                         SEQUENCE LISTING

<110> AMERICAN TYPE CULTURE COLLECTION
 
<120> COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF 
      TYPE 2 DIABETES

<130> 053178-065261-PCT

<140> 
<141> 

<150> 11/901,925
<151> 2007-09-18

<150> PCT/US2007/007875
<151> 2007-03-28

<150> 60/841,717
<151> 2006-09-01

<160> 28     

<170> PatentIn version 3.5

<210> 1
<211> 38
<212> PRT
<213> Rattus norvegicus

<400> 1
Ser Gly Arg Pro Pro Met Ile Val Trp Phe Asn Arg Pro Phe Leu Ile 
1               5                   10                  15      


Ala Val Ser His Thr His Gly Gln Thr Ile Leu Phe Met Ala Lys Val 
            20                  25                  30          


Ile Asn Pro Val Gly Ala 
        35              


<210> 2
<211> 85
<212> PRT
<213> Rattus norvegicus

<400> 2
Phe Ser Gln Gln Ala Asp Leu Ser Arg Ile Thr Gly Ala Lys Asp Leu 
1               5                   10                  15      


Ser Val Ser Gln Val Val His Lys Val Val Leu Asp Val Asn Glu Thr 
            20                  25                  30          


Gly Thr Glu Ala Ala Ala Ala Thr Gly Ala Asn Leu Val Pro Arg Ser 
        35                  40                  45              


Gly Arg Pro Pro Met Ile Val Trp Phe Asn Arg Pro Phe Leu Ile Ala 
    50                  55                  60                  


Val Ser His Thr His Gly Gln Thr Ile Leu Phe Met Ala Lys Val Ile 
65                  70                  75                  80  


Asn Pro Val Gly Ala 
                85  


<210> 3
<211> 419
<212> PRT
<213> Rattus norvegicus

<400> 3
Met Ala Phe Ile Ala Ala Leu Gly Leu Leu Met Ala Gly Ile Cys Pro 
1               5                   10                  15      


Ala Val Leu Gly Phe Pro Asp Gly Thr Leu Gly Asn Asp Thr Leu Leu 
            20                  25                  30          


His Lys Asp Gln Asp Lys Gly Thr Gln Leu Asp Ser Leu Thr Leu Glu 
        35                  40                  45              


Ser Ile Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Met Leu Ala Leu 
    50                  55                  60                  


Lys Asn Pro Asp Lys Asn Val Val Phe Ser Pro Leu Ser Ile Ser Ala 
65                  70                  75                  80  


Ala Leu Ala Ile Val Ser Leu Gly Ala Lys Gly Asn Thr Leu Glu Glu 
                85                  90                  95      


Ile Leu Glu Val Leu Arg Phe Asn Leu Thr Glu Ser Tyr Glu Thr Asp 
            100                 105                 110         


Ile His Gln Gly Phe Gly His Leu Leu Gln Arg Leu Ser Gln Pro Gly 
        115                 120                 125             


Asp Gln Val Lys Ile Ile Thr Gly Asn Ala Leu Phe Ile Asp Lys Asn 
    130                 135                 140                 


Leu Gln Val Leu Ala Glu Phe Gln Glu Lys Thr Arg Ala Leu Tyr Gln 
145                 150                 155                 160 


Val Glu Ala Phe Thr Ala Asp Phe Gln Gln Pro Arg Val Thr Glu Lys 
                165                 170                 175     


Leu Ile Asn Asp Tyr Val Arg Asn Gln Thr Gln Gly Lys Ile Gln Glu 
            180                 185                 190         


Leu Val Ser Gly Leu Lys Glu Arg Thr Ser Met Val Leu Val Asn Tyr 
        195                 200                 205             


Leu Leu Phe Arg Gly Lys Trp Lys Val Pro Phe Asp Pro Asp Tyr Thr 
    210                 215                 220                 


Phe Glu Ser Glu Phe Tyr Val Asp Glu Lys Arg Ser Val Lys Val Ser 
225                 230                 235                 240 


Met Met Lys Ile Glu Glu Leu Thr Thr Pro Tyr Phe Arg Asp Glu Glu 
                245                 250                 255     


Leu Ser Cys Ser Val Leu Glu Leu Lys Tyr Thr Gly Asn Ser Ser Ala 
            260                 265                 270         


Leu Phe Ile Leu Pro Asp Lys Gly Arg Met Gln Gln Val Glu Ala Ser 
        275                 280                 285             


Leu Gln Pro Glu Thr Leu Lys Lys Trp Lys Asp Ser Leu Arg Pro Arg 
    290                 295                 300                 


Lys Ile Asp Glu Leu Tyr Leu Pro Arg Leu Ser Ile Ser Thr Asp Tyr 
305                 310                 315                 320 


Ser Leu Glu Glu Val Leu Pro Glu Leu Gly Ile Arg Asp Val Phe Ser 
                325                 330                 335     


Gln Gln Ala Asp Leu Ser Arg Ile Thr Gly Ala Lys Asp Leu Ser Val 
            340                 345                 350         


Ser Gln Val Val His Lys Val Val Leu Asp Val Asn Glu Thr Gly Thr 
        355                 360                 365             


Glu Ala Ala Ala Ala Thr Gly Ala Asn Leu Val Pro Arg Ser Gly Arg 
    370                 375                 380                 

 
Pro Pro Met Ile Val Trp Phe Asn Arg Pro Phe Leu Ile Ala Val Ser 
385                 390                 395                 400 


His Thr His Gly Gln Thr Ile Leu Phe Met Ala Lys Val Ile Asn Pro 
                405                 410                 415     


Val Gly Ala 
            


<210> 4
<211> 17
<212> DNA
<213> Artificial

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 4
ttcaacmrrc cyttyst                                                      17


<210> 5
<211> 18
<212> DNA
<213> Artificial

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 5
yvacyttkcy makraaga                                                     18


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Phe Asn Arg Pro Phe Leu                                          
  1               5    


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<221> MOD_RES
<222> (3)..(3)
<223> Ser or Gly

<220> 
<221> MOD_RES
<222> (6)..(6)
<223> Thr or Val

<400> 7
Phe Met Xaa Lys Val Xaa Asn Pro                          
  1               5                  


<210> 8
<211> 32
<212> PRT
<213> Homo sapiens

<400> 8
Ile Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro Thr Asp  
  1               5                  10                  15    


Thr Gln Asn Ile Phe Phe Met Ser Lys Val Thr Asn Pro Lys Gln Ala  
             20                  25                  30        


<210> 9
<211> 31
<212> PRT
<213> Homo sapiens

<400> 9
Ile Val Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro Thr Asp Thr  
  1               5                  10                  15    


Gln Asn Ile Phe Phe Met Ser Lys Val Thr Asn Pro Lys Gln Ala      
             20                  25                  30    


<210> 10
<211> 31
<212> PRT
<213> Homo sapiens

<400> 10
Ile Val Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro Thr Asp Thr  
  1               5                  10                  15    


Gln Asn Ile Phe Phe Met Ser Lys Val Thr Asn Pro Lys Gln Ala      
             20                  25                  30    


<210> 11
<211> 32
<212> PRT
<213> Homo sapiens

<400> 11
Pro Pro Val Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn  
  1               5                  10                  15    


Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys  
             20                  25                  30        

                                                                
<210> 12
<211> 30
<212> PRT
<213> Homo sapiens

<400> 12
Ile Phe Asn Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln  
  1               5                  10                  15    


Ser Val Leu Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro          
             20                  25                  30


<210> 13
<211> 30
<212> PRT
<213> Homo sapiens

<400> 13
Ile Phe Asn Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln  
  1               5                  10                  15    


Ser Val Leu Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro          
             20                  25                  30


<210> 14
<211> 30
<212> PRT
<213> Homo sapiens

<400> 14
Pro Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys  
  1               5                  10                  15    


Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys          
             20                  25                  30


<210> 15
<211> 29
<212> PRT
<213> Homo sapiens

<400> 15
Phe Asn Arg Pro Phe Leu Val Ile Ile Lys Asp Asp Ile Thr Asn Phe  
  1               5                  10                  15    


Pro Leu Phe Ile Gly Lys Val Val Asn Pro Thr Gln Lys              
             20                  25                


<210> 16
<211> 29
<212> PRT
<213> Homo sapiens

<400> 16
Phe Asn Arg Pro Phe Leu Leu Leu Leu Trp Glu Val Thr Thr Gln Ser  
  1               5                  10                  15    


Leu Leu Phe Leu Gly Lys Val Val Asn Pro Val Ala Gly              
             20                  25                


<210> 17
<211> 29
<212> PRT
<213> Homo sapiens

<400> 17
Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro Leu Asn Thr  
  1               5                  10                  15    


Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys              
             20                  25                


<210> 18
<211> 133
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (23)..(118)

<400> 18
tgcattagtg gagacaagga cc att gtg cgt ttc aac agg ccc ttc ctg atg  52    
                         Ile Val Arg Phe Asn Arg Pro Phe Leu Met
                           1               5                  10

atc att gtc cct aca gac acc cag aac atc ttc ttc atg agc aaa gtc   100   
Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys Val
                 15                  20                  25    

acc aat ccc aag caa gcc tagagcttgc catca                          133   
Thr Asn Pro Lys Gln Ala                 
             30                         


<210> 19
<211> 133
<212> DNA
<213> Homo sapiens

<400> 19
tgcattagtg gagacaagga ccattgtgcg tttcaacagg cccttcctga tgatcattgt 60    

ccctacagac acccagaaca tcttcttcat gagcaaagtc accaatccca agcaagccta 120   

gagcttgcca tca                                                    133   


<210> 20
<211> 133
<212> DNA
<213> Homo sapiens

<400> 20
tgcattagtg gagacaagga ccattgtgcg tttcaacagg cccttcctga tgatcattgt 60    

ccctacagac acccagaaca tcttcttcat gagcaaagtc accaatccca agcaagccta 120   

gagcttgcca tca                                                    133   


<210> 21
<211> 98
<212> DNA
<213> Homo sapiens

<400> 21
ccccagaggt caagttcaac aaaccctttg tcttcttaat gattgaacaa aataccaagt 60    

ctcccctctt catgggaaaa gtggtgaatc ccacccaa                         98    


<210> 22
<211> 118
<212> DNA
<213> Homo sapiens

<400> 22
tgcccagacc aatcgccaca tcctgcgatt caaccggccc ttccttgtgg tgatcttttc 60    

caccagcacc cagagtgtcc tctttctggg caaggtcgtc gaccccacga aaccatag   118   


<210> 23
<211> 145
<212> DNA
<213> Homo sapiens

<400> 23
tgcccagacc aatcgccaca tcctgcgatt caaccggccc ttccttgtgg tgatcttttc 60    

caccagcacc cagagtgtcc tctttctggg caaggtcgtc gaccccacga aaccatagcc 120   

ctcccagggc tgctcatctg ttcca                                       145   


<210> 24
<211> 103
<212> DNA
<213> Homo sapiens

<400> 24
tatccccccc gaggtcaagt tcaacaaacc ctttgtcttc ttaatgattg aacaaaatac 60    

caagtctccc ctcttcatgg gaaaagtggt gaatcccacc caa                   103   


<210> 25
<211> 101
<212> DNA
<213> Homo sapiens

<400> 25
agtatcagac agtcatgttc aaccggccct tcctggtcat catcaaggat gacatcacca 60    

actttccgct cttcattgga aaagtggtga atcccaccca a                     101   


<210> 26
<211> 113
<212> DNA
<213> Homo sapiens

<400> 26
cccatctctg aacaccatgt cagacccaca tgcccacttc aacaggcctt tcctcttgct 60    

cctttgggag gtcaccaccc agagcttact cttcctggga aaagttgtca acc        113   


<210> 27
<211> 14
<212> PRT
<213> Rattus norvegicus

<400> 27
Ile Val Trp Phe Asn Arg Pro Phe Leu Ile Ala Val Ser His
1               5                   10                 


<210> 28
<211> 12
<212> PRT
<213> Rattus norvegicus

<400> 28
His Gly Gln Thr Ile Leu Phe Met Ala Lys Val Ile
1               5                   10          


