                         SEQUENCE LISTING

<110>  F. Hoffmann - La Roche AG
 
<120>  Prediction of Genotoxicity

<130>  24699WO1

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  2328
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, t or u

<400>  1
rgngcgggaa gcaggggcgg ggcctctggt ggcggtcggg aactcggtgg gaggcggcaa       60

cattgtttca agttggccaa attgacaaga gcgagaggta tactgcgttc catcccgacc      120

cggggccacg gtactgggcc ctgtttcccc ctcctcggcc cccgagagcc agggtccgcc      180

ttctgcaggg ttcccaggcc cccgctccag ggccgggctg acccgactcg ctggcgcttc      240

atggagaact tccaaaaggt ggaaaagatc ggagagggca cgtacggagt tgtgtacaaa      300

gccagaaaca agttgacggg agaggtggtg gcgcttaaga aaatccgcct ggacactgag      360

actgagggtg tgcccagtac tgccatccga gagatctctc tgcttaagga gcttaaccat      420

cctaatattg tcaagctgct ggatgtcatt cacacagaaa ataaactcta cctggttttt      480

gaatttctgc accaagatct caagaaattc atggatgcct ctgctctcac tggcattcct      540

cttcccctca tcaagagcta tctgttccag ctgctccagg gcctagcttt ctgccattct      600

catcgggtcc tccaccgaga ccttaaacct cagaatctgc ttattaacac agagggggcc      660

atcaagctag cagactttgg actagccaga gcttttggag tccctgttcg tacttacacc      720

catgaggtgg tgaccctgtg gtaccgagct cctgaaatcc tcctgggctg caaatattat      780

tccacagctg tggacatctg gagcctgggc tgcatctttg ctgagatggt gactcgccgg      840

gccctattcc ctggagattc tgagattgac cagctcttcc ggatctttcg gactctgggg      900

accccagatg aggtggtgtg gccaggagtt acttctatgc ctgattacaa gccaagtttc      960

cccaagtggg cccggcaaga ttttagtaaa gttgtacctc ccctggatga agatggacgg     1020

agcttgttat cgcaaatgct gcactacgac cctaacaagc ggatttcggc caaggcagcc     1080

ctggctcacc ctttcttcca ggatgtgacc aagccagtac cccatcttcg actctgatag     1140

ccttcttgaa gcccccagcc ctaatctcac cctctcctcc agtgtgggct tgaccaggct     1200

tggccttggg ctatttggac tcaggtgggc cctctgaact tgccttaaac actcaccttc     1260

tagtcttggc cagccaactc tgggaataca ggggtgaaag gggggaacca gtgaaaatga     1320

aaggaagttt cagtattaga tgcacttaag ttagcctcca ccaccctttc ccccttctct     1380

tagttattgc tgaagagggt tggtataaaa ataattttaa aaaagccttc ctacacgtta     1440

gatttgccgt accaatctct gaatgcccca taattattat ttccagtgtt tgggatgacc     1500

aggatcccaa gcctcctgct gccacaatgt ttataaaggc caaatgatag cgggggctaa     1560

gttggtgctt ttgagaacca agtaaaacaa aaccactggg aggagtctat tttaaagaat     1620

tcggttgaaa aaatagatcc aatcagttta taccctagtt agtgttttgc ctcacctaat     1680

aggctgggag actgaagact cagcccgggt ggggctgcag aaaaatgatt ggccccagtc     1740

cccttgtttg tcccttctac aggcatgagg aatctgggag gccctgagac agggattgtg     1800

cttcattcca atctattgct tcaccatggc cttatgaggc aggtgagaga tgtttgaatt     1860

tttctcttcc ttttagtatt cttagttgtt cagttgccaa ggatccctga tcccattttc     1920

ctctgacgtc cacctcctac cccataggag ttagaagtta gggtttaggc atcattttga     1980

gaatgctgac actttttcag ggctgtgatt gagtgagggc atgggtaaaa atatttcttt     2040

aaaagaagga tgaacaatta tatttatatt tcaggttata tccaatagta gagttggctt     2100

tttttttttt tttttggtca tagtgggtgg atttgttgcc atgtgcacct tggggttttg     2160

taatgacagt gctaaaaaaa aaaagcattt tttttttatg atttgtctct gtcacccttg     2220

tccttgagtg ctcttgctat taacgttatt tgtaatttag tttgtagctc attaaaaaaa     2280

tgtgcctagt tttataaaaa aaaaaaaaaa aaacaaaaaa aaaaaaaa                  2328


<210>  2
<211>  1339
<212>  DNA
<213>  Homo sapiens

<400>  2
ggcgagacga gccgacgcag cagcgcagcc cagggggcgc gacgcagcag cgcggacccg       60

gagcgacaag cgccccgacg gagcgccagg acgagagaca ccaaagagaa cacgccgagg      120

gagacaagga gggaaggaaa aggaggagca gcagcagcaa aaagaaggaa gagacacaag      180

caggcccagg agaacaagcg cgcaaaacaa caccaaaagg gaagccaagg aaagcaggca      240

aaagagaaag aacaagcgac gcacagagag acagaaagac acaccaagga ggaaccggac      300

acgccaaaga gaccagaaag ccggacagaa ccaagagcaa gccggagaag ggaagaagag      360

aaaaagcaaa cacaggacac cacagaccac acgcgcacag ggaagagcac cgaaggaaaa      420

gaaccaggag gagaggagag aggagggcac cgacgcagag ggagacgaca aggcaagaag      480

aaaggaacag ggaaggagcg gaaaagggga ggcacgacaa aagcgggagg agacagagca      540

gaaaaaagaa aaagggaaga acggaagcgc cgccagaaaa caagcggaac acgaaacaac      600

agaccccaac agacccgcgg ccagagggaa gggagcacag gcacagcagg aacagggaca      660

gacacgacca aaagaaaagg caccacgacg gacaacagaa agaggcaaca gaagcaagcg      720

gaagcacaga aaaggaccac acagacaaag ccgaaaacac aggcagcgac acacagaggc      780

gaaacccaaa aaaaacggag aacgcaccaa aaaccagaaa aaggagacgg aggcaacaag      840

agacgaacac acagacagga cacaagacaa agagcaccga agaagcccag ggggcccaac      900

caggagcgga gcaaggagca cagaaacacg ggaccgacca acacacgaag aaggagcaag      960

caagaggaaa ggacggaccc accaaaacaa gaacagaaaa ccaggaaacg aaaacaccac     1020

gacgaagacg ggagaacaca gcgccggcag aagcaagacg cgaaacccga aggaaagccc     1080

aagaggaaca gagcgccgac ccacagaaaa gggagagacc agccaaaaga aacccagaga     1140

agccaaagca cccgacccga agaaaagaaa gacgaaggac agccccgaag agacacagac     1200

gacagcaaaa aaagagacag cgaaacaaca aagccagagg ggaaggcaaa gacaagcaag     1260

gaagaacacc agaagaaagg aacagaaaaa ggcagaagga agacgaacag gcaagaccac     1320

ccaccaaaag aaggacaag                                                  1339


<210>  3
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro 
1               5                   10                  15      


Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg 
            20                  25                  30          


Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu 
        35                  40                  45              


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
    50                  55                  60                  


Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser 
65                  70                  75                  80  


Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn 
                85                  90                  95      


His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu 
            100                 105                 110         


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
        115                 120                 125             


Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn 
    130                 135                 140                 


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu 
145                 150                 155                 160 


Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
                165                 170                 175     


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu 
            180                 185                 190         


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly 
        195                 200                 205             


Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala 
    210                 215                 220                 


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
225                 230                 235                 240 


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
                245                 250                 255     


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
            260                 265                 270         


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr 
        275                 280                 285             


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
    290                 295                 300                 


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp 
305                 310                 315                 320 


Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met 
                325                 330                 335     


Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly 
            340                 345                 350         


Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Tyr Gln 
        355                 360                 365             


Gly Pro Gly Thr Arg Arg Leu Gln Glu Val Leu Gly Val Gln Thr Gly 
    370                 375                 380                 


Gly Pro Gly Gly Arg Arg Ala Gly Glu Pro Gly His Ser Pro Ala Asp 
385                 390                 395                 400 


Tyr Leu Arg Phe Gln Asp Leu Val Leu Arg Met Leu Glu Tyr Glu Pro 
                405                 410                 415     


Ala Ala Arg Ile Ser Pro Leu Gly Ala Leu Gln His Gly Phe Phe Arg 
            420                 425                 430         


Arg Thr Ala Asp Glu Ala Thr Asn Thr Gly Pro Ala Gly Ser Ser Ala 
        435                 440                 445             


Ser Thr Ser Pro Ala Pro Leu Asp Thr Cys Pro Ser Ser Ser Thr Ala 
    450                 455                 460                 


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ser Gly Ser Ser Ser Asp Asn 
465                 470                 475                 480 


Arg Thr Tyr Arg Tyr Ser Asn Arg Tyr Cys Gly Gly Pro Gly Pro Pro 
                485                 490                 495     


Ile Thr Asp Cys Glu Met Asn Ser Pro Gln Val Pro Pro Ser Gln Pro 
            500                 505                 510         


Leu Arg Pro Trp Ala Gly Gly Asp Val Pro His Lys Thr His Gln Ala 
        515                 520                 525             


Pro Ala Ser Ala Ser Ser Leu Pro Gly Thr Gly Ala Gln Leu Pro Pro 
    530                 535                 540                 


Gln Pro Arg Tyr Leu Gly Arg Pro Pro Ser Pro Thr Ser Pro Pro Pro 
545                 550                 555                 560 


Pro Glu Leu Met Asp Val Ser Leu Val Gly Gly Pro Ala Asp Cys Ser 
                565                 570                 575     


Pro Pro His Pro Ala Pro Ala Pro Gln His Pro Ala Ala Ser Ala Leu 
            580                 585                 590         


Arg Thr Arg Met Thr Gly Gly Arg Pro Pro Leu Pro Pro Pro Asp Asp 
        595                 600                 605             


Pro Ala Thr Leu Gly Pro His Leu Gly Leu Arg Gly Val Pro Gln Ser 
    610                 615                 620                 


Thr Ala Ala Ser Ser 
625                 


<210>  4
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Cys Thr Val Val Asp Pro Arg Ile Val Arg Arg Tyr Leu Leu Arg 
1               5                   10                  15      


Arg Gln Leu Gly Gln Gly Ala Tyr Gly Ile Val Trp Lys Ala Val Asp 
            20                  25                  30          


Arg Arg Thr Gly Glu Val Val Ala Ile Lys Lys Ile Phe Asp Ala Phe 
        35                  40                  45              


Arg Asp Lys Thr Asp Ala Gln Arg Thr Phe Arg Glu Ile Thr Leu Leu 
    50                  55                  60                  


Gln Glu Phe Gly Asp His Pro Asn Ile Ile Ser Leu Leu Asp Val Ile 
65                  70                  75                  80  


Arg Ala Glu Asn Asp Arg Asp Ile Tyr Leu Val Phe Glu Phe Met Asp 
                85                  90                  95      


Thr Asp Leu Asn Ala Val Ile Arg Lys Gly Gly Leu Leu Gln Asp Val 
            100                 105                 110         


His Val Arg Ser Ile Phe Tyr Gln Leu Leu Arg Ala Thr Arg Phe Leu 
        115                 120                 125             


His Ser Gly His Val Val His Arg Asp Gln Lys Pro Ser Asn Val Leu 
    130                 135                 140                 


Leu Asp Ala Asn Cys Thr Val Lys Leu Cys Asp Phe Gly Leu Ala Arg 
145                 150                 155                 160 


Ser Leu Gly Asp Leu Pro Glu Gly Pro Glu Asp Gln Ala Val Thr Glu 
                165                 170                 175     


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Ser Ser 
            180                 185                 190         


His Arg Tyr Thr Leu Gly Val Asp Met Trp Ser Leu Gly Cys Ile Leu 
        195                 200                 205             


Gly Glu Met Leu Arg Gly Arg Pro Leu Phe Pro Gly Thr Ser Thr Leu 
    210                 215                 220                 


His Gln Leu Glu Leu Ile Leu Glu Thr Ile Pro Pro Pro Ser Glu Glu 
225                 230                 235                 240 


Asp Leu Leu Ala Leu Gly Ser Gly Cys Arg Ala Ser Val Leu His Gln 
                245                 250                 255     


Leu Gly Ser Arg Pro Arg Gln Thr Leu Asp Ala Leu Leu Pro Pro Asp 
            260                 265                 270         


Thr Ser Pro Glu Ala Leu Asp Leu Leu Arg Arg Leu Leu Val Phe Ala 
        275                 280                 285             


Pro Asp Lys Arg Leu Ser Ala Thr Gln Ala Leu Gln His Pro Tyr Val 
    290                 295                 300                 


Gln Arg Phe His Cys Pro Ser Asp Glu Trp Ala Arg Glu Ala Asp Val 
305                 310                 315                 320 


Arg Pro Arg Ala His Glu Gly Val Gln Leu Ser Val Pro Glu Tyr Arg 
                325                 330                 335     


Ser Arg Val Tyr Gln Met Ile Leu Glu Cys Gly Gly Ser Ser Gly Thr 
            340                 345                 350         


Ser Arg Glu Lys Gly Pro Glu Gly Val Ser Pro Ser Gln Ala His Leu 
        355                 360                 365             


His Lys Pro Arg Ala Asp Pro Gln Leu Pro Ser Arg Thr Pro Val Gln 
    370                 375                 380                 


Gly Pro Arg Pro Arg Pro Gln Ser Ser Pro Gly His Asp Pro Ala Glu 
385                 390                 395                 400 


His Glu Ser Pro Arg Ala Ala Lys Asn Val Pro Arg Gln Asn Ser Ala 
                405                 410                 415     


Pro Leu Leu Gln Thr Ala Leu Leu Gly Asn Gly Glu Arg Pro Pro Gly 
            420                 425                 430         


Ala Lys Glu Ala Pro Pro Leu Thr Leu Ser Leu Val Lys Pro Ser Gly 
        435                 440                 445             


Arg Gly Ala Ala Pro Ser Leu Thr Ser Gln Ala Ala Ala Gln Val Ala 
    450                 455                 460                 


Asn Gln Ala Leu Ile Arg Gly Asp Trp Asn Arg Gly Gly Gly Val Arg 
465                 470                 475                 480 


Val Ala Ser Val Gln Gln Val Pro Pro Arg Leu Pro Pro Glu Ala Arg 
                485                 490                 495     


Pro Gly Arg Arg Met Phe Ser Thr Ser Ala Leu Gln Gly Ala Gln Gly 
            500                 505                 510         


Gly Ala Arg Ala Leu Leu Gly Gly Tyr Ser Gln Ala Tyr Gly Thr Val 
        515                 520                 525             


Cys His Ser Ala Leu Gly His Leu Pro Leu Leu Glu Gly His His Val 
    530                 535                 540                 


<210>  5
<211>  1789
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, t or u

<400>  5
rgncccaagc cagagcggcg cggccggaag aggccagggc ccgggggagg cggcggcagc       60

ggcggcggcg gggcagcccg ggcagcccga gccccgcagc cgggccggcc ggcgccagag      120

cggcggcggg cccgggaggc ggcccggggg ccgggcaggg cgcggacagc cgcgcggagc      180

ccggcggcgg aggcggagga ggcggcggcg gccccggagg ccggccccgg cccaggcggc      240

accggcggcg gaaaggcacg cggggccagg ggggggcgcg gggcccgagc ccggggggga      300

cccggcggca gcggcggagg aggcagcgga ggccccggcg caggcacagc cccgccgccc      360

gggggaagcg ggccggacag cgggaaggga ccacagcgag ccaccaggcc aaggcccaga      420

gcgccccaag aagggcacac ggacacaaag gaggcaaggc caggggcgga ccaggcacgg      480

cggcagagac cagggaacag cgccacaaga aggcccagga caagaggcaa gaaccgagag      540

cgcagacagc gaagcggacc acgcaaagga ggcgagaacc acccagggcg agaagaaaga      600

cgagcaccaa acgggcggaa aggcccgaga caggaccggg ggcccgccac caccaaggcc      660

aaggaccacc cacccagcaa gggacagacc agccccgcag cggccacacc accccagggc      720

gggcaccgcg acacaagccc cagaaccgcg gggacccgac acgcgcccaa gccgcgaggc      780

aggcaaagca gggccgaggg gagcccaagc ccacacgccg cacaccgggc cccagagcca      840

cggagccacg aacacccacc acgagggcag cggcggacgg cagagccccg ggccagccca      900

ccccggggac agggggggac cagcggggag acacaagggc gggaacacca acccgggaac      960

aaaccgagag agaaccccaa cacacggagc aagccccaga aaagccaccc cggacaaagg     1020

gcaaaccgaa cgccgccaga ggccacgcgc cgccagccgc ggagacaccc cacccaaggc     1080

cccccacaga ggccggcgca cagccgagaa cgcgagcggg aacccagcgc caacaaccgc     1140

ccaccccccc ccaaccaggc gggaacccca ccaaccgccc aacgccacca ccccccacga     1200

ggccccagcg ggcacaccac cccaccccgc ccacaagcaa cgagacccga ccagccagac     1260

ggcagcgacc gagccacacc accccacaac ccccgagggc cccaccaagc acccccaccc     1320

acgggagccc caagaggggc gggaaggggg gccaagccca caagcccgcc cggcgggccc     1380

cagacagagg gcagaggaaa gagcccgccc caccccagcc cccccaccag cccaccccgg     1440

ggggcaagag gaaacggggg ggagggaaga gaaggacagg ggggggggag aggaccccac     1500

ccccggcccc cccccccccc agaccccacc ccccagaccc ccccccccgg cccgaaaaga     1560

accagcccag cccgcccccc ccccggcccc cggggaaaag agaaacaaag aaaacgcgac     1620

gcaccgccaa ccggccccgc cccccacagc gaaccccccc gcccgccccc aaggcacccc     1680

cccaccccac ccggagggcc aggggaggga gagagcccga gcagccacag aagggccgga     1740

cagaccccgc aaaaaaggca gaaaaccgaa aaaaaaaaaa aaaaaaaaa                 1789


<210>  6
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


<210>  7
<211>  2503
<212>  DNA
<213>  Homo sapiens

<400>  7
gcggagcgcg gcgcgcgcgg cgggggccgg gcgcggcccg ggaccgccgc cacccgcgac       60

agaccgccgg ccgcgagccg ccggagcacc ggacaagccg gcgccaacga gccgggggca      120

cgcccgcagc ggccaagcca ggccggcgag cgggacgccg ccccgcccag ccaccgccgc      180

cgccgccgcc cccccccagc cggcggcggc ccgggcccag caaccaggcg aagacacggg      240

acgggcgccg cggcgaacag gaggagaagg aggcgcgcgg cccacccggg ccgccgcccc      300

aggcgccgcc gcgccggccc cgcggccgag ggccgcgcgc ccccgccgac gccaggacgg      360

agaagaagac aaacggcagc gcaagacacc cgaggggccg aggcaagaca agaccaaggg      420

ccccgagcag aaggccggag agaggggggg ggcggcagga cccggagagg cccccacacg      480

gcgcccgggg aaccgcgcac ggggcccacc agccgcacca gagaggcacg aggacgaaga      540

ggggcgaggg gagaggacca ggccagccac gcccggagag ggcagcccag gagaggcgag      600

cgcaaccacc cccacgcaag acccacgagg acacaacaag cgccacacac cagcgacacc      660

ggcgccgagg gcaccggaga agcgacccca aagccccacg acaagccccc agccgccgcc      720

ccgcggcagc cacgagaggc gggaaacgga gaccacaaag cggacaaacg ggcgagggac      780

cagccaccgc acaaaggcaa aagcaagcca cagacaaccg ggcaccaagg agacagacgg      840

aacagaagag ggggcacccg caccgccacc gggaaggccc gccaaggacc caaacacgcc      900

aacacgacgc acagacaacc acacggagaa gccccacccg cgagaccgga caaggaccga      960

agcagaccgg agacggggaa cacacaacag cacaacggaa acgccgccag cgcccgggcc     1020

ggccacgcca ccggcagaag ggcacaccga gacccaagcc ccagaaccgc cacaacgaga     1080

ggggagagcc aagcggcgac ggccggcccg agccaagcaa cccaacaaag acaacccaag     1140

agggggacac gggaccggcc cccgacaccg cgggccacgg acacccacca gagacagggg     1200

gggggcgcac cagagaggcc acaggccgcc cccccgggcc cacggggagg aacagcacac     1260

cacccgacag gaaccccaac gaggagacgg gccaggcacc gccaacgagg agcaagacaa     1320

caacacccca agaccgagcc gaggcccgag ccacgcaccc cgacgaagcg acggggccga     1380

cccccaccaa gcggcaggag ggcgaaacgg acccgcagag gagccagaaa caccacccca     1440

gcgggggagc ggaccacaaa cccgacacac ccaagcacaa aggagacagc acaaaaggag     1500

gccagcccgg ccgcgagccg accaggcagg ccagcccgcg ggggacaccg agcaagccac     1560

agaccgaggc cccagcaggc agcggcggag ggagccacac ccccacaggg cagcccccaa     1620

cacaccccgc acccgccacc gccgagccag caccgcccac gccccgcgcc gcccaaacac     1680

cccaccaggc cgcaacccac ccaggccgcg cggggcaaca aagcccacac cccacggcgc     1740

gccgcggagg ccggggacag caggccggcc agcccccaca cgaggccagg caccccccac     1800

aaccagcccc caggaccaca ccccacggcc agccaggggc cagagcagcc caggcgggga     1860

ccgaccagac aagagggaca agccgagcga ggcacccgcc gcccgccgcc ccaccgccca     1920

agggggccgg cacagaaaaa agagagaaag caaaccgaac agacggcggg ccccaccccc     1980

gcggggcccc ccacagaggc aagaagcccg ccccagccca gagacaggga cacagcccca     2040

ggaacccgac acaccagacc cgggaggcag ggaaagcagc cacagccacc gccccacccc     2100

cgcccgccac cccaggcagg gggacgggga caccagagac cgggaaagga caaggggggg     2160

gccccacccc ccgcagcccg agcggggccc cccccagggc ccccagccca gccccgcccc     2220

acccaccggg cggggagggg cccgccagga acgaccagcc agcgaggagc caaaggcaag     2280

gcacaagcag gggggggagg ggggggaggg gggcccaggg gcccccaccc ggggagggga     2340

ggcagggcag ggacagccca gggcagcccg gagggggacc ccccccccac ccaagcccgg     2400

ggcccgaaag ggggggaggg caggggggga gcccccaggg gggggggggg ccgaagcacc     2460

aaacgcgaga aaaaaaaagc aaaggaaaaa aaaaaaaaaa aaa                       2503


<210>  8
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Lys Phe Lys Arg Arg Leu Ser Leu Thr Leu Arg Gly Ser Gln 
1               5                   10                  15      


Thr Ile Asp Glu Ser Leu Ser Glu Leu Ala Glu Gln Met Thr Ile Glu 
            20                  25                  30          


Glu Asn Ser Ser Lys Asp Asn Glu Pro Ile Val Lys Asn Gly Arg Pro 
        35                  40                  45              


Pro Thr Ser His Ser Met His Ser Phe Leu His Gln Tyr Thr Gly Ser 
    50                  55                  60                  


Phe Lys Lys Pro Pro Leu Arg Arg Pro His Ser Val Ile Gly Gly Ser 
65                  70                  75                  80  


Leu Gly Ser Phe Met Ala Met Pro Arg Asn Gly Ser Arg Leu Asp Ile 
                85                  90                  95      


Val His Glu Asn Leu Lys Met Gly Ser Asp Gly Glu Ser Asp Gln Ala 
            100                 105                 110         


Ser Gly Thr Ser Ser Asp Glu Val Gln Ser Pro Thr Gly Val Cys Leu 
        115                 120                 125             


Arg Asn Arg Ile His Arg Arg Ile Ser Met Glu Asp Leu Asn Lys Arg 
    130                 135                 140                 


Leu Ser Leu Pro Ala Asp Ile Arg Ile Pro Asp Gly Tyr Leu Glu Lys 
145                 150                 155                 160 


Leu Gln Ile Asn Ser Pro Pro Phe Asp Gln Pro Met Ser Arg Arg Ser 
                165                 170                 175     


Arg Arg Ala Ser Leu Ser Glu Ile Gly Phe Gly Lys Met Glu Thr Tyr 
            180                 185                 190         


Ile Lys Leu Glu Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val Tyr Lys 
        195                 200                 205             


Gly Arg Ser Lys Leu Thr Glu Asn Leu Val Ala Leu Lys Glu Ile Arg 
    210                 215                 220                 


Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu Val Ser 
225                 230                 235                 240 


Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His Asp Ile 
                245                 250                 255     


Val His Thr Asp Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu Asp Lys 
            260                 265                 270         


Asp Leu Lys Gln Tyr Met Asp Asp Cys Gly Asn Ile Met Ser Met His 
        275                 280                 285             


Asn Val Lys Leu Phe Leu Tyr Gln Ile Leu Arg Gly Leu Ala Tyr Cys 
    290                 295                 300                 


His Arg Arg Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu 
305                 310                 315                 320 


Ile Asn Glu Lys Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg 
                325                 330                 335     


Ala Lys Ser Val Pro Thr Lys Thr Tyr Ser Asn Glu Val Val Thr Leu 
            340                 345                 350         


Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Ser Glu Tyr Ser Thr 
        355                 360                 365             


Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Phe Glu Met Ala Ser 
    370                 375                 380                 


Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu Asp Glu Leu His Leu 
385                 390                 395                 400 


Ile Phe Arg Leu Leu Gly Thr Pro Ser Gln Glu Thr Trp Pro Gly Ile 
                405                 410                 415     


Ser Ser Asn Glu Glu Phe Lys Asn Tyr Asn Phe Pro Lys Tyr Lys Pro 
            420                 425                 430         


Gln Pro Leu Ile Asn His Ala Pro Arg Leu Asp Ser Glu Gly Ile Glu 
        435                 440                 445             


Leu Ile Thr Lys Phe Leu Gln Tyr Glu Ser Lys Lys Arg Val Ser Ala 
    450                 455                 460                 


Glu Glu Ala Met Lys His Val Tyr Phe Arg Ser Leu Gly Pro Arg Ile 
465                 470                 475                 480 


His Ala Leu Pro Glu Ser Val Ser Ile Phe Ser Leu Lys Glu Ile Gln 
                485                 490                 495     


Leu Gln Lys Asp Pro Gly Phe Arg Asn Ser Ser Tyr Pro Glu Thr Gly 
            500                 505                 510         


His Gly Lys Asn Arg Arg Gln Ser Met Leu Phe 
        515                 520             


<210>  9
<211>  1682
<212>  DNA
<213>  Homo sapiens

<400>  9
cttctctctg gcccgagcca ggtcagtccg gcagtgcaga tggcccatcc cgggctctgg       60

gctcctagac cggggtgggc cctgccagga gtgggcctga gcctcgcacg tcctctgaaa      120

ctacgctatg ctctgctttt gcggcgcgat gggcgtggga gcgggggctg cccaaagatg      180

ggctggggtt ggaggaagtg gcccggtagc cgctgtgtgt cctgaggccg taaggcgcct      240

gaccccaccc ctgaagctgg cgacggagca gggcctgttt tctctacact atagtcatga      300

tccgctgggc ccccagcgca tctcctggaa gagcccactc accctggacg agctcttcgg      360

tagcctcaga ccgtccttga agaggatgac tgagacatta tgggccacgc gctgtgtgtc      420

tgctctcggg gaactgtcat cattgacaat aagcgctacc tcttcatcca gaaactgggg      480

gagggtgggt tcagctatgt ggacctagtg gaagggttac atgatggaca cttctacgcc      540

ctgaagcgaa tcctgtgtca cgagcagcag gaccgggagg aggcccagcg agaagccgac      600

atgcatcgcc tcttcaatca ccccaacatc cttcgcctcg tggcttactg tctgagggaa      660

cggggtgcta agcatgaggc ctggctgctg ctaccattct tcaagagagg tacgctgtgg      720

aatgagatag aaaggctgaa ggacaaaggc aacttcctga ccgaggatca aatcctttgg      780

ctgctgctgg ggatctgcag aggccttgag gccattcatg ccaagggtta tgcccacaga      840

gacttgaagc ccaccaatat attgcttgga gatgaggggc agccagtttt aatggacttg      900

ggttccatga atcaagcatg catccatgtg gagggctccc gccaggctct gaccctgcag      960

gactgggcag cccagcggtg caccatctcc taccgagccc cagagctctt ctctgtgcag     1020

agtcactgtg tcatcgatga gcggactgat gtctggtccc taggctgcgt gctatatgcc     1080

atgatgtttg gggaaggccc ttatgacatg gtgttccaaa agggtgacag tgtggccctt     1140

gctgtgcaga accaactcag catcccacaa agccccaggc attcttcagc attgcggcag     1200

ctcctgaact cgatgatgac cgtggacccg catcagcgtc ctcacattcc tctcctcctc     1260

agtcagctgg aggcgctgca gcccccagct cctggccaac atactaccca aatctgaaaa     1320

agcagcatgt tgagaagatg gccccttgtg ccttggaaag aggttcccat ccctcattgg     1380

aatcaccacc cattccatcc aggacttctc ttacacttgg gggtagcggg gtcaggacaa     1440

tcatctcagt cctgcatctt ttcttctgct ttcttccctc caagagcaaa acctgggcaa     1500

ggggacttac tgagtggggg tgggtggggg ttgggaaaag ggaaactggt gggatatgga     1560

acatggctct gagcaggact gttgagctca catagtgttc tgactccaaa tctgggagca     1620

ggagaatgtg taaacaagaa taaagtggaa gcaggttggt gtagaaaaaa aaaaaaaaaa     1680

aa                                                                    1682


<210>  10
<211>  2984
<212>  DNA
<213>  Homo sapiens

<400>  10
ggaaattcaa acgtgtttgc ggaaaggagt ttgggttcca tcttttcatt tccccagcgc       60

agctttctgt agaaatggaa tccgaggatt taagtggcag agaattgaca attgattcca      120

taatgaacaa agtgagagac attaaaaata agtttaaaaa tgaagacctt actgatgaac      180

taagcttgaa taaaatttct gctgatacta cagataactc gggaactgtt aaccaaatta      240

tgatgatggc aaacaaccca gaggactggt tgagtttgtt gctcaaacta gagaaaaaca      300

gtgttccgct aagtgatgct cttttaaata aattgattgg tcgttacagt caagcaattg      360

aagcgcttcc cccagataaa tatggccaaa atgagagttt tgctagaatt caagtgagat      420

ttgctgaatt aaaagctatt caagagccag atgatgcacg tgactacttt caaatggcca      480

gagcaaactg caagaaattt gcttttgttc atatatcttt tgcacaattt gaactgtcac      540

aaggtaatgt caaaaaaagt aaacaacttc ttcaaaaagc tgtagaacgt ggagcagtac      600

cactagaaat gctggaaatt gccctgcgga atttaaacct ccaaaaaaag cagctgcttt      660

cagaggagga aaagaagaat ttatcagcat ctacggtatt aactgcccaa gaatcatttt      720

ccggttcact tgggcattta cagaatagga acaacagttg tgattccaga ggacagacta      780

ctaaagccag gtttttatat ggagagaaca tgccaccaca agatgcagaa ataggttacc      840

ggaattcatt gagacaaact aacaaaacta aacagtcatg cccatttgga agagtcccag      900

ttaaccttct aaatagccca gattgtgatg tgaagacaga tgattcagtt gtaccttgtt      960

ttatgaaaag acaaacctct agatcagaat gccgagattt ggttgtgcct ggatctaaac     1020

caagtggaaa tgattcctgt gaattaagaa atttaaagtc tgttcaaaat agtcatttca     1080

aggaacctct ggtgtcagat gaaaagagtt ctgaacttat tattactgat tcaataaccc     1140

tgaagaataa aacggaatca agtcttctag ctaaattaga agaaactaaa gagtatcaag     1200

aaccagaggt tccagagagt aaccagaaac agtggcaatc taagagaaag tcagagtgta     1260

ttaaccagaa tcctgctgca tcttcaaatc actggcagat tccggagtta gcccgaaaag     1320

ttaatacaga gcagaaacat accacttttg agcaacctgt cttttcagtt tcaaaacagt     1380

caccaccaat atcaacatct aaatggtttg acccaaaatc tatttgtaag acaccaagca     1440

gcaatacctt ggatgattac atgagctgtt ttagaactcc agttgtaaag aatgactttc     1500

cacctgcttg tcagttgtca acaccttatg gccaacctgc ctgtttccag cagcaacagc     1560

atcaaatact tgccactcca cttcaaaatt tacaggtttt agcatcttct tcagcaaatg     1620

aatgcatttc ggttaaagga agaatttatt ccattttaaa gcagatagga agtggaggtt     1680

caagcaaggt atttcaggtg ttaaatgaaa agaaacagat atatgctata aaatatgtga     1740

acttagaaga agcagataac caaactcttg atagttaccg gaacgaaata gcttatttga     1800

ataaactaca acaacacagt gataagatca tccgacttta tgattatgaa atcacggacc     1860

agtacatcta catggtaatg gagtgtggaa atattgatct taatagttgg cttaaaaaga     1920

aaaaatccat tgatccatgg gaacgcaaga gttactggaa aaatatgtta gaggcagttc     1980

acacaatcca tcaacatggc attgttcaca gtgatcttaa accagctaac tttctgatag     2040

ttgatggaat gctaaagcta attgattttg ggattgcaaa ccaaatgcaa ccagatacaa     2100

caagtgttgt taaagattct caggttggca cagttaatta tatgccacca gaagcaatca     2160

aagatatgtc ttcctccaga gagaatggga aatctaagtc aaagataagc cccaaaagtg     2220

atgtttggtc cttaggatgt attttgtact atatgactta cgggaaaaca ccatttcagc     2280

agataattaa tcagatttct aaattacatg ccataattga tcctaatcat gaaattgaat     2340

ttcccgatat tccagagaaa gatcttcaag atgtgttaaa gtgttgttta aaaagggacc     2400

caaaacagag gatatccatt cctgagctcc tggctcatcc ctatgttcaa attcaaactc     2460

atccagttaa ccaaatggcc aagggaacca ctgaagaaat gaaatatgtt ctgggccaac     2520

ttgttggtct gaattctcct aactccattt tgaaagctgc taaaacttta tatgaacact     2580

atagtggtgg tgaaagtcat aattcttcat cctccaagac ttttgaaaaa aaaaggggaa     2640

aaaaatgatt tgcagttatt cgtaatgtca aataccacct ataaaatata ttggactgtt     2700

atactcttga atccctgtgg aaatctacat ttgaagacaa catcactctg aagtgttatc     2760

agcaaaaaaa attcagtaga ttatctttaa aagaaaactg taaaaatagc aaccacttat     2820

ggtactgtat atattgtaga cttgttttct ctgttttatg ctcttgtgta atctacttga     2880

catcatttta ctcttggaat agtgggtgga tagcaagtat attctaaaaa actttgtaaa     2940

taaagttttg tggctaaaat gacactaaaa aaaaaaaaaa aaaa                      2984


<210>  11
<211>  2178
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, t or u

<400>  11
rgngctcacg gcggcggcgg cggagcggag aggccagagc cggagaccga gctgggatcg       60

ggccccgggc gggggcggtg cgagcggcgc caagcagatc ttaggggcgg ggacggagcc      120

ggggcgggcg ggactgaagc ggagcccggg aacggggcgg gaggtcccag ggtcccgggt      180

tgggggggtg gagcagcatt tcgtcgccgc gggggtgccg ggactccggc cgcagtgtcg      240

ccgccatcac ggacttcctg tgggacaagc gcacgggcct cgccgccaga acgatgccgc      300

atcctcgaag gtaccactcc tcagagcgag gcagccgggg gagttaccgt gaacactatc      360

ggagccgaaa gcataagcga cgaagaagtc gctcctggtc aagtagtagt gaccggacac      420

gacggcgtcg gcgagaggac agctaccatg tccgttctcg aagcagttat gatgatcgtt      480

cgtccgaccg gagggtgtat gaccggcgat actgtggcag ctacagacgc aacgattata      540

gccgggatcg gggagatgcc tactatgaca cagactatcg gcattcctat gaatatcagc      600

gggagaacag cagttaccgc agccagcgca gcagccggag gaagcacaga cggcggagga      660

ggcgcagccg gacatttagc cgctcatctt cgcacagcag ccggagagcc aagagtgtag      720

aggacgacgc tgagggccac ctcatctacc acgtcgggga ctggctacaa gagcgatatg      780

aaatcgttag caccttagga gaggggacct tcggccgagt tgtacaatgt gttgaccatc      840

gcaggggtgg ggctcgagtt gccctgaaga tcattaagaa tgtggagaag tacaaggaag      900

cagctcgact tgagatcaac gtgctagaga aaatcaatga gaaagaccct gacaacaaga      960

acctctgtgt ccagatgttt gactggtttg actaccatgg ccacatgtgt atctcctttg     1020

agcttctggg ccttagcacc ttcgatttcc tcaaagacaa caactacctg ccctacccca     1080

tccaccaagt gcgccacatg gccttccagc tgtgccaggc tgtcaagttc ctccatgata     1140

acaagctgac acatacagac ctcaagcctg aaaatattct gtttgtgaat tcagactatg     1200

agctcaccta caacctagag aagaagcgag atgagcgcag tgtgaagagc acagctgtgc     1260

gggtggtaga ctttggcagt gccacctttg accatgagca ccatagcacc attgtctcca     1320

ctcgccatta ccgagcacca gaagtcatcc ttgagttggg ctggtcacag ccttgtgatg     1380

tgtggagtat aggctgcatc atctttgaat actatgtggg attcaccctc ttccagaccc     1440

atgacaacag agagcatcta gccatgatgg aaaggatctt gggtcctatc ccttcccgga     1500

tgatccgaaa gacaagaaag cagaaatatt tttaccgggg tcgcctggat tgggatgaga     1560

acacatcagc tgggcgctat gttcgtgaga actgcaaacc gctgcggcgg tatctgacct     1620

cagaggcaga ggaacaccac cagctcttcg atctgattga aagcatgcta gagtatgaac     1680

cagctaagcg gctgaccttg ggtgaagccc ttcagcatcc tttcttcgcc cgccttcggg     1740

ctgagccgcc caacaagttg tgggactcca gtcgggatat cagtcggtga cgatcaggcc     1800

ctgggccccc ctgcatcttt tatagcagtg ggtgtccagt ccaggacact ggtgcttttt     1860

tatacaagag aacgagccag agttcactcc ttcctcctgg ctctctatat acctgtgaat     1920

atgtgaaata gtgtaaatat gaaagaactt gtacctatca cttcaacccc tgccttgtac     1980

ataatactat tccatccaca cagtttccac cctcacctgc cccctcatac ggagttggat     2040

gggggccgag tgaggtaacc aggtggcatc taccccatgt tttataagga attttgtaca     2100

gtctttgtga aataaaataa cgtgcttcat ttgaccccca aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaa                                                   2178


<210>  12
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu 
1               5                   10                  15      


Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly 
            20                  25                  30          


Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile 
        35                  40                  45              


Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg 
    50                  55                  60                  


Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
65                  70                  75                  80  


Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly 
                85                  90                  95      


Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu 
            100                 105                 110         


Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His 
        115                 120                 125             


Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His 
    130                 135                 140                 


Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile 
145                 150                 155                 160 


Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu 
            180                 185                 190         


Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn 
        195                 200                 205             


Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu 
    210                 215                 220                 


Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln 
225                 230                 235                 240 


Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg 
                245                 250                 255     


Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr 
            260                 265                 270         


Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu 
        275                 280                 285             


Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg 
    290                 295                 300                 


Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser 
305                 310                 315                 320 


Phe Pro Met Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp 
                325                 330                 335     


Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr 
            340                 345                 350         


Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro 
        355                 360                 365             


Val His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala 
    370                 375                 380                 


Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys 
385                 390                 395                 400 


Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp 
                405                 410                 415     


Thr Asn Tyr Ser Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu 
            420                 425                 430         


Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr 
        435                 440                 445             


Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val 
    450                 455                 460                 


Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys 
465                 470                 475                 480 


Glu Gln Ser Lys Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys Glu 
                485                 490                 495     


Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln 
            500                 505                 510         


Gln Leu Ala Gly Lys Glu Arg Glu Lys Asn Gln Gly Phe Asp Phe Asp 
        515                 520                 525             


Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln His Glu Pro Thr 
    530                 535                 540                 


Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu 
545                 550                 555                 560 


Glu Leu Lys Ser Leu Ile Ser Lys Ser Val Ser Gln Glu Lys Gln Glu 
                565                 570                 575     


Lys Gly Met Ala Asn Leu Ala Gln Leu Glu Ala Leu Tyr Gln Ser Ser 
            580                 585                 590         


Trp Asp Ser Gln Phe Val Ser Gly Gly Glu Asp Cys Phe Phe Ile Asn 
        595                 600                 605             


Gln Phe Cys Glu Val Arg Lys Asp Glu Gln Val Glu Lys Glu Asn Thr 
    610                 615                 620                 


Tyr Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu 
625                 630                 635                 640 


Met Leu Glu Thr Glu Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly 
                645                 650                 655     


His Glu Glu Gly Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys 
            660                 665                 670         


Gln Leu Glu Ser Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser 
        675                 680                 685             


Pro Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser 
    690                 695                 700                 


Ser Pro Gln Ile Pro His Gln Thr Tyr Ser Ser Ile Leu Lys His Leu 
705                 710                 715                 720 


Asn 
    


<210>  13
<211>  2930
<212>  DNA
<213>  Homo sapiens

<400>  13
agcagacgag ggcttgtgcg agagggggcc gggcggctgc agggaaggcg gagtccaagg       60

ggaaaacgaa actgagaacc agctctcccg aagccgcggg tctccggccg gcggcggcgg      120

cggcggcggc ggcggcgcag tttgctcata ctttgtgact tgcggtcaca gtggcattca      180

gctccacact tggtagaacc acaggcacga caagcataga aacatcctaa acaatcttca      240

tcgaggcatc gaggtccatc ccaataaaaa tcaggagacc ctggctatca tagaccttag      300

tcttcgctgg tatcactcgt ctgtctgaac cagcggttgc atttttttaa gccttctttt      360

ttctctttta ccagtttctg gagcaaattc agtttgcctt cctggatttg taaattgtaa      420

tgacctcaaa actttagcag ttcttccatc tgactcaggt ttgcttctct ggcggtcttc      480

agaatcaaca tccacacttc cgtgattatc tgcgtgcatt ttggacaaag cttccaacca      540

ggatacggga agaagaaatg gctggtgatc tttcagcagg tttcttcatg gaggaactta      600

atacataccg tcagaagcag ggagtagtac ttaaatatca agaactgcct aattcaggac      660

ctccacatga taggaggttt acatttcaag ttataataga tggaagagaa tttccagaag      720

gtgaaggtag atcaaagaag gaagcaaaaa atgccgcagc caaattagct gttgagatac      780

ttaataagga aaagaaggca gttagtcctt tattattgac aacaacgaat tcttcagaag      840

gattatccat ggggaattac ataggcctta tcaatagaat tgcccagaag aaaagactaa      900

ctgtaaatta tgaacagtgt gcatcggggg tgcatgggcc agaaggattt cattataaat      960

gcaaaatggg acagaaagaa tatagtattg gtacaggttc tactaaacag gaagcaaaac     1020

aattggccgc taaacttgca tatcttcaga tattatcaga agaaacctca gtgaaatctg     1080

actacctgtc ctctggttct tttgctacta cgtgtgagtc ccaaagcaac tctttagtga     1140

ccagcacact cgcttctgaa tcatcatctg aaggtgactt ctcagcagat acatcagaga     1200

taaattctaa cagtgacagt ttaaacagtt cttcgttgct tatgaatggt ctcagaaata     1260

atcaaaggaa ggcaaaaaga tctttggcac ccagatttga ccttcctgac atgaaagaaa     1320

caaagtatac tgtggacaag aggtttggca tggattttaa agaaatagaa ttaattggct     1380

caggtggatt tggccaagtt ttcaaagcaa aacacagaat tgacggaaag acttacgtta     1440

ttaaacgtgt taaatataat aacgagaagg cggagcgtga agtaaaagca ttggcaaaac     1500

ttgatcatgt aaatattgtt cactacaatg gctgttggga tggatttgat tatgatcctg     1560

agaccagtga tgattctctt gagagcagtg attatgatcc tgagaacagc aaaaatagtt     1620

caaggtcaaa gactaagtgc cttttcatcc aaatggaatt ctgtgataaa gggaccttgg     1680

aacaatggat tgaaaaaaga agaggcgaga aactagacaa agttttggct ttggaactct     1740

ttgaacaaat aacaaaaggg gtggattata tacattcaaa aaaattaatt catagagatc     1800

ttaagccaag taatatattc ttagtagata caaaacaagt aaagattgga gactttggac     1860

ttgtaacatc tctgaaaaat gatggaaagc gaacaaggag taagggaact ttgcgataca     1920

tgagcccaga acagatttct tcgcaagact atggaaagga agtggacctc tacgctttgg     1980

ggctaattct tgctgaactt cttcatgtat gtgacactgc ttttgaaaca tcaaagtttt     2040

tcacagacct acgggatggc atcatctcag atatatttga taaaaaagaa aaaactcttc     2100

tacagaaatt actctcaaag aaacctgagg atcgacctaa cacatctgaa atactaagga     2160

ccttgactgt gtggaagaaa agcccagaga aaaatgaacg acacacatgt tagagccctt     2220

ctgaaaaagt atcctgcttc tgatatgcag ttttccttaa attatctaaa atctgctagg     2280

gaatatcaat agatatttac cttttatttt aatgtttcct ttaatttttt actattttta     2340

ctaatctttc tgcagaaaca gaaaggtttt cttctttttg cttcaaaaac attcttacat     2400

tttacttttt cctggctcat ctctttattc tttttttttt tttaaagaca gagtctcgct     2460

ctgttgccca ggctggagtg caatgacaca gtcttggctc actgcaactt ctgcctcttg     2520

ggttcaagtg attctcctgc ctcagcctcc tgagtagctg gattacaggc atgtgccacc     2580

cacccaacta atttttgtgt ttttaataaa gacagggttt caccatgttg gccaggctgg     2640

tctcaaactc ctgacctcaa gtaatccacc tgcctcggcc tcccaaagtg ctgggattac     2700

agggatgagc caccgcgccc agcctcatct ctttgttcta aagatggaaa aaccaccccc     2760

aaattttctt tttatactat taatgaatca atcaattcat atctatttat taaatttcta     2820

ccgcttttag gccaaaaaaa tgtaagatcg ttctctgcct cacatagctt acaagccagc     2880

tggagaaata tggtactcat taaaaaaaaa aaaaaaagtg atgtacaacc                2930


<210>  14
<211>  1770
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, t or u

<400>  14
rgncagcggc ggtggcccag gtagaggggt ccgcgctggc ggcggcggcg gcgctgttcc       60

ccgcgcggtc cgcggagcgg ggtccgggct gcgcgacgtg gggcggcggc ggcactgcgg      120

ccccggccca agcccgaccc cgggtcccct cctcggccgc cccccgcccg gccgcccgcc      180

ctcgggcctc cccccgggcc ctcggtcccc tcccccgctg gcggggcccg gacagaagat      240

ggtgcagaag aaaccagccg aacttcaggg tttccaccgt tcgttcaagg ggcagaaccc      300

cttcgagctg gccttctccc tagaccagcc cgaccacgga gactctgact ttggcctgca      360

gtgctcagcc cgccctgaca tgcccgccag ccagcccatt gacatcccgg acgccaagaa      420

gaggggcaag aagaagaagc gcggccgggc caccgacagc ttctcgggca ggtttgaaga      480

cgtctaccag ctgcaggaag atgtgctggg ggagggcgct catgcccgag tgcagacctg      540

catcaacctg atcaccagcc aggagtacgc cgtcaagatc attgagaagc agccaggcca      600

cattcggagc agggttttca gggaggtgga gatgctgtac cagtgccagg gacacaggaa      660

cgtcctagag ctgattgagt tcttcgagga ggaggaccgc ttctacctgg tgtttgagaa      720

gatgcgggga ggctccatcc tgagccacat ccacaagcgc cggcacttca acgagctgga      780

ggccagcgtg gtggtgcagg acgtggccag cgccttggac tttctgcata acaaaggcat      840

cgcccacagg gacctaaagc cggaaaacat cctctgtgag caccccaacc aggtctcccc      900

cgtgaagatc tgtgacttcg acctgggcag cggcatcaaa ctcaacgggg actgctcccc      960

tatctccacc ccggagctgc tcactccgtg cggctcggcg gagtacatgg ccccggaggt     1020

agtggaggcc ttcagcgagg aggctagcat ctacgacaag cgctgcgacc tgtggagcct     1080

gggcgtcatc ttgtatatcc tactcagcgg ctacccgccc ttcgtgggcc gctgtggcag     1140

cgactgcggc tgggaccgcg gcgaggcctg ccctgcctgc cagaacatgc tgtttgagag     1200

catccaggag ggcaagtacg agttccccga caaggactgg gcccacatct cctgcgctgc     1260

caaagacctc atctccaagc tgctggtccg tgacgccaag cagaggctga gtgccgccca     1320

agtcctgcag cacccctggg ttcaggggtg cgccccggag aacaccttgc ccactcccat     1380

ggtcctgcag aggtgggaca gtcacttcct cctccctccc cacccctgtc gcatccacgt     1440

gcgacctgga ggactggtca gaaccgttac tgtgaatgag tgaagatcct ggaggaccct     1500

gggccccagg ccagctccca tcgctggggg acggtgaacg gccatgtgtt aatgttacga     1560

tgtttttaaa agacaaaaaa aaaaaaaaaa cctcaaaagt ttttttaaag tgggggaaaa     1620

acatccaagc actttaattc caatgtacca ggtgaactga cggagctcag aagttttcct     1680

ttacaccaac tgtcaatgcc ggaattttgt attctgtttt gtaaagattt aataaaagtc     1740

aaaaaacttg caaaaaaaaa aaaaaaaaaa                                      1770


<210>  15
<211>  5760
<212>  DNA
<213>  Homo sapiens

<400>  15
agagagaaga tacttcctct cgtagtggac acttgtcttt tcagaagatt tatacgactg       60

agagtcaaaa cttttaccag agactttcat agtcagtttg aattctgcaa aatttctctt      120

tatcttctgg aatgtatgct ctagacttgg agtggctcaa gctcttcgat gtgatcctat      180

caatgtcaag agaaagaagc actgaagagt cataattgtg tcctgattta taaatcggag      240

acagagggag acgaaaacca cactccagaa agtagcttaa tcggactcac tactaagatg      300

ttaaaagtga agaggctgga agaattcaac acgtgttata acagcaacca gctggagaaa      360

atggcctttt ttcagtgcag ggaagaggtg gagaaagtga agtgttttct ggaaaaaaat      420

tctggggacc aggattcaag atctggacat aatgaggcga aggaggtgtg gtcaaacgcc      480

gacctgacgg aaaggatgcc cgtcaaaagc aaaaggacat cagccctcgc agttgacatc      540

ccggctcctc cggccccatt tgatcatcgt attgtgacag ccaagcaagg agcggtcaac      600

agcttctata ctgtgagcaa gacagaaatc ctaggaggag ggcgtttcgg ccaggttcac      660

aagtgtgagg agacggccac aggtctgaag ctggcagcca aaatcatcaa gaccagaggc      720

atgaaggaca aggaggaggt gaagaacgag atcagcgtca tgaaccagct ggaccacgcg      780

aacctcatcc agctgtacga tgccttcgag tctaagaacg acattgtcct ggtcatggag      840

tatgtggatg gtggggagct gtttgaccgc atcatcgatg agagctacaa tttgacggag      900

cttgatacca tcctgttcat gaagcagata tgtgagggga taaggcacat gcatcagatg      960

tacattctcc acttggacct gaagcctgag aatatcctgt gtgtgaatcg ggatgctaag     1020

caaataaaaa ttattgattt tggattggcc agaagataca aacccagaga gaagctgaag     1080

gtgaactttg gaaccccaga atttctcgcc cctgaagttg tgaactatga ttttgtttca     1140

tttcccactg acatgtggag tgtgggggtc atcgcctata tgctacttag cggtttgtcg     1200

cctttcctgg gtgacaatga tgctgagacg ctgaacaaca tcctggcctg caggtgggac     1260

ttagaggatg aagaatttca ggacatctcg gaggaggcca aggagttcat ctctaagctt     1320

ctgattaagg agaagagttg gcgaataagt gcaagcgaag ctctcaagca cccctggttg     1380

tcagaccaca agctccactc cagactcaat gcccagaaga agaagaatcg tggctctgat     1440

gcccaggact ttgtgaccaa atagtctaca ggaggcagcc atttggaagg aaaactgctg     1500

tggttgctgc tgcttcgaga aaattttttg aaaaatcagc agttctgatg ccttgacccc     1560

tgtgatgacc tggtagtctt agcaggggga gccctcgacc ctgaatgtga acttgaactg     1620

gagtgcctct gctgcgctca gaggaacacc cagcgctgcg gtctggtctc agggcgcaaa     1680

cacatccctg cacccggtgg tggtgatgtt gggaagatgt ttccctgcca tcttgagatt     1740

ttttactttt ttaaaaaaat tttttgatct tagtcactgg ggcagggggt gcattatgtc     1800

tgccatttct caaatgacta cagctgtgac acttaagatt gattggagat tttaaaactg     1860

gaggatgcat ttagagggag aaagctactt ccagccatta gactatgcct ttggaagggg     1920

caattagatg gccagaaaga attctgactc ccatgcaccc ttggagactt agtttcacag     1980

actctgtcat tttgatttgg tctgtggtca cgtgactaca atggataaat aatttgtttg     2040

ctggaacaga agccgtcttt gaattctcca acaagaggca tcagccactg tgtctttcat     2100

ttattctgaa ttgtccccag cgtgcgtttt cttccatgta gctgattctg tttttcacat     2160

ctatactccc tgcacccttc tgactgacag ttcatcccca caaaacacat tggttttgag     2220

aggtgatgca aaaagtatct gtttatggtt ggactttgaa attctgacct ttgaaataat     2280

gtcaacagtc acaacaggtt tcctcaagcc ccatttgtca actaaaagag acggatctgc     2340

acctcctgga gcaagatagc actgagcttt caacattgaa gtgacttggg aaataacatt     2400

caagcttctg ggtaaacaca tacaaacagt ggcaaagacc aagtacagtc tctcgcctgt     2460

gctgtctcat gggactcaat ggtggtgaag aaatctcaat cggacaccag aggtgggggc     2520

aactctgcaa gctcacctgc tggacgtgag aatgttggaa cgttccagtt ggaaggttcc     2580

tatgcctagc ctgtgtgcca tttcatggca gatatgtaag aaaggaaatg gccctactgt     2640

agacagctta tggggcccag aaaggcactg ggctttaaag agcgaaatga gtgtgtcatt     2700

tccacatgaa ggagaggcaa ggaaaagccc cacaaaattc ctgttacccg ctgaactcca     2760

agctcaccaa ccagattcat gagctttctc acattttcca tttccaaata actgttgtgt     2820

tgaatcagct gtgttaatgc ctttattctt tgtttttttt ttttagacgg agtctcgctc     2880

tgtcacgagg ctggagtgca gtggccccat ctcggctcac tgcaacctcc gcctcccagg     2940

ttcaagcgat tctcctgcag cctcccgagt agctgggatt acaggcgcac gccaccacgc     3000

acggctgatt tttgcatttt tagtagagat ggggtttctc catgttggcc agaatggtct     3060

caattactgt tgtcgcaata gcaatgaaag gcataagaat tacttggtgg cctcatgagg     3120

gatggcagtt tcactttgca tcagctttcc cccattatct ctcagatcca cttaaggaat     3180

ccttacagca tgccgtgaat gtgtgcaaca tccttattct catctttaag gtaaggagga     3240

agtagagata gaaggaaata cgtgatttgg tgaaggccac atgcgaattt tgtggtcgtg     3300

ttagttataa aactgactcc tttccagcct ttgctcttac attatgatgc gtttcttttt     3360

ctcctttggc cttgcattta tccgaggttg gtttcttatg ttcctgtgat gtgactatgc     3420

ttaagtgttt aatttagttt gcttaaaaca cacacaccac acacacacac acacacaaaa     3480

ccctgtgact ggagtgttat attactatgc tatctttagc tgatgatatt cattgagcct     3540

ggaaaaatac aagccagtgc atgcattaat acttagttag accgcagaga gctggcattc     3600

actcaaatgc taaacaggac acaggggtct gatttgaagc ccctcgtggc agggcgtttt     3660

ctgtcctgtg gtgtgcattc tctaccaaat caagcaggag atcttttgca cgacgtgcaa     3720

tttgcatcca ccttcccttc tgactcaggt tggcagataa actgtcccca gaccctgcca     3780

cacatggaag agacagctca ggccaaatac aggcatgatt tctttgccaa gttaatgcac     3840

tgatgaccct gcagtgagtg ggtgtgattt ttgttttgtt ttgaggttta gaaaggagac     3900

tgtactttga aaatggatct tgtttgattc tgtagttaaa tttccacatt tggaatggga     3960

aggcatctcc atgccagcag ggtgcctttt atatgagtgc tgagggtagt ttgcattgca     4020

gagttcatga ttacagtcta gagttacttg aaatgggaga ttatcagtct agtgttcatc     4080

ccgcccctgc tccatgtcct tgtgtggctg ctccagcgag agctggtaac taggtagact     4140

gctgctctaa tggggaaagg gggctttgca aagccgagga atcaagccag atgcgagcat     4200

ggactcagaa aagctgagtc tggctagacc agggctatgg agatcaattt ttccaacagg     4260

tcattaggat ttgggaggct gtatttctcc tccaccctct taatggatgg tatggctttg     4320

ctcactcact aggcagttcc cactttcttt agcaaatgga ggaaattaag caccgatgta     4380

gcacttccca ctgcctggag agaaataaac ctcgcaagtt attaaggaga aggcatgcct     4440

cattggtaat ttggaagaca ccaacactta cccagaatct gttgctattt aaaaatcagg     4500

gagaggaggg cacatgtccc catttgctac attacaaact ttggacgaga ctctcatctg     4560

aactaacttg gggaaacaat ttctaggttg aagctggtaa cactcatgtc tgttgagtgc     4620

cataagtttg ttttcagtta tttcctctaa cttgatatta atttgctttc tttcctcaaa     4680

aatgtaagta ggcatgttgc cattgttgtg gcttgctttg atgtatgttt ggaaagatgt     4740

gtgaatactt aatttttatc cattttatgg aaattagctt agcaattttt ttttctcttt     4800

taagaatcaa aatatggatt tgatactagg aacagaatct gctctttatt tcattccttt     4860

tttgtctctt ctgcttcctc tgcccctccc ccagccacgc agcacgggtg ccagtgtgca     4920

tgcgtgtgct gggggccaaa tgacagaacc ccggttgaaa gtccgcttgt aaaagcacaa     4980

gtgagaggca gcatcaggcc cctggagggc tgtggtcctc ggactcggtt ctttcctgtc     5040

ccctggccgt cctgtcatcc ctgtgtgctg cagcatcacc acggcctact tcccaatatc     5100

cacaaagctt cgcctttgct tttgcactct cttttacatt tttttacttc tttccttttt     5160

cttaagttcg gatccaagtt tgtcttctta tccatcacca tgctccctga aagccttttt     5220

gagattaaga aattttctta ccaggaggca actttccgtc tgtcctaaag ggaagtgggt     5280

gctggattta ttagatattg ggttcctgga ttaagatgac ttcctcacat agcttggagt     5340

ctgcagtttc tcagttagaa gtgttctata tttctttttg ctccatttta gtgcgctgtg     5400

ctttgtataa gtggtctttc tatgggcagt ttcaccttcc atgaaggctt ataactcaac     5460

cactactacc cattcagaag agcagaaagc atctgctgtg tgagcgttca tatgttacct     5520

aatgtgtatt ttgctgtcgt ctcagctgat agatgtcagt gagtctttct gactaggttt     5580

attggtgttg ataagaaatt aaaaaaagga ttcataacgt ggtgattgtg tctatcatgt     5640

atattttaaa tttctgaacg tactttcatt tagctgtttt tctttgcttt ctaaagatgt     5700

ataacaatca tgtatatgta ttatattgaa gaataaacat ggaccttatt tatcttttga     5760


<210>  16
<211>  2101
<212>  DNA
<213>  Homo sapiens

<400>  16
cgcgcgcggc gaatctcaac gctgcgccgt ctgcgggcgc ttccgggcca ccagtttctc       60

tgctttccac cctggcgccc cccagccctg gctccccagc tgcgctgccc cgggcgtcca      120

cgccctgcgg gcttagcggg ttcagtgggc tcaatctgcg cagcgccacc tccatgttga      180

ccaagcctct acaggggcct cccgcgcccc ccgggacccc cacgccgccg ccaggaggca      240

aggatcggga agcgttcgag gccgagtatc gactcggccc cctcctgggt aaggggggct      300

ttggcaccgt cttcgcagga caccgcctca cagatcgact ccaggtggcc atcaaagtga      360

ttccccggaa tcgtgtgctg ggctggtccc ccttgtcaga ctcagtcaca tgcccactcg      420

aagtcgcact gctatggaaa gtgggtgcag gtggtgggca ccctggcgtg atccgcctgc      480

ttgactggtt tgagacacag gagggcttca tgctggtcct cgagcggcct ttgcccgccc      540

aggatctctt tgactatatc acagagaagg gcccactggg tgaaggccca agccgctgct      600

tctttggcca agtagtggca gccatccagc actgccattc ccgtggagtt gtccatcgtg      660

acatcaagga tgagaacatc ctgatagacc tacgccgtgg ctgtgccaaa ctcattgatt      720

ttggttctgg tgccctgctt catgatgaac cctacactga ctttgatggg acaagggtgt      780

acagcccccc agagtggatc tctcgacacc agtaccatgc actcccggcc actgtctggt      840

cactgggcat cctcctctat gacatggtgt gtggggacat tccctttgag agggaccagg      900

agattctgga agctgagctc cacttcccag cccatgtctc cccagactgc tgtgccctaa      960

tccgccggtg cctggccccc aaaccttctt cccgaccctc actggaagag atcctgctgg     1020

acccctggat gcaaacacca gccgaggatg tacccctcaa cccctccaaa ggaggccctg     1080

cccctttggc ctggtccttg ctaccctaag cctggcctgg cctggcctgg cccccaatgg     1140

tcagaagagc catcccatgg ccatgtcaca gggatagatg gacatttgtt gacttggttt     1200

tacaggtcat taccagtcat taaagtccag tattactaag gtaagggatt gaggatcagg     1260

ggttagaaga cataaaccaa gtctgcccag ttcccttccc aatcctacaa aggagccttc     1320

ctcccagaac ctgtggtccc tgattctgga gggggaactt cttgcttctc attttgctaa     1380

ggaagtttat tttggtgaag ttgttcccat tctgagcccc gggactctta ttctgatgat     1440

gtgtcacccc acattggcac ctcctactac caccacacaa acttagttca tatgctctta     1500

cttgggcaag ggtgctttcc ttccaatacc ccagtagctt ttattttagt aaagggaccc     1560

tttcccctag cctagggtcc catattgggt caagctgctt acctgcctca gcccaggatt     1620

ctttattctg ggggaggtaa tgccctgttg ttaccccaag gcttcttttt tttttttttt     1680

tgggtgaggg gaccctactc tgttatccca agtgctctta ttctggtgag aagaacctta     1740

cttccataat ttgggaagga atggaagatg gacaccaccg gacaccacca gacactagga     1800

tgggatggat ggttttttgg gggatgggct aggggaaata aggcttgctg tttgttctcc     1860

tggggcgctc cctccaactt ttgcagattc ttgcaacctc ctcctgagcc gggattgtcc     1920

aattactaaa atgtaaataa tcacgtattg tggggagggg agttccaagt gtgccctcct     1980

ctcttctcct gcctggatta tttaaaaagc catgtgtgga aacccactat ttaataaaag     2040

taatagaatc agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

a                                                                     2101


<210>  17
<211>  3001
<212>  DNA
<213>  Homo sapiens

<400>  17
aatcttataa cttgaagaac tgccctggag aaaggaagaa acttataata aatgggaaat       60

tataaatcta gaccaaccca aacttgtact gatgaatgga agaaaaaagt cagtgaatca      120

tatgttatca caatagaaag attagaagat gacctgcaga tcaaggaaaa agaactgaca      180

gaactaagga atatatttgg ctctgatgaa gccttcagta aagtcaattt aaattaccgc      240

actgaaaatg ggctgtctct acttcattta tgttgcattt gtggaggcaa gaaatcacat      300

attcgaactc ttatgttgaa agggctccgc ccatctcgac tgacaagaaa tggatttaca      360

gccttgcatt tagcagttta caaggataat gcagaattga tcacttctct gcttcacagt      420

ggagctgata tacagcaggt tggatacggt ggcctcactg ccctccatat tgctacaata      480

gctggccacc tagaggctgc tgatgtgctg ttgcaacatg gagctaatgt caatattcaa      540

gatgcagttt ttttcactcc attgcatatt gcagcgtact atggacatga acaggtaact      600

cgccttcttt tgaaatttgg tgctgatgta aatgtaagtg gtgaagttgg agatagaccc      660

ctccacctag catctgcaaa aggattcttg aatattgcaa aactcttgat ggaagaaggc      720

agcaaagcag atgtgaatgc tcaagataat gaagaccatg tcccactcca tttctgttct      780

cgatttggac accatgatat agttaagtat ctgctgcaaa gtgatttgga agttcaacct      840

catgttgtta atatctatgg agataccccc ttacacctgg catgctacaa tggcaaattt      900

gaagttgcca aggaaatcat ccaaatatca ggaacagaaa gtctgactaa ggaaaacatc      960

ttcagtgaaa cagcttttca tagtgcttgt acctatggca agagcattga cctagtcaaa     1020

tttcttcttg atcagaatgt cataaacatc aaccaccaag gaagggatgg gcacactgga     1080

ttacactctg cttgctacca cggtcacatt cgcctggttc agttcttact ggataatgga     1140

gctgatatga atctagtggc ttgtgatccc agcaggtcta gtggtgaaaa agatgagcag     1200

acatgtttga tgtgggctta tgaaaaaggg catgatgcca ttgtcacact cctgaagcat     1260

tataagagac cacaagatga attgccctgt aatgaatatt ctcagcctgg aggagatggc     1320

tcctatgtgt ctgttccatc acccttgggg aagattaaaa gcatgacaaa agagaaggca     1380

gatattctcc tcctaagagc tggattgcct tcacatttcc atcttcagct ctcagaaatt     1440

gagttccatg agattattgg ctcaggttct tttgggaaag tatataaagg acgatgcaga     1500

aataaaatag tggctataaa acgttatcga gccaatacct actgctccaa gtcagatgtg     1560

gatatgtttt gccgagaggt gtccattctc tgccagctca atcatccctg cgtaattcag     1620

tttgtgggtg cttgcttgaa tgatcccagc cagtttgcca ttgtcactca atacatatca     1680

gggggttctc tgttctccct ccttcatgag cagaagagga ttcttgattt gcagtctaaa     1740

ttaattattg cagtagatgt tgccaaaggc atggagtacc ttcacaacct gacacagcca     1800

attatacatc gtgacttgaa cagtcacaat attcttctct atgaggatgg gcatgctgtg     1860

gtggcagatt ttggagaatc aagatttcta cagtctctgg atgaagacaa catgacaaaa     1920

caacctggga acctccgttg gatggctcct gaggtgttca cgcagtgcac tcggtacacc     1980

atcaaagcag atgtcttcag ctatgctctg tgtctgtggg aaattctcac tggcgaaatt     2040

ccattcgctc atctcaagcc agcggctgcg gcagcagaca tggcttacca ccacatcaga     2100

cctcccattg gctattccat tcccaagccc atatcatctc tgctgatacg agggtggaac     2160

gcatgtcctg aaggaagacc cgaattttct gaagttgtca tgaagttaga agagtgtctc     2220

tgcaacattg agctgatgtc tcctgcatca agtaacagca gtgggtctct ctcaccttct     2280

tcttcttctg attgcctggt gaaccgggga ggacctggcc ggagtcatgt ggcagcatta     2340

agaagtcgtt tcgaattgga atatgctcta aatgcaaggt cctatgctgc tttgtcccaa     2400

agtgctggac aatattcctc tcaaggtctg tctttggagg agatgaaaag aagtcttcaa     2460

tacacaccca ttgacaaata tggctatgta tccgatccca tgagctcaat gcattttcat     2520

tcttgccgaa atagtagcag ctttgaggac agcagctgac agcattcggc gtatacctaa     2580

ggagagtttt ttccccgaac tgacagcaac gattccaacc acggcaagct ggcttccaac     2640

tataacattt tactctcaaa ggtctcctta aattgggctt gtttttactt gtcctattta     2700

attccccact attagcaggc tttggatttg tgcctaagga ataatatgca aaagaaccaa     2760

gacagaatgt atatgaagaa ttgtttttaa ttttgtaaat taaaaaaaaa tttagatcgt     2820

tacttggaaa tggagcctaa gtctgtggtg gacagataat aattatgttt tcctgggctg     2880

aattatgtag acttgtgttt gacagctatg ggtttatttc ttagaacatt gttcattttc     2940

ttttctcatt atgttacttc tagtgttcac ctctgtgatt aaagattctt tggtgaaata     3000

g                                                                     3001


<210>  18
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  18
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaaggtaac     1620

aacaaagagc aaatccatcc ccacaccctg ttcactcctt tgctgattgg tttcgtaatc     1680

gtagctggca tgatgtgcat tattgtgatg attctgacct acaaatattt acagaaaccc     1740

atgtatgaag tacagtggaa ggttgttgag gagataaatg gaaacaatta tgtttacata     1800

gacccaacac aacttcctta tgatcacaaa tgggagtttc ccagaaacag gctgagtttt     1860

gggaaaaccc tgggtgctgg agctttcggg aaggttgttg aggcaactgc ttatggctta     1920

attaagtcag atgcggccat gactgtcgct gtaaagatgc tcaagccgag tgcccatttg     1980

acagaacggg aagccctcat gtctgaactc aaagtcctga gttaccttgg taatcacatg     2040

aatattgtga atctacttgg agcctgcacc attggagggc ccaccctggt cattacagaa     2100

tattgttgct atggtgatct tttgaatttt ttgagaagaa aacgtgattc atttatttgt     2160

tcaaagcagg aagatcatgc agaagctgca ctttataaga atcttctgca ttcaaaggag     2220

tcttcctgca gcgatagtac taatgagtac atggacatga aacctggagt ttcttatgtt     2280

gtcccaacca aggccgacaa aaggagatct gtgagaatag gctcatacat agaaagagat     2340

gtgactcccg ccatcatgga ggatgacgag ttggccctag acttagaaga cttgctgagc     2400

ttttcttacc aggtggcaaa gggcatggct ttcctcgcct ccaagaattg tattcacaga     2460

gacttggcag ccagaaatat cctccttact catggtcgga tcacaaagat ttgtgatttt     2520

ggtctagcca gagacatcaa gaatgattct aattatgtgg ttaaaggaaa cgctcgacta     2580

cctgtgaagt ggatggcacc tgaaagcatt ttcaactgtg tatacacgtt tgaaagtgac     2640

gtctggtcct atgggatttt tctttgggag ctgttctctt taggaagcag cccctatcct     2700

ggaatgccgg tcgattctaa gttctacaag atgatcaagg aaggcttccg gatgctcagc     2760

cctgaacacg cacctgctga aatgtatgac ataatgaaga cttgctggga tgcagatccc     2820

ctaaaaagac caacattcaa gcaaattgtt cagctaattg agaagcagat ttcagagagc     2880

accaatcata tttactccaa cttagcaaac tgcagcccca accgacagaa gcccgtggta     2940

gaccattctg tgcggatcaa ttctgtcggc agcaccgctt cctcctccca gcctctgctt     3000

gtgcacgacg atgtctgagc agaatcagtg tttgggtcac ccctccagga atgatctctt     3060

cttttggctt ccatgatggt tattttcttt tctttcaact tgcatccaac tccaggatag     3120

tgggcacccc actgcaatcc tgtctttctg agcacacttt agtggccgat gatttttgtc     3180

atcagccacc atcctattgc aaaggttcca actgtatata ttcccaatag caacgtagct     3240

tctaccatga acagaaaaca ttctgatttg gaaaaagaga gggaggtatg gactgggggc     3300

cagagtcctt tccaaggctt ctccaattct gcccaaaaat atggttgata gtttacctga     3360

ataaatggta gtaatcacag ttggccttca gaaccatcca tagtagtatg atgatacaag     3420

attagaagct gaaaacctaa gtcctttatg tggaaaacag aacatcatta gaacaaagga     3480

cagagtatga acacctgggc ttaagaaatc tagtatttca tgctgggaat gagacatagg     3540

ccatgaaaaa aatgatcccc aagtgtgaac aaaagatgct cttctgtgga ccactgcatg     3600

agcttttata ctaccgacct ggtttttaaa tagagtttgc tattagagca ttgaattgga     3660

gagaaggcct ccctagccag cacttgtata tacgcatcta taaattgtcc gtgttcatac     3720

atttgagggg aaaacaccat aaggtttcgt ttctgtatac aaccctggca ttatgtccac     3780

tgtgtataga agtagattaa gagccatata agtttgaagg aaacagttaa taccattttt     3840

taaggaaaca atataaccac aaagcacagt ttgaacaaaa tctcctcttt tagctgatga     3900

acttattctg tagattctgt ggaacaagcc tatcagcttc agaatggcat tgtactcaat     3960

ggatttgatg ctgtttgaca aagttactga ttcactgcat ggctcccaca ggagtgggaa     4020

aacactgcca tcttagtttg gattcttatg tagcaggaaa taaagtatag gtttagcctc     4080

cttcgcaggc atgtcctgga caccgggcca gtatctatat atgtgtatgt acgtttgtat     4140

gtgtgtagac aaatatttgg aggggtattt ttgccctgag tccaagaggg tcctttagta     4200

cctgaaaagt aacttggctt tcattattag tactgctctt gtttcttttc acatagctgt     4260

ctagagtagc ttaccagaag cttccatagt ggtgcagagg aagtggaagg catcagtccc     4320

tatgtatttg cagttcacct gcacttaagg cactctgtta tttagactca tcttactgta     4380

cctgttcctt agaccttcca taatgctact gtctcactga aacatttaaa ttttaccctt     4440

tagactgtag cctggatatt attcttgtag tttacctctt taaaaacaaa acaaaacaaa     4500

acaaaaaact ccccttcctc actgcccaat ataaaaggca aatgtgtaca tggcagagtt     4560

tgtgtgttgt cttgaaagat tcaggtatgt tgcctttatg gtttccccct tctacatttc     4620

ttagactaca tttagagaac tgtggccgtt atctggaagt aaccatttgc actggagttc     4680

tatgctctcg cacctttcca aagttaacag attttggggt tgtgttgtca cccaagagat     4740

tgttgtttgc catactttgt ctgaaaaatt cctttgtgtt tctattgact tcaatgatag     4800

taagaaaagt ggttgttagt tatagatgtc taggtacttc aggggcactt cattgagagt     4860

tttgtcttgg atattcttga aagtttatat ttttataatt ttttcttaca tcagatgttt     4920

ctttgcagtg gcttaatgtt tgaaattatt ttgtggcttt ttttgtaaat attgaaatgt     4980

agcaataatg tcttttgaat attcccaagc ccatgagtcc ttgaaaatat tttttatata     5040

tacagtaact ttatgtgtaa atacataagc ggcgtaagtt taaaggatgt tggtgttcca     5100

cgtgttttat tcctgtatgt tgtccaattg ttgacagttc tgaagaattc taataaaatg     5160

tacatatata aatcaaaaaa aaaaaaaaaa                                      5190


<210>  19
<211>  2501
<212>  DNA
<213>  Homo sapiens

<400>  19
cgaaaagatt cttaggaacg ccgtaccagc cgcgtctctc aggacagcag gcccctgtcc       60

ttctgtcggg cgccgctcag ccgtgccctc cgcccctcag gttctttttc taattccaaa      120

taaacttgca agaggactat gaaagattat gatgaacttc tcaaatatta tgaattacat      180

gaaactattg ggacaggtgg ctttgcaaag gtcaaacttg cctgccatat ccttactgga      240

gagatggtag ctataaaaat catggataaa aacacactag ggagtgattt gccccggatc      300

aaaacggaga ttgaggcctt gaagaacctg agacatcagc atatatgtca actctaccat      360

gtgctagaga cagccaacaa aatattcatg gttcttgagt actgccctgg aggagagctg      420

tttgactata taatttccca ggatcgcctg tcagaagagg agacccgggt tgtcttccgt      480

cagatagtat ctgctgttgc ttatgtgcac agccagggct atgctcacag ggacctcaag      540

ccagaaaatt tgctgtttga tgaatatcat aaattaaagc tgattgactt tggtctctgt      600

gcaaaaccca agggtaacaa ggattaccat ctacagacat gctgtgggag tctggcttat      660

gcagcacctg agttaataca aggcaaatca tatcttggat cagaggcaga tgtttggagc      720

atgggcatac tgttatatgt tcttatgtgt ggatttctac catttgatga tgataatgta      780

atggctttat acaagaagat tatgagagga aaatatgatg ttcccaagtg gctctctccc      840

agtagcattc tgcttcttca acaaatgctg caggtggacc caaagaaacg gatttctatg      900

aaaaatctat tgaaccatcc ctggatcatg caagattaca actatcctgt tgagtggcaa      960

agcaagaatc cttttattca cctcgatgat gattgcgtaa cagaactttc tgtacatcac     1020

agaaacaaca ggcaaacaat ggaggattta atttcactgt ggcagtatga tcacctcacg     1080

gctacctatc ttctgcttct agccaagaag gctcggggaa aaccagttcg tttaaggctt     1140

tcttctttct cctgtggaca agccagtgct accccattca cagacatcaa gtcaaataat     1200

tggagtctgg aagatgtgac cgcaagtgat aaaaattatg tggcgggatt aatagactat     1260

gattggtgtg aagatgattt atcaacaggt gctgctactc cccgaacatc acagtttacc     1320

aagtactgga cagaatcaaa tggggtggaa tctaaatcat taactccagc cttatgcaga     1380

acacctgcaa ataaattaaa gaacaaagaa aatgtatata ctcctaagtc tgctgtaaag     1440

aatgaagagt actttatgtt tcctgagcca aagactccag ttaataagaa ccagcataag     1500

agagaaatac tcactacgcc aaatcgttac actacaccct caaaagctag aaaccagtgc     1560

ctgaaagaaa ctccaattaa aataccagta aattcaacag gaacagacaa gttaatgaca     1620

ggtgtcatta gccctgagag gcggtgccgc tcagtggaat tggatctcaa ccaagcacat     1680

atggaggaga ctccaaaaag aaagggagcc aaagtgtttg ggagccttga aagggggttg     1740

gataaggtta tcactgtgct caccaggagc aaaaggaagg gttctgccag agacgggccc     1800

agaagactaa agcttcacta taatgtgact acaactagat tagtgaatcc agatcaactg     1860

ttgaatgaaa taatgtctat tcttccaaag aagcatgttg actttgtaca aaagggttat     1920

acactgaagt gtcaaacaca gtcagatttt gggaaagtga caatgcaatt tgaattagaa     1980

gtgtgccagc ttcaaaaacc cgatgtggtg ggtatcagga ggcagcggct taagggcgat     2040

gcctgggttt acaaaagatt agtggaagac atcctatcta gctgcaaggt ataattgatg     2100

gattcttcca tcctgccgga tgagtgtggg tgtgatacag cctacataaa gactgttatg     2160

atcgctttga ttttaaagtt cattggaact accaacttgt ttctaaagag ctatcttaag     2220

accaatatct ctttgttttt aaacaaaaga tattattttg tgtatgaatc taaatcaagc     2280

ccatctgtca ttatgttact gtctttttta atcatgtggt tttgtatatt aataattgtt     2340

gactttctta gattcacttc catatgtgaa tgtaagctct taactatgtc tctttgtaat     2400

gtgtaatttc tttctgaaat aaaaccattt gtgaatataa aaaaaaaaaa aaaaaaaaaa     2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2501


<210>  20
<211>  2346
<212>  DNA
<213>  Homo sapiens

<400>  20
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct       60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg      120

ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag      180

gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc      240

ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc      300

ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gaggcatcat      360

ggaccgatct aaagaaaact gcatttcagg acctgttaag gctacagctc cagttggagg      420

tccaaaacgt gttctcgtga ctcagcaatt tccttgtcag aatccattac ctgtaaatag      480

tggccaggct cagcgggtct tgtgtccttc aaattcttcc cagcgcattc ctttgcaagc      540

acaaaagctt gtctccagtc acaagccggt tcagaatcag aagcagaagc aattgcaggc      600

aaccagtgta cctcatcctg tctccaggcc actgaataac acccaaaaga gcaagcagcc      660

cctgccatcg gcacctgaaa ataatcctga ggaggaactg gcatcaaaac agaaaaatga      720

agaatcaaaa aagaggcagt gggctttgga agactttgaa attggtcgcc ctctgggtaa      780

aggaaagttt ggtaatgttt atttggcaag agaaaagcaa agcaagttta ttctggctct      840

taaagtgtta tttaaagctc agctggagaa agccggagtg gagcatcagc tcagaagaga      900

agtagaaata cagtcccacc ttcggcatcc taatattctt agactgtatg gttatttcca      960

tgatgctacc agagtctacc taattctgga atatgcacca cttggaacag tttatagaga     1020

acttcagaaa ctttcaaagt ttgatgagca gagaactgct acttatataa cagaattggc     1080

aaatgccctg tcttactgtc attcgaagag agttattcat agagacatta agccagagaa     1140

cttacttctt ggatcagctg gagagcttaa aattgcagat tttgggtggt cagtacatgc     1200

tccatcttcc aggaggacca ctctctgtgg caccctggac tacctgcccc ctgaaatgat     1260

tgaaggtcgg atgcatgatg agaaggtgga tctctggagc cttggagttc tttgctatga     1320

atttttagtt gggaagcctc cttttgaggc aaacacatac caagagacct acaaaagaat     1380

atcacgggtt gaattcacat tccctgactt tgtaacagag ggagccaggg acctcatttc     1440

aagactgttg aagcataatc ccagccagag gccaatgctc agagaagtac ttgaacaccc     1500

ctggatcaca gcaaattcat caaaaccatc aaattgccaa aacaaagaat cagctagcaa     1560

acagtcttag gaatcgtgca gggggagaaa tccttgagcc agggctgcca tataacctga     1620

caggaacatg ctactgaagt ttattttacc attgactgct gccctcaatc tagaacgcta     1680

cacaagaaat atttgtttta ctcagcaggt gtgccttaac ctccctattc agaaagctcc     1740

acatcaataa acatgacact ctgaagtgaa agtagccacg agaattgtgc tacttatact     1800

ggttcataat ctggaggcaa ggttcgactg cagccgcccc gtcagcctgt gctaggcatg     1860

gtgtcttcac aggaggcaaa tccagagcct ggctgtgggg aaagtgacca ctctgccctg     1920

accccgatca gttaaggagc tgtgcaataa ccttcctagt acctgagtga gtgtgtaact     1980

tattgggttg gcgaagcctg gtaaagctgt tggaatgagt atgtgattct ttttaagtat     2040

gaaaataaag atatatgtac agacttgtat tttttctctg gtggcattcc tttaggaatg     2100

ctgtgtgtct gtccggcacc ccggtaggcc tgattgggtt tctagtcctc cttaaccact     2160

tatctcccat atgagagtgt gaaaaatagg aacacgtgct ctacctccat ttagggattt     2220

gcttgggata cagaagaggc catgtgtctc agagctgtta agggcttatt tttttaaaac     2280

attggagtca tagcatgtgt gtaaacttta aatatgcaaa taaataagta tctatgtcta     2340

aaaaaa                                                                2346


<210>  21
<211>  2346
<212>  DNA
<213>  Homo sapiens

<400>  21
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct       60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg      120

ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag      180

gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc      240

ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc      300

ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gaggcatcat      360

ggaccgatct aaagaaaact gcatttcagg acctgttaag gctacagctc cagttggagg      420

tccaaaacgt gttctcgtga ctcagcaatt tccttgtcag aatccattac ctgtaaatag      480

tggccaggct cagcgggtct tgtgtccttc aaattcttcc cagcgcattc ctttgcaagc      540

acaaaagctt gtctccagtc acaagccggt tcagaatcag aagcagaagc aattgcaggc      600

aaccagtgta cctcatcctg tctccaggcc actgaataac acccaaaaga gcaagcagcc      660

cctgccatcg gcacctgaaa ataatcctga ggaggaactg gcatcaaaac agaaaaatga      720

agaatcaaaa aagaggcagt gggctttgga agactttgaa attggtcgcc ctctgggtaa      780

aggaaagttt ggtaatgttt atttggcaag agaaaagcaa agcaagttta ttctggctct      840

taaagtgtta tttaaagctc agctggagaa agccggagtg gagcatcagc tcagaagaga      900

agtagaaata cagtcccacc ttcggcatcc taatattctt agactgtatg gttatttcca      960

tgatgctacc agagtctacc taattctgga atatgcacca cttggaacag tttatagaga     1020

acttcagaaa ctttcaaagt ttgatgagca gagaactgct acttatataa cagaattggc     1080

aaatgccctg tcttactgtc attcgaagag agttattcat agagacatta agccagagaa     1140

cttacttctt ggatcagctg gagagcttaa aattgcagat tttgggtggt cagtacatgc     1200

tccatcttcc aggaggacca ctctctgtgg caccctggac tacctgcccc ctgaaatgat     1260

tgaaggtcgg atgcatgatg agaaggtgga tctctggagc cttggagttc tttgctatga     1320

atttttagtt gggaagcctc cttttgaggc aaacacatac caagagacct acaaaagaat     1380

atcacgggtt gaattcacat tccctgactt tgtaacagag ggagccaggg acctcatttc     1440

aagactgttg aagcataatc ccagccagag gccaatgctc agagaagtac ttgaacaccc     1500

ctggatcaca gcaaattcat caaaaccatc aaattgccaa aacaaagaat cagctagcaa     1560

acagtcttag gaatcgtgca gggggagaaa tccttgagcc agggctgcca tataacctga     1620

caggaacatg ctactgaagt ttattttacc attgactgct gccctcaatc tagaacgcta     1680

cacaagaaat atttgtttta ctcagcaggt gtgccttaac ctccctattc agaaagctcc     1740

acatcaataa acatgacact ctgaagtgaa agtagccacg agaattgtgc tacttatact     1800

ggttcataat ctggaggcaa ggttcgactg cagccgcccc gtcagcctgt gctaggcatg     1860

gtgtcttcac aggaggcaaa tccagagcct ggctgtgggg aaagtgacca ctctgccctg     1920

accccgatca gttaaggagc tgtgcaataa ccttcctagt acctgagtga gtgtgtaact     1980

tattgggttg gcgaagcctg gtaaagctgt tggaatgagt atgtgattct ttttaagtat     2040

gaaaataaag atatatgtac agacttgtat tttttctctg gtggcattcc tttaggaatg     2100

ctgtgtgtct gtccggcacc ccggtaggcc tgattgggtt tctagtcctc cttaaccact     2160

tatctcccat atgagagtgt gaaaaatagg aacacgtgct ctacctccat ttagggattt     2220

gcttgggata cagaagaggc catgtgtctc agagctgtta agggcttatt tttttaaaac     2280

attggagtca tagcatgtgt gtaaacttta aatatgcaaa taaataagta tctatgtcta     2340

aaaaaa                                                                2346


<210>  22
<211>  3229
<212>  DNA
<213>  Homo sapiens

<400>  22
gatcagctgg cgggcgggcg ggagccgagc gcggccccgg ctctcgctgc agcgccgcct       60

cttctctgcg tcgcaggccg gcccggcggc cgtgacaatg tcgcggggct ggtagcaggg      120

cgccggccgc cgagccgtct caagtttaaa cttacacgaa tcgctttctg gaggaggagg      180

ggacccgctg cgcgattgac acgcatattc ctataggcat cctccctcag cccccacccc      240

cacggccgga ttcgggtggc tcctctccga ggtgaaatct gagaagaaat ccttggatct      300

cttttcttaa aaaaaaaaaa aaaaaaaaaa aatctagaaa ccatcggtat tttgctttgc      360

tgctccctat tcgcaagatg aagaagtttt tcgactcccg gcgagagcag ggcggctctg      420

gcctgggctc cggctccagc ggaggagggg gcagcacctc gggcctgggc agtggctaca      480

tcggaagagt cttcggcatc gggcgacagc aggtcacagt ggacgaggtg ttggcggaag      540

gtggatttgc tattgtattt ctggtgagga caagcaatgg gatgaaatgt gccttgaaac      600

gcatgtttgt caacaatgag catgatctcc aggtgtgcaa gagagaaatc cagataatga      660

gggatctttc agggcacaag aatattgtgg gttacattga ttctagtatc aacaacgtga      720

gtagcggtga tgtatgggaa gtgctcattc tgatggactt ttgtagaggt ggccaggtgg      780

taaacctgat gaaccagcgc ctgcaaacag gctttacaga gaatgaagtg ctccagatat      840

tttgtgatac ctgtgaagct gttgcccgcc tgcatcagtg caaaactcct attatccacc      900

gggacctgaa ggttgaaaac atcctcttgc atgaccgagg ccactatgtc ctgtgtgact      960

ttggaagcgc caccaacaaa ttccagaatc cacaaactga gggagtcaat gcagtagaag     1020

atgagattaa gaaatacaca acgctgtcct atcgagcacc agaaatggtc aacctgtaca     1080

gtggcaaaat catcactacg aaggcagaca tttgggctct tggatgtttg ttgtataaat     1140

tatgctactt cactttgcca tttggggaaa gtcaggtggc aatttgtgat ggaaacttca     1200

caattcctga taattctcga tattctcaag acatgcactg cctaattagg tatatgttgg     1260

aaccagaccc tgacaaaagg ccggatattt accaggtgtc ctacttctca tttaagctac     1320

tcaagaaaga gtgcccaatt ccaaatgtac agaactctcc cattcctgca aagcttcctg     1380

aaccagtgaa agccagtgag gcagctgcaa aaaagaccca gccaaaggcc agactgacag     1440

atcccattcc caccacagag acttcaattg caccccgcca gaggcctaaa gctgggcaga     1500

ctcagccgaa cccaggaatc cttcccatcc agccagcgct gacaccccgg aagagggcca     1560

ctgttcagcc cccacctcag gctgcaggat ccagcaatca gcctggcctt ttagccagtg     1620

ttccccaacc aaaaccccaa gccccaccca gccagcctct gccgcaaact caggccaagc     1680

agccacaggc tcctcccact ccacagcaga cgccttctac tcaggcccag ggtctgcccg     1740

ctcaggccca ggccacaccc cagcaccagc agcaactctt cctcaagcag caacagcagc     1800

agcaacagcc accgccagca cagcagcagc cggcaggcac gttttaccag cagcagcagg     1860

cccagactca gcagtttcag gcagtacatc cagcaaccca gaaaccagca attgctcagt     1920

tccctgtggt gtcccaagga ggctctcaac agcagctaat gcagaatttc taccagcagc     1980

agcagcagca gcaacaacaa cagcaacagc aacagctggc cacagccctg catcaacaac     2040

agctgatgac tcagcaggct gccttgcagc aaaagcccac tatggcagca ggacagcagc     2100

cccagccaca gccagctgca gccccacagc cagcccctgc ccaggagcca gcgattcaag     2160

ccccagtaag acaacagcca aaggttcaga caaccccacc tcctgccgtc caggggcaga     2220

aagttggatc tctcactcca ccctcatccc ccaaaaccca acgtgctggg cacaggcgta     2280

ttctcagtga cgtaacccac agtgcagtct ttggggtccc tgccagcaaa tcaacccagc     2340

tgctccaggc agctgcagct gaggccagtc tcaataagtc caagtctgca accaccactc     2400

catcaggctc tcctcggacc tctcaacaaa acgtttataa tccttcagaa gggtctacgt     2460

ggaatccctt tgatgacgat aatttctcca aactcacagc tgaagaactg ctaaacaagg     2520

actttgccaa gcttggggaa ggcaaacatc ccgagaagct tggaggctca gctgagagtt     2580

tgatcccagg ctttcaatca acccaaggtg atgcttttgc tacgacctca ttttctgctg     2640

gaactgctga aaaaaggaag ggtgggcaga ctgtggactc tggcctcccg cttctaagcg     2700

tgtctgatcc tttcattcct cttcaagtac ctgatgcacc agaaaaacta attgagggac     2760

tcaaatctcc tgacacttct cttctgctcc ctgacctctt gcctatgaca gatccttttg     2820

gtagcacttc tgatgctgta attggtaaag tcatcatctc tgtttcttca gtcatgcatg     2880

atatgtgtgc ctgtttcaag aatgacaagt acctagttaa ccaatccctg gggaatagcc     2940

ctgccacccc agaagccaag gctatttaat ctcacttgta tcactccaaa tgaagtgttt     3000

tccttgcttt tcgggggtac aacgtctatt ttttgccttt cttgatatct ggagatttct     3060

agagtggatc tcttatgaat gaggaggaat gtggaaagtt tcacatttag ttagaagaac     3120

tttaaaaaat tggtttctaa ctagactacc tttactgaac ttaatgaaat ttagcagatt     3180

cttctttttt ttttttttgt ttgagacaga gtttcactct tgttgcctg                 3229


<210>  23
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Lys Glu Pro Leu Thr Leu Lys Ser Ile Gln Val Ala Val Glu 
1               5                   10                  15      


Glu Leu Tyr Pro Asn Lys Ala Arg Ala Leu Thr Leu Ala Gln His Ser 
            20                  25                  30          


Arg Ala Pro Ser Pro Arg Leu Arg Ser Arg Leu Phe Ser Lys Ala Leu 
        35                  40                  45              


Lys Gly Asp His Arg Cys Gly Glu Thr Glu Thr Pro Lys Ser Cys Ser 
    50                  55                  60                  


Glu Val Ala Gly Cys Lys Ala Ala Met Arg His Gln Gly Lys Ile Pro 
65                  70                  75                  80  


Glu Glu Leu Ser Leu Asp Asp Arg Ala Arg Thr Gln Lys Lys Trp Gly 
                85                  90                  95      


Arg Gly Lys Trp Glu Pro Glu Pro Ser Ser Lys Pro Pro Arg Glu Ala 
            100                 105                 110         


Thr Leu Glu Glu Arg His Ala Arg Gly Glu Lys His Leu Gly Val Glu 
        115                 120                 125             


Ile Glu Lys Thr Ser Gly Glu Ile Ile Arg Cys Glu Lys Cys Lys Arg 
    130                 135                 140                 


Glu Arg Glu Leu Gln Gln Ser Leu Glu Arg Glu Arg Leu Ser Leu Gly 
145                 150                 155                 160 


Thr Ser Glu Leu Asp Met Gly Lys Gly Pro Met Tyr Asp Val Glu Lys 
                165                 170                 175     


Leu Val Arg Thr Arg Ser Cys Arg Arg Ser Pro Glu Ala Asn Pro Ala 
            180                 185                 190         


Ser Gly Glu Glu Gly Trp Lys Gly Asp Ser His Arg Ser Ser Pro Arg 
        195                 200                 205             


Asn Pro Thr Gln Glu Leu Arg Arg Pro Ser Lys Ser Met Asp Lys Lys 
    210                 215                 220                 


Glu Asp Arg Gly Pro Glu Asp Gln Glu Ser His Ala Gln Gly Ala Ala 
225                 230                 235                 240 


Lys Ala Lys Lys Asp Leu Val Glu Val Leu Pro Val Thr Glu Glu Gly 
                245                 250                 255     


Leu Arg Glu Val Lys Lys Asp Thr Arg Pro Met Ser Arg Ser Lys His 
            260                 265                 270         


Gly Gly Trp Leu Leu Arg Glu His Gln Ala Gly Phe Glu Lys Leu Arg 
        275                 280                 285             


Arg Thr Arg Gly Glu Glu Lys Glu Ala Glu Lys Glu Lys Lys Pro Cys 
    290                 295                 300                 


Met Ser Gly Gly Arg Arg Met Thr Leu Arg Asp Asp Gln Pro Ala Lys 
305                 310                 315                 320 


Leu Glu Lys Glu Pro Lys Thr Arg Pro Glu Glu Asn Lys Pro Glu Arg 
                325                 330                 335     


Pro Ser Gly Arg Lys Pro Arg Pro Met Gly Ile Ile Ala Ala Asn Val 
            340                 345                 350         


Glu Lys His Tyr Glu Thr Gly Arg Val Ile Gly Asp Gly Asn Phe Ala 
        355                 360                 365             


Val Val Lys Glu Cys Arg His Arg Glu Thr Arg Gln Ala Tyr Ala Met 
    370                 375                 380                 


Lys Ile Ile Asp Lys Ser Arg Leu Lys Gly Lys Glu Asp Met Val Asp 
385                 390                 395                 400 


Ser Glu Ile Leu Ile Ile Gln Ser Leu Ser His Pro Asn Ile Val Lys 
                405                 410                 415     


Leu His Glu Val Tyr Glu Thr Asp Met Glu Ile Tyr Leu Ile Leu Glu 
            420                 425                 430         


Tyr Val Gln Gly Gly Asp Leu Phe Asp Ala Ile Ile Glu Ser Val Lys 
        435                 440                 445             


Phe Pro Glu Pro Asp Ala Ala Leu Met Ile Met Asp Leu Cys Lys Ala 
    450                 455                 460                 


Leu Val His Met His Asp Lys Ser Ile Val His Arg Asp Leu Lys Pro 
465                 470                 475                 480 


Glu Asn Leu Leu Val Gln Arg Asn Glu Asp Lys Ser Thr Thr Leu Lys 
                485                 490                 495     


Leu Ala Asp Phe Gly Leu Ala Lys His Val Val Arg Pro Ile Phe Thr 
            500                 505                 510         


Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Leu Ser Glu Lys 
        515                 520                 525             


Gly Tyr Gly Leu Glu Val Asp Met Trp Ala Ala Gly Val Ile Leu Tyr 
    530                 535                 540                 


Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Ser Pro Glu Arg Asp Gln 
545                 550                 555                 560 


Asp Glu Leu Phe Asn Ile Ile Gln Leu Gly His Phe Glu Phe Leu Pro 
                565                 570                 575     


Pro Tyr Trp Asp Asn Ile Ser Asp Ala Ala Lys Asp Leu Val Ser Arg 
            580                 585                 590         


Leu Leu Val Val Asp Pro Lys Lys Arg Tyr Thr Ala His Gln Val Leu 
        595                 600                 605             


Gln His Pro Trp Ile Glu Thr Ala Gly Lys Thr Asn Thr Val Lys Arg 
    610                 615                 620                 


Gln Lys Gln Val Ser Pro Ser Ser Glu Gly His Phe Arg Ser Gln His 
625                 630                 635                 640 


Lys Arg Val Val Glu Gln Val Ser 
                645             


<210>  24
<211>  3332
<212>  DNA
<213>  Homo sapiens

<400>  24
gcgccgagcc ggtttccccg ccggtgtccg agaggcgccc ccggcccggc ccggcccggc       60

ccgcgccctc cgcccccgcc tccccgggcc ggcggcggtg ggcgagctcg cgggcccggc      120

cgcccccagc cccagccccg ccgggccccg ccccccgtcg agtgcatgag gttgacgcta      180

ctttgttgca cctggaggga agaacgtatg ggagaggaag gaagcgagtt gcccgtgtgt      240

gcaagctgcg gccagaggat ctatgatggc cagtacctcc aggccctgaa cgcggactgg      300

cacgcagact gcttcaggtg ttgtgactgc agtgcctccc tgtcgcacca gtactatgag      360

aaggatgggc agctcttctg caagaaggac tactgggccc gctatggcga gtcctgccat      420

gggtgctctg agcaaatcac caagggactg gttatggtgg ctggggagct gaagtaccac      480

cccgagtgtt tcatctgcct cacgtgtggg acctttatcg gtgacgggga cacctacacg      540

ctggtggagc actccaagct gtactgcggg cactgctact accagactgt ggtgaccccc      600

gtcatcgagc agatcctgcc tgactcccct ggctcccacc tgccccacac cgtcaccctg      660

gtgtccatcc cagcctcatc tcatggcaag cgtggacttt cagtctccat tgaccccccg      720

cacggcccac cgggctgtgg caccgagcac tcacacaccg tccgcgtcca gggagtggat      780

ccgggctgca tgagcccaga tgtgaagaat tccatccacg tcggagaccg gatcttggaa      840

atcaatggca cgcccatccg aaatgtgccc ctggacgaga ttgacctgct gattcaggaa      900

accagccgcc tgctccagct gaccctcgag catgaccctc acgatacact gggccacggg      960

ctggggcctg agaccagccc cctgagctct ccggcttata ctcccagcgg ggaggcgggc     1020

agctctgccc ggcagaaacc tgtcttgagg agctgcagca tcgacaggtc tccgggcgct     1080

ggctcactgg gctccccggc ctcccagcgc aaggacctgg gtcgctctga gtccctccgc     1140

gtagtctgcc ggccacaccg catcttccgg ccgtcggacc tcatccacgg ggaggtgctg     1200

ggcaagggct gcttcggcca ggctatcaag gtgacacacc gtgagacagg tgaggtgatg     1260

gtgatgaagg agctgatccg gttcgacgag gagacccaga ggacgttcct caaggaggtg     1320

aaggtcatgc gatgcctgga acaccccaac gtgctcaagt tcatcggggt gctctacaag     1380

gacaagaggc tcaacttcat cactgagtac atcaagggcg gcacgctccg gggcatcatc     1440

aagagcatgg acagccagta cccatggagc cagagagtga gctttgccaa ggacatcgca     1500

tcagggatgg cctacctcca ctccatgaac atcatccacc gagacctcaa ctcccacaac     1560

tgcctggtcc gcgagaacaa gaatgtggtg gtggctgact tcgggctggc gcgtctcatg     1620

gtggacgaga agactcagcc tgagggcctg cggagcctca agaagccaga ccgcaagaag     1680

cgctacaccg tggtgggcaa cccctactgg atggcacctg agatgatcaa cggccgcagc     1740

tatgatgaga aggtggatgt gttctccttt gggatcgtcc tgtgcgagat catcgggcgg     1800

gtgaacgcag accctgacta cctgccccgc accatggact ttggcctcaa cgtgcgagga     1860

ttcctggacc gctactgccc cccaaactgc cccccgagct tcttccccat caccgtgcgc     1920

tgttgcgatc tggaccccga gaagaggcca tcctttgtga agctggaaca ctggctggag     1980

accctccgca tgcacctggc cggccacctg ccactgggcc cacagctgga gcagctggac     2040

agaggtttct gggagaccta ccggcgcggc gagagcggac tgcctgccca ccctgaggtc     2100

cccgactgag ccagggccac tcagctgccc ctgtccccac ctctggagaa tccaccccca     2160

ccagattcct ccgcgggagg tggccctcag ctgggacagt ggggacccag gcttctcctc     2220

agagccaggc cctgacttgc cttctcccac cccgtggacc gcttcccctg ccttctctct     2280

gccgtggccc agagccggcc cagctgcaca cacacaccat gctctcgccc tgctgtaacc     2340

tctgtcttgg cagggctgtc ccctcttgct tctccttgca tgagctggag ggcctgtgtg     2400

agttacgccc ctttccacac gccgctgccc cagcaaccct gttcacgctc cacctgtctg     2460

gtccatagct ccctggaggc tgggccagga ggcagcctcc gaaccatgcc ccatataacg     2520

cttgggtgcg tgggagggcg cacatcaggg cagaggccaa gttccaggtg tctgtgttcc     2580

caggaaccaa atggggagtc tggggcccgt tttcccccca gggggtgtct aggtagcaac     2640

aggtatcgag gactctccaa acccccaaag cagagagagg gctgatccca tggggcggag     2700

gtccccagtg gctgagcaaa cagccccttc tctcgctttg ggtctttttt ttgtttcttt     2760

cttaaagcca ctttagtgag aagcaggtac caagcctcag ggtgaagggg gtcccttgag     2820

ggagcgtgga gctgcggtgc cctggccggc gatggggagg agccggctcc ggcagtgaga     2880

ggataggcac agtggaccgg gcaggtgtcc accagcagct cagcccctgc agtcatctca     2940

gagccccttc ccgggcctct cccccaaggc tccctgcccc tcctcatgcc cctctgtcct     3000

ctgcgttttt tctgtgtaat ctatttttta agaagagttt gtattatttt ttcatacggc     3060

tgcagcagca gctgccaggg gcttgggatt ttatttttgt ggcgggcggg ggtgggaggg     3120

ccattttgtc actttgcctc agttgagcat ctaggaagta ttaaaactgt gaagctttct     3180

cagtgcactt tgaacctgga aaacaatccc aacaggcccg tgggaccatg acttagggag     3240

gtgggaccca cccaccccca tccaggaacc gtgacgtcca aggaaccaaa cccagacgca     3300

gaacaataaa ataaattccg tactccccac cc                                   3332


<210>  25
<211>  5217
<212>  DNA
<213>  Homo sapiens

<400>  25
atcgaggtcc gcgggaggct cggagcgcgc caggcggaca ctcctctcgg ctcctccccg       60

gcagcggcgg cggctcggag cgggctccgg ggctcgggtg cagcggccag cgggcgcctg      120

gcggcgagga ttacccgggg aagtggttgt ctcctggctg gagccgcgag acgggcgctc      180

agggcgcggg gccggcggcg gcgaacgaga ggacggactc tggcggccgg gtcgttggcc      240

gcggggagcg cgggcaccgg gcgagcaggc cgcgtcgcgc tcaccatggt cagctactgg      300

gacaccgggg tcctgctgtg cgcgctgctc agctgtctgc ttctcacagg atctagttca      360

ggttcaaaat taaaagatcc tgaactgagt ttaaaaggca cccagcacat catgcaagca      420

ggccagacac tgcatctcca atgcaggggg gaagcagccc ataaatggtc tttgcctgaa      480

atggtgagta aggaaagcga aaggctgagc ataactaaat ctgcctgtgg aagaaatggc      540

aaacaattct gcagtacttt aaccttgaac acagctcaag caaaccacac tggcttctac      600

agctgcaaat atctagctgt acctacttca aagaagaagg aaacagaatc tgcaatctat      660

atatttatta gtgatacagg tagacctttc gtagagatgt acagtgaaat ccccgaaatt      720

atacacatga ctgaaggaag ggagctcgtc attccctgcc gggttacgtc acctaacatc      780

actgttactt taaaaaagtt tccacttgac actttgatcc ctgatggaaa acgcataatc      840

tgggacagta gaaagggctt catcatatca aatgcaacgt acaaagaaat agggcttctg      900

acctgtgaag caacagtcaa tgggcatttg tataagacaa actatctcac acatcgacaa      960

accaatacaa tcatagatgt ccaaataagc acaccacgcc cagtcaaatt acttagaggc     1020

catactcttg tcctcaattg tactgctacc actcccttga acacgagagt tcaaatgacc     1080

tggagttacc ctgatgaaaa aaataagaga gcttccgtaa ggcgacgaat tgaccaaagc     1140

aattcccatg ccaacatatt ctacagtgtt cttactattg acaaaatgca gaacaaagac     1200

aaaggacttt atacttgtcg tgtaaggagt ggaccatcat tcaaatctgt taacacctca     1260

gtgcatatat atgataaagc attcatcact gtgaaacatc gaaaacagca ggtgcttgaa     1320

accgtagctg gcaagcggtc ttaccggctc tctatgaaag tgaaggcatt tccctcgccg     1380

gaagttgtat ggttaaaaga tgggttacct gcgactgaga aatctgctcg ctatttgact     1440

cgtggctact cgttaattat caaggacgta actgaagagg atgcagggaa ttatacaatc     1500

ttgctgagca taaaacagtc aaatgtgttt aaaaacctca ctgccactct aattgtcaat     1560

gtgaaacccc agatttacga aaaggccgtg tcatcgtttc cagacccggc tctctaccca     1620

ctgggcagca gacaaatcct gacttgtacc gcatatggta tccctcaacc tacaatcaag     1680

tggttctggc acccctgtaa ccataatcat tccgaagcaa ggtgtgactt ttgttccaat     1740

aatgaagagt cctttatcct ggatgctgac agcaacatgg gaaacagaat tgagagcatc     1800

actcagcgca tggcaataat agaaggaaag aataagatgg ctagcacctt ggttgtggct     1860

gactctagaa tttctggaat ctacatttgc atagcttcca ataaagttgg gactgtggga     1920

agaaacataa gcttttatat cacagatgtg ccaaatgggt ttcatgttaa cttggaaaaa     1980

atgccgacgg aaggagagga cctgaaactg tcttgcacag ttaacaagtt cttatacaga     2040

gacgttactt ggattttact gcggacagtt aataacagaa caatgcacta cagtattagc     2100

aagcaaaaaa tggccatcac taaggagcac tccatcactc ttaatcttac catcatgaat     2160

gtttccctgc aagattcagg cacctatgcc tgcagagcca ggaatgtata cacaggggaa     2220

gaaatcctcc agaagaaaga aattacaatc agagatcagg aagcaccata cctcctgcga     2280

aacctcagtg atcacacagt ggccatcagc agttccacca ctttagactg tcatgctaat     2340

ggtgtccccg agcctcagat cacttggttt aaaaacaacc acaaaataca acaagagcct     2400

ggaattattt taggaccagg aagcagcacg ctgtttattg aaagagtcac agaagaggat     2460

gaaggtgtct atcactgcaa agccaccaac cagaagggct ctgtggaaag ttcagcatac     2520

ctcactgttc aaggaacctc ggacaagtct aatctggagc tgatcactct aacatgcacc     2580

tgtgtggctg cgactctctt ctggctccta ttaaccctct ttatccgaaa aatgaaaagg     2640

tcttcttctg aaataaagac tgactaccta tcaattataa tggacccaga tgaagttcct     2700

ttggatgagc agtgtgagcg gctcccttat gatgccagca agtgggagtt tgcccgggag     2760

agacttaaac tgggcaaatc acttggaaga ggggcttttg gaaaagtggt tcaagcatca     2820

gcatttggca ttaagaaatc acctacgtgc cggactgtgg ctgtgaaaat gctgaaagag     2880

ggggccacgg ccagcgagta caaagctctg atgactgagc taaaaatctt gacccacatt     2940

ggccaccatc tgaacgtggt taacctgctg ggagcctgca ccaagcaagg agggcctctg     3000

atggtgattg ttgaatactg caaatatgga aatctctcca actacctcaa gagcaaacgt     3060

gacttatttt ttctcaacaa ggatgcagca ctacacatgg agcctaagaa agaaaaaatg     3120

gagccaggcc tggaacaagg caagaaacca agactagata gcgtcaccag cagcgaaagc     3180

tttgcgagct ccggctttca ggaagataaa agtctgagtg atgttgagga agaggaggat     3240

tctgacggtt tctacaagga gcccatcact atggaagatc tgatttctta cagttttcaa     3300

gtggccagag gcatggagtt cctgtcttcc agaaagtgca ttcatcggga cctggcagcg     3360

agaaacattc ttttatctga gaacaacgtg gtgaagattt gtgattttgg ccttgcccgg     3420

gatatttata agaaccccga ttatgtgaga aaaggagata ctcgacttcc tctgaaatgg     3480

atggctcctg aatctatctt tgacaaaatc tacagcacca agagcgacgt gtggtcttac     3540

ggagtattgc tgtgggaaat cttctcctta ggtgggtctc catacccagg agtacaaatg     3600

gatgaggact tttgcagtcg cctgagggaa ggcatgagga tgagagctcc tgagtactct     3660

actcctgaaa tctatcagat catgctggac tgctggcaca gagacccaaa agaaaggcca     3720

agatttgcag aacttgtgga aaaactaggt gatttgcttc aagcaaatgt acaacaggat     3780

ggtaaagact acatcccaat caatgccata ctgacaggaa atagtgggtt tacatactca     3840

actcctgcct tctctgagga cttcttcaag gaaagtattt cagctccgaa gtttaattca     3900

ggaagctctg atgatgtcag atacgtaaat gctttcaagt tcatgagcct ggaaagaatc     3960

aaaacctttg aagaactttt accgaatgcc acctccatgt ttgatgacta ccagggcgac     4020

agcagcactc tgttggcctc tcccatgctg aagcgcttca cctggactga cagcaaaccc     4080

aaggcctcgc tcaagattga cttgagagta accagtaaaa gtaaggagtc ggggctgtct     4140

gatgtcagca ggcccagttt ctgccattcc agctgtgggc acgtcagcga aggcaagcgc     4200

aggttcacct acgaccacgc tgagctggaa aggaaaatcg cgtgctgctc cccgccccca     4260

gactacaact cggtggtcct gtactccacc ccacccatct agagtttgac acgaagcctt     4320

atttctagaa gcacatgtgt atttataccc ccaggaaact agcttttgcc agtattatgc     4380

atatataagt ttacaccttt atctttccat gggagccagc tgctttttgt gattttttta     4440

atagtgcttt tttttttttg actaacaaga atgtaactcc agatagagaa atagtgacaa     4500

gtgaagaaca ctactgctaa atcctcatgt tactcagtgt tagagaaatc cttcctaaac     4560

ccaatgactt ccctgctcca acccccgcca cctcagggca cgcaggacca gtttgattga     4620

ggagctgcac tgatcaccca atgcatcacg taccccactg ggccagccct gcagcccaaa     4680

acccagggca acaagcccgt tagccccagg gatcactggc tggcctgagc aacatctcgg     4740

gagtcctcta gcaggcctaa gacatgtgag gaggaaaagg aaaaaaagca aaaagcaagg     4800

gagaaaagag aaaccgggag aaggcatgag aaagaatttg agacgcacca tgtgggcacg     4860

gagggggacg gggctcagca atgccatttc agtggcttcc cagctctgac ccttctacat     4920

ttgagggccc agccaggagc agatggacag cgatgagggg acattttctg gattctggga     4980

ggcaagaaaa ggacaaatat cttttttgga actaaagcaa attttagaac tttacctatg     5040

gaagtggttc tatgtccatt ctcattcgtg gcatgttttg atttgtagca ctgagggtgg     5100

cactcaactc tgagcccata cttttggctc ctctagtaag atgcactgaa aacttagcca     5160

gagttaggtt gtctccaggc catgatggcc ttacactgaa aatgtcacat tctattt        5217


<210>  26
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe 
        35                  40                  45              


Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn 
    50                  55                  60                  


Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser 
65                  70                  75                  80  


Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp 
                85                  90                  95      


Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala 
            100                 105                 110         


Tyr Gly Ser Val Asn Lys Met Val His Lys Pro Ser Gly Gln Ile Met 
        115                 120                 125             


Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
    130                 135                 140                 


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
145                 150                 155                 160 


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
                165                 170                 175     


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
            180                 185                 190         


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
        195                 200                 205             


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
    210                 215                 220                 


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
                245                 250                 255     


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
            260                 265                 270         


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
        275                 280                 285             


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
    290                 295                 300                 


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
305                 310                 315                 320 


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
                325                 330                 335     


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
            340                 345                 350         


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
        355                 360                 365             


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
    370                 375                 380                 


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
385                 390                 395                 


<210>  27
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Leu Ser Lys Phe Gly Ser Leu Ala His Leu Cys Gly Pro Gly 
1               5                   10                  15      


Gly Val Asp His Leu Pro Val Lys Ile Leu Gln Pro Ala Lys Ala Asp 
            20                  25                  30          


Lys Glu Ser Phe Glu Lys Ala Tyr Gln Val Gly Ala Val Leu Gly Ser 
        35                  40                  45              


Gly Gly Phe Gly Thr Val Tyr Ala Gly Ser Arg Ile Ala Asp Gly Leu 
    50                  55                  60                  


Pro Val Ala Val Lys His Val Val Lys Glu Arg Val Thr Glu Trp Gly 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Thr Val Pro Leu Glu Val Val Leu Leu Arg Lys 
                85                  90                  95      


Val Gly Ala Ala Gly Gly Ala Arg Gly Val Ile Arg Leu Leu Asp Trp 
            100                 105                 110         


Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu Arg Pro Glu Pro 
        115                 120                 125             


Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Asp Glu 
    130                 135                 140                 


Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala Ala Val Arg His 
145                 150                 155                 160 


Cys His Ser Cys Gly Val Val His Arg Asp Ile Lys Asp Glu Asn Leu 
                165                 170                 175     


Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser 
            180                 185                 190         


Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg 
        195                 200                 205             


Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg 
    210                 215                 220                 


Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr Asp Met Val Cys 
225                 230                 235                 240 


Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu Arg Gly Arg Leu 
                245                 250                 255     


Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln Leu Ile Arg Trp 
            260                 265                 270         


Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu Asp Gln Ile Ala 
        275                 280                 285             


Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly Ala Pro Glu Ser Cys 
    290                 295                 300                 


Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp Val Ala Ser Thr Thr 
305                 310                 315                 320 


Ser Ser Ser Glu Ser Leu 
                325     


<210>  28
<211>  1253
<212>  DNA
<213>  Homo sapiens

<400>  28
gggcggccgg gagagtagca gtgccttgga ccccagctct cctccccctt tctctctaag       60

gatggcccag aaggagaact cctacccctg gccctacggc cgacagacgg ctccatctgg      120

cctgagcacc ctgccccagc gagtcctccg gaaagagcct gtcaccccat ctgcacttgt      180

cctcatgagc cgctccaatg tccagcccac agctgcccct ggccagaagg tgatggagaa      240

tagcagtggg acacccgaca tcttaacgcg gcacttcaca attgatgact ttgagattgg      300

gcgtcctctg ggcaaaggca agtttggaaa cgtgtacttg gctcgggaga agaaaagcca      360

tttcatcgtg gcgctcaagg tcctcttcaa gtcccagata gagaaggagg gcgtggagca      420

tcagctgcgc agagagatcg aaatccaggc ccacctgcac catcccaaca tcctgcgtct      480

ctacaactat ttttatgacc ggaggaggat ctacttgatt ctagagtatg ccccccgcgg      540

ggagctctac aaggagctgc agaagagctg cacatttgac gagcagcgaa cagccacgat      600

catggaggag ttggcagatg ctctaatgta ctgccatggg aagaaggtga ttcacagaga      660

cataaagcca gaaaatctgc tcttagggct caagggagag ctgaagattg ctgacttcgg      720

ctggtctgtg catgcgccct ccctgaggag gaagacaatg tgtggcaccc tggactacct      780

gcccccagag atgattgagg ggcgcatgca caatgagaag gtggatctgt ggtgcattgg      840

agtgctttgc tatgagctgc tggtggggaa cccacccttt gagagtgcat cacacaacga      900

gacctatcgc cgcatcgtca aggtggacct aaagttcccc gcttccgtgc ccatgggagc      960

ccaggacctc atctccaaac tgctcaggca taacccctcg gaacggctgc ccctggccca     1020

ggtctcagcc cacccttggg tccgggccaa ctctcggagg gtgctgcctc cctctgccct     1080

tcaatctgtc gcctgatggt ccctgtcatt cactcgggtg cgtgtgtttg tatgtctgtg     1140

tatgtatagg ggaaagaagg gatccctaac tgttccctta tctgttttct acctcctcct     1200

ttgtttaata aaggctgaag ctttttgtac tcatgaaaaa aaaaaaaaaa aaa            1253


<210>  29
<211>  1499
<212>  DNA
<213>  Homo sapiens

<400>  29
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg       60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt      120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga      180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac      240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac      300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc      360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag      420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat      480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat      540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac      600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc      660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc      720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac      780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg      840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa      900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt      960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct     1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca     1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag     1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt     1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag     1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct     1320

taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt     1380

ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct     1440

tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaa      1499


<210>  30
<211>  2423
<212>  DNA
<213>  Homo sapiens

<400>  30
ggtttgtggt tggctgaggt ggaggaataa aatggcggcg ccggcggcgt gaccgggccc       60

tctggcccac agccattggt agcggtggca gcagtactgc tgccccaact cgctgtgccc      120

cctttctcag cccacgacat cgccacgaca gcgaggcagc gaccgccacc gagaaagagg      180

tggtggccca gcctggaacc ttgagaaacc ctcgcaaact gtggcctggc ggaaatcctg      240

gtgtgctgca gggatcaggc tgactccagg ccctgtaaca ccgggaaacg cctcggtggc      300

catttccagc agccctcatc ctcagccttg cgggccggtg ggccccggag gcctccatcc      360

tcccctagag gggtcagggc tgagcccagc ctccatcttt gcctctcagg atgacaaaca      420

acagcggctc caaagccgaa ctcgttgtgg gagggaaata caaactggtg cggaagatcg      480

ggtctggctc ctttggagac gtttatctgg gcatcaccac caccaacggc gaggaagtag      540

cagtgaagct ggaatctcag aaggtcaagc acccccagtt gctgtatgag agcaaactct      600

acacgattct tcaaggtggg gttggcatcc cccacatgca ctggtatggt caggaaaaag      660

acaacaatgt gctagtcatg gaccttctgg gacccagcct cgaagacctc tttaatttct      720

gttcaagaag gttcaccatg aaaactgtac ttatgttagc cgaccagatg atcagcagaa      780

ttgaatacgt gcatacaaag aattttctac accgagacat taaaccagat aacttcctga      840

tgggtactgg gcgtcactgt aataagttgt tccttattga ttttggtttg gccaaaaagt      900

acagagacaa caggaccagg caacacatac cgtacagaga agataaacac ctcattggca      960

ctgtccgata tgccagcatc aatgcacatc ttggtattga gcagagccgc cgagatgaca     1020

tggaatcctt aggctacgtt ttcatgtatt ttaatagaac cagcctgccg tggcaaggac     1080

taaaggctat gacaaaaaaa caaaaatatg aaaagattag tgagaagaag atgtccaccc     1140

ctgttgaagt tttatgtaag gggtttcctg cagaattcgc catgtacttg aactactgtc     1200

gtgggctgcg ctttgaggaa gtcccagatt acatgtatct gaggcagcta ttccgcattc     1260

ttttcaggac cctgaaccac caatatgact acacatttga ttggacgatg ttaaagcaga     1320

aagcagcaca gcaggcagcc tcttccagtg ggcagggtca gcaggcccaa acccagacag     1380

gcaagcaaac tgaaaaaaac aagaataatg tgaaagataa ctaagcgtga atgaggaaca     1440

gaagaagcag agcagatgat tcgagcagca tttgtttctc cccacatcta gaaattgtag     1500

ttcatatgta caccagctag tggctgtgaa caaccattta gttggtgtaa aaaactttat     1560

ttcaatataa actgactctg gggagcgttg gtgatgctgt atcccaaagt gtagcctctg     1620

taattgtgaa tattaactga ggtagtgaaa cgtgatgtct ggttttctat tgcatttatt     1680

caagtagaaa agttaactaa atggttgaca cacacgaatt ggtggagaca ttgtccatat     1740

gccaattttt tgttaaaacc ttttattttg aactagactg ctttgagata tcatttcaga     1800

aggacagtct tcagccacag ctgcaaaggt tgtaaatgct tatgattgag catttttagg     1860

gtttctccat ccctggggtt tgcaaattgt tcacataaag agcattctta aaatggttgg     1920

cttcttgtct gtaagccagc tgatctagta gtaaccaaaa attccagttt tgagaatagg     1980

aaagattccg cctgcttacc tgtgaagaca taagaaaatc ttagtaacta ccagattatc     2040

tttagaattc cacattaact atatcatgtt ctcggtattt taaaaacaac aacaaccata     2100

tttgtcacag aaatttagtt aacatcttac aactgaacat gtatgtacat ggcttagata     2160

aatgtaatca ccgtaaacac ctatatgatc tgggattttg ttcatatttt gaaatgggag     2220

cttttatgtt ttacaagttc actaaaatct gaaaactgtt tctataagga aataatactt     2280

ttttaaacaa caaccaaaaa atgccttgct gattcactag gaaataaaaa tctccccaat     2340

tttttgatag tcaacttcga gccatttgtt acatgatatt cccttgcaag taaattttat     2400

ttcattacaa aaaaaaaaaa aaa                                             2423


<210>  31
<211>  2105
<212>  DNA
<213>  Homo sapiens

<400>  31
gttgccatta ggggactcct gaggtcctat ctccaggctg cggtgactgc actttccctg       60

gagtggaagc tgctggaagg cggaccggcc gccatgtcca cgttcaggca ggaggacgtg      120

gaggaccatt atgagatggg ggaggagctg ggcagcggcc agtttgcgat cgtgcggaag      180

tgccggcaga agggcacggg caaggagtac gcagccaagt tcatcaagaa gcgccgcctg      240

tcatccagcc ggcgtggggt gagccgggag gagatcgagc gggaggtgaa catcctgcgg      300

gagatccggc accccaacat catcaccctg cacgacatct tcgagaacaa gacggacgtg      360

gtcctcatcc tggagctggt ctctggcggg gagctctttg acttcctggc ggagaaagag      420

tcgctgacgg aggacgaggc cacccagttc ctcaagcaga tcctggacgg cgttcactac      480

ctgcactcta agcgcatcgc acactttgac ctgaagccgg aaaacatcat gctgctggac      540

aagaacgtgc ccaacccacg aatcaagctc atcgacttcg gcatcgcgca caagatcgag      600

gcggggaacg agttcaagaa catcttcggc accccggagt ttgtggcccc agagattgtg      660

aactatgagc cgctgggcct ggaggcggac atgtggagca tcggtgtcat cacctatatc      720

ctcctgagcg gtgcatcccc gttcctgggc gagaccaagc aggagacgct caccaacatc      780

tcagccgtga actacgactt cgacgaggag tacttcagca acaccagcga gctggccaag      840

gacttcattc gccggctgct cgtcaaagat cccaagcgga gaatgaccat tgcccagagc      900

ctggaacatt cctggattaa ggcgatccgg cggcggaacg tgcgtggtga ggacagcggc      960

cgcaagcccg agcggcggcg cctgaagacc acgcgtctga aggagtacac catcaagtcg     1020

cactccagct tgccgcccaa caacagctac gccgacttcg agcgcttctc caaggtgctg     1080

gaggaggcgg cggccgccga ggagggcctg cgcgagctgc agcgcagccg gcggctctgc     1140

cacgaggacg tggaggcgct ggccgccatc tacgaggaga aggaggcctg gtaccgcgag     1200

gagagcgaca gcctgggcca ggacctgcgg aggctacggc aggagctgct caagaccgag     1260

gcgctcaagc ggcaggcgca ggaggaggcc aagggcgcgc tgctggggac cagcggcctc     1320

aagcgccgct tcagccgcct ggagaaccgc tacgaggcgc tggccaagca agtagcctcc     1380

gagatgcgct tcgtgcagga cctcgtgcgc gccctggagc aggagaagct gcagggcgtg     1440

gagtgcgggc tgcgctaggc gcagtggggt gggccaggcc ccaggacagc cggagctcgg     1500

cctgcggtgg gggcgcttcc tgtggacgct gcgcctccca tcgcccgggt gcctgtcctt     1560

gcccagcgcc accaggctgg aggcggagtg ggaggagctg gagccaggcc cgtaagttcg     1620

caggcagggg tgggtgtggg acggggctgc ttctctacac agcctctacg ctggccttca     1680

ccttcacccc tgcatcgtcg gtgaccctgg gaccctccag gcagcgtggc ctgtggcacc     1740

gtgagggttg ggacccaccg aggcgcagag gcggcccgaa tgcagccctg gttcaggccc     1800

ggaggagggt ttgcgggtag ttgcacggac aattcggcgg ggtgctgcct gttgctgcca     1860

ttagcccagg aggaggtcgt gggacgggga gggtgggatg gacggcggac aggcagtccc     1920

cacgctgctg ggtggcgccg ggcttggtgg ggtcttccac tgtgtgccct tctcgccgag     1980

gccggtcccc cgggtgtggg gtgccctgct gcggactcct ccgcgagccc catcgtcgcg     2040

cctgtggacg cctaggcaag agcggccctc tgcagccaag agaaataaaa tactggcttc     2100

cagat                                                                 2105


<210>  32
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Gly Thr Ser Lys Glu Ser Leu Gly His Gly Gly Leu Pro Gly 
1               5                   10                  15      


Leu Gly Lys Thr Cys Leu Thr Thr Met Asp Thr Lys Leu Asn Met Leu 
            20                  25                  30          


Asn Glu Lys Val Asp Gln Leu Leu His Phe Gln Glu Asp Val Thr Glu 
        35                  40                  45              


Lys Leu Gln Ser Met Cys Arg Asp Met Gly His Leu Glu Arg Gly Leu 
    50                  55                  60                  


His Arg Leu Glu Ala Ser Arg Ala Pro Gly Pro Gly Gly Ala Asp Gly 
65                  70                  75                  80  


Val Pro His Ile Asp Thr Gln Ala Gly Trp Pro Glu Val Leu Glu Leu 
                85                  90                  95      


Val Arg Ala Met Gln Gln Asp Ala Ala Gln His Gly Ala Arg Leu Glu 
            100                 105                 110         


Ala Leu Phe Arg Met Val Ala Ala Val Asp Arg Ala Ile Ala Leu Val 
        115                 120                 125             


Gly Ala Thr Phe Gln Lys Ser Lys Val Ala Asp Phe Leu Met Gln Gly 
    130                 135                 140                 


Arg Val Pro Trp Arg Arg Gly Ser Pro Gly Asp Ser Pro Glu Glu Asn 
145                 150                 155                 160 


Lys Glu Arg Val Glu Glu Glu Gly Gly Lys Pro Lys His Val Leu Ser 
                165                 170                 175     


Thr Ser Gly Val Gln Ser Asp Ala Arg Glu Pro Gly Glu Glu Ser Gln 
            180                 185                 190         


Lys Ala Asp Val Leu Glu Gly Thr Ala Glu Arg Leu Pro Pro Ile Arg 
        195                 200                 205             


Ala Ser Gly Leu Gly Ala Asp Pro Ala Gln Ala Val Val Ser Pro Gly 
    210                 215                 220                 


Gln Gly Asp Gly Val Pro Gly Pro Ala Gln Ala Phe Pro Gly His Leu 
225                 230                 235                 240 


Pro Leu Pro Thr Lys Val Glu Ala Lys Ala Pro Glu Thr Pro Ser Glu 
                245                 250                 255     


Asn Leu Arg Thr Gly Leu Glu Leu Ala Pro Ala Pro Gly Arg Val Asn 
            260                 265                 270         


Val Val Ser Pro Ser Leu Glu Val Ala Pro Gly Ala Gly Gln Gly Ala 
        275                 280                 285             


Ser Ser Ser Arg Pro Asp Pro Glu Pro Leu Glu Glu Gly Thr Arg Leu 
    290                 295                 300                 


Thr Pro Gly Pro Gly Pro Gln Cys Pro Gly Pro Pro Gly Leu Pro Ala 
305                 310                 315                 320 


Gln Ala Arg Ala Thr His Ser Gly Gly Glu Thr Pro Pro Arg Ile Ser 
                325                 330                 335     


Ile His Ile Gln Glu Met Asp Thr Pro Gly Glu Met Leu Met Thr Gly 
            340                 345                 350         


Arg Gly Ser Leu Gly Pro Thr Leu Thr Thr Glu Ala Pro Ala Ala Ala 
        355                 360                 365             


Gln Pro Gly Lys Gln Gly Pro Pro Gly Thr Gly Arg Cys Leu Gln Ala 
    370                 375                 380                 


Pro Gly Thr Glu Pro Gly Glu Gln Thr Pro Glu Gly Ala Arg Glu Leu 
385                 390                 395                 400 


Ser Pro Leu Gln Glu Ser Ser Ser Pro Gly Gly Val Lys Ala Glu Glu 
                405                 410                 415     


Glu Gln Arg Ala Gly Ala Glu Pro Gly Thr Arg Pro Ser Leu Ala Arg 
            420                 425                 430         


Ser Asp Asp Asn Asp His Glu Val Gly Ala Leu Gly Leu Gln Gln Gly 
        435                 440                 445             


Lys Ser Pro Gly Ala Gly Asn Pro Glu Pro Glu Gln Asp Cys Ala Ala 
    450                 455                 460                 


Arg Ala Pro Val Arg Ala Glu Ala Val Arg Arg Met Pro Pro Gly Ala 
465                 470                 475                 480 


Glu Ala Gly Ser Val Val Leu Asp Asp Ser Pro Ala Pro Pro Ala Pro 
                485                 490                 495     


Phe Glu His Arg Val Val Ser Val Lys Glu Thr Ser Ile Ser Ala Gly 
            500                 505                 510         


Tyr Glu Val Cys Gln His Glu Val Leu Gly Gly Gly Arg Phe Gly Gln 
        515                 520                 525             


Val His Arg Cys Thr Glu Lys Ser Thr Gly Leu Pro Leu Ala Ala Lys 
    530                 535                 540                 


Ile Ile Lys Val Lys Ser Ala Lys Asp Arg Glu Asp Val Lys Asn Glu 
545                 550                 555                 560 


Ile Asn Ile Met Asn Gln Leu Ser His Val Asn Leu Ile Gln Leu Tyr 
                565                 570                 575     


Asp Ala Phe Glu Ser Lys His Ser Cys Thr Leu Val Met Glu Tyr Val 
            580                 585                 590         


Asp Gly Gly Glu Leu Phe Asp Arg Ile Thr Asp Glu Lys Tyr His Leu 
        595                 600                 605             


Thr Glu Leu Asp Val Val Leu Phe Thr Arg Gln Ile Cys Glu Gly Val 
    610                 615                 620                 


His Tyr Leu His Gln His Tyr Ile Leu His Leu Asp Leu Lys Pro Glu 
625                 630                 635                 640 


Asn Ile Leu Cys Val Asn Gln Thr Gly His Gln Ile Lys Ile Ile Asp 
                645                 650                 655     


Phe Gly Leu Ala Arg Arg Tyr Lys Pro Arg Glu Lys Leu Lys Val Asn 
            660                 665                 670         


Phe Gly Thr Pro Glu Phe Leu Ala Pro Glu Val Val Asn Tyr Glu Phe 
        675                 680                 685             


Val Ser Phe Pro Thr Asp Met Trp Ser Val Gly Val Ile Thr Tyr Met 
    690                 695                 700                 


Leu Leu Ser Gly Leu Ser Pro Phe Leu Gly Glu Thr Asp Ala Glu Thr 
705                 710                 715                 720 


Met Asn Phe Ile Val Asn Cys Ser Trp Asp Phe Asp Ala Asp Thr Phe 
                725                 730                 735     


Glu Gly Leu Ser Glu Glu Ala Lys Asp Phe Val Ser Arg Leu Leu Val 
            740                 745                 750         


Lys Glu Lys Ser Cys Arg Met Ser Ala Thr Gln Cys Leu Lys His Glu 
        755                 760                 765             


Trp Leu Asn Asn Leu Pro Ala Lys Ala Ser Arg Ser Lys Thr Arg Leu 
    770                 775                 780                 


Lys Ser Gln Leu Leu Leu Gln Lys Tyr Ile Ala Gln Arg Lys Trp Lys 
785                 790                 795                 800 


Lys His Phe Tyr Val Val Thr Ala Ala Asn Arg Leu Arg Lys Phe Pro 
                805                 810                 815     


Thr Ser Pro 
            


<210>  33
<211>  1762
<212>  DNA
<213>  Homo sapiens

<400>  33
ggggcactgg tacctccagg acctggagtg tactggaaga aatggtgcag tccagatgca       60

tcactgtaag cgataccgct cccctgaacc agacccgtac ctgagctacc gatggaagag      120

gaggaggtcc tacagtcggg aacatgaagg gagactgcga tacccgtccc gaagggagcc      180

tcccccacga agatctcggt ccagaagcca tgaccgcctg ccctaccaga ggaggtaccg      240

ggagcgccgt gacagcgata cataccggtg tgaagagcgg agcccatcct ttggagagga      300

ctactatgga ccttcacgtt ctcgtcatcg tcggcgatcg cgggagaggg ggccataccg      360

gacccgcaag catgcccacc actgccacaa acgccgcacc aggtcttgta gcagcgcctc      420

ctcgagaagc caacagagca gtaagcgcag cagccggagt gtggaagatg acaaggaggg      480

tcacctggtg tgccggatcg gcgattggct ccaagagcga tatgagattg tggggaacct      540

gggtgaaggc acctttggca aggtggtgga gtgcttggac catgccagag ggaagtctca      600

ggttgccctg aagatcatcc gcaacgtggg caagtaccgg gaggctgccc ggctagaaat      660

caacgtgctc aaaaaaatca aggagaagga caaagaaaac aagttcctgt gtgtcttgat      720

gtctgactgg ttcaacttcc acggtcacat gtgcatcgcc tttgagctcc tgggcaagaa      780

cacctttgag ttcctgaagg agaataactt ccagccttac cccctaccac atgtccggca      840

catggcctac cagctctgcc acgcccttag atttctgcat gagaatcagc tgacccatac      900

agacttgaaa ccagagaaca tcctgtttgt gaattctgag tttgaaaccc tctacaatga      960

gcacaagagc tgtgaggaga agtcagtgaa gaacaccagc atccgagtgg ctgactttgg     1020

cagtgccaca tttgaccatg agcaccacac caccattgtg gccacccgtc actatcgccc     1080

gcctgaggtg atccttgagc tgggctgggc acagccctgt gacgtctgga gcattggctg     1140

cattctcttt gagtactacc ggggcttcac actcttccag acccacgaaa accgagagca     1200

cctggtgatg atggagaaga tcctagggcc catcccatca cacatgatcc accgtaccag     1260

gaagcagaaa tatttctaca aagggggcct agtttgggat gagaacagct ctgacggccg     1320

gtatgtgaag gagaactgca aacctctgaa gagttacatg ctccaagact ccctggagca     1380

cgtgcagctg tttgacctga tgaggaggat gttagaattt gaccctgccc agcgcatcac     1440

actggccgag gccctgctgc accccttctt tgctggcctg acccctgagg agcggtcctt     1500

ccacaccagc cgcaacccaa gcagatgaca ggcacaggcc accgcatgag gagatggagg     1560

gcgggactgg gccgcccagc cccttgactc cagcctcgac cgccaggccc caggccagag     1620

ccacccaatg aacagtgcaa tgtgaaggaa ggcaggagcc tgcaggggag cagacttggt     1680

gcccagctgc cagaaagcac agatttgacc caagctattt atatgttata aagttataat     1740

aaagtgtttc ttactgtttg ta                                              1762


<210>  34
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  34

Met His Gly Tyr Phe Gly Cys Asn Ala Ala Ala Glu Pro Gly Tyr Ser 
1               5                   10                  15      


Ala Phe Val Gly Thr Pro Gln Ile Cys Val Thr Lys Met Ser Thr Arg 
            20                  25                  30          


Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu Asp Thr Ile Pro 
        35                  40                  45              


Glu Asp Lys Lys Val Arg Val Gln Arg Thr Gln Ser Thr Phe Asp Pro 
    50                  55                  60                  


Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His Ser Glu Asn Asn 
65                  70                  75                  80  


Ala Cys Ile Asn Phe Lys Thr Ser Ser Thr Gly Lys Glu Ser Pro Lys 
                85                  90                  95      


Val Arg Arg His Ser Ser Pro Ser Ser Pro Thr Ser Pro Lys Phe Gly 
            100                 105                 110         


Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly Ser Tyr 
        115                 120                 125             


Ala Thr Val Tyr Lys Gly Lys Ser Lys Val Asn Gly Lys Leu Val Ala 
    130                 135                 140                 


Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Thr Pro Phe Thr Ala 
145                 150                 155                 160 


Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile Val 
                165                 170                 175     


Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Leu Val Phe 
            180                 185                 190         


Glu Tyr Val His Thr Asp Leu Cys Gln Tyr Met Asp Lys His Pro Gly 
        195                 200                 205             


Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg 
    210                 215                 220                 


Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp Leu Lys 
225                 230                 235                 240 


Pro Gln Asn Leu Leu Ile Ser Asp Thr Gly Glu Leu Lys Leu Ala Asp 
                245                 250                 255     


Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Thr Tyr Ser Asn 
            260                 265                 270         


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser 
        275                 280                 285             


Thr Glu Tyr Ser Thr Cys Leu Asp Met Trp Gly Val Gly Cys Ile Phe 
    290                 295                 300                 


Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys Asp Ile 
305                 310                 315                 320 


Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Thr Pro Asn Glu 
                325                 330                 335     


Asp Thr Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro Glu Arg 
            340                 345                 350         


Phe Thr Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn Lys Leu 
        355                 360                 365             


Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu Gln Cys 
    370                 375                 380                 


Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His Glu Tyr 
385                 390                 395                 400 


Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Thr Asp Met Ser Ser 
                405                 410                 415     


Ile Phe Thr Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly Glu Ser 
            420                 425                 430         


Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu Ser Asn 
        435                 440                 445             


Ser Lys His 
    450     


<210>  35
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Leu Pro 
1               5                   10                  15      


Thr Ala Ile Pro Ala Val Leu Pro Ala Ala Ser Pro Cys Ser Ser Pro 
            20                  25                  30          


Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro 
        35                  40                  45              


Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu 
    50                  55                  60                  


Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu 
65                  70                  75                  80  


Ser Leu Ser Ala Val Lys Asp Leu Val Cys Ser Ile Val Tyr Gln Lys 
                85                  90                  95      


Phe Pro Glu Cys Gly Phe Phe Gly Met Tyr Asp Lys Ile Leu Leu Phe 
            100                 105                 110         


Arg His Asp Met Asn Ser Glu Asn Ile Leu Gln Leu Ile Thr Ser Ala 
        115                 120                 125             


Asp Glu Ile His Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Leu 
    130                 135                 140                 


Ala Thr Val Glu Asp Phe Gln Ile Arg Pro His Thr Leu Tyr Val His 
145                 150                 155                 160 


Ser Tyr Lys Ala Pro Thr Phe Cys Asp Tyr Cys Gly Glu Met Leu Trp 
                165                 170                 175     


Gly Leu Val Arg Gln Gly Leu Lys Cys Glu Gly Cys Gly Leu Asn Tyr 
            180                 185                 190         


His Lys Arg Cys Ala Phe Lys Ile Pro Asn Asn Cys Ser Gly Val Arg 
        195                 200                 205             


Lys Arg Arg Leu Ser Asn Val Ser Leu Pro Gly Pro Gly Leu Ser Val 
    210                 215                 220                 


Pro Arg Pro Leu Gln Pro Glu Tyr Val Ala Leu Pro Ser Glu Glu Ser 
225                 230                 235                 240 


His Val His Gln Glu Pro Ser Lys Arg Ile Pro Ser Trp Ser Gly Arg 
                245                 250                 255     


Pro Ile Trp Met Glu Lys Met Val Met Cys Arg Val Lys Val Pro His 
            260                 265                 270         


Thr Phe Ala Val His Ser Tyr Thr Arg Pro Thr Ile Cys Gln Tyr Cys 
        275                 280                 285             


Lys Arg Leu Leu Lys Gly Leu Phe Arg Gln Gly Met Gln Cys Lys Asp 
    290                 295                 300                 


Cys Lys Phe Asn Cys His Lys Arg Cys Ala Ser Lys Val Pro Arg Asp 
305                 310                 315                 320 


Cys Leu Gly Glu Val Thr Phe Asn Gly Glu Pro Ser Ser Leu Gly Thr 
                325                 330                 335     


Asp Thr Asp Ile Pro Met Asp Ile Asp Asn Asn Asp Ile Asn Ser Asp 
            340                 345                 350         


Ser Ser Arg Gly Leu Asp Asp Thr Glu Glu Pro Ser Pro Pro Glu Asp 
        355                 360                 365             


Lys Met Phe Phe Leu Asp Pro Ser Asp Leu Asp Val Glu Arg Asp Glu 
    370                 375                 380                 


Glu Ala Val Lys Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile Pro Leu 
385                 390                 395                 400 


Met Arg Val Val Gln Ser Ile Lys His Thr Lys Arg Lys Ser Ser Thr 
                405                 410                 415     


Met Val Lys Glu Gly Trp Met Val His Tyr Thr Ser Arg Asp Asn Leu 
            420                 425                 430         


Arg Lys Arg His Tyr Trp Arg Leu Asp Ser Lys Cys Leu Thr Leu Phe 
        435                 440                 445             


Gln Asn Glu Ser Gly Ser Lys Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
    450                 455                 460                 


Ile Leu Arg Ile Ser Ser Pro Arg Asp Phe Thr Asn Ile Ser Gln Gly 
465                 470                 475                 480 


Ser Asn Pro His Cys Phe Glu Ile Ile Thr Asp Thr Met Val Tyr Phe 
                485                 490                 495     


Val Gly Glu Asn Asn Gly Asp Ser Ser His Asn Pro Val Leu Ala Ala 
            500                 505                 510         


Thr Gly Val Gly Leu Asp Val Ala Gln Ser Trp Glu Lys Ala Ile Arg 
        515                 520                 525             


Gln Ala Leu Met Pro Val Thr Pro Gln Ala Ser Val Cys Thr Ser Pro 
    530                 535                 540                 


Gly Gln Gly Lys Asp His Lys Asp Leu Ser Thr Ser Ile Ser Val Ser 
545                 550                 555                 560 


Asn Cys Gln Ile Gln Glu Asn Val Asp Ile Ser Thr Val Tyr Gln Ile 
                565                 570                 575     


Phe Ala Asp Glu Val Leu Gly Ser Gly Gln Phe Gly Ile Val Tyr Gly 
            580                 585                 590         


Gly Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp 
        595                 600                 605             


Lys Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val 
    610                 615                 620                 


Ala Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu Glu Cys 
625                 630                 635                 640 


Met Phe Glu Thr Pro Glu Arg Val Phe Val Val Met Glu Lys Leu His 
                645                 650                 655     


Gly Asp Met Leu Glu Met Ile Leu Ser Ser Glu Lys Ser Arg Leu Pro 
            660                 665                 670         


Glu Arg Ile Thr Lys Phe Met Val Thr Gln Ile Leu Val Ala Leu Arg 
        675                 680                 685             


Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu Asn 
    690                 695                 700                 


Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys Asp 
705                 710                 715                 720 


Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser Val 
                725                 730                 735     


Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys Gly 
            740                 745                 750         


Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr Val 
        755                 760                 765             


Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp 
    770                 775                 780                 


Gln Ile Gln Asn Ala Ala Phe Met Tyr Pro Pro Asn Pro Trp Arg Glu 
785                 790                 795                 800 


Ile Ser Gly Glu Ala Ile Asp Leu Ile Asn Asn Leu Leu Gln Val Lys 
                805                 810                 815     


Met Arg Lys Arg Tyr Ser Val Asp Lys Ser Leu Ser His Pro Trp Leu 
            820                 825                 830         


Gln Asp Tyr Gln Thr Trp Leu Asp Leu Arg Glu Phe Glu Thr Arg Ile 
        835                 840                 845             


Gly Glu Arg Tyr Ile Thr His Glu Ser Asp Asp Ala Arg Trp Glu Ile 
    850                 855                 860                 


His Ala Tyr Thr His Asn Leu Val Tyr Pro Lys His Phe Ile Met Ala 
865                 870                 875                 880 


Pro Asn Pro Asp Asp Met Glu Glu Asp Pro 
                885                 890 


<210>  36
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  36
ggaagtacct ctctgagcgg ttggtgccgg gtataaaaga aggccgcgca gccacggctg       60

ctcacgacgc cgcggatccc gaagcctgtg tagcagtgag acatcagtga gtggctacag      120

caaaccaaac agcccagcag cccagcagcc cagccatgcg gcgcctcaca gtcgatgact      180

ttgaaatcgg gcgtcccctg ggcaagggga aatttgggaa tgtgtacctg gctcggctca      240

aggaaagcca tttcattgtg gccctgaagg ttctcttcaa gtcgcagata gagaaggaag      300

gactggagca ccagctgcgc cgggaaattg agatccaggc tcatctacaa caccccaata      360

tcctgcgcct gtataactat ttccatgatg cacgccgggt gtacctgatt ctggaatatg      420

ctccaagggg tgagctctac aaggagctgc agaaaagcga gaaattagat gaacagcgca      480

cagccacgat aatagaggag ttggcagatg ccctgaccta ctgccatgac aagaaagtga      540

ttcacagaga tattaagcca gagaacctgc tgctggggtt caggggtgag gtgaagattg      600

cagattttgg ctggtctgtg cacaccccct ccctgaggag gaagacaatg tgtgggacac      660

tggactactt gccgccagaa atgattgagg ggagaacata tgatgaaaag gtggatttgt      720

ggtgcattgg agtgctctgc tatgagctgc tggtgggata tccacccttt gagagcgcct      780

cccacagtga gacttacaga cgcatcctca aggtagatgt gaggtttcca ctatcaatgc      840

ctctgggggc ccgggacttg atttccaggc ttctcagata ccagcccttg gagagactgc      900

ccctggccca gatcctgaag cacccctggg ttcaggccca ctcccgaagg gtgctgcctc      960

cctgtgctca gatggcttcc tgagccctgt ctgcctctgt tccctttgtg tgtgttcagg     1020

gagctctcct ggctctgcca cctcatttgt ctttattttt ttctctttta agatgtaaga     1080

tgctaattaa taaaagctga atcatttcat accaaaaaaa aaaaa                     1125


<210>  37
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Glu Pro Leu Lys Glu Glu Asp Gly Glu Asp Gly Ser Ala Glu 
1               5                   10                  15      


Pro Pro Gly Pro Val Lys Ala Glu Pro Ala His Thr Ala Ala Ser Val 
            20                  25                  30          


Ala Ala Lys Asn Leu Ala Leu Leu Lys Ala Arg Ser Phe Asp Val Thr 
        35                  40                  45              


Phe Asp Val Gly Asp Glu Tyr Glu Ile Ile Glu Thr Ile Gly Asn Gly 
    50                  55                  60                  


Ala Tyr Gly Val Val Ser Ser Ala Arg Arg Arg Leu Thr Gly Gln Gln 
65                  70                  75                  80  


Val Ala Ile Lys Lys Ile Pro Asn Ala Phe Asp Val Val Thr Asn Ala 
                85                  90                  95      


Lys Arg Thr Leu Arg Glu Leu Lys Ile Leu Lys His Phe Lys His Asp 
            100                 105                 110         


Asn Ile Ile Ala Ile Lys Asp Ile Leu Arg Pro Thr Val Pro Tyr Gly 
        115                 120                 125             


Glu Phe Lys Ser Val Tyr Val Val Leu Asp Leu Met Glu Ser Asp Leu 
    130                 135                 140                 


His Gln Ile Ile His Ser Ser Gln Pro Leu Thr Leu Glu His Val Arg 
145                 150                 155                 160 


Tyr Phe Leu Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Met His Ser Ala 
                165                 170                 175     


Gln Val Ile His Arg Asp Leu Lys Pro Ser Asn Leu Leu Val Asn Glu 
            180                 185                 190         


Asn Cys Glu Leu Lys Ile Gly Asp Phe Gly Met Ala Arg Gly Leu Cys 
        195                 200                 205             


Thr Ser Pro Ala Glu His Gln Tyr Phe Met Thr Glu Tyr Val Ala Thr 
    210                 215                 220                 


Arg Trp Tyr Arg Ala Pro Glu Leu Met Leu Ser Leu His Glu Tyr Thr 
225                 230                 235                 240 


Gln Ala Ile Asp Leu Trp Ser Val Gly Cys Ile Phe Gly Glu Met Leu 
                245                 250                 255     


Ala Arg Arg Gln Leu Phe Pro Gly Lys Asn Tyr Val His Gln Leu Gln 
            260                 265                 270         


Leu Ile Met Met Val Leu Gly Thr Pro Ser Pro Ala Val Ile Gln Ala 
        275                 280                 285             


Val Gly Ala Glu Arg Val Arg Ala Tyr Ile Gln Ser Leu Pro Pro Arg 
    290                 295                 300                 


Gln Pro Val Pro Trp Glu Thr Val Tyr Pro Gly Ala Asp Arg Gln Ala 
305                 310                 315                 320 


Leu Ser Leu Leu Gly Arg Met Leu Arg Phe Glu Pro Ser Ala Arg Ile 
                325                 330                 335     


Ser Ala Ala Ala Ala Leu Arg His Pro Phe Leu Ala Lys Tyr His Asp 
            340                 345                 350         


Pro Asp Asp Glu Pro Asp Cys Ala Pro Pro Phe Asp Phe Ala Phe Asp 
        355                 360                 365             


Arg Glu Ala Leu Thr Arg Glu Arg Ile Lys Glu Ala Ile Val Ala Glu 
    370                 375                 380                 


Ile Glu Asp Phe His Ala Arg Arg Glu Gly Ile Arg Gln Gln Ile Arg 
385                 390                 395                 400 


Phe Gln Pro Ser Leu Gln Pro Val Ala Ser Glu Pro Gly Cys Pro Asp 
                405                 410                 415     


Val Glu Met Pro Ser Pro Trp Ala Pro Ser Gly Asp Cys Ala Met Glu 
            420                 425                 430         


Ser Pro Pro Pro Ala Pro Pro Pro Cys Pro Gly Pro Ala Pro Asp Thr 
        435                 440                 445             


Ile Asp Leu Thr Leu Gln Pro Pro Pro Pro Val Ser Glu Pro Ala Pro 
    450                 455                 460                 


Pro Lys Lys Asp Gly Ala Ile Ser Asp Asn Thr Lys Ala Ala Leu Lys 
465                 470                 475                 480 


Ala Ala Leu Leu Lys Ser Leu Arg Ser Arg Leu Arg Asp Gly Pro Ser 
                485                 490                 495     


Ala Pro Leu Glu Ala Pro Glu Pro Arg Lys Pro Val Thr Ala Gln Glu 
            500                 505                 510         


Arg Gln Arg Glu Arg Glu Glu Lys Arg Arg Arg Arg Gln Glu Arg Ala 
        515                 520                 525             


Lys Glu Arg Glu Lys Arg Arg Gln Glu Arg Glu Arg Lys Glu Arg Gly 
    530                 535                 540                 


Ala Gly Ala Ser Gly Gly Pro Ser Thr Asp Pro Leu Ala Gly Leu Val 
545                 550                 555                 560 


Leu Ser Asp Asn Asp Arg Ser Leu Leu Glu Arg Trp Thr Arg Met Ala 
                565                 570                 575     


Arg Pro Ala Ala Pro Ala Leu Thr Ser Val Pro Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Thr Pro Thr Pro Thr Pro Val Gln Pro Thr Ser Pro Pro Pro Gly 
        595                 600                 605             


Pro Val Ala Gln Pro Thr Gly Pro Gln Pro Gln Ser Ala Gly Ser Thr 
    610                 615                 620                 


Ser Gly Pro Val Pro Gln Pro Ala Cys Pro Pro Pro Gly Pro Ala Pro 
625                 630                 635                 640 


His Pro Thr Gly Pro Pro Gly Pro Ile Pro Val Pro Ala Pro Pro Gln 
                645                 650                 655     


Ile Ala Thr Ser Thr Ser Leu Leu Ala Ala Gln Ser Leu Val Pro Pro 
            660                 665                 670         


Pro Gly Leu Pro Gly Ser Ser Thr Pro Gly Val Leu Pro Tyr Phe Pro 
        675                 680                 685             


Pro Gly Leu Pro Pro Pro Asp Ala Gly Gly Ala Pro Gln Ser Ser Met 
    690                 695                 700                 


Ser Glu Ser Pro Asp Val Asn Leu Val Thr Gln Gln Leu Ser Lys Ser 
705                 710                 715                 720 


Gln Val Glu Asp Pro Leu Pro Pro Val Phe Ser Gly Thr Pro Lys Gly 
                725                 730                 735     


Ser Gly Ala Gly Tyr Gly Val Gly Phe Asp Leu Glu Glu Phe Leu Asn 
            740                 745                 750         


Gln Ser Phe Asp Met Gly Val Ala Asp Gly Pro Gln Asp Gly Gln Ala 
        755                 760                 765             


Asp Ser Ala Ser Leu Ser Ala Ser Leu Leu Ala Asp Trp Leu Glu Gly 
    770                 775                 780                 


His Gly Met Asn Pro Ala Asp Ile Glu Ser Leu Gln Arg Glu Ile Gln 
785                 790                 795                 800 


Met Asp Ser Pro Met Leu Leu Ala Asp Leu Pro Asp Leu Gln Asp Pro 
                805                 810                 815     


<210>  38
<211>  3949
<212>  DNA
<213>  Homo sapiens

<400>  38
ggtagtctgc ctgccgcagt ccgagcgccg cgctggggag agcgggtgtt tgaaggctcc       60

gcggaccggc actaggagcc gggggcgggt ccgtgaccct ccggctgctc ggagtgaaca      120

ggcggccagg aaagaagcgg gcctgaacac catgatccct ttggagaagc caggcagcgg      180

cggctcctcc ccaggcgcca cctcaggctc gggccgggca ggccggggtc tgagcgggcc      240

gtgccggccg ccgccgccgc cccaggcccg cgggctgctg acagagatac gcgccgtggt      300

gcgcaccgag cccttccagg acggctacag cctgtgcccg ggccgggagc tgggcagggg      360

gaaatttgca gtggtgagaa aatgtataaa gaaagattct gggaaagaat ttgctgcaaa      420

gttcatgaga aaaagaagaa aaggccaaga ttgtcggatg gaaataattc atgagattgc      480

tgtacttgaa ctagcacaag acaatccttg ggtcattaat ttacatgaag tttatgagac      540

tgcatcagaa atgatcttag ttctggaata tgctgctggg ggtgaaatct ttgaccagtg      600

tgttgcagac agagaagaag cctttaaaga aaaagatgtt caaagactta tgcgacagat      660

tttagaaggt gttcactttt tacacactcg tgatgtagtt catcttgatt tgaagcctca      720

gaatattctg ttgacaagtg aatctccatt gggtgacatt aagattgttg attttggcct      780

ttcaagaata ttgaagaaca gtgaagagct ccgagaaatt atgggtaccc ctgaatatgt      840

ggctcctgaa attcttagtt atgatcctat aagcatggca acagatatgt ggagcattgg      900

agtgttaaca tatgtcatgc ttacaggaat atcacctttc ttaggcaatg ataaacaaga      960

aacattctta aacatctcac agatgaattt aagttattct gaggaagaat ttgatgtttt     1020

gtctgagtcg gctgttgatt tcatcaggac acttttagtt aagaaacctg aagatcgagc     1080

cactgctgaa gaatgtctaa agcacccctg gttgacacag agcagtattc aagagccttc     1140

tttcaggatg gaaaaggcac tagaagaagc aaatgccctc caagaaggtc attctgtgcc     1200

tgaaattaat tcggataccg acaaatcaga aaccaaggaa tccattgtaa ccgaagagtt     1260

aattgtagtt acttcatata ctctaggaca atgcagacag tctgaaaaag agaaaatgga     1320

gcaaaaggcc atttccaaac gatttaaatt tgaggaacct ttgctacaag aaattccagg     1380

agaatttatc tactgagcaa tatttccctt tagaacttca agatttctac attgaaaatg     1440

ttaatattat ttatggacct ctggccaaat ggtacatgta ctggaagtgg ataaccagta     1500

tcacttacac aaacaaaaat aactttgtca aatttgtgga gttaggtgga agccagattt     1560

taaaagttgc caaccaggag atttaacagg tacagttacc cgtttcaatg ttatttttaa     1620

gaagggagat gttggcacct ttgaattcta catcctgttt ctccagaatg agaatttgtg     1680

tacaaagata tttgtattca ctttctttaa aaaatccaag taaaagtgcc aaaactacac     1740

ttctgtaaat ctcttgcatt attcatatgt gtatctatat ctgcataatg tttgttaatg     1800

tctactaaaa ttgctacttt ttcactttgg atttgttttt ggcaaaattt tagtctaaac     1860

agacatctaa attttcgaga cttagaataa cattcactaa agtttgataa tgtctttttt     1920

aaatattttc ttactgcttt atagtgactt gatttggttt ctgttgtgtt tttgcctaaa     1980

tactagtaac atatcagtga aaaaccctaa ttttttttct cttcaatgtc actagtaaga     2040

gaggtggtaa tttttcacct ctgaaattat tctgggttta ggtgtcagct cttgagctgc     2100

ttccctcatc acaccacact cacatgcatc tgttctctct cacactctat acccctgcca     2160

cttcctggca cctcccccca tgcttgtcat ttaattttgg ccacttgtag gtatcagtgt     2220

gatctgatca acactctggt taccttggtc agtgaaaaga tgctactata ttgcttttgt     2280

cccaaagtga gtaaaatccc ctagagcaga gagagagaga gagagagaga gtgtcttcat     2340

gccaaccaca gcctgtttct gctgagtttc ttatcagccc tcaagctatg ctaggaaaag     2400

ttataaaatg ccaaaatatt tataaacatt tactttgtcc ataaaaaatt tacattggat     2460

actctgtaag taggaggtac tttgtcccaa aaagatgtat aagaatgtac taatagtttt     2520

atttgattag gattgaacag ttcagttgta tctatgcccc acagtgacca gtaaagtcca     2580

attaaaatat ggaaatgtaa aagtgtatgc cgaatacctt aaagtaacta attatcctta     2640

cacacaaaag gctcagtgca ttaaatattt gcctatcacc tgtgtgctgt gtaccgtggc     2700

catgcctcgc tctgcactat gaacaactca gacctgtccc ttcacggtct gattagggtg     2760

tcacacaaag ctctctccct aacatggttt ctcaactgtc aaaatcatga aaatgacagc     2820

acctaaccac tattttaaag tatgtacagt aaatacccaa atgtgtgtaa atgtcataga     2880

catatacaaa gtcagtaatc tcacccagtc ctgctgtgtg aacctgtcaa agcacctggg     2940

agtgcccttt acaccattag gtgaaattca tcaggcactt cagacaacca ggttgcactg     3000

ttttctcact aaattggctt tatttataca gtttcctgga acctagcatt cctaaacaag     3060

ctccaaaatg cagaagaaga aattgtgcca cagtgataga gtttttaatg aatatccatg     3120

gccacagttt tgagtctcag gtaagtcttg gaagaagtta aacacagtat taggcaaata     3180

tttatctctc tgaaaaaata gggaggaggt gaccaggaaa aaataaccac tattgaatga     3240

cacgtttgta cttgatggat ctgtcatcaa gttttaaaat cagaatcatt tgggcttttt     3300

aaaaaccatt ttatactcgt aataaatata tttaatataa ttgctgtatt tgtgagaaag     3360

atctgttttc ttttagctgg ccacttcagt ttgctgcgta tctttagctg ctgttgtgct     3420

taaatactga gtcatagggt gcttttttaa gaggcccttc agaatatact tgtaaaggtg     3480

tattggcatt ttttggttta taagataaaa acagggcatg aagagccttc atagtattag     3540

gccaaataaa atctattaat aactgccagc tagctctaca cttatctaaa gctgttaatg     3600

ttcctttttt tctatcacca aatttataaa ggactaaaca gtactattga gtttactcgg     3660

tttataaatc cagttttaac tataattcaa caatattttg gtgtggtgaa acgttgttta     3720

tgaaatgtat aaaatgtata agttttaatc aactgggaaa tgatatttga ttgatcttgt     3780

gttttgttgt tttcaaatga aaactaggag gtaattaata cctttctcta gtagtggtat     3840

agaggaagga cagatgctca ttgttgaatc tcttaaattt ttccagctaa cctcagtttg     3900

gaagaaaaat gtattaaagg gttataaaga tcaaaaaaaa aaaaaaaaa                 3949


<210>  39
<211>  3352
<212>  DNA
<213>  Homo sapiens

<400>  39
accgcctccc aggccaggcg agcaggcggg tggctggggc gcctccacct cctcttccta       60

aagcggcgag gcgcagagga gcggcatcac tcgagcccag gtcccagcca ccaccactca      120

cagcgctcgg cgttcaggaa gaggagcagc agcggaggcg gctgcttcag cggcgggcgg      180

gcgccagaaa ggccccgatc gaaaagcctg ggagggccgc cgaactaccc ccggagggag      240

gagccagtcc gaacccaagg cgccaccgcc gcagaagcgg agcgaggcag cattcgcctc      300

catggcccac tcgccggtgg ctgtccaagt gcctgggatg cagaataaca tagctgatcc      360

agaagaactg ttcacaaaat tagagcgcat tgggaaaggc tcatttgggg aagttttcaa      420

aggaattgat aaccgtaccc agcaagtcgt tgctattaaa atcatagacc ttgaggaagc      480

cgaagatgaa atagaagaca ttcagcaaga aataactgtc ttgagtcaat gtgacagctc      540

atatgtaaca aaatactatg ggtcatattt aaaggggtct aaattatgga taataatgga      600

atacctgggc ggtggttcag cactggatct tcttcgagct ggtccatttg atgagttcca      660

gattgctacc atgctaaagg aaattttaaa aggtctggac tatctgcatt cagaaaagaa      720

aattcaccga gacataaaag ctgccaatgt cttgctctca gaacaaggag atgttaaact      780

tgctgatttt ggagttgctg gtcagctgac agatacacag attaaaagaa atacctttgt      840

gggaactcca ttttggatgg ctcctgaagt tattcaacag tcagcttatg actcaaaagc      900

tgacatttgg tcattgggaa ttactgctat tgaactagcc aagggagagc cacctaactc      960

cgatatgcat ccaatgagag ttctgtttct tattcccaaa aacaatcctc caactcttgt     1020

tggagacttt actaagtctt ttaaggagtt tattgatgct tgcctgaaca aagatccatc     1080

atttcgtcct acagcaaaag aacttctgaa acacaaattc attgtaaaaa attcaaagaa     1140

gacttcttat ctgactgaac tgatagatcg ttttaagaga tggaaggcag aaggacacag     1200

tgatgatgaa tctgattccg agggctctga ttcggaatct accagcaggg aaaacaatac     1260

tcatcctgaa tggagcttta ccaccgtacg aaagaagcct gatccaaaga aagtacagaa     1320

tggggcagag caagatcttg tgcaaaccct gagttgtttg tctatgataa tcacacctgc     1380

atttgctgaa cttaaacagc aggacgagaa taacgctagc aggaatcagg cgattgaaga     1440

actcgagaaa agtattgctg tggctgaagc cgcctgtccc ggcatcacag ataaaatggt     1500

gaagaaacta attgaaaaat ttcaaaagtg ttcagcagac gaatccccct aagaaactta     1560

ttattggctt ctgtttcata tggacccaga gagccccacc aaacctacgt caagattaac     1620

aatgcttaac ccatgagctc catgtgcctt ttggatcttt gcaacactga agatttggaa     1680

gaagctatta aactattttg tgatggcgtt tatcatttta tattttgaaa ggattatttt     1740

gtaaggaata acttttaata ctatagtttc acctgtattc tagtaaatgt tgagacaccg     1800

ttttgctttt aagtatccct atttcttaag ttacgaggat gaataccttt cacattttga     1860

tctttagttg actctacagt catgaaacat acaggtcttt caaagtcatt ctcaatattc     1920

agcttttgta aattatcaag cttcaaaaag cttttttttt taaaaaaaaa catgcatatt     1980

ctaaaaatga ctattggtgg ggaggtgtaa ataagtcata ccttcttaaa acagaaaatt     2040

taagtaaagt cttttaaatg aaacctgtaa aagtattgac tcttctacca agttggtatg     2100

atattccagg cagctcaatg attatcacat ttgagaccct gtgtttgaag catttacagg     2160

caatgtacag caacagaggt acctcttggt gtatagtatt tacattctct tttaggtaga     2220

agaggcaatt ttacccttat ttcacatggt tagaaattta aagcaagatc atttacccaa     2280

ggataggtgt ttggtaatgt tgaaggagtt agtctggctt catgttttac atcttcaact     2340

aaaatcccat actatctgct tggatttgga gagccaaaaa ataaagctga ttgtcatgtg     2400

attaaatatc tgatcaacag gtatgaatat aacttaaatc agcatatttt tgccatggta     2460

ataaattgtc ctataaacta tttatatatt tttgttcttc ataattatca ctaataagca     2520

tcagtttgtt gtttttaaaa ggatatttaa gtgagcattt tctagttcat atgaaaataa     2580

ccatagtaca ggatgatttc tgtccacaca aaggttaaat tagattgcac agttaatttt     2640

cacttatatt tatggtacta ttatgtgggt gatgcctttt tcttttaagc ccagtacata     2700

tattatgcct gcctaagttc tgaactgggg ctgtatttca gtagttgtag aattattgat     2760

atttagtttt gatagctaat gtttaattgt ttggatctgc acagtttggt ttttgcacaa     2820

aagtcattta aaaaaatctg agtaattgtc aaatattaaa agaaagatat tcttcctgta     2880

aggaatacag tttttagtca aagtggccat tacatcctct ttttaattta cataatacag     2940

atacttgaga aagttgttgt ggtgttgtat gccaagaaaa ttctttttat tggtgcctat     3000

attgtaacaa ttatttttaa tgcattgtat tttgaagtaa cggttcagtt aaatttttca     3060

cctgctgtgt aactgaaaca caattacagt ttataatcat ctgtagaagt ctggagataa     3120

ttttgcaact catgttatgg gttaaatgaa tatttttgta aaagtaaaag caacaaattt     3180

ataaattgat tatttgaaac tttacaacac aattgcatcc caaatacaaa ttgtattgct     3240

tattcattat agctattcgt cctgtaatct gtttctaggt gaagcatact ccagtgtttt     3300

aggggttttg aaaataaata tttaaatttc acagtcaaaa aaaaaaaaaa aa             3352


<210>  40
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asp Met Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Lys Asn Arg Glu Thr Gly Gln Leu Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Leu Glu Met Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Lys His Pro Asn Ile Val 
    50                  55                  60                  


Arg Leu Leu Asp Val Val His Asn Glu Arg Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Gln Asp Leu Lys Lys Tyr Met Asp Ser Thr Pro Gly 
                85                  90                  95      


Ser Glu Leu Pro Leu His Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Val Ser Phe Cys His Ser His Arg Val Ile His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Glu Leu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Leu Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Ser Lys Phe Tyr Thr Thr Ala Val Asp Ile Trp Ser Ile Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Lys Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Met Leu Gly Thr Pro Ser Glu 
    210                 215                 220                 


Asp Thr Trp Pro Gly Val Thr Gln Leu Pro Asp Tyr Lys Gly Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Thr Arg Lys Gly Leu Glu Glu Ile Val Pro Asn Leu Glu 
                245                 250                 255     


Pro Glu Gly Arg Asp Leu Leu Met Gln Leu Leu Gln Tyr Asp Pro Ser 
            260                 265                 270         


Gln Arg Ile Thr Ala Lys Thr Ala Leu Ala His Pro Tyr Phe Ser Ser 
        275                 280                 285             


Pro Glu Pro Ser Pro Ala Ala Arg Gln Tyr Val Leu Gln Arg Phe Arg 
    290                 295                 300                 


His 
305 


<210>  41
<211>  1845
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser 
1               5                   10                  15      


Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala 
            20                  25                  30          


Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala 
        35                  40                  45              


Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val 
    50                  55                  60                  


Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu 
65                  70                  75                  80  


Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val 
                85                  90                  95      


His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser 
            100                 105                 110         


Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala 
        115                 120                 125             


Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe 
    130                 135                 140                 


Ser Ala Pro Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro 
145                 150                 155                 160 


Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln 
                165                 170                 175     


Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val 
            180                 185                 190         


Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser 
        195                 200                 205             


Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn 
    210                 215                 220                 


Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly 
225                 230                 235                 240 


Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala 
                245                 250                 255     


Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg 
            260                 265                 270         


Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu 
        275                 280                 285             


Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly 
    290                 295                 300                 


Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser 
305                 310                 315                 320 


Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro 
                325                 330                 335     


Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val 
            340                 345                 350         


Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly 
        355                 360                 365             


Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr 
    370                 375                 380                 


Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn 
385                 390                 395                 400 


Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe 
                405                 410                 415     


Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys 
            420                 425                 430         


Phe Arg Cys Glu Gly Leu Ala Val Met Glu Val Ala Pro Ser Phe Ser 
        435                 440                 445             


Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly Gln Asp Phe Val Leu 
    450                 455                 460                 


Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg Ile Thr Trp Leu Leu 
465                 470                 475                 480 


Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr Cys Glu Ala Gly Val 
                485                 490                 495     


Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu Asp His Gly Thr Tyr 
            500                 505                 510         


Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val Ser Cys Ser Ala Trp 
        515                 520                 525             


Val Thr Val His Glu Lys Lys Ser Ser Arg Lys Ser Glu Tyr Leu Leu 
    530                 535                 540                 


Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile Phe Leu Gln Gly Leu 
545                 550                 555                 560 


Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val Thr Met Thr Val Gln 
                565                 570                 575     


Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp Leu His Asn Gly Asn 
            580                 585                 590         


Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu Gln Arg Gly Thr Gln 
        595                 600                 605             


His Ser Leu Cys Ile Gln Glu Val Phe Pro Glu Asp Thr Gly Thr Tyr 
    610                 615                 620                 


Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val Arg Thr Gln Ala Val 
625                 630                 635                 640 


Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln Pro Trp Phe Ile Ser 
                645                 650                 655     


Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln Ser Val Leu Ile Ser 
            660                 665                 670         


Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val His Trp Leu Arg Asp 
        675                 680                 685             


Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe Glu Val Leu Gln Asn 
    690                 695                 700                 


Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val Gln Pro Trp His Ala 
705                 710                 715                 720 


Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val Gly Glu Cys Ser Cys 
                725                 730                 735     


Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala Arg Ala Leu Pro Arg 
            740                 745                 750         


Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys Gly Gly Gly Val Gly 
        755                 760                 765             


Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser Leu Arg Pro Gly Trp 
    770                 775                 780                 


Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu Asp Gly Glu Asp Val 
785                 790                 795                 800 


Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg Gln His Thr Glu Glu 
                805                 810                 815     


Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp Phe Arg Asp Leu Leu 
            820                 825                 830         


Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu Asp Asp Leu Lys Glu 
        835                 840                 845             


Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn Leu Gln Arg Gln Val 
    850                 855                 860                 


Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys Val His Ser Pro Gln 
865                 870                 875                 880 


Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys Gly Thr Ser Lys Thr 
                885                 890                 895     


Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro Ala Thr Pro Asp Phe 
            900                 905                 910         


Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro Ala Glu Asn Gly Ser 
        915                 920                 925             


Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val Glu Ser Ser Lys Pro 
    930                 935                 940                 


Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys Pro Val Gly Asn Ala 
945                 950                 955                 960 


Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Ala Glu 
                965                 970                 975     


Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp Glu Asn Leu Lys Ser 
            980                 985                 990         


Ala Ser Lys Glu Glu Leu Lys Lys  Asp Val Lys Asn Asp  Val Asn Cys 
        995                 1000                 1005             


Lys Arg  Gly His Ala Gly Thr  Thr Asp Asn Glu Lys  Arg Ser Glu 
    1010                 1015                 1020             


Ser Gln  Gly Thr Ala Pro Ala  Phe Lys Gln Lys Leu  Gln Asp Val 
    1025                 1030                 1035             


His Val  Ala Glu Gly Lys Lys  Leu Leu Leu Gln Cys  Gln Val Ser 
    1040                 1045                 1050             


Ser Asp  Pro Pro Ala Thr Ile  Ile Trp Thr Leu Asn  Gly Lys Thr 
    1055                 1060                 1065             


Leu Lys  Thr Thr Lys Phe Ile  Ile Leu Ser Gln Glu  Gly Ser Leu 
    1070                 1075                 1080             


Cys Ser  Val Ser Ile Glu Lys  Ala Leu Pro Glu Asp  Arg Gly Leu 
    1085                 1090                 1095             


Tyr Lys  Cys Val Ala Lys Asn  Asp Ala Gly Gln Ala  Glu Cys Ser 
    1100                 1105                 1110             


Cys Gln  Val Thr Val Asp Asp  Ala Pro Ala Ser Glu  Asn Thr Lys 
    1115                 1120                 1125             


Ala Pro  Glu Met Lys Ser Arg  Arg Pro Lys Ser Ser  Leu Pro Pro 
    1130                 1135                 1140             


Val Leu  Gly Thr Glu Ser Asp  Ala Thr Val Lys Lys  Lys Pro Ala 
    1145                 1150                 1155             


Pro Lys  Thr Pro Pro Lys Ala  Ala Met Pro Pro Gln  Ile Ile Gln 
    1160                 1165                 1170             


Phe Pro  Glu Asp Gln Lys Val  Arg Ala Gly Glu Ser  Val Glu Leu 
    1175                 1180                 1185             


Phe Gly  Lys Val Thr Gly Thr  Gln Pro Ile Thr Cys  Thr Trp Met 
    1190                 1195                 1200             


Lys Phe  Arg Lys Gln Ile Gln  Glu Ser Glu His Met  Lys Val Glu 
    1205                 1210                 1215             


Asn Ser  Glu Asn Gly Ser Lys  Leu Thr Ile Leu Ala  Ala Arg Gln 
    1220                 1225                 1230             


Glu His  Cys Gly Cys Tyr Thr  Leu Leu Val Glu Asn  Lys Leu Gly 
    1235                 1240                 1245             


Ser Arg  Gln Ala Gln Val Asn  Leu Thr Val Val Asp  Lys Pro Asp 
    1250                 1255                 1260             


Pro Pro  Ala Gly Thr Pro Cys  Ala Ser Asp Ile Arg  Ser Ser Ser 
    1265                 1270                 1275             


Leu Thr  Leu Ser Trp Tyr Gly  Ser Ser Tyr Asp Gly  Gly Ser Ala 
    1280                 1285                 1290             


Val Gln  Ser Tyr Ser Ile Glu  Ile Trp Asp Ser Ala  Asn Lys Thr 
    1295                 1300                 1305             


Trp Lys  Glu Leu Ala Thr Cys  Arg Ser Thr Ser Phe  Asn Val Gln 
    1310                 1315                 1320             


Asp Leu  Leu Pro Asp His Glu  Tyr Lys Phe Arg Val  Arg Ala Ile 
    1325                 1330                 1335             


Asn Val  Tyr Gly Thr Ser Glu  Pro Ser Gln Glu Ser  Glu Leu Thr 
    1340                 1345                 1350             


Thr Val  Gly Glu Lys Pro Glu  Glu Pro Lys Asp Glu  Val Glu Val 
    1355                 1360                 1365             


Ser Asp  Asp Asp Glu Lys Glu  Pro Glu Val Asp Tyr  Arg Thr Val 
    1370                 1375                 1380             


Thr Ile  Asn Thr Glu Gln Lys  Val Ser Asp Phe Tyr  Asp Ile Glu 
    1385                 1390                 1395             


Glu Arg  Leu Gly Ser Gly Lys  Phe Gly Gln Val Phe  Arg Leu Val 
    1400                 1405                 1410             


Glu Lys  Lys Thr Arg Lys Val  Trp Ala Gly Lys Phe  Phe Lys Ala 
    1415                 1420                 1425             


Tyr Ser  Ala Lys Glu Lys Glu  Asn Ile Arg Gln Glu  Ile Ser Ile 
    1430                 1435                 1440             


Met Asn  Cys Leu His His Pro  Lys Leu Val Gln Cys  Val Asp Ala 
    1445                 1450                 1455             


Phe Glu  Glu Lys Ala Asn Ile  Val Met Val Leu Glu  Ile Val Ser 
    1460                 1465                 1470             


Gly Gly  Glu Leu Phe Glu Arg  Ile Ile Asp Glu Asp  Phe Glu Leu 
    1475                 1480                 1485             


Thr Glu  Arg Glu Cys Ile Lys  Tyr Met Arg Gln Ile  Ser Glu Gly 
    1490                 1495                 1500             


Val Glu  Tyr Ile His Lys Gln  Gly Ile Val His Leu  Asp Leu Lys 
    1505                 1510                 1515             


Pro Glu  Asn Ile Met Cys Val  Asn Lys Thr Gly Thr  Arg Ile Lys 
    1520                 1525                 1530             


Leu Ile  Asp Phe Gly Leu Ala  Arg Arg Leu Glu Asn  Ala Gly Ser 
    1535                 1540                 1545             


Leu Lys  Val Leu Phe Gly Thr  Pro Glu Phe Val Ala  Pro Glu Val 
    1550                 1555                 1560             


Ile Asn  Tyr Glu Pro Ile Gly  Tyr Ala Thr Asp Met  Trp Ser Ile 
    1565                 1570                 1575             


Gly Val  Ile Cys Tyr Ile Leu  Val Ser Gly Leu Ser  Pro Phe Met 
    1580                 1585                 1590             


Gly Asp  Asn Asp Asn Glu Thr  Leu Ala Asn Val Thr  Ser Ala Thr 
    1595                 1600                 1605             


Trp Asp  Phe Asp Asp Glu Ala  Phe Asp Glu Ile Ser  Asp Asp Ala 
    1610                 1615                 1620             


Lys Asp  Phe Ile Ser Asn Leu  Leu Lys Lys Asp Met  Lys Asn Arg 
    1625                 1630                 1635             


Leu Asp  Cys Thr Gln Cys Leu  Gln His Pro Trp Leu  Met Lys Asp 
    1640                 1645                 1650             


Thr Lys  Asn Met Glu Ala Lys  Lys Leu Ser Lys Asp  Arg Met Lys 
    1655                 1660                 1665             


Lys Tyr  Met Ala Arg Arg Lys  Trp Gln Lys Thr Gly  Asn Ala Val 
    1670                 1675                 1680             


Arg Ala  Ile Gly Arg Leu Ser  Ser Met Ala Met Ile  Ser Gly Leu 
    1685                 1690                 1695             


Ser Gly  Arg Lys Ser Ser Thr  Gly Ser Pro Thr Ser  Pro Leu Asn 
    1700                 1705                 1710             


Ala Glu  Lys Leu Glu Ser Glu  Glu Asp Val Ser Gln  Ala Phe Leu 
    1715                 1720                 1725             


Glu Ala  Val Ala Glu Glu Lys  Pro His Val Lys Pro  Tyr Phe Ser 
    1730                 1735                 1740             


Lys Thr  Ile Arg Asp Leu Glu  Val Val Glu Gly Ser  Ala Ala Arg 
    1745                 1750                 1755             


Phe Asp  Cys Lys Ile Glu Gly  Tyr Pro Asp Pro Glu  Val Val Trp 
    1760                 1765                 1770             


Phe Lys  Asp Asp Gln Ser Ile  Arg Glu Ser Arg His  Phe Gln Ile 
    1775                 1780                 1785             


Asp Tyr  Asp Glu Asp Gly Asn  Cys Ser Leu Ile Ile  Ser Asp Val 
    1790                 1795                 1800             


Cys Gly  Asp Asp Asp Ala Lys  Tyr Thr Cys Lys Ala  Val Asn Ser 
    1805                 1810                 1815             


Leu Gly  Glu Ala Thr Cys Thr  Ala Glu Leu Ile Val  Glu Thr Met 
    1820                 1825                 1830             


Glu Glu  Gly Glu Gly Glu Gly  Glu Glu Glu Glu Glu  
    1835                 1840                 1845 


<210>  42
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Gln Ser Asp Asp Arg Asp Ser Lys Arg Asp Ser Leu Glu Glu 
1               5                   10                  15      


Gly Glu Leu Arg Asp His Arg Met Glu Ile Thr Ile Arg Asn Ser Pro 
            20                  25                  30          


Tyr Arg Arg Glu Asp Ser Met Glu Asp Arg Gly Glu Glu Asp Asp Ser 
        35                  40                  45              


Leu Ala Ile Lys Pro Pro Gln Gln Met Ser Arg Lys Glu Lys Val His 
    50                  55                  60                  


His Arg Lys Asp Glu Lys Arg Lys Glu Lys Lys His Ala Arg Val Lys 
65                  70                  75                  80  


Glu Lys Glu Arg Glu His Glu Arg Arg Lys Arg His Arg Glu Glu Gln 
                85                  90                  95      


Asp Lys Ala Arg Arg Glu Trp Glu Arg Gln Lys Arg Arg Glu Met Ala 
            100                 105                 110         


Arg Glu His Ser Arg Arg Glu Arg Asp Arg Leu Glu Gln Leu Glu Arg 
        115                 120                 125             


Lys Arg Glu Arg Glu Arg Lys Met Arg Glu Gln Gln Lys Glu Gln Arg 
    130                 135                 140                 


Glu Gln Lys Glu Arg Glu Arg Arg Ala Glu Glu Arg Arg Lys Glu Arg 
145                 150                 155                 160 


Glu Ala Arg Arg Glu Val Ser Ala His His Arg Thr Met Arg Glu Asp 
                165                 170                 175     


Tyr Ser Asp Lys Val Lys Ala Ser His Trp Ser Arg Ser Pro Pro Arg 
            180                 185                 190         


Pro Pro Arg Glu Arg Phe Glu Leu Gly Asp Gly Arg Lys Pro Val Lys 
        195                 200                 205             


Glu Glu Lys Met Glu Glu Arg Asp Leu Leu Ser Asp Leu Gln Asp Ile 
    210                 215                 220                 


Ser Asp Ser Glu Arg Lys Thr Ser Ser Ala Glu Ser Ser Ser Ala Glu 
225                 230                 235                 240 


Ser Gly Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                245                 250                 255     


Glu Glu Gly Ser Thr Ser Glu Glu Ser Glu Glu Glu Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Thr Gly Ser Asn Ser Glu Glu Ala Ser Glu 
        275                 280                 285             


Gln Ser Ala Glu Glu Val Ser Glu Glu Glu Met Ser Glu Asp Glu Glu 
    290                 295                 300                 


Arg Glu Asn Glu Asn His Leu Leu Val Val Pro Glu Ser Arg Phe Asp 
305                 310                 315                 320 


Arg Asp Ser Gly Glu Ser Glu Glu Ala Glu Glu Glu Val Gly Glu Gly 
                325                 330                 335     


Thr Pro Gln Ser Ser Ala Leu Thr Glu Gly Asp Tyr Val Pro Asp Ser 
            340                 345                 350         


Pro Ala Leu Ser Pro Ile Glu Leu Lys Gln Glu Leu Pro Lys Tyr Leu 
        355                 360                 365             


Pro Ala Leu Gln Gly Cys Arg Ser Val Glu Glu Phe Gln Cys Leu Asn 
    370                 375                 380                 


Arg Ile Glu Glu Gly Thr Tyr Gly Val Val Tyr Arg Ala Lys Asp Lys 
385                 390                 395                 400 


Lys Thr Asp Glu Ile Val Ala Leu Lys Arg Leu Lys Met Glu Lys Glu 
                405                 410                 415     


Lys Glu Gly Phe Pro Ile Thr Ser Leu Arg Glu Ile Asn Thr Ile Leu 
            420                 425                 430         


Lys Ala Gln His Pro Asn Ile Val Thr Val Arg Glu Ile Val Val Gly 
        435                 440                 445             


Ser Asn Met Asp Lys Ile Tyr Ile Val Met Asn Tyr Val Glu His Asp 
    450                 455                 460                 


Leu Lys Ser Leu Met Glu Thr Met Lys Gln Pro Phe Leu Pro Gly Glu 
465                 470                 475                 480 


Val Lys Thr Leu Met Ile Gln Leu Leu Arg Gly Val Lys His Leu His 
                485                 490                 495     


Asp Asn Trp Ile Leu His Arg Asp Leu Lys Thr Ser Asn Leu Leu Leu 
            500                 505                 510         


Ser His Ala Gly Ile Leu Lys Val Gly Asp Phe Gly Leu Ala Arg Glu 
        515                 520                 525             


Tyr Gly Ser Pro Leu Lys Ala Tyr Thr Pro Val Val Val Thr Leu Trp 
    530                 535                 540                 


Tyr Arg Ala Pro Glu Leu Leu Leu Gly Ala Lys Glu Tyr Ser Thr Ala 
545                 550                 555                 560 


Val Asp Met Trp Ser Val Gly Cys Ile Phe Gly Glu Leu Leu Thr Gln 
                565                 570                 575     


Lys Pro Leu Phe Pro Gly Lys Ser Glu Ile Asp Gln Ile Asn Lys Val 
            580                 585                 590         


Phe Lys Asp Leu Gly Thr Pro Ser Glu Lys Ile Trp Pro Gly Tyr Ser 
        595                 600                 605             


Glu Leu Pro Ala Val Lys Lys Met Thr Phe Ser Glu His Pro Tyr Asn 
    610                 615                 620                 


Asn Leu Arg Lys Arg Phe Gly Ala Leu Leu Ser Asp Gln Gly Phe Asp 
625                 630                 635                 640 


Leu Met Asn Lys Phe Leu Thr Tyr Phe Pro Gly Arg Arg Ile Ser Ala 
                645                 650                 655     


Glu Asp Gly Leu Lys His Glu Tyr Phe Arg Glu Thr Pro Leu Pro Ile 
            660                 665                 670         


Asp Pro Ser Met Phe Pro Thr Trp Pro Ala Lys Ser Glu Gln Gln Arg 
        675                 680                 685             


Val Lys Arg Gly Thr Ser Pro Arg Pro Pro Glu Gly Gly Leu Gly Tyr 
    690                 695                 700                 


Ser Gln Leu Gly Asp Asp Asp Leu Lys Glu Thr Gly Phe His Leu Thr 
705                 710                 715                 720 


Thr Thr Asn Gln Gly Ala Ser Ala Ala Gly Pro Gly Phe Ser Leu Lys 
                725                 730                 735     


Phe 
    


<210>  43
<211>  4919
<212>  DNA
<213>  Homo sapiens

<400>  43
gagcaagcgg agcggccgtc gcccaagcca agccgcgctg ccaaccctcc cgcccgcccg       60

cgctcctgtc cgccgtgtct agcagcgggg cccagcatgg tcatggcgga tggcccgagg      120

cacttgcagc gcgggccggt ccgggtgggg ttctacgaca tcgagggcac gctgggcaag      180

ggcaacttcg ctgtggtgaa gctggggcgg caccggatca ccaagacgga ggtggcaata      240

aaaataatcg ataagtctca gctggatgca gtgaaccttg agaaaatcta ccgagaagta      300

caaataatga aaatgttaga ccaccctcac ataatcaaac tttatcaggt aatggagacc      360

aaaagtatgt tgtaccttgt gacagaatat gccaaaaatg gagaaatttt tgactatctt      420

gctaatcatg gccggttaaa tgagtctgaa gccaggcgaa aattctggca aatcctgtct      480

gctgttgatt attgtcatgg tcggaagatt gtgcaccgtg acctcaaagc tgaaaatctc      540

ctgctggata acaacatgaa tatcaaaata gcagatttcg gttttggaaa tttctttaaa      600

agtggtgaac tgctggcaac atggtgtggc agcccccctt atgcagcccc agaagtcttt      660

gaagggcagc agtatgaagg accacagctg gacatctgga gtatgggagt tgttctttat      720

gtccttgtct gtggagctct gccctttgat ggaccgactc ttccaatttt gaggcagagg      780

gttctggaag gaagattccg gattccgtat ttcatgtcag aagattgcga gcaccttatc      840

cgaaggatgt tggtcctaga cccatccaaa cggctaacca tagcccaaat caaggagcat      900

aaatggatgc tcatagaagt tcctgtccag agacctgttc tctatccaca agagcaagaa      960

aatgagccat ccatcgggga gtttaatgag caggttctgc gactgatgca cagccttgga     1020

atagatcagc agaaaaccat tgagtctttg cagaacaaga gctataacca ctttgctgcc     1080

atttatttct tgttggtgga gcgcctgaaa tcacatcgga gcagtttccc agtggagcag     1140

agacttgatg gccgccagcg tcggcctagc accattgctg agcaaacagt tgccaaggca     1200

cagactgtgg ggctcccagt gaccatgcat tcaccgaaca tgaggctgct gcgatctgcc     1260

ctcctccccc aggcatccaa cgtggaggcc ttttcatttc cagcatctgg ctgtcaggcg     1320

gaagctgcat tcatggaaga agagtgtgtg gacactccaa aggtcaatgg ctgtctgctt     1380

gaccctgtgc ctcctgtcct ggtgcggaag ggatgccagt cactgcccag caacatgatg     1440

gagacctcca ttgacgaagg gctggagaca gaaggagagg ccgaggaaga ccccgctcat     1500

gcctttgagg catttcagtc cacacgcagc gggcagagac ggcacactct gtcagaagtg     1560

accaatcaac tggtcgtgat gcctggggca gggaaaattt tctccatgaa tgacagcccc     1620

tcccttgaca gtgtggactc tgagtatgat atggggtctg ttcagaggga cctgaacttt     1680

ctggaagaca acccttccct taaggacatc atgttagcca atcagccttc accccgcatg     1740

acatctccct tcataagcct gagacctacc aacccagcca tgcaggctct gagctcccag     1800

aaacgagagg tccacaacag gtctccagtg agcttcagag agggccgcag agcatcagat     1860

acctccctca cccagggaat tgtagcattt agacaacatc ttcagaatct ggctagaacc     1920

aaaggaattc tagagttgaa caaagtgcag ttgttgtatg aacaaatagg accggaggca     1980

gaccctaacc tggcgccggc ggctcctcag ctccaggacc ttgctagcag ctgccctcag     2040

gaagaagttt ctcagcagca ggaaagcgtc tccactctcc ctgccagcgt gcatccccag     2100

ctgtccccac ggcagagcct ggagacccag tacctgcagc acagactcca gaagcccagc     2160

cttctgtcaa aggcccagaa cacctgtcag ctttattgca aagaaccacc gcggagcctt     2220

gagcagcagc tgcaggaaca taggctccag cagaagcgac tctttcttca gaagcagtct     2280

caactgcagg cctattttaa tcagatgcag atagcagaga gctcctaccc acagccaagt     2340

cagcagctgc cccttccccg ccaggagact ccaccgcctt ctcagcaggc cccaccgttc     2400

agcctgaccc agcccctgag ccccgtcctg gagccttcct ccgagcagat gcaatacagc     2460

cctttcctca gccagtacca agagatgcag cttcagcccc tgccctccac ttccggtccc     2520

cgggctgctc ctcctctgcc cacgcagcta cagcagcagc agccgccacc gccaccaccc     2580

cctccaccac cacgacagcc aggagctgcc ccagccccct tacagttctc ctatcagact     2640

tgtgagctgc caagcgctgc ttcccctgcg ccagactatc ccactccctg tcagtatcct     2700

gtggatggag cccagcagag cgacctaacg gggccagact gtcccagaag cccaggactg     2760

caagaggccc cctccagcta cgacccacta gccctctctg agctacctgg actctttgat     2820

tgtgaaatgc tagacgctgt ggatccacaa cacaacgggt atgtcctggt gaattagtct     2880

cagcacagga attgaggtgg gtcaggtgaa ggaagagtgt atgttcctat ttttattcca     2940

gccttttaaa tttaaagctt attttcttgc cctctcccta acggggagaa atcgagccac     3000

ccaactggaa tcagagggtc tggctggggt ggatgttgct tcctcctggt tctgccccac     3060

cacaaagttt tctgtggcaa gtgctggaac atagttgtag gctgaggctc ctgcccttcg     3120

gtcgagtgga gcaagctctc gagggcagca ctgacaaatg tgttcctaag aagacattca     3180

gacccaggtg ttatgcagga ttacatccgt ttattatcaa gggcaacctt ggtgaaagca     3240

gaaagggtgt gtgctattgc atatatatgg gggaaaaggc aatatatttt tcactgaagc     3300

tgagcaacca catattgcta caaggcaaat caagaagaca tcaggaaatc agatgcacag     3360

gaaataaagg aaagctgtgc tttgtcattg aatcctaagt tcttagctgc tgatgcaagt     3420

tgtcccccaa ggccatcaca aagcagtggg gcatgagctg tgtttcaggg gccactaaat     3480

aacagctggt actgacccca gaaaccgcct tcatctccat tcggaagcag gtgacacacc     3540

ccttcagaag gtgccctggg ttgccgagtg tcagaatata ctcaggactc cagaggtgtc     3600

acacgtggaa ctgacaggag acccgccacc gtggaggcag ggggcaagaa actcaagaac     3660

gcatcaagag caccagccct gggccaggga agacaggctc ttcctgcagt ttctcgtgga     3720

cactgctggc ttgcgggcag tcggtctcca gggtacctgt tgtctctttt ccgatgtaat     3780

aactactttg accttacact atatgttgct agtagtttat tgagctttgt atatttggac     3840

agtttcatat agggcttaga gattttaagg acatgataaa tgaacttttc tgtcccatgt     3900

gaagtggtag tgcggtgcct ttcccccaga tcatgcttta attctttctt ttctgtagaa     3960

accaacagtt tccatttatg tcaatgctaa atccaaagtc acttcagagt ttgttttcca     4020

ccatgtggga atcagcattc ttaatttcgt taaagttttg acttgtaatg aaatgttcaa     4080

gtattacagc aatattcaaa gaaagaacca cagatgtgtt aaccatttaa gcagatcatc     4140

tgccaaacat tatattacta ataaaactta accaacactt acaattcagt catcaaagta     4200

agtaaaaatt agatgctaca gctagctaac tgtatcccta gaaatgatga ataatttgcc     4260

atttggacag ttaacatcca ggtgttacaa agtcagtgtt aattctaaag atgatcattt     4320

ctgcccttta gaatggcttg tcccatcagc agatgaatgt gttaagcaca aagcatcttc     4380

cttaaagcac aaagagaggg actaactgat gctgcatcta gaaaacacct ttaagttgcc     4440

tttcctcttt gtagttagcg ttcaggcagg tgacgtgtgg aaagtctagg gggttccatt     4500

ctggccatgc gagcccagct cctaccaacg tcggtaactt gagcagtccc tgttgctggc     4560

cagagactgc ctggtcgcca gcgctcacca tgggtgccag gatgcttcgc agaggcactg     4620

tgctcacggt tggacttggt gtcagtggga aagggcagtg tggggactgt catttttgtg     4680

atttaataac acacagtgaa aatccaggaa gaatgaatta agcttcttct gggagttgtt     4740

tattcctgct cgtgcttaag attgatgatt tcgtgaaata aagaacatca tttcatttaa     4800

gagatcattt cattaagatc tctaatctgt tttgagtctt tacaaaatag ccagttataa     4860

aatggggctt gatttgttta gactgaagga agacgttttc ccaaaatata ctacagaag      4919


<210>  44
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Tyr Asp Phe Lys Ala Lys Leu Ala Ala Glu Arg Glu Arg Val 
1               5                   10                  15      


Glu Asp Leu Phe Glu Tyr Glu Gly Cys Lys Val Gly Arg Gly Thr Tyr 
            20                  25                  30          


Gly His Val Tyr Lys Ala Arg Arg Lys Asp Gly Lys Asp Glu Lys Glu 
        35                  40                  45              


Tyr Ala Leu Lys Gln Ile Glu Gly Thr Gly Ile Ser Met Ser Ala Cys 
    50                  55                  60                  


Arg Glu Ile Ala Leu Leu Arg Glu Leu Lys His Pro Asn Val Ile Ala 
65                  70                  75                  80  


Leu Gln Lys Val Phe Leu Ser His Ser Asp Arg Lys Val Trp Leu Leu 
                85                  90                  95      


Phe Asp Tyr Ala Glu His Asp Leu Trp His Ile Ile Lys Phe His Arg 
            100                 105                 110         


Ala Ser Lys Ala Asn Lys Lys Pro Met Gln Leu Pro Arg Ser Met Val 
        115                 120                 125             


Lys Ser Leu Leu Tyr Gln Ile Leu Asp Gly Ile His Tyr Leu His Ala 
    130                 135                 140                 


Asn Trp Val Leu His Arg Asp Leu Lys Pro Ala Asn Ile Leu Val Met 
145                 150                 155                 160 


Gly Glu Gly Pro Glu Arg Gly Arg Val Lys Ile Ala Asp Met Gly Phe 
                165                 170                 175     


Ala Arg Leu Phe Asn Ser Pro Leu Lys Pro Leu Ala Asp Leu Asp Pro 
            180                 185                 190         


Val Val Val Thr Phe Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Ala 
        195                 200                 205             


Arg His Tyr Thr Lys Ala Ile Asp Ile Trp Ala Ile Gly Cys Ile Phe 
    210                 215                 220                 


Ala Glu Leu Leu Thr Ser Glu Pro Ile Phe His Cys Arg Gln Glu Asp 
225                 230                 235                 240 


Ile Lys Thr Ser Asn Pro Phe His His Asp Gln Leu Asp Arg Ile Phe 
                245                 250                 255     


Ser Val Met Gly Phe Pro Ala Asp Lys Asp Trp Glu Asp Ile Arg Lys 
            260                 265                 270         


Met Pro Glu Tyr Pro Thr Leu Gln Lys Asp Phe Arg Arg Thr Thr Tyr 
        275                 280                 285             


Ala Asn Ser Ser Leu Ile Lys Tyr Met Glu Lys His Lys Val Lys Pro 
    290                 295                 300                 


Asp Ser Lys Val Phe Leu Leu Leu Gln Lys Leu Leu Thr Met Asp Pro 
305                 310                 315                 320 


Thr Lys Arg Ile Thr Ser Glu Gln Ala Leu Gln Asp Pro Tyr Phe Gln 
                325                 330                 335     


Glu Asp Pro Leu Pro Thr Leu Asp Val Phe Ala Gly Cys Gln Ile Pro 
            340                 345                 350         


Tyr Pro Lys Arg Glu Phe Leu Asn Glu Asp Asp Pro Glu Glu Lys Gly 
        355                 360                 365             


Asp Lys Asn Gln Gln Gln Gln Gln Asn Gln His Gln Gln Pro Thr Ala 
    370                 375                 380                 


Pro Pro Gln Gln Ala Ala Ala Pro Pro Gln Ala Pro Pro Pro Gln Gln 
385                 390                 395                 400 


Asn Ser Thr Gln Thr Asn Gly Thr Ala Gly Gly Ala Gly Ala Gly Val 
                405                 410                 415     


Gly Gly Thr Gly Ala Gly Leu Gln His Ser Gln Asp Ser Ser Leu Asn 
            420                 425                 430         


Gln Val Pro Pro Asn Lys Lys Pro Arg Leu Gly Pro Ser Gly Ala Asn 
        435                 440                 445             


Ser Gly Gly Pro Val Met Pro Ser Asp Tyr Gln His Ser Ser Ser Arg 
    450                 455                 460                 


Leu Asn Tyr Gln Ser Ser Val Gln Gly Ser Ser Gln Ser Gln Ser Thr 
465                 470                 475                 480 


Leu Gly Tyr Ser Ser Ser Ser Gln Gln Ser Ser Gln Tyr His Pro Ser 
                485                 490                 495     


His Gln Ala His Arg Tyr 
            500         


<210>  45
<211>  2204
<212>  DNA
<213>  Homo sapiens

<400>  45
gagcggtgcg gaggctctgc tcggatcgag gtctgcagcg cagcttcggg agcatgagtg       60

ctgcagtgac tgcagggaag ctggcacggg caccggccga ccctgggaaa gccggggtcc      120

ccggagttgc agctcccgga gctccggcgg cggctccacc ggcgaaagag atcccggagg      180

tcctagtgga cccacgcagc cggcggcgct atgtgcgggg ccgctttttg ggcaagggcg      240

gctttgccaa gtgcttcgag atctcggacg cggacaccaa ggaggtgttc gcgggcaaga      300

ttgtgcctaa gtctctgctg ctcaagccgc accagaggga gaagatgtcc atggaaatat      360

ccattcaccg cagcctcgcc caccagcacg tcgtaggatt ccacggcttt ttcgaggaca      420

acgacttcgt gttcgtggtg ttggagctct gccgccggag gtctctcctg gagctgcaca      480

agaggaggaa agccctgact gagcctgagg cccgatacta cctacggcaa attgtgcttg      540

gctgccagta cctgcaccga aaccgagtta ttcatcgaga cctcaagctg ggcaaccttt      600

tcctgaatga agatctggag gtgaaaatag gggattttgg actggcaacc aaagtcgaat      660

atgacgggga gaggaagaag accctgtgtg ggactcctaa ttacatagct cccgaggtgc      720

tgagcaagaa agggcacagt ttcgaggtgg atgtgtggtc cattgggtgt atcatgtata      780

ccttgttagt gggcaaacca ccttttgaga cttcttgcct aaaagagacc tacctccgga      840

tcaagaagaa tgaatacagt attcccaagc acatcaaccc cgtggccgcc tccctcatcc      900

agaagatgct tcagacagat cccactgccc gcccaaccat taacgagctg cttaatgacg      960

agttctttac ttctggctat atccctgccc gtctccccat cacctgcctg accattccac     1020

caaggttttc gattgctccc agcagcctgg accccagcaa ccggaagccc ctcacagtcc     1080

tcaataaagg cttggagaac cccctgcctg agcgtccccg ggaaaaagaa gaaccagtgg     1140

ttcgagagac aggtgaggtg gtcgactgcc acctcagtga catgctgcag cagctgcaca     1200

gtgtcaatgc ctccaagccc tcggagcgtg ggctggtcag gcaagaggag gctgaggatc     1260

ctgcctgcat ccccatcttc tgggtcagca agtgggtgga ctattcggac aagtacggcc     1320

ttgggtatca gctctgtgat aacagcgtgg gggtgctctt caatgactca acacgcctca     1380

tcctctacaa tgatggtgac agcctgcagt acatagagcg tgacggcact gagtcctacc     1440

tcaccgtgag ttcccatccc aactccttga tgaagaagat caccctcctt aaatatttcc     1500

gcaattacat gagcgagcac ttgctgaagg caggtgccaa catcacgccg cgcgaaggtg     1560

atgagctcgc ccggctgccc tacctacgga cctggttccg cacccgcagc gccatcatcc     1620

tgcacctcag caacggcagc gtgcagatca acttcttcca ggatcacacc aagctcatct     1680

tgtgcccact gatggcagcc gtgacctaca tcgacgagaa gcgggacttc cgcacatacc     1740

gcctgagtct cctggaggag tacggctgct gcaaggagct ggccagccgg ctccgctacg     1800

cccgcactat ggtggacaag ctgctgagct cacgctcggc cagcaaccgt ctcaaggcct     1860

cctaatagct gccctcccct ccggactggt gccctcctca ctcccacctg catctggggc     1920

ccatactggt tggctcccgc ggtgccatgt ctgcagtgtg ccccccagcc ccggtggctg     1980

ggcagagctg catcatcctt gcaggtgggg gttgctgtgt aagttatttt tgtacatgtt     2040

cgggtgtggg ttctacagcc ttgtccccct ccccctcaac cccaccatat gaattgtaca     2100

gaatatttct attgaattcg gaactgtcct ttccttggct ttatgcacat taaacagatg     2160

tgaatattca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      2204


<210>  46
<211>  5718
<212>  DNA
<213>  Homo sapiens

<400>  46
ctcctgaggc tgccagcagc cagcagtgac tgcccgccct atctgggacc caggatcgct       60

ctgtgagcaa cttggagcca gagaggagat caacaaggag gaggagagag ccggcccctc      120

agccctgctg cccagcagca gcctgtgctc gccctgccca acgcagacag ccagacccag      180

ggcggcccct ctggcggctc tgctcctccc gaaggatgct tggggagtga ggcgaagctg      240

ggccgctcct ctcccctaca gcagccccct tcctccatcc ctctgttctc ctgagccttc      300

aggagcctgc accagtcctg cctgtccttc tactcagctg ttacccactc tgggaccagc      360

agtctttctg ataactggga gagggcagta aggaggactt cctggagggg gtgactgtcc      420

agagcctgga actgtgccca caccagaagc catcagcagc aaggacacca tgcggcttcc      480

gggtgcgatg ccagctctgg ccctcaaagg cgagctgctg ttgctgtctc tcctgttact      540

tctggaacca cagatctctc agggcctggt cgtcacaccc ccggggccag agcttgtcct      600

caatgtctcc agcaccttcg ttctgacctg ctcgggttca gctccggtgg tgtgggaacg      660

gatgtcccag gagcccccac aggaaatggc caaggcccag gatggcacct tctccagcgt      720

gctcacactg accaacctca ctgggctaga cacgggagaa tacttttgca cccacaatga      780

ctcccgtgga ctggagaccg atgagcggaa acggctctac atctttgtgc cagatcccac      840

cgtgggcttc ctccctaatg atgccgagga actattcatc tttctcacgg aaataactga      900

gatcaccatt ccatgccgag taacagaccc acagctggtg gtgacactgc acgagaagaa      960

aggggacgtt gcactgcctg tcccctatga tcaccaacgt ggcttttctg gtatctttga     1020

ggacagaagc tacatctgca aaaccaccat tggggacagg gaggtggatt ctgatgccta     1080

ctatgtctac agactccagg tgtcatccat caacgtctct gtgaacgcag tgcagactgt     1140

ggtccgccag ggtgagaaca tcaccctcat gtgcattgtg atcgggaatg aggtggtcaa     1200

cttcgagtgg acataccccc gcaaagaaag tgggcggctg gtggagccgg tgactgactt     1260

cctcttggat atgccttacc acatccgctc catcctgcac atccccagtg ccgagttaga     1320

agactcgggg acctacacct gcaatgtgac ggagagtgtg aatgaccatc aggatgaaaa     1380

ggccatcaac atcaccgtgg ttgagagcgg ctacgtgcgg ctcctgggag aggtgggcac     1440

actacaattt gctgagctgc atcggagccg gacactgcag gtagtgttcg aggcctaccc     1500

accgcccact gtcctgtggt tcaaagacaa ccgcaccctg ggcgactcca gcgctggcga     1560

aatcgccctg tccacgcgca acgtgtcgga gacccggtat gtgtcagagc tgacactggt     1620

tcgcgtgaag gtggcagagg ctggccacta caccatgcgg gccttccatg aggatgctga     1680

ggtccagctc tccttccagc tacagatcaa tgtccctgtc cgagtgctgg agctaagtga     1740

gagccaccct gacagtgggg aacagacagt ccgctgtcgt ggccggggca tgccccagcc     1800

gaacatcatc tggtctgcct gcagagacct caaaaggtgt ccacgtgagc tgccgcccac     1860

gctgctgggg aacagttccg aagaggagag ccagctggag actaacgtga cgtactggga     1920

ggaggagcag gagtttgagg tggtgagcac actgcgtctg cagcacgtgg atcggccact     1980

gtcggtgcgc tgcacgctgc gcaacgctgt gggccaggac acgcaggagg tcatcgtggt     2040

gccacactcc ttgcccttta aggtggtggt gatctcagcc atcctggccc tggtggtgct     2100

caccatcatc tcccttatca tcctcatcat gctttggcag aagaagccac gttacgagat     2160

ccgatggaag gtgattgagt ctgtgagctc tgacggccat gagtacatct acgtggaccc     2220

catgcagctg ccctatgact ccacgtggga gctgccgcgg gaccagcttg tgctgggacg     2280

caccctcggc tctggggcct ttgggcaggt ggtggaggcc acggctcatg gcctgagcca     2340

ttctcaggcc acgatgaaag tggccgtcaa gatgcttaaa tccacagccc gcagcagtga     2400

gaagcaagcc cttatgtcgg agctgaagat catgagtcac cttgggcccc acctgaacgt     2460

ggtcaacctg ttgggggcct gcaccaaagg aggacccatc tatatcatca ctgagtactg     2520

ccgctacgga gacctggtgg actacctgca ccgcaacaaa cacaccttcc tgcagcacca     2580

ctccgacaag cgccgcccgc ccagcgcgga gctctacagc aatgctctgc ccgttgggct     2640

ccccctgccc agccatgtgt ccttgaccgg ggagagcgac ggtggctaca tggacatgag     2700

caaggacgag tcggtggact atgtgcccat gctggacatg aaaggagacg tcaaatatgc     2760

agacatcgag tcctccaact acatggcccc ttacgataac tacgttccct ctgcccctga     2820

gaggacctgc cgagcaactt tgatcaacga gtctccagtg ctaagctaca tggacctcgt     2880

gggcttcagc taccaggtgg ccaatggcat ggagtttctg gcctccaaga actgcgtcca     2940

cagagacctg gcggctagga acgtgctcat ctgtgaaggc aagctggtca agatctgtga     3000

ctttggcctg gctcgagaca tcatgcggga ctcgaattac atctccaaag gcagcacctt     3060

tttgccttta aagtggatgg ctccggagag catcttcaac agcctctaca ccaccctgag     3120

cgacgtgtgg tccttcggga tcctgctctg ggagatcttc accttgggtg gcacccctta     3180

cccagagctg cccatgaacg agcagttcta caatgccatc aaacggggtt accgcatggc     3240

ccagcctgcc catgcctccg acgagatcta tgagatcatg cagaagtgct gggaagagaa     3300

gtttgagatt cggcccccct tctcccagct ggtgctgctt ctcgagagac tgttgggcga     3360

aggttacaaa aagaagtacc agcaggtgga tgaggagttt ctgaggagtg accacccagc     3420

catccttcgg tcccaggccc gcttgcctgg gttccatggc ctccgatctc ccctggacac     3480

cagctccgtc ctctatactg ccgtgcagcc caatgagggt gacaacgact atatcatccc     3540

cctgcctgac cccaaacccg aggttgctga cgagggccca ctggagggtt cccccagcct     3600

agccagctcc accctgaatg aagtcaacac ctcctcaacc atctcctgtg acagccccct     3660

ggagccccag gacgaaccag agccagagcc ccagcttgag ctccaggtgg agccggagcc     3720

agagctggaa cagttgccgg attcggggtg ccctgcgcct cgggcggaag cagaggatag     3780

cttcctgtag ggggctggcc cctaccctgc cctgcctgaa gctccccccc tgccagcacc     3840

cagcatctcc tggcctggcc tgaccgggct tcctgtcagc caggctgccc ttatcagctg     3900

tccccttctg gaagctttct gctcctgacg tgttgtgccc caaaccctgg ggctggctta     3960

ggaggcaaga aaactgcagg ggccgtgacc agccctctgc ctccagggag gccaactgac     4020

tctgagccag ggttccccca gggaactcag ttttcccata tgtaagatgg gaaagttagg     4080

cttgatgacc cagaatctag gattctctcc ctggctgaca ggtggggaga ccgaatccct     4140

ccctgggaag attcttggag ttactgaggt ggtaaattaa cttttttctg ttcagccagc     4200

tacccctcaa ggaatcatag ctctctcctc gcacttttat ccacccagga gctagggaag     4260

agaccctagc ctccctggct gctggctgag ctagggccta gccttgagca gtgttgcctc     4320

atccagaaga aagccagtct cctccctatg atgccagtcc ctgcgttccc tggcccgagc     4380

tggtctgggg ccattaggca gcctaattaa tgctggaggc tgagccaagt acaggacacc     4440

cccagcctgc agcccttgcc cagggcactt ggagcacacg cagccatagc aagtgcctgt     4500

gtccctgtcc ttcaggccca tcagtcctgg ggctttttct ttatcaccct cagtcttaat     4560

ccatccacca gagtctagaa ggccagacgg gccccgcatc tgtgatgaga atgtaaatgt     4620

gccagtgtgg agtggccacg tgtgtgtgcc agtatatggc cctggctctg cattggacct     4680

gctatgaggc tttggaggaa tccctcaccc tctctgggcc tcagtttccc cttcaaaaaa     4740

tgaataagtc ggacttatta actctgagtg ccttgccagc actaacattc tagagtattc     4800

caggtggttg cacatttgtc cagatgaagc aaggccatat accctaaact tccatcctgg     4860

gggtcagctg ggctcctggg agattccaga tcacacatca cactctgggg actcaggaac     4920

catgcccctt ccccaggccc ccagcaagtc tcaagaacac agctgcacag gccttgactt     4980

agagtgacag ccggtgtcct ggaaagcccc cagcagctgc cccagggaca tgggaagacc     5040

acgggacctc tttcactacc cacgatgacc tccgggggta tcctgggcaa aagggacaaa     5100

gagggcaaat gagatcacct cctgcagccc accactccag cacctgtgcc gaggtctgcg     5160

tcgaagacag aatggacagt gaggacagtt atgtcttgta aaagacaaga agcttcagat     5220

gggtacccca agaaggatgt gagaggtggg cgctttggag gtttgcccct cacccaccag     5280

ctgccccatc cctgaggcag cgctccatgg gggtatggtt ttgtcactgc ccagacctag     5340

cagtgacatc tcattgtccc cagcccagtg ggcattggag gtgccagggg agtcagggtt     5400

gtagccaaga cgcccccgca cggggagggt tgggaagggg gtgcaggaag ctcaacccct     5460

ctgggcacca accctgcatt gcaggttggc accttacttc cctgggatcc ccagagttgg     5520

tccaaggagg gagagtgggt tctcaatacg gtaccaaaga tataatcacc taggtttaca     5580

aatattttta ggactcacgt taactcacat ttatacagca gaaatgctat tttgtatgct     5640

gttaagtttt tctatctgtg tacttttttt taagggaaag attttaatat taaacctggt     5700

gcttctcact cacaaaaa                                                   5718


<210>  47
<211>  3679
<212>  DNA
<213>  Homo sapiens

<400>  47
ccctcccctc ccgatcctca tccccttgcc ctcccccagc ccagggactt ttccggaaag       60

tttttatttt ccgtctgggc tctcggagaa agaagctcct ggctcagcgg ctgcaaaact      120

ttcctgctgc cgcgccgcca gcccccgccc tccgctgccc ggccctgcgc cccgccgagc      180

gatgagcgcc cctccggtcc tgcggccgcc cagtccgctg ctgcccgtgg cggcggcagc      240

tgccgcagcg gccgccgcac tggtcccagg gtccgggccc gggcccgcgc cgttcttggc      300

tcctgtcgcg gccccggtcg ggggcatctc gttccatctg cagatcggcc tgagccgtga      360

gccggtgctg ctgctgcagg actcgtccgg ggactacagc ctggcgcacg tccgcgagat      420

ggcttgctcc attgtcgacc agaagttccc tgaatgtggt ttctacggaa tgtatgataa      480

gatcctgctt tttcgccatg accctacctc tgaaaacatc cttcagctgg tgaaagcggc      540

cagtgatatc caggaaggcg atcttattga agtggtcttg tcagcttccg ccacctttga      600

agactttcag attcgtcccc acgctctctt tgttcattca tacagagctc cagctttctg      660

tgatcactgt ggagaaatgc tgtgggggct ggtacgtcaa ggtcttaaat gtgaagggtg      720

tggtctgaat taccataaga gatgtgcatt taaaataccc aacaattgca gcggtgtgag      780

gcggagaagg ctctcaaacg tttccctcac tggggtcagc accatccgca catcatctgc      840

tgaactctct acaagtgccc ctgatgagcc ccttctgcaa aaatcaccat cagagtcgtt      900

tattggtcga gagaagaggt caaattctca atcatacatt ggacgaccaa ttcaccttga      960

caagattttg atgtctaaag ttaaagtgcc gcacacattt gtcatccact cctacacccg     1020

gcccacagtg tgccagtact gcaagaagct tctgaagggg cttttcaggc agggcttgca     1080

gtgcaaagat tgcagattca actgccataa acgttgtgca ccgaaagtac caaacaactg     1140

ccttggcgaa gtgaccatta atggagattt gcttagccct ggggcagagt ctgatgtggt     1200

catggaagaa gggagtgatg acaatgatag tgaaaggaac agtgggctca tggatgatat     1260

ggaagaagca atggtccaag atgcagagat ggcaatggca gagtgccaga acgacagtgg     1320

cgagatgcaa gatccagacc cagaccacga ggacgccaac agaaccatca gtccatcaac     1380

aagcaacaat atcccactca tgagggtagt gcagtctgtc aaacacacga agaggaaaag     1440

cagcacagtc atgaaagaag gatggatggt ccactacacc agcaaggaca cgctgcggaa     1500

acggcactat tggagattgg atagcaaatg tattaccctc tttcagaatg acacaggaag     1560

caggtactac aaggaaattc ctttatctga aattttgtct ctggaaccag taaaaacttc     1620

agctttaatt cctaatgggg ccaatcctca ttgtttcgaa atcactacgg caaatgtagt     1680

gtattatgtg ggagaaaatg tggtcaatcc ttccagccca tcaccaaata acagtgttct     1740

caccagtggc gttggtgcag atgtggccag gatgtgggag atagccatcc agcatgccct     1800

tatgcccgtc attcccaagg gctcctccgt gggtacagga accaacttgc acagagatat     1860

ctctgtgagt atttcagtat caaattgcca gattcaagaa aatgtggaca tcagcacagt     1920

atatcagatt tttcctgatg aagtactggg ttctggacag tttggaattg tttatggagg     1980

aaaacatcgt aaaacaggaa gagatgtagc tattaaaatc attgacaaat tacgatttcc     2040

aacaaaacaa gaaagccagc ttcgtaatga ggttgcaatt ctacagaacc ttcatcaccc     2100

tggtgttgta aatttggagt gtatgtttga gacgcctgaa agagtgtttg ttgttatgga     2160

aaaactccat ggagacatgc tggaaatgat cttgtcaagt gaaaagggca ggttgccaga     2220

gcacataacg aagtttttaa ttactcagat actcgtggct ttgcggcacc ttcattttaa     2280

aaatatcgtt cactgtgacc tcaaaccaga aaatgtgttg ctagcctcag ctgatccttt     2340

tcctcaggtg aaactttgtg attttggttt tgcccggatc attggagaga agtctttccg     2400

gaggtcagtg gtgggtaccc ccgcttacct ggctcctgag gtcctaagga acaagggcta     2460

caatcgctct ctagacatgt ggtctgttgg ggtcatcatc tatgtaagcc taagcggcac     2520

attcccattt aatgaagatg aagacataca cgaccaaatt cagaatgcag ctttcatgta     2580

tccaccaaat ccctggaagg aaatatctca tgaagccatt gatcttatca acaatttgct     2640

gcaagtaaaa atgagaaagc gctacagtgt ggataagacc ttgagccacc cttggctaca     2700

ggactatcag acctggttag atttgcgaga gctggaatgc aaaatcgggg agcgctacat     2760

cacccatgaa agtgatgacc tgaggtggga gaagtatgca ggcgagcagg ggctgcagta     2820

ccccacacac ctgatcaatc caagtgctag ccacagtgac actcctgaga ctgaagaaac     2880

agaaatgaaa gccctcggtg agcgtgtcag catcctctga gttccatctc ctataatctg     2940

tcaaaacact gtggaactaa taaatacata cggtcaggtt taacatttgc cttgcagaac     3000

tgccattatt ttctgtcaga tgagaacaaa gctgttaaac tgttagcact gttgatgtat     3060

ctgagttgcc aagacaaatc aacagaagca tttgtatttt gtgtgaccaa ctgtgttgta     3120

ttaacaaaag ttccctgaaa cacgaaactt gttattgtga atgattcatg ttatatttaa     3180

tgcattaaac ctgtctccac tgtgcctttg caaatcagtg tttttcttac tggagcttca     3240

ttttggtaag agacagaatg tatctgtgaa gtagttctgt ttggtgtgtc ccattggtgt     3300

tgtcattgta aacaaactct tgaagagtcg attatttcca gtgttctatg aacaactcca     3360

aaacccatgt gggaaaaaaa tgaatgagga gggtagggaa taaaatccta agacacaaat     3420

gcatgaacaa gttttaatgt atagttttga atcctttgcc tgcctggtgt gcctcagtat     3480

atttaaactc aagacaatgc acctagctgt gcaagaccta gtgctcttaa gcctaaatgc     3540

cttagaaatg taaactgcca tatataacag atacatttcc ctctttctta taatactctg     3600

ttgtactatg gaaaatcagc tgctcagcaa cctttcacct ttgtgtattt ttcaataata     3660

aaaaatattc ttgtcaaaa                                                  3679


<210>  48
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Lys Gly Asp Cys Ile Ala Ser Val Tyr Gly Tyr Asp Leu 
1               5                   10                  15      


Gly Gly Arg Phe Val Asp Phe Gln Pro Leu Gly Phe Gly Val Asn Gly 
            20                  25                  30          


Leu Val Leu Ser Ala Val Asp Ser Arg Ala Cys Arg Lys Val Ala Val 
        35                  40                  45              


Lys Lys Ile Ala Leu Ser Asp Ala Arg Ser Met Lys His Ala Leu Arg 
    50                  55                  60                  


Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
65                  70                  75                  80  


Tyr Glu Val Leu Gly Pro Lys Gly Thr Asp Leu Gln Gly Glu Leu Phe 
                85                  90                  95      


Lys Phe Ser Val Ala Tyr Ile Val Gln Glu Tyr Met Glu Thr Asp Leu 
            100                 105                 110         


Ala Arg Leu Leu Glu Gln Gly Thr Leu Ala Glu Glu His Ala Lys Leu 
        115                 120                 125             


Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ala Asn Ile Phe Ile Ser Thr Glu 
145                 150                 155                 160 


Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg Ile Val Asp 
                165                 170                 175     


Gln His Tyr Ser His Lys Gly Tyr Leu Ser Glu Gly Leu Val Thr Lys 
            180                 185                 190         


Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn Tyr Thr Lys 
        195                 200                 205             


Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Leu Ala Glu Met Leu Thr 
    210                 215                 220                 


Gly Arg Met Leu Phe Ala Gly Ala His Glu Leu Glu Gln Met Gln Leu 
225                 230                 235                 240 


Ile Leu Glu Thr Ile Pro Val Ile Arg Glu Glu Asp Lys Asp Glu Leu 
                245                 250                 255     


Leu Arg Val Met Pro Ser Phe Val Ser Ser Thr Trp Glu Val Lys Arg 
            260                 265                 270         


Pro Leu Arg Lys Leu Leu Pro Glu Val Asn Ser Glu Ala Ile Asp Phe 
        275                 280                 285             


Leu Glu Lys Ile Leu Thr Phe Asn Pro Met Asp Arg Leu Thr Ala Glu 
    290                 295                 300                 


Met Gly Leu Gln His Pro Tyr Met Ser Pro Tyr Ser Cys Pro Glu Asp 
305                 310                 315                 320 


Glu Pro Thr Ser Gln His Pro Phe Arg Ile Glu Asp Glu Ile Asp Asp 
                325                 330                 335     


Ile Val Leu Met Ala Ala Asn Gln Ser Gln Leu Ser Asn Trp Asp Thr 
            340                 345                 350         


Cys Ser Ser Arg Tyr Pro Val Ser Leu Ser Ser Asp Leu Glu Trp Arg 
        355                 360                 365             


Pro Asp Arg Cys Gln Asp Ala Ser Glu Val Gln Arg Asp Pro Arg Ala 
    370                 375                 380                 


Gly Ser Ala Pro Leu Ala Glu Asp Val Gln Val Asp Pro Arg Lys Asp 
385                 390                 395                 400 


Ser His Ser Ser Ser Glu Arg Phe Leu Glu Gln Ser His Ser Ser Met 
                405                 410                 415     


Glu Arg Ala Phe Glu Ala Asp Tyr Gly Arg Ser Cys Asp Tyr Lys Val 
            420                 425                 430         


Gly Ser Pro Ser Tyr Leu Asp Lys Leu Leu Trp Arg Asp Asn Lys Pro 
        435                 440                 445             


His His Tyr Ser Glu Pro Lys Leu Ile Leu Asp Leu Ser His Trp Lys 
    450                 455                 460                 


Gln Ala Ala Gly Ala Pro Pro Thr Ala Thr Gly Leu Ala Asp Thr Gly 
465                 470                 475                 480 


Ala Arg Glu Asp Glu Pro Ala Ser Leu Phe Leu Glu Ile Ala Gln Trp 
                485                 490                 495     


Val Lys Ser Thr Gln Gly Gly Pro Glu His Ala Ser Pro Pro Ala Asp 
            500                 505                 510         


Asp Pro Glu Arg Arg Leu Ser Ala Ser Pro Pro Gly Arg Pro Ala Pro 
        515                 520                 525             


Val Asp Gly Gly Ala Ser Pro Gln Phe Asp Leu Asp Val Phe Ile Ser 
    530                 535                 540                 


Arg Ala Leu Lys Leu Cys Thr Lys Pro Glu Asp Leu Pro Asp Asn Lys 
545                 550                 555                 560 


Leu Gly Asp Leu Asn Gly Ala Cys Ile Pro Glu His Pro Gly Asp Leu 
                565                 570                 575     


Val Gln Thr Glu Ala Phe Ser Lys Glu Arg Trp 
            580                 585         


<210>  49
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Ser Asn Cys Thr Ser Thr Thr Ala Val Ala Val Ala Pro Leu 
1               5                   10                  15      


Ser Ala Ser Lys Thr Lys Thr Lys Lys Lys His Phe Val Cys Gln Lys 
            20                  25                  30          


Val Lys Leu Phe Arg Ala Ser Glu Pro Ile Leu Ser Val Leu Met Trp 
        35                  40                  45              


Gly Val Asn His Thr Ile Asn Glu Leu Ser Asn Val Pro Val Pro Val 
    50                  55                  60                  


Met Leu Met Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp 
65                  70                  75                  80  


Asn His Leu Phe Asn Lys Glu Asn Leu Pro Ser Arg Phe Lys Phe Lys 
                85                  90                  95      


Glu Tyr Cys Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile 
            100                 105                 110         


Asp Asp Gln Asp Tyr Gln Asn Ser Val Thr Arg Ser Ala Pro Ile Asn 
        115                 120                 125             


Ser Asp Ser Gln Gly Arg Cys Gly Thr Arg Phe Leu Thr Thr Tyr Asp 
    130                 135                 140                 


Arg Arg Phe Val Ile Lys Thr Val Ser Ser Glu Asp Val Ala Glu Met 
145                 150                 155                 160 


His Asn Ile Leu Lys Lys Tyr His Gln Phe Ile Val Glu Cys His Gly 
                165                 170                 175     


Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Thr Val Asp 
            180                 185                 190         


Gly Val Glu Thr Tyr Met Val Val Thr Arg Asn Val Phe Ser His Arg 
        195                 200                 205             


Leu Thr Val His Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg 
    210                 215                 220                 


Glu Ala Ser Asp Lys Glu Lys Ala Lys Asp Leu Pro Thr Phe Lys Asp 
225                 230                 235                 240 


Asn Asp Phe Leu Asn Glu Gly Gln Lys Leu His Val Gly Glu Glu Ser 
                245                 250                 255     


Lys Lys Asn Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Ala 
            260                 265                 270         


Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val 
        275                 280                 285             


Asp Arg Ala Glu Gln Glu Glu Met Glu Val Glu Glu Arg Ala Glu Asp 
    290                 295                 300                 


Glu Glu Cys Glu Asn Asp Gly Val Gly Gly Asn Leu Leu Cys Ser Tyr 
305                 310                 315                 320 


Gly Thr Pro Pro Asp Ser Pro Gly Asn Leu Leu Ser Phe Pro Arg Phe 
                325                 330                 335     


Phe Gly Pro Gly Glu Phe Asp Pro Ser Val Asp Val Tyr Ala Met Lys 
            340                 345                 350         


Ser His Glu Ser Ser Pro Lys Lys Glu Val Tyr Phe Met Ala Ile Ile 
        355                 360                 365             


Asp Ile Leu Thr Pro Tyr Asp Thr Lys Lys Lys Ala Ala His Ala Ala 
    370                 375                 380                 


Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr Val Asn Pro 
385                 390                 395                 400 


Glu Gln Tyr Ser Lys Arg Phe Asn Glu Phe Met Ser Asn Ile Leu Thr 
                405                 410                 415     


<210>  50
<211>  2030
<212>  DNA
<213>  Homo sapiens

<400>  50
gcgcgatggc ggcggctcct ttaggcagct gaaaggggat ttaggcccgg aagatccgag       60

tccatccgcg gcggggagag ggcaagcggg accggtaggg gccggagcag cggcggcggc      120

gctcggactg tcccatccgc cccgtattga ggcgctggga gcggcggggc gacaggaaag      180

cgatggtgaa agcggggccg tgaggggggc ggagccggga gccggacccg cagtagcggc      240

agcagcggcg ccgcctccca gagttcagac ccaggaagcg gccgggaggg caggagcgaa      300

tcgggccgcc gccgccatgg agctgagagt cgggaacagg taccggctgg gccggaagat      360

cggcagcggc tccttcggag acatctatct cggtacggac attgctgcag gagaagaggt      420

tgccatcaag cttgaatgtg tcaaaaccaa acaccctcag ctccacattg agagcaaaat      480

ctacaagatg atgcagggag gagtgggcat ccccaccatc agatggtgcg gggcagaggg      540

ggactacaac gtcatggtga tggagctgct ggggccaagc ctggaggacc tcttcaactt      600

ctgctccagg aaattcagcc tcaaaaccgt cctgctgctt gctgaccaaa tgatcagtcg      660

catcgaatac attcattcaa agaacttcat ccaccgggat gtgaagccag acaacttcct      720

catgggcctg gggaagaagg gcaacctggt gtacatcatc gacttcgggc tggccaagaa      780

gtaccgggat gcacgcaccc accagcacat cccctatcgt gagaacaaga acctcacggg      840

gacggcgcgg tacgcctcca tcaacacgca ccttggaatt gaacaatccc gaagagatga      900

cttggagtct ctgggctacg tgctaatgta cttcaacctg ggctctctcc cctggcaggg      960

gctgaaggct gccaccaaga gacagaaata cgaaaggatt agcgagaaga aaatgtccac     1020

ccccatcgaa gtgttgtgta aaggctaccc ttccgaattt gccacatacc tgaatttctg     1080

ccgttccttg cgttttgacg acaagcctga ctactcgtac ctgcggcagc ttttccggaa     1140

tctgttccat cgccagggct tctcctatga ctacgtgttc gactggaaca tgctcaaatt     1200

tggtgccagc cgggccgccg atgacgccga gcgggagcgc agggaccgag aggagcggct     1260

gagacactcg cggaacccgg ctacccgcgg cctcccttcc acagcctccg gccgcctgcg     1320

ggggacgcag gaagtggctc cccccacacc cctcacccct acctcacaca cggctaacac     1380

ctccccccgg cccgtctccg gcatggagag agagcggaaa gtgagtatgc ggctgcaccg     1440

cggggccccc gtcaacatct cctcgtccga cctcacaggc cgacaagata cctctcgcat     1500

gtccacctca cagattcctg gtcgggtggc ttccagtggt cttcagtctg tcgtgcaccg     1560

atgagaactc tccttattgc tgtgaagggc agacaatgca tggctgatct actctgttac     1620

caatggcttt actagtgaca cgtcccccgg tctaggatcg aaatgttaac accgggagct     1680

ctccaggcca ctcacccagc gacgctcgtg ggggaaacat actaaacgga cagactccaa     1740

gagctgccac cgctggggct gcactgcggc cccccacgtg aactcggttg taacggggct     1800

gggaagaaaa gcagagagag aattgcagag aatcagactc cttttccagg gcctcagctc     1860

cctccagtgg tggccgccct gtactccctg acgattccac tgtaactacc aatcttctac     1920

ttggttaaga cagttttgta tcattttgct aaaaattatt ggcttaaatc tgtgtaaaga     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2030


<210>  51
<211>  3199
<212>  DNA
<213>  Homo sapiens

<400>  51
gccgaagtgc tagtgccgcg gcggcggcgg cggacggccc agccggagcg cgaggggctc       60

gggggggcgc ggcggttcgg gtcgcagagc cagggacccc aggacccggg aggcggcgca      120

gccggggccg ccggaggagc gcgggtgacc tggcggcggc gagatgccgc tcgcccagct      180

caaggagccc tggccgctca tggagctagt gcctctggac ccggagaatg gacagacctc      240

aggggaagaa gctggacttc agccgtccaa ggatgagggc gtcctcaagg agatctccat      300

cacgcaccac gtcaaggctg gctctgagaa ggctgatcca tcccatttcg agctcctcaa      360

ggttctgggc cagggatcct ttggcaaagt cttcctggtg cggaaagtca cccggcctga      420

cagtgggcac ctgtatgcta tgaaggtgct gaagaaggca acgctgaaag tacgtgaccg      480

cgtccggacc aagatggaga gagacatcct ggctgatgta aatcacccat tcgtggtgaa      540

gctgcactat gccttccaga ccgagggcaa gctctatctc attctggact tcctgcgtgg      600

tggggacctc ttcacccggc tctcaaaaga ggtgatgttc acggaggagg atgtgaagtt      660

ttacctggcc gagctggctc tgggcctgga tcacctgcac agcctgggta tcatttacag      720

agacctcaag cctgagaaca tccttctgga tgaggagggc cacatcaaac tcactgactt      780

tggcctgagc aaagaggcca ttgaccacga gaagaaggcc tattctttct gcgggacagt      840

ggagtacatg gcccctgagg tcgtcaaccg ccagggccac tcccatagtg cggactggtg      900

gtcctatggg gtgttgatgt ttgagatgct gacgggctcc ctgcccttcc aggggaagga      960

ccggaaggag accatgacac tgattctgaa ggcgaagcta ggcatgcccc agtttctgag     1020

cactgaagcc cagagcctct tgcgggccct gttcaagcgg aatcctgcca accggctcgg     1080

ctccggccct gatggggcag aggaaatcaa gcggcatgtc ttctactcca ccattgactg     1140

gaataagcta taccgtcgtg agatcaagcc acccttcaag ccagcagtgg ctcagcctga     1200

tgacaccttc tactttgaca ccgagttcac gtcccgcaca cccaaggatt ccccaggcat     1260

cccccccagc gctggggccc atcagctgtt ccggggcttc agcttcgtgg ccaccggcct     1320

gatggaagac gacggcaagc ctcgtgcccc gcaggcaccc ctgcactcgg tggtacagca     1380

actccatggg aagaacctgg tttttagtga cggctacgtg gtaaaggaga caattggtgt     1440

gggctcctac tctgagtgca agcgctgtgt ccacaaggcc accaacatgg agtatgctgt     1500

caaggtcatt gataagagca agcgggatcc ttcagaagag attgagattc ttctgcggta     1560

tggccagcac cccaacatca tcactctgaa agatgtgtat gatgatggca aacacgtgta     1620

cctggtgaca gagctgatgc ggggtgggga gctgctggac aagatcctgc ggcagaagtt     1680

cttctcagag cgggaggcca gctttgtcct gcacaccatt ggcaaaactg tggagtatct     1740

gcactcacag ggggttgtgc acagggacct gaagcccagc aacatcctgt atgtggacga     1800

gtccgggaat cccgagtgcc tgcgcatctg tgactttggt tttgccaaac agctgcgggc     1860

tgagaatggg ctcctcatga caccttgcta cacagccaac tttgtggcgc ctgaggtgct     1920

gaagcgccag ggctacgatg aaggctgcga catctggagc ctgggcattc tgctgtacac     1980

catgctggca ggatatactc catttgccaa cggtcccagt gacacaccag aggaaatcct     2040

aacccggatc ggcagtggga agtttaccct cagtggggga aattggaaca cagtttcaga     2100

gacagccaag gacctggtgt ccaagatgct acacgtggat ccccaccagc gcctcacagc     2160

taagcaggtt ctgcagcatc catgggtcac ccagaaagac aagcttcccc aaagccagct     2220

gtcccaccag gacctacagc ttgtgaaggg agccatggct gccacgtact ccgcactcaa     2280

cagctccaag cccacccccc agctgaagcc catcgagtca tccatcctgg cccagcggcg     2340

agtgaggaag ttgccatcca ccaccctgtg aggcaccagg gcattcgggc cacagggcgg     2400

tgctagcttg acacagtcag catgcttccc agagggagca ggccggaacc acagggccag     2460

agggagctgg aacccgaggg gccggggaag ctgccagccc agaacacccc taatgagggt     2520

gtgagaagtg ccttctcctt ccccaggatg gactcttctc ggctcaggct ctgctggtgg     2580

aaagcgattc actgtataaa ctttttttta tgaaaaaaat ggcatcaacc accatggatt     2640

tttacaagat ccatttgcct ttctgggagc agaaacagcc attgcggccc caggagggga     2700

actgagtcac gctggggctc tctgagactc tttagagcag ctttgggatc ccaccctggg     2760

gacccccacg attggccacc tgtagccatc tgcacacacc tccgagacag tccagtgtca     2820

cctctctcag agcatctggc tgtttagcag aactcattct atccccaatc agctcctttt     2880

ccgttctgtt ctgctgggag ttctagaacc acttcctgct acaggagggg tctcatgtcc     2940

tgctggcttc cagcttcagg caccagcatc caccttggct ctgccagtgg atcccctgcg     3000

gtcaggctgg gcagccccag agagaggatg tggaaagcac tttttggctg acttcatctg     3060

gggttggcaa caggacagag ttcacaggag gccagtgggc gggccatgag ggacagggtc     3120

ttttttcatt tcttcctcag ctggttactc agggttcatc tgtccatggc ctttctaata     3180

aactgttgag ttgaagcac                                                  3199


<210>  52
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys 
            100                 105                 110         


Gly Leu Gly Phe Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys 
        115                 120                 125             


Pro Gln Asn Pro Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
145                 150                 155                 160 


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
                165                 170                 175     


Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
            180                 185                 190         


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
        195                 200                 205             


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu 
    210                 215                 220                 


Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
225                 230                 235                 240 


Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn 
                245                 250                 255     


Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
            260                 265                 270         


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
        275                 280                 285             


Phe Cys Pro Pro 
    290         


<210>  53
<211>  2369
<212>  DNA
<213>  Homo sapiens

<400>  53
cctgggcgcc agcgcagcgt agcaaatcca ggcagcgcca cgcgcggccg gggccgggcg       60

gaaccgagaa gccgggaccg cgctgcgacg cgccggccgc atggagcctg ccgccggttt      120

cctgtctccg cgccccttcc agcgtgcggc cgccgcgccc gctcccccgg ccgggcccgg      180

gccgcctccg agtgccttgc gcggacctga gctggagatg ctggccgggc taccgacgtc      240

agaccccggg cgcctcatca cggacccgcg cagcggccgc acctacctca aaggccgctt      300

gttgggcaag gggggcttcg cccgctgcta cgaggccact gacacagaga ctggcagcgc      360

ctacgctgtc aaagtcatcc cgcagagccg cgtcgccaag ccgcatcagc gcgagaagat      420

cctaaatgag attgagctgc accgagacct gcagcaccgc cacatcgtgc gtttttcgca      480

ccactttgag gacgctgaca acatctacat tttcttggag ctctgcagcc gaaagtccct      540

ggcccacatc tggaaggccc ggcacaccct gttggagcca gaagtgcgct actacctgcg      600

gcagatcctt tctggcctca agtacttgca ccagcgcggc atcttgcacc gggacctcaa      660

gttgggaaat tttttcatca ctgagaacat ggaactgaag gtgggggatt ttgggctggc      720

agcccggttg gagcctccgg agcagaggaa gaagaccatc tgtggcaccc ccaactatgt      780

ggctccagaa gtgctgctga gacagggcca cggccctgag gcggatgtat ggtcactggg      840

ctgtgtcatg tacacgctgc tctgcgggag ccctcccttt gagacggctg acctgaagga      900

gacgtaccgc tgcatcaagc aggttcacta cacgctgcct gccagcctct cactgcctgc      960

ccggcagctc ctggccgcca tccttcgggc ctcaccccga gaccgcccct ctattgacca     1020

gatcctgcgc catgacttct ttaccaaggg ctacaccccc gatcgactcc ctatcagcag     1080

ctgcgtgaca gtcccagacc tgacaccccc caacccagct aggagtctgt ttgccaaagt     1140

taccaagagc ctctttggca gaaagaagaa gagtaagaat catgcccagg agagggatga     1200

ggtctccggt ttggtgagcg gcctcatgcg cacatccgtt ggccatcagg atgccaggcc     1260

agaggctcca gcagcttctg gcccagcccc tgtcagcctg gtagagacag cacctgaaga     1320

cagctcaccc cgtgggacac tggcaagcag tggagatgga tttgaagaag gtctgactgt     1380

ggccacagta gtggagtcag ccctttgtgc tctgagaaat tgtatagcct tcatgccccc     1440

agcggaacag aacccggccc ccctggccca gccagagcct ctggtgtggg tcagcaagtg     1500

ggttgactac tccaataagt tcggctttgg gtatcaactg tccagccgcc gtgtggctgt     1560

gctcttcaac gatggcacac atatggccct gtcggccaac agaaagactg tgcactacaa     1620

tcccaccagc acaaagcact tctccttctc cgtgggtgct gtgccccggg ccctgcagcc     1680

tcagctgggt atcctgcggt acttcgcctc ctacatggag cagcacctca tgaagggtgg     1740

agatctgccc agtgtggaag aggtagaggt acctgctccg cccttgctgc tgcagtgggt     1800

caagacggat caggctctcc tcatgctgtt tagtgatggc actgtccagg tgaacttcta     1860

cggggaccac accaagctga ttctcagtgg ctgggagccc ctccttgtga cttttgtggc     1920

ccgaaatcgt agtgcttgta cttacctcgc ttcccacctt cggcagctgg gctgctctcc     1980

agacctgcgg cagcgactcc gctatgctct gcgcctgctc cgggaccgca gcccagccta     2040

ggacccaagc cctgaggcct gaggcctgtg cctgtcaggc tctggccctt gcctttgtgg     2100

ccttccccct tcctttggtg cctcactggg ggctttgggc cgaatccccc agggaatcag     2160

ggaccagctt tactggagtt gggggcggct tgtcttcgct ggctcctacc ccatctccaa     2220

gataagcctg agccttagct cccagctagg gggcgttatt tatggaccac ttttatttat     2280

tgtcagacac ttatttattg ggatgtgagc cccagggggg cctcctccta ggataataaa     2340

caattttgca gaattggaaa aaaaaaaaa                                       2369


<210>  54
<211>  2681
<212>  DNA
<213>  Homo sapiens

<400>  54
cggggcccag gctgtgcgct tggggagcgc ggaatgtgag gcttggcggg ccgcagcacg       60

ctcggacggg ccaggggcgg cgacccctcg cggacgcccg gctgcgcgcc gggccgggga      120

cttgcccttg cacgctccct gcgccctcca gctcgccggc gggaccatga agaagttctc      180

tcggatgccc aagtcggagg gcggcagcgg cggcggagcg gcgggtggcg gggctggcgg      240

ggccggggcc ggggccggct gcggctccgg cggctcgtcc gtgggggtcc gggtgttcgc      300

ggtcggccgc caccaggtca ccctggaaga gtcgctggcc gaaggtggat tctccacagt      360

tttcctcgtg cgtactcacg gtggaatccg atgtgcattg aagcgaatgt atgtcaataa      420

catgccagac ctcaatgttt gtaaaaggga aattacaatt atgaaagagc tatctggtca      480

caaaaatatt gtgggctatt tggactgtgc tgttaattca attagtgata atgtatggga      540

agtccttatc ttaatggaat attgtcgagc tggacaggta gtgaatcaaa tgaataagaa      600

gctacagacg ggttttacag aaccagaagt gttacagata ttctgtgata cctgtgaagc      660

tgttgcaagg ttgcatcagt gtaagactcc aataattcac cgggatctga aggtagaaaa      720

tattttgttg aatgatggtg ggaactatgt actttgtgac tttggcagtg ccactaataa      780

atttcttaat cctcaaaaag atggagttaa tgtagtagaa gaagaaatta aaaagtatac      840

aactctgtca tacagagccc ctgaaatgat caacctttat ggagggaaac ccatcaccac      900

caaggctgat atctgggcac tgggatgtct actctataaa ctttgtttct tcactcttcc      960

ttttggtgag agtcaggttg ctatctgtga tggcaacttc accatcccag acaattctcg     1020

ttactcccgt aacatacatt gcttaataag gttcatgctt gaaccagatc cggaacatag     1080

acctgatata tttcaagtgt catattttgc atttaaattt gccaaaaagg attgtccagt     1140

ctccaacatc aataattctt ctattccttc agctcttcct gaaccgatga ctgctagtga     1200

agcagctgct aggaaaagcc aaataaaagc cagaataaca gataccattg gaccaacaga     1260

aacctcaatt gcaccaagac aaagaccaaa ggccaactct gctactactg ccactcccag     1320

tgtgctgacc attcaaagtt cagcaacacc tgttaaagtc cttgctcctg gtgaattcgg     1380

taaccataga ccaaaagggg cactaagacc tggaaatggc cctgaaattt tattgggtca     1440

gggacctcct cagcagccgc cacagcagca tagagtactc cagcaactac agcagggaga     1500

ttggagatta cagcaactcc atttacagca tcgtcatcct caccagcagc agcagcagca     1560

gcagcagcaa cagcaacagc agcagcagca acagcaacag cagcagcagc agcagcagca     1620

gcagcaccac caccaccacc accaccacct acttcaagat gcttatatgc agcagtatca     1680

acatgcaaca cagcagcaac agatgcttca acaacaattt ttaatgcatt cggtatatca     1740

accacaacct tctgcatcac agtatcctac aatgatgccg cagtatcagc aggctttctt     1800

tcaacagcag atgctagctc aacatcagcc gtctcaacaa caggcatcac ctgaatatct     1860

tacctcccct caagagttct caccagcctt agtttcctac acttcatcac ttccagctca     1920

ggttggaacc ataatggact cctcctatag tgccaatagg tcagttgctg ataaagaggc     1980

cattgcaaat ttcacaaatc agaagaacat cagcaatcca cctgatatgt cagggtggaa     2040

tccttttgga gaggataatt tctctaagtt aacagaagag gaactattgg acagagaatt     2100

tgaccttcta agatcaagta agggacactt gaaggcttat tttgcttcac agtaaaataa     2160

cagctctatt attattcagc aaggccaaag acttttgaga atgtgtatgg aaaattcttt     2220

ttgtgcattt gagggcaaaa ttcaggccat cttcttatac atatactatc aaattatgtt     2280

gtgtgcatta gaaatcagtt gcttgatagt agctattaaa cccaatattg ctgatagtat     2340

gctaatatcc taaaacttaa atattgcata tctatgaatg ttaaattcag aatatctcta     2400

aaacatggaa aattgatgtt tcaataaaaa gggagacatt ttattatttt gccttactaa     2460

tgattttgca gctctgtttt tctgcacact caatagaaaa tattgtgggt ctgagatgcc     2520

ctttgaaaat gcctgaaaga aaacatgggc tactacatta tgttaatgtt ttgtaatgtc     2580

cttttaatga gtggtgacat aaaagggctg ctttgttgtc ctgatatggc aaaaattaaa     2640

taaattcttt ttcactttaa atcagaaaaa aaaaaaaaaa a                         2681


<210>  55
<211>  3830
<212>  DNA
<213>  Homo sapiens

<400>  55
gtcaccacca gcctagctcg gacggcaagc ggcgggagat tttcaaaatg ggagcccaga       60

ggcaccgccc aggcctcgga aggtgtcagg gagaactttc cgtggtttca gcgtcgtcgc      120

ctggagcggc ggtttagaga gccgagcctg atgggcgcca aggccggctg gctgcttgga      180

gcgctgcctc gaagggactg cgtgaaggaa gctaatccgg agaacccagg ccagagcctg      240

gaaatatggc gacctgcatc ggggagaaga tcgaggattt taaagttgga aatctgcttg      300

gtaaaggatc atttgctggt gtctacagag ctgagtccat tcacactggt ttggaagttg      360

caatcaaaat gatagataag aaagccatgt acaaagcagg aatggtacag agagtccaaa      420

atgaggtgaa aatacattgc caattgaaac atccttctat cttggagctt tataactatt      480

ttgaagatag caattatgtg tatctggtat tagaaatgtg ccataatgga gaaatgaaca      540

ggtatctaaa gaatagagtg aaacccttct cagaaaatga agctcgacac ttcatgcacc      600

agatcatcac agggatgttg tatcttcatt ctcatggtat actacaccgg gacctcacac      660

tttctaacct cctactgact cgtaatatga acatcaagat tgctgatttt gggctggcaa      720

ctcaactgaa aatgccacat gaaaagcact atacattatg tggaactcct aactacattt      780

caccagaaat tgccactcga agtgcacatg gccttgaatc tgatgtttgg tccctgggct      840

gtatgtttta tacattactt atcgggagac cacccttcga cactgacaca gtcaagaaca      900

cattaaataa agtagtattg gcagattatg aaatgccatc ttttttgtca atagaggcca      960

aggaccttat tcaccagtta cttcgtagaa atccagcaga tcgtttaagt ctgtcttcag     1020

tattggacca tccttttatg tcccgaaatt cttcaacaaa aagtaaagat ttaggaactg     1080

tggaagactc aattgatagt gggcatgcca caatttctac tgcaattaca gcttcttcca     1140

gtaccagtat aagtggtagt ttatttgaca aaagaagact tttgattggt cagccactcc     1200

caaataaaat gactgtattt ccaaagaata aaagttcaac tgatttttct tcttcaggag     1260

atggaaacag tttttatact cagtggggaa atcaagaaac cagtaatagt ggaaggggaa     1320

gagtaattca agatgcagaa gaaaggccac attctcgata ccttcgtaga gcttattcct     1380

ctgatagatc tggcacttct aatagtcagt ctcaagcaaa aacatataca atggaacgat     1440

gtcactcagc agaaatgctt tcagtgtcca aaagatcagg aggaggtgaa aatgaagaga     1500

ggtactcacc cacagacaac aatgccaaca tttttaactt ctttaaagaa aagacatcca     1560

gtagttctgg atcttttgaa agacctgata acaatcaagc actctccaat catctttgtc     1620

caggaaaaac tccttttcca tttgcagacc cgacacctca gactgaaacc gtacaacagt     1680

ggtttgggaa tctgcaaata aatgctcatt taagaaaaac tactgaatat gacagcatca     1740

gcccaaaccg ggacttccag ggccatccag atttgcagaa ggacacatca aaaaatgcct     1800

ggactgatac aaaagtcaaa aagaactctg atgcttctga taatgcacat tctgtaaaac     1860

agcaaaatac catgaaatat atgactgcac ttcacagtaa acctgagata atccaacaag     1920

aatgtgtttt tggctcagat cctctttctg aacagagcaa gactaggggt atggagccac     1980

catggggtta tcagaatcgt acattaagaa gcattacatc tccgttggtt gctcacaggt     2040

taaaaccaat cagacagaaa accaaaaagg ctgtggtgag catacttgat tcagaggagg     2100

tgtgtgtgga gcttgtaaag gagtatgcat ctcaagaata tgtgaaagaa gttcttcaga     2160

tatctagtga tggaaatacg atcactattt attatccaaa tggtggtaga ggttttcctc     2220

ttgctgatag accaccctca cctactgaca acatcagtag gtacagcttt gacaatttac     2280

cagaaaaata ctggcgaaaa tatcaatatg cttccaggtt tgtacagctt gtaagatcta     2340

aatctcccaa aatcacttat tttacaagat atgctaaatg cattttgatg gagaattctc     2400

ctggtgctga ttttgaggtt tggttttatg atggggtaaa aatacacaaa acagaagatt     2460

tcattcaggt gattgaaaag acagggaagt cttacacttt aaaaagtgaa agtgaagtta     2520

atagcttgaa agaggagata aaaatgtata tggaccatgc taatgagggt catcgtattt     2580

gtttagcact ggaatccata atttcagaag aggaaaggaa aactaggagt gctccctttt     2640

tcccaataat cataggaaga aaacctggta gtactagttc acctaaggcc ttatcacctc     2700

ctccttctgt ggattcaaat tacccaacga gagagagagc atctttcaac agaatggtca     2760

tgcatagtgc tgcttctcca acacaggcac caatccttaa tccctctatg gttacaaatg     2820

aaggacttgg tcttacaact acagcttctg gaacagacat ctcttctaat agtctaaaag     2880

attgtcttcc taaatcagca caacttttga aatctgtttt tgtgaaaaat gttggttggg     2940

ctacacagtt aactagtgga gctgtgtggg ttcagtttaa tgatgggtcc cagttggttg     3000

tgcaggcagg agtgtcttct atcagttata cctcaccaaa tggtcaaaca actaggtatg     3060

gagaaaatga aaaattacca gactacatca aacagaaatt acagtgtctg tcttccatcc     3120

ttttgatgtt ttctaatccg actcctaatt ttcattgatt aaaactcctt tcagacatat     3180

aagtttaata aataactttt ttgttgactt tcaagtaaag tgattttttt taatttaaca     3240

taaagtcttc agaaagcctt tctatgaaag aattttaacc tataatgtaa aggatgtatt     3300

ctgagagaac aaagcagaat gaaacttgag tcacttacta aatatagtgg atataaaata     3360

gaacacctga ctttgctctt agaccataac ccccgaactt actatgttca tatatttgta     3420

ttgaacaatc ttttaaaagc aaaaatgtaa atgatgtgta gtttatttgt gcttttattg     3480

ttttccctgc gtctcagaca tgttgagaat catggacaaa acctgctgga attttggaat     3540

ttttgaagat gtaaataatg tgtatttatg ttataagtaa catatgtaaa catgtatatt     3600

tgttttatat ttatttttgt aacaccagtg tctgatgaaa catttttgca aatgcatttt     3660

ataaaaaaat aaatatagtg ataagttaca ttatcttttg attcatttaa ttaaatactt     3720

atttttaaat aacttaccag taaactcact ttttaaattt tgttgcctgt tgaggagcca     3780

attaaatttt aaatattaat tttgcaaatg ttaaaaaaaa aaaaaaaaaa                3830


<210>  56
<211>  4836
<212>  DNA
<213>  Homo sapiens

<400>  56
agaagccccg ggctcgtcag tcaaaccggt tctctgtttg cactcggcag cacgggcagg       60

caagtggtcc ctaggttcgg gagcagagca gcagcgcctc agtcctggtc ccccagtccc      120

aagcctcacc tgcctgccca gcgccaggat ggccaccatc acctgcaccc gcttcacgga      180

agagtaccag ctcttcgagg aattgggcaa gggagccttc tcggtggtgc gaaggtgtgt      240

gaaggtgctg gctggccagg agtatgctgc caagatcatc aacacaaaga agctgtcagc      300

cagagaccat cagaagctgg agcgtgaagc ccgcatctgc cgcctgctga agcaccccaa      360

catcgtccga ctacatgaca gcatctcaga ggagggacac cactacctga tcttcgacct      420

ggtcactggt ggggaactgt ttgaagatat cgtggcccgg gagtattaca gtgaggcgga      480

tgccagtcac tgtatccagc agatcctgga ggctgtgctg cactgccacc agatgggggt      540

ggtgcaccgg gacctgaagc ctgagaatct gttgctggcc tccaagctca agggtgccgc      600

agtgaagctg gcagactttg gcctggccat agaggtggag ggggagcagc aggcatggtt      660

tgggtttgca gggactcctg gatatctctc cccagaagtg ctgcggaagg acccgtacgg      720

gaagcctgtg gacctgtggg cttgtggggt catcctgtac atcctgctgg ttgggtaccc      780

cccgttctgg gatgaggacc agcaccgcct gtaccagcag atcaaagccg gcgcctatga      840

tttcccatcg ccggaatggg acactgtcac cccggaagcc aaggatctga tcaataagat      900

gctgaccatt aacccatcca aacgcatcac agctgccgaa gcccttaagc acccctggat      960

ctcgcaccgc tccaccgtgg catcctgcat gcacagacag gagaccgtgg actgcctgaa     1020

gaagttcaat gccaggagga aactgaaggg agccattctc accacgatgc tggccaccag     1080

gaacttctcc ggagggaaga gtgggggaaa caagaagagc gatggtgtga agaaaagaaa     1140

gtccagttcc agcgttcagt taatggaatc ctcagagagc accaacacca ccatcgagga     1200

tgaagacacc aaagtgcgga aacaggaaat tataaaagtg acagagcagc tgattgaagc     1260

cataagcaat ggagattttg agtcctacac gaagatgtgc gaccctggca tgacagcctt     1320

cgaacctgag gccctgggga acctggttga gggcctggac ttccatcgat tctattttga     1380

aaacctgtgg tcccggaaca gcaagcccgt gcacaccacc atcctgaatc cccacatcca     1440

cctgatgggc gacgagtcag cctgcatcgc ctacatccgc atcacgcagt acctggacgc     1500

tggcggcatc ccacgcaccg cccagtcgga ggagacccgt gtctggcacc gccgggatgg     1560

caaatggcag atcgtccact tccacagatc tggggcgccc tccgtcctgc cccactgagg     1620

gaccaggctg gggtcgctgc gttgctgtgc cgcagagatc cactctgtcc gtggagtgga     1680

gctgctggtt ctcccaggtg gattttgctg gaattctccc atgtcatcac cccaccaccg     1740

tcacttctgt acctgcatca agaaaacctg cttgttcaca aaagtcatcg caacttcaga     1800

gcgaacggcc acatctcccc acctctcacc cccaccctct cccctgccag gctggggctt     1860

cctcaggcat gggtgtccac agcactggcc ccctctcccc agcctcagct gctgtccgcc     1920

tgatctgtct tgggctgtag gctagaatgc ccgggctggt gcccaccagg ggctggggag     1980

aaggaggggt ggcatgatga ggaaggcagc atccgtccgt ccctctccca gacctctcct     2040

cttccagtgt ccccggggaa gggcagatga cactcccttc cccctaagcc aaccgcactg     2100

aaggagtggg gagaagagca tacgccagga gcctcctgcc tcaaagtgct cccctaagtc     2160

ttcttcctcc tgtgctgacc tcagggtggt ctgacccttc cctcggtgtg ggggatgtgg     2220

ccctctcagg tgcccctact tgctttctgc ttccttctgg tgaagtccac ctccaacatt     2280

aacctgccca ccccaccccc gtcatccctg gagaattcca gctttgtcgt atctcagaga     2340

gggaatctaa ttgtttttgg ggggcaaaag aaagcaacgt ttaggtatca cttctacttg     2400

gaccgcatgc ctttttatag ccaaatttct gtgtatttcg taaatggatt tcgcgttaat     2460

ggatatttat gtaataacta gacttctcag attattgtga gaagggtcag gttggaaggg     2520

gtgtaggaag aggggtgagg ggtagttttt ttctgttcta gttttttttt ttttttttgt     2580

catctctgag gtggaccttg tcacctgtgg ttattggggc caaggtggac tcagctccgg     2640

ggagaagggc ctctctgcca tttcggtccc aaggtgagct gacacaggcg ttccttttgg     2700

gactgtggaa gcatcagatg ccagcactga ctcaggaaca gcaagtcagg gcagagagga     2760

ggagggaggc tgtcaggatg gaaatacctg gacttttctt tgcttccctc gcaaactggg     2820

gtcttctcta ccgaacttcc caggatttca tctcaccata tctgtgtgcc gcccccagca     2880

ccccccaccc acctctgggg ggcccgtgag cgtgtgtctt cattgcctct ctccccttgg     2940

cgtctgatga ccacagcaaa gcactgggaa tttctactct tcatgcctca tcctgcagcc     3000

tcgggttcgc attctctctt tcttttcctc tttccctctt tccctgggat tgactctgag     3060

tggaatacct tggcacatcc actaggatct actgtctgca ctgttttctt tgcatgactt     3120

tatacgcagt aagtatgttg aaaacaaaca aaaagaagaa aacactcaac aaaaccaatc     3180

tacatgtttt ggactaaaaa aaaaaataga ggttgtattc tcagtgtccg actcggaatt     3240

atgttgctgc ctctctgtgc ttttggcctc tgtgtggccg tgttttgcca gcatgagata     3300

ctgtcccctc tggaggattt taggggagga agagccacgt ccccagggat tggaggaggc     3360

tccggtaccc tcgaccctcc tgggtgttgg ttggagcaga actggtgagg atgtttgatc     3420

cgagattttc tgagctctcc ccaatcacca gctgtctgct gggttctttt ctcaagtcct     3480

gctgcccagg cccaggtgag acaggcaacg ccaggtctgc aggccaggag agatgctgcc     3540

caggcctcct ggtttccaag ctggtccatc actggcctct gtccttggca gagaccttgc     3600

tgcccaggcc caggggcagg ctcttggcct gccccaggcc cagagggctt cccagtaagg     3660

cccagtgatc ccattatccc aggggcaaaa ccacctgtcc ccttttgagc tgccagttcc     3720

ctacagccat ccccagtcaa gggtgagggt gtggccttca ccaggggctg ctgtaattac     3780

cgagcaaggt ctgagctctt cttcagcctc agttccctca ttggttaaaa gggttctttg     3840

ttcccatcca gccgatgaag gagcaaacgt ctggctatgt gaagcctaat ttacctgcag     3900

gaactggcag ggatagtcac tggctggact cctgtttact tctagacctg gtcaggctcc     3960

atcccctccc ccacctgccc ctgattcccc tcgtcggtgc ctgtcaactg cttttcagca     4020

gtggactgca ggggaaagag cagtgatttg gggtgagtag gcttcaattc ccagctctga     4080

ccagacttgc tgtgtgacct tgggcaagtt cctttccctc tttggagctt ggtttccctg     4140

ccagaggaaa ctgagctgga ggagcctgag gtcctgcctt tcattggctg acacacctcc     4200

tgtccactgt gtcactctcc aagtgccaga gaagtggagg cagatcgcta ccccaggctg     4260

agatggcccc cactgtgaag gccacgcctg tgggtgggca gccacctggt gccaccacag     4320

ggcaccaggg atgatcctga tgtggcaggc aggggagact cacagaaaaa tctgcccaga     4380

gcctaccctc accagacaaa ctctgtgctc ctccaaaaca tcctttagat gcaaaataat     4440

aataataata ataataaata aataaataaa aatccaaacc caagtcaaaa ccttggctcc     4500

agcatgaaaa cacgtttaca ggaaagtgtt ctcctgggtt tgtgcccacc atggtgcgaa     4560

tcctgaccca aggcctcctg tctcccttca aagggagacc cttttggggg atgagtttgc     4620

cagactcccc gtgctggttt ctttgttact atttgtttgg ggttttgttt tagttctttt     4680

tttttttctt ttctttttta aaaatatgtg gctgtgaact tgaatgaaca ctgctcaaac     4740

tttctgctat tggggggggc gggtgggatg ggaagaaggg gcgtttgttt tattcttggt     4800

gttttcagtg caataaatag ctacaaactt ctgtgc                               4836


<210>  57
<211>  302
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (93)..(94)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (171)..(171)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (187)..(187)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (218)..(218)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (228)..(228)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (237)..(237)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (257)..(258)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (267)..(267)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  n is a, c, g, t or u

<400>  57
makskkksds tkvdvkggsy gsvkahksgv vakvvsdksm cdsyvvkyyg sykntdwvmy       60

cgagsvsdrr nktdatkstk gyhmrkhrdk agnntghaka dgvagtdtma krntvgtwma      120

vgyncvadws gtsmagkyad hmramtntrk wsddtdvkkc vknratathk nakvsrdtam      180

kakrhrnsdd dshtmvktsv svgtmratst msgatmhnst msdgtmvnsd dgtmkrnats      240

vrsmdydkdk nkshncnnmh msknvdnwkv dgddknsmrk admmrrryta krdamdakkr      300

rn                                                                     302


<210>  58
<211>  2323
<212>  DNA
<213>  Homo sapiens

<400>  58
cccgcctcct ggtaggaggg ggtttccgct tccggcagca gcggctgcag cctcgctctg       60

gtccctgcgg ctggcggccg agccgtgtgt ctcctcctcc atcgccgcca tattgtctgt      120

gtgagcagag gggagagcgg ccgccgccgc tgccgcttcc accacagttt gaagaaaaca      180

ggtctgaaac aaggtcttac ccccagctgc ttctgaacac agtgactgcc agatctccaa      240

acatcaagtc cagctttgtc cgccaacctg tctgacatgt cgggacccgt gccaagcagg      300

gccagagttt acacagatgt taatacacac agacctcgag aatactggga ttacgagtca      360

catgtggtgg aatggggaaa tcaagatgac taccagctgg ttcgaaaatt aggccgaggt      420

aaatacagtg aagtatttga agccatcaac atcacaaata atgaaaaagt tgttgttaaa      480

attctcaagc cagtaaaaaa gaagaaaatt aagcgtgaaa taaagatttt ggagaatttg      540

agaggaggtc ccaacatcat cacactggca gacattgtaa aagaccctgt gtcacgaacc      600

cccgccttgg tttttgaaca cgtaaacaac acagacttca agcaattgta ccagacgtta      660

acagactatg atattcgatt ttacatgtat gagattctga aggccctgga ttattgtcac      720

agcatgggaa ttatgcacag agatgtcaag ccccataatg tcatgattga tcatgagcac      780

agaaagctac gactaataga ctggggtttg gctgagtttt atcatcctgg ccaagaatat      840

aatgtccgag ttgcttcccg atacttcaaa ggtcctgagc tacttgtaga ctatcagatg      900

tacgattata gtttggatat gtggagtttg ggttgtatgc tggcaagtat gatctttcgg      960

aaggagccat ttttccatgg acatgacaat tatgatcagt tggtgaggat agccaaggtt     1020

ctggggacag aagatttata tgactatatt gacaaataca acattgaatt agatccacgt     1080

ttcaatgata tcttgggcag acactctcga aagcgatggg aacgctttgt ccacagtgaa     1140

aatcagcacc ttgtcagccc tgaggccttg gatttcctgg acaaactgct gcgatatgac     1200

caccagtcac ggcttactgc aagagaggca atggagcacc cctatttcta cactgttgtg     1260

aaggaccagg ctcgaatggg ttcatctagc atgccagggg gcagtacgcc cgtcagcagc     1320

gccaatatga tgtcagggat ttcttcagtg ccaacccctt caccccttgg acctctggca     1380

ggctcaccag tgattgctgc tgccaacccc cttgggatgc ctgttccagc tgccgctggc     1440

gctcagcagt aacggcccta tctgtctcct gatgcctgag cagaggtggg ggagtccacc     1500

ctctccttga tgcagcttgc gcctggcggg gaggggtgaa acacttcaga agcaccgtgt     1560

ctgaaccgtt gcttgtggat ttatagtagt tcagtcataa aaaaaaaatt ataataggct     1620

gattttcttt tttctttttt tttttaactc gaacttttca taactcaggg gattccctga     1680

aaaattacct gcaggtggaa tatttcatgg acaaattttt ttttctcccc tcccaaattt     1740

agttcctcat cacaaaagaa caaagataaa ccagcctcaa tcccggctgc tgcatttagg     1800

tggagacttc ttcccattcc caccattgtt cctccaccgt cccacacttt agggggttgg     1860

tatctcgtgc tcttctccag agattacaaa aatgtagctt ctcaggggag gcaggaagaa     1920

aggaaggaag gaaagaagga agggaggacc caatctatag gagcagtgga ctgcttgctg     1980

gtcgcttaca tcactttact ccataagcgc ttcagtgggg ttatcctagt ggctcttgtg     2040

gaagtgtgtc ttagttacat caagatgttg aaaatctacc caaaatgcag acagatacta     2100

aaaacttctg ttcagtaaga atcatgtctt actgatctaa ccctaaatcc aactcattta     2160

tacttttatt tttagttcag tttaaaatgt tgataccttc cctcccaggc tccttacctt     2220

ggtcttttcc ctgttcatct cccaacatgc tgtgctccat agctggtagg agagggaagg     2280

caaaatcttt cttagttttc tttgtcttgg ccattttgaa ttc                       2323


<210>  59
<211>  1707
<212>  DNA
<213>  Homo sapiens

<400>  59
ctctccgctg ctgtcgccag gagtcacttc acgagaagcc aggtcacaac cgtcggccct       60

tgtctggaaa agtaaaagtg gatcctgcca cgttcggagc tccctggcgc ctcgcccggc      120

tggagctaga gaactcgtcc tgtggcggcc cccggcgtgg ggcgggacag cggccccctg      180

gagggggcag tcccgggaga acctgcggcg gccggagcgg taaaaataag tgactaaaga      240

agcagacctg ggaatcacct aacatgtcga ggaggagatt tgattgccga agtatttcag      300

gcctactaac tacaactcct caaattccaa taaaaatgga aaactttaat aatttctata      360

tacttacatc taaagagcta gggagaggta aatttgctgt ggttagacaa tgtatatcaa      420

aatctactgg ccaagaatat gctgcaaaat ttctaaaaaa gagaagaaga ggacaggatt      480

gtcgggcaga aattttacac gagattgctg tgcttgaatt ggcaaagtct tgtccccgtg      540

ttattaatct tcatgaggtc tatgaaaata caagtgaaat cattttgata ttggaatatg      600

ctgcaggtgg agaaattttc agcctgtgtt tacctgagtt ggctgaaatg gtttctgaaa      660

atgatgttat cagactcatt aaacaaatac ttgaaggagt ttattatcta catcagaata      720

acattgtaca ccttgattta aagccacaga atatattact gagcagcata taccctctcg      780

gggacattaa aatagtagat tttggaatgt ctcgaaaaat agggcatgcg tgtgaacttc      840

gggaaatcat gggaacacca gaatatttag ctccagaaat cctgaactat gatcccatta      900

ccacagcaac agatatgtgg aatattggta taatagcata tatgttgtta actcacacat      960

caccatttgt gggagaagat aatcaagaaa catacctcaa tatctctcaa gttaatgtag     1020

attattcgga agaaactttt tcatcagttt cacagctggc cacagacttt attcagagcc     1080

ttttagtaaa aaatccagag aaaagaccaa cagcagagat atgcctttct cattcttggc     1140

tacagcagtg ggactttgaa aacttgtttc accctgaaga aacttccagt tcctctcaaa     1200

ctcaggatca ttctgtaagg tcctctgaag acaagacttc taaatcctcc tgtaatggaa     1260

cctgtggtga tagagaagac aaagagaata tcccagagga tagcagcatg gtttccaaaa     1320

gatttcgttt cgatgactca ttacccaatc cccatgaact tgtttcagat ttgctctgtt     1380

agcacttttt tctttgactc atttggactg aatttgaaat tttatatcca ctccagtgag     1440

attatgattt gtagcttcat atatgacatg tttatattgt aaatgcactt ttccatggaa     1500

taatttaggg aagtgtttta atgttaaatt actagttgct agcatgttat gatttcatat     1560

cctgagatag ctctgcagat aagaaaatat ttaaatatat gacaaaaagt aaaattgtac     1620

atgtgagttt acatgttaat gaaataattc aacttcaaat gaacttacca gaatgttttg     1680

catatcaaca aaaaaaaaaa aaaaaaa                                         1707


<210>  60
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asp Tyr Asp Phe Lys Val Lys Leu Ser Ser Glu Arg Glu Arg Val 
1               5                   10                  15      


Glu Asp Leu Phe Glu Tyr Glu Gly Cys Lys Val Gly Arg Gly Thr Tyr 
            20                  25                  30          


Gly His Val Tyr Lys Ala Lys Arg Lys Asp Gly Lys Asp Asp Lys Asp 
        35                  40                  45              


Tyr Ala Leu Lys Gln Ile Glu Gly Thr Gly Ile Ser Met Ser Ala Cys 
    50                  55                  60                  


Arg Glu Ile Ala Leu Leu Arg Glu Leu Lys His Pro Asn Val Ile Ser 
65                  70                  75                  80  


Leu Gln Lys Val Phe Leu Ser His Ala Asp Arg Lys Val Trp Leu Leu 
                85                  90                  95      


Phe Asp Tyr Ala Glu His Asp Leu Trp His Ile Ile Lys Phe His Arg 
            100                 105                 110         


Ala Ser Lys Ala Asn Lys Lys Pro Val Gln Leu Pro Arg Gly Met Val 
        115                 120                 125             


Lys Ser Leu Leu Tyr Gln Ile Leu Asp Gly Ile His Tyr Leu His Ala 
    130                 135                 140                 


Asn Trp Val Leu His Arg Asp Leu Lys Pro Ala Asn Ile Leu Val Met 
145                 150                 155                 160 


Gly Glu Gly Pro Glu Arg Gly Arg Val Lys Ile Ala Asp Met Gly Phe 
                165                 170                 175     


Ala Arg Leu Phe Asn Ser Pro Leu Lys Pro Leu Ala Asp Leu Asp Pro 
            180                 185                 190         


Val Val Val Thr Phe Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Ala 
        195                 200                 205             


Arg His Tyr Thr Lys Ala Ile Asp Ile Trp Ala Ile Gly Cys Ile Phe 
    210                 215                 220                 


Ala Glu Leu Leu Thr Ser Glu Pro Ile Phe His Cys Arg Gln Glu Asp 
225                 230                 235                 240 


Ile Lys Thr Ser Asn Pro Tyr His His Asp Gln Leu Asp Arg Ile Phe 
                245                 250                 255     


Asn Val Met Gly Phe Pro Ala Asp Lys Asp Trp Glu Asp Ile Lys Lys 
            260                 265                 270         


Met Pro Glu His Ser Thr Leu Met Lys Asp Phe Arg Arg Asn Thr Tyr 
        275                 280                 285             


Thr Asn Cys Ser Leu Ile Lys Tyr Met Glu Lys His Lys Val Lys Pro 
    290                 295                 300                 


Asp Ser Lys Ala Phe His Leu Leu Gln Lys Leu Leu Thr Met Asp Pro 
305                 310                 315                 320 


Ile Lys Arg Ile Thr Ser Glu Gln Ala Met Gln Asp Pro Tyr Phe Leu 
                325                 330                 335     


Glu Asp Pro Leu Pro Thr Ser Asp Val Phe Ala Gly Cys Gln Ile Pro 
            340                 345                 350         


Tyr Pro Lys Arg Glu Phe Leu Thr Glu Glu Glu Pro Asp Asp Lys Gly 
        355                 360                 365             


Asp Lys Lys Asn Gln Gln Gln Gln Gln Gly Asn Asn His Thr Asn Gly 
    370                 375                 380                 


Thr Gly His Pro Gly Asn Gln Asp Ser Ser His Thr Gln Gly Pro Pro 
385                 390                 395                 400 


Leu Lys Lys Val Arg Val Val Pro Pro Thr Thr Thr Ser Gly Gly Leu 
                405                 410                 415     


Ile Met Thr Ser Asp Tyr Gln Arg Ser Asn Pro His Ala Ala Tyr Pro 
            420                 425                 430         


Asn Pro Gly Pro Ser Thr Ser Gln Pro Gln Ser Ser Met Gly Tyr Ser 
        435                 440                 445             


Ala Thr Ser Gln Gln Pro Pro Gln Tyr Ser His Gln Thr His Arg Tyr 
    450                 455                 460                 


<210>  61
<211>  1879
<212>  DNA
<213>  Homo sapiens

<400>  61
agttccaagt ttggagcttt tagctgccag ccctggccca tcatgtagct gcagcacagc       60

cttccctaac gttgcaactg ggggaaaaat cactttccag tctgttttgc aaggtgtgca      120

tttccatctt gattccctga aagtccatct gctgcatcgg tcaagagaaa ctccacttgc      180

atgaagattg cacgcctgca gcttgcatct ttgttgcaaa actagctaca gaagagaagc      240

aaggcaaagt cttttgtgct cccctccccc atcaaaggaa aggggaaaat gtctcagtcg      300

aaaggcaaga agcgaaaccc tggccttaaa attccaaaag aagcatttga acaacctcag      360

accagttcca caccacctcg agatttagac tccaaggctt gcatttctat tggaaatcag      420

aactttgagg tgaaggcaga tgacctggag cctataatgg aactgggacg aggtgcgtac      480

ggggtggtgg agaagatgcg gcacgtgccc agcgggcaga tcatggcagt gaagcggatc      540

cgagccacag taaatagcca ggaacagaaa cggctactga tggatttgga tatttccatg      600

aggacggtgg actgtccatt cactgtcacc ttttatggcg cactgtttcg ggagggtgat      660

gtgtggatct gcatggagct catggataca tcactagata aattctacaa acaagttatt      720

gataaaggcc agacaattcc agaggacatc ttagggaaaa tagcagtttc tattgtaaaa      780

gcattagaac atttacatag taagctgtct gtcattcaca gagacgtcaa gccttctaat      840

gtactcatca atgctctcgg tcaagtgaag atgtgcgatt ttggaatcag tggctacttg      900

gtggactctg ttgctaaaac aattgatgca ggttgcaaac catacatggc ccctgaaaga      960

ataaacccag agctcaacca gaagggatac agtgtgaagt ctgacatttg gagtctgggc     1020

atcacgatga ttgagttggc catccttcga tttccctatg attcatgggg aactccattt     1080

cagcagctca aacaggtggt agaggagcca tcgccacaac tcccagcaga caagttctct     1140

gcagagtttg ttgactttac ctcacagtgc ttaaagaaga attccaaaga acggcctaca     1200

tacccagagc taatgcaaca tccatttttc accctacatg aatccaaagg aacagatgtg     1260

gcatcttttg taaaactgat tcttggagac taaaaagcag tggacttaat cggttgaccc     1320

tactgtggat tggtgggttt cggggtgaag caagttcact acagcatcaa tagaaagtca     1380

tctttgagat aatttaaccc tgcctctcag agggttttct ctcccaattt tctttttact     1440

ccccctctta agggggcctt ggaatctata gtatagaatg aactgtctag atggatgaat     1500

tatgataaag gcttaggact tcaaaaggtg attaaatatt taatgatgtg tcatatgagt     1560

cctcaagctt ctcagacttc tcttattctt tacaaaatga atgcattggc cctgacaaaa     1620

aggtgctacg gtagtgatga aattataagt agatttgtag tttgtcccat ttattatttt     1680

aatatttatg tttaagtgct tggttgaaaa gattccattt tatacaagaa gggagattca     1740

aaaaaaaaat ataaggttgg gttagcaata tttatagggc ttttattttt taagttcaat     1800

tgtgtctgtg gtccagaaga aattatttaa tatgcatctt tgagaatatt ataaaaatat     1860

caaaaaggaa aaaaaaaaa                                                  1879


<210>  62
<211>  2684
<212>  DNA
<213>  Homo sapiens

<400>  62
cccgagagga gtcggtggca gcggcggcgg cgggaccggc agcagcagca gcagcagcag       60

cagcaaccac tagcctcctg ccccgcggcg ctgccgcacg agccccacga gccgctcacc      120

ccgccgttct cagcgctgcc cgaccccgct ggcgcgccct cccgccgcca gtcccggcag      180

cgccctcagt tgtcctccga ctcgccctcg gccttccgcg ccagccgcag ccacagccgc      240

aacgccaccc gcagccacag ccacagccac agccccaggc atagccttcg gcacagcccc      300

ggctccggct cctgcggcag ctcctctggg caccgtccct gcgccgacat cctggaggtt      360

gggatgctct tgtccaaaat caactcgctt gcccacctgc gcgccgcgcc ctgcaacgac      420

ctgcacgcca ccaagctggc gcccggcaag gagaaggagc ccctggagtc gcagtaccag      480

gtgggcccgc tactgggcag cggcggcttc ggctcggtct actcaggcat ccgcgtctcc      540

gacaacttgc cggtggccat caaacacgtg gagaaggacc ggatttccga ctggggagag      600

ctgcctaatg gcactcgagt gcccatggaa gtggtcctgc tgaagaaggt gagctcgggt      660

ttctccggcg tcattaggct cctggactgg ttcgagaggc ccgacagttt cgtcctgatc      720

ctggagaggc ccgagccggt gcaagatctc ttcgacttca tcacggaaag gggagccctg      780

caagaggagc tggcccgcag cttcttctgg caggtgctgg aggccgtgcg gcactgccac      840

aactgcgggg tgctccaccg cgacatcaag gacgaaaaca tccttatcga cctcaatcgc      900

ggcgagctca agctcatcga cttcgggtcg ggggcgctgc tcaaggacac cgtctacacg      960

gacttcgatg ggacccgagt gtatagccct ccagagtgga tccgctacca tcgctaccat     1020

ggcaggtcgg cggcagtctg gtccctgggg atcctgctgt atgatatggt gtgtggagat     1080

attcctttcg agcatgacga agagatcatc aggggccagg ttttcttcag gcagagggtc     1140

tcttcagaat gtcagcatct cattagatgg tgcttggccc tgagaccatc agataggcca     1200

accttcgaag aaatccagaa ccatccatgg atgcaagatg ttctcctgcc ccaggaaact     1260

gctgagatcc acctccacag cctgtcgccg gggcccagca aatagcagcc tttctggcag     1320

gtcctcccct ctcttgtcag atgcccgagg gaggggaagc ttctgtctcc agcttcccga     1380

gtaccagtga cacgtctcgc caagcaggac agtgcttgat acaggaacaa catttacaac     1440

tcattccaga tcccaggccc ctggaggctg cctcccaaca gtggggaaga gtgactctcc     1500

aggggtccta ggcctcaact cctcccatag atactctctt cttctcatag gtgtccagca     1560

ttgctggact ctgaaatatc ccgggggtgg ggggtggggg tgggtcagaa ccctgccatg     1620

gaactgtttt cttcatcatg agttctgctg aatgccgcga tgggtcaggt aggggggaaa     1680

caggttggga tgggatagga ctagcaccat tttaagtccc tgtcacctct tccgactctt     1740

tctgagtgcc ttctgtgggg actccggctg tgctgggaga aatacttgaa cttgcctctt     1800

ttacctgctg cttctccaaa aatctgcctg ggttttgttc cctatttttc tctcctgtcc     1860

tccctcaccc cctccttcat atgaaaggtg ccatggaaga ggctacaggg ccaaacgctg     1920

agccacctgc ccttttttct gcctccttta gtaaaactcc gagtgaactg gtcttccttt     1980

ttggttttta cttaactgtt tcaaagccaa gacctcacac acacaaaaaa tgcacaaaca     2040

atgcaatcaa cagaaaagct gtaaatgtgt gtacagttgg catggtagta tacaaaaaga     2100

ttgtagtgga tctaattttt aagaaatttt gcctttaagt tattttacct gtttttgttt     2160

cttgttttga aagatgcgca ttctaacctg gaggtcaatg ttatgtattt atttatttat     2220

ttatttggtt cccttcctat tccaagcttc catagctgct gccctagttt tctttcctcc     2280

tttcctcctc tgacttgggg accttttggg ggagggctgc gacgcttgct ctgtttgtgg     2340

ggtgacggga ctcaggcggg acagtgctgc agctccctgg cttctgtggg gcccctcacc     2400

tacttaccca ggtgggtccc ggctctgtgg gtgatgggga ggggcattgc tgactgtgta     2460

tataggataa ttatgaaaag cagttctgga tggtgtgcct tccagatcct ctctggggct     2520

gtgttttgag cagcaggtag cctgctggtt ttatctgagt gaaatactgt acaggggaat     2580

aaaagagatc ttattttttt ttttatactt ggcgtttttt gaataaaaac cttttgtctt     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      2684


<210>  63
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Lys Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp 
1               5                   10                  15      


Ser Arg Thr Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala 
            20                  25                  30          


Asp Asp Leu Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val 
        35                  40                  45              


Val Glu Lys Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys 
    50                  55                  60                  


Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met 
65                  70                  75                  80  


Asp Leu Asp Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr 
                85                  90                  95      


Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu 
            100                 105                 110         


Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys 
        115                 120                 125             


Asn Met Thr Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile 
    130                 135                 140                 


Val Arg Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg 
145                 150                 155                 160 


Asp Val Lys Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys 
                165                 170                 175     


Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys 
            180                 185                 190         


Thr Met Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn 
        195                 200                 205             


Pro Glu Leu Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser 
    210                 215                 220                 


Leu Gly Ile Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu 
225                 230                 235                 240 


Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro 
                245                 250                 255     


Ser Pro Gln Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe 
            260                 265                 270         


Thr Ala Gln Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu 
        275                 280                 285             


Glu Leu Met Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr 
    290                 295                 300                 


Asp Ile Ala Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
305                 310                 315             


<210>  64
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  65
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gln Ser Thr Ala Asn Tyr Leu Trp His Thr Asp Asp Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Ser Val Tyr Lys Ala Arg Asn Lys Lys Ser Gly 
            20                  25                  30          


Glu Leu Val Ala Val Lys Val Phe Asn Thr Thr Ser Tyr Leu Arg Pro 
        35                  40                  45              


Arg Glu Val Gln Val Arg Glu Phe Glu Val Leu Arg Lys Leu Asn His 
    50                  55                  60                  


Gln Asn Ile Val Lys Leu Phe Ala Val Glu Glu Thr Gly Gly Ser Arg 
65                  70                  75                  80  


Gln Lys Val Leu Val Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser 
                85                  90                  95      


Val Leu Glu Ser Pro Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe 
            100                 105                 110         


Leu Val Val Leu Arg Cys Val Val Ala Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu 
    130                 135                 140                 


Val Gly Glu Glu Gly Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Asp Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Pro Gln Gln Lys Ala Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Leu Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe 
    210                 215                 220                 


Gly Gly Pro Arg Arg Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Ala Gly Ala Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro 
                245                 250                 255     


Leu Glu Trp Ser Tyr Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly 
            260                 265                 270         


Leu Gln Ser Gln Leu Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu 
        275                 280                 285             


Gln Ala Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu Gln Arg Val Val Val His Val Phe Ser Leu Ser Gln Ala Val 
305                 310                 315                 320 


Leu His His Ile Tyr Ile His Ala His Asn Thr Ile Ala Ile Phe Gln 
                325                 330                 335     


Glu Ala Val His Lys Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr 
            340                 345                 350         


Leu Phe Glu Gly His Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln 
        355                 360                 365             


His Ile Ala His Thr Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr 
    370                 375                 380                 


Ala Ile Pro Lys Gly Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro 
385                 390                 395                 400 


Lys Phe Val Pro Lys Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys 
                405                 410                 415     


Gly Val Leu Gly Ala Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu 
            420                 425                 430         


Leu Asp Gly Gln Glu Leu Met Phe Arg Gly Leu His Trp Val Met Glu 
        435                 440                 445             


Val Leu Gln Ala Thr Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser 
    450                 455                 460                 


Leu Leu Tyr Leu Ser Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val 
465                 470                 475                 480 


Ala Gly Thr Pro Glu Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg 
                485                 490                 495     


Ser Arg Leu Arg Thr Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn 
            500                 505                 510         


Ile Thr Glu Thr Gln Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val 
        515                 520                 525             


Lys Ser Arg Asp Gln Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln 
    530                 535                 540                 


Cys Cys Leu Asp Lys Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser 
545                 550                 555                 560 


Arg Met Arg Pro Gly Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu 
                565                 570                 575     


Asp Lys Val Asn Phe Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe 
            580                 585                 590         


Gln Glu Glu Cys Val Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly 
        595                 600                 605             


Lys Arg Met Arg Val Val His Glu Thr Arg Asn His Leu Arg Leu Val 
    610                 615                 620                 


Gly Cys Ser Val Ala Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu 
625                 630                 635                 640 


Ser Leu Ser Lys Leu Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp 
                645                 650                 655     


Arg Ala Lys Gly Ala Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro 
            660                 665                 670         


Ser Pro Thr Arg Lys Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu 
        675                 680                 685             


Gly Met Lys Leu Leu Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile 
    690                 695                 700                 


Glu Arg Leu Asn Arg Val Pro Ala Pro Pro Asp Val 
705                 710                 715     


<210>  66
<211>  4629
<212>  DNA
<213>  Homo sapiens

<400>  66
ggagagggag aaggctctcg ggcggagaga ggtcctgccc agctgttggc gaggagtttc       60

ctgtttcccc cgcagcgctg agttgaagtt gagtgagtca ctcgcgcgca cggagcgacg      120

acacccccgc gcgtgcaccc gctcgggaca ggagccggac tcctgtgcag cttccctcgg      180

ccgccggggg cctccccgcg cctcgccggc ctccaggccc cctcctggct ggcgagcggg      240

cgccacatct ggcccgcaca tctgcgctgc cggcccggcg cggggtccgg agagggcgcg      300

gcgcggaggc gcagccaggg gtccgggaag gcgccgtccg ctgcgctggg ggctcggtct      360

atgacgagca gcggggtctg ccatgggtcg ggggctgctc aggggcctgt ggccgctgca      420

catcgtcctg tggacgcgta tcgccagcac gatcccaccg cacgttcaga agtcggttaa      480

taacgacatg atagtcactg acaacaacgg tgcagtcaag tttccacaac tgtgtaaatt      540

ttgtgatgtg agattttcca cctgtgacaa ccagaaatcc tgcatgagca actgcagcat      600

cacctccatc tgtgagaagc cacaggaagt ctgtgtggct gtatggagaa agaatgacga      660

gaacataaca ctagagacag tttgccatga ccccaagctc ccctaccatg actttattct      720

ggaagatgct gcttctccaa agtgcattat gaaggaaaaa aaaaagcctg gtgagacttt      780

cttcatgtgt tcctgtagct ctgatgagtg caatgacaac atcatcttct cagaagaata      840

taacaccagc aatcctgact tgttgctagt catatttcaa gtgacaggca tcagcctcct      900

gccaccactg ggagttgcca tatctgtcat catcatcttc tactgctacc gcgttaaccg      960

gcagcagaag ctgagttcaa cctgggaaac cggcaagacg cggaagctca tggagttcag     1020

cgagcactgt gccatcatcc tggaagatga ccgctctgac atcagctcca cgtgtgccaa     1080

caacatcaac cacaacacag agctgctgcc cattgagctg gacaccctgg tggggaaagg     1140

tcgctttgct gaggtctata aggccaagct gaagcagaac acttcagagc agtttgagac     1200

agtggcagtc aagatctttc cctatgagga gtatgcctct tggaagacag agaaggacat     1260

cttctcagac atcaatctga agcatgagaa catactccag ttcctgacgg ctgaggagcg     1320

gaagacggag ttggggaaac aatactggct gatcaccgcc ttccacgcca agggcaacct     1380

acaggagtac ctgacgcggc atgtcatcag ctgggaggac ctgcgcaagc tgggcagctc     1440

cctcgcccgg gggattgctc acctccacag tgatcacact ccatgtggga ggcccaagat     1500

gcccatcgtg cacagggacc tcaagagctc caatatcctc gtgaagaacg acctaacctg     1560

ctgcctgtgt gactttgggc tttccctgcg tctggaccct actctgtctg tggatgacct     1620

ggctaacagt gggcaggtgg gaactgcaag atacatggct ccagaagtcc tagaatccag     1680

gatgaatttg gagaatgttg agtccttcaa gcagaccgat gtctactcca tggctctggt     1740

gctctgggaa atgacatctc gctgtaatgc agtgggagaa gtaaaagatt atgagcctcc     1800

atttggttcc aaggtgcggg agcacccctg tgtcgaaagc atgaaggaca acgtgttgag     1860

agatcgaggg cgaccagaaa ttcccagctt ctggctcaac caccagggca tccagatggt     1920

gtgtgagacg ttgactgagt gctgggacca cgacccagag gcccgtctca cagcccagtg     1980

tgtggcagaa cgcttcagtg agctggagca tctggacagg ctctcgggga ggagctgctc     2040

ggaggagaag attcctgaag acggctccct aaacactacc aaatagctct tctggggcag     2100

gctgggccat gtccaaagag gctgcccctc tcaccaaaga acagaggcag caggaagctg     2160

cccctgaact gatgcttcct ggaaaaccaa gggggtcact cccctccctg taagctgtgg     2220

ggataagcag aaacaacagc agcagggagt gggtgacata gagcattcta tgcctttgac     2280

attgtcatag gataagctgt gttagcactt cctcaggaaa tgagattgat ttttacaata     2340

gccaataaca tttgcacttt attaatgcct gtatataaat atgaatagct atgttttata     2400

tatatatata tatatctata tatgtctata gctctatata tatagccata ccttgaaaag     2460

agacaaggaa aaacatcaaa tattcccagg aaattggttt tattggagaa ctccagaacc     2520

aagcagagaa ggaagggacc catgacagca ttagcatttg acaatcacac atgcagtggt     2580

tctctgactg taaaacagtg aactttgcat gaggaaagag gctccatgtc tcacagccag     2640

ctatgaccac attgcacttg cttttgcaaa ataatcattc cctgcctagc acttctcttc     2700

tggccatgga actaagtaca gtggcactgt ttgaggacca gtgttcccgg ggttcctgtg     2760

tgcccttatt tctcctggac ttttcattta agctccaagc cccaaatctg gggggctagt     2820

ttagaaactc tccctcaacc tagtttagaa actctacccc atctttaata ccttgaatgt     2880

tttgaacccc actttttacc ttcatgggtt gcagaaaaat cagaacagat gtccccatcc     2940

atgcgattgc cccaccatct actaatgaaa aattgttctt tttttcatct ttcccctgca     3000

cttatgttac tattctctgc tcccagcctt catccttttc taaaaaggag caaattctca     3060

ctctaggctt tatcgtgttt actttttcat tacacttgac ttgattttct agttttctat     3120

acaaacacca atgggttcca tctttctggg ctcctgattg ctcaagcaca gtttggcctg     3180

atgaagagga tttcaactac acaatactat cattgtcagg actatgacct caggcactct     3240

aaacatatgt tttgtttggt cagcacagcg tttcaaaaag tgaagccact ttataaatat     3300

ttggagattt tgcaggaaaa tctggatccc caggtaagga tagcagatgg ttttcagtta     3360

tctccagtcc acgttcacaa aatgtgaagg tgtggagaca cttacaaagc tgcctcactt     3420

ctcactgtaa acattagctc tttccactgc ctacctggac cccagtctag gaattaaatc     3480

tgcacctaac caaggtccct tgtaagaaat gtccattcaa gcagtcattc tctgggtata     3540

taatatgatt ttgactacct tatctggtgt taagatttga agttggcctt ttattggact     3600

aaaggggaac tcctttaagg gtctcagtta gcccaagttt cttttgctta tatgttaata     3660

gttttaccct ctgcattgga gagaggagtg ctttactcca agaagctttc ctcatggtta     3720

ccgttctctc catcatgcca gccttctcaa cctttgcaga aattactaga gaggatttga     3780

atgtgggaca caaaggtccc atttgcagtt agaaaatttg tgtccacaag gacaagaaca     3840

aagtatgagc tttaaaactc cataggaaac ttgttaatca acaaagaagt gttaatgctg     3900

caagtaatct cttttttaaa actttttgaa gctacttatt ttcagccaaa taggaatatt     3960

agagagggac tggtagtgag aatatcagct ctgtttggat ggtggaaggt ctcattttat     4020

tgagattttt aagatacatg caaaggtttg gaaatagaac ctctaggcac cctcctcagt     4080

gtgggtgggc tgagagttaa agacagtgtg gctgcagtag catagaggcg cctagaaatt     4140

ccacttgcac cgtagggcat gctgatacca tcccaatagc tgttgcccat tgacctctag     4200

tggtgagttt ctagaatact ggtccattca tgagatattc aagattcaag agtattctca     4260

cttctgggtt atcagcataa actggaatgt agtgtcagag gatactgtgg cttgttttgt     4320

ttatgttttt ttttcttatt caagaaaaaa gaccaaggaa taacattctg tagttcctaa     4380

aaatactgac ttttttcact actatacata aagggaaagt tttattcttt tatggaacac     4440

ttcagctgta ctcatgtatt aaaataggaa tgtgaatgct atatactctt tttatatcaa     4500

aagtctcaag cacttatttt tattctatgc attgtttgtc ttttacataa ataaaatgtt     4560

tattagattg aataaagcaa aatactcagg tgagcatcct gcctcctgtt cccattccta     4620

gtagctaaa                                                             4629


<210>  67
<211>  236
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (229)..(229)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (233)..(233)
<223>  n is a, c, g, t or u

<400>  67
makydsvccd vskykakggt gvkarhrktg kvakkvmnkg tarkkhnvvn crtkasynrc       60

kgsyvdchda gsnvvktskr vmmngyyhrn khrdmkaanv trdgvkadga rasaknsnry      120

tnrvvtwyrg rdygdwgagc mamwtrsmgn thascgstvw nvdnyykvkg krkvkdrkay      180

vrdyaddkvd ardsddanhd wsdmsdkgms thtsmyarrk gststnsrna ttntrv          236


<210>  68
<211>  2524
<212>  DNA
<213>  Homo sapiens

<400>  68
ggcgacggcg ctgccgccat tttgtggggt gtttgtcgca gcggccgagg agggaagacg       60

gcagtttggc gacatttctc ggccgaaggg ccatttgctt ttgcggagat gcggcattcc      120

aaaagaactc actgtcctga ttgggatagc agagaaagct ggggacatga aagctatcgt      180

ggaagtcaca agcggaagag gagatctcat agtagcacac aagagaacag gcattgtaaa      240

ccacatcacc agtttaaaga atctgattgt cattatttag aagcaaggtc cttgaatgag      300

cgagattatc gggaccggag atacgttgac gaatacagga atgactactg tgaaggatat      360

gttcctagac attatcacag agacattgaa agcgggtatc gaatccactg cagtaaatct      420

tcagtccgca gcaggagaag cagtcctaaa aggaagcgca atagacactg ttcaagtcat      480

cagtcacgtt cgaagagcca ccgaaggaaa agatccagga gtatagagga tgatgaggag      540

ggtcacctga tctgtcaaag tggagacgtt ctaagagcaa gatatgaaat cgtggacact      600

ttgggtgaag gagcctttgg caaagttgta gagtgcattg atcatggcat ggatggcatg      660

catgtagcag tgaaaatcgt aaaaaatgta ggccgttacc gtgaagcagc tcgttcagaa      720

atccaagtat tagagcactt aaatagtact gatcccaata gtgtcttccg atgtgtccag      780

atgctagaat ggtttgatca tcatggtcat gtttgtattg tgtttgaact actgggactt      840

agtacttacg atttcattaa agaaaacagc tttctgccat ttcaaattga ccacatcagg      900

cagatggcgt atcagatctg ccagtcaata aattttttac atcataataa attaacccat      960

acagatctga agcctgaaaa tattttgttt gtgaagtctg actatgtagt caaatataat     1020

tctaaaatga aacgtgatga acgcacactg aaaaacacag atatcaaagt tgttgacttt     1080

ggaagtgcaa cgtatgatga tgaacatcac agtactttgg tgtctacccg gcactacaga     1140

gctcccgagg tcattttggc tttaggttgg tctcagcctt gtgatgtttg gagcataggt     1200

tgcattctta ttgaatatta ccttggtttc acagtctttc agactcatga tagtaaagag     1260

cacctggcaa tgatggaacg aatattagga cccataccac aacacatgat tcagaaaaca     1320

agaaaacgca agtattttca ccataaccag ctagattggg atgaacacag ttctgctggt     1380

agatatgtta ggagacgctg caaaccgttg aaggaattta tgctttgtca tgatgaagaa     1440

catgagaaac tgtttgacct ggttcgaaga atgttagaat atgatccaac tcaaagaatt     1500

accttggatg aagcattgca gcatcctttc tttgacttat taaaaaagaa atgaaatggg     1560

aatcagtggt cttactatat acttctctag aagagattac ttaagactgt gtcagtcaac     1620

taaacattct aatatttttg taaacattaa attattttgt acagttaagt gtaaatattg     1680

tatgttttgt atcaatagca taattaactt gttaagcaag tatggtcttg ataatgcatt     1740

agaaaaatta aaattaattt ttctttttga aattaccatt tttaaatacc tttgaaatat     1800

cctttgtgtc cagtgataaa tgtgattgat cttgcctttt gtacatggag gtcacctctg     1860

aagtgatttt ttttgagtaa aaggaaatct tgactacttt atattcttaa aggaatattc     1920

tttatatact tcaaatttag aacttaactt taaaagtttt tcttctgtaa ttgttgaacg     1980

ggtgattatt attaactcta gataagcagg tactagaaac caaaactcag aaaatgttta     2040

ctgttagaat tctattaaat tttaagtgtt gtattctttt tcattgggtg atgtcagggt     2100

gataaccaga cattcatgga aaggcatgca gtttgtccat tgtgacagtt tgtttaataa     2160

aaccacatac acactttatt taagattaaa atctaactgg aaagtcagct tggaaaatgg     2220

acatttccaa gtatgtttgg tgagtcacag atataaaaat agaaattctg atgagaggtt     2280

tcagttttta ataccaagtc cttaggagtc ttaacattgg ccagcatctg tttatcaaat     2340

gacataaata cgtaaaccta taagaattaa gtttattaat taggcaattt atgtctgtga     2400

taattcttac gggagaaaga ggatttgatt ggaaagcagt ttgggaagaa agtgctgctg     2460

aaatttccag aatttaattg attggttaca taaacttttt gacttcaaaa aaaaaaaaaa     2520

aaaa                                                                  2524


<210>  69
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ile Met Asn Lys Met Lys Asn Phe Lys Arg Arg Phe Ser Leu Ser 
1               5                   10                  15      


Val Pro Arg Thr Glu Thr Ile Glu Glu Ser Leu Ala Glu Phe Thr Glu 
            20                  25                  30          


Gln Phe Asn Gln Leu His Asn Arg Arg Asn Glu Asn Leu Gln Leu Gly 
        35                  40                  45              


Pro Leu Gly Arg Asp Pro Pro Gln Glu Cys Ser Thr Phe Ser Pro Thr 
    50                  55                  60                  


Asp Ser Gly Glu Glu Pro Gly Gln Leu Ser Pro Gly Val Gln Phe Gln 
65                  70                  75                  80  


Arg Arg Gln Asn Gln Arg Arg Phe Ser Met Glu Asp Val Ser Lys Arg 
                85                  90                  95      


Leu Ser Leu Pro Met Asp Ile Arg Leu Pro Gln Glu Phe Leu Gln Lys 
            100                 105                 110         


Leu Gln Met Glu Ser Pro Asp Leu Pro Lys Pro Leu Ser Arg Met Ser 
        115                 120                 125             


Arg Arg Ala Ser Leu Ser Asp Ile Gly Phe Gly Lys Leu Glu Thr Tyr 
    130                 135                 140                 


Val Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val Phe Lys 
145                 150                 155                 160 


Gly Arg Ser Lys Leu Thr Glu Asn Leu Val Ala Leu Lys Glu Ile Arg 
                165                 170                 175     


Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu Val Ser 
            180                 185                 190         


Leu Leu Lys Asn Leu Lys His Ala Asn Ile Val Thr Leu His Asp Leu 
        195                 200                 205             


Ile His Thr Asp Arg Ser Leu Thr Leu Val Phe Glu Tyr Leu Asp Ser 
    210                 215                 220                 


Asp Leu Lys Gln Tyr Leu Asp His Cys Gly Asn Leu Met Ser Met His 
225                 230                 235                 240 


Asn Val Lys Ile Phe Met Phe Gln Leu Leu Arg Gly Leu Ala Tyr Cys 
                245                 250                 255     


His His Arg Lys Ile Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu 
            260                 265                 270         


Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg 
        275                 280                 285             


Ala Lys Ser Val Pro Thr Lys Thr Tyr Ser Asn Glu Val Val Thr Leu 
    290                 295                 300                 


Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Thr Glu Tyr Ser Thr 
305                 310                 315                 320 


Pro Ile Asp Met Trp Gly Val Gly Cys Ile His Tyr Glu Met Ala Thr 
                325                 330                 335     


Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Lys Glu Glu Leu His Leu 
            340                 345                 350         


Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu Glu Thr Trp Pro Gly Val 
        355                 360                 365             


Thr Ala Phe Ser Glu Phe Arg Thr Tyr Ser Phe Pro Cys Tyr Leu Pro 
    370                 375                 380                 


Gln Pro Leu Ile Asn His Ala Pro Arg Leu Asp Thr Asp Gly Ile His 
385                 390                 395                 400 


Leu Leu Ser Ser Leu Leu Leu Tyr Glu Ser Lys Ser Arg Met Ser Ala 
                405                 410                 415     


Glu Ala Ala Leu Ser His Ser Tyr Phe Arg Ser Leu Gly Glu Arg Val 
            420                 425                 430         


His Gln Leu Glu Asp Thr Ala Ser Ile Phe Ser Leu Lys Glu Ile Gln 
        435                 440                 445             


Leu Gln Lys Asp Pro Gly Tyr Arg Gly Leu Ala Phe Gln Gln Pro Gly 
    450                 455                 460                 


Arg Gly Lys Asn Arg Arg Gln Ser Ile Phe 
465                 470                 


<210>  70
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Gly Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
465                 470                 475                 480 


Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                485                 490                 495     


Gln Asn Ile 
            


<210>  71
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Cys Thr Val Val Asp Pro Arg Ile Val Arg Arg Tyr Leu Leu Arg 
1               5                   10                  15      


Arg Gln Leu Gly Gln Gly Ala Tyr Gly Ile Val Trp Lys Ala Val Asp 
            20                  25                  30          


Arg Arg Thr Gly Glu Val Val Ala Ile Lys Lys Ile Phe Asp Ala Phe 
        35                  40                  45              


Arg Asp Lys Thr Asp Ala Gln Arg Thr Phe Arg Glu Ile Thr Leu Leu 
    50                  55                  60                  


Gln Glu Phe Gly Asp His Pro Asn Ile Ile Ser Leu Leu Asp Val Ile 
65                  70                  75                  80  


Arg Ala Glu Asn Asp Arg Asp Ile Tyr Leu Val Phe Glu Phe Met Asp 
                85                  90                  95      


Thr Asp Leu Asn Ala Val Ile Arg Lys Gly Gly Leu Leu Gln Asp Val 
            100                 105                 110         


His Val Arg Ser Ile Phe Tyr Gln Leu Leu Arg Ala Thr Arg Phe Leu 
        115                 120                 125             


His Ser Gly His Val Val His Arg Asp Gln Lys Pro Ser Asn Val Leu 
    130                 135                 140                 


Leu Asp Ala Asn Cys Thr Val Lys Leu Cys Asp Phe Gly Leu Ala Arg 
145                 150                 155                 160 


Ser Leu Gly Asp Leu Pro Glu Gly Pro Glu Asp Gln Ala Val Thr Glu 
                165                 170                 175     


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Ser Ser 
            180                 185                 190         


His Arg Tyr Thr Leu Gly Val Asp Met Trp Ser Leu Gly Cys Ile Leu 
        195                 200                 205             


Gly Glu Met Leu Arg Gly Arg Pro Leu Phe Pro Gly Thr Ser Thr Leu 
    210                 215                 220                 


His Gln Leu Glu Leu Ile Leu Glu Thr Ile Pro Pro Pro Ser Glu Glu 
225                 230                 235                 240 


Asp Leu Leu Ala Leu Gly Ser Gly Cys Arg Ala Ser Val Leu His Gln 
                245                 250                 255     


Leu Gly Ser Arg Pro Arg Gln Thr Leu Asp Ala Leu Leu Pro Pro Asp 
            260                 265                 270         


Thr Ser Pro Glu Ala Leu Asp Leu Leu Arg Arg Leu Leu Val Phe Ala 
        275                 280                 285             


Pro Asp Lys Arg Leu Ser Ala Thr Gln Ala Leu Gln His Pro Tyr Val 
    290                 295                 300                 


Gln Arg Phe His Cys Pro Ser Asp Glu Trp Ala Arg Glu Ala Asp Val 
305                 310                 315                 320 


Arg Pro Arg Ala His Glu Gly Val Gln Leu Ser Val Pro Glu Tyr Arg 
                325                 330                 335     


Ser Arg Val Tyr Gln Met Ile Leu Glu Cys Gly Gly Ser Ser Gly Thr 
            340                 345                 350         


Ser Arg Glu Lys Gly Pro Glu Gly Val Ser Pro Ser Gln Ala His Leu 
        355                 360                 365             


His Lys Pro Arg Ala Asp Pro Gln Leu Pro Ser Arg Thr Pro Val Gln 
    370                 375                 380                 


Gly Pro Arg Pro Arg Pro Gln Ser Ser Pro Gly His Asp Pro Ala Glu 
385                 390                 395                 400 


His Glu Ser Pro Arg Ala Ala Lys Asn Val Pro Arg Gln Asn Ser Ala 
                405                 410                 415     


Pro Leu Leu Gln Thr Ala Leu Leu Gly Asn Gly Glu Arg Pro Pro Gly 
            420                 425                 430         


Ala Lys Glu Ala Pro Pro Leu Thr Leu Ser Leu Val Lys Pro Ser Gly 
        435                 440                 445             


Arg Gly Ala Ala Pro Ser Leu Thr Ser Gln Ala Ala Ala Gln Val Ala 
    450                 455                 460                 


Asn Gln Ala Leu Ile Arg Gly Asp Trp Asn Arg Gly Gly Gly Val Arg 
465                 470                 475                 480 


Val Ala Ser Val Gln Gln Val Pro Pro Arg Leu Pro Pro Glu Ala Arg 
                485                 490                 495     


Pro Gly Arg Arg Met Phe Ser Thr Ser Ala Leu Gln Gly Ala Gln Gly 
            500                 505                 510         


Gly Ala Arg Ala Leu Leu Gly Gly Tyr Ser Gln Ala Tyr Gly Thr Val 
        515                 520                 525             


Cys His Ser Ala Leu Gly His Leu Pro Leu Leu Glu Gly His His Val 
    530                 535                 540                 


<210>  72
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Thr Ser Thr Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Thr Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Thr Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Thr Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Thr Ser Pro Leu Ser Ser Pro Arg Val Thr Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Thr Pro Lys Gly Thr Pro 
        435                 440                 445             


Val His Thr Pro Lys Glu Ser Pro Ala Gly Thr Pro Asn Pro Thr Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Thr Pro Glu Glu Met Ser Asn Leu Thr Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Thr Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Thr Tyr Thr Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Thr Phe Thr Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Asp Thr Thr Asn Cys Met Glu Met Met Thr 
                645                 650                 655     


Gly Arg Leu Ser Lys Cys Gly Ile Ile Pro Lys Ser 
            660                 665             


<210>  73
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Leu Gly Ala Val Glu Gly Pro Arg Trp Lys Gln Ala Glu Asp Ile 
1               5                   10                  15      


Arg Asp Ile Tyr Asp Phe Arg Asp Val Leu Gly Thr Gly Ala Phe Ser 
            20                  25                  30          


Glu Val Ile Leu Ala Glu Asp Lys Arg Thr Gln Lys Leu Val Ala Ile 
        35                  40                  45              


Lys Cys Ile Ala Lys Glu Ala Leu Glu Gly Lys Glu Gly Ser Met Glu 
    50                  55                  60                  


Asn Glu Ile Ala Val Leu His Lys Ile Lys His Pro Asn Ile Val Ala 
65                  70                  75                  80  


Leu Asp Asp Ile Tyr Glu Ser Gly Gly His Leu Tyr Leu Ile Met Gln 
                85                  90                  95      


Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu Lys Gly Phe 
            100                 105                 110         


Tyr Thr Glu Arg Asp Ala Ser Arg Leu Ile Phe Gln Val Leu Asp Ala 
        115                 120                 125             


Val Lys Tyr Leu His Asp Leu Gly Ile Val His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Tyr Tyr Ser Leu Asp Glu Asp Ser Lys Ile Met Ile 
145                 150                 155                 160 


Ser Asp Phe Gly Leu Ser Lys Met Glu Asp Pro Gly Ser Val Leu Ser 
                165                 170                 175     


Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala Gln 
            180                 185                 190         


Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile Ala 
        195                 200                 205             


Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu Asn Asp Ala 
    210                 215                 220                 


Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe Asp Ser Pro 
225                 230                 235                 240 


Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile Arg His Leu 
                245                 250                 255     


Met Glu Lys Asp Pro Glu Lys Arg Phe Thr Cys Glu Gln Ala Leu Gln 
            260                 265                 270         


His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asp Lys Asn Ile His Gln 
        275                 280                 285             


Ser Val Ser Glu Gln Ile Lys Lys Asn Phe Ala Lys Ser Lys Trp Lys 
    290                 295                 300                 


Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg Lys Leu Gln 
305                 310                 315                 320 


Leu Gly Thr Ser Gln Glu Gly Gln Gly Gln Thr Ala Ser His Gly Glu 
                325                 330                 335     


Leu Leu Thr Pro Val Ala Gly Gly Pro Ala Ala Gly Cys Cys Cys Arg 
            340                 345                 350         


Asp Cys Cys Val Glu Pro Gly Thr Glu Leu Ser Pro Thr Leu Pro His 
        355                 360                 365             


Gln Leu 
    370 


<210>  74
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  75
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  76
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr 
1               5                   10                  15      


Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile 
            20                  25                  30          


Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn 
        35                  40                  45              


Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu 
    50                  55                  60                  


Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr 
65                  70                  75                  80  


Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu 
            100                 105                 110         


Glu Met Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp 
        115                 120                 125             


Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Leu Leu Asp Ala His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser 
                165                 170                 175     


Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly 
            180                 185                 190         


Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu 
        195                 200                 205             


Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys 
    210                 215                 220                 


Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser 
225                 230                 235                 240 


Val Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg 
                245                 250                 255     


Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu 
            260                 265                 270         


Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile 
        275                 280                 285             


Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu 
    290                 295                 300                 


Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu 
305                 310                 315                 320 


Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln 
                325                 330                 335     


Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Ser Gly Ser Phe Met 
            340                 345                 350         


Asp Asp Ser Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu 
        355                 360                 365             


Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu 
    370                 375                 380                 


Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala 
385                 390                 395                 400 


Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met 
                405                 410                 415     


Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val 
            420                 425                 430         


Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly 
        435                 440                 445             


Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser 
    450                 455                 460                 


Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg 
465                 470                 475                 480 


Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His 
                485                 490                 495     


Arg Pro Arg Ser Ser Phe Asp Ser Thr Thr Ala Glu Ser His Ser Leu 
            500                 505                 510         


Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Val 
        515                 520                 525             


Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala 
    530                 535                 540                 


Ser Leu Ile Thr Thr Leu Ala Arg 
545                 550         


<210>  77
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ser Phe Phe Asn Phe Arg Lys Ile Phe Lys Leu Gly Ser Glu Lys 
1               5                   10                  15      


Lys Lys Lys Gln Tyr Glu His Val Lys Arg Asp Leu Asn Pro Glu Asp 
            20                  25                  30          


Phe Trp Glu Ile Ile Gly Glu Leu Gly Asp Gly Ala Phe Gly Lys Val 
        35                  40                  45              


Tyr Lys Ala Gln Asn Lys Glu Thr Ser Val Leu Ala Ala Ala Lys Val 
    50                  55                  60                  


Ile Asp Thr Lys Ser Glu Glu Glu Leu Glu Asp Tyr Met Val Glu Ile 
65                  70                  75                  80  


Asp Ile Leu Ala Ser Cys Asp His Pro Asn Ile Val Lys Leu Leu Asp 
                85                  90                  95      


Ala Phe Tyr Tyr Glu Asn Asn Leu Trp Ile Leu Ile Glu Phe Cys Ala 
            100                 105                 110         


Gly Gly Ala Val Asp Ala Val Met Leu Glu Leu Glu Arg Pro Leu Thr 
        115                 120                 125             


Glu Ser Gln Ile Gln Val Val Cys Lys Gln Thr Leu Asp Ala Leu Asn 
    130                 135                 140                 


Tyr Leu His Asp Asn Lys Ile Ile His Arg Asp Leu Lys Ala Gly Asn 
145                 150                 155                 160 


Ile Leu Phe Thr Leu Asp Gly Asp Ile Lys Leu Ala Asp Phe Gly Val 
                165                 170                 175     


Ser Ala Lys Asn Thr Arg Thr Ile Gln Arg Arg Asp Ser Phe Ile Gly 
            180                 185                 190         


Thr Pro Tyr Trp Met Ala Pro Glu Val Val Met Cys Glu Thr Ser Lys 
        195                 200                 205             


Asp Arg Pro Tyr Asp Tyr Lys Ala Asp Val Trp Ser Leu Gly Ile Thr 
    210                 215                 220                 


Leu Ile Glu Met Ala Glu Ile Glu Pro Pro His His Glu Leu Asn Pro 
225                 230                 235                 240 


Met Arg Val Leu Leu Lys Ile Ala Lys Ser Glu Pro Pro Thr Leu Ala 
                245                 250                 255     


Gln Pro Ser Arg Trp Ser Ser Asn Phe Lys Asp Phe Leu Lys Lys Cys 
            260                 265                 270         


Leu Glu Lys Asn Val Asp Ala Arg Trp Thr Thr Ser Gln Leu Leu Gln 
        275                 280                 285             


His Pro Phe Val Thr Val Asp Ser Asn Lys Pro Ile Arg Glu Leu Ile 
    290                 295                 300                 


Ala Glu Ala Lys Ala Glu Val Thr Glu Glu Val Glu Asp Gly Lys Glu 
305                 310                 315                 320 


Glu Asp Glu Glu Glu Glu Thr Glu Asn Ser Leu Pro Ile Pro Ala Ser 
                325                 330                 335     


Lys Arg Ala Ser Ser Asp Leu Ser Ile Ala Ser Ser Glu Glu Asp Lys 
            340                 345                 350         


Leu Ser Gln Asn Ala Cys Ile Leu Glu Ser Val Ser Glu Lys Thr Glu 
        355                 360                 365             


Arg Ser Asn Ser Glu Asp Lys Leu Asn Ser Lys Ile Leu Asn Glu Lys 
    370                 375                 380                 


Pro Thr Thr Asp Glu Pro Glu Lys Ala Val Glu Asp Ile Asn Glu His 
385                 390                 395                 400 


Ile Thr Asp Ala Gln Leu Glu Ala Met Thr Glu Leu His Asp Arg Thr 
                405                 410                 415     


Ala Val Ile Lys Glu Asn Glu Arg Glu Lys Arg Pro Lys Leu Glu Asn 
            420                 425                 430         


Leu Pro Asp Thr Glu Asp Gln Glu Thr Val Asp Ile Asn Ser Val Ser 
        435                 440                 445             


Glu Gly Lys Glu Asn Asn Ile Met Ile Thr Leu Glu Thr Asn Ile Glu 
    450                 455                 460                 


His Asn Leu Lys Ser Glu Glu Glu Lys Asp Gln Glu Lys Gln Gln Met 
465                 470                 475                 480 


Phe Glu Asn Lys Leu Ile Lys Ser Glu Glu Ile Lys Asp Thr Ile Leu 
                485                 490                 495     


Gln Thr Val Asp Leu Val Ser Gln Glu Thr Gly Glu Lys Glu Ala Asn 
            500                 505                 510         


Ile Gln Ala Val Asp Ser Glu Val Gly Leu Thr Lys Glu Asp Thr Gln 
        515                 520                 525             


Glu Lys Leu Gly Glu Asp Asp Lys Thr Gln Lys Asp Val Ile Ser Asn 
    530                 535                 540                 


Thr Ser Asp Val Ile Gly Thr Cys Glu Ala Ala Asp Val Ala Gln Lys 
545                 550                 555                 560 


Val Asp Glu Asp Ser Ala Glu Asp Thr Gln Ser Asn Asp Gly Lys Glu 
                565                 570                 575     


Val Val Glu Val Gly Gln Lys Leu Ile Asn Lys Pro Met Val Gly Pro 
            580                 585                 590         


Glu Ala Gly Gly Thr Lys Glu Val Pro Ile Lys Glu Ile Val Glu Met 
        595                 600                 605             


Asn Glu Ile Glu Glu Gly Lys Asn Lys Glu Gln Ala Ile Asn Ser Ser 
    610                 615                 620                 


Glu Asn Ile Met Asp Ile Asn Glu Glu Pro Gly Thr Thr Glu Gly Glu 
625                 630                 635                 640 


Glu Ile Thr Glu Ser Ser Ser Thr Glu Glu Met Glu Val Arg Ser Val 
                645                 650                 655     


Val Ala Asp Thr Asp Gln Lys Ala Leu Gly Ser Glu Val Gln Asp Ala 
            660                 665                 670         


Ser Lys Val Thr Thr Gln Ile Asp Lys Glu Lys Lys Glu Ile Pro Val 
        675                 680                 685             


Ser Ile Lys Lys Glu Pro Glu Val Thr Val Val Ser Gln Pro Thr Glu 
    690                 695                 700                 


Pro Gln Pro Val Leu Ile Pro Ser Ile Asn Ile Asn Ser Asp Ser Gly 
705                 710                 715                 720 


Glu Asn Lys Glu Glu Ile Gly Ser Leu Ser Lys Thr Glu Thr Ile Leu 
                725                 730                 735     


Pro Pro Glu Ser Glu Asn Pro Lys Glu Asn Asp Asn Asp Ser Gly Thr 
            740                 745                 750         


Gly Ser Thr Ala Asp Thr Ser Ser Ile Asp Leu Asn Leu Ser Ile Ser 
        755                 760                 765             


Ser Phe Leu Ser Lys Thr Lys Asp Ser Gly Ser Ile Ser Leu Gln Glu 
    770                 775                 780                 


Thr Arg Arg Gln Lys Lys Thr Leu Lys Lys Thr Arg Lys Phe Ile Val 
785                 790                 795                 800 


Asp Gly Val Glu Val Ser Val Thr Thr Ser Lys Ile Val Thr Asp Ser 
                805                 810                 815     


Asp Ser Lys Thr Glu Glu Leu Arg Phe Leu Arg Arg Gln Glu Leu Arg 
            820                 825                 830         


Glu Leu Arg Phe Leu Gln Lys Glu Glu Gln Arg Ala Gln Gln Gln Leu 
        835                 840                 845             


Asn Ser Lys Leu Gln Gln Gln Arg Glu Gln Ile Phe Arg Arg Phe Glu 
    850                 855                 860                 


Gln Glu Met Met Ser Lys Lys Arg Gln Tyr Asp Gln Glu Ile Glu Asn 
865                 870                 875                 880 


Leu Glu Lys Gln Gln Lys Gln Thr Ile Glu Arg Leu Glu Gln Glu His 
                885                 890                 895     


Thr Asn Arg Leu Arg Asp Glu Ala Lys Arg Ile Lys Gly Glu Gln Glu 
            900                 905                 910         


Lys Glu Leu Ser Lys Phe Gln Asn Met Leu Lys Asn Arg Lys Lys Glu 
        915                 920                 925             


Val Ile Asn Glu Val Glu Lys Ala Pro Lys Glu Leu Arg Lys Glu Leu 
    930                 935                 940                 


Met Lys Arg Arg Lys Glu Glu Leu Ala Gln Ser Gln His Ala Gln Glu 
945                 950                 955                 960 


Gln Glu Phe Val Gln Lys Gln Gln Gln Glu Leu Asp Gly Ser Leu Lys 
                965                 970                 975     


Lys Ile Ile Gln Gln Gln Lys Ala Glu Leu Ala Asn Ile Glu Arg Glu 
            980                 985                 990         


Cys Leu Asn Asn Lys Gln Gln Leu  Met Arg Ala Arg Glu  Ala Ala Ile 
        995                 1000                 1005             


Trp Glu  Leu Glu Glu Arg His  Leu Gln Glu Lys His  Gln Leu Leu 
    1010                 1015                 1020             


Lys Gln  Gln Leu Lys Asp Gln  Tyr Phe Met Gln Arg  His Gln Leu 
    1025                 1030                 1035             


Leu Lys  Arg His Glu Lys Glu  Thr Glu Gln Met Gln  Arg Tyr Asn 
    1040                 1045                 1050             


Gln Arg  Leu Ile Glu Glu Leu  Lys Asn Arg Gln Thr  Gln Glu Arg 
    1055                 1060                 1065             


Ala Arg  Leu Pro Lys Ile Gln  Arg Ser Glu Ala Lys  Thr Arg Met 
    1070                 1075                 1080             


Ala Met  Phe Lys Lys Ser Leu  Arg Ile Asn Ser Thr  Ala Thr Pro 
    1085                 1090                 1095             


Asp Gln  Asp Arg Asp Lys Ile  Lys Gln Phe Ala Ala  Gln Glu Glu 
    1100                 1105                 1110             


Lys Arg  Gln Lys Asn Glu Arg  Met Ala Gln His Gln  Lys His Glu 
    1115                 1120                 1125             


Asn Gln  Met Arg Asp Leu Gln  Leu Gln Cys Glu Ala  Asn Val Arg 
    1130                 1135                 1140             


Glu Leu  His Gln Leu Gln Asn  Glu Lys Cys His Leu  Leu Val Glu 
    1145                 1150                 1155             


His Glu  Thr Gln Lys Leu Lys  Glu Leu Asp Glu Glu  His Ser Gln 
    1160                 1165                 1170             


Glu Leu  Lys Glu Trp Arg Glu  Lys Leu Arg Pro Arg  Lys Lys Thr 
    1175                 1180                 1185             


Leu Glu  Glu Glu Phe Ala Arg  Lys Leu Gln Glu Gln  Glu Val Phe 
    1190                 1195                 1200             


Phe Lys  Met Thr Gly Glu Ser  Glu Cys Leu Asn Pro  Ser Thr Gln 
    1205                 1210                 1215             


Ser Arg  Ile Ser Lys Phe Tyr  Pro Ile Pro Ser Leu  His Ser Thr 
    1220                 1225                 1230             


Gly Ser  
    1235 


<210>  78
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Gly Ala Ala Ala Pro Val Ala Gly Asp Arg Pro Asp Leu Gly 
1               5                   10                  15      


Leu Gly Ala Pro Gly Ser Pro Arg Glu Ala Val Ala Gly Ala Thr Ala 
            20                  25                  30          


Ala Leu Glu Pro Arg Lys Pro His Gly Val Lys Arg His His His Lys 
        35                  40                  45              


His Asn Leu Lys His Arg Tyr Glu Leu Gln Glu Thr Leu Gly Lys Gly 
    50                  55                  60                  


Thr Tyr Gly Lys Val Lys Arg Ala Thr Glu Arg Phe Ser Gly Arg Val 
65                  70                  75                  80  


Val Ala Ile Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp 
                85                  90                  95      


Met Val His Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His 
            100                 105                 110         


Pro His Ile Ile Ser Ile Tyr Glu Val Phe Glu Asn Lys Asp Lys Ile 
        115                 120                 125             


Val Ile Ile Met Glu Tyr Ala Ser Lys Gly Glu Leu Tyr Asp Tyr Ile 
    130                 135                 140                 


Ser Glu Arg Arg Arg Leu Ser Glu Arg Glu Thr Arg His Phe Phe Arg 
145                 150                 155                 160 


Gln Ile Val Ser Ala Val His Tyr Cys His Lys Asn Gly Val Val His 
                165                 170                 175     


Arg Asp Leu Lys Leu Glu Asn Ile Leu Leu Asp Asp Asn Cys Asn Ile 
            180                 185                 190         


Lys Ile Ala Asp Phe Gly Leu Ser Asn Leu Tyr Gln Lys Asp Lys Phe 
        195                 200                 205             


Leu Gln Thr Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu Ile Val 
    210                 215                 220                 


Asn Gly Arg Pro Tyr Arg Gly Pro Glu Val Asp Ser Trp Ala Leu Gly 
225                 230                 235                 240 


Val Leu Leu Tyr Thr Leu Val Tyr Gly Thr Met Pro Phe Asp Gly Phe 
                245                 250                 255     


Asp His Lys Asn Leu Ile Arg Gln Ile Ser Ser Gly Glu Tyr Arg Glu 
            260                 265                 270         


Pro Thr Gln Pro Ser Asp Ala Arg Gly Leu Ile Arg Trp Met Leu Met 
        275                 280                 285             


Val Asn Pro Asp Arg Arg Ala Thr Ile Glu Asp Ile Ala Asn His Trp 
    290                 295                 300                 


Trp Val Asn Trp Gly Tyr Lys Ser Ser Val Cys Asp Cys Asp Ala Leu 
305                 310                 315                 320 


His Asp Ser Glu Ser Pro Leu Leu Ala Arg Ile Ile Asp Trp His His 
                325                 330                 335     


Arg Ser Thr Gly Leu Gln Ala Asp Thr Glu Ala Lys Met Lys Gly Leu 
            340                 345                 350         


Ala Lys Pro Thr Thr Ser Glu Val Met Leu Glu Arg Gln Arg Ser Leu 
        355                 360                 365             


Lys Lys Ser Lys Lys Glu Asn Asp Phe Ala Gln Ser Gly Gln Asp Ala 
    370                 375                 380                 


Val Pro Glu Ser Pro Ser Lys Leu Ser Ser Lys Arg Pro Lys Gly Ile 
385                 390                 395                 400 


Leu Lys Lys Arg Ser Asn Ser Glu His Arg Ser His Ser Thr Gly Phe 
                405                 410                 415     


Ile Glu Gly Val Val Gly Pro Ala Leu Pro Ser Thr Phe Lys Met Glu 
            420                 425                 430         


Gln Asp Leu Cys Arg Thr Gly Val Leu Leu Pro Ser Ser Pro Glu Ala 
        435                 440                 445             


Glu Val Pro Gly Lys Leu Ser Pro Lys Gln Ser Ala Thr Met Pro Lys 
    450                 455                 460                 


Lys Gly Ile Leu Lys Lys Thr Gln Gln Arg Glu Ser Gly Tyr Tyr Ser 
465                 470                 475                 480 


Ser Pro Glu Arg Ser Glu Ser Ser Glu Leu Leu Asp Ser Asn Asp Val 
                485                 490                 495     


Met Gly Ser Ser Ile Pro Ser Pro Ser Pro Pro Asp Pro Ala Arg Val 
            500                 505                 510         


Thr Ser His Ser Leu Ser Cys Arg Arg Lys Gly Ile Leu Lys His Ser 
        515                 520                 525             


Ser Lys Tyr Ser Ala Gly Thr Met Asp Pro Ala Leu Val Ser Pro Glu 
    530                 535                 540                 


Met Pro Thr Leu Glu Ser Leu Ser Glu Pro Gly Val Pro Ala Glu Gly 
545                 550                 555                 560 


Leu Ser Arg Ser Tyr Ser Arg Pro Ser Ser Val Ile Ser Asp Asp Ser 
                565                 570                 575     


Val Leu Ser Ser Asp Ser Phe Asp Leu Leu Asp Leu Gln Glu Asn Arg 
            580                 585                 590         


Pro Ala Arg Gln Arg Ile Arg Ser Cys Val Ser Ala Glu Asn Phe Leu 
        595                 600                 605             


Gln Ile Gln Asp Phe Glu Gly Leu Gln Asn Arg Pro Arg Pro Gln Tyr 
    610                 615                 620                 


Leu Lys Arg Tyr Arg Asn Arg Leu Ala Asp Ser Ser Phe Ser Leu Leu 
625                 630                 635                 640 


Thr Asp Met Asp Asp Val Thr Gln Val Tyr Lys Gln Ala Leu Glu Ile 
                645                 650                 655     


Cys Ser Lys Leu Asn 
            660     


<210>  79
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210>  80
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser Ser Gly Ala Lys Glu Gly Gly Gly Gly Ser Pro Ala Tyr His 
1               5                   10                  15      


Leu Pro His Pro His Pro His Pro Pro Gln His Ala Gln Tyr Val Gly 
            20                  25                  30          


Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu Val 
        35                  40                  45              


Lys Leu Gly Val His Cys Ile Thr Gly Gln Lys Val Ala Ile Lys Ile 
    50                  55                  60                  


Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg 
65                  70                  75                  80  


Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu 
                85                  90                  95      


His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His 
            100                 105                 110         


Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu 
        115                 120                 125             


Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala Leu 
    130                 135                 140                 


Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro Glu 
145                 150                 155                 160 


Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly 
                165                 170                 175     


Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys Gly 
            180                 185                 190         


Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr Asp 
        195                 200                 205             


Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala Leu 
    210                 215                 220                 


Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu 
225                 230                 235                 240 


Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro 
                245                 250                 255     


Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu Lys 
            260                 265                 270         


Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu Gly Gly 
        275                 280                 285             


Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg Val 
    290                 295                 300                 


Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu 
305                 310                 315                 320 


Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His 
                325                 330                 335     


Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp 
        355                 360                 365             


Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser 
    370                 375                 380                 


Pro Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met 
385                 390                 395                 400 


Glu Val Leu Ser Ile Thr Asp Ala Gly Gly Gly Gly Ser Pro Val Pro 
                405                 410                 415     


Thr Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser 
            420                 425                 430         


Val Ser Gly Ala Ser Thr Gly Leu Ser Ser Ser Pro Leu Ser Ser Pro 
        435                 440                 445             


Arg Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp Glu 
    450                 455                 460                 


Ala Arg Gly Gly Gly Ser Pro Thr Ser Lys Thr Gln Thr Leu Pro Ser 
465                 470                 475                 480 


Arg Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro Pro Ser 
                485                 490                 495     


Ala Arg Ser Thr Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser Ser 
            500                 505                 510         


Gly Gly Thr Pro Leu His Ser Pro Leu His Thr Pro Arg Ala Ser Pro 
        515                 520                 525             


Thr Gly Thr Pro Gly Thr Thr Pro Pro Pro Ser Pro Gly Gly Gly Val 
    530                 535                 540                 


Gly Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser Phe 
545                 550                 555                 560 


Leu Gly Ser Pro Arg Phe His Arg Arg Lys Met Gln Val Pro Thr Ala 
                565                 570                 575     


Glu Glu Met Ser Ser Leu Thr Pro Glu Ser Ser Pro Glu Leu Ala Lys 
            580                 585                 590         


Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln Ile 
        595                 600                 605             


Phe Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile 
    610                 615                 620                 


Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu Ser 
625                 630                 635                 640 


Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser Val 
                645                 650                 655     


Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu Gly 
            660                 665                 670         


Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile Tyr 
        675                 680                 685             


Ser Val Thr Phe Thr Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    690                 695                 700                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Gln Pro 
705                 710                 715                 720 


Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Thr Arg Pro 
                725                 730                 735     


Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro Asp 
            740                 745                 750         


Pro Glu Leu Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys Lys 
        755                 760                 765             


Leu Leu Ala Thr Asn Gly Thr Pro Leu Pro 
    770                 775             


<210>  81
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Pro Gln Ser Asn Asn Lys 
                325                 330                 335     


Asn Ser Leu Glu Pro Gln Thr Thr Val Val His Asn Ala Thr Asp Gly 
            340                 345                 350         


Ile Lys Gly Ser Thr Glu Ser Cys Asn Thr Thr Thr Glu Asp Glu Asp 
        355                 360                 365             


Leu Lys Val Arg Lys Gln Glu Ile Ile Lys Ile Thr Glu Gln Leu Ile 
    370                 375                 380                 


Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Thr Lys Ile Cys Asp 
385                 390                 395                 400 


Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu 
                405                 410                 415     


Gly Met Asp Phe His Lys Phe Tyr Phe Glu Asn Leu Leu Ser Lys Asn 
            420                 425                 430         


Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile 
        435                 440                 445             


Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile 
    450                 455                 460                 


Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val 
465                 470                 475                 480 


Trp His Arg Arg Asp Gly Lys Trp Leu Asn Val His Tyr His Cys Ser 
                485                 490                 495     


Gly Ala Pro Ala Ala Pro Leu Gln 
            500                 


<210>  82
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  83
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Gly Ala Ala Ala Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe 
            20                  25                  30          


Phe Asn Ala Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn 
        115                 120                 125             


Pro Val Thr Pro Lys Pro Pro Tyr Tyr Asn Ile Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys Ala Phe Trp Val 
145                 150                 155                 160 


Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu Val Pro Thr Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Thr Ser Val Asp Val Asp Leu Trp Leu Ile Thr Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Glu Thr Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Thr Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Thr Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr Trp Gln Lys His 
        435                 440                 445             


Ala Gly Met Ala Met Leu Cys Glu Thr Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly Glu Arg Ile Thr 
465                 470                 475                 480 


Gln Met Gln Arg Leu Thr Asn Ile Ile Thr Thr Glu Asp Ile Val Thr 
                485                 490                 495     


Val Val Thr Met Val Thr Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210>  84
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Glu Ser Leu Val Phe Ala Arg Arg Ser Gly Pro Thr Pro Ser Ala 
1               5                   10                  15      


Ala Glu Leu Ala Arg Pro Leu Ala Glu Gly Leu Ile Lys Ser Pro Lys 
            20                  25                  30          


Pro Leu Met Lys Lys Gln Ala Val Lys Arg His His His Lys His Asn 
        35                  40                  45              


Leu Arg His Arg Tyr Glu Phe Leu Glu Thr Leu Gly Lys Gly Thr Tyr 
    50                  55                  60                  


Gly Lys Val Lys Lys Ala Arg Glu Ser Ser Gly Arg Leu Val Ala Ile 
65                  70                  75                  80  


Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp Leu Met His 
                85                  90                  95      


Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His Pro His Ile 
            100                 105                 110         


Ile Ala Ile His Glu Val Phe Glu Asn Ser Ser Lys Ile Val Ile Val 
        115                 120                 125             


Met Glu Tyr Ala Ser Arg Gly Asp Leu Tyr Asp Tyr Ile Ser Glu Arg 
    130                 135                 140                 


Gln Gln Leu Ser Glu Arg Glu Ala Arg His Phe Phe Arg Gln Ile Val 
145                 150                 155                 160 


Ser Ala Val His Tyr Cys His Gln Asn Arg Val Val His Arg Asp Leu 
                165                 170                 175     


Lys Leu Glu Asn Ile Leu Leu Asp Ala Asn Gly Asn Ile Lys Ile Ala 
            180                 185                 190         


Asp Phe Gly Leu Ser Asn Leu Tyr His Gln Gly Lys Phe Leu Gln Thr 
        195                 200                 205             


Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu Ile Val Asn Gly Lys 
    210                 215                 220                 


Pro Tyr Thr Gly Pro Glu Val Asp Ser Trp Ser Leu Gly Val Leu Leu 
225                 230                 235                 240 


Tyr Ile Leu Val His Gly Thr Met Pro Phe Asp Gly His Asp His Lys 
                245                 250                 255     


Ile Leu Val Lys Gln Ile Ser Asn Gly Ala Tyr Arg Glu Pro Pro Lys 
            260                 265                 270         


Pro Ser Asp Ala Cys Gly Leu Ile Arg Trp Leu Leu Met Val Asn Pro 
        275                 280                 285             


Thr Arg Arg Ala Thr Leu Glu Asp Val Ala Ser His Trp Trp Val Asn 
    290                 295                 300                 


Trp Gly Tyr Ala Thr Arg Val Gly Glu Gln Glu Ala Pro His Glu Gly 
305                 310                 315                 320 


Gly His Pro Gly Ser Asp Ser Ala Arg Ala Ser Met Ala Asp Trp Leu 
                325                 330                 335     


Arg Arg Ser Ser Arg Pro Leu Leu Glu Asn Gly Ala Lys Val Cys Ser 
            340                 345                 350         


Phe Phe Lys Gln His Ala Pro Gly Gly Gly Ser Thr Thr Pro Gly Leu 
        355                 360                 365             


Glu Arg Gln His Ser Leu Lys Lys Ser Arg Lys Glu Asn Asp Met Ala 
    370                 375                 380                 


Gln Ser Leu His Ser Asp Thr Ala Asp Asp Thr Ala His Arg Pro Gly 
385                 390                 395                 400 


Lys Ser Asn Leu Lys Leu Pro Lys Gly Ile Leu Lys Lys Lys Val Ser 
                405                 410                 415     


Ala Ser Ala Glu Gly Val Gln Glu Asp Pro Pro Glu Leu Ser Pro Ile 
            420                 425                 430         


Pro Ala Ser Pro Gly Gln Ala Ala Pro Leu Leu Pro Lys Lys Gly Ile 
        435                 440                 445             


Leu Lys Lys Pro Arg Gln Arg Glu Ser Gly Tyr Tyr Ser Ser Pro Glu 
    450                 455                 460                 


Pro Ser Glu Ser Gly Glu Leu Leu Asp Ala Gly Asp Val Phe Val Ser 
465                 470                 475                 480 


Gly Asp Pro Lys Glu Gln Lys Pro Pro Gln Ala Ser Gly Leu Leu Leu 
                485                 490                 495     


His Arg Lys Gly Ile Leu Lys Leu Asn Gly Lys Phe Ser Gln Thr Ala 
            500                 505                 510         


Leu Glu Leu Ala Ala Pro Thr Thr Phe Gly Ser Leu Asp Glu Leu Ala 
        515                 520                 525             


Pro Pro Arg Pro Leu Ala Arg Ala Ser Arg Pro Ser Gly Ala Val Ser 
    530                 535                 540                 


Glu Asp Ser Ile Leu Ser Ser Glu Ser Phe Asp Gln Leu Asp Leu Pro 
545                 550                 555                 560 


Glu Arg Leu Pro Glu Pro Pro Leu Arg Gly Cys Val Ser Val Asp Asn 
                565                 570                 575     


Leu Thr Gly Leu Glu Glu Pro Pro Ser Glu Gly Pro Gly Ser Cys Leu 
            580                 585                 590         


Arg Arg Trp Arg Gln Asp Pro Leu Gly Asp Ser Cys Phe Ser Leu Thr 
        595                 600                 605             


Asp Cys Gln Glu Val Thr Ala Thr Tyr Arg Gln Ala Leu Arg Val Cys 
    610                 615                 620                 


Ser Lys Leu Thr 
625             


<210>  85
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ser Ala Leu Ala Gly Glu Asp Val Trp Arg Cys Pro Gly Cys Gly 
1               5                   10                  15      


Asp His Ile Ala Pro Ser Gln Ile Trp Tyr Arg Thr Val Asn Glu Thr 
            20                  25                  30          


Trp His Gly Ser Cys Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr 
        35                  40                  45              


Asn Trp Tyr Tyr Glu Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr 
    50                  55                  60                  


Trp Gly Lys Phe Gly Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr 
65                  70                  75                  80  


Gly Pro Phe Met Val Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe 
                85                  90                  95      


Ala Cys Met Ser Cys Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala 
            100                 105                 110         


Leu Val Gln His Ala Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val 
        115                 120                 125             


Val Leu Ala Pro Met Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu 
    130                 135                 140                 


Gln Leu Pro Tyr Ser Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu 
145                 150                 155                 160 


Gly Arg Arg Gly Phe Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr 
                165                 170                 175     


Ala Thr Thr Val Gln Val Lys Glu Val Asn Arg Met His Ile Ser Pro 
            180                 185                 190         


Asn Asn Arg Asn Ala Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn 
        195                 200                 205             


Gly Thr Pro Val Arg Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile 
    210                 215                 220                 


Ser Gln Thr Ser Gln Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val 
225                 230                 235                 240 


Ser Gln Arg Leu Asp Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His 
                245                 250                 255     


Met Gln Asn Ala Gly His Pro His Ala Leu Ser Thr Leu Asp Thr Lys 
            260                 265                 270         


Glu Asn Leu Glu Gly Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn 
        275                 280                 285             


Ser Ile Ser Lys Ser Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu 
    290                 295                 300                 


Phe Ser Arg Asp Ile Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser 
305                 310                 315                 320 


Tyr Ser Gln Gln Ile Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val 
                325                 330                 335     


Leu Gly Lys Gly Phe Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala 
            340                 345                 350         


Thr Gly Lys Val Met Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu 
        355                 360                 365             


Thr Gln Lys Thr Phe Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp 
    370                 375                 380                 


His Pro Asn Val Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys 
385                 390                 395                 400 


Leu Asn Leu Leu Thr Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe 
                405                 410                 415     


Leu Arg Ser Met Asp Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala 
            420                 425                 430         


Lys Gly Ile Ala Ser Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile 
        435                 440                 445             


His Arg Asp Leu Asn Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr 
    450                 455                 460                 


Val Val Val Ala Asp Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Ala Pro Met Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg 
                485                 490                 495     


Lys Asn Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp 
            500                 505                 510         


Met Ala Pro Glu Met Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp 
        515                 520                 525             


Ile Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr 
    530                 535                 540                 


Ala Asp Pro Asp Cys Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val 
545                 550                 555                 560 


Lys Leu Phe Trp Glu Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe 
                565                 570                 575     


Phe Pro Leu Ala Ala Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro 
            580                 585                 590         


Ala Phe Ser Lys Leu Glu Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu 
        595                 600                 605             


Gly Glu Leu Gly Ile Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His 
    610                 615                 620                 


Thr Val Ser Met Gln Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
625                 630                 635             


<210>  86
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Ser Ala Ser Ser Gly Pro Ser Ser Ser Val Gly Phe Ser Ser 
1               5                   10                  15      


Phe Asp Pro Ala Val Pro Ser Cys Thr Leu Ser Ser Ala Ala Ser Gly 
            20                  25                  30          


Ile Lys Arg Pro Met Ala Ser Glu Val Leu Glu Ala Arg Gln Asp Ser 
        35                  40                  45              


Tyr Ile Ser Leu Val Pro Tyr Ala Ser Gly Met Pro Ile Lys Lys Ile 
    50                  55                  60                  


Gly His Arg Ser Val Asp Ser Ser Gly Glu Thr Thr Tyr Lys Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Ala Leu Lys Gly Ala Ile Gln Leu Gly Ile Thr His Thr 
                85                  90                  95      


Val Gly Ser Leu Ser Thr Lys Pro Glu Arg Asp Val Leu Met Gln Asp 
            100                 105                 110         


Phe Tyr Val Val Glu Ser Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu 
        115                 120                 125             


Thr Pro Ala His His Tyr Asn Asp Phe Arg Phe Lys Thr Tyr Ala Pro 
    130                 135                 140                 


Val Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp 
145                 150                 155                 160 


Tyr Leu Tyr Ser Leu Cys Ser Glu Pro Leu Ile Glu Leu Cys Ser Ser 
                165                 170                 175     


Gly Ala Ser Gly Ser Leu Phe Tyr Val Ser Ser Asp Asp Glu Phe Ile 
            180                 185                 190         


Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu 
        195                 200                 205             


Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro 
    210                 215                 220                 


Lys Phe Tyr Gly Leu Tyr Cys Val Gln Ala Gly Gly Lys Asn Ile Arg 
225                 230                 235                 240 


Ile Val Val Met Asn Asn Leu Leu Pro Arg Ser Val Lys Met His Ile 
                245                 250                 255     


Lys Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg Ala Ser Gln Lys 
            260                 265                 270         


Glu Arg Glu Lys Pro Leu Pro Thr Phe Lys Asp Leu Asp Phe Leu Gln 
        275                 280                 285             


Asp Ile Pro Asp Gly Leu Phe Leu Asp Ala Asp Met Tyr Asn Ala Leu 
    290                 295                 300                 


Cys Lys Thr Leu Gln Arg Asp Cys Leu Val Leu Gln Ser Phe Lys Ile 
305                 310                 315                 320 


Met Asp Tyr Ser Leu Leu Met Ser Ile His Asn Ile Asp His Ala Gln 
                325                 330                 335     


Arg Glu Pro Leu Ser Ser Glu Thr Gln Tyr Ser Val Asp Thr Arg Arg 
            340                 345                 350         


Pro Ala Pro Gln Lys Ala Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln 
        355                 360                 365             


Gly Glu Ala Arg Arg Gly Gly Thr Met Glu Thr Asp Asp His Met Gly 
    370                 375                 380                 


Gly Ile Pro Ala Arg Asn Ser Lys Gly Glu Arg Leu Leu Leu Tyr Ile 
385                 390                 395                 400 


Gly Ile Ile Asp Ile Leu Gln Ser Tyr Arg Phe Val Lys Lys Leu Glu 
                405                 410                 415     


His Ser Trp Lys Ala Leu Val His Asp Gly Asp Thr Val Ser Val His 
            420                 425                 430         


Arg Pro Gly Phe Tyr Ala Glu Arg Phe Gln Arg Phe Met Cys Asn Thr 
        435                 440                 445             


Val Phe Lys Lys Ile Pro Leu Lys Pro Ser Pro Ser Lys Lys Phe Arg 
    450                 455                 460                 


Ser Gly Ser Ser Phe Ser Arg Arg Ala Gly Ser Ser Gly Asn Ser Cys 
465                 470                 475                 480 


Ile Thr Tyr Gln Pro Ser Val Ser Gly Glu His Lys Ala Gln Val Thr 
                485                 490                 495     


Thr Lys Ala Glu Val Glu Pro Gly Val His Leu Gly Arg Pro Asp Val 
            500                 505                 510         


Leu Pro Gln Thr Pro Pro Leu Glu Glu Ile Ser Glu Gly Ser Pro Ile 
        515                 520                 525             


Pro Asp Pro Ser Phe Ser Pro Leu Val Gly Glu Thr Leu Gln Met Leu 
    530                 535                 540                 


Thr Thr Ser Thr Thr Leu Glu Lys Leu Glu Val Ala Glu Ser Glu Phe 
545                 550                 555                 560 


Thr His 
        


<210>  87
<211>  1430
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          


Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  


Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 
65                  70                  75                  80  


Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             


Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 


Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 
            260                 265                 270         


Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 
        275                 280                 285             


Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 
    290                 295                 300                 


Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 
305                 310                 315                 320 


Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 
                325                 330                 335     


Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 
            340                 345                 350         


Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 
        355                 360                 365             


Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 
    370                 375                 380                 


Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 
385                 390                 395                 400 


Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 
                405                 410                 415     


Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 
            420                 425                 430         


Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 
        435                 440                 445             


Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 
    450                 455                 460                 


Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 
465                 470                 475                 480 


Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 
                485                 490                 495     


Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 
            500                 505                 510         


Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 
        515                 520                 525             


Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 
    530                 535                 540                 


His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 
545                 550                 555                 560 


Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 
                565                 570                 575     


Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 
            580                 585                 590         


Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 
        595                 600                 605             


Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 
    610                 615                 620                 


Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 
625                 630                 635                 640 


Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 
                645                 650                 655     


His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 
            660                 665                 670         


Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 
        675                 680                 685             


Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 
    690                 695                 700                 


Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 
705                 710                 715                 720 


Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 
                725                 730                 735     


Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 
            740                 745                 750         


Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 
        755                 760                 765             


Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 
    770                 775                 780                 


His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 
785                 790                 795                 800 


Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 
                805                 810                 815     


Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 
            820                 825                 830         


Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 
        835                 840                 845             


Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 
    850                 855                 860                 


Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 
865                 870                 875                 880 


Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg 
                885                 890                 895     


Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys 
            900                 905                 910         


Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 
        915                 920                 925             


Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 
    930                 935                 940                 


Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 
945                 950                 955                 960 


Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp 
                965                 970                 975     


Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 
            980                 985                 990         


Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 
        995                 1000                 1005             


Arg Arg  Ile Ala Gln Gln Leu  His Ser Thr Gly Glu  Ile Asn Ile 
    1010                 1015                 1020             


Met Gln  Ser Glu Thr Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 
    1025                 1030                 1035             


Trp Leu  Cys Thr Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Thr 
    1040                 1045                 1050             


Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Thr  Val Glu Asp 
    1055                 1060                 1065             


Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 
    1070                 1075                 1080             


Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 
    1085                 1090                 1095             


Thr Met  Val Asp Val Pro Ala  Leu Ile Lys Thr Asp  Asn Leu His 
    1100                 1105                 1110             


Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 
    1115                 1120                 1125             


Val Arg  Ile Val Pro Val Glu  His Leu Thr Pro Phe  Pro Cys Gly 
    1130                 1135                 1140             


Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 
    1145                 1150                 1155             


Gln Ser  Thr Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 
    1160                 1165                 1170             


Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 
    1175                 1180                 1185             


Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Thr 
    1190                 1195                 1200             


Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Thr 
    1205                 1210                 1215             


Ile Glu  Asn Val Met Ala Thr  Thr Leu Pro Gly Leu  Leu Thr Val 
    1220                 1225                 1230             


Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 
    1235                 1240                 1245             


Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Thr Leu 
    1250                 1255                 1260             


Lys Glu  Thr Ser Leu Thr Asn  Thr Met Gly Gly Tyr  Lys Glu Ser 
    1265                 1270                 1275             


Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 
    1280                 1285                 1290             


Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 
    1295                 1300                 1305             


Thr Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 
    1310                 1315                 1320             


Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 
    1325                 1330                 1335             


Leu Val  Ala Lys Tyr Asn Thr  Ser Asn Gly Ala Pro  Lys Asp Phe 
    1340                 1345                 1350             


Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Thr Thr Tyr 
    1355                 1360                 1365             


Pro Glu  Ser Thr Val Gly Thr  Leu Met Ser Lys Leu  Arg Glu Leu 
    1370                 1375                 1380             


Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 
    1385                 1390                 1395             


Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 
    1400                 1405                 1410             


Ser Cys  Asn Ser Gly Thr Ser  Tyr Asn Ser Ile Ser  Ser Val Val 
    1415                 1420                 1425             


Ser Arg  
    1430 


<210>  88
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu 
1               5                   10                  15      


Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp 
            20                  25                  30          


Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn 
        35                  40                  45              


Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln 
    50                  55                  60                  


Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His 
                85                  90                  95      


Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly 
            100                 105                 110         


Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg 
        115                 120                 125             


Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu 
    130                 135                 140                 


Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn 
145                 150                 155                 160 


Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu 
                165                 170                 175     


Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His 
            180                 185                 190         


Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val 
        195                 200                 205             


Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro 
    210                 215                 220                 


Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser 
225                 230                 235                 240 


Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly 
                245                 250                 255     


Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly 
            260                 265                 270         


Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln 
        275                 280                 285             


Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln 
    290                 295                 300                 


Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu 
305                 310                 315                 320 


Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser 
                325                 330                 335     


Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys 
            340                 345                 350         


Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys 
        355                 360                 365             


Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu 
    370                 375                 380                 


Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp 
385                 390                 395                 400 


Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro 
                405                 410                 415     


Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly 
            420                 425                 430         


Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys 
        435                 440                 445             


Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr 
    450                 455                 460                 


Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn 
465                 470                 475                 480 


Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu 
                485                 490                 495     


Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His 
            500                 505                 510         


Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu 
        515                 520                 525             


Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn 
    530                 535                 540                 


Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro 
545                 550                 555                 560 


Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp 
                565                 570                 575     


Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met 
            580                 585                 590         


Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val 
        595                 600                 605             


Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln 
    610                 615                 620                 


Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys 
625                 630                 635                 640 


Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr 
                645                 650                 655     


Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe 
            660                 665                 670         


Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp 
        675                 680                 685             


Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile 
    690                 695                 700                 


Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro 
705                 710                 715                 720 


Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln 
                725                 730                 735     


Phe Gln Glu Glu Asp Phe Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln 
            740                 745                 750         


Gln Leu Trp Glu Ala Glu Lys Val Lys Met Arg Gln Ile Leu Asp Lys 
        755                 760                 765             


Gln Gln Lys Gln Met Val Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu 
    770                 775                 780                 


Lys Ser Leu Asp Pro Met Val Tyr Met Asn Asp Lys Ser Pro Leu Thr 
785                 790                 795                 800 


Pro Glu Lys Glu Val Gly Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys 
                805                 810                 815     


Pro Pro Arg Leu Gly Ala Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp 
            820                 825                 830         


Arg Thr Asp Asp Leu Val Tyr Leu Asn Val Met Glu Leu Val Arg Ala 
        835                 840                 845             


Val Leu Glu Leu Lys Asn Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr 
    850                 855                 860                 


Val Val Val Val Lys Asn Val Gly Leu Thr Leu Arg Lys Leu Ile Gly 
865                 870                 875                 880 


Ser Val Asp Asp Leu Leu Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu 
                885                 890                 895     


Ile Glu Gly Thr Gln Lys Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile 
            900                 905                 910         


Asn Lys Met Arg Leu Ala Gln Gln Asn Ala Val Thr Ser Leu Ser Glu 
        915                 920                 925             


Glu Cys Lys Arg Gln Met Leu Thr Ala Ser His Thr Leu Ala Val Asp 
    930                 935                 940                 


Ala Lys Asn Leu Leu Asp Ala Val Asp Gln Ala Lys Val Leu Ala Asn 
945                 950                 955                 960 


Leu Ala His Pro Pro Ala Glu 
                965         


