                         SEQUENCE LISTING

<110>  Jensen, Michael
 
<120>  Chimeric Immunoreceptor Useful In Treating Human Cancers

<130>  1954-517

<150>  60/286,981
<151>  2001-04-30

<150>  61/091,915
<151>  2008-08-26

<150>  10/134,645
<151>  2002-04-30

<150>  11/274,344
<151>  2005-11-16

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  102
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  EcoRI restriction site

<400>  1
tatgaattca tggcgctttt gttgaccacg gtcattgctc tcacttgcct tggcggcttt       60

gcctccccag gccctgtgcc tccctctaca gccctcaggt ac                         102


<210>  2
<211>  101
<212>  DNA
<213>  Homo sapiens

<400>  2
gttgatgctc cataccatgc tgccattgca gagcggagcc ttctggttct gggtgatgtt       60

gaccagctcc tcaatgaggt acctgagggc tgtagaggga g                          101


<210>  3
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  3
ctctgggtct tctcgatggc actgcagcct gacacgttga tcagggattc cagggctgca       60

cagtacatgc cagctgtcag gttgatgctc cataccatgc                            100


<210>  4
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  4
cctcgatttt ggtgtctcgg acatgcaagc tggaaaactg cccagctgag accttgtgcg       60

ggcagaatcc gctcagcatc ctctgggtct tctcgatggc                            100


<210>  5
<211>  96
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(8)
<223>  BamHI restriction site

<400>  5
tcggatcctc agttgaaccg tccctcgcga aaaagtttct ttaaatgtaa gagcaggtcc       60

tttacaaact gggccacctc gattttggtg tctcgg                                 96


<210>  6
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  6
caacctgaca gctggcatgt actgtgcagc cctggaatc                              39


<210>  7
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  7
gattccaggg ctgcacagta catgccagct gtcaggttg                              39


<210>  8
<211>  43
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  XbaI restriction site

<400>  8
atctctagag ccgccaccat gcttctcctg gtgacaagcc ttc                         43


<210>  9
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  9
gagggaggca cagggcctgg gatcaggagg aatg                                   34


<210>  10
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  10
cattcctcct gatcccaggc cctgtgcctc cctc                                   34


<210>  11
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  11
gggaccatat ttggactcgt tgaaccgtcc ctcgc                                  35


<210>  12
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  12
gcgagggacg gttcaacgag tccaaatatg gtccc                                  35


<210>  13
<211>  26
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(10)
<223>  NotI restriction site

<400>  13
atgcggccgc tcagcgaggg ggcagg                                            26


<210>  14
<211>  6783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid DNA vector incorporating human, simian virus 40, E. coli,
       cytomegalovirus and bovine sequences

<400>  14
tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt       60

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg      120

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga      180

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag      240

aacacagctg aagcttcgag gggctcgcat ctctccttca cgcgcccgcc gccctacctg      300

aggccgccat ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg      360

aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg agaccgggcc tttgtccggc      420

gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga ccctgcttgc      480

tcaactctac gtctttgttt cgttttctgt tctgcgccgt tacagatcca agctgtgacc      540

ggcgcctacg taagtgatat ctactagatt tatcaaaaag agtgttgact tgtgagcgct      600

cacaattgat acggattcat cgagagggac acgtcgacta ctaaccttct tctctttcct      660

acagctgaga tcaccctaga gccgccacca tgcttctcct ggtgacaagc cttctgctct      720

gtgagttacc acacccagca ttcctcctga tcccaggccc tgtgcctccc tctacagccc      780

tcaggtacct cattgaggag ctggtcaaca tcacccagaa ccagaaggct ccgctctgca      840

atggcagcat ggtatggagc atcaacctga cagctggcat gtactgtgca gccctggaat      900

ccctgatcaa cgtgtcaggc tgcagtgcca tcgagaagac ccagaggatg ctgagcggat      960

tctgcccgca caaggtctca gctgggcagt tttccagctt gcatgtccga gacaccaaaa     1020

tcgaggtggc ccagtttgta aaggacctgc tcttacattt aaagaaactt tttcgcgagg     1080

gacggttcaa cgagtccaaa tatggtcccc catgcccacc atgcccagca cctgagttcc     1140

tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc atgatctccc     1200

ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc gaggtccagt     1260

tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc     1320

agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga     1380

acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa     1440

ccatctccaa agccaaaggg cagccccgag agccacaggt gtacaccctg cccccatccc     1500

aggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca     1560

gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc     1620

ctcccgtgct ggactccgac ggctccttct tcctctacag caggctaacc gtggacaaga     1680

gcaggtggca ggaggggaat gtcttctcat gctccgtgat gcatgaggct ctgcacaacc     1740

actacacaca gaagagcctc tccctgtccc taggtaaaat ggccctgatt gtgctggggg     1800

gcgtcgccgg cctcctgctt ttcattgggc taggcatctt cttcagagtg aagttcagca     1860

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     1920

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     1980

ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata     2040

agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc     2100

acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca     2160

tgcaggccct gccccctcgc tgagcggccg gcgaaggagg cctagatcta tcgattgtac     2220

agctagctcg acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag     2280

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt gaaatttgtg     2340

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     2400

gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa     2460

acctctacaa atgtggtaga tccatttaaa tgttagcgaa gaacatgtga gcaaaaggcc     2520

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     2580

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     2640

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     2700

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat     2760

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     2820

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     2880

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     2940

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     3000

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     3060

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     3120

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     3180

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatggct agttaattaa     3240

gctgcaataa acaatcatta ttttcattgg atctgtgtgt tggttttttg tgtgggcttg     3300

ggggaggggg aggccagaat gactccaaga gctacaggaa ggcaggtcag agaccccact     3360

ggacaaacag tggctggact ctgcaccata acacacaatc aacaggggag tgagctggat     3420

cgagctagag tccgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga     3480

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt     3540

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt     3600

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca     3660

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt     3720

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt     3780

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     3840

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     3900

cggtaggcgt gtacggtggg aggtctatat aagcagagct cgtttagtga accgtcagat     3960

cgcctggaga cgccatccac gctgttttga cctccataga agacaccggg accgatccag     4020

cctccgcggc cgggaacggt gcattggaac gcggattccc cgtgccaaga gtgacgtaag     4080

taccgcctat agagtctata ggcccaccta gttgtgaccg gcgcctagtg ttgacaatta     4140

atcatcggca tagtatatcg gcatagtata atacgactca ctataggagg gccaccatgt     4200

cgactactaa ccttcttctc tttcctacag ctgagatcac cggtaggagg gccatcatga     4260

aaaagcctga actcaccgcg acgtctgtcg cgaagtttct gatcgaaaag ttcgacagcg     4320

tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc ttcgatgtag     4380

gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac aaagatcgtt     4440

atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg     4500

aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag     4560

acctgcctga aaccgaactg cccgctgttc tgcaacccgt cgcggagctc atggatgcga     4620

tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg caaggaatcg     4680

gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat gtgtatcact     4740

ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga     4800

tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca     4860

acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc gaggcgatgt     4920

tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta     4980

tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc     5040

tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca     5100

atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg     5160

ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc gatggctgtg     5220

tagaagtcgc gtctgcgttc gaccaggctg cgcgttctcg cggccatagc aaccgacgta     5280

cggcgttgcg ccctcgccgg cagcaagaag ccacggaagt ccgcccggag cagaaaatgc     5340

ccacgctact gcgggtttat atagacggtc cccacgggat ggggaaaacc accaccacgc     5400

aactgctggt ggccctgggt tcgcgcgacg atatcgtcta cgtacccgag ccgatgactt     5460

actggcgggt gctgggggct tccgagacaa tcgcgaacat ctacaccaca caacaccgcc     5520

tcgaccaggg tgagatatcg gccggggacg cggcggtggt aatgacaagc gcccagataa     5580

caatgggcat gccttatgcc gtgaccgacg ccgttctggc tcctcatatc gggggggagg     5640

ctgggagctc acatgccccg cccccggccc tcaccctcat cttcgaccgc catcccatcg     5700

ccgccctcct gtgctacccg gccgcgcggt accttatggg cagcatgacc ccccaggccg     5760

tgctggcgtt cgtggccctc atcccgccga ccttgcccgg caccaacatc gtgcttgggg     5820

cccttccgga ggacagacac atcgaccgcc tggccaaacg ccagcgcccc ggcgagcggc     5880

tggacctggc tatgctggct gcgattcgcc gcgtttacgg gctacttgcc aatacggtgc     5940

ggtatctgca gtgcggcggg tcgtggcggg aggactgggg acagctttcg gggacggccg     6000

tgccgcccca gggtgccgag ccccagagca acgcgggccc acgaccccat atcggggaca     6060

cgttatttac cctgtttcgg gcccccgagt tgctggcccc caacggcgac ctgtataacg     6120

tgtttgcctg ggccttggac gtcttggcca aacgcctccg ttccatgcac gtctttatcc     6180

tggattacga ccaatcgccc gccggctgcc gggacgccct gctgcaactt acctccggga     6240

tggtccagac ccacgtcacc acccccggct ccataccgac gatatgcgac ctggcgcgca     6300

cgtttgcccg ggagatgggg gaggctaact gagtcgagaa ttcgctagag ggccctattc     6360

tatagtgtca cctaaatgct agagctcgct gatcagcctc gactgtgcct tctagttgcc     6420

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     6480

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     6540

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     6600

atgcgcaggg cccaattgct cgagcggccg caataaaata tctttatttt cattacatct     6660

gtgtgttggt tttttgtgtg aatcgtaact aacatacgct ctccatcaaa acaaaacgaa     6720

acaaaacaaa ctagcaaaat aggctgtccc cagtgcaagt gcaggtgcca gaacatttct     6780

cta                                                                   6783


<210>  15
<211>  1491
<212>  DNA
<213>  Homo sapiens

<400>  15
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccaggcc ctgtgcctcc ctctacagcc ctcaggtacc tcattgagga gctggtcaac      120

atcacccaga accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg      180

acagctggca tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc      240

atcgagaaga cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag      300

ttttccagct tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg      360

ctcttacatt taaagaaact ttttcgcgag ggacggttca acgagtccaa atatggtccc      420

ccatgcccac catgcccagc acctgagttc ctggggggac catcagtctt cctgttcccc      480

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      540

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg      600

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc      660

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc      720

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga      780

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc      840

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat      900

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc      960

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca     1020

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtcc     1080

ctaggtaaaa tggccctgat tgtgctgggg ggcgtcgccg gcctcctgct tttcattggg     1140

ctaggcatct tcttcagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1200

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1260

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1320

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1380

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1440

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              1491


<210>  16
<211>  6783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid DNA vector incorporating human, simian virus 40, E. coli,
       cytomegalovirus and bovine sequences

<400>  16
tagagaaatg ttctggcacc tgcacttgca ctggggacag cctattttgc tagtttgttt       60

tgtttcgttt tgttttgatg gagagcgtat gttagttacg attcacacaa aaaaccaaca      120

cacagatgta atgaaaataa agatatttta ttgcggccgc tcgagcaatt gggccctgcg      180

catgcctgct attgtcttcc caatcctccc ccttgctgtc ctgccccacc ccacccccca      240

gaatagaatg acacctactc agacaatgcg atgcaatttc ctcattttat taggaaagga      300

cagtgggagt ggcaccttcc agggtcaagg aaggcacggg ggaggggcaa acaacagatg      360

gctggcaact agaaggcaca gtcgaggctg atcagcgagc tctagcattt aggtgacact      420

atagaatagg gccctctagc gaattctcga ctcagttagc ctcccccatc tcccgggcaa      480

acgtgcgcgc caggtcgcat atcgtcggta tggagccggg ggtggtgacg tgggtctgga      540

ccatcccgga ggtaagttgc agcagggcgt cccggcagcc ggcgggcgat tggtcgtaat      600

ccaggataaa gacgtgcatg gaacggaggc gtttggccaa gacgtccaag gcccaggcaa      660

acacgttata caggtcgccg ttgggggcca gcaactcggg ggcccgaaac agggtaaata      720

acgtgtcccc gatatggggt cgtgggcccg cgttgctctg gggctcggca ccctggggcg      780

gcacggccgt ccccgaaagc tgtccccagt cctcccgcca cgacccgccg cactgcagat      840

accgcaccgt attggcaagt agcccgtaaa cgcggcgaat cgcagccagc atagccaggt      900

ccagccgctc gccggggcgc tggcgtttgg ccaggcggtc gatgtgtctg tcctccggaa      960

gggccccaag cacgatgttg gtgccgggca aggtcggcgg gatgagggcc acgaacgcca     1020

gcacggcctg gggggtcatg ctgcccataa ggtaccgcgc ggccgggtag cacaggaggg     1080

cggcgatggg atggcggtcg aagatgaggg tgagggccgg gggcggggca tgtgagctcc     1140

cagcctcccc cccgatatga ggagccagaa cggcgtcggt cacggcataa ggcatgccca     1200

ttgttatctg ggcgcttgtc attaccaccg ccgcgtcccc ggccgatatc tcaccctggt     1260

cgaggcggtg ttgtgtggtg tagatgttcg cgattgtctc ggaagccccc agcacccgcc     1320

agtaagtcat cggctcgggt acgtagacga tatcgtcgcg cgaacccagg gccaccagca     1380

gttgcgtggt ggtggttttc cccatcccgt ggggaccgtc tatataaacc cgcagtagcg     1440

tgggcatttt ctgctccggg cggacttccg tggcttcttg ctgccggcga gggcgcaacg     1500

ccgtacgtcg gttgctatgg ccgcgagaac gcgcagcctg gtcgaacgca gacgcgactt     1560

ctacacagcc atcggtccag acggccgcgc ttctgcgggc gatttgtgta cgcccgacag     1620

tcccggctcc ggatcggacg attgcgtcgc atcgaccctg cgcccaagct gcatcatcga     1680

aattgccgtc aaccaagctc tgatagagtt ggtcaagacc aatgcggagc atatacgccc     1740

ggagccgcgg cgatcctgca agctccggat gcctccgctc gaagtagcgc gtctgctgct     1800

ccatacaagc caaccacggc ctccagaaga agatgttggc gacctcgtat tgggaatccc     1860

cgaacatcgc ctcgctccag tcaatgaccg ctgttatgcg gccattgtcc gtcaggacat     1920

tgttggagcc gaaatccgcg tgcacgaggt gccggacttc ggggcagtcc tcggcccaaa     1980

gcatcagctc atcgagagcc tgcgcgacgg acgcactgac ggtgtcgtcc atcacagttt     2040

gccagtgata cacatgggga tcagcaatcg cgcatatgaa atcacgccat gtagtgtatt     2100

gaccgattcc ttgcggtccg aatgggccga acccgctcgt ctggctaaga tcggccgcag     2160

cgatcgcatc catgagctcc gcgacgggtt gcagaacagc gggcagttcg gtttcaggca     2220

ggtcttgcaa cgtgacaccc tgtgcacggc gggagatgca ataggtcagg ctctcgctga     2280

attccccaat gtcaagcact tccggaatcg ggagcgcggc cgatgcaaag tgccgataaa     2340

cataacgatc tttgtagaaa ccatcggcgc agctatttac ccgcaggaca tatccacgcc     2400

ctcctacatc gaagctgaaa gcacgagatt cttcgccctc cgagagctgc atcaggtcgg     2460

agacgctgtc gaacttttcg atcagaaact tcgcgacaga cgtcgcggtg agttcaggct     2520

ttttcatgat ggccctccta ccggtgatct cagctgtagg aaagagaaga aggttagtag     2580

tcgacatggt ggccctccta tagtgagtcg tattatacta tgccgatata ctatgccgat     2640

gattaattgt caacactagg cgccggtcac aactaggtgg gcctatagac tctataggcg     2700

gtacttacgt cactcttggc acggggaatc cgcgttccaa tgcaccgttc ccggccgcgg     2760

aggctggatc ggtcccggtg tcttctatgg aggtcaaaac agcgtggatg gcgtctccag     2820

gcgatctgac ggttcactaa acgagctctg cttatataga cctcccaccg tacacgccta     2880

ccgcccattt gcgtcaatgg ggcggagttg ttacgacatt ttggaaagtc ccgttgattt     2940

tggtgccaaa acaaactccc attgacgtca atggggtgga gacttggaaa tccccgtgag     3000

tcaaaccgct atccacgccc attgatgtac tgccaaaacc gcatcaccat ggtaatagcg     3060

atgactaata cgtagatgta ctgccaagta ggaaagtccc ataaggtcat gtactgggca     3120

taatgccagg cgggccattt accgtcattg acgtcaatag ggggcgtact tggcatatga     3180

tacacttgat gtactgccaa gtgggcagtt taccgtaaat actccaccca ttgacgtcaa     3240

tggaaagtcc ctattggcgt tactatggga acatacgtca ttattgacgt caatgggcgg     3300

gggtcgttgg gcggtcagcc aggcgggcca tttaccgtaa gttatgtaac ggactctagc     3360

tcgatccagc tcactcccct gttgattgtg tgttatggtg cagagtccag ccactgtttg     3420

tccagtgggg tctctgacct gccttcctgt agctcttgga gtcattctgg cctccccctc     3480

ccccaagccc acacaaaaaa ccaacacaca gatccaatga aaataatgat tgtttattgc     3540

agcttaatta actagccatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     3600

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     3660

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     3720

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     3780

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     3840

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     3900

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     3960

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     4020

agcattgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     4080

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     4140

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     4200

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     4260

gctggccttt tgctcacatg ttcttcgcta acatttaaat ggatctacca catttgtaga     4320

ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa     4380

tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag     4440

catcacaaat ttcacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt     4500

tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtcgagcta     4560

gctgtacaat cgatagatct aggcctcctt cgccggccgc tcagcgaggg ggcagggcct     4620

gcatgtgaag ggcgtcgtag gtgtccttgg tggctgtact gagaccctgg taaaggccat     4680

cgtgcccctt gcccctccgg cgctcgcctt tcatcccaat ctcactgtag gcctccgcca     4740

tcttatcttt ctgcagttca ttgtacaggc cttcctgagg gttcttcctt ctcggctttc     4800

cccccatctc agggtcccgg ccacgtctct tgtccaaaac atcgtactcc tctcttcgtc     4860

ctagattgag ctcgttatag agctggttct ggccctgctg gtacgcgggg gcgtctgcgc     4920

tcctgctgaa cttcactctg aagaagatgc ctagcccaat gaaaagcagg aggccggcga     4980

cgccccccag cacaatcagg gccattttac ctagggacag ggagaggctc ttctgtgtgt     5040

agtggttgtg cagagcctca tgcatcacgg agcatgagaa gacattcccc tcctgccacc     5100

tgctcttgtc cacggttagc ctgctgtaga ggaagaagga gccgtcggag tccagcacgg     5160

gaggcgtggt cttgtagttg ttctccggct gcccattgct ctcccactcc acggcgatgt     5220

cgctggggta gaagcctttg accaggcagg tcaggctgac ctggttcttg gtcatctcct     5280

cctgggatgg gggcagggtg tacacctgtg gctctcgggg ctgccctttg gctttggaga     5340

tggttttctc gatggaggac gggaggcctt tgttggagac cttgcacttg tactccttgc     5400

cgttcagcca gtcctggtgc aggacggtga ggacgctgac cacacggtac gtgctgttga     5460

actgctcctc ccgcggcttt gtcttggcat tatgcacctc cacgccatcc acgtaccagt     5520

tgaactggac ctcggggtct tcctggctca cgtccaccac cacgcacgtg acctcagggg     5580

tccgggagat catgagagtg tccttgggtt ttggggggaa caggaagact gatggtcccc     5640

ccaggaactc aggtgctggg catggtgggc atgggggacc atatttggac tcgttgaacc     5700

gtccctcgcg aaaaagtttc tttaaatgta agagcaggtc ctttacaaac tgggccacct     5760

cgattttggt gtctcggaca tgcaagctgg aaaactgccc agctgagacc ttgtgcgggc     5820

agaatccgct cagcatcctc tgggtcttct cgatggcact gcagcctgac acgttgatca     5880

gggattccag ggctgcacag tacatgccag ctgtcaggtt gatgctccat accatgctgc     5940

cattgcagag cggagccttc tggttctggg tgatgttgac cagctcctca atgaggtacc     6000

tgagggctgt agagggaggc acagggcctg ggatcaggag gaatgctggg tgtggtaact     6060

cacagagcag aaggcttgtc accaggagaa gcatggtggc ggctctaggg tgatctcagc     6120

tgtaggaaag agaagaaggt tagtagtcga cgtgtccctc tcgatgaatc cgtatcaatt     6180

gtgagcgctc acaagtcaac actctttttg ataaatctag tagatatcac ttacgtaggc     6240

gccggtcaca gcttggatct gtaacggcgc agaacagaaa acgaaacaaa gacgtagagt     6300

tgagcaagca gggtcaggca aagcgtggag agccggctga gtctaggtag gctccaaggg     6360

agcgccggac aaaggcccgg tctcgacctg agctttaaac ttacctagac ggcggacgca     6420

gttcaggagg caccacaggc gggaggcggc agaacgcgac tcaaccggcg tggatggcgg     6480

cctcaggtag ggcggcgggc gcgtgaagga gagatgcgag cccctcgaag cttcagctgt     6540

gttctggcgg caaacccgtt gcgaaaaaga acgttcacgg cgactactgc acttatatac     6600

ggttctcccc caccctcggg aaaaaggcgg agccagtaca cgacatcact ttcccagttt     6660

accccgcgcc accttctcta ggcaccggtt caattgccga cccctccccc caacttctcg     6720

gggactgtgg gcgatgtgcg ctctgcccac tgacgggcac cggagcgatc gcagatcctt     6780

cga                                                                   6783


<210>  17
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg 
            20                  25                  30          


Tyr Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro 
        35                  40                  45              


Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met 
    50                  55                  60                  


Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala 
65                  70                  75                  80  


Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val 
                85                  90                  95      


Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu 
            100                 105                 110         


Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe 
        115                 120                 125             


Arg Glu Gly Arg Phe Asn Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    130                 135                 140                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            180                 185                 190         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            260                 265                 270         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Ala Leu Ile Val 
        355                 360                 365             


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
    370                 375                 380                 


Phe Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210>  18
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  selection/ suicide fusion coding region containing herpes simplex
       virus and E.coli sequences

<400>  18

Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Ala Lys Phe Leu Ile 
1               5                   10                  15      


Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 
            20                  25                  30          


Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 
        35                  40                  45              


Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 
    50                  55                  60                  


Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 
65                  70                  75                  80  


Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 
                85                  90                  95      


Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 
            100                 105                 110         


Gln Pro Val Ala Glu Leu Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 
        115                 120                 125             


Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 
    130                 135                 140                 


Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 
145                 150                 155                 160 


His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 
                165                 170                 175     


Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 
            180                 185                 190         


His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 
        195                 200                 205             


Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 
    210                 215                 220                 


Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 
225                 230                 235                 240 


Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 
                245                 250                 255     


Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 
            260                 265                 270         


Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 
        275                 280                 285             


Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 
    290                 295                 300                 


Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 
305                 310                 315                 320 


Cys Val Glu Val Ala Ser Ala Phe Asp Gln Ala Ala Arg Ser Arg Gly 
                325                 330                 335     


His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln Gln Glu Ala 
            340                 345                 350         


Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr Leu Leu Arg Val Tyr 
        355                 360                 365             


Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr Gln Leu Leu 
    370                 375                 380                 


Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro Glu Pro Met 
385                 390                 395                 400 


Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr Ile Ala Asn Ile Tyr 
                405                 410                 415     


Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala Gly Asp Ala 
            420                 425                 430         


Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly Met Pro Tyr Ala 
        435                 440                 445             


Val Thr Asp Ala Val Leu Ala Pro His Ile Gly Gly Glu Ala Gly Ser 
    450                 455                 460                 


Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe Asp Arg His Pro 
465                 470                 475                 480 


Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met Gly Ser 
                485                 490                 495     


Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile Pro Pro Thr 
            500                 505                 510         


Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu Asp Arg His 
        515                 520                 525             


Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg Leu Asp Leu 
    530                 535                 540                 


Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu Leu Ala Asn Thr 
545                 550                 555                 560 


Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg Glu Asp Trp Gly Gln 
                565                 570                 575     


Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala Glu Pro Gln Ser Asn 
            580                 585                 590         


Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu Phe Thr Leu Phe Arg 
        595                 600                 605             


Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr Asn Val Phe Ala 
    610                 615                 620                 


Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg Ser Met His Val Phe 
625                 630                 635                 640 


Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg Asp Ala Leu Leu 
                645                 650                 655     


Gln Leu Thr Ser Gly Met Val Gln Thr His Val Thr Thr Pro Gly Ser 
            660                 665                 670         


Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala Arg Glu Met Gly 
        675                 680                 685             


Glu Ala Asn 
    690     


<210>  19
<211>  6770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  alternate plasmid DNA vector incorporating human, simian virus 
       40, E. coli, cytomegalovirus and bovine sequences

<400>  19
tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt       60

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg      120

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga      180

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag      240

aacacagctg aagcttcgag gggctcgcat ctctccttca cgcgcccgcc gccctacctg      300

aggccgccat ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg      360

aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg agaccgggcc tttgtccggc      420

gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga ccctgcttgc      480

tcaactctac gtctttgttt cgttttctgt tctgcgccgt tacagatcca agctgtgacc      540

ggcgcctacg taagtgatat ctactagatt tatcaaaaag agtgttgact tgtgagcgct      600

cacaattgat acggattcat cgagagggac acgtcgacta ctaaccttct tctctttcct      660

acagctgaga tcaccctaga gccgccacca tgcttctcct ggtgacaagc cttctgctct      720

gtgagttacc acacccagca ttcctcctga tcccaggccc tgtgcctccc tctacagccc      780

tcaggtacct cattgaggag ctggtcaaca tcacccagaa ccagaaggct ccgctctgca      840

atggcagcat ggtatggagc atcaacctga cagctggcat gtactgtgca gccctggaat      900

ccctgatcaa cgtgtcaggc tgcagtgcca tcgagaagac ccagaggatg ctgagcggat      960

tctgcccgca caaggtctca gctgggcagt tttccagctt gcatgtccga gacaccaaaa     1020

tcgaggtggc ccagtttgta aaggacctgc tcttacattt aaagaaactt tttcgcgagg     1080

gacggttcaa cgagtccaaa tatggtcccc catgcccacc atgcccagca cctgagttcc     1140

tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc atgatctccc     1200

ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc gaggtccagt     1260

tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc     1320

agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga     1380

acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa     1440

ccatctccaa agccaaaggg cagccccgag agccacaggt gtacaccctg cccccatccc     1500

aggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca     1560

gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc     1620

ctcccgtgct ggactccgac ggctccttct tcctctacag caggctaacc gtggacaaga     1680

gcaggtggca ggaggggaat gtcttctcat gctccgtgat gcatgaggct ctgcacaacc     1740

actacacaca gaagagcctc tccctgtccc taggtaaaat ggccctgatt gtgctggggg     1800

gcgtcgccgg cctcctgctt ttcattgggc taggcatctt cttcagagtg aagttcagca     1860

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     1920

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     1980

ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata     2040

agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc     2100

acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca     2160

tgcaggccct gccccctcgc tgagcggccg gcgaaggagg cctagatcta tcgattgtac     2220

agctagctcg acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag     2280

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt gaaatttgtg     2340

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     2400

gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa     2460

acctctacaa atgtggtaga tccatttaaa tgttagcgaa gaacatgtga gcaaaaggcc     2520

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     2580

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     2640

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     2700

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat     2760

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     2820

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     2880

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     2940

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     3000

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     3060

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     3120

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     3180

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatggct agttaattaa     3240

gctgcaataa acaatcatta ttttcattgg atctgtgtgt tggttttttg tgtgggcttg     3300

ggggaggggg aggccagaat gactccaaga gctacaggaa ggcaggtcag agaccccact     3360

ggacaaacag tggctggact ctgcaccata acacacaatc aacaggggag tgagctggat     3420

cgagctagag tccgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga     3480

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt     3540

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt     3600

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca     3660

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt     3720

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt     3780

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca     3840

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg     3900

cggtaggcgt gtacggtggg aggtctatat aagcagagct cgtttagtga accgtcagat     3960

cgcctggaga cgccatccac gctgttttga cctccataga agacaccggg accgatccag     4020

cctccgcggc cgggaacggt gcattggaac gcggattccc cgtgccaaga gtgacgtaag     4080

taccgcctat agagtctata ggcccaccta gttgtgaccg gcgcctagtg ttgacaatta     4140

atcatcggca tagtataata cgactcacta taggagggcc accatgtcga ctactaacct     4200

tcttctcttt cctacagctg agatcaccgg taggagggcc atcatgaaaa agcctgaact     4260

caccgcgacg tctgtcgcga agtttctgat cgaaaagttc gacagcgtct ccgacctgat     4320

gcagctctcg gagggcgaag aatctcgtgc tttcagcttc gatgtaggag ggcgtggata     4380

tgtcctgcgg gtaaatagct gcgccgatgg tttctacaaa gatcgttatg tttatcggca     4440

ctttgcatcg gccgcgctcc cgattccgga agtgcttgac attggggaat tcagcgagag     4500

cctgacctat tgcatctccc gccgtgcaca gggtgtcacg ttgcaagacc tgcctgaaac     4560

cgaactgccc gctgttctgc aacccgtcgc ggagctcatg gatgcgatcg ctgcggccga     4620

tcttagccag acgagcgggt tcggcccatt cggaccgcaa ggaatcggtc aatacactac     4680

atggcgtgat ttcatatgcg cgattgctga tccccatgtg tatcactggc aaactgtgat     4740

ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat gagctgatgc tttgggccga     4800

ggactgcccc gaagtccggc acctcgtgca cgcggatttc ggctccaaca atgtcctgac     4860

ggacaatggc cgcataacag cggtcattga ctggagcgag gcgatgttcg gggattccca     4920

atacgaggtc gccaacatct tcttctggag gccgtggttg gcttgtatgg agcagcagac     4980

gcgctacttc gagcggaggc atccggagct tgcaggatcg ccgcggctcc gggcgtatat     5040

gctccgcatt ggtcttgacc aactctatca gagcttggtt gacggcaatt tcgatgatgc     5100

agcttgggcg cagggtcgat gcgacgcaat cgtccgatcc ggagccggga ctgtcgggcg     5160

tacacaaatc gcccgcagaa gcgcggccgt ctggaccgat ggctgtgtag aagtcgcgtc     5220

tgcgttcgac caggctgcgc gttctcgcgg ccatagcaac cgacgtacgg cgttgcgccc     5280

tcgccggcag caagaagcca cggaagtccg cccggagcag aaaatgccca cgctactgcg     5340

ggtttatata gacggtcccc acgggatggg gaaaaccacc accacgcaac tgctggtggc     5400

cctgggttcg cgcgacgata tcgtctacgt acccgagccg atgacttact ggcgggtgct     5460

gggggcttcc gagacaatcg cgaacatcta caccacacaa caccgcctcg accagggtga     5520

gatatcggcc ggggacgcgg cggtggtaat gacaagcgcc cagataacaa tgggcatgcc     5580

ttatgccgtg accgacgccg ttctggctcc tcatatcggg ggggaggctg ggagctcaca     5640

tgccccgccc ccggccctca ccctcatctt cgaccgccat cccatcgccg ccctcctgtg     5700

ctacccggcc gcgcggtacc ttatgggcag catgaccccc caggccgtgc tggcgttcgt     5760

ggccctcatc ccgccgacct tgcccggcac caacatcgtg cttggggccc ttccggagga     5820

cagacacatc gaccgcctgg ccaaacgcca gcgccccggc gagcggctgg acctggctat     5880

gctggctgcg attcgccgcg tttacgggct acttgccaat acggtgcggt atctgcagtg     5940

cggcgggtcg tggcgggagg actggggaca gctttcgggg acggccgtgc cgccccaggg     6000

tgccgagccc cagagcaacg cgggcccacg accccatatc ggggacacgt tatttaccct     6060

gtttcgggcc cccgagttgc tggcccccaa cggcgacctg tataacgtgt ttgcctgggc     6120

cttggacgtc ttggccaaac gcctccgttc catgcacgtc tttatcctgg attacgacca     6180

atcgcccgcc ggctgccggg acgccctgct gcaacttacc tccgggatgg tccagaccca     6240

cgtcaccacc cccggctcca taccgacgat atgcgacctg gcgcgcacgt ttgcccggga     6300

gatgggggag gctaactgag tcgagaattc gctagagggc cctattctat agtgtcacct     6360

aaatgctaga gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     6420

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     6480

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     6540

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg cgcagggccc     6600

aattgctcga gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt     6660

ttgtgtgaat cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta     6720

gcaaaatagg ctgtccccag tgcaagtgca ggtgccagaa catttctcta                6770


<210>  20
<211>  6770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  alternate plasmid DNA vector incorporating human, simian virus 
       40, E. coli, cytomegalovirus and bovine sequences

<400>  20
tagagaaatg ttctggcacc tgcacttgca ctggggacag cctattttgc tagtttgttt       60

tgtttcgttt tgttttgatg gagagcgtat gttagttacg attcacacaa aaaaccaaca      120

cacagatgta atgaaaataa agatatttta ttgcggccgc tcgagcaatt gggccctgcg      180

catgcctgct attgtcttcc caatcctccc ccttgctgtc ctgccccacc ccacccccca      240

gaatagaatg acacctactc agacaatgcg atgcaatttc ctcattttat taggaaagga      300

cagtgggagt ggcaccttcc agggtcaagg aaggcacggg ggaggggcaa acaacagatg      360

gctggcaact agaaggcaca gtcgaggctg atcagcgagc tctagcattt aggtgacact      420

atagaatagg gccctctagc gaattctcga ctcagttagc ctcccccatc tcccgggcaa      480

acgtgcgcgc caggtcgcat atcgtcggta tggagccggg ggtggtgacg tgggtctgga      540

ccatcccgga ggtaagttgc agcagggcgt cccggcagcc ggcgggcgat tggtcgtaat      600

ccaggataaa gacgtgcatg gaacggaggc gtttggccaa gacgtccaag gcccaggcaa      660

acacgttata caggtcgccg ttgggggcca gcaactcggg ggcccgaaac agggtaaata      720

acgtgtcccc gatatggggt cgtgggcccg cgttgctctg gggctcggca ccctggggcg      780

gcacggccgt ccccgaaagc tgtccccagt cctcccgcca cgacccgccg cactgcagat      840

accgcaccgt attggcaagt agcccgtaaa cgcggcgaat cgcagccagc atagccaggt      900

ccagccgctc gccggggcgc tggcgtttgg ccaggcggtc gatgtgtctg tcctccggaa      960

gggccccaag cacgatgttg gtgccgggca aggtcggcgg gatgagggcc acgaacgcca     1020

gcacggcctg gggggtcatg ctgcccataa ggtaccgcgc ggccgggtag cacaggaggg     1080

cggcgatggg atggcggtcg aagatgaggg tgagggccgg gggcggggca tgtgagctcc     1140

cagcctcccc cccgatatga ggagccagaa cggcgtcggt cacggcataa ggcatgccca     1200

ttgttatctg ggcgcttgtc attaccaccg ccgcgtcccc ggccgatatc tcaccctggt     1260

cgaggcggtg ttgtgtggtg tagatgttcg cgattgtctc ggaagccccc agcacccgcc     1320

agtaagtcat cggctcgggt acgtagacga tatcgtcgcg cgaacccagg gccaccagca     1380

gttgcgtggt ggtggttttc cccatcccgt ggggaccgtc tatataaacc cgcagtagcg     1440

tgggcatttt ctgctccggg cggacttccg tggcttcttg ctgccggcga gggcgcaacg     1500

ccgtacgtcg gttgctatgg ccgcgagaac gcgcagcctg gtcgaacgca gacgcgactt     1560

ctacacagcc atcggtccag acggccgcgc ttctgcgggc gatttgtgta cgcccgacag     1620

tcccggctcc ggatcggacg attgcgtcgc atcgaccctg cgcccaagct gcatcatcga     1680

aattgccgtc aaccaagctc tgatagagtt ggtcaagacc aatgcggagc atatacgccc     1740

ggagccgcgg cgatcctgca agctccggat gcctccgctc gaagtagcgc gtctgctgct     1800

ccatacaagc caaccacggc ctccagaaga agatgttggc gacctcgtat tgggaatccc     1860

cgaacatcgc ctcgctccag tcaatgaccg ctgttatgcg gccattgtcc gtcaggacat     1920

tgttggagcc gaaatccgcg tgcacgaggt gccggacttc ggggcagtcc tcggcccaaa     1980

gcatcagctc atcgagagcc tgcgcgacgg acgcactgac ggtgtcgtcc atcacagttt     2040

gccagtgata cacatgggga tcagcaatcg cgcatatgaa atcacgccat gtagtgtatt     2100

gaccgattcc ttgcggtccg aatgggccga acccgctcgt ctggctaaga tcggccgcag     2160

cgatcgcatc catgagctcc gcgacgggtt gcagaacagc gggcagttcg gtttcaggca     2220

ggtcttgcaa cgtgacaccc tgtgcacggc gggagatgca ataggtcagg ctctcgctga     2280

attccccaat gtcaagcact tccggaatcg ggagcgcggc cgatgcaaag tgccgataaa     2340

cataacgatc tttgtagaaa ccatcggcgc agctatttac ccgcaggaca tatccacgcc     2400

ctcctacatc gaagctgaaa gcacgagatt cttcgccctc cgagagctgc atcaggtcgg     2460

agacgctgtc gaacttttcg atcagaaact tcgcgacaga cgtcgcggtg agttcaggct     2520

ttttcatgat ggccctccta ccggtgatct cagctgtagg aaagagaaga aggttagtag     2580

tcgacatggt ggccctccta tagtgagtcg tattatacta tgccgatgat taattgtcaa     2640

cactaggcgc cggtcacaac taggtgggcc tatagactct ataggcggta cttacgtcac     2700

tcttggcacg gggaatccgc gttccaatgc accgttcccg gccgcggagg ctggatcggt     2760

cccggtgtct tctatggagg tcaaaacagc gtggatggcg tctccaggcg atctgacggt     2820

tcactaaacg agctctgctt atatagacct cccaccgtac acgcctaccg cccatttgcg     2880

tcaatggggc ggagttgtta cgacattttg gaaagtcccg ttgattttgg tgccaaaaca     2940

aactcccatt gacgtcaatg gggtggagac ttggaaatcc ccgtgagtca aaccgctatc     3000

cacgcccatt gatgtactgc caaaaccgca tcaccatggt aatagcgatg actaatacgt     3060

agatgtactg ccaagtagga aagtcccata aggtcatgta ctgggcataa tgccaggcgg     3120

gccatttacc gtcattgacg tcaatagggg gcgtacttgg catatgatac acttgatgta     3180

ctgccaagtg ggcagtttac cgtaaatact ccacccattg acgtcaatgg aaagtcccta     3240

ttggcgttac tatgggaaca tacgtcatta ttgacgtcaa tgggcggggg tcgttgggcg     3300

gtcagccagg cgggccattt accgtaagtt atgtaacgga ctctagctcg atccagctca     3360

ctcccctgtt gattgtgtgt tatggtgcag agtccagcca ctgtttgtcc agtggggtct     3420

ctgacctgcc ttcctgtagc tcttggagtc attctggcct ccccctcccc caagcccaca     3480

caaaaaacca acacacagat ccaatgaaaa taatgattgt ttattgcagc ttaattaact     3540

agccatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     3600

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     3660

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     3720

tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc     3780

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     3840

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     3900

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     3960

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag     4020

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     4080

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     4140

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     4200

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     4260

tcacatgttc ttcgctaaca tttaaatgga tctaccacat ttgtagaggt tttacttgct     4320

ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt     4380

gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc     4440

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4500

gttgtggttt gtccaaactc atcaatgtat cttatcatgt cgagctagct gtacaatcga     4560

tagatctagg cctccttcgc cggccgctca gcgagggggc agggcctgca tgtgaagggc     4620

gtcgtaggtg tccttggtgg ctgtactgag accctggtaa aggccatcgt gccccttgcc     4680

cctccggcgc tcgcctttca tcccaatctc actgtaggcc tccgccatct tatctttctg     4740

cagttcattg tacaggcctt cctgagggtt cttccttctc ggctttcccc ccatctcagg     4800

gtcccggcca cgtctcttgt ccaaaacatc gtactcctct cttcgtccta gattgagctc     4860

gttatagagc tggttctggc cctgctggta cgcgggggcg tctgcgctcc tgctgaactt     4920

cactctgaag aagatgccta gcccaatgaa aagcaggagg ccggcgacgc cccccagcac     4980

aatcagggcc attttaccta gggacaggga gaggctcttc tgtgtgtagt ggttgtgcag     5040

agcctcatgc atcacggagc atgagaagac attcccctcc tgccacctgc tcttgtccac     5100

ggttagcctg ctgtagagga agaaggagcc gtcggagtcc agcacgggag gcgtggtctt     5160

gtagttgttc tccggctgcc cattgctctc ccactccacg gcgatgtcgc tggggtagaa     5220

gcctttgacc aggcaggtca ggctgacctg gttcttggtc atctcctcct gggatggggg     5280

cagggtgtac acctgtggct ctcggggctg ccctttggct ttggagatgg ttttctcgat     5340

ggaggacggg aggcctttgt tggagacctt gcacttgtac tccttgccgt tcagccagtc     5400

ctggtgcagg acggtgagga cgctgaccac acggtacgtg ctgttgaact gctcctcccg     5460

cggctttgtc ttggcattat gcacctccac gccatccacg taccagttga actggacctc     5520

ggggtcttcc tggctcacgt ccaccaccac gcacgtgacc tcaggggtcc gggagatcat     5580

gagagtgtcc ttgggttttg gggggaacag gaagactgat ggtcccccca ggaactcagg     5640

tgctgggcat ggtgggcatg ggggaccata tttggactcg ttgaaccgtc cctcgcgaaa     5700

aagtttcttt aaatgtaaga gcaggtcctt tacaaactgg gccacctcga ttttggtgtc     5760

tcggacatgc aagctggaaa actgcccagc tgagaccttg tgcgggcaga atccgctcag     5820

catcctctgg gtcttctcga tggcactgca gcctgacacg ttgatcaggg attccagggc     5880

tgcacagtac atgccagctg tcaggttgat gctccatacc atgctgccat tgcagagcgg     5940

agccttctgg ttctgggtga tgttgaccag ctcctcaatg aggtacctga gggctgtaga     6000

gggaggcaca gggcctggga tcaggaggaa tgctgggtgt ggtaactcac agagcagaag     6060

gcttgtcacc aggagaagca tggtggcggc tctagggtga tctcagctgt aggaaagaga     6120

agaaggttag tagtcgacgt gtccctctcg atgaatccgt atcaattgtg agcgctcaca     6180

agtcaacact ctttttgata aatctagtag atatcactta cgtaggcgcc ggtcacagct     6240

tggatctgta acggcgcaga acagaaaacg aaacaaagac gtagagttga gcaagcaggg     6300

tcaggcaaag cgtggagagc cggctgagtc taggtaggct ccaagggagc gccggacaaa     6360

ggcccggtct cgacctgagc tttaaactta cctagacggc ggacgcagtt caggaggcac     6420

cacaggcggg aggcggcaga acgcgactca accggcgtgg atggcggcct caggtagggc     6480

ggcgggcgcg tgaaggagag atgcgagccc ctcgaagctt cagctgtgtt ctggcggcaa     6540

acccgttgcg aaaaagaacg ttcacggcga ctactgcact tatatacggt tctcccccac     6600

cctcgggaaa aaggcggagc cagtacacga catcactttc ccagtttacc ccgcgccacc     6660

ttctctaggc accggttcaa ttgccgaccc ctccccccaa cttctcgggg actgtgggcg     6720

atgtgcgctc tgcccactga cgggcaccgg agcgatcgca gatccttcga                6770


<210>  21
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Ala Lys Phe Leu Ile 
1               5                   10                  15      


Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 
            20                  25                  30          


Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 
        35                  40                  45              


Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 
    50                  55                  60                  


Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 
65                  70                  75                  80  


Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 
                85                  90                  95      


Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 
            100                 105                 110         


Gln Pro Val Ala Glu Leu Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 
        115                 120                 125             


Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 
    130                 135                 140                 


Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 
145                 150                 155                 160 


His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 
                165                 170                 175     


Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 
            180                 185                 190         


His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 
        195                 200                 205             


Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 
    210                 215                 220                 


Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 
225                 230                 235                 240 


Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 
                245                 250                 255     


Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 
            260                 265                 270         


Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 
        275                 280                 285             


Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 
    290                 295                 300                 


Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 
305                 310                 315                 320 


Cys Val Glu Val Ala Ser Ala Phe Asp Gln Ala Ala Arg Ser Arg Gly 
                325                 330                 335     


His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln Gln Glu Ala 
            340                 345                 350         


Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr Leu Leu Arg Val Tyr 
        355                 360                 365             


Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr Gln Leu Leu 
    370                 375                 380                 


Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro Glu Pro Met 
385                 390                 395                 400 


Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr Ile Ala Asn Ile Tyr 
                405                 410                 415     


Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala Gly Asp Ala 
            420                 425                 430         


Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly Met Pro Tyr Ala 
        435                 440                 445             


Val Thr Asp Ala Val Leu Ala Pro His Ile Gly Gly Glu Ala Gly Ser 
    450                 455                 460                 


Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe Asp Arg His Pro 
465                 470                 475                 480 


Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met Gly Ser 
                485                 490                 495     


Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile Pro Pro Thr 
            500                 505                 510         


Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu Asp Arg His 
        515                 520                 525             


Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg Leu Asp Leu 
    530                 535                 540                 


Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu Leu Ala Asn Thr 
545                 550                 555                 560 


Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg Glu Asp Trp Gly Gln 
                565                 570                 575     


Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala Glu Pro Gln Ser Asn 
            580                 585                 590         


Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu Phe Thr Leu Phe Arg 
        595                 600                 605             


Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr Asn Val Phe Ala 
    610                 615                 620                 


Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg Ser Met His Val Phe 
625                 630                 635                 640 


Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg Asp Ala Leu Leu 
                645                 650                 655     


Gln Leu Thr Ser Gly Met Val Gln Thr His Val Thr Thr Pro Gly Ser 
            660                 665                 670         


Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala Arg Glu Met Gly 
        675                 680                 685             


Glu Ala Asn 
    690  


<210>  22
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL13 cytokine fused to Fc:zeta

<400>  22

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg 
            20                  25                  30          


Tyr Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro 
        35                  40                  45              


Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met 
    50                  55                  60                  


Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala 
65                  70                  75                  80  


Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val 
                85                  90                  95      


Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu 
            100                 105                 110         


Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe 
        115                 120                 125             


Arg Glu Gly Arg Phe Asn Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    130                 135                 140                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            180                 185                 190         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            260                 265                 270         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Ala Leu Ile Val 
        355                 360                 365             


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
    370                 375                 380                 


Phe Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
       

<210>  23
<211>  6770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL13-Zeta_diihyTk-pMG

<400>  23
caccctagag ccgccaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca       60

cacccagcat tcctcctgat cccaggccct gtgcctccct ctacagccct caggtacctc      120

attgaggagc tggtcaacat cacccagaac cagaaggctc cgctctgcaa tggcagcatg      180

gtatggagca tcaacctgac agctggcatg tactgtgcag ccctggaatc cctgatcaac      240

gtgtcaggct gcagtgccat cgagaagacc cagaggatgc tgagcggatt ctgcccgcac      300

aaggtctcag ctgggcagtt ttccagcttg catgtccgag acaccaaaat cgaggtggcc      360

cagtttgtaa aggacctgct cttacattta aagaaacttt ttcgcgaggg acggttcaac      420

gagtccaaat atggtccccc atgcccacca tgcccagcac ctgagttcct ggggggacca      480

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      540

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      600

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      660

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      720

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa      780

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg      840

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc      900

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      960

gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag     1020

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag     1080

aagagcctct ccctgtccct aggtaaaatg gccctgattg tgctgggggg cgtcgccggc     1140

ctcctgcttt tcattgggct aggcatcttc ttcagagtga agttcagcag gagcgcagac     1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1500

ccccctcgct gagcggccgg cgaaggaggc ctagatctat cgattgtaca gctagctcga     1560

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     1620

ctttatttgt gaaatttgtg atgctattgc tttatttgtg aaatttgtga tgctattgct     1680

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     1740

atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa     1800

tgtggtagat ccatttaaat gttagcgaag aacatgtgag caaaaggcca gcaaaaggcc     1860

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     1920

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1980

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     2040

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcaatg ctcacgctgt     2100

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     2160

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     2220

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     2280

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     2340

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     2400

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     2460

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     2520

tggaacgaaa actcacgtta agggattttg gtcatggcta gttaattaag ctgcaataaa     2580

caatcattat tttcattgga tctgtgtgtt ggttttttgt gtgggcttgg gggaggggga     2640

ggccagaatg actccaagag ctacaggaag gcaggtcaga gaccccactg gacaaacagt     2700

ggctggactc tgcaccataa cacacaatca acaggggagt gagctggatc gagctagagt     2760

ccgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat     2820

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc     2880

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc     2940

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt     3000

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta     3060

ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg     3120

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac     3180

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg     3240

tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac     3300

gccatccacg ctgttttgac ctccatagaa gacaccggga ccgatccagc ctccgcggcc     3360

gggaacggtg cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata     3420

gagtctatag gcccacctag ttgtgaccgg cgcctagtgt tgacaattaa tcatcggcat     3480

agtataatac gactcactat aggagggcca ccatgtcgac tactaacctt cttctctttc     3540

ctacagctga gatcaccggt aggagggcca tcatgaaaaa gcctgaactc accgcgacgt     3600

ctgtcgcgaa gtttctgatc gaaaagttcg acagcgtctc cgacctgatg cagctctcgg     3660

agggcgaaga atctcgtgct ttcagcttcg atgtaggagg gcgtggatat gtcctgcggg     3720

taaatagctg cgccgatggt ttctacaaag atcgttatgt ttatcggcac tttgcatcgg     3780

ccgcgctccc gattccggaa gtgcttgaca ttggggaatt cagcgagagc ctgacctatt     3840

gcatctcccg ccgtgcacag ggtgtcacgt tgcaagacct gcctgaaacc gaactgcccg     3900

ctgttctgca acccgtcgcg gagctcatgg atgcgatcgc tgcggccgat cttagccaga     3960

cgagcgggtt cggcccattc ggaccgcaag gaatcggtca atacactaca tggcgtgatt     4020

tcatatgcgc gattgctgat ccccatgtgt atcactggca aactgtgatg gacgacaccg     4080

tcagtgcgtc cgtcgcgcag gctctcgatg agctgatgct ttgggccgag gactgccccg     4140

aagtccggca cctcgtgcac gcggatttcg gctccaacaa tgtcctgacg gacaatggcc     4200

gcataacagc ggtcattgac tggagcgagg cgatgttcgg ggattcccaa tacgaggtcg     4260

ccaacatctt cttctggagg ccgtggttgg cttgtatgga gcagcagacg cgctacttcg     4320

agcggaggca tccggagctt gcaggatcgc cgcggctccg ggcgtatatg ctccgcattg     4380

gtcttgacca actctatcag agcttggttg acggcaattt cgatgatgca gcttgggcgc     4440

agggtcgatg cgacgcaatc gtccgatccg gagccgggac tgtcgggcgt acacaaatcg     4500

cccgcagaag cgcggccgtc tggaccgatg gctgtgtaga agtcgcgtct gcgttcgacc     4560

aggctgcgcg ttctcgcggc catagcaacc gacgtacggc gttgcgccct cgccggcagc     4620

aagaagccac ggaagtccgc ccggagcaga aaatgcccac gctactgcgg gtttatatag     4680

acggtcccca cgggatgggg aaaaccacca ccacgcaact gctggtggcc ctgggttcgc     4740

gcgacgatat cgtctacgta cccgagccga tgacttactg gcgggtgctg ggggcttccg     4800

agacaatcgc gaacatctac accacacaac accgcctcga ccagggtgag atatcggccg     4860

gggacgcggc ggtggtaatg acaagcgccc agataacaat gggcatgcct tatgccgtga     4920

ccgacgccgt tctggctcct catatcgggg gggaggctgg gagctcacat gccccgcccc     4980

cggccctcac cctcatcttc gaccgccatc ccatcgccgc cctcctgtgc tacccggccg     5040

cgcggtacct tatgggcagc atgacccccc aggccgtgct ggcgttcgtg gccctcatcc     5100

cgccgacctt gcccggcacc aacatcgtgc ttggggccct tccggaggac agacacatcg     5160

accgcctggc caaacgccag cgccccggcg agcggctgga cctggctatg ctggctgcga     5220

ttcgccgcgt ttacgggcta cttgccaata cggtgcggta tctgcagtgc ggcgggtcgt     5280

ggcgggagga ctggggacag ctttcgggga cggccgtgcc gccccagggt gccgagcccc     5340

agagcaacgc gggcccacga ccccatatcg gggacacgtt atttaccctg tttcgggccc     5400

ccgagttgct ggcccccaac ggcgacctgt ataacgtgtt tgcctgggcc ttggacgtct     5460

tggccaaacg cctccgttcc atgcacgtct ttatcctgga ttacgaccaa tcgcccgccg     5520

gctgccggga cgccctgctg caacttacct ccgggatggt ccagacccac gtcaccaccc     5580

ccggctccat accgacgata tgcgacctgg cgcgcacgtt tgcccgggag atgggggagg     5640

ctaactgagt cgagaattcg ctagagggcc ctattctata gtgtcaccta aatgctagag     5700

ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     5760

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     5820

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     5880

acagcaaggg ggaggattgg gaagacaata gcaggcatgc gcagggccca attgctcgag     5940

cggccgcaat aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtgaatc     6000

gtaactaaca tacgctctcc atcaaaacaa aacgaaacaa aacaaactag caaaataggc     6060

tgtccccagt gcaagtgcag gtgccagaac atttctctat cgaaggatct gcgatcgctc     6120

cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg     6180

ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt     6240

cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt     6300

cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacagctga agcttcgagg     6360

ggctcgcatc tctccttcac gcgcccgccg ccctacctga ggccgccatc cacgccggtt     6420

gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga actgcgtccg ccgtctaggt     6480

aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg ctcccttgga gcctacctag     6540

actcagccgg ctctccacgc tttgcctgac cctgcttgct caactctacg tctttgtttc     6600

gttttctgtt ctgcgccgtt acagatccaa gctgtgaccg gcgcctacgt aagtgatatc     6660

tactagattt atcaaaaaga gtgttgactt gtgagcgctc acaattgata cggattcatc     6720

gagagggaca cgtcgactac taaccttctt ctctttccta cagctgagat                6770


<210>  24
<211>  6785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid DNA vector incorporating human, simian virus 40, E. coli,
       cytomegalovirus and bovine sequences

<400>  24
tcgaaggatc tgcgatcgct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt       60

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg      120

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga      180

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag      240

aacacagctg aagcttcgag gggctcgcat ctctccttca cgcgcccgcc gccctacctg      300

aggccgccat ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg      360

aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg agaccgggcc tttgtccggc      420

gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga ccctgcttgc      480

tcaactctac gtctttgttt cgttttctgt tctgcgccgt tacagatcca agctgtgacc      540

ggcgcctacg taagtgatat ctactagatt tatcaaaaag agtgttgact tgtgagcgct      600

cacaattgat acttagattc atcgagaggg acacgtcgac tactaacctt cttctctttc      660

ctacagctga gatcacccta gagccgccac catgcttctc ctggtgacaa gccttctgct      720

ctgtgagtta ccacacccag cattcctcct gatcccaggc cctgtgcctc cctctacagc      780

cctcaggtac ctcattgagg agctggtcaa catcacccag aaccagaagg ctccgctctg      840

caatggcagc atggtatgga gcatcaacct gacagctggc atgtactgtg cagccctgga      900

atccctgatc aacgtgtcag gctgcagtgc catcgagaag acccagagga tgctgagcgg      960

attctgcccg cacaaggtct cagctgggca gttttccagc ttgcatgtcc gagacaccaa     1020

aatcgaggtg gcccagtttg taaaggacct gctcttacat ttaaagaaac tttttcgcga     1080

gggacggttc aacgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt     1140

cctgggggga ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc     1200

ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca     1260

gttcaactgg tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga     1320

gcagttcaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct     1380

gaacggcaag gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa     1440

aaccatctcc aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc     1500

ccaggaggag atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc     1560

cagcgacatc gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac     1620

gcctcccgtg ctggactccg acggctcctt cttcctctac agcaggctaa ccgtggacaa     1680

gagcaggtgg caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa     1740

ccactacaca cagaagagcc tctccctgtc cctaggtaaa atggccctga ttgtgctggg     1800

gggcgtcgcc ggcctcctgc ttttcattgg gctaggcatc ttcttcagag tgaagttcag     1860

caggagcgca gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa     1920

tctaggacga agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat     1980

ggggggaaag ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga     2040

taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg     2100

gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca     2160

catgcaggcc ctgccccctc gctgagcggc cggcgaagga ggcctagatc tatcgattgt     2220

acagctagct cgacatgata agatacattg atgagtttgg acaaaccaca actagaatgc     2280

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtgaaatttg     2340

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     2400

ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta     2460

aaacctctac aaatgtggta gatccattta aatgttagcg aagaacatgt gagcaaaagg     2520

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     2580

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     2640

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     2700

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     2760

atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     2820

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     2880

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     2940

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     3000

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     3060

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     3120

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     3180

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatgg ctagttaatt     3240

aagctgcaat aaacaatcat tattttcatt ggatctgtgt gttggttttt tgtgtgggct     3300

tgggggaggg ggaggccaga atgactccaa gagctacagg aaggcaggtc agagacccca     3360

ctggacaaac agtggctgga ctctgcacca taacacacaa tcaacagggg agtgagctgg     3420

atcgagctag agtccgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac     3480

gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact     3540

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa     3600

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg     3660

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta     3720

gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg     3780

tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg     3840

caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg     3900

ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt gaaccgtcag     3960

atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc     4020

agcctccgcg gccgggaacg gtgcattgga acgcggattc cccgtgccaa gagtgacgta     4080

agtaccgcct atagagtcta taggcccacc tagttgtgac cggcgcctag tgttgacaat     4140

taatcatcgg catagtatat cggcatagta taatacgact cactatagga gggccaccat     4200

gtcgactact aaccttcttc tctttcctac agctgagatc accggtagga gggccatcat     4260

gaaaaagcct gaactcaccg cgacgtctgt cgcgaagttt ctgatcgaaa agttcgacag     4320

cgtctccgac ctgatgcagc tctcggaggg cgaagaatct cgtgctttca gcttcgatgt     4380

aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc gatggtttct acaaagatcg     4440

ttatgtttat cggcactttg catcggccgc gctcccgatt ccggaagtgc ttgacattgg     4500

ggaattcagc gagagcctga cctattgcat ctcccgccgt gcacagggtg tcacgttgca     4560

agacctgcct gaaaccgaac tgcccgctgt tctgcaaccc gtcgcggagc tcatggatgc     4620

gatcgctgcg gccgatctta gccagacgag cgggttcggc ccattcggac cgcaaggaat     4680

cggtcaatac actacatggc gtgatttcat atgcgcgatt gctgatcccc atgtgtatca     4740

ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc gcgcaggctc tcgatgagct     4800

gatgctttgg gccgaggact gccccgaagt ccggcacctc gtgcacgcgg atttcggctc     4860

caacaatgtc ctgacggaca atggccgcat aacagcggtc attgactgga gcgaggcgat     4920

gttcggggat tcccaatacg aggtcgccaa catcttcttc tggaggccgt ggttggcttg     4980

tatggagcag cagacgcgct acttcgagcg gaggcatccg gagcttgcag gatcgccgcg     5040

gctccgggcg tatatgctcc gcattggtct tgaccaactc tatcagagct tggttgacgg     5100

caatttcgat gatgcagctt gggcgcaggg tcgatgcgac gcaatcgtcc gatccggagc     5160

cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg gccgtctgga ccgatggctg     5220

tgtagaagtc gcgtctgcgt tcgaccaggc tgcgcgttct cgcggccata gcaaccgacg     5280

tacggcgttg cgccctcgcc ggcagcaaga agccacggaa gtccgcccgg agcagaaaat     5340

gcccacgcta ctgcgggttt atatagacgg tccccacggg atggggaaaa ccaccaccac     5400

gcaactgctg gtggccctgg gttcgcgcga cgatatcgtc tacgtacccg agccgatgac     5460

ttactggcgg gtgctggggg cttccgagac aatcgcgaac atctacacca cacaacaccg     5520

cctcgaccag ggtgagatat cggccgggga cgcggcggtg gtaatgacaa gcgcccagat     5580

aacaatgggc atgccttatg ccgtgaccga cgccgttctg gctcctcata tcggggggga     5640

ggctgggagc tcacatgccc cgcccccggc cctcaccctc atcttcgacc gccatcccat     5700

cgccgccctc ctgtgctacc cggccgcgcg gtaccttatg ggcagcatga ccccccaggc     5760

cgtgctggcg ttcgtggccc tcatcccgcc gaccttgccc ggcaccaaca tcgtgcttgg     5820

ggcccttccg gaggacagac acatcgaccg cctggccaaa cgccagcgcc ccggcgagcg     5880

gctggacctg gctatgctgg ctgcgattcg ccgcgtttac gggctacttg ccaatacggt     5940

gcggtatctg cagtgcggcg ggtcgtggcg ggaggactgg ggacagcttt cggggacggc     6000

cgtgccgccc cagggtgccg agccccagag caacgcgggc ccacgacccc atatcgggga     6060

cacgttattt accctgtttc gggcccccga gttgctggcc cccaacggcg acctgtataa     6120

cgtgtttgcc tgggccttgg acgtcttggc caaacgcctc cgttccatgc acgtctttat     6180

cctggattac gaccaatcgc ccgccggctg ccgggacgcc ctgctgcaac ttacctccgg     6240

gatggtccag acccacgtca ccacccccgg ctccataccg acgatatgcg acctggcgcg     6300

cacgtttgcc cgggagatgg gggaggctaa ctgagtcgag aattcgctag agggccctat     6360

tctatagtgt cacctaaatg ctagagctcg ctgatcagcc tcgactgtgc cttctagttg     6420

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     6480

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     6540

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     6600

gcatgcgcag ggcccaattg ctcgagcggc cgcaataaaa tatctttatt ttcattacat     6660

ctgtgtgttg gttttttgtg tgaatcgtaa ctaacatacg ctctccatca aaacaaaacg     6720

aaacaaaaca aactagcaaa ataggctgtc cccagtgcaa gtgcaggtgc cagaacattt     6780

ctcta                                                                 6785


<210>  25
<211>  6785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid DNA vector incorporating human, simian virus 40, E. coli,
       cytomegalovirus and bovine sequences

<400>  25
tagagaaatg ttctggcacc tgcacttgca ctggggacag cctattttgc tagtttgttt       60

tgtttcgttt tgttttgatg gagagcgtat gttagttacg attcacacaa aaaaccaaca      120

cacagatgta atgaaaataa agatatttta ttgcggccgc tcgagcaatt gggccctgcg      180

catgcctgct attgtcttcc caatcctccc ccttgctgtc ctgccccacc ccacccccca      240

gaatagaatg acacctactc agacaatgcg atgcaatttc ctcattttat taggaaagga      300

cagtgggagt ggcaccttcc agggtcaagg aaggcacggg ggaggggcaa acaacagatg      360

gctggcaact agaaggcaca gtcgaggctg atcagcgagc tctagcattt aggtgacact      420

atagaatagg gccctctagc gaattctcga ctcagttagc ctcccccatc tcccgggcaa      480

acgtgcgcgc caggtcgcat atcgtcggta tggagccggg ggtggtgacg tgggtctgga      540

ccatcccgga ggtaagttgc agcagggcgt cccggcagcc ggcgggcgat tggtcgtaat      600

ccaggataaa gacgtgcatg gaacggaggc gtttggccaa gacgtccaag gcccaggcaa      660

acacgttata caggtcgccg ttgggggcca gcaactcggg ggcccgaaac agggtaaata      720

acgtgtcccc gatatggggt cgtgggcccg cgttgctctg gggctcggca ccctggggcg      780

gcacggccgt ccccgaaagc tgtccccagt cctcccgcca cgacccgccg cactgcagat      840

accgcaccgt attggcaagt agcccgtaaa cgcggcgaat cgcagccagc atagccaggt      900

ccagccgctc gccggggcgc tggcgtttgg ccaggcggtc gatgtgtctg tcctccggaa      960

gggccccaag cacgatgttg gtgccgggca aggtcggcgg gatgagggcc acgaacgcca     1020

gcacggcctg gggggtcatg ctgcccataa ggtaccgcgc ggccgggtag cacaggaggg     1080

cggcgatggg atggcggtcg aagatgaggg tgagggccgg gggcggggca tgtgagctcc     1140

cagcctcccc cccgatatga ggagccagaa cggcgtcggt cacggcataa ggcatgccca     1200

ttgttatctg ggcgcttgtc attaccaccg ccgcgtcccc ggccgatatc tcaccctggt     1260

cgaggcggtg ttgtgtggtg tagatgttcg cgattgtctc ggaagccccc agcacccgcc     1320

agtaagtcat cggctcgggt acgtagacga tatcgtcgcg cgaacccagg gccaccagca     1380

gttgcgtggt ggtggttttc cccatcccgt ggggaccgtc tatataaacc cgcagtagcg     1440

tgggcatttt ctgctccggg cggacttccg tggcttcttg ctgccggcga gggcgcaacg     1500

ccgtacgtcg gttgctatgg ccgcgagaac gcgcagcctg gtcgaacgca gacgcgactt     1560

ctacacagcc atcggtccag acggccgcgc ttctgcgggc gatttgtgta cgcccgacag     1620

tcccggctcc ggatcggacg attgcgtcgc atcgaccctg cgcccaagct gcatcatcga     1680

aattgccgtc aaccaagctc tgatagagtt ggtcaagacc aatgcggagc atatacgccc     1740

ggagccgcgg cgatcctgca agctccggat gcctccgctc gaagtagcgc gtctgctgct     1800

ccatacaagc caaccacggc ctccagaaga agatgttggc gacctcgtat tgggaatccc     1860

cgaacatcgc ctcgctccag tcaatgaccg ctgttatgcg gccattgtcc gtcaggacat     1920

tgttggagcc gaaatccgcg tgcacgaggt gccggacttc ggggcagtcc tcggcccaaa     1980

gcatcagctc atcgagagcc tgcgcgacgg acgcactgac ggtgtcgtcc atcacagttt     2040

gccagtgata cacatgggga tcagcaatcg cgcatatgaa atcacgccat gtagtgtatt     2100

gaccgattcc ttgcggtccg aatgggccga acccgctcgt ctggctaaga tcggccgcag     2160

cgatcgcatc catgagctcc gcgacgggtt gcagaacagc gggcagttcg gtttcaggca     2220

ggtcttgcaa cgtgacaccc tgtgcacggc gggagatgca ataggtcagg ctctcgctga     2280

attccccaat gtcaagcact tccggaatcg ggagcgcggc cgatgcaaag tgccgataaa     2340

cataacgatc tttgtagaaa ccatcggcgc agctatttac ccgcaggaca tatccacgcc     2400

ctcctacatc gaagctgaaa gcacgagatt cttcgccctc cgagagctgc atcaggtcgg     2460

agacgctgtc gaacttttcg atcagaaact tcgcgacaga cgtcgcggtg agttcaggct     2520

ttttcatgat ggccctccta ccggtgatct cagctgtagg aaagagaaga aggttagtag     2580

tcgacatggt ggccctccta tagtgagtcg tattatacta tgccgatata ctatgccgat     2640

gattaattgt caacactagg cgccggtcac aactaggtgg gcctatagac tctataggcg     2700

gtacttacgt cactcttggc acggggaatc cgcgttccaa tgcaccgttc ccggccgcgg     2760

aggctggatc ggtcccggtg tcttctatgg aggtcaaaac agcgtggatg gcgtctccag     2820

gcgatctgac ggttcactaa acgagctctg cttatataga cctcccaccg tacacgccta     2880

ccgcccattt gcgtcaatgg ggcggagttg ttacgacatt ttggaaagtc ccgttgattt     2940

tggtgccaaa acaaactccc attgacgtca atggggtgga gacttggaaa tccccgtgag     3000

tcaaaccgct atccacgccc attgatgtac tgccaaaacc gcatcaccat ggtaatagcg     3060

atgactaata cgtagatgta ctgccaagta ggaaagtccc ataaggtcat gtactgggca     3120

taatgccagg cgggccattt accgtcattg acgtcaatag ggggcgtact tggcatatga     3180

tacacttgat gtactgccaa gtgggcagtt taccgtaaat actccaccca ttgacgtcaa     3240

tggaaagtcc ctattggcgt tactatggga acatacgtca ttattgacgt caatgggcgg     3300

gggtcgttgg gcggtcagcc aggcgggcca tttaccgtaa gttatgtaac ggactctagc     3360

tcgatccagc tcactcccct gttgattgtg tgttatggtg cagagtccag ccactgtttg     3420

tccagtgggg tctctgacct gccttcctgt agctcttgga gtcattctgg cctccccctc     3480

ccccaagccc acacaaaaaa ccaacacaca gatccaatga aaataatgat tgtttattgc     3540

agcttaatta actagccatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     3600

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     3660

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     3720

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     3780

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     3840

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     3900

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     3960

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     4020

agcattgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     4080

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     4140

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     4200

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     4260

gctggccttt tgctcacatg ttcttcgcta acatttaaat ggatctacca catttgtaga     4320

ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa     4380

tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag     4440

catcacaaat ttcacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt     4500

tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtcgagcta     4560

gctgtacaat cgatagatct aggcctcctt cgccggccgc tcagcgaggg ggcagggcct     4620

gcatgtgaag ggcgtcgtag gtgtccttgg tggctgtact gagaccctgg taaaggccat     4680

cgtgcccctt gcccctccgg cgctcgcctt tcatcccaat ctcactgtag gcctccgcca     4740

tcttatcttt ctgcagttca ttgtacaggc cttcctgagg gttcttcctt ctcggctttc     4800

cccccatctc agggtcccgg ccacgtctct tgtccaaaac atcgtactcc tctcttcgtc     4860

ctagattgag ctcgttatag agctggttct ggccctgctg gtacgcgggg gcgtctgcgc     4920

tcctgctgaa cttcactctg aagaagatgc ctagcccaat gaaaagcagg aggccggcga     4980

cgccccccag cacaatcagg gccattttac ctagggacag ggagaggctc ttctgtgtgt     5040

agtggttgtg cagagcctca tgcatcacgg agcatgagaa gacattcccc tcctgccacc     5100

tgctcttgtc cacggttagc ctgctgtaga ggaagaagga gccgtcggag tccagcacgg     5160

gaggcgtggt cttgtagttg ttctccggct gcccattgct ctcccactcc acggcgatgt     5220

cgctggggta gaagcctttg accaggcagg tcaggctgac ctggttcttg gtcatctcct     5280

cctgggatgg gggcagggtg tacacctgtg gctctcgggg ctgccctttg gctttggaga     5340

tggttttctc gatggaggac gggaggcctt tgttggagac cttgcacttg tactccttgc     5400

cgttcagcca gtcctggtgc aggacggtga ggacgctgac cacacggtac gtgctgttga     5460

actgctcctc ccgcggcttt gtcttggcat tatgcacctc cacgccatcc acgtaccagt     5520

tgaactggac ctcggggtct tcctggctca cgtccaccac cacgcacgtg acctcagggg     5580

tccgggagat catgagagtg tccttgggtt ttggggggaa caggaagact gatggtcccc     5640

ccaggaactc aggtgctggg catggtgggc atgggggacc atatttggac tcgttgaacc     5700

gtccctcgcg aaaaagtttc tttaaatgta agagcaggtc ctttacaaac tgggccacct     5760

cgattttggt gtctcggaca tgcaagctgg aaaactgccc agctgagacc ttgtgcgggc     5820

agaatccgct cagcatcctc tgggtcttct cgatggcact gcagcctgac acgttgatca     5880

gggattccag ggctgcacag tacatgccag ctgtcaggtt gatgctccat accatgctgc     5940

cattgcagag cggagccttc tggttctggg tgatgttgac cagctcctca atgaggtacc     6000

tgagggctgt agagggaggc acagggcctg ggatcaggag gaatgctggg tgtggtaact     6060

cacagagcag aaggcttgtc accaggagaa gcatggtggc ggctctaggg tgatctcagc     6120

tgtaggaaag agaagaaggt tagtagtcga cgtgtccctc tcgatgaatc taagtatcaa     6180

ttgtgagcgc tcacaagtca acactctttt tgataaatct agtagatatc acttacgtag     6240

gcgccggtca cagcttggat ctgtaacggc gcagaacaga aaacgaaaca aagacgtaga     6300

gttgagcaag cagggtcagg caaagcgtgg agagccggct gagtctaggt aggctccaag     6360

ggagcgccgg acaaaggccc ggtctcgacc tgagctttaa acttacctag acggcggacg     6420

cagttcagga ggcaccacag gcgggaggcg gcagaacgcg actcaaccgg cgtggatggc     6480

ggcctcaggt agggcggcgg gcgcgtgaag gagagatgcg agcccctcga agcttcagct     6540

gtgttctggc ggcaaacccg ttgcgaaaaa gaacgttcac ggcgactact gcacttatat     6600

acggttctcc cccaccctcg ggaaaaaggc ggagccagta cacgacatca ctttcccagt     6660

ttaccccgcg ccaccttctc taggcaccgg ttcaattgcc gacccctccc cccaacttct     6720

cggggactgt gggcgatgtg cgctctgccc actgacgggc accggagcga tcgcagatcc     6780

ttcga                                                                 6785



































							