                         SEQUENCE LISTING

<110>  Regents of the University of Colorado
       Dinarello, Charles A.
       Lewis, Eli
       Shapiro, Leland
 
<120>  COMPOSITIONS AND METHODS OF USE FOR ALPHA-1 ANTITRYPSIN HAVING NO
        SIGNIFICANT SERINE PROTEASE INHIBITOR ACTIVITY

<130>  79487-376018

<140>  12/322,201
<141>  2009-01-30

<150>  12/177,798
<151>  2008-07-22

<150>  12/106,052
<151>  2008-04-18

<150>  60/913,174
<151>  2007-04-20

<150>  11/915,521
<151>  2007-12-04

<150>  PCT/US06/22436
<151>  2006-06-07

<150>  60/687,850
<151>  2005-06-07

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  1

Phe Val Phe Leu Met 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  2

Phe Val Phe Ala Met 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  3

Phe Val Ala Leu Met 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  4

Phe Val Phe Leu Ala 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  5

Phe Leu Val Phe Ile 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  6

Phe Leu Met Ile Ile 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  7

Phe Leu Phe Val Leu 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  8

Phe Leu Phe Val Val 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  9

Phe Leu Phe Leu Ile 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Phe Leu Phe Phe Ile 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  11

Phe Leu Met Phe Ile 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  12

Phe Met Leu Leu Ile 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Phe Ile Ile Met Ile 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  14

Phe Leu Phe Cys Ile 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  15

Phe Leu Phe Ala Val 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  16

Phe Val Tyr Leu Ile 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  17

Phe Ala Phe Leu Met 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  18

Ala Val Phe Leu Met 
1               5   


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Ser Ser Val Ser Trp Gly Ile Leu 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Leu Ala Gly Leu Cys Cys Leu Val Pro 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Ser Leu Ala Glu Asp Pro Gln Gly Asp 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Gln Asp His Pro Thr Phe Asn Lys Ile 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Tyr Arg Gln Leu Ala His Gln Ser Asn 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Ala Thr Ala Phe Ala Met Leu Ser Leu 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Thr Lys Ala Asp Thr His Asp Glu Ile 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Tyr His Ser Glu Ala Phe Thr Val Asn 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  37

Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Arg Asp Thr Val Phe Ala Leu Val Asn 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  41

Pro Phe Glu Val Lys Asp Thr Glu Glu Glu 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Phe His Val Asp Gln Val Thr Thr Val 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Val Pro Met Met Lys Arg Leu Gly Met 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Phe Asn Ile Gln His Cys Lys Lys Leu Ser 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Trp Val Leu Leu Met Lys Tyr Leu Gly 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  46

Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Gly Lys Leu Gln His Leu Glu Asn Glu 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  48

Leu Thr His Asp Ile Ile Thr Lys Phe Leu 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  50

His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  51

Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Ile Thr Lys Val Phe Ser Asn Gly Ala 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Leu Ser Gly Val Thr Glu Glu Ala Pro 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Lys Leu Ser Lys Ala Val His Lys Ala 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  55

Val Leu Thr Ile Asp Glu Lys Gly Thr Glu 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Ala Gly Ala Met Phe Leu Glu Ala Ile 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  57

Pro Met Ser Ile Pro Pro Glu Val Lys Phe 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  58

Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Asn Thr Lys Ser Pro Leu Phe Met Gly 
1               5                   10  


<210>  60
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  60

Lys Val Val Asn Pro Thr Gln Lys 
1               5               


<210>  61
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  61

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
actcctccgt accctcaacc                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
gcattgccca ggtatttcat                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
actgtcaact tcggggacac                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
catgcctaaa cgcttcatca                                                   20


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
ctccatgagc tttgtacaag g                                                 21


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  67
tgctgatgta ccagttgggg                                                   20


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  68
catttgcatc ctcctggttt ctga                                              24


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
gagtgagttt tccccttccg tgtg                                              24


<210>  70
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
ttcaagctcc acttcaagct ctacagcgga ag                                     32


<210>  71
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  71
gacagaaggc tatccatctc ctcagaaagt cc                                     32


<210>  72
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  72
tgtgaaaata agagcaaggc agtg                                              24


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  73
cattcatggc cttgtagaca cc                                                22


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  74
gcctcagaag catgataagc                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  75
cccagagtga tacagatgtc                                                   20


<210>  76
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  76
tccagaactt acggaagcac ccacg                                             25


<210>  77
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  77
caggttcact gaagttggcg atcac                                             25


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  78
agggctggca ttgttctcta                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  79
cttcagaggc aggaaacagg                                                   20


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  80
cgctcgcttc tctgtgca                                                     18


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  81
attttctgaa ccaagggagc t                                                 21


<210>  82
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  82
tgccggctcc tcagtgctg                                                    19


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  83
aaactttttg accgcccttg a                                                 21


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  84
attgaccact acctgggcaa                                                   20


<210>  85
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  85
gagatacact tcaacacttt gacct                                             25


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  86
cagaaaccat cagcaagcag g                                                 21


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  87
ttgacaaaag cctgggtggg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  88
gaccctgcaa gatgcaagcc                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  89
gagcggatga aggtaaagcg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  90
cccaccctac gaagtaccaa                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  91
ctggtcaagg tcatggtgtg                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  92
cccacctaca ggcccttctc                                                   20


<210>  93
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  93
ggcatgggca tccacagt                                                     18


<210>  94
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  94
gaacaaaaag gtacatggcc cctga                                             25


<210>  95
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  95
ccttctgttc cctcttcagt gaggta                                            26


<210>  96
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  96
atgcccatcg tgcacaggga cctca                                             25


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  97
cgttctgcca cactgggctg tga                                               23


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  98
gtagccctgc tcactcttct t                                                 21


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  99
aggtacagtc ccgtgtcaac                                                   20


<210>  100
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  100
ggagatcctt cgaggagcag cactt                                             25


<210>  101
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  101
ggcgatttag cagcagatat aagaa                                             25


<210>  102
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  102
tttagaggcc atacccatgt ctatcccccc cgaggtcaag ttcaacaaac ccctttgtct       60

tt                                                                      62


<210>  103
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  103
tttagaggcc atatgcatgt ctatcccccc cgaggtcaag ttcaacaaac ccctttgtct       60

tt                                                                      62


