                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary, Department of Health and Human 
       Services
       McBride, Alison
       Chapman, Sandra
 
<120>  USE OF A ROCK INHIBITOR TO SUSTAIN PRIMARY HUMAN KERATINOCYTES IN
        A PROLIFERATIVE STATE

<130>  4239-82329-02

<150>  US 61/120,272
<151>  2008-12-05

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  6650
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (942)..(5006)

<400>  1
gctggttccc cttccgagcg tccgcgcccc gcatgcgcag tctgccccgg cggtctccgt       60

ttgtttgaac aggaaggcgg acatattagt ccctctcagc ccccctcgcc ccacccccca      120

ggcattcgcc gccgcgactc gccctttccc cggctgggac cgcagcccct cccagaagct      180

cccccatcag cagccgccgg gacccaacta tcgtcttcct cttcgcccgc tctccagcct      240

ttcctctgct aagtctccat cgggcatcga cctcgccctg ccccaccgga caccgtagca      300

gcagccccag cagcgacggg acaaaatggg agagtgaggc tgtcctgcgt ggaccagctc      360

gtggccgaga ctgatcggtg cgtcgggccg ggccgagtag agccggggac gcggggctag      420

accgtctaca gcgcctctga gcggagcggg cccggcccgt ggcccgagcg gcggccgcag      480

ctggcacagc tcctcacccg ccctttgctt tcgcctttcc tcttctccct cccttgttgc      540

ccggagggag tctccaccct gcttctcttt ctctacccgc tcctgcccat ctcgggacgg      600

ggacccctcc atggcgacgg cggccggggc ccgctagact gaagcacctc gccggagcga      660

cgaggctggt ggcgacggcg ctgtcggctg tcgtgagggg ctgccgggtg ggatgcgact      720

ttgggcgtcc gagcggctgt gggtcgctgt tgcccccggc ccggggtctg gagagcggag      780

gtcccctcag tgaggggaag acgggggaac cgggcgcacc tggtgaccct gaggttccgg      840

ctcctccgcc ccgcggctgc gaacccaccg cggaggaagt tggttgaaat tgctttccgc      900

tgctggtgct ggtaagaggg cattgtcaca gcagcagcaa c atg tcg act ggg gac      956
                                              Met Ser Thr Gly Asp         
                                              1               5           

agt ttt gag act cga ttt gaa aaa atg gac aac ctg ctg cgg gat ccc       1004
Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn Leu Leu Arg Asp Pro           
                10                  15                  20                

aaa tcg gaa gtg aat tcg gat tgt ttg ctg gat gga ttg gat gct ttg       1052
Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp Gly Leu Asp Ala Leu           
            25                  30                  35                    

gta tat gat ttg gat ttt cct gcc tta aga aaa aac aaa aat att gac       1100
Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys Asn Lys Asn Ile Asp           
        40                  45                  50                        

aac ttt tta agc aga tat aaa gac aca ata aat aaa atc aga gat tta       1148
Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn Lys Ile Arg Asp Leu           
    55                  60                  65                            

cga atg aaa gct gaa gat tat gaa gta gtg aag gtg att ggt aga ggt       1196
Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys Val Ile Gly Arg Gly           
70                  75                  80                  85            

gca ttt gga gaa gtt caa ttg gta agg cat aaa tcc acc agg aag gta       1244
Ala Phe Gly Glu Val Gln Leu Val Arg His Lys Ser Thr Arg Lys Val           
                90                  95                  100               

tat gct atg aag ctt ctc agc aaa ttt gaa atg ata aag aga tct gat       1292
Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met Ile Lys Arg Ser Asp           
            105                 110                 115                   

tct gct ttt ttc tgg gaa gaa agg gac atc atg gct ttt gcc aac agt       1340
Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met Ala Phe Ala Asn Ser           
        120                 125                 130                       

cct tgg gtt gtt cag ctt ttt tat gca ttc caa gat gat cgt tat ctc       1388
Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln Asp Asp Arg Tyr Leu           
    135                 140                 145                           

tac atg gtg atg gaa tac atg cct ggt gga gat ctt gta aac tta atg       1436
Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp Leu Val Asn Leu Met           
150                 155                 160                 165           

agc aac tat gat gtg cct gaa aaa tgg gca cga ttc tat act gca gaa       1484
Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg Phe Tyr Thr Ala Glu           
                170                 175                 180               

gta gtt ctt gca ttg gat gca atc cat tcc atg ggt ttt att cac aga       1532
Val Val Leu Ala Leu Asp Ala Ile His Ser Met Gly Phe Ile His Arg           
            185                 190                 195                   

gat gtg aag cct gat aac atg ctg ctg gat aaa tct gga cat ttg aag       1580
Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys Ser Gly His Leu Lys           
        200                 205                 210                       

tta gca gat ttt ggt act tgt atg aag atg aat aag gaa ggc atg gta       1628
Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn Lys Glu Gly Met Val           
    215                 220                 225                           

cga tgt gat aca gcg gtt gga aca cct gat tat att tcc cct gaa gta       1676
Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr Ile Ser Pro Glu Val           
230                 235                 240                 245           

tta aaa tcc caa ggt ggt gat ggt tat tat gga aga gaa tgt gac tgg       1724
Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly Arg Glu Cys Asp Trp           
                250                 255                 260               

tgg tcg gtt ggg gta ttt tta tac gaa atg ctt gta ggt gat aca cct       1772
Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu Val Gly Asp Thr Pro           
            265                 270                 275                   

ttt tat gca gat tct ttg gtt gga act tac agt aaa att atg aac cat       1820
Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser Lys Ile Met Asn His           
        280                 285                 290                       

aaa aat tca ctt acc ttt cct gat gat aat gac ata tca aaa gaa gca       1868
Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp Ile Ser Lys Glu Ala           
    295                 300                 305                           

aaa aac ctt att tgt gcc ttc ctt act gac agg gaa gtg agg tta ggg       1916
Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg Glu Val Arg Leu Gly           
310                 315                 320                 325           

cga aat ggt gta gaa gaa atc aaa cga cat ctc ttc ttc aaa aat gac       1964
Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu Phe Phe Lys Asn Asp           
                330                 335                 340               

cag tgg gct tgg gaa acg ctc cga gac act gta gca cca gtt gta ccc       2012
Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val Ala Pro Val Val Pro           
            345                 350                 355                   

gat tta agt agt gac att gat act agt aat ttt gat gac ttg gaa gaa       2060
Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe Asp Asp Leu Glu Glu           
        360                 365                 370                       

gat aaa gga gag gaa gaa aca ttc cct att cct aaa gct ttc gtt ggc       2108
Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro Lys Ala Phe Val Gly           
    375                 380                 385                           

aat caa cta cct ttt gta gga ttt aca tat tat agc aat cgt aga tac       2156
Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr Ser Asn Arg Arg Tyr           
390                 395                 400                 405           

tta tct tca gca aat cct aat gat aac aga act agc tcc aat gca gat       2204
Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr Ser Ser Asn Ala Asp           
                410                 415                 420               

aaa agc ttg cag gaa agt ttg caa aaa aca atc tat aag ctg gaa gaa       2252
Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile Tyr Lys Leu Glu Glu           
            425                 430                 435                   

cag ctg cat aat gaa atg cag tta aaa gat gaa atg gag cag aag tgc       2300
Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu Met Glu Gln Lys Cys           
        440                 445                 450                       

aga acc tca aac ata aaa cta gac aag ata atg aaa gaa ttg gat gaa       2348
Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met Lys Glu Leu Asp Glu           
    455                 460                 465                           

gag gga aat caa aga aga aat cta gaa tct aca gtg tct cag att gag       2396
Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr Val Ser Gln Ile Glu           
470                 475                 480                 485           

aag gag aaa atg ttg cta cag cat aga att aat gag tac caa aga aaa       2444
Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn Glu Tyr Gln Arg Lys           
                490                 495                 500               

gct gaa cag gaa aat gag aag aga aga aat gta gaa aat gaa gtt tct       2492
Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val Glu Asn Glu Val Ser           
            505                 510                 515                   

aca tta aag gat cag ttg gaa gac tta aag aaa gtc agt cag aat tca       2540
Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys Val Ser Gln Asn Ser           
        520                 525                 530                       

cag ctt gct aat gag aag ctg tcc cag tta caa aag cag cta gaa gaa       2588
Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln Lys Gln Leu Glu Glu           
    535                 540                 545                           

gcc aat gac tta ctt agg aca gaa tcg gac aca gct gta aga ttg agg       2636
Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr Ala Val Arg Leu Arg           
550                 555                 560                 565           

aag agt cac aca gag atg agc aag tca att agt cag tta gag tcc ctg       2684
Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser Gln Leu Glu Ser Leu           
                570                 575                 580               

aac aga gag ttg caa gag aga aat cga att tta gag aat tct aag tca       2732
Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu Glu Asn Ser Lys Ser           
            585                 590                 595                   

caa aca gac aaa gat tat tac cag ctg caa gct ata tta gaa gct gaa       2780
Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala Ile Leu Glu Ala Glu           
        600                 605                 610                       

cga aga gac aga ggt cat gat tct gag atg att gga gac ctt caa gct       2828
Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile Gly Asp Leu Gln Ala           
    615                 620                 625                           

cga att aca tct tta caa gag gag gtg aag cat ctc aaa cat aat ctc       2876
Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His Leu Lys His Asn Leu           
630                 635                 640                 645           

gaa aaa gtg gaa gga gaa aga aaa gag gct caa gac atg ctt aat cac       2924
Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln Asp Met Leu Asn His           
                650                 655                 660               

tca gaa aag gaa aag aat aat tta gag ata gat tta aac tac aaa ctt       2972
Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp Leu Asn Tyr Lys Leu           
            665                 670                 675                   

aaa tca tta caa caa cgg tta gaa caa gag gta aat gaa cac aaa gta       3020
Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val Asn Glu His Lys Val           
        680                 685                 690                       

acc aaa gct cgt tta act gac aaa cat caa tct att gaa gag gca aag       3068
Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser Ile Glu Glu Ala Lys           
    695                 700                 705                           

tct gtg gca atg tgt gag atg gaa aaa aag ctg aaa gaa gaa aga gaa       3116
Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu Lys Glu Glu Arg Glu           
710                 715                 720                 725           

gct cga gag aag gct gaa aat cgg gtt gtt cag att gag aaa cag tgt       3164
Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln Ile Glu Lys Gln Cys           
                730                 735                 740               

tcc atg cta gac gtt gat ctg aag caa tct cag cag aaa cta gaa cat       3212
Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln Gln Lys Leu Glu His           
            745                 750                 755                   

ttg act gga aat aaa gaa agg atg gag gat gaa gtt aag aat cta acc       3260
Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu Val Lys Asn Leu Thr           
        760                 765                 770                       

ctg caa ctg gag cag gaa tca aat aag cgg ctg ttg tta caa aat gaa       3308
Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu Leu Leu Gln Asn Glu           
    775                 780                 785                           

ttg aag act caa gca ttt gag gca gac aat tta aaa ggt tta gaa aag       3356
Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu Lys Gly Leu Glu Lys           
790                 795                 800                 805           

cag atg aaa cag gaa ata aat act tta ttg gaa gca aag aga tta tta       3404
Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu Ala Lys Arg Leu Leu           
                810                 815                 820               

gaa ttt gag tta gct cag ctt acg aaa cag tat aga gga aat gaa gga       3452
Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr Arg Gly Asn Glu Gly           
            825                 830                 835                   

cag atg cgg gag cta caa gat cag ctt gaa gct gag caa tat ttc tcg       3500
Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala Glu Gln Tyr Phe Ser           
        840                 845                 850                       

aca ctt tat aaa acc cag gta aag gaa ctt aaa gaa gaa att gaa gaa       3548
Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys Glu Glu Ile Glu Glu           
    855                 860                 865                           

aaa aac aga gaa aat tta aag aaa ata cag gaa cta caa aat gaa aaa       3596
Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu Leu Gln Asn Glu Lys           
870                 875                 880                 885           

gaa act ctt gct act cag ttg gat cta gca gaa aca aaa gct gag tct       3644
Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu Thr Lys Ala Glu Ser           
                890                 895                 900               

gag cag ttg gcg cga ggc ctt ctg gaa gaa cag tat ttt gaa ttg acg       3692
Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln Tyr Phe Glu Leu Thr           
            905                 910                 915                   

caa gaa agc aag aaa gct gct tca aga aat aga caa gag att aca gat       3740
Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg Gln Glu Ile Thr Asp           
        920                 925                 930                       

aaa gat cac act gtt agt cgg ctt gaa gaa gca aac agc atg cta acc       3788
Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala Asn Ser Met Leu Thr           
    935                 940                 945                           

aaa gat att gaa ata tta aga aga gag aat gaa gag cta aca gag aaa       3836
Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu Glu Leu Thr Glu Lys           
950                 955                 960                 965           

atg aag aag gca gag gaa gaa tat aaa ctg gag aag gag gag gag atc       3884
Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu Lys Glu Glu Glu Ile           
                970                 975                 980               

agt aat ctt aag gct gcc ttt gaa aag aat atc aac act gaa cga acc       3932
Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile Asn Thr Glu Arg Thr           
            985                 990                 995                   

ctt aaa aca  cag gct gtt aac aaa  ttg gca gaa ata atg  aat cga        3977
Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu Ile Met  Asn Arg            
        1000                 1005                 1010                    

aaa gat ttt  aaa att gat aga aag  aaa gct aat aca caa  gat ttg        4022
Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn Thr Gln  Asp Leu            
        1015                 1020                 1025                    

aga aag aaa  gaa aag gaa aat cga  aag ctg caa ctg gaa  ctc aac        4067
Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln Leu Glu  Leu Asn            
        1030                 1035                 1040                    

caa gaa aga  gag aaa ttc aac cag  atg gta gtg aaa cat  cag aag        4112
Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val Lys His  Gln Lys            
        1045                 1050                 1055                    

gaa ctg aat  gac atg caa gcg caa  ttg gta gaa gaa tgt  gca cat        4157
Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu Glu Cys  Ala His            
        1060                 1065                 1070                    

agg aat gag  ctt cag atg cag ttg  gcc agc aaa gag agt  gat att        4202
Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys Glu Ser  Asp Ile            
        1075                 1080                 1085                    

gag caa ttg  cgt gct aaa ctt ttg  gac ctc tcg gat tct  aca agt        4247
Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser Asp Ser  Thr Ser            
        1090                 1095                 1100                    

gtt gct agt  ttt cct agt gct gat  gaa act gat ggt aac  ctc cca        4292
Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp Gly Asn  Leu Pro            
        1105                 1110                 1115                    

gag tca aga  att gaa ggt tgg ctt  tca gta cca aat aga  gga aat        4337
Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro Asn Arg  Gly Asn            
        1120                 1125                 1130                    

atc aaa cga  tat ggc tgg aag aaa  cag tat gtt gtg gta  agc agc        4382
Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val Val Val  Ser Ser            
        1135                 1140                 1145                    

aaa aaa att  ttg ttc tat aat gac  gaa caa gat aag gag  caa tcc        4427
Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp Lys Glu  Gln Ser            
        1150                 1155                 1160                    

aat cca tct  atg gta ttg gac ata  gat aaa ctg ttt cac  gtt aga        4472
Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu Phe His  Val Arg            
        1165                 1170                 1175                    

cct gta acc  caa gga gat gtg tat  aga gct gaa act gaa  gaa att        4517
Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu Thr Glu  Glu Ile            
        1180                 1185                 1190                    

cct aaa ata  ttc cag ata cta tat  gca aat gaa ggt gaa  tgt aga        4562
Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu Gly Glu  Cys Arg            
        1195                 1200                 1205                    

aaa gat gta  gag atg gaa cca gta  caa caa gct gaa aaa  act aat        4607
Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala Glu Lys  Thr Asn            
        1210                 1215                 1220                    

ttc caa aat  cac aaa ggc cat gag  ttt att cct aca ctc  tac cac        4652
Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro Thr Leu  Tyr His            
        1225                 1230                 1235                    

ttt cct gcc  aat tgt gat gcc tgt  gcc aaa cct ctc tgg  cat gtt        4697
Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro Leu Trp  His Val            
        1240                 1245                 1250                    

ttt aag cca  ccc cct gcc cta gag  tgt cga aga tgc cat  gtt aag        4742
Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg Cys His  Val Lys            
        1255                 1260                 1265                    

tgc cac aga  gat cac tta gat aag  aaa gag gac tta att  tgt cca        4787
Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp Leu Ile  Cys Pro            
        1270                 1275                 1280                    

tgt aaa gta  agt tat gat gta aca  tca gca aga gat atg  ctg ctg        4832
Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg Asp Met  Leu Leu            
        1285                 1290                 1295                    

tta gca tgt  tct cag gat gaa caa  aaa aaa tgg gta act  cat tta        4877
Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp Val Thr  His Leu            
        1300                 1305                 1310                    

gta aag aaa  atc cct aag aat cca  cca tct ggt ttt gtt  cgt gct        4922
Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly Phe Val  Arg Ala            
        1315                 1320                 1325                    

tcc cct cga  acg ctt tct aca aga  tcc act gca aat cag  tct ttc        4967
Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala Asn Gln  Ser Phe            
        1330                 1335                 1340                    

cgg aaa gtg  gtc aaa aat aca tct  gga aaa act agt taa ccatgtgact      5016
Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr Ser                         
        1345                 1350                                         

gagtgccctg tggaatcgtg tgggatgcta cctgataaac caggcttctt taaccatgca     5076

gagcagacag gctgtttctt tgacacaaat atcacaggct tcagggttaa gattgctgtt     5136

tttctgtcct tgctttggca caacacactg agggtttttt ttattgcggg tttgcctaca     5196

ggtagattag attaattatt actatgtaat gcaagtacag ttgggggaaa gcttaggtag     5256

atatattttt tttaaaaggt gctgcctttt tggatttata agaaaatgcc tgtcagtcgt     5316

gatagaacag agttttcctc atatgagtaa gaggaaggga ctttcacttt caagtggaac     5376

agccatcact atcaagatca gctcatggaa ggagtaaaga aaatatctca aaatgagaca     5436

aactgaagtt ttgttttttt tttaatgact taagtttttg tgctcttgca agactataca     5496

aaactatttt aagaaagcag tgatatcact tgaacttcag tgccctcact gtagaattta     5556

aaagccttac tgttgattgc ccatgttgga cttgatggag aaattaaata tctttcatta     5616

tgctttacaa aatactgtat atgtttcagc aagtttgggg aatgggagag gacaaaaaaa     5676

agttacattt aatctatgca tttttgccaa gccatattga gttattttac tactagagac     5736

attaggaaac taactgtaca aaagaaccaa gtttaaaagc attttgtggg gtacatcatt     5796

tctataattg tataatgtat ttctttgtgg ttttaaatga taaagacatt aagttaacaa     5856

acatataaga aatgtatgca ctgtttgaaa tgtaaattat tcttagaaca ctttcaatgg     5916

gggttgcatt gtccttttag tgccttaatt tgagataatt attttactgc catgagtaag     5976

tatagaaatt tcaaaaaatg tattttcaaa aaattatgtg tgtcagtgag tttttcattg     6036

ataattggtt taatttaaaa tatttagagg tttgttggac tttcataaat tgagtacaat     6096

ctttgcatca aactacctgc tacaataatg actttataaa actgcaaaaa atgtagaagg     6156

ttgcaccaac ataaaaagga aatatggcaa tacatccatg atgttttcca gttaacatag     6216

gaattaccag ataaatactg ttaaactctt gtccagtaac aagagttgat tcatatggac     6276

agtatgattt attgtttatt tttttaacca aatacctcct cagtaattta taatggcttt     6336

gcagtaatgt gtatcagata agaagcactg gaaaaccgat cgtctctagg atgatatgca     6396

tgtttcaagt ggtattgaaa gccgcactga tggatatgta ataataaaca tatctgttat     6456

taatatacta atgactctgt gctcatttaa tgagaaataa aagtaattta tggatgggta     6516

tctttaattt ttactgcaat gtgttttctc atggctgaaa tgaatggaaa acatacttca     6576

aattagtctc tgattgtata taaatgtttg tgaaattcca tggttagatt aaagtgtatt     6636

tttaaaagat aaaa                                                       6650


<210>  2
<211>  1354
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn 
1               5                   10                  15      


Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
            20                  25                  30          


Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
        35                  40                  45              


Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
    50                  55                  60                  


Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                85                  90                  95      


Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
            100                 105                 110         


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
        115                 120                 125             


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
145                 150                 155                 160 


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                165                 170                 175     


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
            180                 185                 190         


Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
        195                 200                 205             


Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
    210                 215                 220                 


Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
225                 230                 235                 240 


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                245                 250                 255     


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
            260                 265                 270         


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
        275                 280                 285             


Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
    290                 295                 300                 


Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
305                 310                 315                 320 


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                325                 330                 335     


Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
            340                 345                 350         


Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
        355                 360                 365             


Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro 
    370                 375                 380                 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr 
                405                 410                 415     


Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile 
            420                 425                 430         


Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
        435                 440                 445             


Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
    450                 455                 460                 


Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr 
465                 470                 475                 480 


Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                485                 490                 495     


Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
            500                 505                 510         


Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys 
        515                 520                 525             


Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
545                 550                 555                 560 


Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser 
                565                 570                 575     


Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu 
            580                 585                 590         


Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
        595                 600                 605             


Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
    610                 615                 620                 


Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
625                 630                 635                 640 


Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln 
                645                 650                 655     


Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
            660                 665                 670         


Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val 
        675                 680                 685             


Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
    690                 695                 700                 


Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
705                 710                 715                 720 


Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln 
                725                 730                 735     


Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
            740                 745                 750         


Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu 
        755                 760                 765             


Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu 
    770                 775                 780                 


Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
785                 790                 795                 800 


Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                805                 810                 815     


Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
            820                 825                 830         


Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
        835                 840                 845             


Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
    850                 855                 860                 


Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu 
865                 870                 875                 880 


Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu 
                885                 890                 895     


Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln 
            900                 905                 910         


Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
        915                 920                 925             


Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
    930                 935                 940                 


Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu 
945                 950                 955                 960 


Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu 
                965                 970                 975     


Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
            980                 985                 990         


Asn Thr Glu Arg Thr Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu 
        995                 1000                 1005             


Ile Met  Asn Arg Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn 
    1010                 1015                 1020             


Thr Gln  Asp Leu Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln 
    1025                 1030                 1035             


Leu Glu  Leu Asn Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val 
    1040                 1045                 1050             


Lys His  Gln Lys Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu 
    1055                 1060                 1065             


Glu Cys  Ala His Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys 
    1070                 1075                 1080             


Glu Ser  Asp Ile Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser 
    1085                 1090                 1095             


Asp Ser  Thr Ser Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp 
    1100                 1105                 1110             


Gly Asn  Leu Pro Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro 
    1115                 1120                 1125             


Asn Arg  Gly Asn Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val 
    1130                 1135                 1140             


Val Val  Ser Ser Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp 
    1145                 1150                 1155             


Lys Glu  Gln Ser Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu 
    1160                 1165                 1170             


Phe His  Val Arg Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Ile Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu 
    1190                 1195                 1200             


Gly Glu  Cys Arg Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala 
    1205                 1210                 1215             


Glu Lys  Thr Asn Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro 
    1220                 1225                 1230             


Thr Leu  Tyr His Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro 
    1235                 1240                 1245             


Leu Trp  His Val Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg 
    1250                 1255                 1260             


Cys His  Val Lys Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp 
    1265                 1270                 1275             


Leu Ile  Cys Pro Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg 
    1280                 1285                 1290             


Asp Met  Leu Leu Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp 
    1295                 1300                 1305             


Val Thr  His Leu Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly 
    1310                 1315                 1320             


Phe Val  Arg Ala Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala 
    1325                 1330                 1335             


Asn Gln  Ser Phe Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr 
    1340                 1345                 1350             


Ser 
    


<210>  3
<211>  6401
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (450)..(4616)

<400>  3
caaggcggcc ggcggcgacc atggcagcgg gccggcggcg gccgtagtgg cccaggcctg       60

ggcttcagcc tcccggggcc ccagagggcg gggcggtccg ggccgcggcg gtggcggcgc      120

cacttccctg ctcccgcccg aggactcctg cgggcactcg ctgaggacca gcggaccggc      180

ggcgcgaatc tgactgaggg gcggggacgc cgtctgttcc ccgccgctcc cggcagggcc      240

gggccgggct gggccgggct gggccgggcg ggcccctggg agcagccccc aggcggggga      300

ccgccttgga gacccgaagc cggagctaga ggcaggcggt gggcccgggt ggagtcccgg      360

ccggagctgg tggttcgggg gcggtgctag gccccgaggc tgcgggacct gagcgcgagg      420

agcctgagtg cgggtccagc ggtggcggc atg agc cgg ccc ccg ccg acg ggg        473
                                Met Ser Arg Pro Pro Pro Thr Gly           
                                1               5                         

aaa atg ccc ggc gcc ccc gag acc gcg ccg ggg gac ggg gca ggc gcg        521
Lys Met Pro Gly Ala Pro Glu Thr Ala Pro Gly Asp Gly Ala Gly Ala           
    10                  15                  20                            

agc cgc cag agg aag ctg gag gcg ctg atc cga gac cct cgc tcc ccc        569
Ser Arg Gln Arg Lys Leu Glu Ala Leu Ile Arg Asp Pro Arg Ser Pro           
25                  30                  35                  40            

atc aac gtg gag agc ttg ctg gat ggc tta aat tcc ttg gtc ctt gat        617
Ile Asn Val Glu Ser Leu Leu Asp Gly Leu Asn Ser Leu Val Leu Asp           
                45                  50                  55                

tta gat ttt cct gct ttg agg aaa aac aag aac ata gat aat ttc tta        665
Leu Asp Phe Pro Ala Leu Arg Lys Asn Lys Asn Ile Asp Asn Phe Leu           
            60                  65                  70                    

aat aga tat gag aaa att gtg aaa aaa atc aga ggt cta cag atg aag        713
Asn Arg Tyr Glu Lys Ile Val Lys Lys Ile Arg Gly Leu Gln Met Lys           
        75                  80                  85                        

gca gaa gac tat gat gtt gta aaa gtt att gga aga ggt gct ttt ggt        761
Ala Glu Asp Tyr Asp Val Val Lys Val Ile Gly Arg Gly Ala Phe Gly           
    90                  95                  100                           

gaa gtg cag ttg gtt cgt cac aag gca tcg cag aag gtt tat gct atg        809
Glu Val Gln Leu Val Arg His Lys Ala Ser Gln Lys Val Tyr Ala Met           
105                 110                 115                 120           

aag ctt ctt agt aag ttt gaa atg ata aaa aga tca gat tct gcc ttt        857
Lys Leu Leu Ser Lys Phe Glu Met Ile Lys Arg Ser Asp Ser Ala Phe           
                125                 130                 135               

ttt tgg gaa gaa aga gat att atg gcc ttt gcc aat agc ccc tgg gtg        905
Phe Trp Glu Glu Arg Asp Ile Met Ala Phe Ala Asn Ser Pro Trp Val           
            140                 145                 150                   

gtt cag ctt ttt tat gcc ttt caa gat gat agg tat ctg tac atg gta        953
Val Gln Leu Phe Tyr Ala Phe Gln Asp Asp Arg Tyr Leu Tyr Met Val           
        155                 160                 165                       

atg gag tac atg cct ggt gga gac ctt gta aac ctt atg agt aat tat       1001
Met Glu Tyr Met Pro Gly Gly Asp Leu Val Asn Leu Met Ser Asn Tyr           
    170                 175                 180                           

gat gtg cct gaa aaa tgg gcc aaa ttt tac act gct gaa gtt gtt ctt       1049
Asp Val Pro Glu Lys Trp Ala Lys Phe Tyr Thr Ala Glu Val Val Leu           
185                 190                 195                 200           

gct ctg gat gca ata cac tcc atg ggt tta ata cac aga gat gtg aag       1097
Ala Leu Asp Ala Ile His Ser Met Gly Leu Ile His Arg Asp Val Lys           
                205                 210                 215               

cct gac aac atg ctc ttg gat aaa cat gga cat cta aaa tta gca gat       1145
Pro Asp Asn Met Leu Leu Asp Lys His Gly His Leu Lys Leu Ala Asp           
            220                 225                 230                   

ttt ggc acg tgt atg aag atg gat gaa aca ggc atg gta cat tgt gat       1193
Phe Gly Thr Cys Met Lys Met Asp Glu Thr Gly Met Val His Cys Asp           
        235                 240                 245                       

aca gca gtt gga aca ccg gat tat ata tca cct gag gtt ctg aaa tca       1241
Thr Ala Val Gly Thr Pro Asp Tyr Ile Ser Pro Glu Val Leu Lys Ser           
    250                 255                 260                           

caa ggg ggt gat ggt ttc tat ggg cga gaa tgt gat tgg tgg tct gta       1289
Gln Gly Gly Asp Gly Phe Tyr Gly Arg Glu Cys Asp Trp Trp Ser Val           
265                 270                 275                 280           

ggt gtt ttc ctt tat gag atg cta gtg ggg gat act cca ttt tat gcg       1337
Gly Val Phe Leu Tyr Glu Met Leu Val Gly Asp Thr Pro Phe Tyr Ala           
                285                 290                 295               

gat tca ctt gta gga aca tat agc aaa att atg gat cat aag aat tca       1385
Asp Ser Leu Val Gly Thr Tyr Ser Lys Ile Met Asp His Lys Asn Ser           
            300                 305                 310                   

ctg tgt ttc cct gaa gat gca gaa att tcc aaa cat gca aag aat ctc       1433
Leu Cys Phe Pro Glu Asp Ala Glu Ile Ser Lys His Ala Lys Asn Leu           
        315                 320                 325                       

atc tgt gct ttc tta aca gat agg gag gta cga ctt ggg aga aat ggg       1481
Ile Cys Ala Phe Leu Thr Asp Arg Glu Val Arg Leu Gly Arg Asn Gly           
    330                 335                 340                           

gtg gaa gaa atc aga cag cat cct ttc ttt aag aat gat cag tgg cat       1529
Val Glu Glu Ile Arg Gln His Pro Phe Phe Lys Asn Asp Gln Trp His           
345                 350                 355                 360           

tgg gat aac ata aga gaa acg gca gct cct gta gta cct gaa ctc agc       1577
Trp Asp Asn Ile Arg Glu Thr Ala Ala Pro Val Val Pro Glu Leu Ser           
                365                 370                 375               

agt gac ata gac agc agc aat ttc gat gac att gaa gat gac aaa gga       1625
Ser Asp Ile Asp Ser Ser Asn Phe Asp Asp Ile Glu Asp Asp Lys Gly           
            380                 385                 390                   

gat gta gaa acc ttc cca att cct aaa gct ttt gtt gga aat cag ctg       1673
Asp Val Glu Thr Phe Pro Ile Pro Lys Ala Phe Val Gly Asn Gln Leu           
        395                 400                 405                       

cct ttc atc gga ttt acc tac tat aga gaa aat tta tta tta agt gac       1721
Pro Phe Ile Gly Phe Thr Tyr Tyr Arg Glu Asn Leu Leu Leu Ser Asp           
    410                 415                 420                           

tct cca tct tgt aga gaa act gat tcc ata caa tca agg aaa aat gaa       1769
Ser Pro Ser Cys Arg Glu Thr Asp Ser Ile Gln Ser Arg Lys Asn Glu           
425                 430                 435                 440           

gaa agt caa gag att cag aaa aaa ctg tat aca tta gaa gaa cat ctt       1817
Glu Ser Gln Glu Ile Gln Lys Lys Leu Tyr Thr Leu Glu Glu His Leu           
                445                 450                 455               

agc aat gag atg caa gcc aaa gag gaa ctg gaa cag aag tgc aaa tct       1865
Ser Asn Glu Met Gln Ala Lys Glu Glu Leu Glu Gln Lys Cys Lys Ser           
            460                 465                 470                   

gtt aat act cgc cta gaa aaa aca gca aag gag cta gaa gag gag att       1913
Val Asn Thr Arg Leu Glu Lys Thr Ala Lys Glu Leu Glu Glu Glu Ile           
        475                 480                 485                       

acc tta cgg aaa agt gtg gaa tca gca tta aga cag tta gaa aga gaa       1961
Thr Leu Arg Lys Ser Val Glu Ser Ala Leu Arg Gln Leu Glu Arg Glu           
    490                 495                 500                           

aag gcg ctt ctt cag cac aaa aat gca gaa tat cag agg aaa gct gat       2009
Lys Ala Leu Leu Gln His Lys Asn Ala Glu Tyr Gln Arg Lys Ala Asp           
505                 510                 515                 520           

cat gaa gca gac aaa aaa cga aat ttg gaa aat gat gtt aac agc tta       2057
His Glu Ala Asp Lys Lys Arg Asn Leu Glu Asn Asp Val Asn Ser Leu           
                525                 530                 535               

aaa gat caa ctt gaa gat ttg aaa aaa aga aat caa aac tct caa ata       2105
Lys Asp Gln Leu Glu Asp Leu Lys Lys Arg Asn Gln Asn Ser Gln Ile           
            540                 545                 550                   

tcc act gag aaa gtg aat caa ctc cag aga caa ctg gat gaa acc aat       2153
Ser Thr Glu Lys Val Asn Gln Leu Gln Arg Gln Leu Asp Glu Thr Asn           
        555                 560                 565                       

gct tta ctg cga aca gag tct gat act gca gcc cgg tta agg aaa acc       2201
Ala Leu Leu Arg Thr Glu Ser Asp Thr Ala Ala Arg Leu Arg Lys Thr           
    570                 575                 580                           

cag gca gaa agt tca aaa cag att cag cag ctg gaa tct aac aat aga       2249
Gln Ala Glu Ser Ser Lys Gln Ile Gln Gln Leu Glu Ser Asn Asn Arg           
585                 590                 595                 600           

gat cta caa gat aaa aac tgc ctg ctg gag act gcc aag tta aaa ctt       2297
Asp Leu Gln Asp Lys Asn Cys Leu Leu Glu Thr Ala Lys Leu Lys Leu           
                605                 610                 615               

gaa aag gaa ttt atc aat ctt cag tca gct cta gaa tct gaa agg agg       2345
Glu Lys Glu Phe Ile Asn Leu Gln Ser Ala Leu Glu Ser Glu Arg Arg           
            620                 625                 630                   

gat cga acc cat gga tca gag ata att aat gat tta caa ggt aga ata       2393
Asp Arg Thr His Gly Ser Glu Ile Ile Asn Asp Leu Gln Gly Arg Ile           
        635                 640                 645                       

tgt ggc cta gaa gaa gat tta aag aac ggc aaa atc tta cta gcg aaa       2441
Cys Gly Leu Glu Glu Asp Leu Lys Asn Gly Lys Ile Leu Leu Ala Lys           
    650                 655                 660                           

gta gaa ctg gag aag aga caa ctt cag gag aga ttt act gat ttg gaa       2489
Val Glu Leu Glu Lys Arg Gln Leu Gln Glu Arg Phe Thr Asp Leu Glu           
665                 670                 675                 680           

aag gaa aaa agc aac atg gaa ata gat atg aca tac caa cta aaa gtt       2537
Lys Glu Lys Ser Asn Met Glu Ile Asp Met Thr Tyr Gln Leu Lys Val           
                685                 690                 695               

ata cag cag agc cta gaa caa gaa gaa gct gaa cat aag gcc aca aag       2585
Ile Gln Gln Ser Leu Glu Gln Glu Glu Ala Glu His Lys Ala Thr Lys           
            700                 705                 710                   

gca cga cta gca gat aaa aat aag atc tat gag tcc atc gaa gaa gcc       2633
Ala Arg Leu Ala Asp Lys Asn Lys Ile Tyr Glu Ser Ile Glu Glu Ala           
        715                 720                 725                       

aaa tca gaa gcc atg aaa gaa atg gag aag aag ctc ttg gag gaa aga       2681
Lys Ser Glu Ala Met Lys Glu Met Glu Lys Lys Leu Leu Glu Glu Arg           
    730                 735                 740                           

act tta aaa cag aaa gtg gag aac cta ttg cta gaa gct gag aaa aga       2729
Thr Leu Lys Gln Lys Val Glu Asn Leu Leu Leu Glu Ala Glu Lys Arg           
745                 750                 755                 760           

tgt tct cta tta gac tgt gac ctc aaa cag tca cag cag aaa ata aat       2777
Cys Ser Leu Leu Asp Cys Asp Leu Lys Gln Ser Gln Gln Lys Ile Asn           
                765                 770                 775               

gag ctc ctt aaa cag aaa gat gtg cta aat gag gat gtt aga aac ctg       2825
Glu Leu Leu Lys Gln Lys Asp Val Leu Asn Glu Asp Val Arg Asn Leu           
            780                 785                 790                   

aca tta aaa ata gag caa gaa act cag aag cgc tgc ctt aca caa aat       2873
Thr Leu Lys Ile Glu Gln Glu Thr Gln Lys Arg Cys Leu Thr Gln Asn           
        795                 800                 805                       

gac ctg aag atg caa aca caa cag gtt aac aca cta aaa atg tca gaa       2921
Asp Leu Lys Met Gln Thr Gln Gln Val Asn Thr Leu Lys Met Ser Glu           
    810                 815                 820                           

aag cag tta aag caa gaa aat aac cat ctc atg gaa atg aaa atg aac       2969
Lys Gln Leu Lys Gln Glu Asn Asn His Leu Met Glu Met Lys Met Asn           
825                 830                 835                 840           

ttg gaa aaa caa aat gct gaa ctt cga aaa gaa cgt cag gat gca gat       3017
Leu Glu Lys Gln Asn Ala Glu Leu Arg Lys Glu Arg Gln Asp Ala Asp           
                845                 850                 855               

ggg caa atg aaa gag ctc cag gat cag ctc gaa gca gaa cag tat ttc       3065
Gly Gln Met Lys Glu Leu Gln Asp Gln Leu Glu Ala Glu Gln Tyr Phe           
            860                 865                 870                   

tca acc ctt tat aaa aca caa gtt agg gag ctt aaa gaa gaa tgt gaa       3113
Ser Thr Leu Tyr Lys Thr Gln Val Arg Glu Leu Lys Glu Glu Cys Glu           
        875                 880                 885                       

gaa aag acc aaa ctt ggt aaa gaa ttg cag cag aag aaa cag gaa tta       3161
Glu Lys Thr Lys Leu Gly Lys Glu Leu Gln Gln Lys Lys Gln Glu Leu           
    890                 895                 900                           

cag gat gaa cgg gac tct ttg gct gcc caa ctg gag atc acc ttg acc       3209
Gln Asp Glu Arg Asp Ser Leu Ala Ala Gln Leu Glu Ile Thr Leu Thr           
905                 910                 915                 920           

aaa gca gat tct gag caa ctg gct cgt tca att gct gaa gaa caa tat       3257
Lys Ala Asp Ser Glu Gln Leu Ala Arg Ser Ile Ala Glu Glu Gln Tyr           
                925                 930                 935               

tct gat ttg gaa aaa gag aag atc atg aaa gag ctg gag atc aaa gag       3305
Ser Asp Leu Glu Lys Glu Lys Ile Met Lys Glu Leu Glu Ile Lys Glu           
            940                 945                 950                   

atg atg gct aga cac aaa cag gaa ctt acg gaa aaa gat gct aca att       3353
Met Met Ala Arg His Lys Gln Glu Leu Thr Glu Lys Asp Ala Thr Ile           
        955                 960                 965                       

gct tct ctt gag gaa act aat agg aca cta act agt gat gtt gcc aat       3401
Ala Ser Leu Glu Glu Thr Asn Arg Thr Leu Thr Ser Asp Val Ala Asn           
    970                 975                 980                           

ctt gca aat gag aaa gaa gaa tta aat aac aaa ttg aaa gat gtt caa       3449
Leu Ala Asn Glu Lys Glu Glu Leu Asn Asn Lys Leu Lys Asp Val Gln           
985                 990                 995                 1000          

gag caa ctg tca aga  ttg aaa gat gaa gaa  ata agc gca gca gct         3494
Glu Gln Leu Ser Arg  Leu Lys Asp Glu Glu  Ile Ser Ala Ala Ala             
                1005                 1010                 1015            

att aaa gca cag ttt  gag aag cag cta tta  aca gaa aga aca ctc         3539
Ile Lys Ala Gln Phe  Glu Lys Gln Leu Leu  Thr Glu Arg Thr Leu             
                1020                 1025                 1030            

aaa act caa gct gtg  aat aag ttg gct gag  atc atg aat cga aaa         3584
Lys Thr Gln Ala Val  Asn Lys Leu Ala Glu  Ile Met Asn Arg Lys             
                1035                 1040                 1045            

gaa cct gtc aag cgt  ggt aat gac aca gat  gtg cgg aga aaa gag         3629
Glu Pro Val Lys Arg  Gly Asn Asp Thr Asp  Val Arg Arg Lys Glu             
                1050                 1055                 1060            

aag gag aat aga aag  cta cat atg gag ctt  aaa tct gaa cgt gag         3674
Lys Glu Asn Arg Lys  Leu His Met Glu Leu  Lys Ser Glu Arg Glu             
                1065                 1070                 1075            

aaa ttg acc cag cag  atg atc aag tat cag  aaa gaa ctg aat gaa         3719
Lys Leu Thr Gln Gln  Met Ile Lys Tyr Gln  Lys Glu Leu Asn Glu             
                1080                 1085                 1090            

atg cag gca caa ata  gct gaa gag agc cag  att cga att gaa ctg         3764
Met Gln Ala Gln Ile  Ala Glu Glu Ser Gln  Ile Arg Ile Glu Leu             
                1095                 1100                 1105            

cag atg aca ttg gac  agt aaa gac agt gac  att gag cag ctg cgg         3809
Gln Met Thr Leu Asp  Ser Lys Asp Ser Asp  Ile Glu Gln Leu Arg             
                1110                 1115                 1120            

tca caa ctc caa gcc  ttg cat att ggt ctg  gat agt tcc agt ata         3854
Ser Gln Leu Gln Ala  Leu His Ile Gly Leu  Asp Ser Ser Ser Ile             
                1125                 1130                 1135            

ggc agt gga cca ggg  gat gct gag gca gat  gat ggg ttt cca gaa         3899
Gly Ser Gly Pro Gly  Asp Ala Glu Ala Asp  Asp Gly Phe Pro Glu             
                1140                 1145                 1150            

tca aga tta gaa gga  tgg ctt tca ttg cct  gta cga aac aac act         3944
Ser Arg Leu Glu Gly  Trp Leu Ser Leu Pro  Val Arg Asn Asn Thr             
                1155                 1160                 1165            

aag aaa ttt gga tgg  gtt aaa aag tat gtg  att gta agc agt aag         3989
Lys Lys Phe Gly Trp  Val Lys Lys Tyr Val  Ile Val Ser Ser Lys             
                1170                 1175                 1180            

aag att ctt ttc tat  gac agt gaa caa gat  aaa gaa caa tcc aat         4034
Lys Ile Leu Phe Tyr  Asp Ser Glu Gln Asp  Lys Glu Gln Ser Asn             
                1185                 1190                 1195            

cct tac atg gtt tta  gat ata gac aag tta  ttt cat gtc cga cca         4079
Pro Tyr Met Val Leu  Asp Ile Asp Lys Leu  Phe His Val Arg Pro             
                1200                 1205                 1210            

gtt aca cag aca gat  gtg tat aga gca gat  gct aaa gaa att cca         4124
Val Thr Gln Thr Asp  Val Tyr Arg Ala Asp  Ala Lys Glu Ile Pro             
                1215                 1220                 1225            

agg ata ttc cag att  ctg tat gcc aat gaa  gga gaa agt aag aag         4169
Arg Ile Phe Gln Ile  Leu Tyr Ala Asn Glu  Gly Glu Ser Lys Lys             
                1230                 1235                 1240            

gaa caa gaa ttt cca  gtg gag cca gtt gga  gaa aaa tct aat tat         4214
Glu Gln Glu Phe Pro  Val Glu Pro Val Gly  Glu Lys Ser Asn Tyr             
                1245                 1250                 1255            

att tgc cac aag gga  cat gag ttt att cct  act ctt tat cat ttc         4259
Ile Cys His Lys Gly  His Glu Phe Ile Pro  Thr Leu Tyr His Phe             
                1260                 1265                 1270            

cca acc aac tgt gag  gct tgt atg aag ccc  ctg tgg cac atg ttt         4304
Pro Thr Asn Cys Glu  Ala Cys Met Lys Pro  Leu Trp His Met Phe             
                1275                 1280                 1285            

aag cct cct cct gct  ttg gag tgc cgc cgt  tgc cat att aag tgt         4349
Lys Pro Pro Pro Ala  Leu Glu Cys Arg Arg  Cys His Ile Lys Cys             
                1290                 1295                 1300            

cat aaa gat cat atg  gac aaa aag gag gag  att ata gca cct tgc         4394
His Lys Asp His Met  Asp Lys Lys Glu Glu  Ile Ile Ala Pro Cys             
                1305                 1310                 1315            

aaa gta tat tat gat  att tca acg gca aag  aat ctg tta tta cta         4439
Lys Val Tyr Tyr Asp  Ile Ser Thr Ala Lys  Asn Leu Leu Leu Leu             
                1320                 1325                 1330            

gca aat tct aca gaa  gag cag cag aag tgg  gtt agt cgg ttg gtg         4484
Ala Asn Ser Thr Glu  Glu Gln Gln Lys Trp  Val Ser Arg Leu Val             
                1335                 1340                 1345            

aaa aag ata cct aaa  aag ccc cca gct cca  gac cct ttt gcc cga         4529
Lys Lys Ile Pro Lys  Lys Pro Pro Ala Pro  Asp Pro Phe Ala Arg             
                1350                 1355                 1360            

tca tct cct aga act  tca atg aag ata cag  caa aac cag tct att         4574
Ser Ser Pro Arg Thr  Ser Met Lys Ile Gln  Gln Asn Gln Ser Ile             
                1365                 1370                 1375            

aga cgg cca agt cga  cag ctt gcc cca aac  aaa cct agc taa             4616
Arg Arg Pro Ser Arg  Gln Leu Ala Pro Asn  Lys Pro Ser                     
                1380                 1385                                 

ctgccttcta tgaaagcagt cattattcaa ggtgatcgta ttcttccagt gaaaacaaga     4676

ctgaaatatg atggcccaaa atttattaaa aagctatatt ttcctgagag actgatacat     4736

acactcatac atatatgtgt tccccttttc cctgtaatat aaattacaaa tctgggctcc     4796

tttgaagcaa caggttgaac caacaatgat tggttgatag actaaggata tatgcaactc     4856

ttccagactt ttccataaag ctctctcggc agtcgctcac actacaatgc acacaaggat     4916

tgagaagagt taaaggctaa agaaaacatc ttttctagct tcaacagaga ggtttcacca     4976

gcacatttac cagaagaatc tgggaatgga ttccactaca gtgatattga ctgcatcttt     5036

aagaagtgac cattatactg tgtatatata tataaacaca cacacatata tatatatata     5096

tatagtactc taatactgca agaaggtttt ttaaacttcc cactttattt tttatacaca     5156

ttaatcagat atcattactt gctgcagttg caactatgca cttgtataaa gccataatgt     5216

tggagtttat atcactcatt cctgtgtacc tgatggaagt tgcatgttca tgtttaagca     5276

gttactgtaa caagaagttt aaagttaatt atatcagttt cctaatgctt catgataggc     5336

aactttaccc attttgaatg ccttaattta atttttttca aagtctcagc cctgtctgta     5396

ttaaaaaaca aaaaaagcgt ttaccagctc ttaggatgta aactagcttt gtggaagata     5456

aatcgtgcac tatttttaca cataaatagt tatatcaatg tcagcctatt ttgattaaca     5516

aatgttttta aagtattatt ggttatagaa acaataatgg atggtgttgg aactaatata     5576

tccttgatgt ctgtctatta ttcattcaac tctttttaca gacctcagta ttagtctgtg     5636

actacaaaat attttatttg ctttaaattt gctggctacc ctagatgtgt ttttattcct     5696

ggtaaagaca tttgtgatta cattttcaca cttaagattc aaaatttttc ccaaatataa     5756

agaaaactaa gacagactgt agatgcattt taaatattta aatatgatcc tcagacatgc     5816

agctgtgtgt ggcagtattt tagtaccggg ttaagaaaac tggcaactgg gaagaagtgg     5876

cctcaaaggc acttaatttg atttttattt tttaaatgct gtcaaagtta cagtttacgc     5936

aggacattct tgccgtattc tcatgatccc agataagtgt gtgttttata ctgcaacaat     5996

atgcagcaat ggtaagcgta aagttttttt tttgtttttg ttttttttta tattatgaag     6056

tcttttaaca gtctctcttt atataaatac acagagtttg gtatgatatt taaatacatc     6116

atctggccag gcatggtggc ttacgcctgt aatcctagca ctttgggagg ccaagacggg     6176

cggatcacct gaggtgagga gttcaagacc agcctgccca acatagtgaa actccgtctc     6236

taccaatata caaaaattag ccgggcatga tggtggtggc ctgtaatccc agctacttgg     6296

gaggctgaga caggagaatc gcttgaaccc aggagacggt ggttgcagtg agcgaagatc     6356

gagccactgc actccagcct gggcagctga acaagactcc gtctc                     6401


<210>  4
<211>  1388
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210>  5
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
cggtttgttt gggtttgggt ttgggtttgg gtttgggtt                              39


<210>  6
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
ggcttgcctt acccttaccc ttacccttac ccttaccct                              39


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
tgtgctggcc catcactttg                                                   20


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
accagccacc actttctgat agg                                               23


