                         SEQUENCE LISTING

<110>  Commonwealth Scientific and Industrial Research 
       Organisation
 
<120>  Measuring G protein coupled receptor activation

<130>  508883

<150>  61/148,271
<151>  2009-01-29

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  339
<212>  PRT
<213>  Caenorhabditis elegans

<400>  1

Met Ser Gly Glu Leu Trp Ile Thr Leu Val Asp Thr Ala Asp Ile Val 
1               5                   10                  15      


Gly Val Thr Leu Thr Phe Cys Val Asn Ile Val Leu Leu Gly Leu Leu 
            20                  25                  30          


Lys Thr Arg Gly Lys Asn Leu Gly Thr Tyr Lys Tyr Leu Met Ala Phe 
        35                  40                  45              


Phe Ser Val Phe Ser Ile Phe Tyr Ala Ile Ile Glu Phe Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asn Tyr Ser Thr Lys Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Val Ser Gly Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Thr Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro Thr Leu Leu Leu Trp Pro Leu Gly Cys Ser Val Pro Val Thr 
    130                 135                 140                 


Met Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Asn Val Leu Asn Asn His Tyr Asn Trp Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Val Arg His Ile Tyr Leu Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Met Phe Tyr Cys Gly Tyr 
    210                 215                 220                 


Ala Thr Trp Lys Thr Met Asn Glu His Lys Asp Val Ser Asp Arg Thr 
225                 230                 235                 240 


Arg Ala Leu Gln Lys Gln Leu Phe Lys Ala Leu Val Leu Gln Thr Leu 
                245                 250                 255     


Ile Pro Thr Ile Phe Met Tyr Ala Pro Thr Gly Val Met Phe Ile Ala 
            260                 265                 270         


Pro Phe Phe Asp Val Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe 
        275                 280                 285             


Cys Ser Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Leu Ile 
    290                 295                 300                 


Ile Arg Asp Phe Arg Arg Thr Ile Phe Asn Phe Leu Cys Gly Lys Lys 
305                 310                 315                 320 


Asn Ser Val Asp Glu Ser Arg Ser Thr Thr Arg Ala Asn Leu Ser Gln 
                325                 330                 335     


Val Pro Thr 
            


<210>  2
<211>  346
<212>  PRT
<213>  Caenorhabditis elegans

<400>  2

Met Ser Gly Gln Leu Trp Leu Ala Leu Val Asp Ala Ala Asp Met Val 
1               5                   10                  15      


Gly Phe Thr Leu Thr Ile Ser Ile Asn Ile Ile Leu Leu Gly Leu Ile 
            20                  25                  30          


Arg Thr Arg Gly Lys Thr Leu Gly Thr Tyr Lys Tyr Leu Met Ser Phe 
        35                  40                  45              


Phe Ser Phe Phe Ser Ile Phe Tyr Ala Ile Val Glu Ser Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asp Tyr Ser Thr Arg Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Leu Ser Ala Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Ala Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro His Leu Leu Leu Trp Pro Leu Met Cys Ser Ile Pro Val Thr 
    130                 135                 140                 


Ala Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Tyr Val Leu Lys Thr His Tyr Glu Val Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Glu Arg His Ile Tyr Ile Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Val Phe Tyr Cys Gly Phe 
    210                 215                 220                 


Ser Thr Trp Trp Thr Ile Arg Glu His Arg Gly Ala Ser Asp Arg Thr 
225                 230                 235                 240 


Arg His Leu His Arg Gln Leu Phe Lys Ala Leu Val Phe Gln Thr Leu 
                245                 250                 255     


Val Pro Ser Ile Phe Met Tyr Ile Pro Thr Gly Val Met Phe Ile Ala 
            260                 265                 270         


Pro Phe Phe Asp Ile Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe 
        275                 280                 285             


Cys Ser Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Phe Ile 
    290                 295                 300                 


Ile Arg Glu Phe Arg Val Thr Ile Leu Asn Ile Ile Arg Gly Asn Glu 
305                 310                 315                 320 


Arg Gly Asn Ala Val Gly Glu Ala Tyr Ser Thr Ser Arg Ile Lys Ser 
                325                 330                 335     


Ser Gln Pro Ala Ala Val Asn Leu Ser Gly 
            340                 345     


<210>  3
<211>  341
<212>  PRT
<213>  Caenorhabditis elegans

<400>  3

Met Ser Asp Arg His Trp Leu Asp Ile Thr Thr Tyr Ser Asp His Ile 
1               5                   10                  15      


Gly Phe Thr Ile Ser Thr Ile Ala Asn Phe Val Leu Ile Leu Leu Leu 
            20                  25                  30          


Val Phe Arg Pro Thr Lys Ser Tyr Gly Ser Tyr Lys Tyr Leu Met Ile 
        35                  40                  45              


Thr Phe Cys Val Phe Ser Leu Phe Tyr Thr Ser Ile Glu Thr Phe Leu 
    50                  55                  60                  


Arg Pro Leu Ile His Ile Tyr Asp Asn Thr Ile Phe Val Ile Gln Arg 
65                  70                  75                  80  


Lys Arg Phe Gln Tyr Ser Glu Gly Thr Ala Arg Ala Ile Ser Ser Thr 
                85                  90                  95      


Tyr Cys Gly Cys Tyr Ala Met Ser Phe Thr Leu Phe Ala Val His Phe 
            100                 105                 110         


Val Tyr Arg Tyr Tyr Ala Ala Cys Lys Pro Asp Asn Leu Arg Tyr Phe 
        115                 120                 125             


Gln Gly Cys Tyr Phe Val Ala Trp Val Phe Gly Ala Met Ala Val Ala 
    130                 135                 140                 


Ala Ser Trp Gly Phe Ala Ala Phe Ile Leu Tyr Pro Glu Thr Glu Arg 
145                 150                 155                 160 


Thr Arg Thr Ala Leu Ile His Val Ile Gln Thr Ser Tyr Glu Leu Asp 
                165                 170                 175     


Pro Glu Trp Val Gly Asn Val Pro Tyr Ser Tyr Trp Arg Thr Glu Asn 
            180                 185                 190         


Gly Val Glu Tyr Leu Asn Pro Arg Asn Val Ile Gly Ile Phe Gln His 
        195                 200                 205             


Gly Val Ile Met Ile Leu Ser Phe Gly Thr Val Phe Tyr Cys Gly Phe 
    210                 215                 220                 


Asn Thr Tyr Lys Thr Leu Asn Gly Ser Leu Gly Val Ser Glu Lys Thr 
225                 230                 235                 240 


Lys Glu Met His Thr Gln Leu Phe Lys Ala Leu Val Leu Gln Thr Ile 
                245                 250                 255     


Ile Pro Thr Thr Leu Met Tyr Ile Pro Thr Thr Met Leu Phe Val Thr 
            260                 265                 270         


Pro Phe Val Gly Leu Asn Ile Gly Cys Tyr Gly Asn Ile Thr Thr Ala 
        275                 280                 285             


Thr Val His Leu Tyr Pro Gly Ile Asp Pro Val Val Leu Ile Phe Ile 
    290                 295                 300                 


Ile Arg Asp Phe Arg Gln Thr Ile Leu Arg Pro Phe Arg Cys Phe Tyr 
305                 310                 315                 320 


Arg Ser Asn Ser Val Glu Asn Thr Ala Thr Ile Arg Gln Tyr Gln Gln 
                325                 330                 335     


Ser Ser Ser Lys Gly 
            340     


<210>  4
<211>  348
<212>  PRT
<213>  Caenorhabditis elegans

<400>  4

Met Ser Asp Ile Tyr Trp Ile Gln Ile Thr Glu Val Cys Ser Phe Val 
1               5                   10                  15      


Gly Phe Met Leu Ser Val Leu Gly Asn Ser Thr Leu Leu Val Leu Leu 
            20                  25                  30          


Ser Gly Lys Ser Ile Asp Gly Ile Gly Thr Tyr Arg Tyr Leu Met Ile 
        35                  40                  45              


Thr Phe Cys Val Phe Ser Leu Leu Phe Thr Ile Leu Glu Asp Phe Ile 
    50                  55                  60                  


Arg Pro Leu Met His His Tyr Asn Asn Thr Ile Ile Val Leu Gln Arg 
65                  70                  75                  80  


Lys Arg Phe Gln Phe Ser Asp Ser Thr Ala Arg Ile Leu Thr Val Ser 
                85                  90                  95      


Tyr Cys Gly Cys Phe Ala Met Cys Phe Val Met Phe Ala Val His Phe 
            100                 105                 110         


Ile Tyr Arg Tyr Leu Val Ala Cys His Pro Thr Lys Leu His Tyr Phe 
        115                 120                 125             


Arg Pro Lys Asn Phe Ile Phe Trp Leu Ser Gly Met Leu Phe Ile Ala 
    130                 135                 140                 


Gly Ser Trp Val Ala Ile Ala Tyr Val Phe Phe Gln Glu Asp Leu Glu 
145                 150                 155                 160 


Thr Arg Thr Asp Leu Val Phe Ile Leu Ser Thr Cys Tyr Asn Leu Thr 
                165                 170                 175     


Pro Asp Asp Val Gly His Val Pro Tyr Ala Phe Tyr Lys Thr Gln Gly 
            180                 185                 190         


Asn Thr Arg Val Ile Arg Trp Asp Asn Met Ile Gly Val Ile His His 
        195                 200                 205             


Met Ile Val Met Thr Ile Ser Ile Ser Ala Val Phe Tyr Phe Gly Ile 
    210                 215                 220                 


Lys Thr Tyr Thr Arg Ile Met Ser Phe Lys Gly Lys Ser Gln Lys Thr 
225                 230                 235                 240 


Lys Asp Leu Gln Asn Gln Phe Phe Thr Ala Leu Val Ala Gln Thr Val 
                245                 250                 255     


Val Pro Leu Ile Phe Met Phe Ile Pro Asn Met Val Leu Thr Thr Ala 
            260                 265                 270         


Ala Leu Ile Asp Gly Thr Phe Gly Ser Trp Ala Asn Ile Thr Val Val 
        275                 280                 285             


Met Asn His Leu Tyr Pro Ala Ala Asp Pro Phe Val Ile Leu Phe Ile 
    290                 295                 300                 


Ile Lys Gly Phe Arg Asn Ser Ile Arg Asn Val Ile Tyr Arg Cys Thr 
305                 310                 315                 320 


Lys Thr Lys Lys Ala Ser Val Ser Ser Val Val Arg Gly Ile Glu Ala 
                325                 330                 335     


Gln Ser Lys Lys Gln Ser Phe Ser Arg Val Asp Ile 
            340                 345             


<210>  5
<211>  334
<212>  PRT
<213>  Caenorhabditis elegans

<400>  5

Met Thr Asp Gln His Trp Val Ile Ile Thr Asp Ile Ala Gly Pro Ile 
1               5                   10                  15      


Gly Phe Ser Met Ser Ile Phe Ser Asn Ser Ile Leu Leu Phe Leu Ile 
            20                  25                  30          


Phe Ser His Ser Ser Pro Ile Lys Gly Pro Tyr Lys Arg Met Leu Ile 
        35                  40                  45              


Val Phe Cys Ile Phe Thr Val Phe Tyr Ser Phe Val Glu Val Met Leu 
    50                  55                  60                  


Gln Pro Leu Ile His Ile Tyr Asp Asp Thr Leu Phe Leu Ile His Arg 
65                  70                  75                  80  


Lys Arg Ile Asp Leu Pro Lys Trp Leu Thr Arg Leu Val Pro Thr Thr 
                85                  90                  95      


Tyr Cys Trp Cys Tyr Ala Met Ser Phe Ser Leu Phe Ala Leu Gln Phe 
            100                 105                 110         


Leu Tyr Arg Tyr Val Ala Val Cys Lys Pro Gln Tyr Val Asp Leu Phe 
        115                 120                 125             


Val Gly Cys His Phe Tyr Ala Trp Val Val Leu Ile Leu Ser Leu Ala 
    130                 135                 140                 


Thr Ser Trp Gly Leu Thr Ala Ala Phe Met Phe Pro Gln Thr Asp Arg 
145                 150                 155                 160 


Thr Thr Glu Ile Phe Leu His Ile Ile Tyr Ser Ser Tyr Asp Leu Glu 
                165                 170                 175     


Pro Tyr Trp Thr Asp Tyr Val Ala Tyr Lys Tyr Phe Asp Thr Asp Glu 
            180                 185                 190         


Asn Asn Val Arg Trp Val Asn Val Leu Ser Phe Phe Gly Val Leu Gln 
        195                 200                 205             


His Gly Ile Val Ile Thr Leu Ser Phe Gly Thr Leu Tyr Tyr Cys Gly 
    210                 215                 220                 


Ile Asn Thr Tyr Leu Lys Ile Lys Lys His Thr Gly Thr Ser Asn Arg 
225                 230                 235                 240 


Thr Arg Cys Ile Gln Leu Gln Leu Phe Arg Ala Leu Val Ala Gln Thr 
                245                 250                 255     


Ile Leu Pro Met Phe Met Met Tyr Ile Pro Val Gly Phe Met Phe Ala 
            260                 265                 270         


Cys Pro Tyr Phe Asp Leu Gln Leu Gly Ala Tyr Thr Asn Tyr Gln Thr 
        275                 280                 285             


Val Met Ala Gln Leu Tyr Pro Gly Ile Asp Pro Phe Val Met Leu Phe 
    290                 295                 300                 


Leu Ile Asp Ser Tyr Arg Ile Thr Ile Phe Gly Trp Leu Cys Pro Arg 
305                 310                 315                 320 


Phe Val Tyr Val Lys Pro Met His Ser Thr Tyr Thr Leu Thr 
                325                 330                 


<210>  6
<211>  350
<212>  PRT
<213>  Caenorhabditis elegans

<400>  6

Met Thr Asp Arg Arg Trp Val Ala Ile Thr Asp Ile Ala Gly Pro Ile 
1               5                   10                  15      


Gly Phe Thr Met Ser Ile Phe Ser Asn Ser Val Leu Leu Ser Leu Ile 
            20                  25                  30          


Phe Ser Ser Ser Ser Pro Ile Lys Gly Ala Tyr Lys Asn Met Leu Ile 
        35                  40                  45              


Val Leu Cys Ile Phe Thr Met Phe Tyr Ser Phe Val Glu Ile Met Leu 
    50                  55                  60                  


Gln Pro Leu Ile His Ile Tyr Asp Asp Thr Leu Phe Leu Ile His Arg 
65                  70                  75                  80  


Lys Arg Phe Asp Leu Ser Lys Gly Ile Thr Arg Leu Ile Pro Thr Thr 
                85                  90                  95      


Tyr Cys Trp Cys Tyr Ala Met Ser Phe Ser Leu Phe Ala Leu Gln Phe 
            100                 105                 110         


Leu Tyr Arg Tyr Val Ala Val Cys Lys Pro His Leu Val Val Phe Phe 
        115                 120                 125             


Thr Gly Cys Tyr Phe Tyr Tyr Trp Leu Ala Leu Ile Leu Ser Leu Ala 
    130                 135                 140                 


Thr Ser Trp Gly Leu Thr Ala Ala Phe Met Phe Pro Gln Thr Asn Arg 
145                 150                 155                 160 


Thr Thr Glu Ser Phe Asn Tyr Val Ile Lys Thr Ser Tyr Asp Leu Asp 
                165                 170                 175     


Pro Tyr Trp Thr Asp Tyr Val Ala Tyr Lys Tyr Phe Asp Thr Asp Glu 
            180                 185                 190         


Asn His Val Arg Trp Val Asn Val Leu Ser Leu Phe Gly Val Leu Gln 
        195                 200                 205             


His Gly Leu Val Ile Thr Leu Ser Phe Gly Thr Leu Phe Tyr Cys Gly 
    210                 215                 220                 


Ile Lys Thr Tyr Leu Ser Ile Thr Glu His Val Gly Met Ser Ser Lys 
225                 230                 235                 240 


Thr Arg Ser Leu Gln Leu Gln Leu Phe Arg Ala Leu Val Ala Gln Thr 
                245                 250                 255     


Cys Leu Pro Met Leu Met Met Tyr Met Pro Ile Gly Phe Met Phe Ser 
            260                 265                 270         


Cys Pro Tyr Phe Asp Leu Gln Leu Gly Ala Val Thr Asn Tyr Gln Thr 
        275                 280                 285             


Val Met Ala Gln Leu Tyr Pro Gly Ile Asp Pro Phe Met Leu Leu Phe 
    290                 295                 300                 


Leu Ile Asn Ala Tyr Arg Lys Thr Val Leu Ser Leu Ile Cys Pro Asn 
305                 310                 315                 320 


Phe Ile Gln Lys Lys Tyr Val Gln Thr Ala Thr Thr Arg Asp Gly Thr 
                325                 330                 335     


Asp Ala Ser Ala Thr Met Asn Ser Val Lys Ser Thr Gln Leu 
            340                 345                 350 


<210>  7
<211>  1020
<212>  DNA
<213>  Caenorhabditis elegans

<400>  7
atgtcgggag aattgtggat taccctagtt gacacagcgg acattgtcgg cgtcaccctc       60

accttctgtg tcaacattgt tcttctcgga cttctgaaaa cacgtggaaa aaacttgggc      120

acttataaat atctcatggc gtttttctca gtattctcga ttttttacgc catcatcgag      180

ttcatattac gacctataat gcatattgag aacaccactt tctttttgat ctcaaggaaa      240

agattcaact actccaccaa acttggaaaa atcaactctg cgttttactg tgcttgtttt      300

gccaccagtt ttgttgtctc aggagttcac tttgtttatc gatattttgc aacttgcaaa      360

ccgaatctac ttcgtttgtt caacttgcca actcttctac tttggccact tggttgcagt      420

gtacccgtga caatgtgggc tagtgtctca tattttttgt atccagatac cgagtacacg      480

gaagcggctg tcaccaatgt actaaataac cactataact ggatcaaaaa ggagaatgta      540

tcgtacattg catacgtcta ttaccaatac gaaaacggag taaggcatat ctacctcaaa      600

aacttgcttg gatgctttgt tcattacttt gtcatgtcga tgacgtttgt tgtgatgttc      660

tactgcggat atgccacgtg gaaaactatg aatgaacaca aggatgtatc tgatagaact      720

cgagcgctac agaaacaact tttcaaagct ttagttcttc agacactcat cccaactatc      780

ttcatgtacg ccccaactgg agtcatgttc atcgcaccgt tttttgacgt gaatttgaat      840

gcaaacgcca atttcattgt gttttgctca tttctgtacc cgggactcga tccactcatt      900

ctgattttga tcattcgtga tttccgaaga acaatattca atttcttgtg tggaaagaaa      960

aacagtgttg atgaatcccg ctcgacaaca agagccaatt tgtctcaagt tccgacgtga     1020


<210>  8
<211>  1040
<212>  DNA
<213>  Caenorhabditis elegans

<400>  8
atgtctggtc aattatggtt ggccctcgtg gatgctgccg atatggtagg attcactctc       60

acgatctcca tcaacatcat tctactgggg ctgattagaa cacgtggaaa aacgttggga      120

acgtacaaat acttgatgag cttcttctcg ttcttctcaa tcttttatgc aatcgttgaa      180

tctattttga gaccaataat gcatatcgaa aacacgacgt tctttctgat ttctcggaaa      240

cgcttcgatt actcaactcg ccttggtaaa atcaactctg ctttctactg tgcttgtttt      300

gccacgagtt ttgtcctgtc tgcggtacac tttgtgtatc ggtactttgc cgcttgcaaa      360

ccgaatctgc tacgcttgtt taaccttccg catcttttac tgtggccttt gatgtgttcg      420

attcctgtga ctgcgtgggc aagtgtttct tactttttgt acccagacac cgagtacact      480

gaagcagcag ttacatatgt tctgaaaaca cactacgagg tgatcaaaaa agaaaatgta      540

tcttatatcg catacgtata ctatcaatat gaaaatgggg agcgtcacat ctacataaaa      600

aatttgcttg gctgctttgt acactacttc gttatgtcaa tgacatttgt agttgtgttt      660

tactgcggat tttctacatg gtggacgatt cgtgagcatc gtggagcatc tgataggaca      720

cgtcacctgc atagacaatt gtttaaggca cttgtatttc aaacccttgt tccatcaata      780

tttatgtaca tcccaactgg tgtcatgttc atcgctccct ttttcgacat caacctgaat      840

gccaatgcaa acttcatcgt tttttgctca tttctctatc caggtcttga cccactaatt      900

ctcattttta tcattcgcga attcgggtca ctattttgaa tatcatcaga ggaaatgagc      960

ggggaaatgc tgttggcgaa gcatactcaa cttctcgaat aaaatcatca caacctgcag     1020

ctgttaatct ttctggataa                                                 1040


<210>  9
<211>  1026
<212>  DNA
<213>  Caenorhabditis elegans

<400>  9
atgtctgacc gtcattggct cgacatcacc acctactcag accacattgg gtttacgatt       60

tccaccatcg ccaatttcgt tctgatcctt ctgctagtct tccgaccgac caaatcatac      120

ggttcataca agtacctgat gatcacattc tgcgtgttca gcctctttta cacctccatt      180

gaaacttttt tgagacctct catccatatc tacgacaata cgatcttcgt gattcagcgc      240

aagagattcc agtactccga gggtaccgct agagccattt catcgaccta ctgcggctgc      300

tacgccatga gcttcaccct gttcgccgtc cactttgtct accgttacta tgcggcttgc      360

aaacccgaca acctccgtta cttccaagga tgctactttg tcgcatgggt attcggagca      420

atggcggtgg cggcgagctg ggggttcgca gcgtttattc tgtacccgga gaccgagagg      480

accaggacgg cgttgataca cgtcatacaa acatcctatg agctggatcc cgagtgggtg      540

ggaaatgttc catatagcta ttggcgcaca gaaaacggag tggaatacct gaatcctcgc      600

aacgtcatcg ggatctttca acacggcgtc atcatgatcc tctccttcgg aacagtcttc      660

tactgcggat tcaacactta taagactttg aacggaagtc tgggggtgtc tgaaaaaaca      720

aaagaaatgc acacccaatt gttcaaggcc ttggttctac agactatcat ccctactaca      780

ctaatgtaca tcccgacaac catgctcttt gtcaccccat tcgttggact caacatcggc      840

tgttacggca acatcactac tgccaccgtc catttgtatc ctggaattga cccagtcgtt      900

ttgatcttta taatccgaga cttccggcaa acgattttaa gaccattcag atgcttctac      960

cgttcaaata gtgtcgaaaa cactgccacc ataaggcaat accagcagag cagctccaaa     1020

ggataa                                                                1026


<210>  10
<211>  1047
<212>  DNA
<213>  Caenorhabditis elegans

<400>  10
atgtccgata tatactggat acaaattact gaagtttgct ccttcgtcgg atttatgctc       60

tcagttctag ggaacagtac acttttagta ctgctcagtg gaaaatccat agatggaatt      120

ggcacctatc ggtacttgat gatcactttc tgcgttttca gtttattatt tacgatatta      180

gaggatttta tcagaccgct gatgcatcac tataacaata ccataattgt tttacaacgc      240

aagcggtttc agttttctga ttcaacggct agaatcttga cagtctctta ctgcggctgt      300

ttcgcgatgt gcttcgtgat gttcgccgtt catttcatct atcgatatct agttgcttgt      360

cacccgacaa aattgcacta ttttcgaccc aaaaatttca ttttctggct gtccggcatg      420

ttattcatag caggaagctg ggttgcaatt gcatatgtct tttttcaaga agacctagaa      480

accaggacgg atttggtatt tattttgtca acttgttata atttaacgcc agatgatgtc      540

ggacatgtac cgtatgcttt ttacaaaact caaggaaata cacgagtaat tcgatgggat      600

aacatgattg gagtaattca tcatatgata gttatgacaa tctctataag tgccgttttc      660

tactttggca ttaaaaccta cactcgaata atgagtttca agggaaaatc ccagaaaacc      720

aaggatctcc agaatcaatt tttcactgct ctagttgctc aaaccgtagt ccctctgatt      780

ttcatgttta tcccaaatat ggtgctcact acggcagccc ttatagatgg cacatttggc      840

tcatgggcca atattactgt agttatgaat catttgtatc cggctgccga tccattcgtt      900

atactgttca ttattaaggg gttccggaat agtattagaa atgttatata tcgctgcaca      960

aaaacgaaaa aagcatcggt tagctcagtg gtccgtggta ttgaggctca aagcaagaaa     1020

caatcttttt ctcgagttga tatttaa                                         1047


<210>  11
<211>  1005
<212>  DNA
<213>  Caenorhabditis elegans

<400>  11
atgactgatc aacactgggt tattatcaca gatattgctg gtccaatcgg attttcaatg       60

tccatttttt caaactctat tcttttgttt ttgatatttt cacattcatc tccaataaaa      120

ggtccataca aacgaatgct catagtattt tgcatattta ccgtattcta ctcatttgtc      180

gaagtcatgc ttcagccact aatccatatt tacgacgaca ctttattttt gattcatcga      240

aagagaatag acttgccaaa atggttaaca cgtttggttc ctactaccta ttgttggtgt      300

tacgcaatga gtttttcctt gtttgcatta caatttttat atagatatgt ggcagtatgc      360

aaaccgcaat atgttgatct ttttgtcgga tgtcactttt atgcttgggt agttttgatc      420

ttatcactag ccacgagctg gggactcact gcagctttca tgttcccaca aaccgaccga      480

acaactgaaa tttttttgca cataatttat agttcatatg acttggagcc ttattggaca      540

gattatgttg cttataaata ctttgatact gatgagaata atgtgagatg ggtcaatgtt      600

cttagttttt tcggtgtcct tcagcacggg attgtaatta ctctaagttt tggcaccctt      660

tattattgtg gcatcaacac gtatctcaaa ataaaaaaac acactggaac atcaaacaga      720

actcgatgta ttcaactaca acttttcaga gctctggttg cacagacaat tttaccaatg      780

ttcatgatgt atattcccgt tggtttcatg tttgcatgtc catattttga cttgcaatta      840

ggtgcataca ccaattatca aacagtcatg gcacaacttt atccgggaat cgacccattt      900

gtgatgctgt ttttgataga ttcttataga ataacaatat ttggatggtt atgtccaaga      960

tttgtttatg taaagccgat gcattccaca tacaccctaa cttga                     1005


<210>  12
<211>  1053
<212>  DNA
<213>  Caenorhabditis elegans

<400>  12
atgaccgatc gtcgctgggt cgctattacg gacattgccg gaccgattgg gttcacaatg       60

tcaatttttt cgaactcggt gctgttatcg ttgatattct caagcagctc tccaattaaa      120

ggagcttaca aaaatatgtt gatagtgttg tgtatattca ctatgttcta ctcttttgtt      180

gaaataatgc ttcaaccgtt gattcatatt tatgatgaca cgctgttctt gatccaccgg      240

aaaagatttg acctgtctaa aggaattaca cgtttgatac ctacaacata ttgttggtgt      300

tatgcaatga gtttctcatt attcgccctc cagtttttgt acagatatgt ggcagtttgc      360

aaacctcact tagttgtttt ttttactgga tgctatttct attattggtt ggcactcatc      420

ttatcacttg ctacaagttg ggggcttact gcagctttta tgttcccgca aaccaatcga      480

acaactgaaa gcttcaacta cgtaataaaa acttcttatg acttagatcc ttattggacg      540

gattatgttg cctataaata ttttgacacc gatgagaatc atgtgagatg ggtgaatgtt      600

cttagtttat ttggagtctt gcagcacgga ttagtaatta cgttgagttt tggaacctta      660

ttctactgtg gaattaaaac ttatctcagc attactgaac atgttggaat gtccagcaag      720

acccgaagtc ttcaacttca actattccgt gctttagttg ctcagacatg tcttccaatg      780

ctcatgatgt acatgccaat aggattcatg ttttcttgcc cttactttga tttgcaactt      840

ggagcagtca caaactatca aaccgtcatg gcacagttat acccaggaat cgacccattt      900

atgttgctat ttcttattaa cgcctacaga aagacagtgt taagcttgat ctgtcctaat      960

tttatccaga aaaaatatgt tcaaacggca actactcgtg atggcacaga tgcctcggca     1020

acaatgaatt ctgttaaatc tacacagtta taa                                  1053


<210>  13
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRET construct

<400>  13

Met Ser Gly Glu Leu Trp Ile Thr Leu Val Asp Thr Ala Asp Ile Val 
1               5                   10                  15      


Gly Val Thr Leu Thr Phe Cys Val Asn Ile Val Leu Leu Gly Leu Leu 
            20                  25                  30          


Lys Thr Arg Gly Lys Asn Leu Gly Thr Tyr Lys Tyr Leu Met Ala Phe 
        35                  40                  45              


Phe Ser Val Phe Ser Ile Phe Tyr Ala Ile Ile Glu Phe Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asn Tyr Ser Thr Lys Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Val Ser Gly Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Thr Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro Thr Leu Leu Leu Trp Pro Leu Gly Cys Ser Val Pro Val Thr 
    130                 135                 140                 


Met Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Asn Val Leu Asn Asn His Tyr Asn Trp Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Val Arg His Ile Tyr Leu Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Met Phe Tyr Cys Gly Tyr 
    210                 215                 220                 


Ala Thr Trp Lys Thr Met Asn Glu His Lys Asp Val Ser Asp Arg Thr 
225                 230                 235                 240 


Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
                245                 250                 255     


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            260                 265                 270         


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        275                 280                 285             


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    290                 295                 300                 


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
305                 310                 315                 320 


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                325                 330                 335     


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            340                 345                 350         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        355                 360                 365             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    370                 375                 380                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
385                 390                 395                 400 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                405                 410                 415     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            420                 425                 430         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        435                 440                 445             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    450                 455                 460                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
465                 470                 475                 480 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                485                 490                 495     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            500                 505                 510         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        515                 520                 525             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    530                 535                 540                 


Arg Val Leu Lys Asn Glu Gln Arg Ala Leu Gln Lys Gln Leu Phe Lys 
545                 550                 555                 560 


Ala Leu Val Leu Gln Thr Leu Ile Pro Thr Ile Phe Met Tyr Ala Pro 
                565                 570                 575     


Thr Gly Val Met Phe Ile Ala Pro Phe Phe Asp Val Asn Leu Asn Ala 
            580                 585                 590         


Asn Ala Asn Phe Ile Val Phe Cys Ser Phe Leu Tyr Pro Gly Leu Asp 
        595                 600                 605             


Pro Leu Ile Leu Ile Leu Ile Ile Arg Asp Phe Arg Arg Thr Ile Phe 
    610                 615                 620                 


Asn Phe Leu Cys Gly Lys Lys Asn Ser Val Asp Glu Ser Arg Ser Thr 
625                 630                 635                 640 


Thr Arg Ala Asn Leu Ser Gln Val Pro Thr Met Val Ser Lys Gly Glu 
                645                 650                 655     


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            660                 665                 670         


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        675                 680                 685             


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    690                 695                 700                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln 
705                 710                 715                 720 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                725                 730                 735     


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
            740                 745                 750         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        755                 760                 765             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    770                 775                 780                 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
785                 790                 795                 800 


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
                805                 810                 815     


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            820                 825                 830         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        835                 840                 845             


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    850                 855                 860                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
865                 870                 875                 880 


Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                885                 


<210>  14
<211>  2670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding BRET construct of SEQ ID NO:13

<400>  14
atgtcgggag aattgtggat taccctagtt gacacagcgg acattgtcgg cgtcaccctc       60

accttctgtg tcaacattgt tcttctcgga cttctgaaaa cacgtggaaa aaacttgggc      120

acttataaat atctcatggc gtttttctca gtattctcga ttttttacgc catcatcgag      180

ttcatattac gacctataat gcatattgag aacaccactt tctttttgat ctcaaggaaa      240

agattcaact actccaccaa acttggaaaa atcaactctg cgttttactg tgcttgtttt      300

gccaccagtt ttgttgtctc aggagttcac tttgtttatc gatattttgc aacttgcaaa      360

ccgaatctac ttcgtttgtt caacttgcca actcttctac tttggccact tggttgcagt      420

gtacccgtga caatgtgggc tagtgtctca tattttttgt atccagatac cgagtacacg      480

gaagcggctg tcaccaatgt actaaataac cactataact ggatcaaaaa ggagaatgta      540

tcgtacattg catacgtcta ttaccaatac gaaaacggag taaggcatat ctacctcaaa      600

aacttgcttg gatgctttgt tcattacttt gtcatgtcga tgacgtttgt tgtgatgttc      660

tactgcggat atgccacgtg gaaaactatg aatgaacaca aggatgtatc tgatagaact      720

atgaccagca aggtgtacga ccccgagcag aggaagagga tgatcaccgg cccccagtgg      780

tgggccaggt gcaagcagat gaacgtgctg gacagcttca tcaactacta cgacagcgag      840

aagcacgccg agaacgccgt gatcttcctg cacggcaacg ccgctagcag ctacctgtgg      900

aggcacgtgg tgccccacat cgagcccgtg gccaggtgca tcatccccga tctgatcggc      960

atgggcaaga gcggcaagag cggcaacggc agctacaggc tgctggacca ctacaagtac     1020

ctgaccgcct ggttcgagct cctgaacctg cccaagaaga tcatcttcgt gggccacgac     1080

tggggcgcct gcctggcctt ccactacagc tacgagcacc aggacaagat caaggccatc     1140

gtgcacgccg agagcgtggt ggacgtgatc gagagctggg acgagtggcc agacatcgag     1200

gaggacatcg ccctgatcaa gagcgaggag ggcgagaaga tggtgctgga gaacaacttc     1260

ttcgtggaga ccatgctgcc cagcaagatc atgagaaagc tggagcccga ggagttcgcc     1320

gcctacctgg agcccttcaa ggagaagggc gaggtgagaa gacccaccct gagctggccc     1380

agagagatcc ccctggtgaa gggcggcaag cccgacgtgg tgcagatcgt gagaaactac     1440

aacgcctacc tgagagccag cgacgacctg cccaagatgt tcatcgagag cgaccccggc     1500

ttcttcagca acgccatcgt ggagggcgcc aagaagttcc ccaacaccga gttcgtgaag     1560

gtgaagggcc tgcacttcag ccaggaggac gcccccgacg agatgggcaa gtacatcaag     1620

agcttcgtgg agagagtgct gaagaacgag cagcgagcgc tacagaaaca acttttcaaa     1680

gctttagttc ttcagacact catcccaact atcttcatgt acgccccaac tggagtcatg     1740

ttcatcgcac cgttttttga cgtgaatttg aatgcaaacg ccaatttcat tgtgttttgc     1800

tcatttctgt acccgggact cgatccactc attctgattt tgatcattcg tgatttccga     1860

agaacaatat tcaatttctt gtgtggaaag aaaaacagtg ttgatgaatc ccgctcgaca     1920

acaagagcca atttgtctca agttccgacg atggtgagca agggcgagga gctgttcacc     1980

ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg     2040

tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc     2100

accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgagcta cggcgtgcag     2160

tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc     2220

gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc     2280

gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac     2340

ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac     2400

gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac     2460

aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc     2520

gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa     2580

gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc     2640

actctcggca tggacgagct gtacaagtaa                                      2670


<210>  15
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRET construct

<400>  15

Met Ser Gly Glu Leu Trp Ile Thr Leu Val Asp Thr Ala Asp Ile Val 
1               5                   10                  15      


Gly Val Thr Leu Thr Phe Cys Val Asn Ile Val Leu Leu Gly Leu Leu 
            20                  25                  30          


Lys Thr Arg Gly Lys Asn Leu Gly Thr Tyr Lys Tyr Leu Met Ala Phe 
        35                  40                  45              


Phe Ser Val Phe Ser Ile Phe Tyr Ala Ile Ile Glu Phe Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asn Tyr Ser Thr Lys Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Val Ser Gly Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Thr Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro Thr Leu Leu Leu Trp Pro Leu Gly Cys Ser Val Pro Val Thr 
    130                 135                 140                 


Met Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Asn Val Leu Asn Asn His Tyr Asn Trp Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Val Arg His Ile Tyr Leu Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Met Phe Tyr Cys Gly Tyr 
    210                 215                 220                 


Ala Thr Trp Lys Thr Met Asn Glu His Lys Asp Val Ser Asp Arg Thr 
225                 230                 235                 240 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                245                 250                 255     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            260                 265                 270         


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        275                 280                 285             


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    290                 295                 300                 


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
305                 310                 315                 320 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                325                 330                 335     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            340                 345                 350         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        355                 360                 365             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    370                 375                 380                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
385                 390                 395                 400 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                405                 410                 415     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            420                 425                 430         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        435                 440                 445             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    450                 455                 460                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg 
465                 470                 475                 480 


Ala Leu Gln Lys Gln Leu Phe Lys Ala Leu Val Leu Gln Thr Leu Ile 
                485                 490                 495     


Pro Thr Ile Phe Met Tyr Ala Pro Thr Gly Val Met Phe Ile Ala Pro 
            500                 505                 510         


Phe Phe Asp Val Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe Cys 
        515                 520                 525             


Ser Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Leu Ile Ile 
    530                 535                 540                 


Arg Asp Phe Arg Arg Thr Ile Phe Asn Phe Leu Cys Gly Lys Lys Asn 
545                 550                 555                 560 


Ser Val Asp Glu Ser Arg Ser Thr Thr Arg Ala Asn Leu Ser Gln Val 
                565                 570                 575     


Pro Thr Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met 
            580                 585                 590         


Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu 
        595                 600                 605             


Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala 
    610                 615                 620                 


Val Ile Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His 
625                 630                 635                 640 


Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu 
                645                 650                 655     


Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu 
            660                 665                 670         


Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu 
        675                 680                 685             


Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala 
    690                 695                 700                 


Phe His Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His 
705                 710                 715                 720 


Ala Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp 
                725                 730                 735     


Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met 
            740                 745                 750         


Val Leu Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile 
        755                 760                 765             


Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe 
    770                 775                 780                 


Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu 
785                 790                 795                 800 


Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg 
                805                 810                 815     


Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe 
            820                 825                 830         


Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala 
        835                 840                 845             


Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe 
    850                 855                 860                 


Ser Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe 
865                 870                 875                 880 


Val Glu Arg Val Leu Lys Asn Glu Gln 
                885                 


<210>  16
<211>  2670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding BRET construct of SEQ ID NO:15

<400>  16
atgtcgggag aattgtggat taccctagtt gacacagcgg acattgtcgg cgtcaccctc       60

accttctgtg tcaacattgt tcttctcgga cttctgaaaa cacgtggaaa aaacttgggc      120

acttataaat atctcatggc gtttttctca gtattctcga ttttttacgc catcatcgag      180

ttcatattac gacctataat gcatattgag aacaccactt tctttttgat ctcaaggaaa      240

agattcaact actccaccaa acttggaaaa atcaactctg cgttttactg tgcttgtttt      300

gccaccagtt ttgttgtctc aggagttcac tttgtttatc gatattttgc aacttgcaaa      360

ccgaatctac ttcgtttgtt caacttgcca actcttctac tttggccact tggttgcagt      420

gtacccgtga caatgtgggc tagtgtctca tattttttgt atccagatac cgagtacacg      480

gaagcggctg tcaccaatgt actaaataac cactataact ggatcaaaaa ggagaatgta      540

tcgtacattg catacgtcta ttaccaatac gaaaacggag taaggcatat ctacctcaaa      600

aacttgcttg gatgctttgt tcattacttt gtcatgtcga tgacgtttgt tgtgatgttc      660

tactgcggat atgccacgtg gaaaactatg aatgaacaca aggatgtatc tgatagaact      720

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      780

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      840

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      900

ctcgtgacca ccctgagcta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      960

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc     1020

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg     1080

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac     1140

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac     1200

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc     1260

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     1320

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc     1380

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagcga     1440

gcgctacaga aacaactttt caaagcttta gttcttcaga cactcatccc aactatcttc     1500

atgtacgccc caactggagt catgttcatc gcaccgtttt ttgacgtgaa tttgaatgca     1560

aacgccaatt tcattgtgtt ttgctcattt ctgtacccgg gactcgatcc actcattctg     1620

attttgatca ttcgtgattt ccgaagaaca atattcaatt tcttgtgtgg aaagaaaaac     1680

agtgttgatg aatcccgctc gacaacaaga gccaatttgt ctcaagttcc gacgatgacc     1740

agcaaggtgt acgaccccga gcagaggaag aggatgatca ccggccccca gtggtgggcc     1800

aggtgcaagc agatgaacgt gctggacagc ttcatcaact actacgacag cgagaagcac     1860

gccgagaacg ccgtgatctt cctgcacggc aacgccgcta gcagctacct gtggaggcac     1920

gtggtgcccc acatcgagcc cgtggccagg tgcatcatcc ccgatctgat cggcatgggc     1980

aagagcggca agagcggcaa cggcagctac aggctgctgg accactacaa gtacctgacc     2040

gcctggttcg agctcctgaa cctgcccaag aagatcatct tcgtgggcca cgactggggc     2100

gcctgcctgg ccttccacta cagctacgag caccaggaca agatcaaggc catcgtgcac     2160

gccgagagcg tggtggacgt gatcgagagc tgggacgagt ggccagacat cgaggaggac     2220

atcgccctga tcaagagcga ggagggcgag aagatggtgc tggagaacaa cttcttcgtg     2280

gagaccatgc tgcccagcaa gatcatgaga aagctggagc ccgaggagtt cgccgcctac     2340

ctggagccct tcaaggagaa gggcgaggtg agaagaccca ccctgagctg gcccagagag     2400

atccccctgg tgaagggcgg caagcccgac gtggtgcaga tcgtgagaaa ctacaacgcc     2460

tacctgagag ccagcgacga cctgcccaag atgttcatcg agagcgaccc cggcttcttc     2520

agcaacgcca tcgtggaggg cgccaagaag ttccccaaca ccgagttcgt gaaggtgaag     2580

ggcctgcact tcagccagga ggacgccccc gacgagatgg gcaagtacat caagagcttc     2640

gtggagagag tgctgaagaa cgagcagtaa                                      2670


<210>  17
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRET construct

<400>  17

Met Ser Gly Glu Leu Trp Ile Thr Leu Val Asp Thr Ala Asp Ile Val 
1               5                   10                  15      


Gly Val Thr Leu Thr Phe Cys Val Asn Ile Val Leu Leu Gly Leu Leu 
            20                  25                  30          


Lys Thr Arg Gly Lys Asn Leu Gly Thr Tyr Lys Tyr Leu Met Ala Phe 
        35                  40                  45              


Phe Ser Val Phe Ser Ile Phe Tyr Ala Ile Ile Glu Phe Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asn Tyr Ser Thr Lys Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Val Ser Gly Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Thr Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro Thr Leu Leu Leu Trp Pro Leu Gly Cys Ser Val Pro Val Thr 
    130                 135                 140                 


Met Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Asn Val Leu Asn Asn His Tyr Asn Trp Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Val Arg His Ile Tyr Leu Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Met Phe Tyr Cys Gly Tyr 
    210                 215                 220                 


Ala Thr Trp Lys Thr Met Asn Glu His Lys Asp Val Ser Asp Arg Thr 
225                 230                 235                 240 


Arg Ala Leu Gln Lys Gln Leu Phe Lys Ala Leu Val Leu Gln Thr Leu 
                245                 250                 255     


Ile Pro Thr Ile Phe Met Tyr Ala Pro Thr Gly Val Met Phe Ile Ala 
            260                 265                 270         


Pro Phe Phe Asp Val Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe 
        275                 280                 285             


Cys Ser Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Leu Ile 
    290                 295                 300                 


Ile Arg Asp Phe Arg Arg Thr Ile Phe Asn Phe Leu Cys Gly Lys Lys 
305                 310                 315                 320 


Asn Ser Val Asp Glu Ser Arg Ser Thr Thr Arg Ala Asn Leu Ser Gln 
                325                 330                 335     


Val Pro Thr Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg 
            340                 345                 350         


Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val 
        355                 360                 365             


Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn 
    370                 375                 380                 


Ala Val Ile Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg 
385                 390                 395                 400 


His Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp 
                405                 410                 415     


Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg 
            420                 425                 430         


Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn 
        435                 440                 445             


Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu 
    450                 455                 460                 


Ala Phe His Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val 
465                 470                 475                 480 


His Ala Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro 
                485                 490                 495     


Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys 
            500                 505                 510         


Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys 
        515                 520                 525             


Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro 
    530                 535                 540                 


Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg 
545                 550                 555                 560 


Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val 
                565                 570                 575     


Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met 
            580                 585                 590         


Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly 
        595                 600                 605             


Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His 
    610                 615                 620                 


Phe Ser Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser 
625                 630                 635                 640 


Phe Val Glu Arg Val Leu Lys Asn Glu Gln 
                645                 650 


<210>  18
<211>  1953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding BRET construct of SEQ ID NO:17

<400>  18
atgtcgggag aattgtggat taccctagtt gacacagcgg acattgtcgg cgtcaccctc       60

accttctgtg tcaacattgt tcttctcgga cttctgaaaa cacgtggaaa aaacttgggc      120

acttataaat atctcatggc gtttttctca gtattctcga ttttttacgc catcatcgag      180

ttcatattac gacctataat gcatattgag aacaccactt tctttttgat ctcaaggaaa      240

agattcaact actccaccaa acttggaaaa atcaactctg cgttttactg tgcttgtttt      300

gccaccagtt ttgttgtctc aggagttcac tttgtttatc gatattttgc aacttgcaaa      360

ccgaatctac ttcgtttgtt caacttgcca actcttctac tttggccact tggttgcagt      420

gtacccgtga caatgtgggc tagtgtctca tattttttgt atccagatac cgagtacacg      480

gaagcggctg tcaccaatgt actaaataac cactataact ggatcaaaaa ggagaatgta      540

tcgtacattg catacgtcta ttaccaatac gaaaacggag taaggcatat ctacctcaaa      600

aacttgcttg gatgctttgt tcattacttt gtcatgtcga tgacgtttgt tgtgatgttc      660

tactgcggat atgccacgtg gaaaactatg aatgaacaca aggatgtatc tgatagaact      720

cgagcgctac agaaacaact tttcaaagct ttagttcttc agacactcat cccaactatc      780

ttcatgtacg ccccaactgg agtcatgttc atcgcaccgt tttttgacgt gaatttgaat      840

gcaaacgcca atttcattgt gttttgctca tttctgtacc cgggactcga tccactcatt      900

ctgattttga tcattcgtga tttccgaaga acaatattca atttcttgtg tggaaagaaa      960

aacagtgttg atgaatcccg ctcgacaaca agagccaatt tgtctcaagt tccgacgatg     1020

accagcaagg tgtacgaccc cgagcagagg aagaggatga tcaccggccc ccagtggtgg     1080

gccaggtgca agcagatgaa cgtgctggac agcttcatca actactacga cagcgagaag     1140

cacgccgaga acgccgtgat cttcctgcac ggcaacgccg ctagcagcta cctgtggagg     1200

cacgtggtgc cccacatcga gcccgtggcc aggtgcatca tccccgatct gatcggcatg     1260

ggcaagagcg gcaagagcgg caacggcagc tacaggctgc tggaccacta caagtacctg     1320

accgcctggt tcgagctcct gaacctgccc aagaagatca tcttcgtggg ccacgactgg     1380

ggcgcctgcc tggccttcca ctacagctac gagcaccagg acaagatcaa ggccatcgtg     1440

cacgccgaga gcgtggtgga cgtgatcgag agctgggacg agtggccaga catcgaggag     1500

gacatcgccc tgatcaagag cgaggagggc gagaagatgg tgctggagaa caacttcttc     1560

gtggagacca tgctgcccag caagatcatg agaaagctgg agcccgagga gttcgccgcc     1620

tacctggagc ccttcaagga gaagggcgag gtgagaagac ccaccctgag ctggcccaga     1680

gagatccccc tggtgaaggg cggcaagccc gacgtggtgc agatcgtgag aaactacaac     1740

gcctacctga gagccagcga cgacctgccc aagatgttca tcgagagcga ccccggcttc     1800

ttcagcaacg ccatcgtgga gggcgccaag aagttcccca acaccgagtt cgtgaaggtg     1860

aagggcctgc acttcagcca ggaggacgcc cccgacgaga tgggcaagta catcaagagc     1920

ttcgtggaga gagtgctgaa gaacgagcag taa                                  1953


<210>  19
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRET construct

<400>  19

Met Ser Gly Glu Leu Trp Ile Thr Leu Val Asp Thr Ala Asp Ile Val 
1               5                   10                  15      


Gly Val Thr Leu Thr Phe Cys Val Asn Ile Val Leu Leu Gly Leu Leu 
            20                  25                  30          


Lys Thr Arg Gly Lys Asn Leu Gly Thr Tyr Lys Tyr Leu Met Ala Phe 
        35                  40                  45              


Phe Ser Val Phe Ser Ile Phe Tyr Ala Ile Ile Glu Phe Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asn Tyr Ser Thr Lys Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Val Ser Gly Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Thr Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro Thr Leu Leu Leu Trp Pro Leu Gly Cys Ser Val Pro Val Thr 
    130                 135                 140                 


Met Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Asn Val Leu Asn Asn His Tyr Asn Trp Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Val Arg His Ile Tyr Leu Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Met Phe Tyr Cys Gly Tyr 
    210                 215                 220                 


Ala Thr Trp Lys Thr Met Asn Glu His Lys Asp Val Ser Asp Arg Thr 
225                 230                 235                 240 


Arg Ala Leu Gln Lys Gln Leu Phe Lys Ala Leu Val Leu Gln Thr Leu 
                245                 250                 255     


Ile Pro Thr Ile Phe Met Tyr Ala Pro Thr Gly Val Met Phe Ile Ala 
            260                 265                 270         


Pro Phe Phe Asp Val Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe 
        275                 280                 285             


Cys Ser Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Leu Ile 
    290                 295                 300                 


Ile Arg Asp Phe Arg Arg Thr Ile Phe Asn Phe Leu Cys Gly Lys Lys 
305                 310                 315                 320 


Asn Ser Val Asp Glu Ser Arg Ser Thr Thr Arg Ala Asn Leu Ser Gln 
                325                 330                 335     


Val Pro Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
            340                 345                 350         


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
        355                 360                 365             


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
    370                 375                 380                 


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
385                 390                 395                 400 


Val Thr Thr Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
                405                 410                 415     


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
            420                 425                 430         


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
        435                 440                 445             


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
    450                 455                 460                 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
465                 470                 475                 480 


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
                485                 490                 495     


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
            500                 505                 510         


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
        515                 520                 525             


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
    530                 535                 540                 


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
545                 550                 555                 560 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
                565                 570                 575     


Tyr Lys 
        


<210>  20
<211>  1737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding BRET construct of SEQ ID NO:19

<400>  20
atgtcgggag aattgtggat taccctagtt gacacagcgg acattgtcgg cgtcaccctc       60

accttctgtg tcaacattgt tcttctcgga cttctgaaaa cacgtggaaa aaacttgggc      120

acttataaat atctcatggc gtttttctca gtattctcga ttttttacgc catcatcgag      180

ttcatattac gacctataat gcatattgag aacaccactt tctttttgat ctcaaggaaa      240

agattcaact actccaccaa acttggaaaa atcaactctg cgttttactg tgcttgtttt      300

gccaccagtt ttgttgtctc aggagttcac tttgtttatc gatattttgc aacttgcaaa      360

ccgaatctac ttcgtttgtt caacttgcca actcttctac tttggccact tggttgcagt      420

gtacccgtga caatgtgggc tagtgtctca tattttttgt atccagatac cgagtacacg      480

gaagcggctg tcaccaatgt actaaataac cactataact ggatcaaaaa ggagaatgta      540

tcgtacattg catacgtcta ttaccaatac gaaaacggag taaggcatat ctacctcaaa      600

aacttgcttg gatgctttgt tcattacttt gtcatgtcga tgacgtttgt tgtgatgttc      660

tactgcggat atgccacgtg gaaaactatg aatgaacaca aggatgtatc tgatagaact      720

cgagcgctac agaaacaact tttcaaagct ttagttcttc agacactcat cccaactatc      780

ttcatgtacg ccccaactgg agtcatgttc atcgcaccgt tttttgacgt gaatttgaat      840

gcaaacgcca atttcattgt gttttgctca tttctgtacc cgggactcga tccactcatt      900

ctgattttga tcattcgtga tttccgaaga acaatattca atttcttgtg tggaaagaaa      960

aacagtgttg atgaatcccg ctcgacaaca agagccaatt tgtctcaagt tccgacgatg     1020

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     1080

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     1140

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     1200

gtgaccaccc tgagctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag     1260

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     1320

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     1380

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     1440

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     1500

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     1560

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1620

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1680

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaa        1737


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  21
agtctagaat gtcgggagaa ttgtggatta                                        30


<210>  22
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  22
ggggacaagt ttgtacaaaa aagcaggctt catcacgtcg gaacttgag                   49


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  23
aaccatgtcg ggagaattgt g                                                 21


<210>  24
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  24
tgtagcgctc gcttgtacag ctcgtccat                                         29


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  25
gagctgtaca agcgagcgct acagaaacaa                                        30


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  26
cttgctggtc atcgtcggaa cttgagaca                                         29


<210>  27
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  27
caagttccga cgatgaccag caaggtgta                                         29


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  28
gttactgctc gttcttca                                                     18


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  29
gagctgtaca agcgagcgct acagaaacaa                                        30


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  30
gttactgctc gttcttca                                                     18


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  31
aaccatgtcg ggagaattgt g                                                 21


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  32
gttactgctc gttcttca                                                     18


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  33
aaccatgtcg ggagaattgt g                                                 21


<210>  34
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  34
ctgtagcgct cgctgctcgt tcttcag                                           27


<210>  35
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  35
aagaacgagc agcgagcgct acagaaaca                                         29


<210>  36
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  36
cttgctcacc atcgtcggaa cttgagaca                                         29


<210>  37
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  37
caagttccga cgatggtgag caagggcga                                         29


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  38
gttacttgta cagctcgtc                                                    19


<210>  39
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  39
aagaacgagc agcgagcgct acagaaaca                                         29


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  40
gttacttgta cagctcgtc                                                    19


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  41
aaccatgtcg ggagaattgt g                                                 21


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  42
gttacttgta cagctcgtc                                                    19


<210>  43
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  43
caccagtttt gttgtctcag gagtttattt tgtttatcga tattttgcaa ctt              53


<210>  44
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  44
aagttgcaaa atatcgataa acaaaataaa ctcctgagac aacaaaactg gtg              53


<210>  45
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCitrine derivative

<400>  45

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Gly Tyr Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Arg Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  46
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCFP derivative

<400>  46

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ile 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Arg Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  47
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized ORF encoding SEQ ID NO:45

<400>  47
atgtctaaag gtgaagaatt attcactggt gttgtcccaa ttttggttga attagatggt       60

gatgttaatg gtcacaaatt ttctgtctcc ggtgaaggtg aaggtgatgc tacttacggt      120

aaattgacct taaaatttat ttgtactact ggtaaattgc cagttccatg gccaacctta      180

gtcactactt taggttatgg tttgatgtgt tttgctagat acccagatca tatgaaacaa      240

catgactttt tcaagtctgc catgccagaa ggttatgttc aagaaagaac tatttttttc      300

aaagatgacg gtaactacaa gaccagagct gaagtcaagt ttgaaggtga taccttagtt      360

aatagaatcg aattaaaagg tattgatttt aaagaagatg gtaacatttt aggtcacaaa      420

ttggaataca actataactc tcacaatgtt tacatcatgg ctgacaaaca aaagaatggt      480

atcaaagtta acttcaaaat tagacacaac attgaagatg gttctgttca attagctgac      540

cattatcaac aaaatactcc aattggtgat ggtccagtct tgttaccaga caaccattac      600

ttatcctatc aatctagatt atccaaagat ccaaacgaaa agagagacca catggtcttg      660

ttagaatttg ttactgctgc tggtattacc catggtatgg atgaattgta caaataa         717


<210>  48
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized ORF encoding SEQ ID NO:46

<400>  48
atgtctaaag gtgaagaatt attcactggt gttgtcccaa ttttggttga attagatggt       60

gatgttaatg gtcacaaatt ttctgtctcc ggtgaaggtg aaggtgatgc tacttacggt      120

aaattgacct taaaatttat ttgtactact ggtaaattgc cagttccatg gccaacctta      180

gtcactactt taacttgggg tgttcaatgt ttttctagat acccagatca tatgaaacaa      240

catgactttt tcaagtctgc catgccagaa ggttatgttc aagaaagaac tatttttttc      300

aaagatgacg gtaactacaa gaccagagct gaagtcaagt ttgaaggtga taccttagtt      360

aatagaatcg aattaaaagg tattgatttt aaagaagatg gtaacatttt aggtcacaaa      420

ttggaataca tttataactc tcacaatgtt tacatcactg ctgacaaaca aaagaatggt      480

atcaaagcta acttcaaaat tagacacaac attgaagatg gttctgttca attagctgac      540

cattatcaac aaaatactcc aattggtgat ggtccagtct tgttaccaga caaccattac      600

ttatccactc aatctagatt atccaaagat ccaaacgaaa agagagacca catggtcttg      660

ttagaatttg ttactgctgc tggtattacc catggtatgg atgaattgta caaataa         717


<210>  49
<211>  2448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding FRET construct

<400>  49
atgtcgggag aattgtggat taccctagtt gacacagcgg acattgtcgg cgtcaccctc       60

accttctgtg tcaacattgt tcttctcgga cttctgaaaa cacgtggaaa aaacttgggc      120

acttataaat atctcatggc gtttttctca gtattctcga ttttttacgc catcatcgag      180

ttcatattac gacctataat gcatattgag aacaccactt tctttttgat ctcaaggaaa      240

agattcaact actccaccaa acttggaaaa atcaactctg cgttttactg tgcttgtttt      300

gccaccagtt ttgttgtctc aggagttcac tttgtttatc gatattttgc aacttgcaaa      360

ccgaatctac ttcgtttgtt caacttgcca actcttctac tttggccact tggttgcagt      420

gtacccgtga caatgtgggc tagtgtctca tattttttgt atccagatac cgagtacacg      480

gaagcggctg tcaccaatgt actaaataac cactataact ggatcaaaaa ggagaatgta      540

tcgtacattg catacgtcta ttaccaatac gaaaacggag taaggcatat ctacctcaaa      600

aacttgcttg gatgctttgt tcattacttt gtcatgtcga tgacgtttgt tgtgatgttc      660

tactgcggat atgccacgtg gaaaactatg aatgaacaca aggatgtatc tgatagaact      720

atgtctaaag gtgaagaatt attcactggt gttgtcccaa ttttggttga attagatggt      780

gatgttaatg gtcacaaatt ttctgtctcc ggtgaaggtg aaggtgatgc tacttacggt      840

aaattgacct taaaatttat ttgtactact ggtaaattgc cagttccatg gccaacctta      900

gtcactactt taacttgggg tgttcaatgt ttttctagat acccagatca tatgaaacaa      960

catgactttt tcaagtctgc catgccagaa ggttatgttc aagaaagaac tatttttttc     1020

aaagatgacg gtaactacaa gaccagagct gaagtcaagt ttgaaggtga taccttagtt     1080

aatagaatcg aattaaaagg tattgatttt aaagaagatg gtaacatttt aggtcacaaa     1140

ttggaataca tttataactc tcacaatgtt tacatcactg ctgacaaaca aaagaatggt     1200

atcaaagcta acttcaaaat tagacacaac attgaagatg gttctgttca attagctgac     1260

cattatcaac aaaatactcc aattggtgat ggtccagtct tgttaccaga caaccattac     1320

ttatccactc aatctagatt atccaaagat ccaaacgaaa agagagacca catggtcttg     1380

ttagaatttg ttactgctgc tggtattacc catggtatgg atgaattgta caaacgagcg     1440

ctacagaaac aacttttcaa agctttagtt cttcagacac tcatcccaac tatcttcatg     1500

tacgccccaa ctggagtcat gttcatcgca ccgttttttg acgtgaattt gaatgcaaac     1560

gccaatttca ttgtgttttg ctcatttctg tacccgggac tcgatccact cattctgatt     1620

ttgatcattc gtgatttccg aagaacaata ttcaatttct tgtgtggaaa gaaaaacagt     1680

gttgatgaat cccgctcgac aacaagagcc aatttgtctc aagttccgac gatgtctaaa     1740

ggtgaagaat tattcactgg tgttgtccca attttggttg aattagatgg tgatgttaat     1800

ggtcacaaat tttctgtctc cggtgaaggt gaaggtgatg ctacttacgg taaattgacc     1860

ttaaaattta tttgtactac tggtaaattg ccagttccat ggccaacctt agtcactact     1920

ttaggttatg gtttgatgtg ttttgctaga tacccagatc atatgaaaca acatgacttt     1980

ttcaagtctg ccatgccaga aggttatgtt caagaaagaa ctattttttt caaagatgac     2040

ggtaactaca agaccagagc tgaagtcaag tttgaaggtg ataccttagt taatagaatc     2100

gaattaaaag gtattgattt taaagaagat ggtaacattt taggtcacaa attggaatac     2160

aactataact ctcacaatgt ttacatcatg gctgacaaac aaaagaatgg tatcaaagtt     2220

aacttcaaaa ttagacacaa cattgaagat ggttctgttc aattagctga ccattatcaa     2280

caaaatactc caattggtga tggtccagtc ttgttaccag acaaccatta cttatcctat     2340

caatctagat tatccaaaga tccaaacgaa aagagagacc acatggtctt gttagaattt     2400

gttactgctg ctggtattac ccatggtatg gatgaattgt acaaataa                  2448


<210>  50
<211>  815
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRETConstruct

<400>  50

Met Ser Gly Glu Leu Trp Ile Thr Leu Val Asp Thr Ala Asp Ile Val 
1               5                   10                  15      


Gly Val Thr Leu Thr Phe Cys Val Asn Ile Val Leu Leu Gly Leu Leu 
            20                  25                  30          


Lys Thr Arg Gly Lys Asn Leu Gly Thr Tyr Lys Tyr Leu Met Ala Phe 
        35                  40                  45              


Phe Ser Val Phe Ser Ile Phe Tyr Ala Ile Ile Glu Phe Ile Leu Arg 
    50                  55                  60                  


Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg Lys 
65                  70                  75                  80  


Arg Phe Asn Tyr Ser Thr Lys Leu Gly Lys Ile Asn Ser Ala Phe Tyr 
                85                  90                  95      


Cys Ala Cys Phe Ala Thr Ser Phe Val Val Ser Gly Val His Phe Val 
            100                 105                 110         


Tyr Arg Tyr Phe Ala Thr Cys Lys Pro Asn Leu Leu Arg Leu Phe Asn 
        115                 120                 125             


Leu Pro Thr Leu Leu Leu Trp Pro Leu Gly Cys Ser Val Pro Val Thr 
    130                 135                 140                 


Met Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr Thr 
145                 150                 155                 160 


Glu Ala Ala Val Thr Asn Val Leu Asn Asn His Tyr Asn Trp Ile Lys 
                165                 170                 175     


Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu Asn 
            180                 185                 190         


Gly Val Arg His Ile Tyr Leu Lys Asn Leu Leu Gly Cys Phe Val His 
        195                 200                 205             


Tyr Phe Val Met Ser Met Thr Phe Val Val Met Phe Tyr Cys Gly Tyr 
    210                 215                 220                 


Ala Thr Trp Lys Thr Met Asn Glu His Lys Asp Val Ser Asp Arg Thr 
225                 230                 235                 240 


Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
                245                 250                 255     


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            260                 265                 270         


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        275                 280                 285             


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    290                 295                 300                 


Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
305                 310                 315                 320 


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                325                 330                 335     


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            340                 345                 350         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        355                 360                 365             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ile 
    370                 375                 380                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
385                 390                 395                 400 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                405                 410                 415     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            420                 425                 430         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Arg Leu Ser 
        435                 440                 445             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    450                 455                 460                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Arg Ala 
465                 470                 475                 480 


Leu Gln Lys Gln Leu Phe Lys Ala Leu Val Leu Gln Thr Leu Ile Pro 
                485                 490                 495     


Thr Ile Phe Met Tyr Ala Pro Thr Gly Val Met Phe Ile Ala Pro Phe 
            500                 505                 510         


Phe Asp Val Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe Cys Ser 
        515                 520                 525             


Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Leu Ile Ile Arg 
    530                 535                 540                 


Asp Phe Arg Arg Thr Ile Phe Asn Phe Leu Cys Gly Lys Lys Asn Ser 
545                 550                 555                 560 


Val Asp Glu Ser Arg Ser Thr Thr Arg Ala Asn Leu Ser Gln Val Pro 
                565                 570                 575     


Thr Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
            580                 585                 590         


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
        595                 600                 605             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
    610                 615                 620                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
625                 630                 635                 640 


Leu Gly Tyr Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
                645                 650                 655     


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
            660                 665                 670         


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        675                 680                 685             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    690                 695                 700                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
705                 710                 715                 720 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
                725                 730                 735     


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
            740                 745                 750         


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
        755                 760                 765             


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Arg Leu 
    770                 775                 780                 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
785                 790                 795                 800 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
                805                 810                 815 


<210>  51
<211>  2694
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding BRET construct

<400>  51
atgggttctg gtcaattatg gttggcttta gttgatgctg cagatatggt tggttttact       60

ttgacaatct caattaatat cattttgtta ggtttgatta gaactagagg taaaaccttg      120

ggtacttaca agtacttgat gtctttcttt tctttctttt ctattttcta tgcaatcgtt      180

gaatctatct tgagaccaat catgcatatc gaaaacacta catttttctt aatctccaga      240

aagagattcg attacagtac tagattgggt aaaattaatt cagctttcta ctgtgcttgt      300

ttcgcaacat ccttcgtttt gagtgcagtt catttcgttt acagatactt cgctgcttgt      360

aagcctaatt tgttgagatt gtttaactta cctcatttgt tattgtggcc attgatgtgt      420

tcaattcctg ttactgcttg ggcatctgtt tcatactttt tgtacccaga tacagaatat      480

accgaagctg cagttaccta tgttttgaag actcattacg aagttattaa aaaggaaaac      540

gtttcttaca ttgcttacgt ttactaccaa tacgaaaacg gtgaaagaca tatctatatt      600

aaaaacttat tgggttgttt cgttcattac ttcgttatgt ctatgacatt cgttgttgtt      660

ttctattgtg gtttctcaac ttggtggaca attagagaac atagaggtgc ttccgataga      720

acaatggtta gtaagggtga agaattattc accggtgttg ttccaatttt ggttgaatta      780

gatggtgacg ttaatggtca taaattttcc gttagtggtg aaggtgaagg tgacgcaaca      840

tacggtaaat tgaccttgaa gtttatttgt accactggta aattgccagt tccttggcca      900

accttggtta caaccttaac ttatggtgtt caatgttttt ccagataccc tgatcatatg      960

aagcaacatg atttctttaa gagtgctatg ccagaaggtt acgttcaaga aagaacaatt     1020

ttctttaagg atgatggtaa ctacaagact agagcagagg ttaagttcga aggtgacaca     1080

ttggttaaca gaatcgaatt gaagggtatc gatttcaagg aagatggtaa catcttgggt     1140

cataagttgg aatacaatta caactcccat aacgtttaca tcatggctga taagcaaaag     1200

aatggtatta aagttaactt caagatcaga cataacatcg aagatggttc agttcaattg     1260

gcagatcatt accaacaaaa cacccctatt ggtgacggtc ctgttttgtt gccagataac     1320

cattacttat caactcaatc cgctttgagt aaggatccaa acgaaaagag agatcatatg     1380

gttttgttgg aattcgttac tgctgcaggt atcacattgg gtatggatga attgtacaag     1440

agacatttgc atagacaatt gtttaaagct ttggttttcc aaaccttggt tccatcaatt     1500

tttatgtaca tccctactgg tgttatgttc atcgcaccat ttttcgatat caatttgaac     1560

gctaacgcaa acttcatcgt tttctgttca tttttgtatc ctggtttgga tccattgatc     1620

ttgattttca ttatcagaga attcagagtt acaattttaa acattattcg tggtaatgaa     1680

cgtggtaacg ctgttggtga agcatactct acctcaagaa ttaaatcttc acaaccagct     1740

gcagttaatt tgtctggtat gacatcaaag gtttacgatc ctgaacaaag aaaaagaatg     1800

attaccggtc cacaatggtg ggctcgttgt aagcaaatga acgttttgga ttctttcatt     1860

aactactacg attcagaaaa gcatgctgaa aacgctgtta ttttcttgca tggtaacgct     1920

gcatccagtt atttgtggag acatgttgtt cctcatattg aaccagttgc tagatgtatc     1980

atccctgatt tgatcggtat gggtaaatct ggtaaatctg gtaacggttc ttacagattg     2040

ttggatcatt acaagtactt aactgcatgg ttcgaattgt tgaatttgcc aaagaaaatt     2100

atcttcgttg gtcatgattg gggtgcttgt ttggcatttc attactctta cgaacatcaa     2160

gataaaatta aggctatcgt tcatgcagaa tccgttgttg atgttattga aagttgggat     2220

gaatggccag atatcgaaga agatatcgct ttaattaagt ccgaagaagg tgaaaagatg     2280

gttttggaaa acaacttttt cgttgaaact atgttgccta gtaagatcat gagaaagttg     2340

gaacctgaag aatttgctgc atatttggaa ccattcaaag aaaagggtga agttagaaga     2400

cctacattat cttggcctag agaaattcca ttggttaaag gtggtaaacc agatgttgtt     2460

caaatcgtta gaaactacaa cgcttactta agagcatctg atgatttgcc aaagatgttc     2520

atcgaatctg atcctggttt cttttctaat gctattgttg aaggtgctaa gaaattccct     2580

aacacagaat tcgttaaggt taagggtttg catttctctc aagaagatgc tccagatgaa     2640

atgggtaaat acatcaagtc atttgttgaa agagttttga aaaatgaaca ataa           2694


<210>  52
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRET Construct

<400>  52

Met Gly Ser Gly Gln Leu Trp Leu Ala Leu Val Asp Ala Ala Asp Met 
1               5                   10                  15      


Val Gly Phe Thr Leu Thr Ile Ser Ile Asn Ile Ile Leu Leu Gly Leu 
            20                  25                  30          


Ile Arg Thr Arg Gly Lys Thr Leu Gly Thr Tyr Lys Tyr Leu Met Ser 
        35                  40                  45              


Phe Phe Ser Phe Phe Ser Ile Phe Tyr Ala Ile Val Glu Ser Ile Leu 
    50                  55                  60                  


Arg Pro Ile Met His Ile Glu Asn Thr Thr Phe Phe Leu Ile Ser Arg 
65                  70                  75                  80  


Lys Arg Phe Asp Tyr Ser Thr Arg Leu Gly Lys Ile Asn Ser Ala Phe 
                85                  90                  95      


Tyr Cys Ala Cys Phe Ala Thr Ser Phe Val Leu Ser Ala Val His Phe 
            100                 105                 110         


Val Tyr Arg Tyr Phe Ala Ala Cys Lys Pro Asn Leu Leu Arg Leu Phe 
        115                 120                 125             


Asn Leu Pro His Leu Leu Leu Trp Pro Leu Met Cys Ser Ile Pro Val 
    130                 135                 140                 


Thr Ala Trp Ala Ser Val Ser Tyr Phe Leu Tyr Pro Asp Thr Glu Tyr 
145                 150                 155                 160 


Thr Glu Ala Ala Val Thr Tyr Val Leu Lys Thr His Tyr Glu Val Ile 
                165                 170                 175     


Lys Lys Glu Asn Val Ser Tyr Ile Ala Tyr Val Tyr Tyr Gln Tyr Glu 
            180                 185                 190         


Asn Gly Glu Arg His Ile Tyr Ile Lys Asn Leu Leu Gly Cys Phe Val 
        195                 200                 205             


His Tyr Phe Val Met Ser Met Thr Phe Val Val Val Phe Tyr Cys Gly 
    210                 215                 220                 


Phe Ser Thr Trp Trp Thr Ile Arg Glu His Arg Gly Ala Ser Asp Arg 
225                 230                 235                 240 


Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                245                 250                 255     


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
            260                 265                 270         


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        275                 280                 285             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    290                 295                 300                 


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
305                 310                 315                 320 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                325                 330                 335     


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            340                 345                 350         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        355                 360                 365             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
    370                 375                 380                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
385                 390                 395                 400 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
                405                 410                 415     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            420                 425                 430         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        435                 440                 445             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
    450                 455                 460                 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
465                 470                 475                 480 


Arg His Leu His Arg Gln Leu Phe Lys Ala Leu Val Phe Gln Thr Leu 
                485                 490                 495     


Val Pro Ser Ile Phe Met Tyr Ile Pro Thr Gly Val Met Phe Ile Ala 
            500                 505                 510         


Pro Phe Phe Asp Ile Asn Leu Asn Ala Asn Ala Asn Phe Ile Val Phe 
        515                 520                 525             


Cys Ser Phe Leu Tyr Pro Gly Leu Asp Pro Leu Ile Leu Ile Phe Ile 
    530                 535                 540                 


Ile Arg Glu Phe Arg Val Thr Ile Leu Asn Ile Ile Arg Gly Asn Glu 
545                 550                 555                 560 


Arg Gly Asn Ala Val Gly Glu Ala Tyr Ser Thr Ser Arg Ile Lys Ser 
                565                 570                 575     


Ser Gln Pro Ala Ala Val Asn Leu Ser Gly Met Thr Ser Lys Val Tyr 
            580                 585                 590         


Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala 
        595                 600                 605             


Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp 
    610                 615                 620                 


Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala 
625                 630                 635                 640 


Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro Val 
                645                 650                 655     


Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys 
            660                 665                 670         


Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr 
        675                 680                 685             


Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly 
    690                 695                 700                 


His Asp Trp Gly Ala Cys Leu Ala Phe His Tyr Ser Tyr Glu His Gln 
705                 710                 715                 720 


Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser Val Val Asp Val Ile 
                725                 730                 735     


Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile 
            740                 745                 750         


Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn Phe Phe Val 
        755                 760                 765             


Glu Thr Met Leu Pro Ser Lys Ile Met Arg Lys Leu Glu Pro Glu Glu 
    770                 775                 780                 


Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu Val Arg Arg 
785                 790                 795                 800 


Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys Gly Gly Lys 
                805                 810                 815     


Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg Ala 
            820                 825                 830         


Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser Asp Pro Gly Phe Phe 
        835                 840                 845             


Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu Phe 
    850                 855                 860                 


Val Lys Val Lys Gly Leu His Phe Ser Gln Glu Asp Ala Pro Asp Glu 
865                 870                 875                 880 


Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn Glu 
                885                 890                 895     


Gln 
    


<210>  53
<211>  2673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORF encoding 2A adrenergic receptor-BRET construct

<400>  53
atgggttatc cttacgatgt tccagattat gcttcaatgg gttccttaca accagatgct       60

ggtaattctt catggaacgg tacagaagct ccaggtggtg gtaccagagc aactccatac      120

tcattgcaag ttacattgac cttagtttgt ttggctggtt tgttgatgtt gtttactgtt      180

ttcggtaacg ttttggttat tatcgcagtt tttacatcta gagctttgaa ggcaccacaa      240

aatttgttct tagttagttt ggcttctgca gatatcttgg ttgctacatt agttattcct      300

ttttctttgg caaacgaagt tatgggttat tggtacttcg gtaaagtttg gtgtgaaata      360

tatttggctt tggatgtttt gttttgtact tccagtatcg ttcatttgtg tgctatctct      420

ttggatagat actggtcaat cacacaagca atcgaataca atttgaagag aaccccaaga      480

agaattaaag ctatcatcgt tactgtttgg gttatttccg cagttattag ttttccacct      540

ttgatttcca ttgaaaagaa aggtgctggt ggtggtcaac aacctgcaga accaagttgt      600

aagattaatg atcaaaagtg gtatgttatt tcttcatcca ttggttcttt ctttgctcca      660

tgtttgatca tgatcttggt ttacgttaga atctatcaaa tcgctaagag aagaactaga      720

gttccacctt ctagaagagg tccagatgca atggtttcaa aaggtgaaga attgtttact      780

ggtgttgttc ctattttggt tgaattagat ggtgacgtta atggtcataa gtttagtgtt      840

tctggtgaag gtgaaggtga cgctacatac ggtaaattga ccttgaagtt tatttgtact      900

actggtaaat tgccagttcc ttggccaacc ttggttacca ctttaactta tggtgttcaa      960

tgtttttcca gatacccaga tcatatgaag caacatgatt tctttaagag tgctatgcct     1020

gaaggttacg ttcaagaaag aactattttc tttaaggatg atggtaacta caagacaaga     1080

gcagaggtta agtttgaagg tgacaccttg gttaacagaa tcgaattgaa gggtatcgat     1140

ttcaaggaag atggtaacat cttgggtcat aagttggaat acaattacaa ctcccataac     1200

gtttacatca tggctgataa gcaaaagaat ggtattaaag ttaacttcaa gatcagacat     1260

aacatcgaag atggttcagt tcaattggca gatcattacc aacaaaacac accaattggt     1320

gacggtcctg ttttgttacc agataaccat tacttgtcaa cccaatccgc tttaagtaaa     1380

gatcctaacg aaaagagaga tcatatggtt ttgttggaat tcgttactgc tgcaggtatc     1440

acattgggta tggatgaatt gtacaagaga tggagaggta gacaaaacag agaaaagaga     1500

ttcactttcg ttttggctgt tgttattggt gttttcgttg tttgttggtt cccatttttc     1560

tttacttaca cattgatcgc agttggttgt cctgttccat ctcaattgtt caacttcttt     1620

ttctggttcg gttactgtaa cagttctttg aacccagtta tatatactat tttcaatcat     1680

gatttcagaa gagcttttaa aaagattttg tgtagaggtg acagaaagag aatcgttatg     1740

acctctaagg tttacgatcc agaacaaaga aagagaatga ttactggtcc tcaatggtgg     1800

gcacgttgta agcaaatgaa cgttttggat tcttttatta actactacga ttcagaaaag     1860

catgctgaaa acgcagttat tttcttgcat ggtaacgctg catcatccta tttgtggaga     1920

catgttgttc ctcatattga accagttgct agatgtatca tcccagattt gatcggtatg     1980

ggtaaatctg gtaaatctgg taacggttct tacagattgt tggatcatta caagtacttg     2040

acagcatggt tcgaattgtt gaatttgcca aagaaaatta tcttcgttgg tcatgattgg     2100

ggtgcttgtt tggcattcca ttactcatac gaacatcaag ataaaattaa ggctatcgtt     2160

catgcagaat ccgttgttga tgttattgaa agttgggatg aatggccaga tatcgaagaa     2220

gatatcgctt taattaagtc tgaagaaggt gaaaagatgg ttttggaaaa caactttttc     2280

gttgaaacca tgttgccttc aaagatcatg agaaagttgg aaccagaaga attcgctgca     2340

tatttggaac cttttaaaga aaagggtgaa gttagaagac caactttgtc atggcctaga     2400

gaaattccat tagttaaagg tggtaaacct gatgttgttc aaatcgttag aaactacaac     2460

gcttacttga gagcatctga tgatttgcct aagatgttca tcgaatccga tccaggtttc     2520

ttttctaatg ctattgttga aggtgctaag aaattcccaa acactgaatt cgttaaggtt     2580

aagggtttgc atttctctca agaagatgct cctgatgaaa tgggtaaata catcaagtca     2640

ttcgttgaaa gagttttgaa aaatgaacaa taa                                  2673


<210>  54
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A adrenergic receptor-BRET construct

<400>  54

Met Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Met Gly Ser Leu 
1               5                   10                  15      


Gln Pro Asp Ala Gly Asn Ser Ser Trp Asn Gly Thr Glu Ala Pro Gly 
            20                  25                  30          


Gly Gly Thr Arg Ala Thr Pro Tyr Ser Leu Gln Val Thr Leu Thr Leu 
        35                  40                  45              


Val Cys Leu Ala Gly Leu Leu Met Leu Phe Thr Val Phe Gly Asn Val 
    50                  55                  60                  


Leu Val Ile Ile Ala Val Phe Thr Ser Arg Ala Leu Lys Ala Pro Gln 
65                  70                  75                  80  


Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile Leu Val Ala Thr 
                85                  90                  95      


Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met Gly Tyr Trp Tyr 
            100                 105                 110         


Phe Gly Lys Val Trp Cys Glu Ile Tyr Leu Ala Leu Asp Val Leu Phe 
        115                 120                 125             


Cys Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr 
    130                 135                 140                 


Trp Ser Ile Thr Gln Ala Ile Glu Tyr Asn Leu Lys Arg Thr Pro Arg 
145                 150                 155                 160 


Arg Ile Lys Ala Ile Ile Val Thr Val Trp Val Ile Ser Ala Val Ile 
                165                 170                 175     


Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly Ala Gly Gly Gly 
            180                 185                 190         


Gln Gln Pro Ala Glu Pro Ser Cys Lys Ile Asn Asp Gln Lys Trp Tyr 
        195                 200                 205             


Val Ile Ser Ser Ser Ile Gly Ser Phe Phe Ala Pro Cys Leu Ile Met 
    210                 215                 220                 


Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys Arg Arg Thr Arg 
225                 230                 235                 240 


Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Met Val Ser Lys Gly Glu 
                245                 250                 255     


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            260                 265                 270         


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        275                 280                 285             


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    290                 295                 300                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
305                 310                 315                 320 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                325                 330                 335     


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
            340                 345                 350         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        355                 360                 365             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    370                 375                 380                 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
385                 390                 395                 400 


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
                405                 410                 415     


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            420                 425                 430         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        435                 440                 445             


Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    450                 455                 460                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
465                 470                 475                 480 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Arg Trp Arg Gly Arg Gln Asn 
                485                 490                 495     


Arg Glu Lys Arg Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe 
            500                 505                 510         


Val Val Cys Trp Phe Pro Phe Phe Phe Thr Tyr Thr Leu Ile Ala Val 
        515                 520                 525             


Gly Cys Pro Val Pro Ser Gln Leu Phe Asn Phe Phe Phe Trp Phe Gly 
    530                 535                 540                 


Tyr Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His 
545                 550                 555                 560 


Asp Phe Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys 
                565                 570                 575     


Arg Ile Val Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg 
            580                 585                 590         


Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val 
        595                 600                 605             


Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn 
    610                 615                 620                 


Ala Val Ile Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg 
625                 630                 635                 640 


His Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp 
                645                 650                 655     


Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg 
            660                 665                 670         


Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn 
        675                 680                 685             


Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu 
    690                 695                 700                 


Ala Phe His Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val 
705                 710                 715                 720 


His Ala Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro 
                725                 730                 735     


Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys 
            740                 745                 750         


Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys 
        755                 760                 765             


Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro 
    770                 775                 780                 


Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg 
785                 790                 795                 800 


Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val 
                805                 810                 815     


Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met 
            820                 825                 830         


Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly 
        835                 840                 845             


Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His 
    850                 855                 860                 


Phe Ser Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser 
865                 870                 875                 880 


Phe Val Glu Arg Val Leu Lys Asn Glu Gln 
                885                 890 


<210>  55
<211>  1389
<212>  DNA
<213>  Mus musculus

<400>  55
atgggctacc catacgacgt cccagactac gccagcatgg gctcactgca gccggatgcc       60

ggcaacagca gctggaacgg gaccgaagcg cccggaggcg gcacccgagc caccccttac      120

tccctgcagg tgacactgac gctggtttgc ctggctggcc tgctcatgct gttcacagta      180

tttggcaacg tgctggttat tatcgcggtg ttcaccagtc gcgcgctcaa agctccccaa      240

aacctcttcc tggtgtccct ggcctcagcg gacatcctgg tggccacgct ggtcattccc      300

ttttctttgg ccaacgaggt tatgggttac tggtactttg gtaaggtgtg gtgtgagatc      360

tatttggctc tcgacgtgct cttttgcacg tcgtccatag tgcacctgtg cgccatcagc      420

cttgaccgct actggtccat cacgcaggcc atcgagtaca acctgaagcg cacgccgcgt      480

cgcatcaagg ccatcattgt caccgtgtgg gtcatctcgg ctgtcatctc cttcccgcca      540

ctcatctcca tagagaagaa gggcgctggc ggcgggcagc agccggccga gccaagctgc      600

aagatcaacg accagaagtg gtatgtcatc tcctcgtcca tcggttcctt cttcgcgcct      660

tgcctcatca tgatcctggt ctacgtgcgt atttaccaga tcgccaagcg tcgcacccgg      720

tgcctcccag ccgccggggt ccggacgcct cgttccgcgc cgccgggggg cgccgatcgc      780

aggcccaacg ggctgggccc ggagcgcggc gcgggtccca cgggcgctga ggcggagccg      840

ctgcccaccc agcttaacgg tgccccgggg gagcccgcgc ccgccgggcc ccgcgatggg      900

gatgcgctgg acctagagga gagttcgtcg tccgagcacg ccgagcggcc cccggggccc      960

cgcagacccg accgcggccc ccgagccaag ggcaagaccc gggcgagtca ggtgaagccg     1020

ggggacagtc tgccgcggcg cgggcccggg gccgcggggc cgggggcttc ggggtccggg     1080

cacggagagg agcgcggcgg gggcgccaaa gcgtcgcgct ggcgcgggag gcaaaaccgg     1140

gagaaacgct tcacgttcgt gctggcggtg gtgatcggcg tgttcgtggt gtgttggttt     1200

ccgttctttt tcacctacac gctcatagcg gtcggctgcc cggtgcccag ccagctcttc     1260

aacttcttct tctggttcgg ctactgcaac agctcgctga accctgttat ctacaccatc     1320

ttcaaccacg acttccgacg cgccttcaag aagatcctct gccgtgggga cagaaaacgc     1380

atcgtgtga                                                             1389


<210>  56
<211>  462
<212>  PRT
<213>  Mus musculus

<400>  56

Met Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Met Gly Ser Leu 
1               5                   10                  15      


Gln Pro Asp Ala Gly Asn Ser Ser Trp Asn Gly Thr Glu Ala Pro Gly 
            20                  25                  30          


Gly Gly Thr Arg Ala Thr Pro Tyr Ser Leu Gln Val Thr Leu Thr Leu 
        35                  40                  45              


Val Cys Leu Ala Gly Leu Leu Met Leu Phe Thr Val Phe Gly Asn Val 
    50                  55                  60                  


Leu Val Ile Ile Ala Val Phe Thr Ser Arg Ala Leu Lys Ala Pro Gln 
65                  70                  75                  80  


Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile Leu Val Ala Thr 
                85                  90                  95      


Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met Gly Tyr Trp Tyr 
            100                 105                 110         


Phe Gly Lys Val Trp Cys Glu Ile Tyr Leu Ala Leu Asp Val Leu Phe 
        115                 120                 125             


Cys Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr 
    130                 135                 140                 


Trp Ser Ile Thr Gln Ala Ile Glu Tyr Asn Leu Lys Arg Thr Pro Arg 
145                 150                 155                 160 


Arg Ile Lys Ala Ile Ile Val Thr Val Trp Val Ile Ser Ala Val Ile 
                165                 170                 175     


Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly Ala Gly Gly Gly 
            180                 185                 190         


Gln Gln Pro Ala Glu Pro Ser Cys Lys Ile Asn Asp Gln Lys Trp Tyr 
        195                 200                 205             


Val Ile Ser Ser Ser Ile Gly Ser Phe Phe Ala Pro Cys Leu Ile Met 
    210                 215                 220                 


Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys Arg Arg Thr Arg 
225                 230                 235                 240 


Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Cys Ser Ala Pro Pro Gly 
                245                 250                 255     


Gly Ala Asp Arg Arg Pro Asn Gly Leu Gly Pro Glu Arg Gly Ala Gly 
            260                 265                 270         


Pro Thr Gly Ala Glu Ala Glu Pro Leu Pro Thr Gln Leu Asn Gly Ala 
        275                 280                 285             


Pro Gly Glu Pro Ala Pro Ala Gly Pro Arg Asp Gly Asp Ala Leu Asp 
    290                 295                 300                 


Leu Glu Glu Ser Ser Ser Ser Glu His Ala Glu Arg Pro Pro Gly Pro 
305                 310                 315                 320 


Arg Arg Pro Asp Arg Gly Pro Arg Ala Lys Gly Lys Thr Arg Ala Ser 
                325                 330                 335     


Gln Val Lys Pro Gly Asp Ser Leu Pro Arg Arg Gly Pro Gly Ala Ala 
            340                 345                 350         


Gly Pro Gly Ala Ser Gly Ser Gly His Gly Glu Glu Arg Gly Gly Gly 
        355                 360                 365             


Ala Lys Ala Ser Arg Trp Arg Gly Arg Gln Asn Arg Glu Lys Arg Phe 
    370                 375                 380                 


Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val Val Cys Trp Phe 
385                 390                 395                 400 


Pro Phe Phe Phe Thr Tyr Thr Leu Ile Ala Val Gly Cys Pro Val Pro 
                405                 410                 415     


Ser Gln Leu Phe Asn Phe Phe Phe Trp Phe Gly Tyr Cys Asn Ser Ser 
            420                 425                 430         


Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His Asp Phe Arg Arg Ala 
        435                 440                 445             


Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg Ile Val 
    450                 455                 460         


