                         SEQUENCE LISTING

<110>  GE Healthcare UK Limited
 
<120>  Methods for Testing Binding of a Ligand to a G Protein-Coupled 
       Receptor

<130>  PA0898

<150>  GB0822259.8
<151>  2008-12-05

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Glu Leu Asp Gln Leu Arg Gln Glu Ala Glu Gln Leu Lys 
            100                 105                 110         


Asn Gln Ile Arg Asp Ala Arg Lys Ala Cys Ala Asp Ala Thr Leu Ser 
        115                 120                 125             


Gln Ile Thr Asn Asn Ile Asp Pro Val Gly Arg Ile Gln Met Arg Thr 
    130                 135                 140                 


Arg Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp 
145                 150                 155                 160 


Gly Thr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu 
                165                 170                 175     


Ile Ile Trp Asp Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu 
            180                 185                 190         


Arg Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Tyr 
        195                 200                 205             


Val Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Asn Leu Lys 
    210                 215                 220                 


Thr Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Ala Gly His Thr 
225                 230                 235                 240 


Gly Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Asn Gln Ile Val Thr 
                245                 250                 255     


Ser Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln 
            260                 265                 270         


Gln Thr Thr Thr Phe Thr Gly His Thr Gly Asp Val Met Ser Leu Ser 
        275                 280                 285             


Leu Ala Pro Asp Thr Arg Leu Phe Val Ser Gly Ala Cys Asp Ala Ser 
    290                 295                 300                 


Ala Lys Leu Trp Asp Val Arg Glu Gly Met Cys Arg Gln Thr Phe Thr 
305                 310                 315                 320 


Gly His Glu Ser Asp Ile Asn Ala Ile Cys Phe Phe Pro Asn Gly Asn 
                325                 330                 335     


Ala Phe Ala Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu 
            340                 345                 350         


Arg Ala Asp Gln Glu Leu Met Thr Tyr Ser His Asp Asn Ile Ile Cys 
        355                 360                 365             


Gly Ile Thr Ser Val Ser Phe Ser Lys Ser Gly Arg Leu Leu Leu Ala 
    370                 375                 380                 


Gly Tyr Asp Asp Phe Asn Cys Asn Val Trp Asp Ala Leu Lys Ala Asp 
385                 390                 395                 400 


Arg Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly 
                405                 410                 415     


Val Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe 
            420                 425                 430         


Leu Lys Ile Trp Asn 
        435         


<210>  2
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Glu Leu Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Arg 
            100                 105                 110         


Asn Gln Ile Arg Asp Ala Arg Lys Ala Cys Gly Asp Ser Thr Leu Thr 
        115                 120                 125             


Gln Ile Thr Ala Gly Leu Asp Pro Val Gly Arg Ile Gln Met Arg Thr 
    130                 135                 140                 


Arg Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp 
145                 150                 155                 160 


Gly Thr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu 
                165                 170                 175     


Ile Ile Trp Asp Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu 
            180                 185                 190         


Arg Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Phe 
        195                 200                 205             


Val Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Ser Leu Lys 
    210                 215                 220                 


Thr Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Pro Gly His Thr 
225                 230                 235                 240 


Gly Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Asn Gln Ile Ile Thr 
                245                 250                 255     


Ser Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln 
            260                 265                 270         


Gln Thr Val Gly Phe Ala Gly His Ser Gly Asp Val Met Ser Leu Ser 
        275                 280                 285             


Leu Ala Pro Asp Gly Arg Thr Phe Val Ser Gly Ala Cys Asp Ala Ser 
    290                 295                 300                 


Ile Lys Leu Trp Asp Val Arg Asp Ser Met Cys Arg Gln Thr Phe Ile 
305                 310                 315                 320 


Gly His Glu Ser Asp Ile Asn Ala Val Ala Phe Phe Pro Asn Gly Tyr 
                325                 330                 335     


Ala Phe Thr Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu 
            340                 345                 350         


Arg Ala Asp Gln Glu Leu Leu Met Tyr Ser His Asp Asn Ile Ile Cys 
        355                 360                 365             


Gly Ile Thr Ser Val Ala Phe Ser Arg Ser Gly Arg Leu Leu Leu Ala 
    370                 375                 380                 


Gly Tyr Asp Asp Phe Asn Cys Asn Ile Trp Asp Ala Met Lys Gly Asp 
385                 390                 395                 400 


Arg Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly 
                405                 410                 415     


Val Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe 
            420                 425                 430         


Leu Lys Ile Trp Asn 
        435         


<210>  3
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Gly Glu Met Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Lys 
            100                 105                 110         


Lys Gln Ile Ala Asp Ala Arg Lys Ala Cys Ala Asp Val Thr Leu Ala 
        115                 120                 125             


Glu Leu Val Ser Gly Leu Glu Val Val Gly Arg Val Gln Met Arg Thr 
    130                 135                 140                 


Arg Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp 
145                 150                 155                 160 


Ala Thr Asp Ser Lys Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu 
                165                 170                 175     


Ile Val Trp Asp Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu 
            180                 185                 190         


Arg Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Phe 
        195                 200                 205             


Val Ala Cys Gly Gly Leu Asp Asn Met Cys Ser Ile Tyr Asn Leu Lys 
    210                 215                 220                 


Ser Arg Glu Gly Asn Val Lys Val Ser Arg Glu Leu Ser Ala His Thr 
225                 230                 235                 240 


Gly Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Asn Asn Ile Val Thr 
                245                 250                 255     


Ser Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln 
            260                 265                 270         


Gln Lys Thr Val Phe Val Gly His Thr Gly Asp Cys Met Ser Leu Ala 
        275                 280                 285             


Val Ser Pro Asp Phe Asn Leu Phe Ile Ser Gly Ala Cys Asp Ala Ser 
    290                 295                 300                 


Ala Lys Leu Trp Asp Val Arg Glu Gly Thr Cys Arg Gln Thr Phe Thr 
305                 310                 315                 320 


Gly His Glu Ser Asp Ile Asn Ala Ile Cys Phe Phe Pro Asn Gly Glu 
                325                 330                 335     


Ala Ile Cys Thr Gly Ser Asp Asp Ala Ser Cys Arg Leu Phe Asp Leu 
            340                 345                 350         


Arg Ala Asp Gln Glu Leu Ile Cys Phe Ser His Glu Ser Ile Ile Cys 
        355                 360                 365             


Gly Ile Thr Ser Val Ala Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala 
    370                 375                 380                 


Gly Tyr Asp Asp Phe Asn Cys Asn Val Trp Asp Ser Met Lys Ser Glu 
385                 390                 395                 400 


Arg Val Gly Ile Leu Ser Gly His Asp Asn Arg Val Ser Cys Leu Gly 
                405                 410                 415     


Val Thr Ala Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe 
            420                 425                 430         


Leu Lys Ile Trp Asn 
        435         


<210>  4
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Glu Leu Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Arg 
            100                 105                 110         


Asn Gln Ile Gln Asp Ala Arg Lys Ala Cys Asn Asp Ala Thr Leu Val 
        115                 120                 125             


Gln Ile Thr Ser Asn Met Asp Ser Val Gly Arg Ile Gln Met Arg Thr 
    130                 135                 140                 


Arg Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp 
145                 150                 155                 160 


Gly Tyr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu 
                165                 170                 175     


Ile Ile Trp Asp Ser Tyr Thr Thr Asn Lys Met His Ala Ile Pro Leu 
            180                 185                 190         


Arg Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Tyr 
        195                 200                 205             


Val Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Asn Leu Lys 
    210                 215                 220                 


Thr Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Pro Gly His Thr 
225                 230                 235                 240 


Gly Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Ser Gln Ile Val Thr 
                245                 250                 255     


Ser Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Ala Gln 
            260                 265                 270         


Gln Thr Thr Thr Phe Thr Gly His Ser Gly Asp Val Met Ser Leu Ser 
        275                 280                 285             


Leu Ser Pro Asp Met Arg Thr Phe Val Ser Gly Ala Cys Asp Ala Ser 
    290                 295                 300                 


Ser Lys Leu Trp Asp Ile Arg Asp Gly Met Cys Arg Gln Ser Phe Thr 
305                 310                 315                 320 


Gly His Val Ser Asp Ile Asn Ala Val Ser Phe Phe Pro Asn Gly Tyr 
                325                 330                 335     


Ala Phe Ala Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu 
            340                 345                 350         


Arg Ala Asp Gln Glu Leu Leu Leu Tyr Ser His Asp Asn Ile Ile Cys 
        355                 360                 365             


Gly Ile Thr Ser Val Ala Phe Ser Lys Ser Gly Arg Leu Leu Leu Ala 
    370                 375                 380                 


Gly Tyr Asp Asp Phe Asn Cys Asn Val Trp Asp Thr Leu Lys Gly Asp 
385                 390                 395                 400 


Arg Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly 
                405                 410                 415     


Val Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe 
            420                 425                 430         


Leu Arg Ile Trp Asn 
        435         


<210>  5
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ala Thr Glu Gly Leu His Glu Asn Glu Thr Leu Ala Ser Leu 
            100                 105                 110         


Lys Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala 
        115                 120                 125             


Lys Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg Val Glu Ala 
    130                 135                 140                 


Leu Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys Gly His Gly 
145                 150                 155                 160 


Asn Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg Arg Ile Val 
                165                 170                 175     


Ser Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser Phe Thr Thr 
            180                 185                 190         


Asn Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val Met Ala Cys 
        195                 200                 205             


Ala Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn 
    210                 215                 220                 


Lys Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu Asn Met Ala 
225                 230                 235                 240 


Ala Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu Ser Ala Cys 
                245                 250                 255     


Ser Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser Gly Asp Gly 
            260                 265                 270         


Thr Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu Gln Ser Phe 
        275                 280                 285             


His Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala Pro Ser Glu 
    290                 295                 300                 


Thr Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys Ala Met Val 
305                 310                 315                 320 


Trp Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu Thr His Glu 
                325                 330                 335     


Ser Asp Ile Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala 
            340                 345                 350         


Ser Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp 
        355                 360                 365             


Arg Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser 
    370                 375                 380                 


Ser Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn 
385                 390                 395                 400 


Asp Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser Arg Val Ser 
                405                 410                 415     


Ile Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg Val Ser Pro 
            420                 425                 430         


Asp Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr Leu Arg Val 
        435                 440                 445             


Trp Ala 
    450 


<210>  6
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Cys Asp Gln Thr Phe Leu Val Asn Val Phe Gly Ser Cys Asp 
            100                 105                 110         


Lys Cys Phe Lys Gln Arg Ala Leu Arg Pro Val Phe Lys Lys Ser Gln 
        115                 120                 125             


Gln Leu Ser Tyr Cys Ser Thr Cys Ala Glu Ile Met Ala Thr Glu Gly 
    130                 135                 140                 


Leu His Glu Asn Glu Thr Leu Ala Ser Leu Lys Ser Glu Ala Glu Ser 
145                 150                 155                 160 


Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala Lys Leu His Asp Val Glu 
                165                 170                 175     


Leu His Gln Val Ala Glu Arg Val Glu Ala Leu Gly Gln Phe Val Met 
            180                 185                 190         


Lys Thr Arg Arg Thr Leu Lys Gly His Gly Asn Lys Val Leu Cys Met 
        195                 200                 205             


Asp Trp Cys Lys Asp Lys Arg Arg Ile Val Ser Ser Ser Gln Asp Gly 
    210                 215                 220                 


Lys Val Ile Val Trp Asp Ser Phe Thr Thr Asn Lys Glu His Ala Val 
225                 230                 235                 240 


Thr Met Pro Cys Thr Trp Val Met Ala Cys Ala Tyr Ala Pro Ser Gly 
                245                 250                 255     


Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn Lys Cys Ser Val Tyr Pro 
            260                 265                 270         


Leu Thr Phe Asp Lys Asn Glu Asn Met Ala Ala Lys Lys Lys Ser Val 
        275                 280                 285             


Ala Met His Thr Asn Tyr Leu Ser Ala Cys Ser Phe Thr Asn Ser Asp 
    290                 295                 300                 


Met Gln Ile Leu Thr Ala Ser Gly Asp Gly Thr Cys Ala Leu Trp Asp 
305                 310                 315                 320 


Val Glu Ser Gly Gln Leu Leu Gln Ser Phe His Gly His Gly Ala Asp 
                325                 330                 335     


Val Leu Cys Leu Asp Leu Ala Pro Ser Glu Thr Gly Asn Thr Phe Val 
            340                 345                 350         


Ser Gly Gly Cys Asp Lys Lys Ala Met Val Trp Asp Met Arg Ser Gly 
        355                 360                 365             


Gln Cys Val Gln Ala Phe Glu Thr His Glu Ser Asp Ile Asn Ser Val 
    370                 375                 380                 


Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala Ser Gly Ser Asp Asp Ala 
385                 390                 395                 400 


Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp Arg Glu Val Ala Ile Tyr 
                405                 410                 415     


Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser Ser Val Asp Phe Ser Leu 
            420                 425                 430         


Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn Asp Tyr Thr Ile Asn Val 
        435                 440                 445             


Trp Asp Val Leu Lys Gly Ser Arg Val Ser Ile Leu Phe Gly His Glu 
    450                 455                 460                 


Asn Arg Val Ser Thr Leu Arg Val Ser Pro Asp Gly Thr Ala Phe Cys 
465                 470                 475                 480 


Ser Gly Ser Trp Asp His Thr Leu Arg Val Trp Ala 
                485                 490         


<210>  7
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Pro Val Ile Asn Ile Glu Asp Leu Thr Glu Lys Asp Lys Leu 
            100                 105                 110         


Lys Met Glu Val Asp Gln Leu Lys Lys Glu Val Thr Leu Glu Arg Met 
        115                 120                 125             


Met Val Ser Lys Cys Cys Glu Glu Val Arg Asp Tyr Ile Glu Glu Arg 
    130                 135                 140                 


Ser Gly Glu Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro 
145                 150                 155                 160 


Phe Lys Glu Leu Lys Gly Gly Cys Val Ile Ser 
                165                 170     


<210>  8
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ala Ser Asn Asn Thr Ala Ser Ile Ala Gln Ala Arg Lys Leu 
            100                 105                 110         


Val Glu Gln Leu Lys Met Glu Ala Asn Ile Asp Arg Ile Lys Val Ser 
        115                 120                 125             


Lys Ala Ala Ala Asp Leu Met Ala Tyr Cys Glu Ala His Ala Lys Glu 
    130                 135                 140                 


Asp Pro Leu Leu Thr Pro Val Pro Ala Ser Glu Asn Pro Phe Arg Glu 
145                 150                 155                 160 


Lys Lys Phe Phe Cys Ala Ile Leu 
                165             


<210>  9
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Lys Gly Glu Thr Pro Val Asn Ser Thr Met Ser Ile Gly Gln 
            100                 105                 110         


Ala Arg Lys Met Val Glu Gln Leu Lys Ile Glu Ala Ser Leu Cys Arg 
        115                 120                 125             


Ile Lys Val Ser Lys Ala Ala Ala Asp Leu Met Thr Tyr Cys Asp Ala 
    130                 135                 140                 


His Ala Cys Glu Asp Pro Leu Ile Thr Pro Val Pro Thr Ser Glu Asn 
145                 150                 155                 160 


Pro Phe Arg Glu Lys Lys Phe Phe Cys Ala Leu Leu 
                165                 170         


<210>  10
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln 
            100                 105                 110         


Ala Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg 
        115                 120                 125             


Val Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala 
    130                 135                 140                 


His Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn 
145                 150                 155                 160 


Pro Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
                165                 170         


<210>  11
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptided

<400>  11

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Gly Ser Ser Ser Val Ala Ala Met Lys Lys Val Val Gln 
            100                 105                 110         


Gln Leu Arg Leu Glu Ala Gly Leu Asn Arg Val Lys Val Ser Gln Ala 
        115                 120                 125             


Ala Ala Asp Leu Lys Gln Phe Cys Leu Gln Asn Ala Gln His Asp Pro 
    130                 135                 140                 


Leu Leu Thr Gly Val Ser Ser Ser Thr Asn Pro Phe Arg Pro Gln Lys 
145                 150                 155                 160 


Val Cys Ser Phe Leu 
                165 


<210>  12
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Ala Thr Asn Asn Ile Ala Gln Ala Arg Lys Leu Val Glu 
            100                 105                 110         


Gln Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala 
        115                 120                 125             


Ala Ser Asp Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro 
    130                 135                 140                 


Leu Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys 
145                 150                 155                 160 


Pro Cys Ile Ile Leu 
                165 


<210>  13
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Asn Asn Met Ala Lys Ile Ala Glu Ala Arg Lys Thr Val 
            100                 105                 110         


Glu Gln Leu Lys Leu Glu Val Asn Ile Asp Arg Met Lys Val Ser Gln 
        115                 120                 125             


Ala Ala Ala Glu Leu Leu Ala Phe Cys Glu Thr His Ala Lys Asp Asp 
    130                 135                 140                 


Pro Leu Val Thr Pro Val Pro Ala Ala Glu Asn Pro Phe Arg Asp Lys 
145                 150                 155                 160 


Arg Leu Phe Cys Val Leu Leu 
                165         


<210>  14
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val 
            100                 105                 110         


Glu Gln Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys 
        115                 120                 125             


Ala Gly Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp 
    130                 135                 140                 


Pro Phe Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys 
145                 150                 155                 160 


Gly Gly Cys Leu Ile Ser 
                165     


<210>  15
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Ser Gly Ala Ser Ala Ser Ala Leu Gln Arg Leu Val Glu 
            100                 105                 110         


Gln Leu Lys Leu Glu Ala Gly Val Glu Arg Ile Lys Val Ser Gln Ala 
        115                 120                 125             


Ala Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala Cys Lys Asp Ala 
    130                 135                 140                 


Leu Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe Arg Glu Pro Arg 
145                 150                 155                 160 


Ser Cys Ala Leu Leu 
                165 


<210>  16
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Pro Ala Leu His Ile Glu Asp Leu Pro Glu Lys Glu Lys Leu 
            100                 105                 110         


Lys Met Glu Val Glu Gln Leu Arg Lys Glu Val Lys Leu Gln Arg Gln 
        115                 120                 125             


Gln Val Ser Lys Cys Ser Glu Glu Ile Lys Asn Tyr Ile Glu Glu Arg 
    130                 135                 140                 


Ser Gly Glu Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro 
145                 150                 155                 160 


Phe Lys Glu Lys Gly Ser Cys Val Ile Ser 
                165                 170 


<210>  17
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Ser Ser Lys Thr Ala Ser Thr Asn Asn Ile Ala Gln Ala Arg 
            100                 105                 110         


Arg Thr Val Gln Gln Leu Arg Leu Glu Ala Ser Ile Glu Arg Ile Lys 
        115                 120                 125             


Val Ser Lys Ala Ser Ala Asp Leu Met Ser Tyr Cys Glu Glu His Ala 
    130                 135                 140                 


Arg Ser Asp Pro Leu Leu Ile Gly Ile Pro Thr Ser Glu Asn Pro Phe 
145                 150                 155                 160 


Lys Asp Lys Lys Thr Cys Ile Ile Leu 
                165                 


<210>  18
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met Gly Asn Gly Gly Asn 
                85                  90                  95      


Ala Met Glu Glu Trp Asp Val Pro Gln Met Lys Lys Glu Val Glu Ser 
            100                 105                 110         


Leu Lys Tyr Gln Leu Ala Phe Gln Arg Glu Met Ala Ser Lys Thr Ile 
        115                 120                 125             


Pro Glu Leu Leu Lys Trp Ile Glu Asp Gly Ile Pro Lys Asp Pro Phe 
    130                 135                 140                 


Leu Asn Pro Asp Leu Met Lys Asn Asn Pro Trp Val Glu Lys Gly Lys 
145                 150                 155                 160 


Cys Thr Ile Leu 
                


<210>  19
<211>  1676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Lys Ile 
            20                  25                  30          


Leu Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Glu 
        35                  40                  45              


Asp Arg Gly Glu Val Thr Phe Glu Lys Ile Phe Ser Gln Lys Leu Gly 
    50                  55                  60                  


Tyr Leu Leu Phe Arg Asp Phe Cys Leu Asn His Leu Glu Glu Ala Arg 
65                  70                  75                  80  


Pro Leu Val Glu Phe Tyr Glu Glu Ile Lys Lys Tyr Glu Lys Leu Glu 
                85                  90                  95      


Thr Glu Glu Glu Arg Val Ala Arg Ser Arg Glu Ile Phe Asp Ser Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ala Cys Ser His Pro Phe Ser Lys Ser Ala 
        115                 120                 125             


Thr Glu His Val Gln Gly His Leu Gly Lys Lys Gln Val Pro Pro Asp 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Gln Asn Leu Arg Gly Asp 
145                 150                 155                 160 


Val Phe Gln Lys Phe Ile Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Asp Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Ser Tyr Ala Phe His Thr Pro Asp Lys Leu Ser Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Ala Asp Met Arg Phe Tyr Ala Ala Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Val Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Val Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Met Ala Val Glu Leu Pro Asp Ser 
                405                 410                 415     


Phe Ser Pro Glu Leu Arg Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Asn Arg Arg Leu Gly Cys Leu Gly Arg Gly Ala Gln Glu Val Lys 
        435                 440                 445             


Glu Ser Pro Phe Phe Arg Ser Leu Asp Trp Gln Met Val Phe Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Ser Asp Gln Glu Leu Tyr Arg Asn Phe Pro Leu Thr 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Ala Glu Thr Val Phe Asp Thr 
        515                 520                 525             


Ile Asn Ala Glu Thr Asp Arg Leu Glu Ala Arg Lys Lys Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Ser Lys Met Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ala Pro Gln Ser Leu Leu Thr Met Glu Glu Ile Gln Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Glu Arg Lys Cys Leu Leu Leu Lys Ile 
    610                 615                 620                 


Arg Gly Gly Lys Gln Phe Ile Leu Gln Cys Asp Ser Asp Pro Glu Leu 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Arg Asp Ala Tyr Arg Glu Ala Gln Gln 
                645                 650                 655     


Leu Val Gln Arg Val Pro Lys Met Lys Asn Lys Pro Arg Ser Pro Val 
            660                 665                 670         


Val Glu Leu Ser Lys Val Pro Leu Val Gln Arg Gly Ser Ala Asn Gly 
        675                 680                 685             


Leu Gly Asn Gly Gly Asn Ala Arg Thr Asp Arg Pro Ser Gln Gln Leu 
    690                 695                 700                 


Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala Pro Glu 
705                 710                 715                 720 


Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala Asp Thr 
                725                 730                 735     


Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr Asp Ala Pro Ile 
            740                 745                 750         


Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro Pro Phe Val Pro 
        755                 760                 765             


Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe Asn Val Asp Glu 
    770                 775                 780                 


Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe Asp Gly Val Asn 
785                 790                 795                 800 


Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val Gly Tyr Gly Gln 
                805                 810                 815     


Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala Phe Leu Arg Ala 
            820                 825                 830         


Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp Ser Asp Gly Ser 
        835                 840                 845             


Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly Ile Phe Arg Asp 
    850                 855                 860                 


Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser Asp Phe His Val 
865                 870                 875                 880 


Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val Leu Glu Ala Glu 
                885                 890                 895     


Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg Val Thr Val Ser 
            900                 905                 910         


Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr Ala Pro Phe Gly 
        915                 920                 925             


Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp Arg Val Thr Leu 
    930                 935                 940                 


Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala Glu Ile Pro Asn 
945                 950                 955                 960 


Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp Gly Thr Leu Ile 
                965                 970                 975     


Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val Arg Ile Glu Asn 
            980                 985                 990         


Gly Leu Leu Leu Leu Asn Gly Lys  Pro Leu Leu Ile Arg  Gly Val Asn 
        995                 1000                 1005             


Arg His  Glu His His Pro Leu  His Gly Gln Val Met  Asp Glu Gln 
    1010                 1015                 1020             


Thr Met  Val Gln Asp Ile Leu  Leu Met Lys Gln Asn  Asn Phe Asn 
    1025                 1030                 1035             


Ala Val  Arg Cys Ser His Tyr  Pro Asn His Pro Leu  Trp Tyr Thr 
    1040                 1045                 1050             


Leu Cys  Asp Arg Tyr Gly Leu  Tyr Val Val Asp Glu  Ala Asn Ile 
    1055                 1060                 1065             


Glu Thr  His Gly Met Val Pro  Met Asn Arg Leu Thr  Asp Asp Pro 
    1070                 1075                 1080             


Arg Trp  Leu Pro Ala Met Ser  Glu Arg Val Thr Arg  Met Val Gln 
    1085                 1090                 1095             


Arg Asp  Arg Asn His Pro Ser  Val Ile Ile Trp Ser  Leu Gly Asn 
    1100                 1105                 1110             


Glu Ser  Gly His Gly Ala Asn  His Asp Ala Leu Tyr  Arg Trp Ile 
    1115                 1120                 1125             


Lys Ser  Val Asp Pro Ser Arg  Pro Val Gln Tyr Glu  Gly Gly Gly 
    1130                 1135                 1140             


Ala Asp  Thr Thr Ala Thr Asp  Ile Ile Cys Pro Met  Tyr Ala Arg 
    1145                 1150                 1155             


Val Asp  Glu Asp Gln Pro Phe  Pro Ala Val Pro Lys  Trp Ser Ile 
    1160                 1165                 1170             


Lys Lys  Trp Leu Ser Leu Pro  Gly Glu Thr Arg Pro  Leu Ile Leu 
    1175                 1180                 1185             


Cys Glu  Tyr Ala His Ala Met  Gly Asn Ser Leu Gly  Gly Phe Ala 
    1190                 1195                 1200             


Lys Tyr  Trp Gln Ala Phe Arg  Gln Tyr Pro Arg Leu  Gln Gly Gly 
    1205                 1210                 1215             


Phe Val  Trp Asp Trp Val Asp  Gln Ser Leu Ile Lys  Tyr Asp Glu 
    1220                 1225                 1230             


Asn Gly  Asn Pro Trp Ser Ala  Tyr Gly Gly Asp Phe  Gly Asp Thr 
    1235                 1240                 1245             


Pro Asn  Asp Arg Gln Phe Cys  Met Asn Gly Leu Val  Phe Ala Asp 
    1250                 1255                 1260             


Arg Thr  Pro His Pro Ala Leu  Thr Glu Ala Lys His  Gln Gln Gln 
    1265                 1270                 1275             


Phe Phe  Gln Phe Arg Leu Ser  Gly Gln Thr Ile Glu  Val Thr Ser 
    1280                 1285                 1290             


Glu Tyr  Leu Phe Arg His Ser  Asp Asn Glu Leu Leu  His Trp Met 
    1295                 1300                 1305             


Val Ala  Leu Asp Gly Lys Pro  Leu Ala Ser Gly Glu  Val Pro Leu 
    1310                 1315                 1320             


Asp Val  Ala Pro Gln Gly Lys  Gln Leu Ile Glu Leu  Pro Glu Leu 
    1325                 1330                 1335             


Pro Gln  Pro Glu Ser Ala Gly  Gln Leu Trp Leu Thr  Val Arg Val 
    1340                 1345                 1350             


Val Gln  Pro Asn Ala Thr Ala  Trp Ser Glu Ala Gly  His Ile Ser 
    1355                 1360                 1365             


Ala Trp  Gln Gln Trp Arg Leu  Ala Glu Asn Leu Ser  Val Thr Leu 
    1370                 1375                 1380             


Pro Ala  Ala Ser His Ala Ile  Pro His Leu Thr Thr  Ser Glu Met 
    1385                 1390                 1395             


Asp Phe  Cys Ile Glu Leu Gly  Asn Lys Arg Trp Gln  Phe Asn Arg 
    1400                 1405                 1410             


Gln Ser  Gly Phe Leu Ser Gln  Met Trp Ile Gly Asp  Lys Lys Gln 
    1415                 1420                 1425             


Leu Leu  Thr Pro Leu Arg Asp  Gln Phe Thr Arg Ala  Pro Leu Asp 
    1430                 1435                 1440             


Asn Asp  Ile Gly Val Ser Glu  Ala Thr Arg Ile Asp  Pro Asn Ala 
    1445                 1450                 1455             


Trp Val  Glu Arg Trp Lys Ala  Ala Gly His Tyr Gln  Ala Glu Ala 
    1460                 1465                 1470             


Ala Leu  Leu Gln Cys Thr Ala  Asp Thr Leu Ala Asp  Ala Val Leu 
    1475                 1480                 1485             


Ile Thr  Thr Ala His Ala Trp  Gln His Gln Gly Lys  Thr Leu Phe 
    1490                 1495                 1500             


Ile Ser  Arg Lys Thr Tyr Arg  Ile Asp Gly Ser Gly  Gln Met Ala 
    1505                 1510                 1515             


Ile Thr  Val Asp Val Glu Val  Ala Ser Asp Thr Pro  His Pro Ala 
    1520                 1525                 1530             


Arg Ile  Gly Leu Asn Cys Gln  Leu Ala Gln Val Ala  Glu Arg Val 
    1535                 1540                 1545             


Asn Trp  Leu Gly Leu Gly Pro  Gln Glu Asn Tyr Pro  Asp Arg Leu 
    1550                 1555                 1560             


Thr Ala  Ala Cys Phe Asp Arg  Trp Asp Leu Pro Leu  Ser Asp Met 
    1565                 1570                 1575             


Tyr Thr  Pro Tyr Val Phe Pro  Ser Glu Asn Gly Leu  Arg Cys Gly 
    1580                 1585                 1590             


Thr Arg  Glu Leu Asn Tyr Gly  Pro His Gln Trp Arg  Gly Asp Phe 
    1595                 1600                 1605             


Gln Phe  Asn Ile Ser Arg Tyr  Ser Gln Gln Gln Leu  Met Glu Thr 
    1610                 1615                 1620             


Ser His  Arg His Leu Leu His  Ala Glu Glu Gly Thr  Trp Leu Asn 
    1625                 1630                 1635             


Ile Asp  Gly Phe His Met Gly  Ile Gly Gly Asp Asp  Ser Trp Ser 
    1640                 1645                 1650             


Pro Ser  Val Ser Ala Glu Phe  Gln Leu Ser Ala Gly  Arg Tyr His 
    1655                 1660                 1665             


Tyr Gln  Leu Val Trp Cys Gln  Lys 
    1670                 1675     


<210>  20
<211>  1217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Met Gly Asn Gly Gly Asn Ala Pro Pro Pro Leu Ile Pro Pro Arg Gly 
1               5                   10                  15      


Glu Val Asn Ala Ala Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu 
            20                  25                  30          


Asp Thr Lys Gly Ile Lys Leu Leu Asp Ser Asp Gln Glu Leu Tyr Arg 
        35                  40                  45              


Asn Phe Pro Leu Thr Ile Ser Glu Arg Trp Gln Gln Glu Val Ala Glu 
    50                  55                  60                  


Thr Val Phe Asp Thr Ile Asn Ala Glu Thr Asp Arg Leu Glu Ala Arg 
65                  70                  75                  80  


Lys Lys Ala Lys Asn Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu 
                85                  90                  95      


Gly Lys Asp Cys Ile Met His Gly Tyr Met Ser Lys Met Gly Asn Pro 
            100                 105                 110         


Phe Leu Thr Gln Trp Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg 
        115                 120                 125             


Leu Glu Trp Arg Gly Glu Gly Glu Ala Pro Gln Ser Leu Leu Thr Met 
    130                 135                 140                 


Glu Glu Ile Gln Ser Val Glu Glu Thr Gln Ile Lys Glu Arg Lys Cys 
145                 150                 155                 160 


Leu Leu Leu Lys Ile Arg Gly Gly Lys Gln Phe Ile Leu Gln Cys Asp 
                165                 170                 175     


Ser Asp Pro Glu Leu Val Gln Trp Lys Lys Glu Leu Arg Asp Ala Tyr 
            180                 185                 190         


Arg Glu Ala Gln Gln Leu Val Gln Arg Val Pro Lys Met Lys Asn Lys 
        195                 200                 205             


Pro Arg Ser Pro Val Val Glu Leu Ser Lys Val Pro Leu Val Gln Arg 
    210                 215                 220                 


Gly Ser Ala Asn Gly Leu Gly Asn Gly Gly Asn Ala Arg Thr Asp Arg 
225                 230                 235                 240 


Pro Ser Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp 
                245                 250                 255     


Phe Pro Ala Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu 
            260                 265                 270         


Pro Glu Ala Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly 
        275                 280                 285             


Tyr Asp Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn 
    290                 295                 300                 


Pro Pro Phe Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr 
305                 310                 315                 320 


Phe Asn Val Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile 
                325                 330                 335     


Phe Asp Gly Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp 
            340                 345                 350         


Val Gly Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser 
        355                 360                 365             


Ala Phe Leu Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg 
    370                 375                 380                 


Trp Ser Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser 
385                 390                 395                 400 


Gly Ile Phe Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile 
                405                 410                 415     


Ser Asp Phe His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala 
            420                 425                 430         


Val Leu Glu Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu 
        435                 440                 445             


Arg Val Thr Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly 
    450                 455                 460                 


Thr Ala Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala 
465                 470                 475                 480 


Asp Arg Val Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser 
                485                 490                 495     


Ala Glu Ile Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala 
            500                 505                 510         


Asp Gly Thr Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu 
        515                 520                 525             


Val Arg Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu 
    530                 535                 540                 


Ile Arg Gly Val Asn Arg His Glu His His Pro Leu His Gly Gln Val 
545                 550                 555                 560 


Met Asp Glu Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn 
                565                 570                 575     


Asn Phe Asn Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp 
            580                 585                 590         


Tyr Thr Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn 
        595                 600                 605             


Ile Glu Thr His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro 
    610                 615                 620                 


Arg Trp Leu Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg 
625                 630                 635                 640 


Asp Arg Asn His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser 
                645                 650                 655     


Gly His Gly Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val 
            660                 665                 670         


Asp Pro Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr 
        675                 680                 685             


Ala Thr Asp Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln 
    690                 695                 700                 


Pro Phe Pro Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu 
705                 710                 715                 720 


Pro Gly Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met 
                725                 730                 735     


Gly Asn Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln 
            740                 745                 750         


Tyr Pro Arg Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser 
        755                 760                 765             


Leu Ile Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly 
    770                 775                 780                 


Asp Phe Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu 
785                 790                 795                 800 


Val Phe Ala Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His 
                805                 810                 815     


Gln Gln Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val 
            820                 825                 830         


Thr Ser Glu Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp 
        835                 840                 845             


Met Val Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu 
    850                 855                 860                 


Asp Val Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro 
865                 870                 875                 880 


Gln Pro Glu Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln 
                885                 890                 895     


Pro Asn Ala Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln 
            900                 905                 910         


Gln Trp Arg Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser 
        915                 920                 925             


His Ala Ile Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu 
    930                 935                 940                 


Leu Gly Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser 
945                 950                 955                 960 


Gln Met Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp 
                965                 970                 975     


Gln Phe Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala 
            980                 985                 990         


Thr Arg Ile Asp Pro Asn Ala Trp  Val Glu Arg Trp Lys  Ala Ala Gly 
        995                 1000                 1005             


His Tyr  Gln Ala Glu Ala Ala  Leu Leu Gln Cys Thr  Ala Asp Thr 
    1010                 1015                 1020             


Leu Ala  Asp Ala Val Leu Ile  Thr Thr Ala His Ala  Trp Gln His 
    1025                 1030                 1035             


Gln Gly  Lys Thr Leu Phe Ile  Ser Arg Lys Thr Tyr  Arg Ile Asp 
    1040                 1045                 1050             


Gly Ser  Gly Gln Met Ala Ile  Thr Val Asp Val Glu  Val Ala Ser 
    1055                 1060                 1065             


Asp Thr  Pro His Pro Ala Arg  Ile Gly Leu Asn Cys  Gln Leu Ala 
    1070                 1075                 1080             


Gln Val  Ala Glu Arg Val Asn  Trp Leu Gly Leu Gly  Pro Gln Glu 
    1085                 1090                 1095             


Asn Tyr  Pro Asp Arg Leu Thr  Ala Ala Cys Phe Asp  Arg Trp Asp 
    1100                 1105                 1110             


Leu Pro  Leu Ser Asp Met Tyr  Thr Pro Tyr Val Phe  Pro Ser Glu 
    1115                 1120                 1125             


Asn Gly  Leu Arg Cys Gly Thr  Arg Glu Leu Asn Tyr  Gly Pro His 
    1130                 1135                 1140             


Gln Trp  Arg Gly Asp Phe Gln  Phe Asn Ile Ser Arg  Tyr Ser Gln 
    1145                 1150                 1155             


Gln Gln  Leu Met Glu Thr Ser  His Arg His Leu Leu  His Ala Glu 
    1160                 1165                 1170             


Glu Gly  Thr Trp Leu Asn Ile  Asp Gly Phe His Met  Gly Ile Gly 
    1175                 1180                 1185             


Gly Asp  Asp Ser Trp Ser Pro  Ser Val Ser Ala Glu  Phe Gln Leu 
    1190                 1195                 1200             


Ser Ala  Gly Arg Tyr His Tyr  Gln Leu Val Trp Cys  Gln Lys 
    1205                 1210                 1215         


<210>  21
<211>  1675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Arg Ile 
            20                  25                  30          


Val Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Ala 
        35                  40                  45              


Glu Arg Asn Glu Ile Thr Phe Asp Lys Ile Phe Asn Gln Lys Ile Gly 
    50                  55                  60                  


Phe Leu Leu Phe Lys Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val 
65                  70                  75                  80  


Pro Gln Val Lys Phe Tyr Glu Glu Ile Lys Glu Tyr Glu Lys Leu Asp 
                85                  90                  95      


Asn Glu Glu Asp Arg Leu Cys Arg Ser Arg Gln Ile Tyr Asp Ala Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ser Cys Ser His Pro Phe Ser Lys Gln Ala 
        115                 120                 125             


Val Glu His Val Gln Ser His Leu Ser Lys Lys Gln Val Thr Ser Thr 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Glu Ser Leu Arg Gly Asp 
145                 150                 155                 160 


Ile Phe Gln Lys Phe Met Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Glu Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Thr Tyr Ala Phe His Thr Pro Asp Lys Leu Cys Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Lys Glu Met Arg Phe Tyr Ala Thr Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Ala Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Thr Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Val Asn Val Glu Leu Pro Asp Thr 
                405                 410                 415     


Phe Ser Pro Glu Leu Lys Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Ser Lys Arg Leu Gly Cys His Gly Gly Gly Ser Gln Glu Val Lys 
        435                 440                 445             


Glu His Ser Phe Phe Lys Gly Val Asp Trp Gln His Val Tyr Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Cys Asp Gln Glu Leu Tyr Lys Asn Phe Pro Leu Val 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Thr Glu Thr Val Tyr Glu Ala 
        515                 520                 525             


Val Asn Ala Asp Thr Asp Lys Ile Glu Ala Arg Lys Arg Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Leu Lys Leu Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ser Arg Gln Asn Leu Leu Thr Met Glu Gln Ile Leu Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Asp Lys Lys Cys Ile Leu Phe Arg Ile 
    610                 615                 620                 


Lys Gly Gly Lys Gln Phe Val Leu Gln Cys Glu Ser Asp Pro Glu Phe 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Asn Glu Thr Phe Lys Glu Ala Gln Arg 
                645                 650                 655     


Leu Leu Arg Arg Ala Pro Lys Phe Leu Asn Lys Pro Arg Ser Gly Thr 
            660                 665                 670         


Val Glu Leu Pro Lys Pro Ser Leu Cys His Arg Asn Ser Asn Gly Leu 
        675                 680                 685             


Gly Asn Gly Gly Asn Ala Arg Thr Asp Arg Pro Ser Gln Gln Leu Arg 
    690                 695                 700                 


Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala Pro Glu Ala 
705                 710                 715                 720 


Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala Asp Thr Val 
                725                 730                 735     


Val Val Pro Ser Asn Trp Gln Met His Gly Tyr Asp Ala Pro Ile Tyr 
            740                 745                 750         


Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro Pro Phe Val Pro Thr 
        755                 760                 765             


Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe Asn Val Asp Glu Ser 
    770                 775                 780                 


Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe Asp Gly Val Asn Ser 
785                 790                 795                 800 


Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val Gly Tyr Gly Gln Asp 
                805                 810                 815     


Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala Phe Leu Arg Ala Gly 
            820                 825                 830         


Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp Ser Asp Gly Ser Tyr 
        835                 840                 845             


Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly Ile Phe Arg Asp Val 
    850                 855                 860                 


Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser Asp Phe His Val Ala 
865                 870                 875                 880 


Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val Leu Glu Ala Glu Val 
                885                 890                 895     


Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg Val Thr Val Ser Leu 
            900                 905                 910         


Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr Ala Pro Phe Gly Gly 
        915                 920                 925             


Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp Arg Val Thr Leu Arg 
    930                 935                 940                 


Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala Glu Ile Pro Asn Leu 
945                 950                 955                 960 


Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp Gly Thr Leu Ile Glu 
                965                 970                 975     


Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val Arg Ile Glu Asn Gly 
            980                 985                 990         


Leu Leu Leu Leu Asn Gly Lys Pro  Leu Leu Ile Arg Gly  Val Asn Arg 
        995                 1000                 1005             


His Glu  His His Pro Leu His  Gly Gln Val Met Asp  Glu Gln Thr 
    1010                 1015                 1020             


Met Val  Gln Asp Ile Leu Leu  Met Lys Gln Asn Asn  Phe Asn Ala 
    1025                 1030                 1035             


Val Arg  Cys Ser His Tyr Pro  Asn His Pro Leu Trp  Tyr Thr Leu 
    1040                 1045                 1050             


Cys Asp  Arg Tyr Gly Leu Tyr  Val Val Asp Glu Ala  Asn Ile Glu 
    1055                 1060                 1065             


Thr His  Gly Met Val Pro Met  Asn Arg Leu Thr Asp  Asp Pro Arg 
    1070                 1075                 1080             


Trp Leu  Pro Ala Met Ser Glu  Arg Val Thr Arg Met  Val Gln Arg 
    1085                 1090                 1095             


Asp Arg  Asn His Pro Ser Val  Ile Ile Trp Ser Leu  Gly Asn Glu 
    1100                 1105                 1110             


Ser Gly  His Gly Ala Asn His  Asp Ala Leu Tyr Arg  Trp Ile Lys 
    1115                 1120                 1125             


Ser Val  Asp Pro Ser Arg Pro  Val Gln Tyr Glu Gly  Gly Gly Ala 
    1130                 1135                 1140             


Asp Thr  Thr Ala Thr Asp Ile  Ile Cys Pro Met Tyr  Ala Arg Val 
    1145                 1150                 1155             


Asp Glu  Asp Gln Pro Phe Pro  Ala Val Pro Lys Trp  Ser Ile Lys 
    1160                 1165                 1170             


Lys Trp  Leu Ser Leu Pro Gly  Glu Thr Arg Pro Leu  Ile Leu Cys 
    1175                 1180                 1185             


Glu Tyr  Ala His Ala Met Gly  Asn Ser Leu Gly Gly  Phe Ala Lys 
    1190                 1195                 1200             


Tyr Trp  Gln Ala Phe Arg Gln  Tyr Pro Arg Leu Gln  Gly Gly Phe 
    1205                 1210                 1215             


Val Trp  Asp Trp Val Asp Gln  Ser Leu Ile Lys Tyr  Asp Glu Asn 
    1220                 1225                 1230             


Gly Asn  Pro Trp Ser Ala Tyr  Gly Gly Asp Phe Gly  Asp Thr Pro 
    1235                 1240                 1245             


Asn Asp  Arg Gln Phe Cys Met  Asn Gly Leu Val Phe  Ala Asp Arg 
    1250                 1255                 1260             


Thr Pro  His Pro Ala Leu Thr  Glu Ala Lys His Gln  Gln Gln Phe 
    1265                 1270                 1275             


Phe Gln  Phe Arg Leu Ser Gly  Gln Thr Ile Glu Val  Thr Ser Glu 
    1280                 1285                 1290             


Tyr Leu  Phe Arg His Ser Asp  Asn Glu Leu Leu His  Trp Met Val 
    1295                 1300                 1305             


Ala Leu  Asp Gly Lys Pro Leu  Ala Ser Gly Glu Val  Pro Leu Asp 
    1310                 1315                 1320             


Val Ala  Pro Gln Gly Lys Gln  Leu Ile Glu Leu Pro  Glu Leu Pro 
    1325                 1330                 1335             


Gln Pro  Glu Ser Ala Gly Gln  Leu Trp Leu Thr Val  Arg Val Val 
    1340                 1345                 1350             


Gln Pro  Asn Ala Thr Ala Trp  Ser Glu Ala Gly His  Ile Ser Ala 
    1355                 1360                 1365             


Trp Gln  Gln Trp Arg Leu Ala  Glu Asn Leu Ser Val  Thr Leu Pro 
    1370                 1375                 1380             


Ala Ala  Ser His Ala Ile Pro  His Leu Thr Thr Ser  Glu Met Asp 
    1385                 1390                 1395             


Phe Cys  Ile Glu Leu Gly Asn  Lys Arg Trp Gln Phe  Asn Arg Gln 
    1400                 1405                 1410             


Ser Gly  Phe Leu Ser Gln Met  Trp Ile Gly Asp Lys  Lys Gln Leu 
    1415                 1420                 1425             


Leu Thr  Pro Leu Arg Asp Gln  Phe Thr Arg Ala Pro  Leu Asp Asn 
    1430                 1435                 1440             


Asp Ile  Gly Val Ser Glu Ala  Thr Arg Ile Asp Pro  Asn Ala Trp 
    1445                 1450                 1455             


Val Glu  Arg Trp Lys Ala Ala  Gly His Tyr Gln Ala  Glu Ala Ala 
    1460                 1465                 1470             


Leu Leu  Gln Cys Thr Ala Asp  Thr Leu Ala Asp Ala  Val Leu Ile 
    1475                 1480                 1485             


Thr Thr  Ala His Ala Trp Gln  His Gln Gly Lys Thr  Leu Phe Ile 
    1490                 1495                 1500             


Ser Arg  Lys Thr Tyr Arg Ile  Asp Gly Ser Gly Gln  Met Ala Ile 
    1505                 1510                 1515             


Thr Val  Asp Val Glu Val Ala  Ser Asp Thr Pro His  Pro Ala Arg 
    1520                 1525                 1530             


Ile Gly  Leu Asn Cys Gln Leu  Ala Gln Val Ala Glu  Arg Val Asn 
    1535                 1540                 1545             


Trp Leu  Gly Leu Gly Pro Gln  Glu Asn Tyr Pro Asp  Arg Leu Thr 
    1550                 1555                 1560             


Ala Ala  Cys Phe Asp Arg Trp  Asp Leu Pro Leu Ser  Asp Met Tyr 
    1565                 1570                 1575             


Thr Pro  Tyr Val Phe Pro Ser  Glu Asn Gly Leu Arg  Cys Gly Thr 
    1580                 1585                 1590             


Arg Glu  Leu Asn Tyr Gly Pro  His Gln Trp Arg Gly  Asp Phe Gln 
    1595                 1600                 1605             


Phe Asn  Ile Ser Arg Tyr Ser  Gln Gln Gln Leu Met  Glu Thr Ser 
    1610                 1615                 1620             


His Arg  His Leu Leu His Ala  Glu Glu Gly Thr Trp  Leu Asn Ile 
    1625                 1630                 1635             


Asp Gly  Phe His Met Gly Ile  Gly Gly Asp Asp Ser  Trp Ser Pro 
    1640                 1645                 1650             


Ser Val  Ser Ala Glu Phe Gln  Leu Ser Ala Gly Arg  Tyr His Tyr 
    1655                 1660                 1665             


Gln Leu  Val Trp Cys Gln Lys  
    1670                 1675 


<210>  22
<211>  1216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Met Gly Asn Gly Gly Asn Ala Pro Pro Pro Leu Ile Pro Pro Arg Gly 
1               5                   10                  15      


Glu Val Asn Ala Ala Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu 
            20                  25                  30          


Asp Thr Lys Gly Ile Lys Leu Leu Asp Cys Asp Gln Glu Leu Tyr Lys 
        35                  40                  45              


Asn Phe Pro Leu Val Ile Ser Glu Arg Trp Gln Gln Glu Val Thr Glu 
    50                  55                  60                  


Thr Val Tyr Glu Ala Val Asn Ala Asp Thr Asp Lys Ile Glu Ala Arg 
65                  70                  75                  80  


Lys Arg Ala Lys Asn Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu 
                85                  90                  95      


Gly Lys Asp Cys Ile Met His Gly Tyr Met Leu Lys Leu Gly Asn Pro 
            100                 105                 110         


Phe Leu Thr Gln Trp Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg 
        115                 120                 125             


Leu Glu Trp Arg Gly Glu Gly Glu Ser Arg Gln Asn Leu Leu Thr Met 
    130                 135                 140                 


Glu Gln Ile Leu Ser Val Glu Glu Thr Gln Ile Lys Asp Lys Lys Cys 
145                 150                 155                 160 


Ile Leu Phe Arg Ile Lys Gly Gly Lys Gln Phe Val Leu Gln Cys Glu 
                165                 170                 175     


Ser Asp Pro Glu Phe Val Gln Trp Lys Lys Glu Leu Asn Glu Thr Phe 
            180                 185                 190         


Lys Glu Ala Gln Arg Leu Leu Arg Arg Ala Pro Lys Phe Leu Asn Lys 
        195                 200                 205             


Pro Arg Ser Gly Thr Val Glu Leu Pro Lys Pro Ser Leu Cys His Arg 
    210                 215                 220                 


Asn Ser Asn Gly Leu Gly Asn Gly Gly Asn Ala Arg Thr Asp Arg Pro 
225                 230                 235                 240 


Ser Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe 
                245                 250                 255     


Pro Ala Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro 
            260                 265                 270         


Glu Ala Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr 
        275                 280                 285             


Asp Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro 
    290                 295                 300                 


Pro Phe Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe 
305                 310                 315                 320 


Asn Val Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe 
                325                 330                 335     


Asp Gly Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val 
            340                 345                 350         


Gly Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala 
        355                 360                 365             


Phe Leu Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp 
    370                 375                 380                 


Ser Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly 
385                 390                 395                 400 


Ile Phe Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser 
                405                 410                 415     


Asp Phe His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val 
            420                 425                 430         


Leu Glu Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg 
        435                 440                 445             


Val Thr Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr 
    450                 455                 460                 


Ala Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp 
465                 470                 475                 480 


Arg Val Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala 
                485                 490                 495     


Glu Ile Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp 
            500                 505                 510         


Gly Thr Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val 
        515                 520                 525             


Arg Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile 
    530                 535                 540                 


Arg Gly Val Asn Arg His Glu His His Pro Leu His Gly Gln Val Met 
545                 550                 555                 560 


Asp Glu Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn 
                565                 570                 575     


Phe Asn Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr 
            580                 585                 590         


Thr Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile 
        595                 600                 605             


Glu Thr His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg 
    610                 615                 620                 


Trp Leu Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp 
625                 630                 635                 640 


Arg Asn His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly 
                645                 650                 655     


His Gly Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp 
            660                 665                 670         


Pro Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala 
        675                 680                 685             


Thr Asp Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro 
    690                 695                 700                 


Phe Pro Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro 
705                 710                 715                 720 


Gly Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly 
                725                 730                 735     


Asn Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr 
            740                 745                 750         


Pro Arg Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu 
        755                 760                 765             


Ile Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp 
    770                 775                 780                 


Phe Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val 
785                 790                 795                 800 


Phe Ala Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His Gln 
                805                 810                 815     


Gln Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr 
            820                 825                 830         


Ser Glu Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp Met 
        835                 840                 845             


Val Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp 
    850                 855                 860                 


Val Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln 
865                 870                 875                 880 


Pro Glu Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro 
                885                 890                 895     


Asn Ala Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln 
            900                 905                 910         


Trp Arg Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His 
        915                 920                 925             


Ala Ile Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu 
    930                 935                 940                 


Gly Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln 
945                 950                 955                 960 


Met Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln 
                965                 970                 975     


Phe Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr 
            980                 985                 990         


Arg Ile Asp Pro Asn Ala Trp Val  Glu Arg Trp Lys Ala  Ala Gly His 
        995                 1000                 1005             


Tyr Gln  Ala Glu Ala Ala Leu  Leu Gln Cys Thr Ala  Asp Thr Leu 
    1010                 1015                 1020             


Ala Asp  Ala Val Leu Ile Thr  Thr Ala His Ala Trp  Gln His Gln 
    1025                 1030                 1035             


Gly Lys  Thr Leu Phe Ile Ser  Arg Lys Thr Tyr Arg  Ile Asp Gly 
    1040                 1045                 1050             


Ser Gly  Gln Met Ala Ile Thr  Val Asp Val Glu Val  Ala Ser Asp 
    1055                 1060                 1065             


Thr Pro  His Pro Ala Arg Ile  Gly Leu Asn Cys Gln  Leu Ala Gln 
    1070                 1075                 1080             


Val Ala  Glu Arg Val Asn Trp  Leu Gly Leu Gly Pro  Gln Glu Asn 
    1085                 1090                 1095             


Tyr Pro  Asp Arg Leu Thr Ala  Ala Cys Phe Asp Arg  Trp Asp Leu 
    1100                 1105                 1110             


Pro Leu  Ser Asp Met Tyr Thr  Pro Tyr Val Phe Pro  Ser Glu Asn 
    1115                 1120                 1125             


Gly Leu  Arg Cys Gly Thr Arg  Glu Leu Asn Tyr Gly  Pro His Gln 
    1130                 1135                 1140             


Trp Arg  Gly Asp Phe Gln Phe  Asn Ile Ser Arg Tyr  Ser Gln Gln 
    1145                 1150                 1155             


Gln Leu  Met Glu Thr Ser His  Arg His Leu Leu His  Ala Glu Glu 
    1160                 1165                 1170             


Gly Thr  Trp Leu Asn Ile Asp  Gly Phe His Met Gly  Ile Gly Gly 
    1175                 1180                 1185             


Asp Asp  Ser Trp Ser Pro Ser  Val Ser Ala Glu Phe  Gln Leu Ser 
    1190                 1195                 1200             


Ala Gly  Arg Tyr His Tyr Gln  Leu Val Trp Cys Gln  Lys 
    1205                 1210                 1215     


<210>  23
<211>  5424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg      660

cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata      720

agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac      780

agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt      840

gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa      900

ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact      960

cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac     1020

aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact     1080

ataggctagc gccaccgcgg ccgggcggcc gcttcgagca gacatgataa gatacattga     1140

tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg     1200

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     1260

ttgcattcat tttatgtttc aggttcaggg ggagatgtgg gaggtttttt aaagcaagta     1320

aaacctctac aaatgtggta aaatccgata aggatcgatc cgggctggcg taatagcgaa     1380

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggacgcgc     1440

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     1500

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     1560

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     1620

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     1680

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     1740

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     1800

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     1860

attttaacaa aatattaacg cttacaattt cctgatgcgg tattttctcc ttacgcatct     1920

gtgcggtatt tcacaccgca tacgcggatc tgcgcagcac catggcctga aataacctct     1980

gaaagaggaa cttggttagg taccttctga ggcggaaaga accagctgtg gaatgtgtgt     2040

cagttagggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     2100

ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg     2160

caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg     2220

cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt     2280

tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt     2340

tttggaggcc taggcttttg caaaaagctt gattcttctg acacaacagt ctcgaactta     2400

aggctagagc caccatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     2460

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     2520

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     2580

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     2640

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     2700

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     2760

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     2820

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg     2880

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg     2940

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata     3000

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg     3060

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat     3120

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct     3180

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca     3240

agcgacgccc aacctgccat cacgatggcc gcaataaaat atctttattt tcattacatc     3300

tgtgtgttgg ttttttgtgt gaatcgatag cgataaggat ccgcgtatgg tgcactctca     3360

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg     3420

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     3480

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     3540

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt     3600

caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     3660

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     3720

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     3780

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     3840

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     3900

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     3960

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     4020

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     4080

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     4140

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     4200

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     4260

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     4320

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     4380

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     4440

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     4500

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     4560

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     4620

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     4680

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     4740

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     4800

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     4860

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     4920

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     4980

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     5040

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     5100

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     5160

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     5220

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     5280

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     5340

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     5400

ttgctcacat ggctcgacag atct                                            5424


<210>  24
<211>  6738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg      660

cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata      720

agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac      780

agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt      840

gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa      900

ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact      960

cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac     1020

aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact     1080

ataggctagc gccaccatga ttacggattc actggccgtc gttttacaac gtcgtgactg     1140

ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg     1200

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg     1260

cgaatggcgc tttgcctggt ttccggcacc agaagcggtg ccggaaagct ggctggagtg     1320

cgatcttcct gaggccgata ctgtcgtcgt cccctcaaac tggcagatgg gaaacggggg     1380

aaacgcaatg agtgagcttg accagttacg gcaggaggcc gagcaactta agaaccagat     1440

tcgagacgcc aggaaagcat gtgcagatgc aactctctct cagatcacaa acaacatcga     1500

cccagtggga agaatccaaa tgcgcacgag gaggacactg cgggggcacc tggccaagat     1560

ctacgccatg cactggggca cagactccag gcttctcgtc agtgcctcgc aggatggtaa     1620

acttatcatc tgggacagct acaccaccaa caaggtccac gccatccctc tgcgctcctc     1680

ctgggtcatg acctgtgcat atgccccttc tgggaactat gtggcctgcg gtggcctgga     1740

taacatttgc tccatttaca atctgaaaac tcgtgagggg aacgtgcgcg tgagtcgtga     1800

gctggcagga cacacaggtt acctgtcctg ctgccgattc ctggatgaca atcagatcgt     1860

caccagctct ggagacacca cgtgtgccct gtgggacatc gagaccggcc agcagacgac     1920

cacgtttacc ggacacactg gagatgtcat gagcctttct cttgctcctg acaccagact     1980

gttcgtctct ggtgcttgtg atgcttcagc caaactctgg gatgtgcgag aaggcatgtg     2040

ccggcagacc ttcactggcc acgagtctga catcaatgcc atttgcttct ttccaaatgg     2100

caatgcattt gccactggct cagacgacgc cacctgcagg ctgtttgacc ttcgtgctga     2160

ccaggagctc atgacttact cccatgacaa catcatctgc gggatcacct ctgtctcctt     2220

ctccaagagc gggcgcctcc tccttgctgg gtacgacgac ttcaactgca acgtctggga     2280

tgcactcaaa gccgaccggg caggtgtctt ggctgggcat gacaaccgcg tcagctgcct     2340

gggcgtgact gacgatggca tggctgtggc gacagggtcc tgggatagct tcctcaagat     2400

ctggaactaa gcggccgggc ggccgcttcg agcagacatg ataagataca ttgatgagtt     2460

tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc     2520

tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat     2580

tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagca agtaaaacct     2640

ctacaaatgt ggtaaaatcc gataaggatc gatccgggct ggcgtaatag cgaagaggcc     2700

cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggac gcgccctgta     2760

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     2820

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     2880

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     2940

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     3000

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     3060

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     3120

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     3180

acaaaatatt aacgcttaca atttcctgat gcggtatttt ctccttacgc atctgtgcgg     3240

tatttcacac cgcatacgcg gatctgcgca gcaccatggc ctgaaataac ctctgaaaga     3300

ggaacttggt taggtacctt ctgaggcgga aagaaccagc tgtggaatgt gtgtcagtta     3360

gggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     3420

tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc     3480

atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta     3540

actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca     3600

gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga     3660

ggcctaggct tttgcaaaaa gcttgattct tctgacacaa cagtctcgaa cttaaggcta     3720

gagccaccat gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga     3780

ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc     3840

ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga     3900

atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg     3960

cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc     4020

cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg     4080

atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga     4140

aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc     4200

tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgcgca     4260

tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg     4320

tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct     4380

atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg     4440

accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc     4500

gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg accaagcgac     4560

gcccaacctg ccatcacgat ggccgcaata aaatatcttt attttcatta catctgtgtg     4620

ttggtttttt gtgtgaatcg atagcgataa ggatccgcgt atggtgcact ctcagtacaa     4680

tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc     4740

cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga     4800

gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg     4860

tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg     4920

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     4980

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     5040

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     5100

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     5160

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     5220

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     5280

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     5340

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     5400

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     5460

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     5520

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     5580

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     5640

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     5700

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     5760

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     5820

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     5880

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     5940

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     6000

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     6060

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     6120

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     6180

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     6240

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     6300

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     6360

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     6420

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     6480

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     6540

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     6600

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     6660

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     6720

acatggctcg acagatct                                                   6738


<210>  25
<211>  10455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg      660

cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata      720

agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac      780

agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt      840

gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa      900

ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact      960

cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac     1020

aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact     1080

ataggctagc gccaccatgg cggacctgga ggcggtgctg gccgacgtga gctacctgat     1140

ggccatggag aagagcaagg ccacgccggc cgcgcgcgcc agcaagaaga tactgctgcc     1200

cgagcccagc atccgcagtg tcatgcagaa gtacctggag gaccggggcg aggtgacctt     1260

tgagaagatc ttttcccaga agctggggta cctgctcttc cgagacttct gcctgaacca     1320

cctggaggag gccaggccct tggtggaatt ctatgaggag atcaagaagt acgagaagct     1380

ggagacggag gaggagcgtg tggcccgcag ccgggagatc ttcgactcat acatcatgaa     1440

ggagctgctg gcctgctcgc atcccttctc gaagagtgcc actgagcatg tccaaggcca     1500

cctggggaag aagcaggtgc ctccggatct cttccagcca tacatcgaag agatttgtca     1560

aaacctccga ggggacgtgt tccagaaatt cattgagagc gataagttca cacggttttg     1620

ccagtggaag aatgtggagc tcaacatcca cctgaccatg aatgacttca gcgtgcatcg     1680

catcattggg cgcgggggct ttggcgaggt ctatgggtgc cggaaggctg acacaggcaa     1740

gatgtacgcc atgaagtgcc tggacaaaaa gcgcatcaag atgaagcagg gggagaccct     1800

ggccctgaac gagcgcatca tgctctcgct cgtcagcact ggggactgcc cattcattgt     1860

ctgcatgtca tacgcgttcc acacgccaga caagctcagc ttcatcctgg acctcatgaa     1920

cggtggggac ctgcactacc acctctccca gcacggggtc ttctcagagg ctgacatgcg     1980

cttctatgcg gccgagatca tcctgggcct ggagcacatg cacaaccgct tcgtggtcta     2040

ccgggacctg aagccagcca acatccttct ggacgagcat ggccacgtgc ggatctcgga     2100

cctgggcctg gcctgtgact tctccaagaa gaagccccat gccagcgtgg gcacccacgg     2160

gtacatggct ccggaggtcc tgcagaaggg cgtggcctac gacagcagtg ccgactggtt     2220

ctctctgggg tgcatgctct tcaagttgct gcgggggcac agccccttcc ggcagcacaa     2280

gaccaaagac aagcatgaga tcgaccgcat gacgctgacg atggccgtgg agctgcccga     2340

ctccttctcc cctgaactac gctccctgct ggaggggttg ctgcagaggg atgtcaaccg     2400

gagattgggc tgcctgggcc gaggggctca ggaggtgaaa gagagcccct ttttccgctc     2460

cctggactgg cagatggtct tcttgcagaa gtaccctccc ccgctgatcc ccccacgagg     2520

ggaggtgaac gcggccgacg ccttcgacat tggctccttc gatgaggagg acacaaaagg     2580

aatcaagtta ctggacagtg atcaggagct ctaccgcaac ttccccctca ccatctcgga     2640

gcggtggcag caggaggtgg cagagactgt cttcgacacc atcaacgctg agacagaccg     2700

gctggaggct cgcaagaaag ccaagaacaa gcagctgggc catgaggaag actacgccct     2760

gggcaaggac tgcatcatgc atggctacat gtccaagatg ggcaacccct tcctgaccca     2820

gtggcagcgg cggtacttct acctgttccc caaccgcctc gagtggcggg gcgagggcga     2880

ggccccgcag agcctgctga ccatggagga gatccagtcg gtggaggaga cgcagatcaa     2940

ggagcgcaag tgcctgctcc tcaagatccg cggtgggaaa cagttcattt tgcagtgcga     3000

tagcgaccct gagctggtgc agtggaagaa ggagctgcgc gacgcctacc gcgaggccca     3060

gcagctggtg cagcgggtgc ccaagatgaa gaacaagccg cgctcgcccg tggtggagct     3120

gagcaaggtg ccgctggtcc agcgcggcag tgccaacggc ctcggaaacg ggggaaacgc     3180

acgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc gctttgcctg     3240

gtttccggca ccagaagcgg tgccggaaag ctggctggag tgcgatcttc ctgaggccga     3300

tactgtcgtc gtcccctcaa actggcagat gcacggttac gatgcgccca tctacaccaa     3360

cgtaacctat cccattacgg tcaatccgcc gtttgttccc acggagaatc cgacgggttg     3420

ttactcgctc acatttaatg ttgatgaaag ctggctacag gaaggccaga cgcgaattat     3480

ttttgatggc gttaactcgg cgtttcatct gtggtgcaac gggcgctggg tcggttacgg     3540

ccaggacagt cgtttgccgt ctgaatttga cctgagcgca tttttacgcg ccggagaaaa     3600

ccgcctcgcg gtgatggtgc tgcgttggag tgacggcagt tatctggaag atcaggatat     3660

gtggcggatg agcggcattt tccgtgacgt ctcgttgctg cataaaccga ctacacaaat     3720

cagcgatttc catgttgcca ctcgctttaa tgatgatttc agccgcgctg tactggaggc     3780

tgaagttcag atgtgcggcg agttgcgtga ctacctacgg gtaacagttt ctttatggca     3840

gggtgaaacg caggtcgcca gcggcaccgc gcctttcggc ggtgaaatta tcgatgagcg     3900

tggtggttat gccgatcgcg tcacactacg tctgaacgtc gaaaacccga aactgtggag     3960

cgccgaaatc ccgaatctct atcgtgcggt ggttgaactg cacaccgccg acggcacgct     4020

gattgaagca gaagcctgcg atgtcggttt ccgcgaggtg cggattgaaa atggtctgct     4080

gctgctgaac ggcaagccgt tgctgattcg aggcgttaac cgtcacgagc atcatcctct     4140

gcatggtcag gtcatggatg agcagacgat ggtgcaggat atcctgctga tgaagcagaa     4200

caactttaac gccgtgcgct gttcgcatta tccgaaccat ccgctgtggt acacgctgtg     4260

cgaccgctac ggcctgtatg tggtggatga agccaatatt gaaacccacg gcatggtgcc     4320

aatgaatcgt ctgaccgatg atccgcgctg gctaccggcg atgagcgaac gcgtaacgcg     4380

aatggtgcag cgcgatcgta atcacccgag tgtgatcatc tggtcgctgg ggaatgaatc     4440

aggccacggc gctaatcacg acgcgctgta tcgctggatc aaatctgtcg atccttcccg     4500

cccggtgcag tatgaaggcg gcggagccga caccacggcc accgatatta tttgcccgat     4560

gtacgcgcgc gtggatgaag accagccctt cccggctgtg ccgaaatggt ccatcaaaaa     4620

atggctttcg ctacctggag agacgcgccc gctgatcctt tgcgaatacg cccacgcgat     4680

gggtaacagt cttggcggtt tcgctaaata ctggcaggcg tttcgtcagt atccccgttt     4740

acagggcggc ttcgtctggg actgggtgga tcagtcgctg attaaatatg atgaaaacgg     4800

caacccgtgg tcggcttacg gcggtgattt tggcgatacg ccgaacgatc gccagttctg     4860

tatgaacggt ctggtctttg ccgaccgcac gccgcatcca gcgctgacgg aagcaaaaca     4920

ccagcagcag tttttccagt tccgtttatc cgggcaaacc atcgaagtga ccagcgaata     4980

cctgttccgt catagcgata acgagctcct gcactggatg gtggcgctgg atggtaagcc     5040

gctggcaagc ggtgaagtgc ctctggatgt cgctccacaa ggtaaacagt tgattgaact     5100

gcctgaacta ccgcagccgg agagcgccgg gcaactctgg ctcacagtac gcgtagtgca     5160

accgaacgcg accgcatggt cagaagccgg gcacatcagc gcctggcagc agtggcgtct     5220

ggcggaaaac ctcagtgtga cgctccccgc cgcgtcccac gccatcccgc atctgaccac     5280

cagcgaaatg gatttttgca tcgagctggg taataagcgt tggcaattta accgccagtc     5340

aggctttctt tcacagatgt ggattggcga taaaaaacaa ctgctgacgc cgctgcgcga     5400

tcagttcacc cgtgcaccgc tggataacga cattggcgta agtgaagcga cccgcattga     5460

ccctaacgcc tgggtcgaac gctggaaggc ggcgggccat taccaggccg aagcagcgtt     5520

gttgcagtgc acggcagata cacttgctga tgcggtgctg attacgaccg ctcacgcgtg     5580

gcagcatcag gggaaaacct tatttatcag ccggaaaacc taccggattg atggtagtgg     5640

tcaaatggcg attaccgttg atgttgaagt ggcgagcgat acaccgcatc cggcgcggat     5700

tggcctgaac tgccagctgg cgcaggtagc agagcgggta aactggctcg gattagggcc     5760

gcaagaaaac tatcccgacc gccttactgc cgcctgtttt gaccgctggg atctgccatt     5820

gtcagacatg tataccccgt acgtcttccc gagcgaaaac ggtctgcgct gcgggacgcg     5880

cgaattgaat tatggcccac accagtggcg cggcgacttc cagttcaaca tcagccgcta     5940

cagtcaacag caactgatgg aaaccagcca tcgccatctg ctgcacgcgg aagaaggcac     6000

atggctgaat atcgacggtt tccatatggg gattggtggc gacgactcct ggagcccgtc     6060

agtatcggcg gaattccagc tgagcgccgg tcgctaccat taccagttgg tctggtgtca     6120

aaaataagcg gccgggcggc cgcttcgagc agacatgata agatacattg atgagtttgg     6180

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     6240

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     6300

ttttatgttt caggttcagg gggagatgtg ggaggttttt taaagcaagt aaaacctcta     6360

caaatgtggt aaaatccgat aaggatcgat ccgggctggc gtaatagcga agaggcccgc     6420

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggacgcg ccctgtagcg     6480

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     6540

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     6600

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     6660

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     6720

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     6780

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     6840

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca     6900

aaatattaac gcttacaatt tcctgatgcg gtattttctc cttacgcatc tgtgcggtat     6960

ttcacaccgc atacgcggat ctgcgcagca ccatggcctg aaataacctc tgaaagagga     7020

acttggttag gtaccttctg aggcggaaag aaccagctgt ggaatgtgtg tcagttaggg     7080

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     7140

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     7200

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     7260

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     7320

gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     7380

ctaggctttt gcaaaaagct tgattcttct gacacaacag tctcgaactt aaggctagag     7440

ccaccatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc     7500

tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc     7560

tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg     7620

aactgcagga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag     7680

ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg     7740

ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg     7800

caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac     7860

atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg     7920

acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc     7980

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg     8040

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc     8100

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc     8160

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc     8220

ttcttgacga gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc     8280

caacctgcca tcacgatggc cgcaataaaa tatctttatt ttcattacat ctgtgtgttg     8340

gttttttgtg tgaatcgata gcgataagga tccgcgtatg gtgcactctc agtacaatct     8400

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     8460

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     8520

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     8580

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     8640

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     8700

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     8760

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     8820

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     8880

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     8940

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     9000

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     9060

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     9120

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     9180

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     9240

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     9300

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     9360

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     9420

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     9480

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     9540

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     9600

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     9660

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     9720

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     9780

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     9840

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     9900

aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt     9960

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt    10020

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat    10080

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct    10140

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca    10200

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag    10260

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc    10320

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga    10380

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca    10440

tggctcgaca gatct                                                     10455


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Gly Asn Gly Gly Asn Ala 
1               5       


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
ggaaacgggg gaaacgca                                                     18


<210>  28
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu 
1               5                   10                  15      


Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe 
            20                  25                  30          


Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln 
        35                  40                  45              


Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala 
    50                  55                  60                  


Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Asp Thr Val Val Val Pro Ser Asn Trp Gln Met 
                85                  90      


<210>  29
<211>  981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Arg Thr Asp Arg Pro Ser Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp 
1               5                   10                  15      


Arg Phe Ala Trp Phe Pro Ala Pro Glu Ala Val Pro Glu Ser Trp Leu 
            20                  25                  30          


Glu Cys Asp Leu Pro Glu Ala Asp Thr Val Val Val Pro Ser Asn Trp 
        35                  40                  45              


Gln Met His Gly Tyr Asp Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro 
    50                  55                  60                  


Ile Thr Val Asn Pro Pro Phe Val Pro Thr Glu Asn Pro Thr Gly Cys 
65                  70                  75                  80  


Tyr Ser Leu Thr Phe Asn Val Asp Glu Ser Trp Leu Gln Glu Gly Gln 
                85                  90                  95      


Thr Arg Ile Ile Phe Asp Gly Val Asn Ser Ala Phe His Leu Trp Cys 
            100                 105                 110         


Asn Gly Arg Trp Val Gly Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu 
        115                 120                 125             


Phe Asp Leu Ser Ala Phe Leu Arg Ala Gly Glu Asn Arg Leu Ala Val 
    130                 135                 140                 


Met Val Leu Arg Trp Ser Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met 
145                 150                 155                 160 


Trp Arg Met Ser Gly Ile Phe Arg Asp Val Ser Leu Leu His Lys Pro 
                165                 170                 175     


Thr Thr Gln Ile Ser Asp Phe His Val Ala Thr Arg Phe Asn Asp Asp 
            180                 185                 190         


Phe Ser Arg Ala Val Leu Glu Ala Glu Val Gln Met Cys Gly Glu Leu 
        195                 200                 205             


Arg Asp Tyr Leu Arg Val Thr Val Ser Leu Trp Gln Gly Glu Thr Gln 
    210                 215                 220                 


Val Ala Ser Gly Thr Ala Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg 
225                 230                 235                 240 


Gly Gly Tyr Ala Asp Arg Val Thr Leu Arg Leu Asn Val Glu Asn Pro 
                245                 250                 255     


Lys Leu Trp Ser Ala Glu Ile Pro Asn Leu Tyr Arg Ala Val Val Glu 
            260                 265                 270         


Leu His Thr Ala Asp Gly Thr Leu Ile Glu Ala Glu Ala Cys Asp Val 
        275                 280                 285             


Gly Phe Arg Glu Val Arg Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly 
    290                 295                 300                 


Lys Pro Leu Leu Ile Arg Gly Val Asn Arg His Glu His His Pro Leu 
305                 310                 315                 320 


His Gly Gln Val Met Asp Glu Gln Thr Met Val Gln Asp Ile Leu Leu 
                325                 330                 335     


Met Lys Gln Asn Asn Phe Asn Ala Val Arg Cys Ser His Tyr Pro Asn 
            340                 345                 350         


His Pro Leu Trp Tyr Thr Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val 
        355                 360                 365             


Asp Glu Ala Asn Ile Glu Thr His Gly Met Val Pro Met Asn Arg Leu 
    370                 375                 380                 


Thr Asp Asp Pro Arg Trp Leu Pro Ala Met Ser Glu Arg Val Thr Arg 
385                 390                 395                 400 


Met Val Gln Arg Asp Arg Asn His Pro Ser Val Ile Ile Trp Ser Leu 
                405                 410                 415     


Gly Asn Glu Ser Gly His Gly Ala Asn His Asp Ala Leu Tyr Arg Trp 
            420                 425                 430         


Ile Lys Ser Val Asp Pro Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly 
        435                 440                 445             


Ala Asp Thr Thr Ala Thr Asp Ile Ile Cys Pro Met Tyr Ala Arg Val 
    450                 455                 460                 


Asp Glu Asp Gln Pro Phe Pro Ala Val Pro Lys Trp Ser Ile Lys Lys 
465                 470                 475                 480 


Trp Leu Ser Leu Pro Gly Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr 
                485                 490                 495     


Ala His Ala Met Gly Asn Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln 
            500                 505                 510         


Ala Phe Arg Gln Tyr Pro Arg Leu Gln Gly Gly Phe Val Trp Asp Trp 
        515                 520                 525             


Val Asp Gln Ser Leu Ile Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser 
    530                 535                 540                 


Ala Tyr Gly Gly Asp Phe Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys 
545                 550                 555                 560 


Met Asn Gly Leu Val Phe Ala Asp Arg Thr Pro His Pro Ala Leu Thr 
                565                 570                 575     


Glu Ala Lys His Gln Gln Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln 
            580                 585                 590         


Thr Ile Glu Val Thr Ser Glu Tyr Leu Phe Arg His Ser Asp Asn Glu 
        595                 600                 605             


Leu Leu His Trp Met Val Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly 
    610                 615                 620                 


Glu Val Pro Leu Asp Val Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu 
625                 630                 635                 640 


Pro Glu Leu Pro Gln Pro Glu Ser Ala Gly Gln Leu Trp Leu Thr Val 
                645                 650                 655     


Arg Val Val Gln Pro Asn Ala Thr Ala Trp Ser Glu Ala Gly His Ile 
            660                 665                 670         


Ser Ala Trp Gln Gln Trp Arg Leu Ala Glu Asn Leu Ser Val Thr Leu 
        675                 680                 685             


Pro Ala Ala Ser His Ala Ile Pro His Leu Thr Thr Ser Glu Met Asp 
    690                 695                 700                 


Phe Cys Ile Glu Leu Gly Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser 
705                 710                 715                 720 


Gly Phe Leu Ser Gln Met Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr 
                725                 730                 735     


Pro Leu Arg Asp Gln Phe Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly 
            740                 745                 750         


Val Ser Glu Ala Thr Arg Ile Asp Pro Asn Ala Trp Val Glu Arg Trp 
        755                 760                 765             


Lys Ala Ala Gly His Tyr Gln Ala Glu Ala Ala Leu Leu Gln Cys Thr 
    770                 775                 780                 


Ala Asp Thr Leu Ala Asp Ala Val Leu Ile Thr Thr Ala His Ala Trp 
785                 790                 795                 800 


Gln His Gln Gly Lys Thr Leu Phe Ile Ser Arg Lys Thr Tyr Arg Ile 
                805                 810                 815     


Asp Gly Ser Gly Gln Met Ala Ile Thr Val Asp Val Glu Val Ala Ser 
            820                 825                 830         


Asp Thr Pro His Pro Ala Arg Ile Gly Leu Asn Cys Gln Leu Ala Gln 
        835                 840                 845             


Val Ala Glu Arg Val Asn Trp Leu Gly Leu Gly Pro Gln Glu Asn Tyr 
    850                 855                 860                 


Pro Asp Arg Leu Thr Ala Ala Cys Phe Asp Arg Trp Asp Leu Pro Leu 
865                 870                 875                 880 


Ser Asp Met Tyr Thr Pro Tyr Val Phe Pro Ser Glu Asn Gly Leu Arg 
                885                 890                 895     


Cys Gly Thr Arg Glu Leu Asn Tyr Gly Pro His Gln Trp Arg Gly Asp 
            900                 905                 910         


Phe Gln Phe Asn Ile Ser Arg Tyr Ser Gln Gln Gln Leu Met Glu Thr 
        915                 920                 925             


Ser His Arg His Leu Leu His Ala Glu Glu Gly Thr Trp Leu Asn Ile 
    930                 935                 940                 


Asp Gly Phe His Met Gly Ile Gly Gly Asp Asp Ser Trp Ser Pro Ser 
945                 950                 955                 960 


Val Ser Ala Glu Phe Gln Leu Ser Ala Gly Arg Tyr His Tyr Gln Leu 
                965                 970                 975     


Val Trp Cys Gln Lys 
            980     


<210>  30
<211>  273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
atgattacgg attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt       60

acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag      120

gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgctttgcc      180

tggtttccgg caccagaagc ggtgccggaa agctggctgg agtgcgatct tcctgaggcc      240

gatactgtcg tcgtcccctc aaactggcag atg                                   273


<210>  31
<211>  2946
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggcg ctttgcctgg       60

tttccggcac cagaagcggt gccggaaagc tggctggagt gcgatcttcc tgaggccgat      120

actgtcgtcg tcccctcaaa ctggcagatg cacggttacg atgcgcccat ctacaccaac      180

gtaacctatc ccattacggt caatccgccg tttgttccca cggagaatcc gacgggttgt      240

tactcgctca catttaatgt tgatgaaagc tggctacagg aaggccagac gcgaattatt      300

tttgatggcg ttaactcggc gtttcatctg tggtgcaacg ggcgctgggt cggttacggc      360

caggacagtc gtttgccgtc tgaatttgac ctgagcgcat ttttacgcgc cggagaaaac      420

cgcctcgcgg tgatggtgct gcgttggagt gacggcagtt atctggaaga tcaggatatg      480

tggcggatga gcggcatttt ccgtgacgtc tcgttgctgc ataaaccgac tacacaaatc      540

agcgatttcc atgttgccac tcgctttaat gatgatttca gccgcgctgt actggaggct      600

gaagttcaga tgtgcggcga gttgcgtgac tacctacggg taacagtttc tttatggcag      660

ggtgaaacgc aggtcgccag cggcaccgcg cctttcggcg gtgaaattat cgatgagcgt      720

ggtggttatg ccgatcgcgt cacactacgt ctgaacgtcg aaaacccgaa actgtggagc      780

gccgaaatcc cgaatctcta tcgtgcggtg gttgaactgc acaccgccga cggcacgctg      840

attgaagcag aagcctgcga tgtcggtttc cgcgaggtgc ggattgaaaa tggtctgctg      900

ctgctgaacg gcaagccgtt gctgattcga ggcgttaacc gtcacgagca tcatcctctg      960

catggtcagg tcatggatga gcagacgatg gtgcaggata tcctgctgat gaagcagaac     1020

aactttaacg ccgtgcgctg ttcgcattat ccgaaccatc cgctgtggta cacgctgtgc     1080

gaccgctacg gcctgtatgt ggtggatgaa gccaatattg aaacccacgg catggtgcca     1140

atgaatcgtc tgaccgatga tccgcgctgg ctaccggcga tgagcgaacg cgtaacgcga     1200

atggtgcagc gcgatcgtaa tcacccgagt gtgatcatct ggtcgctggg gaatgaatca     1260

ggccacggcg ctaatcacga cgcgctgtat cgctggatca aatctgtcga tccttcccgc     1320

ccggtgcagt atgaaggcgg cggagccgac accacggcca ccgatattat ttgcccgatg     1380

tacgcgcgcg tggatgaaga ccagcccttc ccggctgtgc cgaaatggtc catcaaaaaa     1440

tggctttcgc tacctggaga gacgcgcccg ctgatccttt gcgaatacgc ccacgcgatg     1500

ggtaacagtc ttggcggttt cgctaaatac tggcaggcgt ttcgtcagta tccccgttta     1560

cagggcggct tcgtctggga ctgggtggat cagtcgctga ttaaatatga tgaaaacggc     1620

aacccgtggt cggcttacgg cggtgatttt ggcgatacgc cgaacgatcg ccagttctgt     1680

atgaacggtc tggtctttgc cgaccgcacg ccgcatccag cgctgacgga agcaaaacac     1740

cagcagcagt ttttccagtt ccgtttatcc gggcaaacca tcgaagtgac cagcgaatac     1800

ctgttccgtc atagcgataa cgagctcctg cactggatgg tggcgctgga tggtaagccg     1860

ctggcaagcg gtgaagtgcc tctggatgtc gctccacaag gtaaacagtt gattgaactg     1920

cctgaactac cgcagccgga gagcgccggg caactctggc tcacagtacg cgtagtgcaa     1980

ccgaacgcga ccgcatggtc agaagccggg cacatcagcg cctggcagca gtggcgtctg     2040

gcggaaaacc tcagtgtgac gctccccgcc gcgtcccacg ccatcccgca tctgaccacc     2100

agcgaaatgg atttttgcat cgagctgggt aataagcgtt ggcaatttaa ccgccagtca     2160

ggctttcttt cacagatgtg gattggcgat aaaaaacaac tgctgacgcc gctgcgcgat     2220

cagttcaccc gtgcaccgct ggataacgac attggcgtaa gtgaagcgac ccgcattgac     2280

cctaacgcct gggtcgaacg ctggaaggcg gcgggccatt accaggccga agcagcgttg     2340

ttgcagtgca cggcagatac acttgctgat gcggtgctga ttacgaccgc tcacgcgtgg     2400

cagcatcagg ggaaaacctt atttatcagc cggaaaacct accggattga tggtagtggt     2460

caaatggcga ttaccgttga tgttgaagtg gcgagcgata caccgcatcc ggcgcggatt     2520

ggcctgaact gccagctggc gcaggtagca gagcgggtaa actggctcgg attagggccg     2580

caagaaaact atcccgaccg ccttactgcc gcctgttttg accgctggga tctgccattg     2640

tcagacatgt ataccccgta cgtcttcccg agcgaaaacg gtctgcgctg cgggacgcgc     2700

gaattgaatt atggcccaca ccagtggcgc ggcgacttcc agttcaacat cagccgctac     2760

agtcaacagc aactgatgga aaccagccat cgccatctgc tgcacgcgga agaaggcaca     2820

tggctgaata tcgacggttt ccatatgggg attggtggcg acgactcctg gagcccgtca     2880

gtatcggcgg aattccagct gagcgccggt cgctaccatt accagttggt ctggtgtcaa     2940

aaataa                                                                2946


<210>  32
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Cys Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu Asn Pro Gly 
1               5                   10                  15      


Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe Ala Ser Trp 
            20                  25                  30          


Arg Asn Ser Glu Glu Ala Arg Thr Asp Cys Pro Ser Gln Gln Leu 
        35                  40                  45          


