                         SEQUENCE LISTING

<110>  SANOFI-AVENTIS
 
<120>  ANTITUMOR COMBINATIONS CONTAINING ANTIBODIES RECOGNIZING 
       SPECIFICALLY CD38 AND VINCRISTINE

<130>  FR2008-112

<160>  80    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  1

Ser Tyr Gly Met Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  2

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  3

Arg Gly Phe Ala Tyr 
1               5   


<210>  4
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  4

Arg Ala Ser Glu Ser Val Glu Ile Tyr Gly Asn Gly Phe Met Asn 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  5

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  6

Gln Gln Ile Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  7

Asn Ser Gly Met Asn 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  8

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  9

Arg Gly Phe Val Tyr 
1               5   


<210>  10
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  10

Arg Ala Ser Glu Ser Val Ala Ile Tyr Gly Asn Ser Phe Leu Lys 
1               5                   10                  15  


<210>  11
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  11

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  12

Gln Gln Ile Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  13

Asp Tyr Trp Met Gln 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  14

Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  15

Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  16

Lys Ala Ser Gln Asp Val Ser Thr Val Val Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  17

Ser Ala Ser Tyr Arg Tyr Ile 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  18

Gln Gln His Tyr Ser Pro Pro Tyr Thr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  19

Gly Ser Trp Met Asn 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  20

Arg Ile Tyr Pro Gly Asp Gly Asp Ile Ile Tyr Asn Gly Asn Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  21

Trp Gly Thr Phe Thr Pro Ser Phe Asp Tyr 
1               5                   10  


<210>  22
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  22

Lys Ala Ser Gln Asp Val Val Thr Ala Val Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  23

Ser Ala Ser His Arg Tyr Thr 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  24

Gln Gln His Tyr Thr Thr Pro Thr Thr 
1               5                   


<210>  25
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  25

Ser Tyr Thr Leu Ser 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  26

Thr Ile Ser Ile Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  27

Asp Phe Asn Gly Tyr Ser Asp Phe 
1               5               


<210>  28
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  28

Lys Ala Ser Gln Val Val Gly Ser Ala Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  29

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  30

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  31
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  31

Asn Phe Gly Met His 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  32

Tyr Ile Arg Ser Gly Ser Gly Thr Ile Tyr Tyr Ser Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  33

Ser Tyr Tyr Asp Phe Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  34

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  35

Ser Ala Ser Ser Arg Tyr Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  36

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  37
<211>  336
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(336)

<400>  37
aac att gtg ctg acc caa tct cca gct tct ttg gct gtg tct ctt ggg       48
Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly         
1               5                   10                  15              

cag agg gcc acc ata tcc tgc aga gcc agt gaa agt gtt gag att tat       96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Ile Tyr         
            20                  25                  30                  

ggc aat ggt ttt atg aac tgg ttc cag cag aaa cca gga cag cca ccc      144
Gly Asn Gly Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro         
        35                  40                  45                      

aaa ctc ctc atc tat cgt gca tcc aac cta gaa tct ggg atc cct gcc      192
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala         
    50                  55                  60                          

agg ttc agt ggc agt ggg tct agg aca gag ttc acc ctc acc att gat      240
Arg Phe Ser Gly Ser Gly Ser Arg Thr Glu Phe Thr Leu Thr Ile Asp         
65                  70                  75                  80          

cct gtg gag gct gat gat gtt gca acc tat tac tgt caa caa att aat      288
Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ile Asn         
                85                  90                  95              

gag gat cca ttc acg ttc ggc tcg ggg aca aag ttg gaa ata aaa cgg      336
Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg         
            100                 105                 110                 


<210>  38
<211>  112
<212>  PRT
<213>  Mus sp.

<400>  38

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Ile Tyr 
            20                  25                  30          


Gly Asn Gly Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Glu Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ile Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  39
<211>  336
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(336)

<400>  39
gac att gta ctg acc caa tct cca gct tct ttg gct gtg tct cta ggg       48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly         
1               5                   10                  15              

cag agg gcc acc ata tcc tgc aga gcc agt gag agt gtt gct att tat       96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ala Ile Tyr         
            20                  25                  30                  

ggc aat agt ttt ctg aaa tgg ttc cag cag aaa ccg gga cag cca ccc      144
Gly Asn Ser Phe Leu Lys Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro         
        35                  40                  45                      

aaa ctc ctc atc tat cgt gca tcc aac cta gaa tct ggg atc cct gcc      192
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala         
    50                  55                  60                          

agg ttc agt ggc agt ggg tct ggg aca gac ttc acc ctc acc att aat      240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn         
65                  70                  75                  80          

cct gtg gag gct gat gat gtt gca acc tat tac tgt cag caa att aat      288
Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ile Asn         
                85                  90                  95              

gag gat ccg tac acg ttc gga ggg ggg acc aag ctg gaa ata aaa cgg      336
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg         
            100                 105                 110                 


<210>  40
<211>  112
<212>  PRT
<213>  Mus sp.

<400>  40

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ala Ile Tyr 
            20                  25                  30          


Gly Asn Ser Phe Leu Lys Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ile Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  41
<211>  324
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(324)

<400>  41
gac att gtg atg gcc cag tct cac aaa ttc atg tcc aca tca gtt gga       48
Asp Ile Val Met Ala Gln Ser His Lys Phe Met Ser Thr Ser Val Gly         
1               5                   10                  15              

gac agg gtc agc atc acc tgc aag gcc agt cag gat gtg agt act gtt       96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val         
            20                  25                  30                  

gtg gcc tgg tat caa cag aaa cca gga caa tct cct aaa cga ctg att      144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile         
        35                  40                  45                      

tac tcg gca tcc tat cgg tat att gga gtc cct gat cgc ttc act ggc      192
Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

agt gga tct ggg acg gat ttc act ttc acc atc agc agt gtg cag gct      240
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala         
65                  70                  75                  80          

gaa gac ctg gca gtt tat tac tgt cag caa cat tat agt cct ccg tac      288
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr         
                85                  90                  95              

acg ttc gga ggg ggg acc aag ctg gaa ata aaa cgg                      324
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  42
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  42

Asp Ile Val Met Ala Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  43
<211>  324
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(324)

<400>  43
gac att gtg atg acc cag tct cac aaa ttc ttg tcc aca tca gtt gga       48
Asp Ile Val Met Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly         
1               5                   10                  15              

gac agg gtc agt atc acc tgc aag gcc agt cag gat gtg gtt act gct       96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Val Thr Ala         
            20                  25                  30                  

gtt gcc tgg ttt caa cag aaa cca gga caa tct cca aaa cta ctg att      144
Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile         
        35                  40                  45                      

tat tcg gca tcc cac cgg tac act gga gtc cct gat cgc ttc act ggc      192
Tyr Ser Ala Ser His Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc act ttc acc atc atc agt gtg cag gct      240
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ile Ser Val Gln Ala         
65                  70                  75                  80          

gaa gac ctg gca gtt tat tac tgt caa caa cat tat act act ccc acg      288
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Thr         
                85                  90                  95              

acg ttc ggt gga ggc acc aag ctg gac ttc aga cgg                      324
Thr Phe Gly Gly Gly Thr Lys Leu Asp Phe Arg Arg                         
            100                 105                                     


<210>  44
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  44

Asp Ile Val Met Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Val Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser His Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ile Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Thr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Asp Phe Arg Arg 
            100                 105             


<210>  45
<211>  324
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(324)

<400>  45
gac act gtg atg acc cag tct cac aaa ttc ata tcc aca tca gtt gga       48
Asp Thr Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly         
1               5                   10                  15              

gac agg gtc agc atc acc tgc aag gcc agt cag gtt gtg ggt agt gct       96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Val Val Gly Ser Ala         
            20                  25                  30                  

gta gcc tgg tat caa cag aaa cca ggg caa tct cct aaa cta ctg att      144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile         
        35                  40                  45                      

tac tgg gca tcc acc cgg cac act gga gtc cct gat cgc ttc aca ggc      192
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc act ctc acc att agc aat gtg cag tct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser         
65                  70                  75                  80          

gaa gac ttg gca gat tat ttc tgt cag caa tat aac agc tat ccg tac      288
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr         
                85                  90                  95              

acg ttc gga ggg ggg acc aag ctg gaa ata aaa cgg                      324
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  46
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  46

Asp Thr Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Val Val Gly Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  47
<211>  324
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(324)

<400>  47
gac att gtg atg acc cag tct caa aaa ttc atg tcc aca tca gta gga       48
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly         
1               5                   10                  15              

gac agg gtc agc gtc acc tgc aag gcc agt cag aat gtg ggt act aat       96
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn         
            20                  25                  30                  

gtt gcc tgg tat caa cac aaa cca gga caa tcc cct aaa ata atg att      144
Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ser Pro Lys Ile Met Ile         
        35                  40                  45                      

tat tcg gcg tcc tcc cgg tac agt gga gtc cct gat cgc ttc aca ggc      192
Tyr Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

agt gga tct ggg aca ctt ttc act ctc acc atc aac aat gtg cag tct      240
Ser Gly Ser Gly Thr Leu Phe Thr Leu Thr Ile Asn Asn Val Gln Ser         
65                  70                  75                  80          

gaa gac ttg gca gag tat ttc tgt cag caa tat aac agc tat cct ctc      288
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu         
                85                  90                  95              

acg ttc ggc tcg ggg aca aag ttg gaa ata aaa cgg                      324
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  48
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  48

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ser Pro Lys Ile Met Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Leu Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  49
<211>  342
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(342)

<400>  49
cag atc cag ttg gtg cag tct gga cct gag ctg aag aag cct gga gag       48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu         
1               5                   10                  15              

aca gtc aag atc tcc tgc aag gct tct ggg tat acc ctc aca agc tac       96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ser Tyr         
            20                  25                  30                  

gga atg aac tgg gtg aag cag gct cca gga aag ggt tta aag tgg atg      144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met         
        35                  40                  45                      

ggc tgg ata aac acc tac act gga gaa cca aca tat gct gat gac ttt      192
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe         
    50                  55                  60                          

aag gga cgt ttt gcc ttc tct ttg gaa acc tct gcc agc act gcc ttt      240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe         
65                  70                  75                  80          

ttg cag atc aac aac ctc aaa aat gag gac acg gct aca tat ttc tgt      288
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys         
                85                  90                  95              

gta aga cgc ggg ttt gct tac tgg ggc caa ggg act ctg gtc act gtc      336
Val Arg Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val         
            100                 105                 110                 

tct gca                                                              342
Ser Ala                                                                 
                                                                        


<210>  50
<211>  114
<212>  PRT
<213>  Mus sp.

<400>  50

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  51
<211>  342
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(342)

<400>  51
cag atc cag ttg gtg cag tct gga cct gag ctg aag aag cct gga gag       48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu         
1               5                   10                  15              

aca gtc aag atc tcc tgc aag gct tct ggg tat acc ttc aca aac tct       96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser         
            20                  25                  30                  

gga atg aac tgg gtg aag cag gct cca gga aag ggt tta aag tgg atg      144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met         
        35                  40                  45                      

ggc tgg ata aac acc tac act gga gag ccg aca tat gct gat gac ttc      192
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe         
    50                  55                  60                          

aag gga cgg ttt gcc ttc tct ttg gaa acc tct gcc agc tct gcc tat      240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr         
65                  70                  75                  80          

ttg cag atc agt aac ctc aaa aat gag gac acg gct aca tat ttc tgt      288
Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys         
                85                  90                  95              

gca aga agg ggt ttt gtt tac tgg ggc caa ggg act ctg gta act gtc      336
Ala Arg Arg Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val         
            100                 105                 110                 

tct gca                                                              342
Ser Ala                                                                 
                                                                        


<210>  52
<211>  114
<212>  PRT
<213>  Mus sp.

<400>  52

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  53
<211>  360
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(360)

<400>  53
cag gtt cag ctc cag cag tct ggg gct gag ctg gca aga cct ggg act       48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Thr         
1               5                   10                  15              

tca gtg aag ttg tcc tgt aag gct tct ggc tac acc ttt act gac tac       96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

tgg atg cag tgg gta aaa cag agg cct gga cag ggt ctg gag tgg att      144
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg act att tat cct gga gat ggt gat act ggg tac gct cag aag ttc      192
Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe         
    50                  55                  60                          

aag ggc aag gcc aca ttg act gcg gat aaa tcc tcc aaa aca gtc tac      240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Lys Thr Val Tyr         
65                  70                  75                  80          

atg cac ctc agc agt ttg gct tct gag gac tct gcg gtc tat tac tgt      288
Met His Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gat tac tac ggt agt aat tct ttg gac tat tgg ggt caa      336
Ala Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr Trp Gly Gln         
            100                 105                 110                 

gga acc tca gtc acc gtc tcc tca                                      360
Gly Thr Ser Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  54
<211>  120
<212>  PRT
<213>  Mus sp.

<400>  54

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Lys Thr Val Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  357
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(357)

<400>  55
cag gtc cag tta cag caa tct gga cct gaa ctg gtg agg cct ggg gcc       48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala         
1               5                   10                  15              

tca gtg aag att tcc tgc aaa act tct ggc tac gca ttc agt ggc tcc       96
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ala Phe Ser Gly Ser         
            20                  25                  30                  

tgg atg aac tgg gtg aag cag agg cct gga cag ggt cta gag tgg att      144
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile         
        35                  40                  45                      

gga cgg att tat ccg gga gat gga gat atc att tac aat ggg aat ttc      192
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Ile Ile Tyr Asn Gly Asn Phe         
    50                  55                  60                          

agg gac aag gtc aca ctg tct gca gac aaa tcc tcc aac aca gcc tac      240
Arg Asp Lys Val Thr Leu Ser Ala Asp Lys Ser Ser Asn Thr Ala Tyr         
65                  70                  75                  80          

atg cag ctc agc agc ctg acc tct gtg gac tct gcg gtc tat ttt tgt      288
Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys         
                85                  90                  95              

tcg aga tgg ggg aca ttt acg ccg agt ttt gac tat tgg ggc caa ggc      336
Ser Arg Trp Gly Thr Phe Thr Pro Ser Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc act ctc aca gtc tcc tca                                          357
Thr Thr Leu Thr Val Ser Ser                                             
        115                                                             


<210>  56
<211>  119
<212>  PRT
<213>  Mus sp.

<400>  56

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ala Phe Ser Gly Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Ile Ile Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Arg Asp Lys Val Thr Leu Ser Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Trp Gly Thr Phe Thr Pro Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  57
<211>  351
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(351)

<400>  57
gac gtg aag ctg gtg gag tct ggg gga ggc tta gtg aag cct gga ggg       48
Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly         
1               5                   10                  15              

tcc ctg aaa ctc tcc tgt gaa gcc tct gga ttc act ttc agt agc tat       96
Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

acc ctg tct tgg gtt cgc cag act ccg gag acg agg ctg gag tgg gtc      144
Thr Leu Ser Trp Val Arg Gln Thr Pro Glu Thr Arg Leu Glu Trp Val         
        35                  40                  45                      

gca acc att agt att ggt ggt cgc tac acc tat tat cca gac agt gtg      192
Ala Thr Ile Ser Ile Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val         
    50                  55                  60                          

gag ggc cga ttc acc atc tcc aga gac aat gcc aag aac acc ctg tac      240
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agt ctg aag tct gag gac aca gcc atg tat tac tgt      288
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys         
                85                  90                  95              

aca aga gat ttt aat ggt tac tct gac ttc tgg ggc caa ggc acc act      336
Thr Arg Asp Phe Asn Gly Tyr Ser Asp Phe Trp Gly Gln Gly Thr Thr         
            100                 105                 110                 

ctc aca gtc tcc tca                                                  351
Leu Thr Val Ser Ser                                                     
        115                                                             


<210>  58
<211>  117
<212>  PRT
<213>  Mus sp.

<400>  58

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Leu Ser Trp Val Arg Gln Thr Pro Glu Thr Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ile Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Phe Asn Gly Tyr Ser Asp Phe Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  59
<211>  360
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(360)

<400>  59
aat gta cag ctg gta gag tct ggg gga ggc tta gtg cag cct gga ggg       48
Asn Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tcc cgg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt aac ttt       96
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe         
            20                  25                  30                  

gga atg cac tgg gtt cgt cag gct cca gag aag ggt ctg gag tgg gtc      144
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca tac att cgt agt ggc agt ggt acc atc tac tat tca gac aca gtg      192
Ala Tyr Ile Arg Ser Gly Ser Gly Thr Ile Tyr Tyr Ser Asp Thr Val         
    50                  55                  60                          

aag ggc cga ttc acc atc tcc aga gac aat ccc aag aac acc ctg ttc      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe         
65                  70                  75                  80          

ctg caa atg acc agt cta agg tct gag gac acg gcc atg tat tac tgt      288
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys         
                85                  90                  95              

gca aga tcc tac tat gat ttc ggg gcc tgg ttt gct tac tgg ggc caa      336
Ala Arg Ser Tyr Tyr Asp Phe Gly Ala Trp Phe Ala Tyr Trp Gly Gln         
            100                 105                 110                 

ggg act ctg gtc act gtc tct gca                                      360
Gly Thr Leu Val Thr Val Ser Ala                                         
        115                 120                                         


<210>  60
<211>  120
<212>  PRT
<213>  Mus sp.

<400>  60

Asn Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Gly Ser Gly Thr Ile Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Asp Phe Gly Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  61
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)

<400>  61
gat atc gta atg acc cag tcc cac ctg agt atg agt acc tcc ctg gga       48
Asp Ile Val Met Thr Gln Ser His Leu Ser Met Ser Thr Ser Leu Gly         
1               5                   10                  15              

gat cct gtg tca atc act tgc aag gcc tca cag gat gtg agc acc gtc       96
Asp Pro Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val         
            20                  25                  30                  

gtt gct tgg tat cag cag aag ccc ggg caa tca ccc aga cgt ctc atc      144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile         
        35                  40                  45                      

tac tca gca tca tac cgt tac atc ggg gtg cct gac cga ttt act ggc      192
Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

tct ggc gct ggc aca gat ttc acc ttt aca att agt tcc gtc cag gcc      240
Ser Gly Ala Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala         
65                  70                  75                  80          

gaa gac ctg gcc gtg tac tac tgc cag cag cac tac agt ccc cca tac      288
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr         
                85                  90                  95              

act ttc ggg gga ggg act aag ctc gaa atc aaa cgt                      324
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  62
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  62

Asp Ile Val Met Thr Gln Ser His Leu Ser Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Pro Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ala Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  63
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)

<400>  63
gac att gtt atg gct caa agc cat ctg tct atg agc aca tct ctg gga       48
Asp Ile Val Met Ala Gln Ser His Leu Ser Met Ser Thr Ser Leu Gly         
1               5                   10                  15              

gat cct gtg tcc atc act tgc aaa gcc agt caa gac gtg tct aca gtt       96
Asp Pro Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val         
            20                  25                  30                  

gtt gca tgg tat caa cag aag cca ggc cag tca ccc aga cgg ctc att      144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile         
        35                  40                  45                      

tac tca gct tct tac cga tac atc ggg gtc cct gac aga ttt aca ggt      192
Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

agt ggg gcc ggt act gac ttc act ttt act atc tca tcc gta caa gcc      240
Ser Gly Ala Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala         
65                  70                  75                  80          

gaa gac ctg gca gta tat tac tgc cag caa cat tat tcc cca ccc tac      288
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr         
                85                  90                  95              

aca ttc ggc ggg ggt act aag ctg gaa att aaa cgt                      324
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  64
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  64

Asp Ile Val Met Ala Gln Ser His Leu Ser Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Pro Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ala Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  65
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)

<400>  65
cag gta cag ctc gtt cag tcc ggc gcc gag gta gct aag cct ggt act       48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Thr         
1               5                   10                  15              

tcc gta aaa ttg tcc tgt aag gct tcc ggg tac aca ttt aca gac tac       96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

tgg atg cag tgg gta aaa cag cgg cca ggt cag ggc ctg gag tgg att      144
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile         
        35                  40                  45                      

gga aca ata tat ccc ggc gac ggc gac aca ggc tat gcc cag aag ttt      192
Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe         
    50                  55                  60                          

caa ggc aag gca acc ctt act gct gat aaa tct tcc aag act gtc tac      240
Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Lys Thr Val Tyr         
65                  70                  75                  80          

atg cat ctg tct tcc ttg gca tct gag gat agc gct gtc tat tac tgt      288
Met His Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys         
                85                  90                  95              

gct agg ggg gac tac tat ggg tca aat tcc ctg gat tac tgg ggc cag      336
Ala Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr Trp Gly Gln         
            100                 105                 110                 

ggc acc agt gtc acc gtg agc agc                                      360
Gly Thr Ser Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  66
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Lys Thr Val Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)

<400>  67
gac acc gtg atg acc cag tcc ccc tcc acc atc tcc acc tct gtg ggc       48
Asp Thr Val Met Thr Gln Ser Pro Ser Thr Ile Ser Thr Ser Val Gly         
1               5                   10                  15              

gac cgg gtg tcc atc acc tgt aag gcc tcc cag gtg gtg ggc tcc gcc       96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Val Val Gly Ser Ala         
            20                  25                  30                  

gtg gcc tgg tat cag cag aag cct ggc cag tcc cct aag ctg ctg atc      144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile         
        35                  40                  45                      

tac tgg gcc tcc acc cgg cat acc ggc gtg cct gac cgg ttc acc ggc      192
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly         
    50                  55                  60                          

tcc ggc agc ggc acc gac ttc acc ctg acc atc tcc aac gtg cag tcc      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser         
65                  70                  75                  80          

gac gac ctg gcc gac tac ttc tgc cag cag tac aac tcc tac cct tac      288
Asp Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr         
                85                  90                  95              

acc ttt ggc ggc gga aca aag ctg gag atc aag cgt                      324
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  68
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  68

Asp Thr Val Met Thr Gln Ser Pro Ser Thr Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Val Val Gly Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Asp Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  69
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)

<400>  69
gac acc gtg atg acc cag tcc ccc tcc tcc atc tcc acc tcc atc ggc       48
Asp Thr Val Met Thr Gln Ser Pro Ser Ser Ile Ser Thr Ser Ile Gly         
1               5                   10                  15              

gac cgg gtg tcc atc acc tgt aag gcc tcc cag gtg gtg ggc tcc gcc       96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Val Val Gly Ser Ala         
            20                  25                  30                  

gtg gcc tgg tat cag cag aag cct ggc cag tcc cct aag ctg ctg atc      144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile         
        35                  40                  45                      

tac tgg gcc tcc acc cgg cat acc ggc gtg cct gcc cgg ttc acc ggc      192
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ala Arg Phe Thr Gly         
    50                  55                  60                          

tcc ggc agc ggc acc gac ttc acc ctg acc atc tcc aac gtg cag tcc      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser         
65                  70                  75                  80          

gag gac ctg gcc gac tac ttc tgc cag cag tac aac tcc tac cct tac      288
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr         
                85                  90                  95              

acc ttt ggc ggc gga aca aag ctg gag atc aag cgt                      324
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg                         
            100                 105                                     


<210>  70
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  70

Asp Thr Val Met Thr Gln Ser Pro Ser Ser Ile Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Val Val Gly Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  71
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(351)

<400>  71
gag gtg cag ctg gtg gag tct ggc ggc gga ctg gtg aag cct ggc ggc       48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly         
1               5                   10                  15              

tcc ctg agg ctg tcc tgt gag gcc tcc ggc ttc acc ttc tcc tcc tac       96
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

acc ctg tcc tgg gtg agg cag acc cct ggc aag ggc ctg gag tgg gtg      144
Thr Leu Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gcc acc atc tcc atc ggc ggc agg tac acc tac tac cct gac tcc gtg      192
Ala Thr Ile Ser Ile Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val         
    50                  55                  60                          

aag ggc cgg ttc acc atc tcc cgg gac aac gcc aag aac acc ctg tac      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg cag atg aac tcc ctg aag tcc gag gac acc gcc atg tac tac tgt      288
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys         
                85                  90                  95              

acc cgg gac ttc aac ggc tac tcc gac ttc tgg ggc cag ggc acc aca      336
Thr Arg Asp Phe Asn Gly Tyr Ser Asp Phe Trp Gly Gln Gly Thr Thr         
            100                 105                 110                 

ctg acc gtg tcc tcc                                                  351
Leu Thr Val Ser Ser                                                     
        115                                                             


<210>  72
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Leu Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ile Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Phe Asn Gly Tyr Ser Asp Phe Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  73
<211>  36
<212>  DNA
<213>  Mus sp.

<400>  73
ggaggatcca tagacagatg ggggtgtcgt tttggc                               36


<210>  74
<211>  32
<212>  DNA
<213>  Mus sp.

<400>  74
ggaggatccc ttgaccaggc atcctagagt ca                                   32


<210>  75
<211>  32
<212>  DNA
<213>  Mus sp.


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  mixed bases are defined as follows: H=A+T+C, S=G+C, Y=C+T,  K= 
       G+T,  M=A+C,  R=A+G,  W=A+T,  V = A+C+G, N = A+C+G+T

<400>  75
cttccggaat tcsargtnma gctgsagsag tc                                   32


<210>  76
<211>  35
<212>  DNA
<213>  Mus sp.


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  mixed bases are defined as follows: H=A+T+C, S=G+C, Y=C+T,  K= 
       G+T,  M=A+C,  R=A+G,  W=A+T,  V = A+C+G, N = A+C+G+T

<400>  76
cttccggaat tcsargtnma gctgsagsag tcwgg                                35


<210>  77
<211>  31
<212>  DNA
<213>  Mus sp.


<220>
<221>  misc_feature
<222>  (1)..(31)
<223>  mixed bases are defined as follows: H=A+T+C, S=G+C, Y=C+T,  K= 
       G+T,  M=A+C,  R=A+G,  W=A+T,  V = A+C+G, N = A+C+G+T

<400>  77
ggagctcgay attgtgmtsa cmcarwctmc a                                    31


<210>  78
<211>  46
<212>  DNA
<213>  Mus sp.

<400>  78
tatagagctc aagcttggat ggtgggaaga tggatacagt tggtgc                    46


<210>  79
<211>  21
<212>  DNA
<213>  Mus sp.

<400>  79
atggagtcac agattcaggt c                                               21


<210>  80
<211>  32
<212>  DNA
<213>  Mus sp.

<400>  80
ttttgaattc cagtaacttc aggtgtccac tc                                   32


