag cttgaacact gttgatgttc ttgagggaag catattgggc tttaggctgt     1680

aggtcaagtt tatacatctt aattatggtg gaattcctat gtagagtcta aaaagccagg     1740

tacttggtgc tacagtcagt ctccctgcag agggttaagg cgcagactac ctgcagtgag     1800

gaggtactgc ttgtagcata tagagcctct ccctagcttt ggttatggag gctttgaggt     1860

tttgcaaacc tgaccaattt aagccataag atctggtcaa agggataccc ttcccactaa     1920

ggacttggtt tctcaggaaa ttatatgtac agtgcttgct ggcagttaga tgtcaggaca     1980

atctaagctg agaaaacccc ttctctgccc accttaacag acctctaggg ttcttaaccc     2040

agcaatcaag tttgcctatc ctagaggtgg cggatttgat catttggtgt gttgggcaat     2100

ttttgtttta ctgtctggtt ccttctgcgt gaattaccac caccaccact tgtgcatctc     2160

agtcttgtgt gttgtctggt tacgtattcc ctgggtgata ccattcaatg tcttaatgta     2220

cttgtggctc agacctgagt gcaaggtgga aataaacatc aaacatcttt tcatta         2276


<210> 4
<211> 165
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210> 5
<211> 1487
<212> DNA
<213> Homo sapiens

<400> 5
atggcttctg gaatcctggt taatgtaaag gaggaggtga cctgccccat ctgcctggaa       60

ctcctgacac aacccctgag cctggactgc ggccacagct tctgccaagc atgcctcact      120

gcaaaccaca agaagtccat gctagacaaa ggagagagta gctgccctgt gtgccggatc      180

agttaccagc ctgagaacat acggcctaat cggcatgtag ccaacttagt ggagaagctc      240

agggaggtca agttgagccc agaggggcag aaagttgatc attgtgcacg ccatggagag      300

aaacttctac tcttctgtca ggaggacggg aaggtcattt gctggctttg tgagcggtct      360

caggagcacc gtggtcacca cacgttcccc acagaggagg ttgcccagga gtaccaagtg      420

aagctccagg cagctctgga gatgctgagg cagaagcagc aggaagctga agagttggaa      480

gctgacatca gagaagagaa agcttcctgg aagactcaaa tacagtatga caaaaccaac      540

gtcttggcag attttgagca actgagagac atcctggact gggaggagag caatgagctg      600

caaaacctgg agaaggagga ggaagacatt ctgaaaagcc ttacgaactc tgaaactgag      660

atggtgcagc agacccagtc cctgagagag ctcatctcag atctggagca tcggctgcag      720

gggtcagtga tggagctgct tcagggtgtg gatggcgtca taaaaaggac ggagaacgtg      780

accttgaaga agccagaaac ttttccaaaa aatcaaagga gagtgtttcg agctcctgat      840

ctgaaaggaa tgctagaagt gtttagagag ctgacagatg tccgacgcta ctgggttgat      900

gtgacagtgg ctccaaacaa catttcatgt gctgtcattt ctgaagataa gagacaagtg      960

agctctccga aaccacagat aatatatggg gcagtcaacc ccaccgtgtt cttcgacatt     1020

gccgtcgacg gcgagccctt gggccgcgtc tcctttgagc tgtttgcgac aaggtcccaa     1080

agacagcaga aaattttcgt gctctgagca ctggagagaa aggatttggt tataagggtt     1140

cctgctttca cagaattatt ccagggttta tgtgtcaggg tggtgacttc acacgccata     1200

atggcactgg tggcaagtcc atctatgggg agaaatttga agatgagaac ttcatcctaa     1260

agcatacggg tcctggcatc ttgtccatgg caaatgctgg acccaacaca aatggttccc     1320

agtttttcat ctgcactgcc aagactgagt ggttggatgg caagcatgtg gtgtttggca     1380

aagtgaaaga aggcatgaat attgtggagg ccatggagcg ctttgggtcc aggaatggca     1440

agaccagcaa gaagatcacc attgctgact gtggacaact cgaataa                   1487


<210> 6
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 6
atggcttctg gaatcctggt taatgtaaag gaggaggtga cctgccccat ctgcctggaa       60

ctcctgacac aacccctgag cctggactgc ggccacagct tctgccaagc atgcctcact      120

gcaaaccaca agaagtccat gctagacaaa ggagagagta gctgccctgt gtgccggatc      180

agttaccagc ctgagaacat acggcctaat cggcatgtag ccaacatagt ggagaagctc      240

agggaggtca agttgagccc agaggggcag aaagttgatc attgtgcacg ccatggagag      300

aaacttctac tcttctgtca ggaggacggg aaggtcattt gctggctttg tgagcggtct      360

caggagcacc gtggtcacca cacgttcctc acagaggagg ttgcccggga gtaccaagtg      420

aagctccagg cagctctgga gatgctgagg cagaagcagc aggaagctga agagttggaa      480

gctgacatca gagaagagaa agcttcctgg aagactcaaa tacagtatga caaaaccaac      540

gtcttggcag attttgagca actgagagac atcctggact gggaggagag caatgagctg      600

caaaacctgg agaaggagga ggaagacatt ctgaaaagcc ttacgaactc tgaaactgag      660

atggtgcagc agacccagtc cctgagagag ctcatctcag atctggagca tcggctgcag      720

gggtcagtga tggagctgct tcagggtgtg gatggcgtca taaaaaggac ggagaacgtg      780

accttgaaga agccagaaac ttttccaaaa aatcaaagga gagtgtttcg agctcctgat      840

ctgaaaggaa tgctagaagt gtttagagag ctgacagatg tccgacgcta ctgggttgat      900

gtgacagtgg ctccaaacaa catttcagtc aaccccaccg tgttcttcga cattgccgtc      960

gacggcgagc ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca     1020

gcagaaaatt ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc     1080

tttcacagaa ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc     1140

actggtggca agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat     1200

acgggtcctg gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt     1260

ttcatctgca ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg     1320

aaagaaggca tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc     1380

agcaagaaga tcaccattgc tgactgtgga caactcgaat aa                        1422


<210> 7
<211> 1461
<212> DNA
<213> Homo sapiens

<400> 7
atggcttctg gaatcctggt taatgtaaag gaggaggtga cctgccccat ctgcctggaa       60

ctcctgacac aacccctgag cctggactgc ggccacagct tctgccaagc atgcctcact      120

gcaaaccaca agaagtccat gctagacaaa ggagagagta gctgccctgt gtgccggatc      180

agttaccagc ctgagaacat acggcctaat cggcatgtag ccaacatagt ggagaagctc      240

agggaggtca agttgagccc agaggggcag aaagttgatc attgtgcacg ccatggagag      300

aaacttctac tcttctgtca ggaggacggg aaggtcattt gctggctttg tgagcggtct      360

caggagcacc gtggtcacca cacgttcctc acagaggagg ttgcccggga gtaccaagtg      420

aagctccagg cagctctgga gatgctgagg cagaagcagc aggaagctga agagttggaa      480

gctgacatca gagaagagaa agcttcctgg aagactcaaa tacagtatga caaaaccaac      540

gtcttggcag attttgagca actgagagac atcctggact gggaggagag caatgagctg      600

caaaacctgg agaaggagga ggaagacatt ctgaaaagcc ttacgaactc tgaaactgag      660

atggtgcagc agacccagtc cctgagagag ctcatctcag atctggagca tcggctgcag      720

gggtcagtga tggagctgct tcagggtgtg gatggcgtca taaaaaggac ggagaacgtg      780

accttgaaga agccagaaac ttttccaaaa aatcaaagga gagtgtttcg agctcctgat      840

ctgaaaggaa tgctagaagt gtttagagag ctgacagatg tccgacgcta ctgggttgat      900

gtgacagtgg ctccaaacaa catttcatgt gctgtcattt ctgaagataa gagacaagtg      960

agctctgtca accccaccgt gttcttcgac attgccgtcg acggcgagcc cttgggccgc     1020

gtctcctttg agctgtttgc agacaaggtc ccaaagacag cagaaaattt tcgtgctctg     1080

agcactggag agaaaggatt tggttataag ggttcctgct ttcacagaat tattccaggg     1140

tttatgtgtc agggtggtga cttcacacgc cataatggca ctggtggcaa gtccatctat     1200

ggggagaaat ttgaagatga gaacttcatc ctaaagcata cgggtcctgg catcttatcg     1260

atggcaaatg ctggacccaa cacaaatggt tcccagtttt tcatctgcac tgccaagact     1320

gagtggttgg atggcaagca tgtggtgttt ggcaaagtga aagaaggcat gaatattgtg     1380

gaggcgatgg agcgctttgg gtccaggaat ggcaagacca gcaagaagat caccattgct     1440

gactgtggac aactcgaata a                                               1461


<210> 8
<211> 7836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgctgtg      240

gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca      300

aagcatgcat ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg      360

cagaagtatg caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc      420

gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat      480

tttttttatt tatgcagagg ccgaggccgc ctctgcctct gagctattcc agaagtagtg      540

aggaggcttt tttggaggcc taggcttttg caaaaagctt tgacattgat tattgactag      600

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt      660

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac      720

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg      780

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag      840

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat      900

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat      960

ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt     1020

tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga     1080

ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg     1140

gtgggaggtc tatataagca gcgcgttttg cctgtactgg gtctctctgg ttagaccaga     1200

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     1260

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     1320

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggactt     1380

gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg ctgaagcgcg     1440

cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga ctagcggagg     1500

ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa ttagatcgcg     1560

atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa aacatatagt     1620

atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag aaacatcaga     1680

aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat cagaagaact     1740

tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga tagagataaa     1800

agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta agaccaccgc     1860

acagcaagcg gccggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg     1920

agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc     1980

aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc     2040

cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta     2100

caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt     2160

gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga     2220

atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct     2280

ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg     2340

gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca     2400

agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa     2460

ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg     2520

tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt     2580

gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc     2640

cacctcccaa ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag     2700

agagacagag acagatccat tcgattagtg aacggatcgg cactgcgtgc gccaattctg     2760

cagacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg gggggtacag     2820

tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag aattacaaaa     2880

acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag atccagtttg     2940

gttaattaac tgcagccccg ataaaataaa agattttatt tagtctccag aaaaaggggg     3000

gaatgaaaga ccccacctgt aggtttggca agctagctgc agtaacgcca ttttgcaagg     3060

catggaaaaa taccaaacca agaatagaga agttcagatc aagggcgggt acatgaaaat     3120

agctaacgtt gggccaaaca ggatatctgc ggtgagcagt ttcggccccg gcccggggcc     3180

aagaacagat ggtcaccgca gtttcggccc cggcccgagg ccaagaacag atggtcccca     3240

gatatggccc aaccctcagc agtttcttaa gacccatcag atgtttccag gctcccccaa     3300

ggacctgaaa tgaccctgcg ccttatttga attaaccaat cagcctgctt ctcgcttctg     3360

ttcgcgcgct tctgcttccc gagctctata aaagagctca caacccctca ctcggcgcgc     3420

cagtcctccg acagactgag tcgcccgggg gtctagaagc gctggatccg tttaaacgcg     3480

gccgcccagc acagtggctc gagccgcggg ttaactggcc agaattctcg accttgactg     3540

gcggcgcgac cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg     3600

cgcctcatcg cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg     3660

ccatgctgcc cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc     3720

gccccgcccc gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc     3780

tccgcgcgtt agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc     3840

tataggccag atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg     3900

cgcgagaccg ggttgcgggc ggggccgaac gtggtataaa aggggcggga ggccaggctc     3960

gtgccgtttt gcagacgcca ccgccgagga aaaccgtgta ctattagcca cgcgtgccac     4020

catggcccag tccaagcacg gcctgaccaa ggagatgacc atgaagtacc gcatggaggg     4080

ctgcgtggac ggccacaagt tcgtgatcac cggcgagggc atcggctacc ccttcaaggg     4140

caagcaggcc atcaacctgt gcgtggtgga gggcggcccc ttgcccttcg ccgaggacat     4200

cttgtccgcc gccttcatgt acggcaaccg cgtgttcacc gagtaccccc aggacatcgt     4260

cgactacttc aagaactcct gccccgccgg ctacacctgg gaccgctcct tcctgttcga     4320

ggacggcgcc gtgtgcatct gcaacgccga catcaccgtg agcgtggagg agaactgcat     4380

gtaccacgag tccaagttct acggcgtgaa cttccccgcc gacggccccg tgatgaagaa     4440

gatgaccgac aactgggagc cctcctgcga gaagatcatc cccgtgccca agcagggcat     4500

cttgaagggc gacgtgagca tgtacctgct gctgaaggac ggtggccgct tgcgctgcca     4560

gttcgacacc gtgtacaagg ccaagtccgt gccccgcaag atgcccgact ggcacttcat     4620

ccagcacaag ctgacccgcg aggaccgcag cgacgccaag aaccagaagt ggcacctgac     4680

cgagcacgcc atcgcctccg gctccgcctt gccctgagcg atcgctaatc aacctctgga     4740

ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg     4800

tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt     4860

ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag     4920

gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc     4980

caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga     5040

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     5100

ttccgtggtg ttgtcgggga agctgacgtc ctttccatgg ctgctcgcct gtgttgccac     5160

ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct     5220

tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca     5280

gacgagtcgg atctcccttt gggccgcctc cccgcttaat cgcgtcgaga cctagaaaaa     5340

catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc ctggctagaa     5400

gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt aagaccaatg     5460

acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg actggaaggg     5520

ctaattcact cccaacgaag acaagatatc cttgatctgt ggatctacca cacacaaggc     5580

tacttccctg attggcagaa ctacacacca gggccaggga tcagatatcc actgaccttt     5640

ggatggtgct acaagctagt accagttgag caagagaagg tagaagaagc caatgaagga     5700

gagaacaccc gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa     5760

gtattagagt ggaggtttga cagccgccta gcatttcatc acatggcccg agagctgcat     5820

ccggactgta ctgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa     5880

ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt     5940

gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg     6000

aaaatctcta gcagggcccg tttcatgtga gcaaaaggcc agcaaaaggc caggaaccgt     6060

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     6120

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     6180

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     6240

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     6300

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     6360

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     6420

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     6480

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     6540

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     6600

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     6660

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     6720

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     6780

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     6840

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     6900

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     6960

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     7020

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     7080

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     7140

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca     7200

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa     7260

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca     7320

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt     7380

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt     7440

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg     7500

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga     7560

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc     7620

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg     7680

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag     7740

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     7800

gttccgcgca catttccccg aaaagtgcca cctgac                               7836


<210> 9
<211> 9297
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgctgtg      240

gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca      300

aagcatgcat ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg      360

cagaagtatg caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc      420

gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat      480

tttttttatt tatgcagagg ccgaggccgc ctctgcctct gagctattcc agaagtagtg      540

aggaggcttt tttggaggcc taggcttttg caaaaagctt tgacattgat tattgactag      600

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt      660

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac      720

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg      780

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag      840

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat      900

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat      960

ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt     1020

tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga     1080

ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg     1140

gtgggaggtc tatataagca gcgcgttttg cctgtactgg gtctctctgg ttagaccaga     1200

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     1260

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     1320

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggactt     1380

gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg ctgaagcgcg     1440

cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga ctagcggagg     1500

ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa ttagatcgcg     1560

atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa aacatatagt     1620

atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag aaacatcaga     1680

aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat cagaagaact     1740

tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga tagagataaa     1800

agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta agaccaccgc     1860

acagcaagcg gccggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg     1920

agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc     1980

aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc     2040

cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta     2100

caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt     2160

gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga     2220

atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct     2280

ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg     2340

gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca     2400

agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa     2460

ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg     2520

tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt     2580

gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc     2640

cacctcccaa ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag     2700

agagacagag acagatccat tcgattagtg aacggatcgg cactgcgtgc gccaattctg     2760

cagacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg gggggtacag     2820

tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag aattacaaaa     2880

acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag atccagtttg     2940

gttaattaac tgcagccccg ataaaataaa agattttatt tagtctccag aaaaaggggg     3000

gaatgaaaga ccccacctgt aggtttggca agctagctgc agtaacgcca ttttgcaagg     3060

catggaaaaa taccaaacca agaatagaga agttcagatc aagggcgggt acatgaaaat     3120

agctaacgtt gggccaaaca ggatatctgc ggtgagcagt ttcggccccg gcccggggcc     3180

aagaacagat ggtcaccgca gtttcggccc cggcccgagg ccaagaacag atggtcccca     3240

gatatggccc aaccctcagc agtttcttaa gacccatcag atgtttccag gctcccccaa     3300

ggacctgaaa tgaccctgcg ccttatttga attaaccaat cagcctgctt ctcgcttctg     3360

ttcgcgcgct tctgcttccc gagctctata aaagagctca caacccctca ctcggcgcgc     3420

cagtcctccg acagactgag tcgcccgggg gtctagagcc accatggctt ctggaatcct     3480

ggttaatgta aaggaggagg tgacctgccc catctgcctg gaactcctga cacaacccct     3540

gagcctggac tgcggccaca gcttctgcca agcatgcctc actgcaaacc acaagaagtc     3600

catgctagac aaaggagaga gtagctgccc tgtgtgccgg atcagttacc agcctgagaa     3660

catacggcct aatcggcatg tagccaacat agtggagaag ctcagggagg tcaagttgag     3720

cccagagggg cagaaagttg atcattgtgc acgccatgga gagaaacttc tactcttctg     3780

tcaggaggac gggaaggtca tttgctggct ttgtgagcgg tctcaggagc accgtggtca     3840

ccacacgttc ctcacagagg aggttgcccg ggagtaccaa gtgaagctcc aggcagctct     3900

ggagatgctg aggcagaagc agcaggaagc tgaagagttg gaagctgaca tcagagaaga     3960

gaaagcttcc tggaagactc aaatacagta tgacaaaacc aacgtcttgg cagattttga     4020

gcaactgaga gacatcctgg actgggagga gagcaatgag ctgcaaaacc tggagaagga     4080

ggaggaagac attctgaaaa gccttacgaa ctctgaaact gagatggtgc agcagaccca     4140

gtccctgaga gagctcatct cagatctgga gcatcggctg caggggtcag tgatggagct     4200

gcttcagggt gtggatggcg tcataaaaag gacggagaac gtgaccttga agaagccaga     4260

aacttttcca aaaaatcaaa ggagagtgtt tcgagctcct gatctgaaag gaatgctaga     4320

agtgtttaga gagctgacag atgtccgacg ctactgggtt gatgtgacag tggctccaaa     4380

caacatttca tgtgctgtca tttctgaaga taagagacaa gtgagctctg tcaaccccac     4440

cgtgttcttc gacattgccg tcgacggcga gcccttgggc cgcgtctcct ttgagctgtt     4500

tgcagacaag gtcccaaaga cagcagaaaa ttttcgtgct ctgagcactg gagagaaagg     4560

atttggttat aagggttcct gctttcacag aattattcca gggtttatgt gtcagggtgg     4620

tgacttcaca cgccataatg gcactggtgg caagtccatc tatggggaga aatttgaaga     4680

tgagaacttc atcctaaagc atacgggtcc tggcatctta tcgatggcaa atgctggacc     4740

caacacaaat ggttcccagt ttttcatctg cactgccaag actgagtggt tggatggcaa     4800

gcatgtggtg tttggcaaag tgaaagaagg catgaatatt gtggaggcga tggagcgctt     4860

tgggtccagg aatggcaaga ccagcaagaa gatcaccatt gctgactgtg gacaactcga     4920

ataaggatcc gtttaaacgc ggccgcccag cacagtggct cgagccgcgg gttaactggc     4980

cagaattctc gaccttgact ggcggcgcga ccttgaggcc tgcgttcgcc tcagttgccc     5040

cctctgtgca atggggagac gcgcctcatc gcttgacaac ggccgaagag ccgccgcgct     5100

tccgtctccc gcgtgcgcgc gccatgctgc ccacccccgt tccgcactga ccctcccccg     5160

tgccccgcgt cccgtactgc cgccccgccc cgagtcccat gccgcagcca ccgcgacgga     5220

gcccgcaggc gggaacctgc ctccgcgcgt tagcgcgcac gcgcgcctca tgtgtcgtcc     5280

ccatcagcgc cggcttccgt ctataggcca gatgcactgt cactctggcg aagtcgcaga     5340

cccgattggc cgggacggag gcgcgagacc gggttgcggg cggggccgaa cgtggtataa     5400

aaggggcggg aggccaggct cgtgccgttt tgcagacgcc accgccgagg aaaaccgtgt     5460

actattagcc acgcgtgcca ccatggccca gtccaagcac ggcctgacca aggagatgac     5520

catgaagtac cgcatggagg gctgcgtgga cggccacaag ttcgtgatca ccggcgaggg     5580

catcggctac cccttcaagg gcaagcaggc catcaacctg tgcgtggtgg agggcggccc     5640

cttgcccttc gccgaggaca tcttgtccgc cgccttcatg tacggcaacc gcgtgttcac     5700

cgagtacccc caggacatcg tcgactactt caagaactcc tgccccgccg gctacacctg     5760

ggaccgctcc ttcctgttcg aggacggcgc cgtgtgcatc tgcaacgccg acatcaccgt     5820

gagcgtggag gagaactgca tgtaccacga gtccaagttc tacggcgtga acttccccgc     5880

cgacggcccc gtgatgaaga agatgaccga caactgggag ccctcctgcg agaagatcat     5940

ccccgtgccc aagcagggca tcttgaaggg cgacgtgagc atgtacctgc tgctgaagga     6000

cggtggccgc ttgcgctgcc agttcgacac cgtgtacaag gccaagtccg tgccccgcaa     6060

gatgcccgac tggcacttca tccagcacaa gctgacccgc gaggaccgca gcgacgccaa     6120

gaaccagaag tggcacctga ccgagcacgc catcgcctcc ggctccgcct tgccctgagc     6180

gatcgctaat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     6240

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     6300

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     6360

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     6420

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     6480

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     6540

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg     6600

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     6660

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     6720

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcttaa     6780

tcgcgtcgag acctagaaaa acatggagca atcacaagta gcaatacagc agctaccaat     6840

gctgattgtg cctggctaga agcacaagag gaggaggagg tgggttttcc agtcacacct     6900

caggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa     6960

gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatat ccttgatctg     7020

tggatctacc acacacaagg ctacttccct gattggcaga actacacacc agggccaggg     7080

atcagatatc cactgacctt tggatggtgc tacaagctag taccagttga gcaagagaag     7140

gtagaagaag ccaatgaagg agagaacacc cgcttgttac accctgtgag cctgcatggg     7200

atggatgacc cggagagaga agtattagag tggaggtttg acagccgcct agcatttcat     7260

cacatggccc gagagctgca tccggactgt actgggtctc tctggttaga ccagatctga     7320

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct     7380

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc     7440

agaccctttt agtcagtgtg gaaaatctct agcagggccc gtttcatgtg agcaaaaggc     7500

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     7560

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     7620

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     7680

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     7740

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     7800

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     7860

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     7920

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     7980

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     8040

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     8100

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     8160

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     8220

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     8280

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     8340

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     8400

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg     8460

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     8520

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     8580

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc     8640

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     8700

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     8760

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     8820

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     8880

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     8940

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     9000

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     9060

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     9120

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     9180

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     9240

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgac        9297


<210> 10
<211> 495
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Leu Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln Val 
305                 310                 315                 320 


Ser Ser Pro Lys Pro Gln Ile Ile Tyr Gly Ala Val Asn Pro Thr Val 
                325                 330                 335     


Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe 
            340                 345                 350         


Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala 
        355                 360                 365             


Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His 
    370                 375                 380                 


Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His 
385                 390                 395                 400 


Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu 
                405                 410                 415     


Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn 
            420                 425                 430         


Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys 
        435                 440                 445             


Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu 
    450                 455                 460                 


Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly 
465                 470                 475                 480 


Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
                485                 490                 495 


<210> 11
<211> 473
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Leu Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val 
305                 310                 315                 320 


Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys 
                325                 330                 335     


Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys 
            340                 345                 350         


Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe 
        355                 360                 365             


Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys 
    370                 375                 380                 


Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His 
385                 390                 395                 400 


Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn 
                405                 410                 415     


Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly 
            420                 425                 430         


Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu 
        435                 440                 445             


Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile 
    450                 455                 460                 


Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470             


<210> 12
<211> 486
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Leu Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln Val 
305                 310                 315                 320 


Ser Ser Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu 
                325                 330                 335     


Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys 
            340                 345                 350         


Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly 
        355                 360                 365             


Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln 
    370                 375                 380                 


Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr 
385                 390                 395                 400 


Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro 
                405                 410                 415     


Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln 
            420                 425                 430         


Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val 
        435                 440                 445             


Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu 
    450                 455                 460                 


Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala 
465                 470                 475                 480 


Asp Cys Gly Gln Leu Glu 
                485     


<210> 13
<211> 298
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp 
    290                 295             


<210> 14
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(33)
<223> Any amino acid and this region may encompass 12-33 residues

<400> 14
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210> 15
<211> 164
<212> PRT
<213> Homo sapiens

<400> 15
Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu 
1               5                   10                  15      


Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
            20                  25                  30          


Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
        35                  40                  45              


Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
    50                  55                  60                  


Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
65                  70                  75                  80  


Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                85                  90                  95      


Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
            100                 105                 110         


Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
        115                 120                 125             


Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe 
    130                 135                 140                 


Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys 
145                 150                 155                 160 


Gly Gln Leu Glu 
                


<210> 16
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (299)..(331)
<223> Any amino acid and this region may encompass 12-33 residues

<400> 16
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Asn Pro Thr Val 
                325                 330                 335     


Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe 
            340                 345                 350         


Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala 
        355                 360                 365             


Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His 
    370                 375                 380                 


Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His 
385                 390                 395                 400 


Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu 
                405                 410                 415     


Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn 
            420                 425                 430         


Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys 
        435                 440                 445             


Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu 
    450                 455                 460                 


Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly 
465                 470                 475                 480 


Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
                485                 490                 495 


<210> 17
<211> 474
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Leu Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Ser Gly Gly Ser Gly Gly 
    290                 295                 300                 


Ser Gly Gly Ser Gly Gly Val Asn Pro Thr Val Phe Phe Asp Ile Ala 
305                 310                 315                 320 


Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp 
                325                 330                 335     


Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu 
            340                 345                 350         


Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly 
        355                 360                 365             


Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly 
    370                 375                 380                 


Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys 
385                 390                 395                 400 


His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr 
                405                 410                 415     


Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp 
            420                 425                 430         


Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val 
        435                 440                 445             


Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys 
    450                 455                 460                 


Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470                 


<210> 18
<211> 894
<212> DNA
<213> Homo sapiens

<400> 18
atggcttctg gaatcctggt taatgtaaag gaggaggtga cctgccccat ctgcctggaa       60

ctcctgacac aacccctgag cctggactgc ggccacagct tctgccaagc atgcctcact      120

gcaaaccaca agaagtccat gctagacaaa ggagagagta gctgccctgt gtgccggatc      180

agttaccagc ctgagaacat acggcctaat cggcatgtag ccaacttagt ggagaagctc      240

agggaggtca agttgagccc agaggggcag aaagttgatc attgtgcacg ccatggagag      300

aaacttctac tcttctgtca ggaggacggg aaggtcattt gctggctttg tgagcggtct      360

caggagcacc gtggtcacca cacgttcccc acagaggagg ttgcccagga gtaccaagtg      420

aagctccagg cagctctgga gatgctgagg cagaagcagc aggaagctga agagttggaa      480

gctgacatca gagaagagaa agcttcctgg aagactcaaa tacagtatga caaaaccaac      540

gtcttggcag attttgagca actgagagac atcctggact gggaggagag caatgagctg      600

caaaacctgg agaaggagga ggaagacatt ctgaaaagcc ttacgaactc tgaaactgag      660

atggtgcagc agacccagtc cctgagagag ctcatctcag atctggagca tcggctgcag      720

gggtcagtga tggagctgct tcagggtgtg gatggcgtca taaaaaggac ggagaacgtg      780

accttgaaga agccagaaac ttttccaaaa aatcaaagga gagtgtttcg agctcctgat      840

ctgaaaggaa tgctagaagt gtttagagag ctgacagatg tccgacgcta ctgg            894


<210> 19
<211> 494
<212> DNA
<213> Homo sapiens

<400> 19
gtcaacccca ccgtgttctt cgacattgcc gtcgacggcg agcccttggg ccgcgtctcc       60

tttgagctgt ttgcgacaag gtcccaaaga cagcagaaaa ttttcgtgct ctgagcactg      120

gagagaaagg atttggttat aagggttcct gctttcacag aattattcca gggtttatgt      180

gtcagggtgg tgacttcaca cgccataatg gcactggtgg caagtccatc tatggggaga      240

aatttgaaga tgagaacttc atcctaaagc atacgggtcc tggcatcttg tccatggcaa      300

atgctggacc caacacaaat ggttcccagt ttttcatctg cactgccaag actgagtggt      360

tggatggcaa gcatgtggtg tttggcaaag tgaaagaagg catgaatatt gtggaggcca      420

tggagcgctt tgggtccagg aatggcaaga ccagcaagaa gatcaccatt gctgactgtg      480

gacaactcga ataa                                                        494


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10          


<210> 21
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Val Asp Val Thr Val Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser 
1               5                   10                  15      


Glu Asp Lys Arg Gln Val Ser Ser Pro Lys Pro Gln Ile Ile Tyr Gly 
            20                  25                  30          


Ala 
    


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Val Asp Val Thr Val Ala Pro Asn Asn Ile Ser 
1               5                   10      


<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Val Asp Val Thr Val Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser 
1               5                   10                  15      


Glu Asp Lys Arg Gln Val Ser Ser 
            20                  


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(12)
<223> Any amino acid

<400> 24
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210> 25
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(24)
<223> Any amino acid

<400> 25
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210> 26
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(33)
<223> Any amino acid

<400> 26
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210> 27
<211> 474
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (299)..(310)
<223> Any amino acid

<400> 27
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Val Asn Pro Thr Val Phe Phe Asp Ile Ala 
305                 310                 315                 320 


Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp 
                325                 330                 335     


Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu 
            340                 345                 350         


Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly 
        355                 360                 365             


Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly 
    370                 375                 380                 


Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys 
385                 390                 395                 400 


His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr 
                405                 410                 415     


Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp 
            420                 425                 430         


Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val 
        435                 440                 445             


Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys 
    450                 455                 460                 


Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470                 


<210> 28
<211> 486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (299)..(322)
<223> Any amino acid

<400> 28
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu 
                325                 330                 335     


Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys 
            340                 345                 350         


Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly 
        355                 360                 365             


Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln 
    370                 375                 380                 


Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr 
385                 390                 395                 400 


Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro 
                405                 410                 415     


Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln 
            420                 425                 430         


Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val 
        435                 440                 445             


Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu 
    450                 455                 460                 


Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala 
465                 470                 475                 480 


Asp Cys Gly Gln Leu Glu 
                485     


<210> 29
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (299)..(331)
<223> Any amino acid

<400> 29
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Asn Pro Thr Val 
                325                 330                 335     


Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe 
            340                 345                 350         


Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala 
        355                 360                 365             


Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His 
    370                 375                 380                 


Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His 
385                 390                 395                 400 


Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu 
                405                 410                 415     


Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn 
            420                 425                 430         


Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys 
        435                 440                 445             


Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu 
    450                 455                 460                 


Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly 
465                 470                 475                 480 


Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
                485                 490                 495 


<210> 30
<211> 473
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (299)..(309)
<223> Any amino acid

<400> 30
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val 
305                 310                 315                 320 


Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys 
                325                 330                 335     


Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys 
            340                 345                 350         


Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe 
        355                 360                 365             


Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys 
    370                 375                 380                 


Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His 
385                 390                 395                 400 


Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn 
                405                 410                 415     


Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly 
            420                 425                 430         


Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu 
        435                 440                 445             


Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile 
    450                 455                 460                 


Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470             


<210> 31
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Val Asn Pro Thr Val Phe 
305                 310                 315                 320 


Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu 
                325                 330                 335     


Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu 
            340                 345                 350         


Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg 
        355                 360                 365             


Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn 
    370                 375                 380                 


Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn 
385                 390                 395                 400 


Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala 
                405                 410                 415     


Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr 
            420                 425                 430         


Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly 
        435                 440                 445             


Met Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys 
    450                 455                 460                 


Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470                 475             


<210> 32
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Gly Lys Glu Lys Ser His 
    290                 295                 300                 


Tyr His Lys Pro Pro Cys Gly Leu Ser Val Asn Pro Thr Val Phe Phe 
305                 310                 315                 320 


Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu 
                325                 330                 335     


Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser 
            340                 345                 350         


Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile 
        355                 360                 365             


Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly 
    370                 375                 380                 


Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe 
385                 390                 395                 400 


Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly 
                405                 410                 415     


Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu 
            420                 425                 430         


Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met 
        435                 440                 445             


Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr 
    450                 455                 460                 


Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470                 475         


<210> 33
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Gly Trp Ser Ala Met Ala 
    290                 295                 300                 


Arg Ser Arg Phe Thr Ala Thr Ser Thr Ser Val Asn Pro Thr Val Phe 
305                 310                 315                 320 


Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu 
                325                 330                 335     


Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu 
            340                 345                 350         


Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg 
        355                 360                 365             


Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn 
    370                 375                 380                 


Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn 
385                 390                 395                 400 


Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala 
                405                 410                 415     


Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr 
            420                 425                 430         


Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly 
        435                 440                 445             


Met Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys 
    450                 455                 460                 


Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
465                 470                 475             


<210> 34
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln Val 
305                 310                 315                 320 


Ser Ser Pro Lys Pro Gln Ile Ile Tyr Gly Ala Arg Gly Thr Arg Tyr 
                325                 330                 335     


Gln Thr Phe Val Asn Phe Asn Tyr Cys Thr Gly Ile Leu Gly Ser Gln 
            340                 345                 350         


Ser Ile Thr Ser Gly Lys His Tyr Trp Glu Val Asp Val Ser Lys Lys 
        355                 360                 365             


Thr Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
    370                 375                 380                 


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
385                 390                 395                 400 


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
                405                 410                 415     


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
            420                 425                 430         


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
        435                 440                 445             


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
    450                 455                 460                 


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
465                 470                 475                 480 


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
                485                 490                 495     


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
            500                 505                 510         


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
        515                 520                 525             


Cys Gly Gln Leu Glu 
    530             


<210> 35
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Val Asn Pro Thr 
        275                 280                 285             


Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser 
    290                 295                 300                 


Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg 
305                 310                 315                 320 


Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe 
                325                 330                 335     


His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg 
            340                 345                 350         


His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp 
        355                 360                 365             


Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala 
    370                 375                 380                 


Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala 
385                 390                 395                 400 


Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys 
                405                 410                 415     


Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn 
            420                 425                 430         


Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
        435                 440                 445             


<210> 36
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
ccctctagag ccaccatggc ttctggaatc ctggtta                                37


<210> 37
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
aaaagcggcc gctcaagagc ttggtgagca cagagt                                 36


<210> 38
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
ccctctagag ccaccatggc ttctggaatc ctgctta                                37


<210> 39
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
aaaagttaac tcaagagctt ggtgagcaca                                        30


<210> 40
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
ccctctagag ccaccatggt caaccccacc gtgtt                                  35


<210> 41
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
aaaaggatcc ttattagagt tgtccacagt cagc                                   34


<210> 42
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
ccctctagag ccaccatggc ttctggaatc ctggtta                                37


<210> 43
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
aaaaggatcc ttattcgagt tgtccacagt c                                      31


<210> 44
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
cggctgcagg ggtcagtgat ggtcaacccc accgtgttc                              39


<210> 45
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
gaacacggtg gggttgacca tcactgaccc ctgcagccg                              39


<210> 46
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
gctcctgatc tgaaaggaat ggtcaacccc accgtgttc                              39


<210> 47
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
gaacacggtg gggttgacca ttcctttcag atcaggagc                              39


<210> 48
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
cgctactggg ttgatgtgac agtcaacccc accgtgttc                              39


<210> 49
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
gaacacggtg gggttgactg tcacatcaac ccagtagc                               38


<210> 50
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
gtggctccaa acaacatttc agtcaacccc accgtgttc                              39


<210> 51
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
gaacacggtg gggttgactg aaatgttgtt tggagccac                              39


<210> 52
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
caagtgagct ctgtcaaccc caccgtgttc                                        30


<210> 53
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
ggggttgaca gagctcactt gtctcttatc ttcag                                  35


<210> 54
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
ccacagataa tatatggggc agtcaacccc accgtgttct tc                          42


<210> 55
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
cacggtgggg ttgactgccc catatattat ctgtggtttc g                           41


<210> 56
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
gctctcaaag tatcacatca ggggtcaacc ccaccgtgtt cttc                        44


<210> 57
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
gaagaacacg gtggggttga cccctgatgt gatactttga gagc                        44


<210> 58
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
gaggtagacg tgtccaagaa aactgtcaac cccaccgtgt tcttc                       45


<210> 59
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
gaagaacacg gtggggttga cagttttctt ggacacgtct acctc                       45


<210> 60
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
gaaaattatc aacctaaata cggcgtcaac cccaccgtgt tcttc                       45


<210> 61
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
gaagaacacg gtggggttga cgccgtattt aggttgataa ttttc                       45


<210> 62
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
ctggattgca gagttaagtt ta                                                22


<210> 63
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
tgccaagcat gcctcactgc aa                                                22


<210> 64
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
tcgtgtgata attgttcacc aa                                                22


<210> 65
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
gggtactagt agttcctg                                                     18


<210> 66
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
ggggcggccg ctggtgagag atgggtgcga gagcgtc                                37


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
cggctaccac atccaaggaa                                                   20


<210> 68
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
gctggaatta ccgcggct                                                     18


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
ccccgtgatg aagaagatga                                                   20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
gtcagcttgt gctggatgaa                                                   20


<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 71
ctgggttgat gtgacagtgg                                                   20


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 72
tctgctgtct ttgggacctt                                                   20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 73
cggctaccac atccaaggaa                                                   20


<210> 74
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 74
gctggaatta ccgcggct                                                     18


<210> 75
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 75
tgctggcacc agacttgccc tc                                                22


<210> 76
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 76
acccactccc tcttagccaa tatt                                              24


<210> 77
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 77
gtagggctag gcccaccg                                                     18


<210> 78
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 78
ctagtctttg ccgcctgcga agca                                              24


<210> 79
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 79
acaagctagt accagttgag ccagataag                                         29


<210> 80
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 80
gccgtgcgcg cttcagcaag c                                                 21


<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 81
cagtggcgcc cgaacaggga                                                   20


<210> 82
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 82
aactagggaa cccactgctt aag                                               23


<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 83
tccacagatc aaggatatct tgtc                                              24


<210> 84
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 84
acactacttg aagcactcaa ggcaagcttt                                        30


<210> 85
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 85
aactagggaa cccactgctt aag                                               23


<210> 86
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 86
tgctgggatt acaggcgtga g                                                 21


<210> 87
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 87
acactacttg aagcactcaa ggcaagcttt                                        30


<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 88
cggctaccac atccaaggaa                                                   20


<210> 89
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 89
gctggaatta ccgcggct                                                     18


<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 90
ccccgtgatg aagaagatga                                                   20


<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 91
gtcagcttgt gctggatgaa                                                   20


<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 92
ctgggttgat gtgacagtgg                                                   20


<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 93
tctgctgtct ttgggacctt                                                   20


<210> 94
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 94
acccactccc tcttagccaa tatt                                              24


<210> 95
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 95
gtagggctag gcccaccg                                                     18


<210> 96
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 96
ctagtctttg ccgcctgcga agca                                              24


<210> 97
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 97
acaagctagt accagttgag ccagataag                                         29


<210> 98
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 98
gccgtgcgcg cttcagcaag c                                                 21


<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 99
cagtggcgcc cgaacaggga                                                   20


<210> 100
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 100
ccctctagag ccaccatggc ttctggaatc ctggtta                                37


<210> 101
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 101
aaaaggatcc ttattcgagt tgtccacagt c                                      31


<210> 102
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 102
cggctgcagg ggtcagtgat ggtcaacccc accgtgttc                              39


<210> 103
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 103
gaacacggtg gggttgacca tcactgaccc ctgcagccg                              39


<210> 104
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 104
gctcctgatc tgaaaggaat ggtcaacccc accgtgttc                              39


<210> 105
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 105
gaacacggtg gggttgacca ttcctttcag atcaggagc                              39


<210> 106
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 106
ggtggggttg acccagtagc gtcggacatc tgtc                                   34


<210> 107
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 107
cgacgctact gggtcaaccc caccgtgttc                                        30


<210> 108
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 108
cgctactggg ttgatgtgac agtcaacccc accgtgttc                              39


<210> 109
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 109
gaacacggtg gggttgactg tcacatcaac ccagtagc                               38


<210> 110
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 110
gtggctccaa acaacatttc agtcaacccc accgtgttc                              39


<210> 111
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 111
gaacacggtg gggttgactg aaatgttgtt tggagccac                              39


<210> 112
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 112
tgggttgatg tgacagtggc tccaaacaac atttcatgtg ctgtcatttc gtcaacccca       60

ccgtg                                                                   65


<210> 113
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 113
gttgacagaa atgacagcac atgaaatgtt gtttggagcc actgtcacat caacccagta       60

gcgtcggac                                                               69


<210> 114
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 114
caagtgagct ctgtcaaccc caccgtgttc                                        30


<210> 115
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 115
ggggttgaca gagctcactt gtctcttatc ttcag                                  35


<210> 116
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 116
ccacagataa tatatggggc agtcaacccc accgtgttct tc                          42


<210> 117
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 117
cacggtgggg ttgactgccc catatattat ctgtggtttc g                           41


<210> 118
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 118
gctctcaaag tatcacatca ggggtcaacc ccaccgtgtt cttc                        44


<210> 119
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 119
gaagaacacg gtggggttga cccctgatgt gatactttga gagc                        44


<210> 120
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 120
gaggtagacg tgtccaagaa aactgtcaac cccaccgtgt tcttc                       45


<210> 121
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 121
gaagaacacg gtggggttga cagttttctt ggacacgtct acctc                       45


<210> 122
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 122
gaaaattatc aacctaaata cggcgtcaac cccaccgtgt tcttc                       45


<210> 123
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 123
gaagaacacg gtggggttga cgccgtattt aggttgataa ttttc                       45


<210> 124
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 124
ccctctagag ccaccatggc ttctggaatc ctgctta                                37


<210> 125
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 125
aaaagttaac tcaagagctt ggtgagcaca                                        30


<210> 126
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 126
ccctctagag ccaccatggc ttctggaatc ctggtta                                37


<210> 127
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 127
aaaagttaac tcaagagctt ggtgagcaca gagt                                   34


<210> 128
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(31)
<223> Any amino acid and this region may encompass 23-28 residues

<220>
<221> MOD_RES
<222> (34)..(37)
<223> Any amino acid and this region may encompass 2-4 residues

<400> 128
His Xaa Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro 
            20                  25                  30          


Cys Xaa Xaa Xaa Xaa Cys 
        35              


<210> 129
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 129
Arg Tyr Trp Asp Ala Ala Ala Trp Asp Leu Val Ala Ser Ala 
1               5                   10                  


<210> 130
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 130
Arg Tyr Trp Val Asp Val Thr Val Ala Pro Asn Asn Ile Ser Cys Ala 
1               5                   10                  15      


Val Ile Ser 
            


<210> 131
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 131
Arg Tyr Trp Gly Lys Glu Lys Ser His Tyr His Lys Pro Pro Cys Gly 
1               5                   10                  15      


Leu Ser 
        


<210> 132
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 132
Arg Tyr Trp Gly Trp Ser Ala Met Ala Arg Ser Arg Phe Thr Ala Thr 
1               5                   10                  15      


Ser Thr Ser 
            


<210> 133
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 133
Arg Tyr Trp Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210> 134
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 134
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Leu Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Pro Thr Glu Glu Val Ala Gln Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln Val 
305                 310                 315                 320 


Ser Ser Pro Lys Pro Gln Ile Ile Tyr Gly Ala Arg Gly Thr Arg Tyr 
                325                 330                 335     


Gln Thr Phe Val Asn Phe Asn Tyr Cys Thr Gly Ile Leu Gly Ser Gln 
            340                 345                 350         


Ser Ile Thr Ser Gly Lys His Tyr Trp Glu Val Asp Val Ser Lys Lys 
        355                 360                 365             


Thr Ala Trp Ile Leu Gly Val Cys Ala Gly Phe Gln Pro Asp Ala Met 
    370                 375                 380                 


Cys Asn Ile Glu Lys Asn Glu Asn Tyr Gln Pro Lys Tyr Gly Tyr Trp 
385                 390                 395                 400 


Val Ile Gly Leu Glu Glu Gly Val Lys Cys Ser Ala Phe Gln Asp Ser 
                405                 410                 415     


Ser Phe His Thr Pro Ser Val Pro Phe Ile Val Pro Leu Ser Val Ile 
            420                 425                 430         


Ile Cys Pro Asp Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Cys Thr 
        435                 440                 445             


Val Ser Phe Phe Asn Ile Thr Asn His Gly Phe Leu Ile Tyr Lys Phe 
    450                 455                 460                 


Ser His Cys Ser Phe Ser Gln Pro Val Phe Pro Tyr Leu Asn Pro Arg 
465                 470                 475                 480 


Lys Cys Gly Val Pro Met Thr Leu Cys Ser Pro Ser Ser 
                485                 490             


<210> 135
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 135
Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Gly 
            20          


<210> 136
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 136
Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Gly Trp Ser Ala Met Ala 
1               5                   10                  15      


Arg Ser Arg Phe Thr Ala Thr Ser Thr Ser 
            20                  25      


<210> 137
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 137
Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Gly Lys Glu Lys Ser His 
1               5                   10                  15      


Tyr His Lys Pro Pro Cys Gly Leu Ser 
            20                  25  


<210> 138
<211> 37
<212> PRT
<213> Macacca sp.

<400> 138
Phe Arg Asp Ala Ala Ala Glu Glu Ser Pro Val Leu Leu Ala Met Val 
1               5                   10                  15      


Asn Pro Thr Val Phe Phe Asp Ile Ala Asp Gly Glu Pro Leu Gly Arg 
            20                  25                  30          


Val Ser Phe Glu Leu 
        35          


<210> 139
<211> 45
<212> PRT
<213> Aotus sp.

<400> 139
Phe Lys Glu Pro Thr Glu Val Gln Arg Tyr Trp Asp Ala Ala Ala Trp 
1               5                   10                  15      


Asp Leu Val Ala Ser Ala Met Val Asn Pro Thr Val Phe Phe Asp Ile 
            20                  25                  30          


Ala Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu 
        35                  40                  45  


<210> 140
<211> 57
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Phe Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val 
1               5                   10                  15      


Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln 
            20                  25                  30          


Val Ser Ser Val Asn Pro Thr Val Phe Phe Asp Ile Ala Asp Gly Glu 
        35                  40                  45              


Pro Leu Gly Arg Val Ser Phe Glu Leu 
    50                  55          


<210> 141
<211> 56
<212> PRT
<213> Homo sapiens

<400> 141
Phe Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val 
1               5                   10                  15      


Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln 
            20                  25                  30          


Val Ser Ser Pro Lys Pro Gln Ile Ile Tyr Gly Ala Arg Gly Thr Arg 
        35                  40                  45              


Tyr Gln Thr Phe Val Asn Phe Asn 
    50                  55      


<210> 142
<211> 58
<212> PRT
<213> Macacca mulatta

<400> 142
Phe Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val 
1               5                   10                  15      


Ala Pro Asn Asn Ile Ser His Ala Val Ile Ala Glu Asp Lys Arg Gln 
            20                  25                  30          


Val Ser Ser Arg Asn Pro Gln Ile Met Tyr Gln Ala Pro Gly Thr Leu 
        35                  40                  45              


Phe Thr Phe Pro Ser Leu Thr Asn Phe Asn 
    50                  55              


<210> 143
<211> 56
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Phe Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val 
1               5                   10                  15      


Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln 
            20                  25                  30          


Val Ser Ser Arg Lys Pro Gln Ile Ile Tyr Gly Ala Pro Gly Thr Arg 
        35                  40                  45              


Tyr Gln Thr Phe Val Asn Phe Asn 
    50                  55      


<210> 144
<211> 56
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Phe Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val 
1               5                   10                  15      


Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln 
            20                  25                  30          


Val Ser Ser Arg Asn Pro Gln Ile Met Tyr Gln Ala Pro Gly Thr Arg 
        35                  40                  45              


Tyr Gln Thr Phe Val Asn Phe Asn 
    50                  55      


<210> 145
<211> 485
<212> PRT
<213> Homo sapiens

<400> 145
Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro 
    50                  55                  60                  


Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu 
65                  70                  75                  80  


Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala 
                85                  90                  95      


Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val 
            100                 105                 110         


Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr 
        115                 120                 125             


Phe Leu Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala 
    130                 135                 140                 


Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu 
145                 150                 155                 160 


Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr 
                165                 170                 175     


Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu 
            180                 185                 190         


Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu 
        195                 200                 205             


Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln 
    210                 215                 220                 


Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln 
225                 230                 235                 240 


Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys Arg 
                245                 250                 255     


Thr Glu Asn Val Thr Leu Lys Lys Pro Glu Thr Phe Pro Lys Asn Gln 
            260                 265                 270         


Arg Arg Val Phe Arg Ala Pro Asp Leu Lys Gly Met Leu Glu Val Phe 
        275                 280                 285             


Arg Glu Leu Thr Asp Val Arg Arg Tyr Trp Val Asp Val Thr Val Ala 
    290                 295                 300                 


Pro Asn Asn Ile Ser Cys Ala Val Ile Ser Glu Asp Lys Arg Gln Val 
305                 310                 315                 320 


Ser Ser Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu 
                325                 330                 335     


Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys 
            340                 345                 350         


Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly 
        355                 360                 365             


Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln 
    370                 375                 380                 


Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr 
385                 390                 395                 400 


Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro 
                405                 410                 415     


Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln 
            420                 425                 430         


Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val 
        435                 440                 445             


Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu 
    450                 455                 460                 


Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala 
465                 470                 475                 480 


Asp Cys Gly Gln Leu 
                485 


<210> 146
<211> 474
<212> PRT
<213> Aotus sp.

<400> 146
Met Ala Ser Arg Ile Leu Val Asn Ile Lys Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Ile Thr Ala Asn His Lys Lys Ser Met Pro 
        35                  40                  45              


His Gln Gly Glu Arg Ser Cys Pro Leu Cys Arg Ile Ser Tyr Ser Ser 
    50                  55                  60                  


Glu Asn Leu Arg Pro Asn Arg His Leu Val Asn Ile Val Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Val Met Leu Ser Pro Glu Glu Gly Gln Lys Val Asp His Cys 
                85                  90                  95      


Ala His His Gly Glu Lys Leu Val Leu Phe Cys Gln Gln Asp Gly Asn 
            100                 105                 110         


Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His Gln 
        115                 120                 125             


Thr Phe Leu Val Glu Glu Val Ala Gln Lys Tyr Arg Glu Lys Leu Gln 
    130                 135                 140                 


Val Ala Leu Glu Met Met Arg Gln Lys Gln Lys Asp Ala Glu Lys Leu 
145                 150                 155                 160 


Glu Ala Asp Val Arg Glu Glu Gln Ala Ser Trp Lys Ile Gln Ile Gln 
                165                 170                 175     


Asn Asp Lys Thr Asn Ile Met Ala Glu Phe Lys Lys Arg Arg Asp Ile 
            180                 185                 190         


Leu Asp Cys Glu Glu Ser Lys Glu Leu Gln Asn Leu Glu Lys Glu Glu 
        195                 200                 205             


Lys Asn Ile Leu Lys Arg Leu Val Gln Ser Glu Asn Asp Met Val Leu 
    210                 215                 220                 


Gln Thr Gln Ser Val Arg Val Leu Ile Ser Asp Leu Glu His Arg Leu 
225                 230                 235                 240 


Gln Gly Ser Val Met Glu Leu Leu Gln Gly Val Asp Gly Val Ile Lys 
                245                 250                 255     


Arg Ile Glu Lys Val Thr Leu Gln Asn Pro Lys Thr Phe Leu Asn Glu 
            260                 265                 270         


Lys Arg Arg Ile Phe Gln Thr Pro Asp Leu Lys Gly Thr Leu Gln Val 
        275                 280                 285             


Phe Lys Glu Pro Thr Glu Val Gln Arg Tyr Trp Asp Ala Ala Ala Trp 
    290                 295                 300                 


Asp Leu Val Ala Ser Ala Met Val Asn Pro Thr Val Phe Phe Asp Ile 
305                 310                 315                 320 


Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala 
                325                 330                 335     


Asp Lys Val Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly 
            340                 345                 350         


Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro 
        355                 360                 365             


Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly 
    370                 375                 380                 


Gly Lys Ser Ile Tyr Gly Glu Lys Phe Asp Asp Glu Asn Phe Ile Leu 
385                 390                 395                 400 


Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn 
                405                 410                 415     


Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu 
            420                 425                 430         


Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Val 
        435                 440                 445             


Val Glu Ala Met Glu Arg Phe Gly Cys Arg Tyr Gly Lys Thr Ser Lys 
    450                 455                 460                 


Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu 
465                 470                 


<210> 147
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 147
Val Asp Val Thr Val Ala Pro Asn Asn Ile Ser Cys Ala Val Ile Ser 
1               5                   10                  15      


<210> 148
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 148
Gly Lys Glu Lys Ser His Tyr His Lys Pro Pro Cys Gly Leu Ser 
1               5                   10                  15  


<210> 149
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 149
Gly Trp Ser Ala Met Ala Arg Ser Arg Phe Thr Ala Thr Ser Thr Ser 
1               5                   10                  15      



