                         SEQUENCE LISTING

<110>  Helmholtz-Zentrum Mnchen
 
<120>  High affinity T cell receptor and use thereof

<130>  P28549

<140>
<141>

<150>  EP08020396.1
<151>  2008-11-24



<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  813
<212>  DNA
<213>  Artificial

<220>
<223>  TCR alpha chain sequence

<400>  1
atgtggggag ttttccttct ttatgtttcc atgaagatgg gaggcactac aggacaaaac     60

attgaccagc ccactgagat gacagctacg gaaggtgcca ttgtccagat caactgcacg    120

taccagacat ctgggttcaa cgggctgttc tggtaccagc aacatgctgg cgaagcaccc    180

acatttctgt cttacaatgt tctggatggt ttggaggaga aaggtcgttt ttcttcattc    240

cttagtcggt ctaaagggta cagttacctc cttttgaagg agctccagat gaaagactct    300

gcctcttacc tctgtgctgt gacatactct ggggctggga gttaccaact cactttcggg    360

aaggggacca aactctcggt cataccaaat atccagaacc ctgaccctgc cgtgtaccag    420

ctgagagact ctaaatccag tgacaagtct gtctgcctat tcaccgattt tgattctcaa    480

acaaatgtgt cacaaagtaa ggattctgat gtgtatatca cagacaaaac tgtgctagac    540

atgaggtcta tggacttcaa gagcaacagt gctgtggcct ggagcaacaa atctgacttt    600

gcatgtgcaa acgccttcaa caacagcatt attccagaag acaccttctt ccccagccca    660

gaaagttcct gtgatgtcaa gctggtcgag aaaagctttg aaacagatac gaacctaaac    720

tttcaaaacc tgtcagtgat tgggttccga atcctcctcc tgaaagtggc cgggtttaat    780

ctgctcatga cgctgcggct gtggtccagc tga                                 813


<210>  2
<211>  960
<212>  DNA
<213>  Artificial

<220>
<223>  TCR beta chain sequence

<400>  2
atgcttagtc ctgacctgcc tgactctgcc tggaacacca ggctcctctg ccatgtcatg     60

ctttgtctcc tgggagcagg ttcagtggct gctggagtca tccagtcccc aagacatctg    120

atcaaagaaa agagggaaac agccactctg aaatgctatc ctatccctag acacgacact    180

gtctactggt accagcaggg tccaggtcag gacccccagt tcctcatttc gttttatgaa    240

aagatgcaga gcgataaagg aagcatccct gatcgattct cagctcaaca gttcagtgac    300

tatcattctg aactgaacat gagctccttg gagctggggg actcagccct gtacttctgt    360

gccagcagtc agaaacaggg ctgggaaaaa ctgttttttg gcagtggaac ccagctctct    420

gtcttggagg acctgaacaa ggtgttccca cccgaggtcg ctgtgtttga gccatcagaa    480

gcagagatct cccacaccca aaaggccaca ctggtgtgcc tggccacagg cttcttccct    540

gaccacgtgg agctgagctg gtgggtgaat gggaaggagg tgcacagtgg ggtcagcacg    600

gacccgcagc ccctcaagga gcagcccgcc ctcaatgact ccagatactg cctgagcagc    660

cgcctgaggg tctcggccac cttctggcag aacccccgca accacttccg ctgtcaagtc    720

cagttctacg ggctctcgga gaatgacgag tggacccagg atagggccaa acccgtcacc    780

cagatcgtca gcgccgaggc ctggggtaga gcagactgtg gctttacctc ggtgtcctac    840

cagcaagggg tcctgtctgc caccatcctc tatgagatcc tgctagggaa ggccaccctg    900

tatgctgtgc tggtcagcgc ccttgtgttg atggccatgg tcaagagaaa ggatttctga    960


<210>  3
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence of CDR3 in TCR alpha chain

<400>  3
tgtgctgtga catactctgg ggctgggagt taccaactc                            39


<210>  4
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence of CDR3 in TCR beta chain

<400>  4
tgtgccagca gtcagaaaca gggctgggaa aaactg                               36


<210>  5
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of CDR3 in TCR alpha chain

<400>  5

Cys Ala Val Thr Tyr Ser Gly Ala Gly Ser Tyr Gln Leu 
1               5                   10              


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of CDR3 in TCR beta chain

<400>  6

Cys Ala Ser Ser Gln Lys Gln Gly Trp Glu Lys Leu 
1               5                   10          


<210>  7
<211>  381
<212>  DNA
<213>  Artificial

<220>
<223>  Codon optimized VJ region of TCR alpha chain

<400>  7
atgtggggcg tgtttctgct gtacgtgtcc atgaagatgg gcggcaccac cggccagaac     60

atcgaccagc ccaccgagat gacagccacc gagggcgcca tcgtgcagat caactgcacc    120

taccagacca gcggcttcaa cggcctgttc tggtatcagc agcacgccgg cgaggcccct    180

accttcctga gctacaacgt gctggacggc ctggaagaga agggccggtt cagcagcttc    240

ctgagccggt ccaagggcta cagctacctg ctgctgaaag aactgcagat gaaggacagc    300

gccagctacc tgtgcgccgt gacctacagc ggagccggca gctaccagct gaccttcggc    360

aagggcacca agctgtccgt g                                              381


<210>  8
<211>  426
<212>  DNA
<213>  Artificial

<220>
<223>  Codon optimized VDJ region of TCR beta chain

<400>  8
atgctgtccc ccgatctgcc cgacagcgcc tggaacacca gactgctgtg ccacgtgatg     60

ctgtgtctgc tgggagccgg atctgtggcc gctggcgtga tccagagccc cagacacctg    120

atcaaagaga agcgggagac agccaccctg aagtgctacc ccatcccccg gcacgacacc    180

gtgtactggt atcagcaggg accaggacag gacccccagt tcctgatcag cttctacgag    240

aagatgcaga gcgacaaggg cagcatcccc gacagattca gcgcccagca gttcagcgac    300

taccacagcg agctgaacat gagcagcctg gaactgggcg actctgccct gtacttctgc    360

gccagcagcc agaagcaggg ctgggagaag ctgttcttcg gcagcggcac ccagctgtcc    420

gtgctg                                                               426


