                               SEQUENCE LISTING                               

<110> GEORGIOU, GEORGE
      SEGATORI, LAURA

<120> ARTIFICIAL DISULFIDE ISOMERASES AND USES THEREOF

<130> UTFB:730WO

<140> UNKNOWN
<141> 2007-04-05

<150> 60/790,522
<151> 2006-04-07

<160> 45                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 270
<212> PRT
<213> Escherichia coli

<400> 1
Met Lys Ser Leu Phe Lys Val Thr Leu Leu Ala Thr Thr Met Ala Val  
  1               5                  10                  15    

Ala Leu His Ala Pro Ile Thr Phe Ala Ala Glu Ala Ala Lys Pro Ala  
             20                  25                  30        

Thr Ala Ala Asp Ser Lys Ala Ala Phe Lys Asn Asp Asp Gln Lys Ser  
         35                  40                  45            

Ala Tyr Ala Leu Gly Ala Ser Leu Gly Arg Tyr Met Glu Asn Ser Leu  
     50                  55                  60                

Lys Glu Gln Glu Lys Leu Gly Ile Lys Leu Asp Lys Asp Gln Leu Ile  
 65                  70                  75                  80

Ala Gly Val Gln Asp Ala Phe Ala Asp Lys Ser Lys Leu Ser Asp Gln  
                 85                  90                  95    

Glu Ile Glu Gln Thr Leu Gln Ala Phe Glu Ala Arg Val Lys Ser Ser  
            100                 105                 110        

Ala Gln Ala Lys Met Glu Lys Asp Ala Ala Asp Asn Glu Ala Lys Gly  
        115                 120                 125            

Lys Glu Tyr Arg Glu Lys Phe Ala Lys Glu Lys Gly Val Lys Thr Ser  
    130                 135                 140                

Ser Thr Gly Leu Val Tyr Gln Val Val Glu Ala Gly Lys Gly Glu Ala  
145                 150                 155                 160

Pro Lys Asp Ser Asp Thr Val Val Val Asn Tyr Lys Gly Thr Leu Ile  
                165                 170                 175    

Asp Gly Lys Glu Phe Asp Asn Ser Tyr Thr Arg Gly Glu Pro Leu Ser  
            180                 185                 190        

Phe Arg Leu Asp Gly Val Ile Pro Gly Trp Thr Glu Gly Leu Lys Asn  
        195                 200                 205            

Ile Lys Lys Gly Gly Lys Ile Lys Leu Val Ile Pro Pro Glu Leu Ala  
    210                 215                 220                

Tyr Gly Lys Ala Gly Val Pro Gly Ile Pro Pro Asn Ser Thr Leu Val  
225                 230                 235                 240

Phe Asp Val Glu Leu Leu Asp Val Lys Pro Ala Pro Lys Ala Asp Ala  
                245                 250                 255    

Lys Pro Glu Ala Asp Ala Lys Ala Ala Asp Ser Ala Lys Lys          
            260                 265                 270


<210> 2
<211> 114
<212> PRT
<213> Escherichia coli

<400> 2
Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly  
  1               5                  10                  15    

Phe Ala Gln Ala Gln Lys Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly  
             20                  25                  30        

Arg Tyr Met Glu Asn Ser Leu Lys Glu Gln Glu Lys Leu Gly Ile Lys  
         35                  40                  45            

Leu Asp Lys Asp Gln Leu Ile Ala Gly Val Gln Asp Ala Phe Ala Asp  
     50                  55                  60                

Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr Leu Gln Ala Phe  
 65                  70                  75                  80

Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met Glu Lys Asp Ala  
                 85                  90                  95    

Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu Lys Phe Ala Lys  
            100                 105                 110        

Glu Lys                                                          
       


<210> 3
<211> 189
<212> PRT
<213> Escherichia coli

<400> 3
Ala Gln Tyr Glu Asp Gly Lys Gln Tyr Thr Thr Leu Glu Lys Pro Val  
  1               5                  10                  15    

Ala Gly Ala Pro Gln Val Leu Glu Phe Phe Ser Phe Phe Cys Pro His  
             20                  25                  30        

Cys Tyr Gln Phe Glu Glu Val Leu His Ile Ser Asp Asn Val Lys Lys  
         35                  40                  45            

Lys Leu Pro Glu Gly Val Lys Met Thr Lys Tyr His Val Asn Phe Met  
     50                  55                  60                

Gly Gly Asp Leu Gly Lys Asp Leu Thr Gln Ala Trp Ala Val Ala Met  
 65                  70                  75                  80

Ala Leu Gly Val Glu Asp Lys Val Thr Val Pro Leu Phe Glu Gly Val  
                 85                  90                  95    

Gln Lys Thr Gln Thr Ile Arg Ser Ala Ser Asp Ile Arg Asp Val Phe  
            100                 105                 110        

Ile Asn Ala Gly Ile Lys Gly Glu Glu Tyr Asp Ala Ala Trp Asn Ser  
        115                 120                 125            

Phe Val Val Lys Ser Leu Val Ala Gln Gln Glu Lys Ala Ala Ala Asp  
    130                 135                 140                

Val Gln Leu Arg Gly Val Pro Ala Met Phe Val Asn Gly Lys Tyr Gln  
145                 150                 155                 160

Leu Asn Pro Gln Gly Met Asp Thr Ser Asn Met Asp Val Phe Val Gln  
                165                 170                 175    

Gln Tyr Ala Asp Thr Val Lys Tyr Leu Ser Glu Lys Lys              
            180                 185                


<210> 4
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Peptide

<400> 4
Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly  
  1               5                  10                  15    

Phe Ala Gln Ala Gln Lys Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly  
             20                  25                  30        

Arg Tyr Met Glu Asn Ser Leu Lys Glu Gln Glu Lys Leu Gly Ile Lys  
         35                  40                  45            

Leu Asp Lys Asp Gln Leu Ile Ala Gly Val Gln Asp Ala Phe Ala Asp  
     50                  55                  60                

Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr Leu Gln Ala Phe  
 65                  70                  75                  80

Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met Glu Lys Asp Ala  
                 85                  90                  95    

Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu Lys Phe Ala Lys  
            100                 105                 110        

Glu Lys Ala Gln Tyr Glu Asp Gly Lys Gln Tyr Thr Thr Leu Glu Lys  
        115                 120                 125            

Pro Val Ala Gly Ala Pro Gln Val Leu Glu Phe Phe Ser Phe Phe Cys  
    130                 135                 140                

Pro His Cys Tyr Gln Phe Glu Glu Val Leu His Ile Ser Asp Asn Val  
145                 150                 155                 160

Lys Lys Lys Leu Pro Glu Gly Val Lys Met Thr Lys Tyr His Val Asn  
                165                 170                 175    

Phe Met Gly Gly Asp Leu Gly Lys Asp Leu Thr Gln Ala Trp Ala Val  
            180                 185                 190        

Ala Met Ala Leu Gly Val Glu Asp Lys Val Thr Val Pro Leu Phe Glu  
        195                 200                 205            

Gly Val Gln Lys Thr Gln Thr Ile Arg Ser Ala Ser Asp Ile Arg Asp  
    210                 215                 220                

Val Phe Ile Asn Ala Gly Ile Lys Gly Glu Glu Tyr Asp Ala Ala Trp  
225                 230                 235                 240

Asn Ser Phe Val Val Lys Ser Leu Val Ala Gln Gln Glu Lys Ala Ala  
                245                 250                 255    

Ala Asp Val Gln Leu Arg Gly Val Pro Ala Met Phe Val Asn Gly Lys  
            260                 265                 270        

Tyr Gln Leu Asn Pro Gln Gly Met Asp Thr Ser Asn Met Asp Val Phe  
        275                 280                 285            

Val Gln Gln Tyr Ala Asp Thr Val Lys Tyr Leu Ser Glu Lys Lys His  
    290                 295                 300                

His His His His His                                              
305                


<210> 5
<211> 308
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Peptide

<400> 5
Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly  
  1               5                  10                  15    

Phe Ala Gln Ala Gln Lys Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly  
             20                  25                  30        

Arg Tyr Met Glu Asn Ser Leu Lys Glu Gln Glu Lys Leu Gly Ile Lys  
         35                  40                  45            

Leu Asp Lys Asp Gln Leu Ile Ala Gly Val Gln Asp Ala Phe Ala Asp  
     50                  55                  60                

Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr Leu Gln Ala Phe  
 65                  70                  75                  80

Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met Glu Lys Asp Ala  
                 85                  90                  95    

Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu Lys Phe Ala Lys  
            100                 105                 110        

Glu Lys Gln Tyr Glu Asp Gly Lys Gln Tyr Thr Thr Leu Glu Lys Pro  
        115                 120                 125            

Val Ala Gly Ala Pro Gln Val Leu Glu Phe Phe Ser Phe Phe Cys Pro  
    130                 135                 140                

His Cys Tyr Gln Phe Glu Glu Val Leu His Ile Ser Asp Asn Val Lys  
145                 150                 155                 160

Lys Lys Leu Pro Glu Gly Val Lys Met Thr Lys Tyr His Val Asn Phe  
                165                 170                 175    

Met Gly Gly Asp Leu Gly Lys Asp Leu Thr Gln Ala Trp Ala Val Ala  
            180                 185                 190        

Met Ala Leu Gly Val Glu Asp Lys Val Thr Val Pro Leu Phe Glu Gly  
        195                 200                 205            

Val Gln Lys Thr Gln Thr Ile Arg Ser Ala Ser Asp Ile Arg Asp Val  
    210                 215                 220                

Phe Ile Asn Ala Gly Ile Lys Gly Glu Glu Tyr Asp Ala Ala Trp Asn  
225                 230                 235                 240

Ser Phe Val Val Lys Ser Leu Val Ala Gln Gln Glu Lys Ala Ala Ala  
                245                 250                 255    

Asp Val Gln Leu Arg Gly Val Pro Ala Met Phe Val Asn Gly Lys Tyr  
            260                 265                 270        

Gln Leu Asn Pro Gln Gly Met Asp Thr Ser Asn Met Asp Val Phe Val  
        275                 280                 285            

Gln Gln Tyr Ala Asp Thr Val Lys Tyr Leu Ser Glu Lys Lys His His  
    290                 295                 300                

His His His His                                                  
305            


<210> 6
<211> 307
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Peptide

<400> 6
Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly  
  1               5                  10                  15    

Phe Ala Gln Ala Gln Lys Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly  
             20                  25                  30        

Arg Tyr Met Glu Asn Ser Leu Lys Glu Gln Glu Lys Leu Gly Ile Lys  
         35                  40                  45            

Leu Asp Lys Asp Gln Leu Ile Ala Gly Val Gln Asp Ala Phe Ala Asp  
     50                  55                  60                

Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr Leu Gln Ala Phe  
 65                  70                  75                  80

Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met Glu Lys Asp Ala  
                 85                  90                  95    

Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu Lys Phe Ala Lys  
            100                 105                 110        

Glu Lys Tyr Glu Asp Gly Lys Gln Tyr Thr Thr Leu Glu Lys Pro Val  
        115                 120                 125            

Ala Gly Ala Pro Gln Val Leu Glu Phe Phe Ser Phe Phe Cys Pro His  
    130                 135                 140                

Cys Tyr Gln Phe Glu Glu Val Leu His Ile Ser Asp Asn Val Lys Lys  
145                 150                 155                 160

Lys Leu Pro Glu Gly Val Lys Met Thr Lys Tyr His Val Asn Phe Met  
                165                 170                 175    

Gly Gly Asp Leu Gly Lys Asp Leu Thr Gln Ala Trp Ala Val Ala Met  
            180                 185                 190        

Ala Leu Gly Val Glu Asp Lys Val Thr Val Pro Leu Phe Glu Gly Val  
        195                 200                 205            

Gln Lys Thr Gln Thr Ile Arg Ser Ala Ser Asp Ile Arg Asp Val Phe  
    210                 215                 220                

Ile Asn Ala Gly Ile Lys Gly Glu Glu Tyr Asp Ala Ala Trp Asn Ser  
225                 230                 235                 240

Phe Val Val Lys Ser Leu Val Ala Gln Gln Glu Lys Ala Ala Ala Asp  
                245                 250                 255    

Val Gln Leu Arg Gly Val Pro Ala Met Phe Val Asn Gly Lys Tyr Gln  
            260                 265                 270        

Leu Asn Pro Gln Gly Met Asp Thr Ser Asn Met Asp Val Phe Val Gln  
        275                 280                 285            

Gln Tyr Ala Asp Thr Val Lys Tyr Leu Ser Glu Lys Lys His His His  
    290                 295                 300                

His His His                                                      
305        


<210> 7
<211> 306
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Peptide

<400> 7
Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly  
  1               5                  10                  15    

Phe Ala Gln Ala Gln Lys Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly  
             20                  25                  30        

Arg Tyr Met Glu Asn Ser Leu Lys Glu Gln Glu Lys Leu Gly Ile Lys  
         35                  40                  45            

Leu Asp Lys Asp Gln Leu Ile Ala Gly Val Gln Asp Ala Phe Ala Asp  
     50                  55                  60                

Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr Leu Gln Ala Phe  
 65                  70                  75                  80

Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met Glu Lys Asp Ala  
                 85                  90                  95    

Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu Lys Phe Ala Lys  
            100                 105                 110        

Glu Lys Glu Asp Gly Lys Gln Tyr Thr Thr Leu Glu Lys Pro Val Ala  
        115                 120                 125            

Gly Ala Pro Gln Val Leu Glu Phe Phe Ser Phe Phe Cys Pro His Cys  
    130                 135                 140                

Tyr Gln Phe Glu Glu Val Leu His Ile Ser Asp Asn Val Lys Lys Lys  
145                 150                 155                 160

Leu Pro Glu Gly Val Lys Met Thr Lys Tyr His Val Asn Phe Met Gly  
                165                 170                 175    

Gly Asp Leu Gly Lys Asp Leu Thr Gln Ala Trp Ala Val Ala Met Ala  
            180                 185                 190        

Leu Gly Val Glu Asp Lys Val Thr Val Pro Leu Phe Glu Gly Val Gln  
        195                 200                 205            

Lys Thr Gln Thr Ile Arg Ser Ala Ser Asp Ile Arg Asp Val Phe Ile  
    210                 215                 220                

Asn Ala Gly Ile Lys Gly Glu Glu Tyr Asp Ala Ala Trp Asn Ser Phe  
225                 230                 235                 240

Val Val Lys Ser Leu Val Ala Gln Gln Glu Lys Ala Ala Ala Asp Val  
                245                 250                 255    

Gln Leu Arg Gly Val Pro Ala Met Phe Val Asn Gly Lys Tyr Gln Leu  
            260                 265                 270        

Asn Pro Gln Gly Met Asp Thr Ser Asn Met Asp Val Phe Val Gln Gln  
        275                 280                 285            

Tyr Ala Asp Thr Val Lys Tyr Leu Ser Glu Lys Lys His His His His  
    290                 295                 300                

His His                                                          
305    


<210> 8
<211> 305
<212> PRT
<213> Escherichia coli

<400> 8
Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly  
  1               5                  10                  15    

Phe Ala Gln Ala Gln Lys Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly  
             20                  25                  30        

Arg Tyr Met Glu Asn Ser Leu Lys Glu Gln Glu Lys Leu Gly Ile Lys  
         35                  40                  45            

Leu Asp Lys Asp Gln Leu Ile Ala Gly Val Gln Asp Ala Phe Ala Asp  
     50                  55                  60                

Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr Leu Gln Ala Phe  
 65                  70                  75                  80

Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met Glu Lys Asp Ala  
                 85                  90                  95    

Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu Lys Phe Ala Lys  
            100                 105                 110        

Glu Lys Asp Gly Lys Gln Tyr Thr Thr Leu Glu Lys Pro Val Ala Gly  
        115                 120                 125            

Ala Pro Gln Val Leu Glu Phe Phe Ser Phe Phe Cys Pro His Cys Tyr  
    130                 135                 140                

Gln Phe Glu Glu Val Leu His Ile Ser Asp Asn Val Lys Lys Lys Leu  
145                 150                 155                 160

Pro Glu Gly Val Lys Met Thr Lys Tyr His Val Asn Phe Met Gly Gly  
                165                 170                 175    

Asp Leu Gly Lys Asp Leu Thr Gln Ala Trp Ala Val Ala Met Ala Leu  
            180                 185                 190        

Gly Val Glu Asp Lys Val Thr Val Pro Leu Phe Glu Gly Val Gln Lys  
        195                 200                 205            

Thr Gln Thr Ile Arg Ser Ala Ser Asp Ile Arg Asp Val Phe Ile Asn  
    210                 215                 220                

Ala Gly Ile Lys Gly Glu Glu Tyr Asp Ala Ala Trp Asn Ser Phe Val  
225                 230                 235                 240

Val Lys Ser Leu Val Ala Gln Gln Glu Lys Ala Ala Ala Asp Val Gln  
                245                 250                 255    

Leu Arg Gly Val Pro Ala Met Phe Val Asn Gly Lys Tyr Gln Leu Asn  
            260                 265                 270        

Pro Gln Gly Met Asp Thr Ser Asn Met Asp Val Phe Val Gln Gln Tyr  
        275                 280                 285            

Ala Asp Thr Val Lys Tyr Leu Ser Glu Lys Lys His His His His His  
    290                 295                 300                

His                                                              
305


<210> 9
<211> 342
<212> DNA
<213> Escherichia coli

<400> 9
atgaagaaag gttttatgtt gtttactttg ttagcggcgt tttcaggctt tgctcaggct 60    
cagaaatcag cttatgcact gggtgcctcg ctgggtcgtt acatggaaaa ctctctaaaa 120   
gaacaagaaa aactgggcat caaactggat aaagatcagc tgatcgctgg tgttcaggat 180   
gcatttgctg ataagagcaa actctccgac caagagatcg aacagactct acaagcattc 240   
gaagctcgcg tgaagtcttc tgctcaggcg aagatggaaa aagacgcggc tgataacgaa 300   
gcaaaaggta aagagtaccg cgagaaattt gccaaagaga aa                    342   


<210> 10
<211> 567
<212> DNA
<213> Escherichia coli

<400> 10
gcgcagtatg aagatggtaa acagtacact accctggaaa aaccggtagc tggcgcgccg 60    
caagtgctgg agtttttctc tttcttctgc ccgcactgct atcagtttga agaagttctg 120   
catatttctg ataatgtgaa gaaaaaactg ccggaaggcg tgaagatgac taaataccac 180   
gtcaacttca tgggtggtga cctgggcaaa gatctgactc aggcatgggc tgtggcgatg 240   
gcgctgggcg tggaagacaa agtgactgtt ccgctgtttg aaggcgtaca gaaaacccag 300   
accattcgtt ctgcttctga tatccgcgat gtatttatca acgcaggtat taaaggtgaa 360   
gagtacgacg cggcgtggaa cagcttcgtg gtgaaatctc tggtcgctca gcaggaaaaa 420   
gctgcagctg acgtgcaatt gcgtggcgtt ccggcgatgt ttgttaacgg taaatatcag 480   
ctgaatccgc agggtatgga taccagcaat atggatgttt ttgttcagca gtatgctgat 540   
acagtgaaat atctgtccga gaaaaaa                                     567   


<210> 11
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic

<400> 11
atgaagaaag gttttatgtt gtttactttg ttagcggcgt tttcaggctt tgctcaggct 60    
cagaaatcag cttatgcact gggtgcctcg ctgggtcgtt acatggaaaa ctctctaaaa 120   
gaacaagaaa aactgggcat caaactggat aaagatcagc tgatcgctgg tgttcaggat 180   
gcatttgctg ataagagcaa actctccgac caagagatcg aacagactct acaagcattc 240   
gaagctcgcg tgaagtcttc tgctcaggcg aagatggaaa aagacgcggc tgataacgaa 300   
gcaaaaggta aagagtaccg cgagaaattt gccaaagaga aagcgcagta tgaagatggt 360   
aaacagtaca ctaccctgga aaaaccggta gctggcgcgc cgcaagtgct ggagtttttc 420   
tctttcttct gcccgcactg ctatcagttt gaagaagttc tgcatatttc tgataatgtg 480   
aagaaaaaac tgccggaagg cgtgaagatg actaaatacc acgtcaactt catgggtggt 540   
gacctgggca aagatctgac tcaggcatgg gctgtggcga tggcgctggg cgtggaagac 600   
aaagtgactg ttccgctgtt tgaaggcgta cagaaaaccc agaccattcg ttctgcttct 660   
gatatccgcg atgtatttat caacgcaggt attaaaggtg aagagtacga cgcggcgtgg 720   
aacagcttcg tggtgaaatc tctggtcgct cagcaggaaa aagctgcagc tgacgtgcaa 780   
ttgcgtggcg ttccggcgat gtttgttaac ggtaaatatc agctgaatcc gcagggtatg 840   
gataccagca atatggatgt ttttgttcag cagtatgctg atacagtgaa atatctgtcc 900   
gagaaaaaac accaccacca ccaccactaa                                  930   


<210> 12
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic

<400> 12
atgaagaaag gttttatgtt gtttactttg ttagcggcgt tttcaggctt tgctcaggct 60    
cagaaatcag cttatgcact gggtgcctcg ctgggtcgtt acatggaaaa ctctctaaaa 120   
gaacaagaaa aactgggcat caaactggat aaagatcagc tgatcgctgg tgttcaggat 180   
gcatttgctg ataagagcaa actctccgac caagagatcg aacagactct acaagcattc 240   
gaagctcgcg tgaagtcttc tgctcaggcg aagatggaaa aagacgcggc tgataacgaa 300   
gcaaaaggta aagagtaccg cgagaaattt gccaaagaga aacagtatga agatggtaaa 360   
cagtacacta ccctggaaaa accggtagct ggcgcgccgc aagtgctgga gtttttctct 420   
ttcttctgcc cgcactgcta tcagtttgaa gaagttctgc atatttctga taatgtgaag 480   
aaaaaactgc cggaaggcgt gaagatgact aaataccacg tcaacttcat gggtggtgac 540   
ctgggcaaag atctgactca ggcatgggct gtggcgatgg cgctgggcgt ggaagacaaa 600   
gtgactgttc cgctgtttga aggcgtacag aaaacccaga ccattcgttc tgcttctgat 660   
atccgcgatg tatttatcaa cgcaggtatt aaaggtgaag agtacgacgc ggcgtggaac 720   
agcttcgtgg tgaaatctct ggtcgctcag caggaaaaag ctgcagctga cgtgcaattg 780   
cgtggcgttc cggcgatgtt tgttaacggt aaatatcagc tgaatccgca gggtatggat 840   
accagcaata tggatgtttt tgttcagcag tatgctgata cagtgaaata tctgtccgag 900   
aaaaaacacc accaccacca ccactaa                                     927   


<210> 13
<211> 924
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic

<400> 13
atgaagaaag gttttatgtt gtttactttg ttagcggcgt tttcaggctt tgctcaggct 60    
cagaaatcag cttatgcact gggtgcctcg ctgggtcgtt acatggaaaa ctctctaaaa 120   
gaacaagaaa aactgggcat caaactggat aaagatcagc tgatcgctgg tgttcaggat 180   
gcatttgctg ataagagcaa actctccgac caagagatcg aacagactct acaagcattc 240   
gaagctcgcg tgaagtcttc tgctcaggcg aagatggaaa aagacgcggc tgataacgaa 300   
gcaaaaggta aagagtaccg cgagaaattt gccaaagaga aatatgaaga tggtaaacag 360   
tacactaccc tggaaaaacc ggtagctggc gcgccgcaag tgctggagtt tttctctttc 420   
ttctgcccgc actgctatca gtttgaagaa gttctgcata tttctgataa tgtgaagaaa 480   
aaactgccgg aaggcgtgaa gatgactaaa taccacgtca acttcatggg tggtgacctg 540   
ggcaaagatc tgactcaggc atgggctgtg gcgatggcgc tgggcgtgga agacaaagtg 600   
actgttccgc tgtttgaagg cgtacagaaa acccagacca ttcgttctgc ttctgatatc 660   
cgcgatgtat ttatcaacgc aggtattaaa ggtgaagagt acgacgcggc gtggaacagc 720   
ttcgtggtga aatctctggt cgctcagcag gaaaaagctg cagctgacgt gcaattgcgt 780   
ggcgttccgg cgatgtttgt taacggtaaa tatcagctga atccgcaggg tatggatacc 840   
agcaatatgg atgtttttgt tcagcagtat gctgatacag tgaaatatct gtccgagaaa 900   
aaacaccacc accaccacca ctaa                                        924   


<210> 14
<211> 921
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic

<400> 14
atgaagaaag gttttatgtt gtttactttg ttagcggcgt tttcaggctt tgctcaggct 60    
cagaaatcag cttatgcact gggtgcctcg ctgggtcgtt acatggaaaa ctctctaaaa 120   
gaacaagaaa aactgggcat caaactggat aaagatcagc tgatcgctgg tgttcaggat 180   
gcatttgctg ataagagcaa actctccgac caagagatcg aacagactct acaagcattc 240   
gaagctcgcg tgaagtcttc tgctcaggcg aagatggaaa aagacgcggc tgataacgaa 300   
gcaaaaggta aagagtaccg cgagaaattt gccaaagaga aagaagatgg taaacagtac 360   
actaccctgg aaaaaccggt agctggcgcg ccgcaagtgc tggagttttt ctctttcttc 420   
tgcccgcact gctatcagtt tgaagaagtt ctgcatattt ctgataatgt gaagaaaaaa 480   
ctgccggaag gcgtgaagat gactaaatac cacgtcaact tcatgggtgg tgacctgggc 540   
aaagatctga ctcaggcatg ggctgtggcg atggcgctgg gcgtggaaga caaagtgact 600   
gttccgctgt ttgaaggcgt acagaaaacc cagaccattc gttctgcttc tgatatccgc 660   
gatgtattta tcaacgcagg tattaaaggt gaagagtacg acgcggcgtg gaacagcttc 720   
gtggtgaaat ctctggtcgc tcagcaggaa aaagctgcag ctgacgtgca attgcgtggc 780   
gttccggcga tgtttgttaa cggtaaatat cagctgaatc cgcagggtat ggataccagc 840   
aatatggatg tttttgttca gcagtatgct gatacagtga aatatctgtc cgagaaaaaa 900   
caccaccacc accaccacta a                                           921   


<210> 15
<211> 918
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic

<400> 15
atgaagaaag gttttatgtt gtttactttg ttagcggcgt tttcaggctt tgctcaggct 60    
cagaaatcag cttatgcact gggtgcctcg ctgggtcgtt acatggaaaa ctctctaaaa 120   
gaacaagaaa aactgggcat caaactggat aaagatcagc tgatcgctgg tgttcaggat 180   
gcatttgctg ataagagcaa actctccgac caagagatcg aacagactct acaagcattc 240   
gaagctcgcg tgaagtcttc tgctcaggcg aagatggaaa aagacgcggc tgataacgaa 300   
gcaaaaggta aagagtaccg cgagaaattt gccaaagaga aagatggtaa acagtacact 360   
accctggaaa aaccggtagc tggcgcgccg caagtgctgg agtttttctc tttcttctgc 420   
ccgcactgct atcagtttga agaagttctg catatttctg ataatgtgaa gaaaaaactg 480   
ccggaaggcg tgaagatgac taaataccac gtcaacttca tgggtggtga cctgggcaaa 540   
gatctgactc aggcatgggc tgtggcgatg gcgctgggcg tggaagacaa agtgactgtt 600   
ccgctgtttg aaggcgtaca gaaaacccag accattcgtt ctgcttctga tatccgcgat 660   
gtatttatca acgcaggtat taaaggtgaa gagtacgacg cggcgtggaa cagcttcgtg 720   
gtgaaatctc tggtcgctca gcaggaaaaa gctgcagctg acgtgcaatt gcgtggcgtt 780   
ccggcgatgt ttgttaacgg taaatatcag ctgaatccgc agggtatgga taccagcaat 840   
atggatgttt ttgttcagca gtatgctgat acagtgaaat atctgtccga gaaaaaacac 900   
caccaccacc accactaa                                               918   


<210> 16
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 16
gagctcgaat tctctagatt aaagaggaga aaggtaccca tgatgaagaa aggttttat  59    


<210> 17
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 17
atgaagaaag gttttatgtt gtttactt                                    28    


<210> 18
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 18
aagcctgaaa acgccgctaa caaagtaaac aacataaaac ctt                   43    


<210> 19
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 19
gttagcggcg ttttcaggct ttgctcaggc tgctgaagct gca                   43    


<210> 20
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 20
tgtcagcagc tgtagcaggt tttgcagctt cagcagcctg agc                   43    


<210> 21
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 21
aacctgctac agctgctgac agcaaagcag cgttcaaaaa tga                   43    


<210> 22
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 22
tgcataagct gatttctgat cgtcattttt gaacgctgct ttg                   43    


<210> 23
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 23
gatcagaaat cagcttatgc actgggtgcc tcgctgggtc gtt                   43    


<210> 24
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 24
tcttttagag agttttccat gtaacgaccc agcgaggcac cca                   43    


<210> 25
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 25
catggaaaac tctctaaaag aacaagaaaa actgggcatc aaa                   43    


<210> 26
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 26
cgatcagctg atctttatcc agtttgatgc ccagtttttc ttg                   43    


<210> 27
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 27
tggataaaga tcagctgatc gctggtgttc aggatgcatt tgc                   43    


<210> 28
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 28
gtcggagagt ttgctcttat cagcaaatgc atcctgaaca cca                   43    


<210> 29
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 29
gataagagca aactctccga ccaagagatc gaacagactc tac                   43    


<210> 30
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 30
ttcacgcgag cttcgaatgc ttgtagagtc tgttcgatct ctt                   43    


<210> 31
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 31
agcattcgaa gctcgcgtga agtcttctgc tcaggcgaag atg                   43    


<210> 32
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 32
cgttatcagc cgcgtctttt tccatcttcg cctgagcaga aga                   43    


<210> 33
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 33
aaaaagacgc ggctgataac gaagcaaaag gtaaagagta ccg                   43    


<210> 34
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 34
tttctctttg gcaaatttct cgcggtactc tttacctttt gct                   43    


<210> 35
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 35
ctgtttacca tcttcatact gcgctttctc tttggcaaat ttc                   43    


<210> 36
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 36
gtagtgtact gtttaccatc ttcatactgt ttctctttgg caaatttc              48    


<210> 37
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 37
cagggtagtg tactgtttac catcttcata tttctctttg gcaaatttc             49    


<210> 38
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 38
cagggtagtg tactgtttac catcttcttt ctctttggca aatttc                46    


<210> 39
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 39
cagggtagtg tactgtttac catctttctc tttggcaaat ttc                   43    


<210> 40
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 40
gaaatttgcc aaagagaaag cgcagtatga agatggtaaa cag                   43    


<210> 41
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 41
gaaatttgcc aaagagaaac agtatgaaga tggtaaacag tacactac              48    


<210> 42
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 42
gaaatttgcc aaagagaaat atgaagatgg taaacagtac actaccctg             49    


<210> 43
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 43
gaaatttgcc aaagagaaag aagatggtaa acagtacact accctg                46    


<210> 44
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 44
gaaatttgcc aaagagaaag atggtaaaca gtacactacc ctg                   43    


<210> 45
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 45
tttttaagct tttagtggtg gtggtggtgg tgttttttct cggacagata tttc       54    


