                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  Compositions and Methods of Use for Thrombomodulin Variants

<130>  X-18065

<150>  61/113801
<151>  2008-11-12

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  575
<212>  PRT
<213>  HOMO SAPIENS

<400>  1

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Ile Trp Glu Glu Gln Gln Cys Glu Val Lys 
145                 150                 155                 160 


Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg Pro 
                165                 170                 175     


Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr Tyr 
            180                 185                 190         


Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro Val 
        195                 200                 205             


Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys Thr 
    210                 215                 220                 


Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro Gly 
225                 230                 235                 240 


Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys Asn 
                245                 250                 255     


Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu 
            260                 265                 270         


Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn 
        275                 280                 285             


Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly Ser 
    290                 295                 300                 


Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln His 
305                 310                 315                 320 


Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro 
                325                 330                 335     


Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr Pro 
            340                 345                 350         


Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro Cys 
        355                 360                 365             


Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser 
    370                 375                 380                 


Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro 
385                 390                 395                 400 


His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys 
                405                 410                 415     


Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu 
            420                 425                 430         


Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Asn Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Val Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
        515                 520                 525             


Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
    530                 535                 540                 


Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
545                 550                 555                 560 


Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                565                 570                 575 


<210>  2
<211>  515
<212>  PRT
<213>  HOMO SAPIENS

<400>  2

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser 
        515 


<210>  3
<211>  484
<212>  PRT
<213>  HOMO SAPIENS

<400>  3

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys 
                


<210>  4
<211>  497
<212>  PRT
<213>  HOMO SAPIENS

<400>  4

Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu His Asp 
1               5                   10                  15      


Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala Ser Gln 
            20                  25                  30          


Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser Ser Val 
        35                  40                  45              


Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly Val Gly 
    50                  55                  60                  


Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys Gly Asp 
65                  70                  75                  80  


Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
                85                  90                  95      


Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn Gly Ala 
            100                 105                 110         


Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu Ala Thr 
        115                 120                 125             


Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val Lys Ala 
    130                 135                 140                 


Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg Pro Leu 
145                 150                 155                 160 


Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr Tyr Gly 
                165                 170                 175     


Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro Val Gly 
            180                 185                 190         


Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys Thr Ala 
        195                 200                 205             


Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro Gly Ala 
    210                 215                 220                 


Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys Asn Ala 
225                 230                 235                 240 


Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu Gln 
                245                 250                 255     


Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn Asp 
            260                 265                 270         


Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly Ser Tyr 
        275                 280                 285             


Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln His Arg 
    290                 295                 300                 


Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro Gln 
305                 310                 315                 320 


Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr Pro Asn 
                325                 330                 335     


Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro Cys Phe 
            340                 345                 350         


Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr 
        355                 360                 365             


Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His 
    370                 375                 380                 


Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp 
385                 390                 395                 400 


Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp 
                405                 410                 415     


Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe 
            420                 425                 430         


Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys 
        435                 440                 445             


Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser 
    450                 455                 460                 


Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro Pro Ser 
465                 470                 475                 480 


Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu Val His 
                485                 490                 495     


Ser 
    


<210>  5
<211>  466
<212>  PRT
<213>  HOMO SAPIENS

<400>  5

Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu His Asp 
1               5                   10                  15      


Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala Ser Gln 
            20                  25                  30          


Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser Ser Val 
        35                  40                  45              


Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly Val Gly 
    50                  55                  60                  


Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys Gly Asp 
65                  70                  75                  80  


Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
                85                  90                  95      


Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn Gly Ala 
            100                 105                 110         


Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu Ala Thr 
        115                 120                 125             


Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val Lys Ala 
    130                 135                 140                 


Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg Pro Leu 
145                 150                 155                 160 


Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr Tyr Gly 
                165                 170                 175     


Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro Val Gly 
            180                 185                 190         


Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys Thr Ala 
        195                 200                 205             


Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro Gly Ala 
    210                 215                 220                 


Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys Asn Ala 
225                 230                 235                 240 


Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu Gln 
                245                 250                 255     


Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn Asp 
            260                 265                 270         


Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly Ser Tyr 
        275                 280                 285             


Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln His Arg 
    290                 295                 300                 


Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro Gln 
305                 310                 315                 320 


Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr Pro Asn 
                325                 330                 335     


Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro Cys Phe 
            340                 345                 350         


Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr 
        355                 360                 365             


Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His 
    370                 375                 380                 


Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp 
385                 390                 395                 400 


Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp 
                405                 410                 415     


Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe 
            420                 425                 430         


Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys 
        435                 440                 445             


Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser 
    450                 455                 460                 


Gly Lys 
465     


<210>  6
<211>  466
<212>  PRT
<213>  HOMO SAPIENS

<400>  6

Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu His Asp 
1               5                   10                  15      


Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala Ser Gln 
            20                  25                  30          


Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser Ser Val 
        35                  40                  45              


Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly Val Gly 
    50                  55                  60                  


Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys Gly Asp 
65                  70                  75                  80  


Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
                85                  90                  95      


Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn Gly Ala 
            100                 105                 110         


Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu Ala Thr 
        115                 120                 125             


Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val Lys Ala 
    130                 135                 140                 


Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg Pro Leu 
145                 150                 155                 160 


Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr Tyr Gly 
                165                 170                 175     


Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro Val Gly 
            180                 185                 190         


Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys Thr Ala 
        195                 200                 205             


Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro Gly Ala 
    210                 215                 220                 


Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys Asn Ala 
225                 230                 235                 240 


Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu Gln 
                245                 250                 255     


Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn Asp 
            260                 265                 270         


Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly Ser Tyr 
        275                 280                 285             


Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln His Arg 
    290                 295                 300                 


Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro Gln 
305                 310                 315                 320 


Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr Pro Asn 
                325                 330                 335     


Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro Cys Phe 
            340                 345                 350         


Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr 
        355                 360                 365             


Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His 
    370                 375                 380                 


Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp 
385                 390                 395                 400 


Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp 
                405                 410                 415     


Asp Gly Phe Ile Cys Thr Asp Ala Asp Glu Cys Glu Asn Gly Gly Phe 
            420                 425                 430         


Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys 
        435                 440                 445             


Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser 
    450                 455                 460                 


Gly Lys 
465     


<210>  7
<211>  1398
<212>  DNA
<213>  HOMO SAPIENS

<400>  7
gcccctgccg agcctcagcc tggcggcagc cagtgcgtgg agcacgactg cttcgccctg       60

taccccggac ccgccacctt cctgaacgcc agccagatct gcgacggcct gcggggccac      120

ctgatgaccg tgcggagcag cgtggccgcc gacgtgatca gcctgctgct gaacggcgac      180

ggcggcgtgg gcaggcggag gctgtggatc ggactgcagc tgccccctgg ctgcggcgac      240

cccaagaggc tgggccccct gcggggcttc cagtgggtga ccggcgacaa caacaccagc      300

tacagcagat gggccaggct ggacctgaat ggcgcccctc tgtgcggccc actgtgcgtg      360

gccgtgtctg ccgccgaggc caccgtgccc agcgagccca tctgggagga acagcagtgc      420

gaagtgaagg ccgacggctt cctgtgcgag ttccacttcc ccgccacctg caggcctctg      480

gccgtggaac ctggagccgc tgctgccgcc gtgagcatca cctacggcac ccccttcgcc      540

gccagaggcg ccgacttcca ggccctgccc gtgggctctt ctgccgccgt ggcccccctg      600

gggctgcagc tgatgtgcac cgcccctcca ggcgccgtgc agggccactg ggccagagaa      660

gcccctggcg cctgggactg cagcgtggag aacggcggct gcgagcacgc ctgcaacgcc      720

atccctggcg cccctaggtg ccagtgccct gccggagccg ccctccaggc cgatggcaga      780

agctgcaccg ccagcgccac ccagagctgc aacgacctgt gcgagcactt ctgcgtgccc      840

aaccccgacc agcccggcag ctacagctgc atgtgcgaga ccggctaccg gctggccgcc      900

gatcagcaca gatgcgagga cgtggacgac tgcatcctgg aacccagccc ctgcccccag      960

agatgcgtga acacccaggg cggcttcgag tgccactgct accccaacta cgacctggtg     1020

gacggcgagt gtgtggagcc cgtggacccc tgcttccggg ccaactgcga gtaccagtgc     1080

cagcccctga accagaccag ctacctgtgc gtgtgcgccg aaggcttcgc ccccatcccc     1140

cacgagcccc accggtgcca gatgttctgc aaccagaccg cctgccctgc cgactgcgac     1200

cccaataccc aggccagctg cgagtgcccc gagggctaca tcctggacga cggcttcatc     1260

tgcaccgaca tcgacgagtg cgagaatggc ggcttctgca gcggcgtgtg ccacaacctg     1320

cccggcacct tcgagtgcat ctgcggccct gacagcgccc tggcccggca catcggcacc     1380

gactgcgata gcggcaag                                                   1398


<210>  8
<211>  1398
<212>  DNA
<213>  HOMO SAPIENS

<400>  8
gcccctgccg agcctcagcc tggcggcagc cagtgcgtgg agcacgactg cttcgccctg       60

taccccggac ccgccacctt cctgaacgcc agccagatct gcgacggcct gcggggccac      120

ctgatgaccg tgcggagcag cgtggccgcc gacgtgatca gcctgctgct gaacggcgac      180

ggcggcgtgg gcaggcggag gctgtggatc ggactgcagc tgccccctgg ctgcggcgac      240

cccaagaggc tgggccccct gcggggcttc cagtgggtga ccggcgacaa caacaccagc      300

tacagcagat gggccaggct ggacctgaat ggcgcccctc tgtgcggccc actgtgcgtg      360

gccgtgtctg ccgccgaggc caccgtgccc agcgagccca tctgggagga acagcagtgc      420

gaagtgaagg ccgacggctt cctgtgcgag ttccacttcc ccgccacctg caggcctctg      480

gccgtggaac ctggagccgc tgctgccgcc gtgagcatca cctacggcac ccccttcgcc      540

gccagaggcg ccgacttcca ggccctgccc gtgggctctt ctgccgccgt ggcccccctg      600

gggctgcagc tgatgtgcac cgcccctcca ggcgccgtgc agggccactg ggccagagaa      660

gcccctggcg cctgggactg cagcgtggag aacggcggct gcgagcacgc ctgcaacgcc      720

atccctggcg cccctaggtg ccagtgccct gccggagccg ccctccaggc cgatggcaga      780

agctgcaccg ccagcgccac ccagagctgc aacgacctgt gcgagcactt ctgcgtgccc      840

aaccccgacc agcccggcag ctacagctgc atgtgcgaga ccggctaccg gctggccgcc      900

gatcagcaca gatgcgagga cgtggacgac tgcatcctgg aacccagccc ctgcccccag      960

agatgcgtga acacccaggg cggcttcgag tgccactgct accccaacta cgacctggtg     1020

gacggcgagt gtgtggagcc cgtggacccc tgcttccggg ccaactgcga gtaccagtgc     1080

cagcccctga accagaccag ctacctgtgc gtgtgcgccg aaggcttcgc ccccatcccc     1140

cacgagcccc accggtgcca gatgttctgc aaccagaccg cctgccctgc cgactgcgac     1200

cccaataccc aggccagctg cgagtgcccc gagggctaca tcctggacga cggcttcatc     1260

tgcaccgacg ccgacgagtg cgagaatggc ggcttctgca gcggcgtgtg ccacaacctg     1320

cccggcacct tcgagtgcat ctgcggccct gacagcgccc tggcccggca catcggcacc     1380

gactgcgata gcggcaag                                                   1398


<210>  9
<211>  1545
<212>  DNA
<213>  HOMO SAPIENS

<400>  9
atgctgggcg tgctggtgct gggagccctg gccctggccg gcctgggctt tcctgcccct       60

gccgagcctc agcctggcgg cagccagtgc gtggagcacg actgcttcgc cctgtacccc      120

ggacccgcca ccttcctgaa cgccagccag atctgcgacg gcctgcgggg ccacctgatg      180

accgtgcgga gcagcgtggc cgccgacgtg atcagcctgc tgctgaacgg cgacggcggc      240

gtgggcaggc ggaggctgtg gatcggactg cagctgcccc ctggctgcgg cgaccccaag      300

aggctgggcc ccctgcgggg cttccagtgg gtgaccggcg acaacaacac cagctacagc      360

agatgggcca ggctggacct gaatggcgcc cctctgtgcg gcccactgtg cgtggccgtg      420

tctgccgccg aggccaccgt gcccagcgag cccatctggg aggaacagca gtgcgaagtg      480

aaggccgacg gcttcctgtg cgagttccac ttccccgcca cctgcaggcc tctggccgtg      540

gaacctggag ccgctgctgc cgccgtgagc atcacctacg gcaccccctt cgccgccaga      600

ggcgccgact tccaggccct gcccgtgggc tcttctgccg ccgtggcccc cctggggctg      660

cagctgatgt gcaccgcccc tccaggcgcc gtgcagggcc actgggccag agaagcccct      720

ggcgcctggg actgcagcgt ggagaacggc ggctgcgagc acgcctgcaa cgccatccct      780

ggcgccccta ggtgccagtg ccctgccgga gccgccctcc aggccgatgg cagaagctgc      840

accgccagcg ccacccagag ctgcaacgac ctgtgcgagc acttctgcgt gcccaacccc      900

gaccagcccg gcagctacag ctgcatgtgc gagaccggct accggctggc cgccgatcag      960

cacagatgcg aggacgtgga cgactgcatc ctggaaccca gcccctgccc ccagagatgc     1020

gtgaacaccc agggcggctt cgagtgccac tgctacccca actacgacct ggtggacggc     1080

gagtgtgtgg agcccgtgga cccctgcttc cgggccaact gcgagtacca gtgccagccc     1140

ctgaaccaga ccagctacct gtgcgtgtgc gccgaaggct tcgcccccat cccccacgag     1200

ccccaccggt gccagatgtt ctgcaaccag accgcctgcc ctgccgactg cgaccccaat     1260

acccaggcca gctgcgagtg ccccgagggc tacatcctgg acgacggctt catctgcacc     1320

gacatcgacg agtgcgagaa tggcggcttc tgcagcggcg tgtgccacaa cctgcccggc     1380

accttcgagt gcatctgcgg ccctgacagc gccctggccc ggcacatcgg caccgactgc     1440

gatagcggca aggtggacgg gggcgactcc ggctccggcg agccccctcc cagccctacc     1500

cccggcagca ccctgacccc tcccgccgtg ggcctggtgc acagc                     1545


<210>  10
<211>  1545
<212>  DNA
<213>  HOMO SAPIENS

<400>  10
atgctgggcg tgctggtgct gggagccctg gccctcgctg gactgggctt tcctgcccct       60

gccgagcctc agcctggcgg cagccagtgc gtggagcacg actgcttcgc cctgtacccc      120

ggacccgcca ccttcctgaa cgccagccag atctgcgacg gcctgagagg ccacctgatg      180

accgtgcgga gcagcgtggc cgccgacgtg atcagcctgc tgctgaacgg cgacggcggc      240

gtgggcaggc ggagactgtg gatcggcctg cagctgcccc ctggctgcgg cgaccccaag      300

agactgggcc ccctgcgggg cttccagtgg gtgaccggcg acaacaacac cagctacagc      360

agatgggcca gactggacct gaatggcgcc cctctgtgcg gcccactgtg cgtggccgtg      420

tctgctgccg aggccaccgt gcccagcgag cccatctggg aggaacagca gtgcgaagtg      480

aaggccgacg gcttcctgtg cgagttccac ttccccgcca cctgcagacc cctggccgtg      540

gaacccggcg ccgctgctgc agccgtgtct atcacctacg gcaccccctt cgccgccaga      600

ggcgccgact tccaggccct gcccgtggga agctctgccg ccgtggcccc tctggggctg      660

cagctgatgt gcaccgcccc tccaggcgcc gtgcagggcc actgggccag agaagcccct      720

ggggcctggg actgcagcgt ggagaacggc ggctgcgagc acgcctgcaa cgccatccct      780

ggcgccccta gatgccagtg ccctgctgga gccgccctgc aggccgatgg cagaagctgc      840

accgccagcg ccacccagag ctgcaacgac ctgtgcgagc acttctgcgt gcccaacccc      900

gaccagcctg gaagctacag ctgcatgtgc gagacaggct accggctggc cgccgatcag      960

cacagatgcg aggacgtgga cgactgcatc ctggaaccca gcccctgccc ccagagatgc     1020

gtgaacaccc agggcggctt cgagtgccac tgctacccta actacgacct ggtggacggc     1080

gagtgtgtgg agcccgtgga cccctgcttc cgggccaact gcgagtacca gtgccagccc     1140

ctgaaccaga ccagctacct gtgcgtgtgc gccgaaggct tcgcccccat cccccacgag     1200

ccccaccggt gccagatgtt ctgcaaccag accgcctgtc ctgccgactg cgaccccaat     1260

acccaggcca gctgtgagtg ccccgagggc tacatcctgg acgacggctt catctgcaca     1320

gacgccgacg agtgcgagaa tggcggcttc tgcagcggcg tgtgccacaa cctgcccggc     1380

accttcgagt gcatctgcgg ccctgacagc gccctggcca gacacatcgg caccgactgc     1440

gatagcggca aggtggacgg gggggacgcc ggagccggcg agcctccccc cagccctacc     1500

cccggcagca ccctgacccc tcccgccgtg ggcctggtgc acagc                     1545


<210>  11
<211>  426
<212>  PRT
<213>  HOMO SAPIENS

<400>  11

Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu His Asp 
1               5                   10                  15      


Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala Ser Gln 
            20                  25                  30          


Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser Ser Val 
        35                  40                  45              


Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly Val Gly 
    50                  55                  60                  


Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys Gly Asp 
65                  70                  75                  80  


Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
                85                  90                  95      


Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn Gly Ala 
            100                 105                 110         


Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu Ala Thr 
        115                 120                 125             


Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val Lys Ala 
    130                 135                 140                 


Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg Pro Leu 
145                 150                 155                 160 


Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr Tyr Gly 
                165                 170                 175     


Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro Val Gly 
            180                 185                 190         


Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys Thr Ala 
        195                 200                 205             


Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro Gly Ala 
    210                 215                 220                 


Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys Asn Ala 
225                 230                 235                 240 


Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu Gln 
                245                 250                 255     


Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn Asp 
            260                 265                 270         


Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly Ser Tyr 
        275                 280                 285             


Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln His Arg 
    290                 295                 300                 


Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro Gln 
305                 310                 315                 320 


Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr Pro Asn 
                325                 330                 335     


Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro Cys Phe 
            340                 345                 350         


Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr 
        355                 360                 365             


Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu Pro His 
    370                 375                 380                 


Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp 
385                 390                 395                 400 


Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp 
                405                 410                 415     


Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu 
            420                 425     


<210>  12
<211>  1278
<212>  DNA
<213>  HOMO SAPIENS

<400>  12
gcccctgccg agcctcagcc tggcggcagc cagtgcgtgg agcacgactg cttcgccctg       60

taccccggac ccgccacctt cctgaacgcc agccagatct gcgacggcct gcggggccac      120

ctgatgaccg tgcggagcag cgtggccgcc gacgtgatca gcctgctgct gaacggcgac      180

ggcggcgtgg gcaggcggag gctgtggatc ggactgcagc tgccccctgg ctgcggcgac      240

cccaagaggc tgggccccct gcggggcttc cagtgggtga ccggcgacaa caacaccagc      300

tacagcagat gggccaggct ggacctgaat ggcgcccctc tgtgcggccc actgtgcgtg      360

gccgtgtctg ccgccgaggc caccgtgccc agcgagccca tctgggagga acagcagtgc      420

gaagtgaagg ccgacggctt cctgtgcgag ttccacttcc ccgccacctg caggcctctg      480

gccgtggaac ctggagccgc tgctgccgcc gtgagcatca cctacggcac ccccttcgcc      540

gccagaggcg ccgacttcca ggccctgccc gtgggctctt ctgccgccgt ggcccccctg      600

gggctgcagc tgatgtgcac cgcccctcca ggcgccgtgc agggccactg ggccagagaa      660

gcccctggcg cctgggactg cagcgtggag aacggcggct gcgagcacgc ctgcaacgcc      720

atccctggcg cccctaggtg ccagtgccct gccggagccg ccctccaggc cgatggcaga      780

agctgcaccg ccagcgccac ccagagctgc aacgacctgt gcgagcactt ctgcgtgccc      840

aaccccgacc agcccggcag ctacagctgc atgtgcgaga ccggctaccg gctggccgcc      900

gatcagcaca gatgcgagga cgtggacgac tgcatcctgg aacccagccc ctgcccccag      960

agatgcgtga acacccaggg cggcttcgag tgccactgct accccaacta cgacctggtg     1020

gacggcgagt gtgtggagcc cgtggacccc tgcttccggg ccaactgcga gtaccagtgc     1080

cagcccctga accagaccag ctacctgtgc gtgtgcgccg aaggcttcgc ccccatcccc     1140

cacgagcccc accggtgcca gatgttctgc aaccagaccg cctgccctgc cgactgcgac     1200

cccaataccc aggccagctg cgagtgcccc gagggctaca tcctggacga cggcttcatc     1260

tgcaccgaca tcgacgag                                                   1278


<210>  13
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro 
        


