                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  c-Met Antibodies

<130>  X-18217

<150>  61/116825
<151>  2008-11-21

<150>  61/219903
<151>  2009-06-24

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Tyr Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Tyr Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  3
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Arg Leu Arg Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  4
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ile Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  5
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Val Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Arg Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Val Tyr Arg Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  7
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgtcagctc aagtataagt tccaccaact tacactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcacatcct atctggcttc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtggagta gttacccgta cagtttcggc      300

caagggacca agttggagat caaa                                             324


<210>  8
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgtcagctc aagtataagt tccaccaact tacactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcacatcct acctggcttc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtggagta gttacccgta cagtttcggc      300

caagggacca agttggagat caaa                                             324


<210>  9
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgtcagctc aagtataagt tccaccaact tacactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcacatcca gactgagatc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtggagta gttacccgta cagtttcggc      300

caagggacca agttggagat caaa                                             324


<210>  10
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgtcagctc aagtgtaagt tccatttact tgcactggta tcagcagaaa      120

ccagggaaag cccctaagct cctgatctat agcacatcca acttggcttc tggagtccca      180

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      240

cctgaagatt ttgcaactta ctactgtatt cagtacagtg gttacccgct cacgttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  11
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgtcagctc aagtgtaagt tccatttact tgcactggta tcagcagaaa      120

ccagggaaag cccctaagct cctgatctat agcacatcca acttggcttc tggagtccca      180

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      240

cctgaagatt ttgcaactta ctactgtcag gtgtacagtg gttacccgct cacgttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  12
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgtcagctc aagtgtacgt tccatttact tgcactggta tcagcagaaa      120

ccagggaaag cccctaagct cctgatctat agcacatcca acttggcttc tggagtccca      180

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      240

cctgaagatt ttgcaactta ctactgtcag gtgtacaggg gttacccgct cacgttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  13
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  14
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Phe Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  15
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Arg Glu Pro Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asn Trp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  17
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Arg Arg Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asn Trp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  18
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Tyr Arg Gly Ser Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asn Ile Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  19
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcta caccttcaca agtaggtata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atttatcctg taactggtga tacttactac      180

aacgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctac      300

ggagcttttt actactgggg ccagggcacc ctggtcaccg tctcc                      345


<210>  20
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcta caccttcaca agtaggtata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atttatcctg taactggtga tacttactac      180

atcgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat      300

ggtgcttttt tctactgggg ccagggcacc ctggtcaccg tctcc                      345


<210>  21
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcta caccttcaca agtaggtata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atttatcctg taactggtga tacttactac      180

agagagcctt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat      300

ggggcttttt actactgggg ccagggcacc ctggtcaccg tctcc                      345


<210>  22
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
caggttcagc tggtgcagtc tggtgctgag gtgaagaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactactaca tgcactgggt gcgtcaggcc      120

cctggtcaag gtcttgagtg gatgggtcgt gttaatccta accggggtgg tactacctac      180

aaccagaaat tcgagggccg tgtcaccatg accacagaca catccacgag cacagcctac      240

atggagctgc gtagcctgcg ttctgacgac acggccgtgt attactgtgc gcgtacgaac      300

tggcttgact actggggcca gggcaccacc gtcaccgtct cc                         342


<210>  23
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
caggttcagc tggtgcagtc tggtgctgag gtgaagaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactactaca tgcactgggt gcgtcaggcc      120

cctggtcaag gtcttgagtg gatgggtcgt gttaatccta accggagggg tactacctac      180

aaccagaaat tcgagggccg tgtcaccatg accacagaca catccacgag cacagcctac      240

atggagctgc gtagcctgcg ttctgacgac acggccgtgt attactgtgc gcgtgcgaac      300

tggcttgact actggggcca gggcaccacc gtcaccgtct cc                         342


<210>  24
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
caggttcagc tggtgcagtc tggtgctgag gtgaagaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacattcact gactactaca tgcactgggt gcgtcaggcc      120

cctggtcaag gtcttgagtg gatgggtcgt gttaatcctt atcggggtag tactacctac      180

aaccagaaat tcgagggccg tgtcaccatg accacagaca catccacgag cacagcctac      240

atggagctgc gtagcctgcg ttctgacgac acggccgtgt attactgtgc gcgtgcgaac      300

attcttgact actggggcca gggcaccacc gtcaccgtct cc                         342


<210>  25
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Tyr Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  26
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Tyr Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  27
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Arg Leu Arg Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  28
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ile Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  29
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Val Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  30
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Arg Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Val Tyr Arg Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  31
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgtcagctc aagtataagt tccaccaact tacactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcacatcct acctggcttc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtggagta gttacccgta cagtttcggc      300

caagggacca agttggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                      645


<210>  32
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgtcagctc aagtataagt tccaccaact tacactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcacatcct acctggcttc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtggagta gttacccgta cagtttcggc      300

caagggacca agttggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                      645


<210>  33
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgtcagctc aagtataagt tccaccaact tacactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcacatcca gactgagatc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcaa cagtggagta gttacccgta cagtttcggc      300

caagggacca agttggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                      645


<210>  34
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgtcagctc aagtgtaagt tccatttact tgcactggta tcagcagaaa      120

ccagggaaag cccctaagct cctgatctat agcacatcca acttggcttc tggagtccca      180

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      240

cctgaagatt ttgcaactta ctactgtatt cagtacagtg gttacccgct cacgttcggc      300

ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                      645


<210>  35
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgtcagctc aagtgtatcc tccatttact tgcactggta tcagcagaaa      120

ccagggaaag cccctaagct cctgatctat agcacatcca acttggcttc tggagtccca      180

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      240

cctgaagatt ttgcaactta ctactgtcaa gtctacagtg gttacccgct cacgttcggc      300

ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                      645


<210>  36
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgtcagctc aagtgtacgt tccatttact tgcactggta tcagcagaaa      120

ccagggaaag cccctaagct cctgatctat agcacatcca acttggcttc tggagtccca      180

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      240

cctgaagatt ttgcaactta ctactgtcag gtgtacaggg gttacccgct cacgttcggc      300

ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                      645


<210>  37
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440     


<210>  38
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Phe Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440     


<210>  39
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Arg Glu Pro Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Tyr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440     


<210>  40
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asn Trp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440 


<210>  41
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Arg Arg Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asn Trp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440 


<210>  42
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Tyr Arg Gly Ser Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asn Ile Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440 


<210>  43
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcta caccttcaca agtaggtata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atttatcctg taactggtga tacttactac      180

aacgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat      300

ggggcttttt actactgggg ccagggcacc ctggtcaccg tctcctccgc ctccaccaag      360

ggcccatcgg tcttcccgct agcgccctgc tccaggagca cctccgagag cacagccgcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta cacctgcaac      600

gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc      660

gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcat ggaggtgcat      840

aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc      900

ctcaccgtcg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctccg     1320

ggt                                                                   1323


<210>  44
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcta caccttcaca agtaggtata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atttatcctg taactggtga tacttactac      180

atcgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat      300

ggtgcttttt tctactgggg ccagggcacc ctggtcaccg tctcctccgc ctccaccaag      360

ggcccatcgg tcttcccgct agcgccctgc tccaggagca cctccgagag cacagccgcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta cacctgcaac      600

gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc      660

gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcat ggaggtgcat      840

aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc      900

ctcaccgtcg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctccg     1320

ggt                                                                   1323


<210>  45
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcta caccttcaca agtaggtata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atttatcctg taactggtga tacttactac      180

agagagcctt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctac      300

ggagcttttt actactgggg ccagggcacc ctggtcaccg tctcctccgc ctccaccaag      360

ggcccatcgg tcttcccgct agcgccctgc tccaggagca cctccgagag cacagccgcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta cacctgcaac      600

gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc      660

gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcat ggaggtgcat      840

aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc      900

ctcaccgtcg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctccg     1320

ggt                                                                   1323


<210>  46
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
caggttcagc tggtgcagtc tggtgctgag gtgaagaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactactaca tgcactgggt gcgtcaggcc      120

cctggtcaag gtcttgagtg gatgggtcgt gttaatccta accggggtgg tactacctac      180

aaccagaaat tcgagggccg tgtcaccatg accacagaca catccacgag cacagcctac      240

atggagctgc gtagcctgcg ttctgacgac acggccgtgt attactgtgc gcgtacgaac      300

tggcttgact actggggcca gggcaccacc gtcaccgtct cctccgcctc caccaagggc      360

ccatcggtct tcccgctagc gccctgctcc aggagcacct ccgagagcac agccgccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaacgta      600

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      660

tgcccaccct gcccagcacc tgaggccgcc gggggaccat cagtcttcct gttcccccca      720

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1020

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga aagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1320

ggt                                                                   1323


<210>  47
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
caggttcagc tggtgcagtc tggtgctgag gtgaagaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacattcact gactactaca tgcactgggt gcgtcaggcc      120

cctggtcaag gtcttgagtg gatgggtcgt gttaatccta accggagggg tactacctac      180

aaccagaaat tcgagggccg tgtcaccatg accacagaca catccacgag cacagcctac      240

atggagctgc gtagcctgcg ttctgacgac acggccgtgt attactgtgc gcgtgcgaac      300

tggcttgact actggggcca gggcaccacc gtcaccgtct cctccgcctc caccaagggc      360

ccatcggtct tcccgctagc gccctgctcc aggagcacct ccgagagcac agccgccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaacgta      600

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      660

tgcccaccct gcccagcacc tgaggccgcc gggggaccat cagtcttcct gttcccccca      720

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1020

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga aagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1320

ggt                                                                   1323


<210>  48
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
caggttcagc tggtgcagtc tggtgctgag gtgaagaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacattcact gactactaca tgcactgggt gcgtcaggcc      120

cctggtcaag gtcttgagtg gatgggtcgt gttaatcctt atcggggtag tactacctac      180

aaccagaaat tcgagggccg tgtcaccatg accacagaca catccacgag cacagcctac      240

atggagctgc gtagcctgcg ttctgacgac acggccgtgt attactgtgc gcgtgcgaac      300

attcttgact actggggcca gggcaccacc gtcaccgtct cctccgcctc caccaagggc      360

ccatcggtct tcccgctagc gccctgctcc aggagcacct ccgagagcac agccgccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaacgta      600

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      660

tgcccaccct gcccagcacc tgaggccgcc gggggaccat cagtcttcct gttcccccca      720

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1020

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga aagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1320

ggt                                                                   1323


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Ser Val Ser Ser Ser Ile Ser Ser Thr Asn Leu His 
1               5                   10          


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gly Thr Ser Tyr Leu Ala Ser 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Gln Gln Trp Ser Ser Tyr Pro Tyr Ser 
1               5                   


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gly Thr Ser Arg Leu Arg Ser 
1               5           


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Ser Val Ser Ser Ser Val Ser Ser Ile Tyr Leu His 
1               5                   10          


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Ile Gln Tyr Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Gln Val Tyr Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Ser Val Ser Ser Ser Val Arg Ser Ile Tyr Leu His 
1               5                   10          


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Gln Val Tyr Arg Gly Tyr Pro Leu Thr 
1               5                   


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Gly Tyr Thr Phe Thr Ser Arg Tyr Ile His 
1               5                   10  


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Gly Tyr Gly Ala Phe Tyr Tyr 
1               5           


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Ile Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Gly Tyr Gly Ala Phe Phe Tyr 
1               5           


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Arg Glu Pro Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   10  


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Arg Val Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Thr Asn Trp Leu Asp Tyr 
1               5       


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Arg Val Asn Pro Asn Arg Arg Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Ala Asn Trp Leu Asp Tyr 
1               5       


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Arg Val Asn Pro Tyr Arg Gly Ser Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Ala Asn Ile Leu Asp Tyr 
1               5       


<210>  72
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Leu Glu Val Leu Phe Gln Gly Pro Asp Ile Glu Pro 
    930                 935                 940                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
945                 950                 955                 960 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                965                 970                 975     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            980                 985                 990         


Val Ser His Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 
        995                 1000                 1005             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 
    1010                 1015                 1020             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1025                 1030                 1035             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1040                 1045                 1050             


Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1055                 1060                 1065             


Gln Pro  Arg Glu Pro Gln Glu  Tyr Thr Leu Pro Pro  Ser Arg Glu 
    1070                 1075                 1080             


Glu Met  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1085                 1090                 1095             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1100                 1105                 1110             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1115                 1120                 1125             


Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 
    1130                 1135                 1140             


Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1145                 1150                 1155             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 
    1160                 1165                 1170             


Lys Arg  Ile Asp Tyr Lys Asp  Asp Asp Asp Lys His  Val His His 
    1175                 1180                 1185             


His His  His His 
    1190         


<210>  73
<211>  1192
<212>  PRT
<213>  Macaca mulatta

<400>  73

Met Lys Ala Pro Ala Val Leu Val Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Ala Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Asn Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro His 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Ile His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asn Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Leu Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Ala Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Val Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Pro Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Val Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Pro Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Thr Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Ile Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu His 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Leu Glu Val Leu Phe Gln Gly Pro Asp Ile Glu Pro 
    930                 935                 940                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
945                 950                 955                 960 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                965                 970                 975     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            980                 985                 990         


Val Ser His Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 
        995                 1000                 1005             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 
    1010                 1015                 1020             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1025                 1030                 1035             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1040                 1045                 1050             


Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1055                 1060                 1065             


Gln Pro  Arg Glu Pro Gln Glu  Tyr Thr Leu Pro Pro  Ser Arg Glu 
    1070                 1075                 1080             


Glu Met  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1085                 1090                 1095             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1100                 1105                 1110             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1115                 1120                 1125             


Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 
    1130                 1135                 1140             


Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1145                 1150                 1155             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 
    1160                 1165                 1170             


Lys Arg  Ile Asp Tyr Lys Asp  Asp Asp Asp Lys His  Val His His 
    1175                 1180                 1185             


His His  His His 
    1190         


<210>  74
<211>  1194
<212>  PRT
<213>  Rattus rattus

<400>  74

Met Lys Ala Pro Thr Ala Leu Ala Pro Gly Ile Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Leu Ala Gln Arg Ser His Gly Glu Cys Lys Glu Ala Leu Val Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile His Asn Val Val Leu His Gly His His Ile Tyr Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Asp Lys Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ser Glu Phe Lys Thr Gly Pro Val Val Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Val Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Val Asn Met Ala Leu Leu Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Leu Pro Pro Asp Asn Ala Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Met Phe Ser Pro Leu Ala Glu Glu Glu Ser Gly Gln Cys Pro Asp Cys 
                165                 170                 175     


Val Val Ser Ala Leu Gly Ala Lys Val Leu Leu Ser Glu Lys Asp Arg 
            180                 185                 190         


Phe Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Pro Pro 
        195                 200                 205             


Asp Tyr Ser Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Gln 
    210                 215                 220                 


Asp Gly Phe Lys Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro 
225                 230                 235                 240 


Glu Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Ile His Ala Phe Glu Ser 
                245                 250                 255     


Asn His Phe Ile Tyr Phe Leu Thr Val Gln Lys Glu Thr Leu Asp Ala 
            260                 265                 270         


Gln Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Val Asp Ser Gly 
        275                 280                 285             


Leu His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys 
    290                 295                 300                 


Arg Arg Lys Arg Ser Thr Arg Glu Glu Val Phe Asn Ile Leu Gln Ala 
305                 310                 315                 320 


Ala Tyr Val Ser Lys Pro Gly Ala Asn Leu Ala Lys Gln Ile Gly Ala 
                325                 330                 335     


Ser Pro Tyr Asp Asp Ile Leu Tyr Gly Val Phe Ala Gln Ser Lys Pro 
            340                 345                 350         


Asp Ser Ala Glu Pro Met Asn Arg Ser Ala Val Cys Ala Phe Pro Ile 
        355                 360                 365             


Lys Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val 
    370                 375                 380                 


Arg Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn 
385                 390                 395                 400 


Arg Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Val Arg Ser Asp Glu 
                405                 410                 415     


Tyr Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met 
            420                 425                 430         


Gly Arg Leu Asn His Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys 
        435                 440                 445             


Gly Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met 
    450                 455                 460                 


Gln Val Val Leu Ser Arg Thr Ala His Phe Thr Pro His Val Asn Phe 
465                 470                 475                 480 


Leu Leu Asp Ser Tyr Pro Val Ser Pro Glu Val Ile Val Glu His Pro 
                485                 490                 495     


Ser Asn Gln Asn Gly Tyr Thr Leu Val Val Thr Gly Lys Lys Ile Thr 
            500                 505                 510         


Lys Ile Pro Leu Asn Gly Leu Gly Cys Gly His Phe Gln Ser Cys Ser 
        515                 520                 525             


Gln Cys Leu Ser Ala Pro Tyr Phe Ile Gln Cys Gly Trp Cys His Asn 
    530                 535                 540                 


Arg Cys Val His Ser Asn Glu Cys Pro Ser Gly Thr Trp Thr Gln Glu 
545                 550                 555                 560 


Ile Cys Leu Pro Ala Val Tyr Lys Val Phe Pro Thr Ser Ala Pro Leu 
                565                 570                 575     


Glu Gly Gly Thr Met Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Lys 
            580                 585                 590         


Lys Asn Asn Lys Phe Asp Leu Arg Lys Thr Lys Val Leu Leu Gly Asn 
        595                 600                 605             


Glu Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Thr Asn Thr Leu Lys 
    610                 615                 620                 


Cys Thr Val Gly Pro Ala Met Ser Glu His Phe Asn Val Ser Val Ile 
625                 630                 635                 640 


Val Ser Asn Ser Arg Glu Thr Thr Gln Tyr Ser Ala Phe Ser Tyr Val 
                645                 650                 655     


Asp Pro Val Ile Thr Ser Ile Ser Pro Arg Tyr Gly Pro His Ala Gly 
            660                 665                 670         


Gly Thr Leu Leu Thr Leu Thr Gly Lys Tyr Leu Asn Ser Gly Asn Ser 
        675                 680                 685             


Arg His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser 
    690                 695                 700                 


Asp Ser Ile Leu Glu Cys Tyr Thr Pro Gly His Thr Val Ser Ala Glu 
705                 710                 715                 720 


Phe Pro Val Lys Leu Lys Ile Asp Leu Ala Asp Arg Val Thr Ser Ser 
                725                 730                 735     


Phe Ser Tyr Arg Glu Asp Pro Val Val Ser Glu Ile His Pro Thr Lys 
            740                 745                 750         


Ser Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Ile Gly Lys Asn Leu 
        755                 760                 765             


Asn Ser Val Ser Thr Pro Lys Leu Val Ile Glu Val His Asp Val Gly 
    770                 775                 780                 


Val Asn Tyr Thr Val Ala Cys Gln His Arg Ser Ser Ser Glu Ile Ile 
785                 790                 795                 800 


Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asp Leu Gln Leu Pro Leu 
                805                 810                 815     


Lys Thr Lys Ala Phe Phe Leu Leu Asp Gly Ile Leu Ser Lys His Phe 
            820                 825                 830         


Asp Leu Thr Tyr Val His Asp Pro Met Phe Lys Pro Phe Glu Lys Pro 
        835                 840                 845             


Val Met Ile Ser Met Gly Asn Glu Asn Val Val Glu Ile Lys Gly Asp 
    850                 855                 860                 


Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn 
865                 870                 875                 880 


Lys Ser Cys Glu Asn Leu His Trp His Ser Glu Ala Leu Leu Cys Thr 
                885                 890                 895     


Val Pro Ser Asp Leu Leu Lys Leu Asn Gly Gly Glu Leu Asn Ile Glu 
            900                 905                 910         


Trp Lys Gln Ala Val Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
        915                 920                 925             


Pro Asp Gln Asn Phe Ala Leu Glu Val Leu Phe Gln Gly Pro Asp Ile 
    930                 935                 940                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
945                 950                 955                 960 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                965                 970                 975     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            980                 985                 990         


Val Asp Val Ser His Glu Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val 
        995                 1000                 1005             


Asp Gly  Val Glu Val His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu 
    1010                 1015                 1020             


Gln Tyr  Asn Ser Thr Tyr Arg  Val Val Ser Val Leu  Thr Val Leu 
    1025                 1030                 1035             


His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser 
    1040                 1045                 1050             


Asn Lys  Ala Leu Pro Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala 
    1055                 1060                 1065             


Lys Gly  Gln Pro Arg Glu Pro  Gln Glu Tyr Thr Leu  Pro Pro Ser 
    1070                 1075                 1080             


Arg Glu  Glu Met Thr Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val 
    1085                 1090                 1095             


Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn 
    1100                 1105                 1110             


Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp 
    1115                 1120                 1125             


Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys 
    1130                 1135                 1140             


Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser Cys Ser  Val Met His 
    1145                 1150                 1155             


Glu Ala  Leu His Asn His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser 
    1160                 1165                 1170             


Pro Gly  Lys Arg Ile Asp Tyr  Lys Asp Asp Asp Asp  Lys His Val 
    1175                 1180                 1185             


His His  His His His His 
    1190                 


<210>  75
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr 
    930         


<210>  76
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Asp Tyr Lys Asp Asp Asp Asp Lys His Val His His His His 
                565                 570                 575     


His His 
        


<210>  77
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  77

Val Val Asp Thr Tyr Tyr Asp Asp Gln Leu 
1               5                   10  


<210>  78
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  78

Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His Val Phe 
1               5                   10                  15      


Pro His Asn His Thr Ala Asp Ile Gln 
            20                  25  


<210>  79
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe Ile Asn 
1               5                   10                  15      


Phe Phe 
        


<210>  80
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  80

Val Arg Arg Leu Lys Glu Thr Lys Asp Gly Phe Met 
1               5                   10          


<210>  81
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  81

Asp Thr Tyr Tyr Asp Asp 
1               5       


<210>  82
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  82

His Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser 
1               5                   10              


<210>  83
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  83

Phe Ile Asn Phe 
1               


<210>  84
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  84

Lys Glu Thr Lys Asp Gly Phe Met 
1               5               


<210>  85
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  85

Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe Pro Cys Gln 
1               5                   10                  15      


Asp Cys Ser Ser Lys Ala Asn Leu 
            20                  


<210>  86
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  86

Cys Phe Pro Cys Gln Asp Cys Ser Ser Lys Ala 
1               5                   10      


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  87

Gly Thr Ser Xaa Leu Xaa Ser 
1               5           


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  88

Ser Val Ser Ser Ser Val Xaa Ser Ile Tyr Leu His 
1               5                   10          


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  89

Xaa Xaa Tyr Xaa Gly Tyr Pro Leu Thr 
1               5                   


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  90

Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Xaa Glu Xaa Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Gly Tyr Gly Ala Phe Xaa Tyr 
1               5           


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  92

Arg Val Asn Pro Xaa Arg Xaa Xaa Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  93

Xaa Asn Xaa Leu Asp Tyr 
1               5       


<210>  94
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Val Ser Ser Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Xaa Leu Xaa Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  95
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Xaa Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Tyr Xaa Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  96
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Arg 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Thr Gly Asp Thr Tyr Tyr Xaa Glu Xaa Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ala Phe Xaa Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  97
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Asn Pro Xaa Arg Xaa Xaa Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Asn Xaa Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser 
        


