                         SEQUENCE LISTING

<110>  Kraus, Jean-Louis
       Blin, Olivier
 
<120>  PPAR AGONIST COMPOSITIONS AND METHODS OF USE

<130>  [-]

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  477
<212>  PRT
<213>  homo sapiens

<400>  1

Met Thr Met Val Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly 
1               5                   10                  15      


Ile Ser Ser Val Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe 
            20                  25                  30          


Asp Ile Lys Pro Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro 
        35                  40                  45              


His Tyr Glu Asp Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp 
    50                  55                  60                  


Tyr Lys Tyr Asp Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val 
65                  70                  75                  80  


Glu Pro Ala Ser Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn 
                85                  90                  95      


Lys Pro His Glu Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg 
            100                 105                 110         


Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys 
        115                 120                 125             


Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile 
    130                 135                 140                 


Tyr Asp Arg Cys Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn 
145                 150                 155                 160 


Lys Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser 
                165                 170                 175     


His Asn Ala Ile Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys 
            180                 185                 190         


Leu Leu Ala Glu Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser 
        195                 200                 205             


Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys 
    210                 215                 220                 


Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys 
225                 230                 235                 240 


Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met 
                245                 250                 255     


Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu 
            260                 265                 270         


Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg 
        275                 280                 285             


Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro 
    290                 295                 300                 


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
305                 310                 315                 320 


Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys 
                325                 330                 335     


Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe 
            340                 345                 350         


Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe 
        355                 360                 365             


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
    370                 375                 380                 


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
385                 390                 395                 400 


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
                405                 410                 415     


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
            420                 425                 430         


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
        435                 440                 445             


His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser 
    450                 455                 460                 


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
465                 470                 475         


<210>  2
<211>  468
<212>  PRT
<213>  homo sapiens

<400>  2

Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala 
1               5                   10                  15      


Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly 
            20                  25                  30          


Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser 
        35                  40                  45              


Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp 
    50                  55                  60                  


Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly 
                85                  90                  95      


Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr 
            100                 105                 110         


His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg 
        115                 120                 125             


Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe His Lys 
145                 150                 155                 160 


Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met 
                165                 170                 175     


Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu 
            180                 185                 190         


His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys 
        195                 200                 205             


Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys 
    210                 215                 220                 


Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val 
225                 230                 235                 240 


Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala 
                245                 250                 255     


Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile 
            260                 265                 270         


Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr 
        275                 280                 285             


Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp 
    290                 295                 300                 


Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met 
305                 310                 315                 320 


Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn 
                325                 330                 335     


Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys 
            340                 345                 350         


Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu 
        355                 360                 365             


Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys 
    370                 375                 380                 


Cys Gly Asp Arg Pro Gly Leu Leu Asn Val Gly His Ile Glu Lys Met 
385                 390                 395                 400 


Gln Glu Gly Ile Val His Val Leu Arg Leu His Leu Gln Ser Asn His 
                405                 410                 415     


Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp 
            420                 425                 430         


Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val Gln Ile Ile Lys 
        435                 440                 445             


Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu Gln Glu Ile Tyr 
    450                 455                 460                 


Arg Asp Met Tyr 
465             


<210>  3
<211>  477
<212>  PRT
<213>  homo sapiens

<400>  3

Met Thr Met Val Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly 
1               5                   10                  15      


Ile Ser Ser Val Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe 
            20                  25                  30          


Asp Ile Lys Pro Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro 
        35                  40                  45              


His Tyr Glu Asp Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp 
    50                  55                  60                  


Tyr Lys Tyr Asp Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val 
65                  70                  75                  80  


Glu Pro Ala Ser Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn 
                85                  90                  95      


Lys Pro His Glu Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg 
            100                 105                 110         


Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys 
        115                 120                 125             


Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile 
    130                 135                 140                 


Tyr Asp Arg Cys Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn 
145                 150                 155                 160 


Lys Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser 
                165                 170                 175     


His Asn Ala Ile Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys 
            180                 185                 190         


Leu Leu Ala Glu Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser 
        195                 200                 205             


Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys 
    210                 215                 220                 


Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys 
225                 230                 235                 240 


Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met 
                245                 250                 255     


Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu 
            260                 265                 270         


Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg 
        275                 280                 285             


Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro 
    290                 295                 300                 


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
305                 310                 315                 320 


Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys 
                325                 330                 335     


Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe 
            340                 345                 350         


Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe 
        355                 360                 365             


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
    370                 375                 380                 


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
385                 390                 395                 400 


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
                405                 410                 415     


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
            420                 425                 430         


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
        435                 440                 445             


His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser 
    450                 455                 460                 


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
465                 470                 475         


<210>  4
<211>  462
<212>  PRT
<213>  homo sapiens

<400>  4

Met Asp Thr Lys His Phe Leu Pro Leu Asp Phe Ser Thr Gln Val Asn 
1               5                   10                  15      


Ser Ser Leu Thr Ser Pro Thr Gly Arg Gly Ser Met Ala Ala Pro Ser 
            20                  25                  30          


Leu His Pro Ser Leu Gly Pro Gly Ile Gly Ser Pro Gly Gln Leu His 
        35                  40                  45              


Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly Met Gly Pro Pro 
    50                  55                  60                  


Phe Ser Val Ile Ser Ser Pro Met Gly Pro His Ser Met Ser Val Pro 
65                  70                  75                  80  


Thr Thr Pro Thr Leu Gly Phe Ser Thr Gly Ser Pro Gln Leu Ser Ser 
                85                  90                  95      


Pro Met Asn Pro Val Ser Ser Ser Glu Asp Ile Lys Pro Pro Leu Gly 
            100                 105                 110         


Leu Asn Gly Val Leu Lys Val Pro Ala His Pro Ser Gly Asn Met Ala 
        115                 120                 125             


Ser Phe Thr Lys His Ile Cys Ala Ile Cys Gly Asp Arg Ser Ser Gly 
    130                 135                 140                 


Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys 
145                 150                 155                 160 


Arg Thr Val Arg Lys Asp Leu Thr Tyr Thr Cys Arg Asp Asn Lys Asp 
                165                 170                 175     


Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln Tyr Cys Arg Tyr 
            180                 185                 190         


Gln Lys Cys Leu Ala Met Gly Met Lys Arg Glu Ala Val Gln Glu Glu 
        195                 200                 205             


Arg Gln Arg Gly Lys Asp Arg Asn Glu Asn Glu Val Glu Ser Thr Ser 
    210                 215                 220                 


Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
                245                 250                 255     


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
            260                 265                 270         


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
        275                 280                 285             


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
    290                 295                 300                 


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
305                 310                 315                 320 


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
                325                 330                 335     


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
            340                 345                 350         


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
        355                 360                 365             


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
    370                 375                 380                 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
385                 390                 395                 400 


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
                405                 410                 415     


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
            420                 425                 430         


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
        435                 440                 445             


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
    450                 455                 460         


