                         SEQUENCE LISTING

<110>  NsGene A/S
       Kusk, Philip
       Wahlberg, Lars Ulrik
 
<120>  Improved Cell Lines and their uses in Encapsulated Cell 
       Biodelivery

<130>  P2177PC00

<150>  US61/146,754
<151>  2009-01-23

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  412
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaagtgca gctgggtgat cttcttcctg atggcagtgg ttacaggtaa ggggctccca       60

agtcccaaac ttgagggtcc ataaactctg tgacagtggc aatcactttg cctttctttc      120

tacaggggtg aattcgggct ggaccctgaa cagcgcgggc tacctgctgg gccctcacgc      180

cgtgggcaac cacagaagct tcagcgacaa gaacggcctg accagcaagc gggagctgcg      240

gcccgaggac gacatgaagc ccggcagctt cgacagaagc atccccgaga acaacatcat      300

gcggaccatc atcgagtttc tgagctttct gcacctgaaa gaggccggag ccctggaccg      360

gctgctggat ctgcctgccg ctgcctcctc agaagacatc gagcggtcct ga              412


<210>  2
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro 
            20                  25                  30          


His Ala Val Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr 
        35                  40                  45              


Ser Lys Arg Glu Leu Arg Pro Glu Asp Asp Met Lys Pro Gly Ser Phe 
    50                  55                  60                  


Asp Arg Ser Ile Pro Glu Asn Asn Ile Met Arg Thr Ile Ile Glu Phe 
65                  70                  75                  80  


Leu Ser Phe Leu His Leu Lys Glu Ala Gly Ala Leu Asp Arg Leu Leu 
                85                  90                  95      


Asp Leu Pro Ala Ala Ala Ser Ser Glu Asp Ile Glu Arg Ser 
            100                 105                 110 


<210>  3
<211>  726
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(726)

<400>  3
atg tcc atg ttg ttc tac act ctg atc aca gct ttt ctg atc ggc ata         48
Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile           
1               5                   10                  15                

cag gcg gaa cca cac tca gag agc aat gtc cct gca gga cac acc atc         96
Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile           
            20                  25                  30                    

ccc caa gtc cac tgg act aaa ctt cag cat tcc ctt gac act gcc ctt        144
Pro Gln Val His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu           
        35                  40                  45                        

cgc aga gcc cgc agc gcc ccg gca gcg gcg ata gct gca cgc gtg gcg        192
Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala           
    50                  55                  60                            

ggg cag acc cgc aac att act gtg gac ccc agg ctg ttt aaa aag cgg        240
Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg           
65                  70                  75                  80            

cga ctc cgt tca ccc cgt gtg ctg ttt agc acc cag cct ccc cgt gaa        288
Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu           
                85                  90                  95                

gct gca gac act cag gat ctg gac ttc gag gtc ggt ggt gct gcc ccc        336
Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro           
            100                 105                 110                   

ttc aac agg act cac agg agc aag cgg tca tca tcc cat ccc atc ttc        384
Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe           
        115                 120                 125                       

cac agg ggc gaa ttc tcg gtg tgt gac agt gtc agc gtg tgg gtt ggg        432
His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly           
    130                 135                 140                           

gat aag acc acc gcc aca gac atc aag ggc aag gag gtg atg gtg ttg        480
Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu           
145                 150                 155                 160           

gga gag gtg aac att aac aac agt gta ttc aaa cag tac ttt ttt gag        528
Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu           
                165                 170                 175               

acc aag tgc cgg gac cca aat ccc gtt gac agc ggg tgc cgg ggc att        576
Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile           
            180                 185                 190                   

gac tca aag cac tgg aac tca tat tgt acc acg act cac acc ttt gtc        624
Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val           
        195                 200                 205                       

aag gcg ctg acc atg gat ggc aag cag gct gcc tgg cgg ttt atc cgg        672
Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg           
    210                 215                 220                           

ata gat acg gcc tgt gtg tgt gtg ctc agc agg aag gct gtg aga aga        720
Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val Arg Arg           
225                 230                 235                 240           

gcc tga                                                                726
Ala                                                                       
                                                                          


<210>  4
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile 
            20                  25                  30          


Pro Gln Val His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 
        35                  40                  45              


Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala 
    50                  55                  60                  


Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 
65                  70                  75                  80  


Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu 
                85                  90                  95      


Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro 
            100                 105                 110         


Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe 
        115                 120                 125             


His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly 
    130                 135                 140                 


Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu 
145                 150                 155                 160 


Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val 
        195                 200                 205             


Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg 
    210                 215                 220                 


Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val Arg Arg 
225                 230                 235                 240 


Ala 
    


<210>  5
<211>  227
<212>  DNA
<213>  Salmo salar

<400>  5
cagttgaagt cggaagttta catacactta agttggagtc attaaaactc gtttttcaac       60

tactccacaa atttcttgtt aacaaacaat agttttggca agtcagttag gacatctact      120

ttgtgcatga cacaagtcat ttttccaaca attgtttaca gacagattat ttcacttata      180

attcactgta tcacaattcc agtgggtcag aagtttacat acactaa                    227


<210>  6
<211>  228
<212>  DNA
<213>  Salmo salar

<400>  6
ttgagtgtat gtaaacttct gacccactgg gaatgtgatg aaagaaataa aagctgaaat       60

gaatcattct ctctactatt attctgatat ttcacattct taaaataaag tggtgatcct      120

aactgaccta agacagggaa tttttactag gattaaatgt caggaattgt gaaaaagtga      180

gtttaaatgt atttggctaa ggtgtatgta aacttccgac ttcaactg                   228


<210>  7
<211>  340
<212>  PRT
<213>  Salmo salar

<400>  7

Met Gly Lys Ser Lys Glu Ile Ser Gln Asp Leu Arg Lys Lys Ile Val 
1               5                   10                  15      


Asp Leu His Lys Ser Gly Ser Ser Leu Gly Ala Ile Ser Lys Arg Leu 
            20                  25                  30          


Lys Val Pro Arg Ser Ser Val Gln Thr Ile Val Arg Lys Tyr Lys His 
        35                  40                  45              


His Gly Thr Thr Gln Pro Ser Tyr Arg Ser Gly Arg Arg Arg Val Leu 
    50                  55                  60                  


Ser Pro Arg Asp Glu Arg Thr Leu Val Arg Lys Val Gln Ile Asn Pro 
65                  70                  75                  80  


Arg Thr Thr Ala Lys Asp Leu Val Lys Met Leu Glu Glu Thr Gly Thr 
                85                  90                  95      


Lys Val Ser Ile Ser Thr Val Lys Arg Val Leu Tyr Arg His Asn Leu 
            100                 105                 110         


Lys Gly Arg Ser Ala Arg Lys Lys Pro Leu Leu Gln Asn Arg His Lys 
        115                 120                 125             


Lys Ala Arg Leu Arg Phe Ala Thr Ala His Gly Asp Lys Asp Arg Thr 
    130                 135                 140                 


Phe Trp Arg Asn Val Leu Trp Ser Asp Glu Thr Lys Ile Glu Leu Phe 
145                 150                 155                 160 


Gly His Asn Asp His Arg Tyr Val Trp Arg Lys Lys Gly Glu Ala Cys 
                165                 170                 175     


Lys Pro Lys Asn Thr Ile Pro Thr Val Lys His Gly Gly Gly Ser Ile 
            180                 185                 190         


Met Leu Trp Gly Cys Phe Ala Ala Gly Gly Thr Gly Ala Leu His Lys 
        195                 200                 205             


Ile Asp Gly Ile Met Arg Lys Glu Asn Tyr Val Asp Ile Leu Lys Gln 
    210                 215                 220                 


His Leu Lys Thr Ser Val Arg Lys Leu Lys Leu Gly Arg Lys Trp Val 
225                 230                 235                 240 


Phe Gln Met Asp Asn Asp Pro Lys His Thr Ser Lys Val Val Ala Lys 
                245                 250                 255     


Trp Leu Lys Asp Asn Lys Val Lys Val Leu Glu Trp Pro Ser Gln Ser 
            260                 265                 270         


Pro Asp Leu Asn Pro Ile Glu Asn Leu Trp Ala Glu Leu Lys Lys Arg 
        275                 280                 285             


Val Arg Ala Arg Arg Pro Thr Asn Leu Thr Gln Leu His Gln Leu Cys 
    290                 295                 300                 


Gln Glu Glu Trp Ala Lys Ile His Pro Thr Tyr Cys Gly Lys Leu Val 
305                 310                 315                 320 


Glu Gly Tyr Pro Lys Arg Leu Thr Gln Val Lys Gln Phe Lys Gly Asn 
                325                 330                 335     


Ala Thr Lys Tyr 
            340 


<210>  8
<211>  340
<212>  PRT
<213>  Salmo salar

<400>  8

Met Gly Lys Ser Lys Glu Ile Ser Gln Asp Leu Arg Lys Arg Ile Val 
1               5                   10                  15      


Asp Leu His Lys Ser Gly Ser Ser Leu Gly Ala Ile Ser Lys Arg Leu 
            20                  25                  30          


Ala Val Pro Arg Ser Ser Val Gln Thr Ile Val Arg Lys Tyr Lys His 
        35                  40                  45              


His Gly Thr Thr Gln Pro Ser Tyr Arg Ser Gly Arg Arg Arg Val Leu 
    50                  55                  60                  


Ser Pro Arg Asp Glu Arg Thr Leu Val Arg Lys Val Gln Ile Asn Pro 
65                  70                  75                  80  


Arg Thr Thr Ala Lys Asp Leu Val Lys Met Leu Glu Glu Thr Gly Thr 
                85                  90                  95      


Lys Val Ser Ile Ser Thr Val Lys Arg Val Leu Tyr Arg His Asn Leu 
            100                 105                 110         


Lys Gly His Ser Ala Arg Lys Lys Pro Leu Leu Gln Asn Arg His Lys 
        115                 120                 125             


Lys Ala Arg Leu Arg Phe Ala Thr Ala His Gly Asp Lys Asp Arg Thr 
    130                 135                 140                 


Phe Trp Arg Asn Val Leu Trp Ser Asp Glu Thr Lys Ile Glu Leu Phe 
145                 150                 155                 160 


Gly His Asn Asp His Arg Tyr Val Trp Arg Lys Lys Gly Glu Ala Cys 
                165                 170                 175     


Lys Pro Lys Asn Thr Ile Pro Thr Val Lys His Gly Gly Gly Ser Ile 
            180                 185                 190         


Met Leu Trp Gly Cys Phe Ala Ala Gly Gly Thr Gly Ala Leu His Lys 
        195                 200                 205             


Ile Asp Gly Ile Met Asp Ala Val Gln Tyr Val Asp Ile Leu Lys Gln 
    210                 215                 220                 


His Leu Lys Thr Ser Val Arg Lys Leu Lys Leu Gly Arg Lys Trp Val 
225                 230                 235                 240 


Phe Gln His Asp Asn Asp Pro Lys His Thr Ser Lys Val Val Ala Lys 
                245                 250                 255     


Trp Leu Lys Asp Asn Lys Val Lys Val Leu Glu Trp Pro Ser Gln Ser 
            260                 265                 270         


Pro Asp Leu Asn Pro Ile Glu Asn Leu Trp Ala Glu Leu Lys Lys Arg 
        275                 280                 285             


Val Arg Ala Arg Arg Pro Thr Asn Leu Thr Gln Leu His Gln Leu Cys 
    290                 295                 300                 


Gln Glu Glu Trp Ala Lys Ile His Pro Asn Tyr Cys Gly Lys Leu Val 
305                 310                 315                 320 


Glu Gly Tyr Pro Lys Arg Leu Thr Gln Val Lys Gln Phe Lys Gly Asn 
                325                 330                 335     


Ala Thr Lys Tyr 
            340 


<210>  9
<211>  340
<212>  PRT
<213>  Salmo salar

<400>  9

Met Gly Lys Ser Lys Glu Ile Ser Gln Asp Leu Arg Lys Arg Ile Val 
1               5                   10                  15      


Asp Leu His Lys Ser Gly Ser Ser Leu Gly Ala Ile Ser Lys Arg Leu 
            20                  25                  30          


Ala Val Pro Arg Ser Ser Val Gln Thr Ile Val Arg Lys Tyr Lys His 
        35                  40                  45              


His Gly Thr Thr Gln Pro Ser Tyr Arg Ser Gly Arg Arg Arg Val Leu 
    50                  55                  60                  


Ser Pro Arg Asp Glu Arg Thr Leu Val Arg Lys Val Gln Ile Asn Pro 
65                  70                  75                  80  


Arg Thr Thr Ala Lys Asp Leu Val Lys Met Leu Glu Glu Thr Gly Thr 
                85                  90                  95      


Lys Val Ser Ile Ser Thr Val Lys Arg Val Leu Tyr Arg His Asn Leu 
            100                 105                 110         


Lys Gly His Ser Ala Arg Lys Lys Pro Leu Leu Gln Asn Arg His Lys 
        115                 120                 125             


Lys Ala Arg Leu Arg Phe Ala Thr Ala His Gly Asp Lys Asp Arg Thr 
    130                 135                 140                 


Phe Trp Arg Asn Val Leu Trp Ser Asp Glu Thr Lys Ile Glu Leu Phe 
145                 150                 155                 160 


Gly His Asn Asp His Arg Tyr Val Trp Arg Lys Lys Gly Glu Ala Cys 
                165                 170                 175     


Lys Pro Lys Asn Thr Ile Pro Thr Val Lys His Gly Gly Gly Ser Ile 
            180                 185                 190         


Met Leu Trp Gly Cys Phe Ala Ala Gly Gly Thr Gly Ala Leu His Lys 
        195                 200                 205             


Ile Asp Gly Ile Met Asp Ala Val Gln Tyr Val Asp Ile Leu Lys Gln 
    210                 215                 220                 


His Leu Lys Thr Ser Val Arg Lys Leu Lys Leu Gly Arg Lys Trp Val 
225                 230                 235                 240 


Phe Gln His Asp Asn Asp Pro Lys His Thr Ser Lys Val Val Ala Lys 
                245                 250                 255     


Trp Leu Lys Asp Asn Lys Val Lys Val Leu Glu Trp Pro Ser Gln Ser 
            260                 265                 270         


Pro Asp Leu Asn Pro Ile Glu Asn Leu Trp Ala Glu Leu Lys Lys Arg 
        275                 280                 285             


Val Arg Ala Arg Arg Pro Thr Asn Leu Thr Gln Leu His Gln Leu Cys 
    290                 295                 300                 


Gln Glu Glu Trp Ala Lys Ile His Pro Asn Tyr Cys Glu Lys Leu Val 
305                 310                 315                 320 


Glu Gly Tyr Pro Lys Arg Leu Thr Gln Val Lys Gln Phe Lys Gly Asn 
                325                 330                 335     


Ala Thr Lys Tyr 
            340 


<210>  10
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  10
ggtgaattcg ggctggaccc tgaacagcgc g                                      31


<210>  11
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  11
tatactcgag caggaatggc tgactctgca taaattggcc                             40


<210>  12
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  12
tataggatcc gccaccatga aatgcagctg ggttatc                                37


<210>  13
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  13
gggtccagcc cgaattcacc cctgtagaaa g                                      31


<210>  14
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  14
tataggatcc ctctgaggga cccagaaact                                        30


<210>  15
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  15
tatactcgag caggtcaggc tcttctcac                                         29


