                         SEQUENCE LISTING

<110>  Seattle Genetics, Inc.
       Sievers, Eric
       Kennedy, Dana
       Ihle, Nathan
       Sun, Michael
 
<120>  WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG 
       CONJUGATES

<130>  0030-00605PC

<150>  US 61/143,713
<151>  2009-01-09

<150>  US 61/152,205
<151>  2009-02-12

<150>  US 61/175,719
<151>  2009-05-05

<150>  US 61/264,222
<151>  2009-11-24

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(351)

<400>  1
cag atc cag ctg cag cag tct gga cct gag gtg gtg aag cct ggg gct         48
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ata tcc tgc aag gct tct ggc tac acc ttc act gac tac         96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

tat ata acc tgg gtg aag cag aag cct gga cag gga ctt gag tgg att        144
Tyr Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tgg att tat cct gga agc ggt aat act aag tac aat gag aag ttc        192
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag ggc aag gcc aca ttg act gta gac aca tcc tcc agc aca gcc ttc        240
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe           
65                  70                  75                  80            

atg cag ctc agc agc ctg aca tct gag gac act gct gtc tat ttc tgt        288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aac tat ggt aac tac tgg ttt gct tac tgg ggc caa ggg act cag        336
Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln           
            100                 105                 110                   

gtc act gtc tct gca                                                    351
Val Thr Val Ser Ala                                                       
        115                                                               


<210>  2
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  3
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  3
gactactata taacc                                                        15


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Tyr Tyr Ile Thr 
1               5   


<210>  5
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  5
tggatttatc ctggaagcgg taatactaag tacaatgaga agttcaaggg c                51


<210>  6
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  6

Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  7
tatggtaact actggtttgc ttac                                              24


<210>  8
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  8

Tyr Gly Asn Tyr Trp Phe Ala Tyr 
1               5               


<210>  9
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(333)

<400>  9
gac att gtg ctg acc caa tct cca gct tct ttg gct gtg tct cta ggg         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

cag agg gcc acc atc tcc tgc aag gcc agc caa agt gtt gat ttt gat         96
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp           
            20                  25                  30                    

ggt gat agt tat atg aac tgg tac caa cag aaa cca gga cag cca ccc        144
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro           
        35                  40                  45                        

aaa gtc ctc atc tat gct gca tcc aat cta gaa tct ggg atc cca gcc        192
Lys Val Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala           
    50                  55                  60                            

agg ttt agt ggc agt ggg tct ggg aca gac ttc acc ctc aac atc cat        240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His           
65                  70                  75                  80            

cct gtg gag gag gag gat gct gca acc tat tac tgt cag caa agt aat        288
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn           
                85                  90                  95                

gag gat ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa            333
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys               
            100                 105                 110                   


<210>  10
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  11
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  11
aaggccagcc aaagtgttga ttttgatggt gatagttata tgaac                       45


<210>  12
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  13
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  13
gctgcatcca atctagaatc t                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  15
cagcaaagta atgaggatcc gtggacg                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  17
<211>  375
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(375)

<400>  17
gag gtg aag ctg gtg gag tct gga gga ggc ttg gta cag cct ggg ggt         48
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct ctg aga ctc tcc tgt gca act tct ggg ttc acc ttc agt gat tac         96
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr           
            20                  25                  30                    

tat atg aac tgg gtc cgc cag cct cca gga aag gct ctt gag tgg ttg        144
Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu           
        35                  40                  45                        

ggt ttt att aga aac aaa gct aat ggt tac aca aca gag ttc agt gca        192
Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Phe Ser Ala           
    50                  55                  60                            

tct gtg atg ggt cgg ttc acc atc tcc aga gat gat tcc caa agc atc        240
Ser Val Met Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile           
65                  70                  75                  80            

ctc tat ctt cag atg aac acc ctg aga gct gag gac agt gcc act tat        288
Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr           
                85                  90                  95                

tac tgt gca aga gat ccc ccc tat ggt aac ccc cat tat tat gct atg        336
Tyr Cys Ala Arg Asp Pro Pro Tyr Gly Asn Pro His Tyr Tyr Ala Met           
            100                 105                 110                   

gac tac tgg ggt caa gga acc tca gtc acc gtc tcc tca                    375
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  18
<211>  125
<212>  PRT
<213>  Mus musculus

<400>  18

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Phe Ser Ala 
    50                  55                  60                  


Ser Val Met Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Pro Pro Tyr Gly Asn Pro His Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  19
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  19
gattactata tgaac                                                        15


<210>  20
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Tyr Tyr Met Asn 
1               5   


<210>  21
<211>  57
<212>  DNA
<213>  Mus musculus

<400>  21
tttattagaa acaaagctaa tggttacaca acagagttca gtgcatctgt gatgggt          57


<210>  22
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  22

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Phe Ser Ala Ser 
1               5                   10                  15      


Val Met Gly 
            


<210>  23
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  23
gatcccccct atggtaaccc ccattattat gctatggact ac                          42


<210>  24
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Pro Pro Tyr Gly Asn Pro His Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  25
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(333)

<400>  25
gac att gtg ctg acc cag tct cct gct tcc tta gct gtt tct ctg ggg         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

cag agg gcc acc atc tca tgc agg gcc agc aaa agt gtc agt gca tct         96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ala Ser           
            20                  25                  30                    

ggc tat aat tat atg cac tgg tac caa cag aaa gca ggg cag cca ccc        144
Gly Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro           
        35                  40                  45                        

aaa ctc ctc atc cat ctt gca tcc aac cta gaa tct ggg gtc cct gcc        192
Lys Leu Leu Ile His Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala           
    50                  55                  60                            

agg ttc agt ggc agt ggg tct ggg aca gac ttc acc ctc aac atc cat        240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His           
65                  70                  75                  80            

cct gtg gag gag gag gat gct tca acc tat tac tgt cag cac agt ggg        288
Pro Val Glu Glu Glu Asp Ala Ser Thr Tyr Tyr Cys Gln His Ser Gly           
                85                  90                  95                

gag ctt cca ttc acg ttc ggc tcg ggg aca aag ttg gaa ata aaa            333
Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys               
            100                 105                 110                   


<210>  26
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ala Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile His Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ser Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  27
agggccagca aaagtgtcag tgcatctggc tataattata tgcac                       45


<210>  28
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  28

Arg Ala Ser Lys Ser Val Ser Ala Ser Gly Tyr Asn Tyr Met His 
1               5                   10                  15  


<210>  29
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  29
cttgcatcca acctagaatc t                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  30

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  31
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  31
cagcacagtg gggagcttcc attcacg                                           27


<210>  32
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  32

Gln His Ser Gly Glu Leu Pro Phe Thr 
1               5                   


<210>  33
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  34
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  34

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


