                         SEQUENCE LISTING

<110>  The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
       DAY, Regina M.
       OGNOON, Mungunsukh
       LEE, Young H.
 
<120>  Chimeric L. monocytogens In1B protein

<130>  044508-5026-WO

<150>  US 61/122,055
<151>  2008-12-12

<160>  14    

<170>  PatentIn version 3.4

<210>  1
<211>  286
<212>  PRT
<213>  Listeria monocytogenes

<400>  1

Glu Thr Ile Thr Val Ser Thr Pro Ile Lys Gln Ile Phe Pro Asp Asp 
1               5                   10                  15      


Ala Phe Ala Glu Thr Ile Lys Asp Asn Leu Lys Lys Lys Ser Val Thr 
            20                  25                  30          


Asp Ala Val Thr Gln Asn Glu Leu Asn Ser Ile Asp Gln Ile Ile Ala 
        35                  40                  45              


Asn Asn Ser Asp Ile Lys Ser Val Gln Gly Ile Gln Tyr Leu Pro Asn 
    50                  55                  60                  


Val Thr Lys Leu Phe Leu Asn Gly Asn Lys Leu Thr Asp Ile Lys Pro 
65                  70                  75                  80  


Leu Thr Asn Leu Lys Asn Leu Gly Trp Leu Phe Leu Asp Glu Asn Lys 
                85                  90                  95      


Ile Lys Asp Leu Ser Ser Leu Lys Asp Leu Lys Lys Leu Lys Ser Leu 
            100                 105                 110         


Ser Leu Glu His Asn Gly Ile Ser Asp Ile Asn Gly Leu Val His Leu 
        115                 120                 125             


Pro Gln Leu Glu Ser Leu Tyr Leu Gly Asn Asn Lys Ile Thr Asp Ile 
    130                 135                 140                 


Thr Val Leu Ser Arg Leu Thr Lys Leu Asp Thr Leu Ser Leu Glu Asp 
145                 150                 155                 160 


Asn Gln Ile Ser Asp Ile Val Pro Leu Ala Gly Leu Thr Lys Leu Gln 
                165                 170                 175     


Asn Leu Tyr Leu Ser Lys Asn His Ile Ser Asp Leu Arg Ala Leu Ala 
            180                 185                 190         


Gly Leu Lys Asn Leu Asp Val Leu Glu Leu Phe Ser Gln Glu Cys Leu 
        195                 200                 205             


Asn Lys Pro Ile Asn His Gln Ser Asn Leu Val Val Pro Asn Thr Val 
    210                 215                 220                 


Lys Asn Thr Asp Gly Ser Leu Val Thr Pro Glu Ile Ile Ser Asp Asp 
225                 230                 235                 240 


Gly Asp Tyr Glu Lys Pro Asn Val Lys Trp His Leu Pro Glu Phe Thr 
                245                 250                 255     


Asn Glu Val Ser Phe Ile Phe Tyr Gln Pro Val Thr Ile Gly Lys Ala 
            260                 265                 270         


Lys Ala Arg Phe His Gly Arg Val Thr Gln Pro Leu Lys Glu 
        275                 280                 285     


<210>  2
<211>  858
<212>  DNA
<213>  Listeria monocytogenes

<400>  2
gagactatca ccgtgtcaac gccaatcaag caaatttttc cagatgatgc ttttgcagaa     60

acaatcaaag acaatttaaa gaaaaaaagt gtgacagatg cagtgacaca aaatgaatta    120

aatagtatag atcaaatcat tgcgaataat agtgatatta aatccgttca aggaattcag    180

tatttaccca atgtgacaaa gttattttta aacgggaata aactaacaga tataaaaccc    240

ttaacaaact tgaaaaattt aggatggctt tttttagacg aaaataaaat taaagaccta    300

agttcgctca aggatctaaa aaaattaaaa tcactttctt tggagcataa tggtataagt    360

gatataaacg gacttgttca tttaccacag ctggaaagtt tgtatttggg aaataataaa    420

ataacggata taacggttct ttcacgttta actaaactgg atactttgtc tctcgaagat    480

aaccaaatta gtgatattgt gccacttgca ggtttaacta aattgcagaa cctatattta    540

agtaaaaatc acataagcga tttaagagca ttagcaggac ttaaaaatct agatgtttta    600

gaattattta gccaagaatg tcttaataag cctattaatc atcaatctaa tttggtcgtt    660

ccgaatacag tgaaaaacac tgatgggtcg ttagtgactc cagaaataat aagtgatgat    720

ggcgattatg aaaaacctaa tgttaaatgg catttaccag aatttacaaa tgaagtgagt    780

tttattttct atcagccagt cactattgga aaagcaaaag caagatttca tgggagagta    840

acccaaccac tgaaagag                                                  858


<210>  3
<211>  127
<212>  PRT
<213>  Human hepatocyte growth factor

<400>  3

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
        115                 120                 125         


<210>  4
<211>  381
<212>  DNA
<213>  Human hepatocyte growth factor

<400>  4
atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc     60

ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat    120

gaattcaaaa aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa    180

accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt    240

ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc    300

ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa    360

aacaaagact acattagaaa c                                              381


<210>  5
<211>  413
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic amino acid sequence of N-terminal hairpin loop of HGF 
       joined to amino acid sequence of InIB monomer

<400>  5

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Glu 
        115                 120                 125             


Thr Ile Thr Val Ser Thr Pro Ile Lys Gln Ile Phe Pro Asp Asp Ala 
    130                 135                 140                 


Phe Ala Glu Thr Ile Lys Asp Asn Leu Lys Lys Lys Ser Val Thr Asp 
145                 150                 155                 160 


Ala Val Thr Gln Asn Glu Leu Asn Ser Ile Asp Gln Ile Ile Ala Asn 
                165                 170                 175     


Asn Ser Asp Ile Lys Ser Val Gln Gly Ile Gln Tyr Leu Pro Asn Val 
            180                 185                 190         


Thr Lys Leu Phe Leu Asn Gly Asn Lys Leu Thr Asp Ile Lys Pro Leu 
        195                 200                 205             


Thr Asn Leu Lys Asn Leu Gly Trp Leu Phe Leu Asp Glu Asn Lys Ile 
    210                 215                 220                 


Lys Asp Leu Ser Ser Leu Lys Asp Leu Lys Lys Leu Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Glu His Asn Gly Ile Ser Asp Ile Asn Gly Leu Val His Leu Pro 
                245                 250                 255     


Gln Leu Glu Ser Leu Tyr Leu Gly Asn Asn Lys Ile Thr Asp Ile Thr 
            260                 265                 270         


Val Leu Ser Arg Leu Thr Lys Leu Asp Thr Leu Ser Leu Glu Asp Asn 
        275                 280                 285             


Gln Ile Ser Asp Ile Val Pro Leu Ala Gly Leu Thr Lys Leu Gln Asn 
    290                 295                 300                 


Leu Tyr Leu Ser Lys Asn His Ile Ser Asp Leu Arg Ala Leu Ala Gly 
305                 310                 315                 320 


Leu Lys Asn Leu Asp Val Leu Glu Leu Phe Ser Gln Glu Cys Leu Asn 
                325                 330                 335     


Lys Pro Ile Asn His Gln Ser Asn Leu Val Val Pro Asn Thr Val Lys 
            340                 345                 350         


Asn Thr Asp Gly Ser Leu Val Thr Pro Glu Ile Ile Ser Asp Asp Gly 
        355                 360                 365             


Asp Tyr Glu Lys Pro Asn Val Lys Trp His Leu Pro Glu Phe Thr Asn 
    370                 375                 380                 


Glu Val Ser Phe Ile Phe Tyr Gln Pro Val Thr Ile Gly Lys Ala Lys 
385                 390                 395                 400 


Ala Arg Phe His Gly Arg Val Thr Gln Pro Leu Lys Glu 
                405                 410             


<210>  6
<211>  1239
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic nucleotide sequence of N-terminal hairpin loop of HGF 
       joined to nucleotide sequence of InIB monomer

<400>  6
atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc     60

ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat    120

gaattcaaaa aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa    180

accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt    240

ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc    300

ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa    360

aacaaagact acattagaaa cgagactatc accgtgtcaa cgccaatcaa gcaaattttt    420

ccagatgatg cttttgcaga aacaatcaaa gacaatttaa agaaaaaaag tgtgacagat    480

gcagtgacac aaaatgaatt aaatagtata gatcaaatca ttgcgaataa tagtgatatt    540

aaatccgttc aaggaattca gtatttaccc aatgtgacaa agttattttt aaacgggaat    600

aaactaacag atataaaacc cttaacaaac ttgaaaaatt taggatggct ttttttagac    660

gaaaataaaa ttaaagacct aagttcgctc aaggatctaa aaaaattaaa atcactttct    720

ttggagcata atggtataag tgatataaac ggacttgttc atttaccaca gctggaaagt    780

ttgtatttgg gaaataataa aataacggat ataacggttc tttcacgttt aactaaactg    840

gatactttgt ctctcgaaga taaccaaatt agtgatattg tgccacttgc aggtttaact    900

aaattgcaga acctatattt aagtaaaaat cacataagcg atttaagagc attagcagga    960

cttaaaaatc tagatgtttt agaattattt agccaagaat gtcttaataa gcctattaat   1020

catcaatcta atttggtcgt tccgaataca gtgaaaaaca ctgatgggtc gttagtgact   1080

ccagaaataa taagtgatga tggcgattat gaaaaaccta atgttaaatg gcatttacca   1140

gaatttacaa atgaagtgag ttttattttc tatcagccag tcactattgg aaaagcaaaa   1200

gcaagatttc atgggagagt aacccaacca ctgaaagag                          1239


<210>  7
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic InIB dimer

<400>  7

Met His His His His His His Val Glu Thr Ile Thr Val Ser Thr Pro 
1               5                   10                  15      


Ile Lys Gln Ile Phe Pro Asp Asp Ala Phe Ala Glu Thr Ile Lys Asp 
            20                  25                  30          


Asn Leu Lys Lys Lys Ser Val Thr Asp Ala Val Thr Gln Asn Glu Leu 
        35                  40                  45              


Asn Ser Ile Asp Gln Ile Ile Ala Asn Asn Ser Asp Ile Lys Ser Val 
    50                  55                  60                  


Gln Gly Ile Gln Tyr Leu Pro Asn Val Thr Lys Leu Phe Leu Asn Gly 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ile Lys Pro Leu Thr Asn Leu Lys Asn Leu Gly 
                85                  90                  95      


Trp Leu Phe Leu Asp Glu Asn Lys Ile Lys Asp Leu Ser Ser Leu Lys 
            100                 105                 110         


Asp Leu Lys Lys Leu Lys Ser Leu Ser Leu Glu His Asn Gly Ile Ser 
        115                 120                 125             


Asp Ile Asn Gly Leu Val His Leu Pro Gln Leu Glu Ser Leu Tyr Leu 
    130                 135                 140                 


Gly Asn Asn Lys Ile Thr Asp Ile Thr Val Leu Ser Arg Leu Thr Lys 
145                 150                 155                 160 


Leu Asp Thr Leu Ser Leu Glu Asp Asn Gln Ile Ser Asp Ile Val Pro 
                165                 170                 175     


Leu Ala Gly Leu Thr Lys Leu Gln Asn Leu Tyr Leu Ser Lys Asn His 
            180                 185                 190         


Ile Ser Asp Leu Arg Ala Leu Ala Gly Leu Lys Asn Leu Asp Val Leu 
        195                 200                 205             


Glu Leu Phe Ser Gln Glu Cys Leu Asn Lys Pro Ile Asn His Gln Ser 
    210                 215                 220                 


Asn Leu Val Val Pro Asn Thr Val Lys Asn Thr Asp Gly Ser Leu Val 
225                 230                 235                 240 


Thr Pro Glu Ile Ile Ser Asp Asp Gly Asp Tyr Glu Lys Pro Asn Val 
                245                 250                 255     


Lys Trp His Leu Pro Glu Phe Thr Asn Glu Val Ser Phe Ile Phe Tyr 
            260                 265                 270         


Gln Pro Val Thr Ile Gly Lys Ala Lys Ala Arg Phe His Gly Arg Val 
        275                 280                 285             


Thr Gln Pro Leu Lys Glu Asn Val Glu Thr Ile Thr Val Ser Thr Pro 
    290                 295                 300                 


Ile Lys Gln Ile Phe Pro Asp Asp Ala Phe Ala Glu Thr Ile Lys Asp 
305                 310                 315                 320 


Asn Leu Lys Lys Lys Ser Val Thr Asp Ala Val Thr Gln Asn Glu Leu 
                325                 330                 335     


Asn Ser Ile Asp Gln Ile Ile Ala Asn Asn Ser Asp Ile Lys Ser Val 
            340                 345                 350         


Gln Gly Ile Gln Tyr Leu Pro Asn Val Thr Lys Leu Phe Leu Asn Gly 
        355                 360                 365             


Asn Lys Leu Thr Asp Ile Lys Pro Leu Thr Asn Leu Lys Asn Leu Gly 
    370                 375                 380                 


Trp Leu Phe Leu Asp Glu Asn Lys Ile Lys Asp Leu Ser Ser Leu Lys 
385                 390                 395                 400 


Asp Leu Lys Lys Leu Lys Ser Leu Ser Leu Glu His Asn Gly Ile Ser 
                405                 410                 415     


Asp Ile Asn Gly Leu Val His Leu Pro Gln Leu Glu Ser Leu Tyr Leu 
            420                 425                 430         


Gly Asn Asn Lys Ile Thr Asp Ile Thr Val Leu Ser Arg Leu Thr Lys 
        435                 440                 445             


Leu Asp Thr Leu Ser Leu Glu Asp Asn Gln Ile Ser Asp Ile Val Pro 
    450                 455                 460                 


Leu Ala Gly Leu Thr Lys Leu Gln Asn Leu Tyr Leu Ser Lys Asn His 
465                 470                 475                 480 


Ile Ser Asp Leu Arg Ala Leu Ala Gly Leu Lys Asn Leu Asp Val Leu 
                485                 490                 495     


Glu Leu Phe Ser Gln Glu Cys Leu Asn Lys Pro Ile Asn His Gln Ser 
            500                 505                 510         


Asn Leu Val Val Pro Asn Thr Val Lys Asn Thr Asp Gly Ser Leu Val 
        515                 520                 525             


Thr Pro Glu Ile Ile Ser Asp Asp Gly Asp Tyr Glu Lys Pro Asn Val 
    530                 535                 540                 


Lys Trp His Leu Pro Glu Phe Thr Asn Glu Val Ser Phe Ile Phe Tyr 
545                 550                 555                 560 


Gln Pro Val Thr Ile Gly Lys Ala Lys Ala Arg Phe His Gly Arg Val 
                565                 570                 575     


Thr Gln Pro Leu Lys Glu 
            580         


<210>  8
<211>  1758
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic InIB dimer

<400>  8
atgcatcatc atcatcatca cgtggagact atcaccgtgt caacgccaat caagcaaatt     60

tttccagatg atgcttttgc agaaacaatc aaagacaatt taaagaaaaa aagtgtgaca    120

gatgcagtga cacaaaatga attaaatagt atagatcaaa tcattgcgaa taatagtgat    180

attaaatccg ttcaaggaat tcagtattta cccaatgtga caaagttatt tttaaacggg    240

aataaactaa cagatataaa acccttaaca aacttgaaaa atttaggatg gcttttttta    300

gacgaaaata aaattaaaga cctaagttcg ctcaaggatc taaaaaaatt aaaatcactt    360

tctttggagc ataatggtat aagtgatata aacggacttg ttcatttacc acagctggaa    420

agtttgtatt tgggaaataa taaaataacg gatataacgg ttctttcacg tttaactaaa    480

ctggatactt tgtctctcga agataaccaa attagtgata ttgtgccact tgcaggttta    540

actaaattgc agaacctata tttaagtaaa aatcacataa gcgatttaag agcattagca    600

ggacttaaaa atctagatgt tttagaatta tttagccaag aatgtcttaa taagcctatt    660

aatcatcaat ctaatttggt cgttccgaat acagtgaaaa acactgatgg gtcgttagtg    720

actccagaaa taataagtga tgatggcgat tatgaaaaac ctaatgttaa atggcattta    780

ccagaattta caaatgaagt gagttttatt ttctatcagc cagtcactat tggaaaagca    840

aaagcaagat ttcatgggag agtaacccaa ccactgaaag agaacgttga gactatcacc    900

gtgtcaacgc caatcaagca aatttttcca gatgatgctt ttgcagaaac aatcaaagac    960

aatttaaaga aaaaaagtgt gacagatgca gtgacacaaa atgaattaaa tagtatagat   1020

caaatcattg cgaataatag tgatattaaa tccgttcaag gaattcagta tttacccaat   1080

gtgacaaagt tatttttaaa cgggaataaa ctaacagata taaaaccctt aacaaacttg   1140

aaaaatttag gatggctttt tttagacgaa aataaaatta aagacctaag ttcgctcaag   1200

gatctaaaaa aattaaaatc actttctttg gagcataatg gtataagtga tataaacgga   1260

cttgttcatt taccacagct ggaaagtttg tatttgggaa ataataaaat aacggatata   1320

acggttcttt cacgtttaac taaactggat actttgtctc tcgaagataa ccaaattagt   1380

gatattgtgc cacttgcagg tttaactaaa ttgcagaacc tatatttaag taaaaatcac   1440

ataagcgatt taagagcatt agcaggactt aaaaatctag atgttttaga attatttagc   1500

caagaatgtc ttaataagcc tattaatcat caatctaatt tggtcgttcc gaatacagtg   1560

aaaaacactg atgggtcgtt agtgactcca gaaataataa gtgatgatgg cgattatgaa   1620

aaacctaatg ttaaatggca tttaccagaa tttacaaatg aagtgagttt tattttctat   1680

cagccagtca ctattggaaa agcaaaagca agatttcatg ggagagtaac ccaaccactg   1740

aaagagtaat agggatcc                                                 1758


<210>  9
<211>  709
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic amino sequence of N-terminal hairpin loop of HGF joined
       to amino acid sequence of InIB dimer

<400>  9

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Met 
        115                 120                 125             


His His His His His His Val Glu Thr Ile Thr Val Ser Thr Pro Ile 
    130                 135                 140                 


Lys Gln Ile Phe Pro Asp Asp Ala Phe Ala Glu Thr Ile Lys Asp Asn 
145                 150                 155                 160 


Leu Lys Lys Lys Ser Val Thr Asp Ala Val Thr Gln Asn Glu Leu Asn 
                165                 170                 175     


Ser Ile Asp Gln Ile Ile Ala Asn Asn Ser Asp Ile Lys Ser Val Gln 
            180                 185                 190         


Gly Ile Gln Tyr Leu Pro Asn Val Thr Lys Leu Phe Leu Asn Gly Asn 
        195                 200                 205             


Lys Leu Thr Asp Ile Lys Pro Leu Thr Asn Leu Lys Asn Leu Gly Trp 
    210                 215                 220                 


Leu Phe Leu Asp Glu Asn Lys Ile Lys Asp Leu Ser Ser Leu Lys Asp 
225                 230                 235                 240 


Leu Lys Lys Leu Lys Ser Leu Ser Leu Glu His Asn Gly Ile Ser Asp 
                245                 250                 255     


Ile Asn Gly Leu Val His Leu Pro Gln Leu Glu Ser Leu Tyr Leu Gly 
            260                 265                 270         


Asn Asn Lys Ile Thr Asp Ile Thr Val Leu Ser Arg Leu Thr Lys Leu 
        275                 280                 285             


Asp Thr Leu Ser Leu Glu Asp Asn Gln Ile Ser Asp Ile Val Pro Leu 
    290                 295                 300                 


Ala Gly Leu Thr Lys Leu Gln Asn Leu Tyr Leu Ser Lys Asn His Ile 
305                 310                 315                 320 


Ser Asp Leu Arg Ala Leu Ala Gly Leu Lys Asn Leu Asp Val Leu Glu 
                325                 330                 335     


Leu Phe Ser Gln Glu Cys Leu Asn Lys Pro Ile Asn His Gln Ser Asn 
            340                 345                 350         


Leu Val Val Pro Asn Thr Val Lys Asn Thr Asp Gly Ser Leu Val Thr 
        355                 360                 365             


Pro Glu Ile Ile Ser Asp Asp Gly Asp Tyr Glu Lys Pro Asn Val Lys 
    370                 375                 380                 


Trp His Leu Pro Glu Phe Thr Asn Glu Val Ser Phe Ile Phe Tyr Gln 
385                 390                 395                 400 


Pro Val Thr Ile Gly Lys Ala Lys Ala Arg Phe His Gly Arg Val Thr 
                405                 410                 415     


Gln Pro Leu Lys Glu Asn Val Glu Thr Ile Thr Val Ser Thr Pro Ile 
            420                 425                 430         


Lys Gln Ile Phe Pro Asp Asp Ala Phe Ala Glu Thr Ile Lys Asp Asn 
        435                 440                 445             


Leu Lys Lys Lys Ser Val Thr Asp Ala Val Thr Gln Asn Glu Leu Asn 
    450                 455                 460                 


Ser Ile Asp Gln Ile Ile Ala Asn Asn Ser Asp Ile Lys Ser Val Gln 
465                 470                 475                 480 


Gly Ile Gln Tyr Leu Pro Asn Val Thr Lys Leu Phe Leu Asn Gly Asn 
                485                 490                 495     


Lys Leu Thr Asp Ile Lys Pro Leu Thr Asn Leu Lys Asn Leu Gly Trp 
            500                 505                 510         


Leu Phe Leu Asp Glu Asn Lys Ile Lys Asp Leu Ser Ser Leu Lys Asp 
        515                 520                 525             


Leu Lys Lys Leu Lys Ser Leu Ser Leu Glu His Asn Gly Ile Ser Asp 
    530                 535                 540                 


Ile Asn Gly Leu Val His Leu Pro Gln Leu Glu Ser Leu Tyr Leu Gly 
545                 550                 555                 560 


Asn Asn Lys Ile Thr Asp Ile Thr Val Leu Ser Arg Leu Thr Lys Leu 
                565                 570                 575     


Asp Thr Leu Ser Leu Glu Asp Asn Gln Ile Ser Asp Ile Val Pro Leu 
            580                 585                 590         


Ala Gly Leu Thr Lys Leu Gln Asn Leu Tyr Leu Ser Lys Asn His Ile 
        595                 600                 605             


Ser Asp Leu Arg Ala Leu Ala Gly Leu Lys Asn Leu Asp Val Leu Glu 
    610                 615                 620                 


Leu Phe Ser Gln Glu Cys Leu Asn Lys Pro Ile Asn His Gln Ser Asn 
625                 630                 635                 640 


Leu Val Val Pro Asn Thr Val Lys Asn Thr Asp Gly Ser Leu Val Thr 
                645                 650                 655     


Pro Glu Ile Ile Ser Asp Asp Gly Asp Tyr Glu Lys Pro Asn Val Lys 
            660                 665                 670         


Trp His Leu Pro Glu Phe Thr Asn Glu Val Ser Phe Ile Phe Tyr Gln 
        675                 680                 685             


Pro Val Thr Ile Gly Lys Ala Lys Ala Arg Phe His Gly Arg Val Thr 
    690                 695                 700                 


Gln Pro Leu Lys Glu 
705                 


<210>  10
<211>  2139
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic nucleotide sequence of N-terminal hairpin loop of HGF 
       joined to nucleotide sequence of InIB dimer

<400>  10
atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc     60

ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat    120

gaattcaaaa aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa    180

accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt    240

ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc    300

ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa    360

aacaaagact acattagaaa catgcatcat catcatcatc acgtggagac tatcaccgtg    420

tcaacgccaa tcaagcaaat ttttccagat gatgcttttg cagaaacaat caaagacaat    480

ttaaagaaaa aaagtgtgac agatgcagtg acacaaaatg aattaaatag tatagatcaa    540

atcattgcga ataatagtga tattaaatcc gttcaaggaa ttcagtattt acccaatgtg    600

acaaagttat ttttaaacgg gaataaacta acagatataa aacccttaac aaacttgaaa    660

aatttaggat ggcttttttt agacgaaaat aaaattaaag acctaagttc gctcaaggat    720

ctaaaaaaat taaaatcact ttctttggag cataatggta taagtgatat aaacggactt    780

gttcatttac cacagctgga aagtttgtat ttgggaaata ataaaataac ggatataacg    840

gttctttcac gtttaactaa actggatact ttgtctctcg aagataacca aattagtgat    900

attgtgccac ttgcaggttt aactaaattg cagaacctat atttaagtaa aaatcacata    960

agcgatttaa gagcattagc aggacttaaa aatctagatg ttttagaatt atttagccaa   1020

gaatgtctta ataagcctat taatcatcaa tctaatttgg tcgttccgaa tacagtgaaa   1080

aacactgatg ggtcgttagt gactccagaa ataataagtg atgatggcga ttatgaaaaa   1140

cctaatgtta aatggcattt accagaattt acaaatgaag tgagttttat tttctatcag   1200

ccagtcacta ttggaaaagc aaaagcaaga tttcatggga gagtaaccca accactgaaa   1260

gagaacgttg agactatcac cgtgtcaacg ccaatcaagc aaatttttcc agatgatgct   1320

tttgcagaaa caatcaaaga caatttaaag aaaaaaagtg tgacagatgc agtgacacaa   1380

aatgaattaa atagtataga tcaaatcatt gcgaataata gtgatattaa atccgttcaa   1440

ggaattcagt atttacccaa tgtgacaaag ttatttttaa acgggaataa actaacagat   1500

ataaaaccct taacaaactt gaaaaattta ggatggcttt ttttagacga aaataaaatt   1560

aaagacctaa gttcgctcaa ggatctaaaa aaattaaaat cactttcttt ggagcataat   1620

ggtataagtg atataaacgg acttgttcat ttaccacagc tggaaagttt gtatttggga   1680

aataataaaa taacggatat aacggttctt tcacgtttaa ctaaactgga tactttgtct   1740

ctcgaagata accaaattag tgatattgtg ccacttgcag gtttaactaa attgcagaac   1800

ctatatttaa gtaaaaatca cataagcgat ttaagagcat tagcaggact taaaaatcta   1860

gatgttttag aattatttag ccaagaatgt cttaataagc ctattaatca tcaatctaat   1920

ttggtcgttc cgaatacagt gaaaaacact gatgggtcgt tagtgactcc agaaataata   1980

agtgatgatg gcgattatga aaaacctaat gttaaatggc atttaccaga atttacaaat   2040

gaagtgagtt ttattttcta tcagccagtc actattggaa aagcaaaagc aagatttcat   2100

gggagagtaa cccaaccact gaaagagtaa tagggatcc                          2139


<210>  11
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  11
gggaacacgt ggagactatc accgtgtcaa c                                    31


<210>  12
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  12
cgggatccta ttactctttc agtggttggg ttact                                35


<210>  13
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  13
tttggatcca acgttctctt tcagtggttg ggttacttc                            39


<210>  14
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  14
tttggatcca acgttctctt tcagtggttg ggttacttc                            39


