                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  Use of Enzymes Having Silicase Activity

<130>  11390.204-WO

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  247
<212>  PRT
<213>  Methanosarcina thermophila

<400>  1

Met Met Phe Asn Lys Gln Ile Phe Thr Ile Leu Ile Leu Ser Leu Ser 
1               5                   10                  15      


Leu Ala Leu Ala Gly Ser Gly Cys Ile Ser Glu Gly Ala Glu Asp Asn 
            20                  25                  30          


Val Ala Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn 
        35                  40                  45              


Pro Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro 
    50                  55                  60                  


Thr Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile 
65                  70                  75                  80  


Gly Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu 
                85                  90                  95      


Gly Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val 
            100                 105                 110         


Val Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu 
        115                 120                 125             


Asp Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly 
    130                 135                 140                 


Asn Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala 
145                 150                 155                 160 


Val Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser 
                165                 170                 175     


Lys Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly 
            180                 185                 190         


Val Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr 
        195                 200                 205             


Ser Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala 
    210                 215                 220                 


Tyr Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala 
225                 230                 235                 240 


Glu Gly Tyr Lys Glu Thr Ser 
                245         


<210>  2
<211>  236
<212>  PRT
<213>  Bacillus licheniformis

<400>  2

Met Lys Leu Ser Ser Lys Leu Ile Leu Gly Leu Thr Val Ser Ser Leu 
1               5                   10                  15      


Ala Gly Lys Phe Leu Glu Lys Leu Leu Ile Gln Asp Asn Val Ser Pro 
            20                  25                  30          


Asn Ile Thr Ala Ser Phe Asn Gln Glu Ala Asp Ile Pro Asp Ile Asp 
        35                  40                  45              


Ala Ser Ser Tyr Ile His His Phe Ala Ser Val Ile Gly Ser Val Val 
    50                  55                  60                  


Ile Gly Arg Asn Val Phe Ile Gly Pro Phe Ser Ser Ile Arg Gly Asp 
65                  70                  75                  80  


Val Gly Leu Lys Ile Phe Ile Ser His Asp Cys Asn Ile Gln Asp Gly 
                85                  90                  95      


Val Val Leu His Gly Leu Lys Asn Tyr Glu Tyr Asn Ser Pro Val Thr 
            100                 105                 110         


Glu His Ser Val Phe Lys Asp Arg Glu Ser Tyr Ser Ile Tyr Ile Gly 
        115                 120                 125             


Glu Lys Val Ser Leu Ala Pro Gln Cys Gln Ile Tyr Gly Pro Val Arg 
    130                 135                 140                 


Ile Asp Lys Asn Val Phe Val Gly Met Gln Ser Leu Val Phe Asp Ala 
145                 150                 155                 160 


Tyr Ile Gln Glu Asp Thr Val Ile Glu Pro Gly Ala Lys Ile Ile Gly 
                165                 170                 175     


Val Thr Ile Pro Pro Lys Arg Phe Val Ser Ala Gly Arg Val Ile Ser 
            180                 185                 190         


Asn Gln Glu Asp Ala Asn Arg Leu Pro Glu Ile Thr Asp Ser Tyr Pro 
        195                 200                 205             


Tyr His Asp Leu Asn Ser Lys Met Thr Ser Val Asn Leu Glu Leu Ala 
    210                 215                 220                 


Lys Gly Tyr Lys Lys Glu Glu Arg Gln Trp Lys Leu 
225                 230                 235     


<210>  3
<211>  205
<212>  PRT
<213>  Pelobacter carbinolicus

<400>  3

Met Ile Glu Lys Asn Val Val Thr Asp Phe Cys Ser Glu Ala Ser Glu 
1               5                   10                  15      


Pro Val Ile Asp Ala Ser Thr Tyr Val His Pro Leu Ala Ala Val Ile 
            20                  25                  30          


Gly Asn Val Ile Leu Gly Lys Asn Ile Met Val Ser Pro Thr Ala Val 
        35                  40                  45              


Val Arg Gly Asp Glu Gly Gln Pro Leu His Val Gly Asp Asp Ser Asn 
    50                  55                  60                  


Ile Gln Asp Gly Val Val Ile His Ala Leu Glu Thr Glu Met Asn Gly 
65                  70                  75                  80  


Lys Pro Val Ala Lys Asn Leu Tyr Gln Val Asp Gly Arg Ser Tyr Gly 
                85                  90                  95      


Ala Tyr Val Gly Cys Arg Val Ser Leu Ala His Gln Val Gln Ile His 
            100                 105                 110         


Gly Pro Ala Val Val Leu Asp Asp Thr Phe Val Gly Met Lys Ser Leu 
        115                 120                 125             


Val Phe Lys Ser Phe Val Gly Lys Gly Cys Val Ile Glu Pro Gly Ser 
    130                 135                 140                 


Ile Val Met Gly Val Thr Val Ala Asp Gly Arg Tyr Val Pro Ala Gly 
145                 150                 155                 160 


Ser Val Ile Arg Thr Gln Glu Asp Ala Asp Ala Leu Pro Glu Ile Gly 
                165                 170                 175     


Ala Asp Tyr Pro Phe Arg Ala Met Asn Pro Gly Val Val His Val Asn 
            180                 185                 190         


Thr Ala Leu Ala Lys Gly Tyr Met Val Lys Gln Gly Asn 
        195                 200                 205 


<210>  4
<211>  204
<212>  PRT
<213>  Syntrophus aciditrophicus

<400>  4

Met Ile Gly Lys Asn Val Leu Thr Asp Phe Ser Ala Arg Ala Ser Glu 
1               5                   10                  15      


Pro Val Ile Gly Ser Phe Thr Phe Val His Pro Leu Ala Ala Val Ile 
            20                  25                  30          


Gly Asn Val Ile Leu Gly Asp Asn Ile Met Val Ser Pro Gly Ala Ser 
        35                  40                  45              


Ile Arg Gly Asp Glu Gly Gln Pro Leu Tyr Val Gly Ser Asp Ser Asn 
    50                  55                  60                  


Val Gln Asp Gly Val Val Ile His Ala Leu Glu Thr Glu Leu Asp Gly 
65                  70                  75                  80  


Lys Pro Val Glu Lys Asn Leu Val Glu Val Asp Gly Lys Lys Tyr Ala 
                85                  90                  95      


Val Tyr Val Gly Asn Arg Val Ser Leu Ala His Gln Val Gln Val His 
            100                 105                 110         


Gly Pro Ala Val Ile Arg Asp Asp Thr Phe Val Gly Met Lys Ser Leu 
        115                 120                 125             


Val Phe Lys Ser Tyr Val Gly Ser Asn Cys Val Ile Glu Pro Gly Val 
    130                 135                 140                 


Leu Leu Met Gly Val Thr Val Ala Asp Gly Arg Tyr Val Pro Ala Gly 
145                 150                 155                 160 


Ser Val Val Lys Thr Gln Glu Gln Ala Asp Ala Leu Pro Val Ile Thr 
                165                 170                 175     


Asp Asp Tyr Pro Met Lys Glu Met Asn Lys Gly Val Leu His Val Asn 
            180                 185                 190         


Lys Ala Leu Ala Arg Gly Tyr Leu Ala Ala Gly Ser 
        195                 200                 


<210>  5
<211>  248
<212>  PRT
<213>  Methanosarcina barkeri

<400>  5

Met Arg Phe Asn Lys Gln Thr Phe Thr Ile Leu Ile Leu Ser Leu Ser 
1               5                   10                  15      


Leu Ala Leu Leu Gly Ser Gly Cys Ile Ser Glu Gly Glu Gly Ala Glu 
            20                  25                  30          


Gly Asn Val Thr Gln Gly Ile Thr Glu Ser Glu Phe Ser Asn Ile Arg 
        35                  40                  45              


Glu Asn Pro Val Thr Pro Trp Asn Pro Val Pro Val Ala Pro Val Ile 
    50                  55                  60                  


Asp Pro Thr Ala Phe Ile Asp Pro Gln Ala Ser Val Ile Gly Asn Val 
65                  70                  75                  80  


Thr Ile Gly Ala Ser Val Met Val Ser Pro Met Ala Ser Ile Arg Ser 
                85                  90                  95      


Asp Glu Gly Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp 
            100                 105                 110         


Gly Val Val Leu His Ala Leu Glu Thr Ile Asp Glu Glu Gly Glu Pro 
        115                 120                 125             


Val Glu Asn Asn Ile Val Glu Val Gly Gly Lys Lys Tyr Ala Val Tyr 
    130                 135                 140                 


Ile Gly Glu Asn Val Ser Leu Ala His Gln Ala Gln Val His Gly Pro 
145                 150                 155                 160 


Ala Ser Val Gly Asn Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe 
                165                 170                 175     


Lys Ser Lys Ile Gly Asn Asn Cys Val Leu Glu Pro Thr Ser Ala Ala 
            180                 185                 190         


Ile Gly Val Thr Val Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val 
        195                 200                 205             


Val Thr Ser Gln Ala Glu Ala Asp Asn Leu Ser Glu Ile Thr Asp Asp 
    210                 215                 220                 


Tyr Ala Tyr Lys His Thr Asn Glu Ala Val Val Tyr Val Asn Val His 
225                 230                 235                 240 


Leu Ala Glu Gly Tyr Asn Lys Ala 
                245             


<210>  6
<211>  247
<212>  PRT
<213>  Methanosarcina acetivorans

<400>  6

Met Lys Ile Asn Arg Ile Phe Leu Ala Leu Leu Phe Ser Leu Ala Leu 
1               5                   10                  15      


Thr Leu Ala Gly Ser Gly Cys Val Ser Gln Gly Glu Gly Ala Glu Asp 
            20                  25                  30          


Gly Glu Ser Ala Asp Thr Glu Val Glu Ser Glu Val Ser Asn Ile Arg 
        35                  40                  45              


Ala Asn Pro Val Thr Pro Trp Asn Pro Glu Pro Thr Glu Pro Val Ile 
    50                  55                  60                  


Asp Ser Thr Ala Tyr Ile His Pro Gln Ala Ala Val Ile Gly Asp Val 
65                  70                  75                  80  


Thr Ile Gly Ala Ser Val Met Val Ser Pro Met Ala Ser Val Arg Ser 
                85                  90                  95      


Asp Glu Gly Thr Pro Ile Phe Val Gly Asp Glu Thr Asn Ile Gln Asp 
            100                 105                 110         


Gly Val Val Leu His Ala Leu Glu Thr Val Asn Glu Glu Gly Glu Pro 
        115                 120                 125             


Val Glu Ser Asn Leu Val Glu Val Asp Gly Glu Lys Tyr Ala Val Tyr 
    130                 135                 140                 


Val Gly Glu Arg Val Ser Leu Ala His Gln Ser Gln Ile His Gly Pro 
145                 150                 155                 160 


Ala Tyr Val Gly Asn Asp Thr Phe Ile Gly Met Gln Ala Leu Val Phe 
                165                 170                 175     


Lys Ala Asn Val Gly Asp Asn Cys Val Leu Glu Pro Lys Ser Gly Ala 
            180                 185                 190         


Ile Gly Val Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Thr Val 
        195                 200                 205             


Val Thr Ser Gln Ala Glu Ala Asp Glu Leu Pro Glu Val Thr Asp Asp 
    210                 215                 220                 


Tyr Gly Tyr Lys His Thr Asn Glu Ala Val Val Tyr Val Asn Val Asn 
225                 230                 235                 240 


Leu Ala Ala Gly Tyr Asn Ala 
                245         


<210>  7
<211>  243
<212>  PRT
<213>  Methanosarcina mazei

<400>  7

Met Ala Leu Leu Leu Ser Leu Ala Ile Thr Leu Ala Gly Ser Gly Cys 
1               5                   10                  15      


Val Ser Gln Gly Glu Gly Ala Glu Glu Gly Glu Asn Ile Glu Ala Glu 
            20                  25                  30          


Glu Val Glu Ala Asn Val Glu Glu Ser Asn Ile Arg Ala Asn Pro Val 
        35                  40                  45              


Thr Pro Trp Asn Pro Glu Pro Thr Glu Pro Val Ile Asp Pro Thr Ala 
    50                  55                  60                  


Tyr Ile His Pro Gln Ala Ser Val Ile Gly Asp Val Thr Ile Gly Ala 
65                  70                  75                  80  


Ser Val Met Val Ser Pro Met Ala Ser Val Arg Ser Asp Glu Gly Met 
                85                  90                  95      


Pro Ile Phe Val Gly Asp Glu Cys Asn Ile Gln Asp Gly Val Ile Leu 
            100                 105                 110         


His Ala Leu Glu Thr Val Asn Glu Glu Gly Glu Pro Val Glu Glu Asn 
        115                 120                 125             


Gln Val Glu Val Asp Gly Lys Lys Tyr Ala Val Tyr Ile Gly Glu Arg 
    130                 135                 140                 


Val Ser Leu Ala His Gln Ala Gln Val His Gly Pro Ser Leu Val Gly 
145                 150                 155                 160 


Asn Asp Thr Phe Ile Gly Met Gln Thr Phe Val Phe Lys Ala Lys Ile 
                165                 170                 175     


Gly Asn Asn Cys Val Leu Glu Pro Thr Ser Ala Ala Ile Gly Val Thr 
            180                 185                 190         


Val Pro Asp Gly Arg Tyr Ile Pro Ala Gly Thr Val Val Thr Ser Gln 
        195                 200                 205             


Asp Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Lys 
    210                 215                 220                 


His Thr Asn Glu Ala Val Val Tyr Val Asn Thr Asn Leu Ala Glu Gly 
225                 230                 235                 240 


Tyr Asn Ala 
            


<210>  8
<211>  275
<212>  PRT
<213>  Bacillus halodurans

<400>  8

Met Lys Lys Tyr Leu Trp Gly Lys Thr Cys Leu Val Val Ser Leu Ser 
1               5                   10                  15      


Val Met Val Thr Ala Cys Ser Ser Ala Pro Ser Thr Glu Pro Val Asp 
            20                  25                  30          


Glu Pro Ser Glu Thr His Glu Glu Thr Ser Gly Gly Ala His Glu Val 
        35                  40                  45              


His Trp Ser Tyr Thr Gly Asp Thr Gly Pro Glu His Trp Ala Glu Leu 
    50                  55                  60                  


Asp Ser Glu Tyr Gly Ala Cys Ala Gln Gly Glu Glu Gln Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Asp Lys Ala Glu Ala Val Asp Thr Asp Thr Glu Ile Gln Val 
                85                  90                  95      


His Tyr Glu Pro Ser Ala Phe Thr Ile Lys Asn Asn Gly His Thr Ile 
            100                 105                 110         


Gln Ala Glu Thr Thr Ser Asp Gly Asn Thr Ile Glu Ile Asp Gly Lys 
        115                 120                 125             


Glu Tyr Thr Leu Val Gln Phe His Phe His Ile Pro Ser Glu His Glu 
    130                 135                 140                 


Met Glu Gly Lys Asn Leu Asp Met Glu Leu His Phe Val His Lys Asn 
145                 150                 155                 160 


Glu Asn Asp Glu Leu Ala Val Leu Gly Val Leu Met Lys Ala Gly Glu 
                165                 170                 175     


Glu Asn Glu Glu Leu Ala Lys Leu Trp Ser Lys Leu Pro Ala Glu Glu 
            180                 185                 190         


Thr Glu Glu Asn Ile Ser Leu Asp Glu Ser Ile Asp Leu Asn Ala Leu 
        195                 200                 205             


Leu Pro Glu Ser Lys Glu Gly Phe His Tyr Asn Gly Ser Leu Thr Thr 
    210                 215                 220                 


Pro Pro Cys Ser Glu Gly Val Lys Trp Thr Val Leu Ser Glu Pro Ile 
225                 230                 235                 240 


Thr Val Ser Gln Glu Gln Ile Asp Ala Phe Ala Glu Ile Phe Pro Asp 
                245                 250                 255     


Asn His Arg Pro Val Gln Pro Trp Asn Asp Arg Asp Val Tyr Asp Val 
            260                 265                 270         


Ile Thr Glu 
        275 


<210>  9
<211>  263
<212>  PRT
<213>  Bacillus clausii

<400>  9

Met Lys Arg Ser His Leu Phe Thr Ser Ile Thr Leu Ala Ser Val Val 
1               5                   10                  15      


Thr Leu Ala Thr Ala Pro Ala Ala Ser Ala Ala Ser Phe Leu Ser Pro 
            20                  25                  30          


Leu Gln Ala Leu Lys Ala Ser Trp Ser Tyr Glu Gly Glu Thr Gly Pro 
        35                  40                  45              


Glu Phe Trp Gly Asp Leu Asp Glu Ala Phe Ala Ala Cys Ser Asn Gly 
    50                  55                  60                  


Lys Glu Gln Ser Pro Ile Asn Leu Phe Tyr Asp Arg Glu Gln Thr Ser 
65                  70                  75                  80  


Lys Trp Asn Trp Ala Phe Ser Tyr Ser Glu Ala Ala Phe Ser Val Glu 
                85                  90                  95      


Asn Asn Gly His Thr Ile Gln Ala Asn Val Glu Asn Glu Asp Ala Gly 
            100                 105                 110         


Gly Leu Glu Ile Asn Gly Glu Ala Tyr Gln Leu Ile Gln Phe His Phe 
        115                 120                 125             


His Thr Pro Ser Glu His Thr Ile Glu Glu Thr Ser Phe Pro Met Glu 
    130                 135                 140                 


Leu His Leu Val His Ala Asn His Ala Gly Asp Leu Ala Val Leu Gly 
145                 150                 155                 160 


Val Leu Met Glu Met Gly Asn Asp His Glu Gly Ile Glu Ala Val Trp 
                165                 170                 175     


Glu Val Met Pro Glu Glu Glu Gly Thr Ala Ala Tyr Ser Ile Ser Leu 
            180                 185                 190         


Asp Pro Asn Leu Phe Leu Pro Glu Ser Val Thr Ala Tyr Gln Tyr Asp 
        195                 200                 205             


Gly Ser Leu Thr Thr Pro Pro Cys Ser Glu Gly Val Lys Trp Thr Val 
    210                 215                 220                 


Leu Asn Asp Thr Ile Ser Ile Ser Glu Thr Gln Leu Asp Ala Phe Arg 
225                 230                 235                 240 


Asp Ile Tyr Pro Gln Asn Tyr Arg Pro Val Gln Glu Leu Gly Asp Arg 
                245                 250                 255     


Glu Ile Gly Phe His Tyr His 
            260             


<210>  10
<211>  240
<212>  PRT
<213>  Bacillus clausii

<400>  10

Ala Ser Ala Ala Ser Phe Leu Ser Pro Leu Gln Ala Leu Lys Ala Ser 
1               5                   10                  15      


Trp Ser Tyr Glu Gly Asp Thr Gly Pro Glu Phe Trp Gly Asp Leu Asp 
            20                  25                  30          


Glu Ala Phe Ala Ala Cys Ser Asn Gly Lys Glu Gln Ser Pro Ile Asn 
        35                  40                  45              


Leu Phe Tyr Asp Arg Glu Gln Thr Pro Lys Trp Asn Trp Ala Phe Ser 
    50                  55                  60                  


Tyr Ser Glu Ala Ala Phe Ser Val Glu Asn Asn Gly His Thr Ile Gln 
65                  70                  75                  80  


Ala Asn Val Glu Asn Glu Asp Ala Gly Gly Leu Glu Ile Asn Gly Glu 
                85                  90                  95      


Ala Tyr Gln Leu Thr Gln Phe His Phe His Thr Pro Ser Glu His Thr 
            100                 105                 110         


Ile Glu Glu Thr Ser Phe Pro Met Glu Leu His Leu Val His Ala Asn 
        115                 120                 125             


His Ala Gly Asp Leu Ala Val Leu Gly Val Leu Met Glu Ile Gly Asn 
    130                 135                 140                 


Asp His Glu Gly Ile Glu Ala Val Trp Glu Val Met Pro Glu Glu Glu 
145                 150                 155                 160 


Gly Thr Ala Glu Tyr Ser Ile Ser Ile Asp Pro Ser Leu Phe Leu Pro 
                165                 170                 175     


Glu Ser Val Thr Ala Tyr Gln Tyr Asp Gly Ser Leu Thr Thr Pro Pro 
            180                 185                 190         


Cys Ser Glu Gly Val Lys Trp Thr Val Leu Asn Asp Thr Ile Ser Ile 
        195                 200                 205             


Ser Ala Thr Gln Leu Asp Ala Phe Arg Ala Ile Tyr Pro Gln Asn Tyr 
    210                 215                 220                 


Arg Pro Val Gln Glu Leu Gly Asp Arg Glu Ile Gly Phe His Tyr His 
225                 230                 235                 240 


<210>  11
<211>  234
<212>  PRT
<213>  Bacillus plakortidis

<400>  11

Met Ser Lys Met Lys Thr Leu Arg Lys Leu Ser Leu Tyr Ala Ala Phe 
1               5                   10                  15      


Thr Leu Ser Ser Ser Ser Met Val Thr Ala Pro Leu Phe Ala Gln Thr 
            20                  25                  30          


Asp Thr His Gln Pro Leu Ile Pro Tyr His Ser Leu His Leu Leu Leu 
        35                  40                  45              


His Ser Asn Glu Lys Glu Gly Trp Ser Tyr Ser Gly Ser Thr Gly Pro 
    50                  55                  60                  


Gln Phe Trp Ala Asp Leu His Asp Glu Tyr Ile Ala Cys Ser Gln Gly 
65                  70                  75                  80  


Lys Glu Gln Ser Pro Val Ala Leu His Asn Glu Asp Ala Ser Asp Glu 
                85                  90                  95      


Gly Lys Trp Ser Leu Asp Leu Asp Tyr Asn Glu Thr Asp Phe Ser Ile 
            100                 105                 110         


Glu Asn Asn Gly His Thr Ile Gln Ala Asn Val Gly Asp His Ser Ser 
        115                 120                 125             


Asn Lys Leu Ile Val Asn Gly Thr Asp Tyr Lys Leu Ala Gln Phe His 
    130                 135                 140                 


Phe His Ser Gln Ser Glu His Thr Leu Asp Asp Asp Tyr Tyr Glu Met 
145                 150                 155                 160 


Glu Leu His Leu Val His Gln Asp Glu Glu Asp Asn Leu Ala Val Leu 
                165                 170                 175     


Gly Val Leu Ile Glu Glu Gly Glu Lys Asn Glu Thr Leu Ala Asn Met 
            180                 185                 190         


Trp Asp Val Ile Pro Glu Thr Glu Gly Glu Ala Asp Glu Thr Ile Ser 
        195                 200                 205             


Leu Asn Pro Ser Glu Leu Val Pro Lys Asp Pro Leu Val Ser Thr Cys 
    210                 215                 220                 


Arg Arg Ala Ser Ser Ser Phe Cys Ser Leu 
225                 230                 


<210>  12
<211>  276
<212>  PRT
<213>  Bacillus plakortidis

<400>  12

Met Arg Lys Thr Asn Val Leu Leu Lys Ser Thr Met Ile Thr Thr Leu 
1               5                   10                  15      


Leu Leu Ser Ser Thr Leu Leu Val Thr Thr Pro Ile Tyr Ala His Thr 
            20                  25                  30          


Glu Thr Gln Gln Leu Ser Tyr Lys Thr Leu Asn Asp Leu Leu Thr Glu 
        35                  40                  45              


Asp Gly His Ser Gly Trp Ser Tyr Ser Gly Leu Thr Gly Pro Glu Tyr 
    50                  55                  60                  


Trp Gly Glu Leu Asn Glu Asp Tyr Lys Ala Cys Ser Lys Gly Glu Glu 
65                  70                  75                  80  


Gln Ser Pro Ile Ala Leu Gln Asn Glu Asp Ile Asp Asn Glu Lys Trp 
                85                  90                  95      


Ser Phe Asp Leu Asp Tyr Glu Glu Thr Glu Phe Ser Ile Glu Asn Asn 
            100                 105                 110         


Gly His Thr Ile Gln Ala Asn Val Glu Gly Ser Ser Ser Asn Thr Leu 
        115                 120                 125             


Leu Leu Asn Asp Thr Glu Tyr Asn Leu Val Gln Phe His Phe His Ser 
    130                 135                 140                 


Pro Ser Glu His Thr Leu Asp Asp Glu Tyr Phe Glu Met Glu Val His 
145                 150                 155                 160 


Leu Val His Gln Asp Glu His Ala Asn Leu Ala Val Leu Gly Val Leu 
                165                 170                 175     


Ile Glu Glu Gly Glu Gln Asn Glu Thr Leu Thr Asp Met Trp Glu Leu 
            180                 185                 190         


Met Pro Gly Gln Gln Gly Glu Ala Ala Glu Arg Ile Thr Leu Asn Pro 
        195                 200                 205             


Ser Glu Leu Val Pro Ser Asp Leu Ser Thr Phe Gln Tyr Asp Gly Ser 
    210                 215                 220                 


Leu Thr Thr Pro Pro Cys Ser Glu Asp Val Lys Trp Ser Val Ser Asp 
225                 230                 235                 240 


Ser Thr Ile Ser Leu Ser Pro Glu Gln Leu Glu Ala Phe Gln Asp Leu 
                245                 250                 255     


Tyr Pro Asn Asn Tyr Arg Pro Ile Gln Asp Leu Gly Asn Arg Glu Val 
            260                 265                 270         


Gly Phe His Tyr 
        275     


