                         SEQUENCE LISTING

<110>  Washington State University
       Srikumaran, Subramaniam
       Shanthalingam, Sudarvili
 
<120>  COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CONDITIONS 
       AND DISEASES ASSOCIATED WITH MANNHEIMIA HAEMOLYTICA

<130>  67901-057WO0

<150>  61-149,278
<151>  2009-02-02

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  2817
<212>  DNA
<213>  Bos taurus

<400>  1
gtcttcccag atccgcgaag caccagcctg gtgaagagca gagccgaagc ccctgccagt       60

ccagctggga cacccctgcc gaggtctcca gggcatccag gggacatgct gcgccagcgc      120

ccccagctgc tgctcctagc gggcctgctt gccctccagt ccgtcctgtc ccaggagtgc      180

accaactaca aggtcagcac ctgccgggac tgcatcgagt cgggccccgg ctgcgcctgg      240

tgccagaaac tgaacttcac agggcaaggg gagcccgact ccattcgctg tgacacacga      300

gcggagctgc tgtcaaaggg ctgcccagct gatgacatca tggaacccaa gagcctcgct      360

gagacccggg acagccaggc gggcagtcgg aagcagctgt ccccacagga agtgacgctc      420

tacctgagac caggtcaggc agttgcgttc aacgtgacct tccggagggc caagggctac      480

cccatcgacc tgtactacct gatggacctc tcctactcca tggtggatga cctcgtcaac      540

gtcaagaagc tggggggtga cctgctccgg gccctcaatg gcatcaccga gtcgggccgc      600

attggtttcg ggtccttcgt ggacaagacg gtgctcccct tcgtcaacac gcaccccgag      660

aagctgcgga acccctgccc caacaaggag aaggagtgcc agcccccgtt cgccttcagg      720

cacgtgttga agctcactga caactccaaa cagttcgaga cagaagtcgg gaagcagctg      780

atctcgggga acctggacgc ccctgagggt gggctggacg ccatgatgca ggtggccgcg      840

tgcccggagg aaatcggctg gcgcaatgtc accaggctgc tggtgttcgc cacggacgat      900

gggttccact ttgcgggcga tggaaagctg ggtgccatcc tcacccccaa tgacggccgc      960

tgccacctgg aagacaacct gtacaaaagc agcaacgaat ttgactaccc atcggtgggc     1020

cagctggcac acaaactggc agaaagcaac atccagccca tctttgcagt aaccaagaag     1080

atggtgaaaa cgtacgagaa gctgacagag atcatcccca agtctgcagt cggggagctg     1140

tctgaagatt ccaggaacgt ggtggagctt atcaagaatg cctacaataa actgtcctcc     1200

agagtcttcc tggatcacag caccctccct gacaccctga aagtcaccta cgactccttc     1260

tgcagtaacg ggaaatcgca ggtggaccag cccagagggg actgcgacgg cgtccagatc     1320

aacgtcccga tcaccttcca ggtgaaggtc acagccaccg agtgcatcca gcagcagtcc     1380

ttcaccatcc gggcgctggg cttcacggac acggtgaccg tgcgggtcct cccccagtgc     1440

gagtgccaat gccgggacgc cagcagggac ggcagcatct gcggcggcag aggctcgatg     1500

gagtgcggcg tctgcaggtg tgacgccggc tacatcggga agaactgcga gtgccagacg     1560

cagggccgga gcagccagga gctggagggc agctgccgca aggacaacag ctccatcatc     1620

tgctcggggc tgggggactg catctgcggg cagtgcgtgt gccacacgag cgacgtgccc     1680

aacaagaaga tctacggcca gttctgcgag tgcgacaacg tcaactgcga acgctacgac     1740

ggccaagtct gcgggggcga aaagaggggg ctctgcttct gcggcacctg caggtgcgac     1800

gagcagtatg agggttcggc atgccagtgc ctcaagtcca ctcagggctg cctcaacttg     1860

gacggcgtcg agtgcagcgg ccgcggccga tgccgctgca atgtgtgcca gtgcgacccc     1920

ggctaccagc cgcccctgtg cagcgagtgc ccgggctgcc ccgtgccctg tgcgggcttc     1980

gccccctgca cagagtgcct gaagttcgac aagggcccct tcgccaagaa ctgcagcgca     2040

gcgtgcgggc agacgaagct gctgtccagc ccggtgcccg gccgcaagtg caaggagcgc     2100

gactccgagg gctgctggat gacctacacc ctggtgcagc gcgacgggcg ggacagatac     2160

gacgtgcacg tggacgacat gctcgagtgt gtgaagggcc ccaacatcgc tgccatcgtg     2220

gggggcaccg tggggggcgt cgtgctcgtc ggcatcctcc tgctggtcat ctggaaggcc     2280

ctgacacacc tgagcgacct cagggagtac catcgctttg agaaggagaa gctcaagtcc     2340

cagtggaaca acgataaccc tcttttcaag agtgccacca cgacagtcat gaaccctaag     2400

tttgccgaga gttaggggtg cccggtgaag acaaggcctt ctgcaccacc cagatgggaa     2460

caccccctct ccacgtcccc tccagcaggc tgaccgtgac cccgctgcct cgtggacgtg     2520

gctgacaact tcaccgttaa ccaaaaatgc actgcttttt ctgccccaga atgatgggcg     2580

tggccaggtt attctatggg ctcatggtaa gggccagcct accccttctg atatgaatga     2640

cttttgatag caagtcagag aaggaattgc ctacattttg tatggttaca cacaggtcct     2700

ttgtaaaaat tagtacagca gtctgatgaa gaattattta tgtgtgaact tctcagggta     2760

tgaagttaca tccccttggt tatgctgccc ccaatcaata aaaaaaaaaa aatcaat        2817


<210>  2
<211>  769
<212>  PRT
<213>  Bos taurus

<400>  2

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Asn Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Glu Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Asp Ser Gln Ala Gly Ser Arg Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Val Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Val 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Gly Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Arg Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Lys Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Gln Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Gly Ser Ile Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asp Glu Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ser Glu Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  3
<211>  2362
<212>  DNA
<213>  Bison bison

<400>  3
ggcatccagg ggacatgctg cgccagcgcc cccagctgct gctcctagcg ggcctgcttg       60

ccctccagtc cgtcctgtcc caggagtgca ccaagtacaa ggtcagcacc tgccgggact      120

gcatcgagtc gggccctggc tgcgcctggt gccagaaact gaacttcaca gggcaagggg      180

agcccgactc cattcgctgt gacacacgag cggagctgct gtcaaagggc tgcccagctg      240

atgacatcat ggaacccaag agcctcgctg agaccctgga cagccaggcg ggcagtcgga      300

agcagctgtc cccacaggaa gtgacgctct acctgagacc aggtcaggca gctgcgttca      360

gcgtgacctt ccagagggcc aagggctacc ccatcgacct gtactacctg atggacctct      420

cctactccat ggtggatgac ctcgtcaatg tcaagaagct ggggggtgac ctgctccggg      480

ccctcaatgg catcaccgag tcgggccgca ttggtttcgg gtccttcgtg gacaagacgg      540

tgctcccctt cgtcaacacg caccccgaga agctgcggaa cccctgcccc aacaaggaga      600

aggagtgcca gcccccgttc gccttcaggc acgtgttgaa gctcactgac aactccaaac      660

agttcgagac agaagtcggg aagcagctga tctcggggaa cctggacgcc cctgagggtg      720

ggctggacgc catgatgcag gtggccgcgt gcccggagga aatcggctgg cgcaatgtca      780

ccaggctgct ggtgttcgcc acggacgatg ggttccactt tgcgggcgat ggaaagctgg      840

gtgccatcct cacccccaat gacggccgct gccacctgga agacaacctg tacaaaagca      900

gcaacgaatt tgactaccca tcggtgggcc agctggcaca caaactggca gaaagcaaca      960

tccagcccat ctttgcagta accaagaaga tggtgaaaac gtacgagaag ctgacagaga     1020

tcatccccaa gtctgcagtc ggggagctgt ctgaagattc caagaacgtg gtggagctta     1080

tcaagaatgc ctacaataaa ctgtcctcca gagtcttcct ggatcacagc accctccctg     1140

acaccctgaa agtcacctac gactccttct gcagtaacgg gaaatcgcag gtggaccagc     1200

ccagagggga ctgcgacggc gtccagatca acgtcccgat caccttccag gtgaaggtca     1260

cagccaccga gtgcatccag cagcagtcct tcaccatccg ggcgctgggc ttcacggaca     1320

cggtgaccgt gcgggtcctc ccccagtgcg agtgccaatg ccgggacgcc agcagggacg     1380

gcagcatctg cggcggcaga ggctcgatgg agtgcggcgt ctgcaggtgt gacgccggct     1440

acatcgggaa gaactgcgag tgccagacgc agggccggag cagccaggag ctggagggca     1500

gctgccgcaa ggacaacagc tccatcatct gctcggggct gggggactgc atctgcgggc     1560

agtgcgtgtg ccacacgagc gacgtgccca acaagaagat ctacggccag ttctgcgagt     1620

gcgacaacgt caactgcgaa cgctacgacg gccaagtctg cgggggcgaa aagagggggc     1680

tctgcttctg cggcacctgc aggtgcgacg agcagtatga gggttcggca tgccagtgcc     1740

tcaagtccac tcagggctgc ctcaacttgg acggcgtcga gtgcagcggc cgcggccgat     1800

gccgctgcaa tgtgtgccag tgcgaccccg gctaccagcc gcccctgtgc agcgagtgcc     1860

cgggctgccc cgtgccctgc gcgggcttcg ccccctgcac agagtgcctg aagttcgaca     1920

agggcccctt cgccaagaac tgcagcgcag cgtgcgggca gacgaagctg ctgtccagcc     1980

cggtgcccgg ccgcaagtgc aaggagcgcg actccgaggg ctgctggatg acctacaccc     2040

tggtgcagcg cgacgggcgg gacagatacg acgtgcacgt ggacgacatg ctcgagtgtg     2100

tgaagggccc caacatcgct gccatcgtgg ggggcaccgt ggggggcgtc gtgctcgtcg     2160

gcatcctcct gctggtcatc tggaaggccc tgacacacct gagcgacctc agggagtacc     2220

atcgcttcga gaaggagaag ctcaagtccc agtggaacaa cgataaccct cttttcaaga     2280

gtgccaccac gacagtcatg aaccctaagt ttgccgagag ttaggggtgc ccggtgaaga     2340

caaggccttc tgcaccaccc ag                                              2362


<210>  4
<211>  769
<212>  PRT
<213>  Bison bison

<400>  4

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Glu Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Leu Asp Ser Gln Ala Gly Ser Arg Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Ser Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Val 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Gly Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Lys Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Gln Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Gly Ser Ile Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asp Glu Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ser Glu Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  5
<211>  2315
<212>  DNA
<213>  Bubalus bubalis

<400>  5
atgctgcgcc agcgccccca gctgctgttc ctatcgggcc tgctcgccct ccagtccgtc       60

ctgtcccagg agtgcaccaa gtacaaggtc agcacctgcc gggactgcat cgagtctggc      120

cccggctgcg cctggtgcca gaaactgaac ttcacagggc aaggggagcc tgactccctt      180

cgctgtgaca cacgggcgga gctgctgtca aagggctgcc cagctgatga catcatggaa      240

cccaagagcc ttgctgagac ccgggacagc caggcggaca gacagaagca gctgtcccca      300

caggaagtga cgctctacct gagaccaggt caggcagctg cgttcaacgt gaccttccgg      360

agggccaagg gctaccccat cgacctgtac tacctgatgg acctctccta ctccatggtg      420

gacgacctca tcaacgtcaa gaagctgggg ggtgacctgc tccgggccct caacgacatc      480

accgagtcgg gccgcattgg tttcgggtcc ttcgtggaca agacggtgct cccattcgtc      540

aacacgcacc ccgagaagct gcggaacccc tgccccaaca aggagaagga gtgccagccc      600

ccgttcgcct tcaggcacgt gttgaagctc accgacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc ggggaacctg gacgcccctg agggtgggct ggacgccatg      720

atgcaggtgg ctgcgtgccc ggaggaaatc ggctggcgca atgtcaccag gctgctggtg      780

tttgccacag acgatgggtt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaatgacg gccgctgcca cctggaagac aacctgtaca aaagcggcaa cgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttt      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cagagatcat ccccaagtct     1020

gcagtcgggg agctgtctga agattccaag aacgtggtgg agcttatcaa gaatgcctac     1080

aataaactgt cctccagagt cttcctggat cacagcaccc tccctgacac cctgaaagtc     1140

acctacgact ccttctgcag taacagggta tcgcaggtgg accagcccag aggggactgc     1200

gacggcgttc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccagcagc agtccttcac catccgggcg ctgggcttca cggacacggt gaccgtgcgg     1320

gtcctccccc agtgcgagtg ccaatgccgg gacgccagca gggacggcag catctgcggc     1380

ggcagaggct cgatggagtg cggcgtctgc aagtgtgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcaggg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aatagctcca tcatctgctc ggggctgggg gactgtatct gcgggcagtg cgtgtgccac     1560

acgagcgacg tgcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgaacgct acgacggcca agtctgcggg ggcgaaaaga gggggctctg cttctgcggc     1680

acctgcaggt gcgacgagca gtatgagggt tcggcatgcc agtgcctcaa gtccactcag     1740

ggctgcctca acttggacgg cgtcgagtgc agcggccgcg gccgatgccg ctgcaatgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcagcg agtgcccggg ctgccccgtg     1860

ccctgtgcgg gcttcgcccc ctgcacagag tgcctgaagt tcgacaaggg ccccttcgcc     1920

aagaactgca gcgcagcgtg cgggcagacg aagctgctgt ccagcccggt gcccggccgc     1980

aagtgcaagg agcgcgactc cgagggctgc tggatgacct acaccctggt gcagcgcgac     2040

gggcgggaca gatacgacgt gcacgtggac gacatgctcg agtgtgtgaa gggccccaac     2100

atcgctgcca tcgtgggggg caccgtgggg ggcgtcgtgc tcgtcggcat cctcctgctg     2160

gtcatctgga aggccctgac acacctgagc gacctcaggg agtaccatcg ctttgagaag     2220

gagaagctca agtcccagtg gaacaacgat aaccctcttt tcaagagtgc caccacgaca     2280

gtcatgaacc ctaagtttgc cgagagttag gggtg                                2315


<210>  6
<211>  769
<212>  PRT
<213>  Bubalus bubalis

<400>  6

Met Leu Arg Gln Arg Pro Gln Leu Leu Phe Leu Ser Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Leu Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Glu Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Asp Ser Gln Ala Asp Arg Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ile 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Gly Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Arg Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Gln Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Gly Ser Ile Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Lys Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asp Glu Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ser Glu Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  7
<211>  2507
<212>  DNA
<213>  Capra hircus

<400>  7
cagcctggtg aagagcagag ccgaagcccc tgccagtcca gctgggacac ccctgccgtg       60

gtctccaggg catccagggg acatgctgcc ccagcgcccc cagctgctgc tcctagcagg      120

cctgctcgcc ctccagtctg tcctgtccca ggagtgcacc aagtacaaag tcagcacctg      180

ccgggactgc atcgagtcgg gccccggctg tgcctggtgc cagaaactga acttcacagg      240

gcaaggggag cccgactcca ctcgctgtga tacacgggcg cagctgctgt caaagggctg      300

cccagctgat gacatcatgg aacccaagag cctcgctgag acccggcaga gccaggcggg      360

caaacagaag cagctgtccc cagaggaagt gactctctac cttagaccag gtcaggcagc      420

tgcgttcaat gtgaccttcc agagggccaa gggctacccc atcgacctgt actatctgat      480

ggatctctcc tactccatgg tggacgacct cgccaacgtc aagaagctgg ggggtgacct      540

gctccgggcc ctcaatgaca tcaccgagtc gggccgcatc gggttcgggt ccttcgtgga      600

caagacagtg ctccccttcg tcaacacgca ccctgagaag ctgaggaacc cctgccccaa      660

caaggagaag cagtgccagc ccccgttcgc cttcaggcac gtgttgaagc tcaccgacaa      720

ctccaaacag ttcgagacag aagtcgggaa gcagctgatc tcggggaact tggacgcccc      780

tgagggtgga ctggacgcca tgatgcaagt ggccgcgtgc ccggaggaaa tcggctggcg      840

caatgtcacc aggctgctgg tgttcgccac agatgatggg ttccactttg cgggcgatgg      900

aaagctgggt gccatcctca cccccaacga cggccgctgc cacctggaag acaacctgta      960

caaaagcagc aacgaatttg actacccatc ggtgggccag ctggcacaca aactggcaga     1020

aagcaacatc cagcccatct tcgcggtaac caagaagatg gtgaaaacgt acgagaagct     1080

gacagaaatc atccccaagt ctgcagtcgg ggagctgtct gaagattcca agaacgtggt     1140

ggagcttatc aagagtgcct acaataaact gtcctccaga gtattcctgg atcacaacac     1200

cctccctgac accctgaaag tcgcctacga ctccttctgc agtaacgggg tgtcacaggt     1260

ggaccagccc agaggggact gtgacggcgt ccagatcaac gtcccgatca ccttccaggt     1320

gaaggtcaca gccaccgagt gcatccagga gcagtccttc accatccggg cgctgggctt     1380

cacggacacg gtgaccgtgc gggtccttcc ccagtgcgag tgccaatgcc gggacgccag     1440

cagggaccgc agcgtctgcg gtggcagagg ctcgatggag tgcggcgtct gcaggtgcga     1500

cgccggctac atcgggaaga actgcgagtg ccagacgcac ggccggagca gccaggagct     1560

ggagggcagc tgccgcaagg acaacagctc catcatctgc tcggggctag gggactgcat     1620

ctgcgggcag tgcgtgtgcc acacgagcga cgtgcccaac aagaagatct acggccagtt     1680

ctgcgagtgc gacaacgtca actgcgagcg ctacgacggc caagtctgcg ggggcgagaa     1740

gagggggctc tgcttctgcg gcacctgcag gtgcaacgag cagcatgagg gctcggcgtg     1800

ccagtgcctc aagtccactc agggctgcct caacctggac ggcgtcgagt gcagcggccg     1860

gggccgatgc cgctgcaacg tgtgccagtg cgaccccggc taccagccgc ccctgtgcat     1920

cgactgcccg ggctgccccg tgccctgcgc tggcttcgcc ccctgcaccg agtgcctgaa     1980

gttcgacaag ggccccttcg ccaagaactg cagcgcagcg tgcgggcaga cgaagctgct     2040

gtccagcccg gtgcccggcg gccgcaagtg caaggagcgc gactccgagg gctgctggat     2100

gacctacacc ctggtgcagc gcgacgggcg gaacagatac gacgtgcacg tggacgacat     2160

gctcgagtgt gtgaagggcc ccaacatcgc tgccatcgtg gggggcaccg tggggggagt     2220

tgtgctcgtc ggcatcctcc tgctggtcat ctggaaggcc ctgacacacc tgagcgacct     2280

cagggagtac catcgcttcg agaaggagaa gctcaagtcc cagtggaaca acgataaccc     2340

tcttttcaag agtgccacca cgacagtcat gaaccctaag tttgccgaga gttaggggtg     2400

cctggtgaag acaaggcctt ctgcaccacc cagacgggag cacgccctct cctcatcccc     2460

tccagcaggc tgaccgtgac cttgctgctt agtggacgca gctgatg                   2507


<210>  8
<211>  770
<212>  PRT
<213>  Capra hircus

<400>  8

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Thr Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Gln Ser Gln Ala Gly Lys Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Glu Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ala 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Gln Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Ala Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr His Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asn Glu Gln His Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ile Asp Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asn Arg Tyr Asp Val 
        675                 680                 685             


His Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  9
<211>  2313
<212>  DNA
<213>  Ovis aries

<400>  9
atgctgcccc agcgccccca gctgctgctc ctagcgggcc tgctctccct ccagtccgtc       60

ctgtcccagg agtgcaccaa gtacaaagtc agcacctgcc gggactgcat cgagtcgggc      120

cccggctgtg cctggtgtca gaaactgaac ttcacagggc aaggggagcc cgactccact      180

cgctgtgata cacgggcgca gctgctgtcg aagggctgcc cagctgatga catcatggaa      240

cccaagagcc tcgctgagac tcggcagagc caggcgggca aacagaagca gctgtcccca      300

gaggaagtga ccctctacct gagaccaggt caggcagcag cgttcaacgt gaccttccag      360

agggccaagg gctaccccat cgacctgtac tatctgatgg atctctccta ctccatggtg      420

gacgacctcg ccaacgtcaa gaagctgggg ggtgacctgc tccgggccct caatgacatc      480

accgagtcag gccgcattgg tttcgggtcc ttcgtggaca agacggtgct ccccttcgtc      540

aacacgcacc ccgagaagct gaggaacccc tgccccaaca aggagaagga gtgccagccg      600

ccgttcgcct tcaggcacgt gctgaagctc accgacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc ggggaacttg gacgcccctg agggtgggct ggacgccatg      720

atgcaagtgg ccgcgtgccc ggaggaaatt ggctggcgca atgtcaccag gctgctggtg      780

ttcgccacag acgatgggtt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaacgacg gccgctgcca cctggaagac aacctgtaca aaagcagcaa cgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttc      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cagaaatcat ccccaagtct     1020

gcagtcgggg agctgtctga agattccaag aacgtggtgg agcttatcaa gagtgcctac     1080

aataaactgt cctccagagt attcctggat cacaacaccc tccctgacac cctgaaagtc     1140

gcctacgact ccttctgcag taacggggtg tcgcaggtgg accagcccag aggggactgc     1200

gacggcgtcc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccaggagc agtccttcac catccgggcg ctgggcttca cggacacggt gaccgtgcgg     1320

gtccttcccc agtgcgagtg ccaatgccgg gaagccagca gggaccgcag cgtctgcggt     1380

ggcagaggct cgatggagtg cggcgtctgc aggtgcgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcacgg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aacagctcca tcatctgctc ggggctgggg gactgcatct gcgggcagtg cgtgtgccac     1560

acgagcgacg tgcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgagcgct acgacggcca agtctgcggg ggcgacaaga gggggctctg cttctgcggc     1680

acctgcaggt gcaacgacca gcatgagggc tcggcgtgcc agtgcctcaa gtccactcag     1740

ggctgcctca acctggacgg cgtcgagtgc agcggccgcg gccgatgccg ctgcaacgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcatcg actgcccggg ctgccccgtg     1860

ccctgcgctg gcttcgcccc ctgcaccgag tgcctgaagt tcgacaaggg tcccttcgcc     1920

aagaactgca gcgcagcgtg cgggcagacg aagctgctgt ccagcccggt gcccggcggc     1980

cgcaagtgca aggagcgtga ctccgagggc tgctggatga cctacaccct ggtgcagcgc     2040

gacgggcgga acagatacga cgtgcacgtg gacgacatgc tcgagtgtgt gaagggcccc     2100

aacatcgctg ccatcgtggg gggcaccgtg gggggagttg tgctcgtcgg catcctcctg     2160

ctggccatct ggaaggccct gacacacctg agcgacctca gggagtacca tcgcttcgag     2220

aaggagaagc tcaagtccca gtggaacaac gataaccctc ttttcaagag tgccaccacg     2280

acagtcatga accctaagtt tgccgagagt tag                                  2313


<210>  10
<211>  770
<212>  PRT
<213>  Ovis aries

<400>  10

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Thr Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Gln Ser Gln Ala Gly Lys Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Glu Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ala 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Ala Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Glu Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr His Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asn Asp Gln His Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ile Asp Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asn Arg Tyr Asp Val 
        675                 680                 685             


His Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Ala Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  11
<211>  2313
<212>  DNA
<213>  Ovis canadensis

<400>  11
atgctgcccc agcgccccca gctgctgctc ctagcgggcc tgctctccct ccagtccgtc       60

ctgtcccagg agtgcaccaa gtacaaggtc agcacctgcc gggactgcat cgagtcgggc      120

cccagctgtg cctggtgcca gaaactgaac ttcacagggc aaggggagcc cgactccact      180

cgctgtgata caagggcgca gctgctgtcg aagggctgcc cagctgatga catcatggaa      240

cccaagagcc tcgctgagac ccggcagagc caggcgggca gacagaagca gctgtcccca      300

gaggaagtga ccctctacct gagaccaggt caggcagctg cgttcaacgt gaccttccag      360

agggccaagg gctaccccat cgacctgtac tatctgatgg atctctccta ctccatggtg      420

gacgacctcg ccaacgtcaa gaagctgggg ggtgacctgc tccgggccct caatgacatc      480

accgagtcgg gccgcattgg tttcgggtcc ttcgtggaca agacggtgct ccccttcgtc      540

aacacgcacc ccgagaagct gaggaacccc tgccccaaca aggagaagga gtgccagccg      600

ccgttcgcct tcaggcacgt gctgaagctc accgacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc ggggaacttg gacgcccctg agggtgggct ggacgccatg      720

atgcaagtgg ccgcgtgccc ggaggaaatt ggctggcgca atgtcaccag gctgctggtg      780

ttcgccacag acgatgggtt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaacgacg gccgctgcca cctggaagac aacctgtaca aaagcagcaa cgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttc      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cagaaatcat ccccaagtct     1020

gcagtcgggg agctgtctga agattccaag aacgtggtgg agcttatcaa gagtgcctac     1080

aataaactgt cctccagagt attcctggat cacaacaccc tccctgacac cctgaaagtc     1140

gcctacgact ccttctgcag taacagggtg tcacaggtgg accagcccag aggggactgt     1200

gacggcgtcc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccaggagc agtccttcac catccgggcg ctgggcttca cggacacggt gaccgtgcgg     1320

gtccttcccc agtgcgagtg ccaatgccgg gaagccagca gggaccgcgg cgtctgcggt     1380

ggcagaggct cgatggagtg cggcgtctgc aggtgcgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcacgg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aacagctcca tcatctgctc ggggctgggg gactgcatct gcgggcagtg cgtgtgccac     1560

acgagcgacg tgcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgagcgct acgacggcca agtctgcggg ggcgacaaga gggggctctg cttctgcggc     1680

gcctgcaggt gcaacgacca gtatgagggc tcggcgtgcc agtgcctcaa gtccactcag     1740

ggctgcctca acctgaacgg cgtcgagtgc agcggccgcg gccgatgccg ctgcaacgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcatcg actgcccggg ctgccccgtg     1860

ccctgcgctg gcttcgcccc ctgcaccgag tgcctgaagt tcgacaaggg tcccttcgcc     1920

aagaactgca gcgcagcgtg cgggcagacg aagctgctgt ccagcccggt gcccggcggc     1980

cgcaagtgca aggagcgtga ctccgagggc tgctggatga cctacaccct ggtgcagcgc     2040

gacgggcgga acagatacga cgtgcacgtg gacgacatgc tcgagtgtgt gaagggcccc     2100

aacatcgctg ccatcgtggg gggcaccgtg gggggagttg tgctcgtcgg catcctcctg     2160

ctggccatct ggaaggccct gacacacctg agcgacctca gggagtacca tcgcttcgag     2220

aaggagaagc tcaagtccca gtggaacaac gataaccctc ttttcaagag tgccaccacg     2280

acagtcatga accctaagtt tgccgagagt tag                                  2313


<210>  12
<211>  770
<212>  PRT
<213>  Ovis canadensis

<400>  12

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Ser Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Thr Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Gln Ser Gln Ala Gly Arg Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Glu Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ala 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Ala Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Arg Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Glu Ala Ser Arg Asp Arg Gly Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr His Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Ala Cys Arg Cys Asn Asp Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asn Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ile Asp Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asn Arg Tyr Asp Val 
        675                 680                 685             


His Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Ala Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  13
<211>  2310
<212>  DNA
<213>  Odocoileus hemionus

<400>  13
atgctgcgcc agcgccccca gctgctgctc ctagcaggcc tgctagccct ccagtctgtc       60

cggtcccagg agtgcaccaa atacaaggtc agcacctgcc gggactgcat cgagtcgggc      120

cccggctgtg cctggtgcca gaagctgaac ttcacagggc aaggggagcc cgactccgct      180

cgctgtgaca cacgggcgca gctgctgtcc aagggctgtg ccactgatga catcatggaa      240

cccaggagcc tcgctgagac ccaggagagc caggcaggca gacagaagca gctgtcccca      300

caggaagtga cgctctacct gagaccaggt caggcagctg cgttcaacgt gactttccgg      360

agggccaaag gataccccat cgacctgtac tacctgatgg atctctccta ctccatggtg      420

gacgacctcg tcaacgtcaa gaagctgggg ggtgacctgc tccgggccct caacggcatc      480

actgagtcgg gccgcatcgg tttcgggtcc ttcgtggaca agacggtgct cccctttgtc      540

aacacgcacc ccgagaagct gcggaacccc tgccccaaca aggagaagca gtgccagccc      600

ccgttcgcct tcaggcacgt gctgaagctc accaacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc gggaaacctg gacgcccccg agggagggct ggacgccatg      720

atgcaggtgg ccgtgtgccc ggaggaaatc ggctggcgca atgtcaccag gctgctggtg      780

tttgccacgg atgatggctt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaacgacg gccgctgcca cctggaagac aacctgtaca aaagcagcaa tgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttt      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cggagatcat ccccaagtct     1020

gcagtcgggg agctgtctga agactccagg aacgtggtgg agcttatcaa gagtgcctac     1080

aacaaactgt cctccagagt cttcctggat cacaacaccc tccctgacac cctgaaagtc     1140

acctacgact ccttctgcag taacggggtg tcgaaggtgg accagcccag aggggactgc     1200

gacggcgtcc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccaggagc agtccttcac catccgggcc ctgggcttta cggacacggt gaccgtgcgg     1320

gtcctccccc agtgcgagtg ccaatgccgg gacgcgagca gggaccgcag cgtctgcggt     1380

ggcagaggct cgatggagtg cggcgtctgc aggtgcgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcaggg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aacagctcca tcatctgctc ggggctgggg gactgcatct gcgggcagtg cgtgtgccac     1560

acgagcgacg ttcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgagcgct acgacggcca agtctgcggg ggcgacaaga gggggctctg cttctgcggc     1680

acctgcaggt gccaggacca gtacgagggc tcggcgtgcc agtgcctcaa gtccacgcag     1740

ggctgcctca acctgaacgg cgtcgagtgc agcggccgcg gccggtgccg ctgcaacgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcaaag agtgcccggg ctgccccgcg     1860

ccctgcgccg gctttgcctc ctgcaccgag tgcctgaagt tcgacaaggg ccccttcgcc     1920

aagaactgca gcgcagcttg cggggagacg aagctgctgt ccagcccgcc gcccggccgc     1980

aagtgcaagg agcgcgactc cgagggctgc tggatgacct acaccctggt gcagcgcgac     2040

gggcgggaca gatacgacgt gcacgtgaac gacacgcgcg agtgtgtaaa gggccccaac     2100

atcgctgcca ttgtgggggg caccgtggcg ggagttgtgc ttgtcggcat cctcctgctg     2160

gtcatctgga aggccctgac acacctgagc gacctcaggg agtaccatcg cttcgagaag     2220

gagaagctca agtcccagtg gaacaacgat aaccctcttt tcaagagtgc caccacgaca     2280

gtcatgaacc ctaagtttgc cgagagttag                                      2310


<210>  14
<211>  769
<212>  PRT
<213>  Odocoileus hemionus

<400>  14

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Arg Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ala Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Ala Thr Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Arg Ser Leu Ala Glu Thr Gln Glu Ser Gln Ala Gly Arg Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Val 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Gly Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Gln Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Val Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Arg Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Lys Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Gln Asp Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asn Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Lys Glu Cys Pro Gly Cys Pro Ala Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Ser Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Glu Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Pro Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asn Asp Thr Arg Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  15
<211>  2824
<212>  DNA
<213>  Cervus elaphus

<400>  15
aagcaccagc ctggtgaaga gcagagccga agcccctgcc agtccagccg ggacgtccct       60

gccgaggtct ccagggcatc cagtgggaca tgctgcgcca gcgcccccag ctgctgctcc      120

tagcgggcct gctagccctc cagtctgtcc agtcccagga gtgcaccaag tacaaggtca      180

gcacctgccg ggactgcatc gagtcgggcc ccggctgtgc ctggtgccag aagctgaact      240

tcacagggca aggggagccc gactccgctc gctgtgacac acgggcgcag ctgctgtcaa      300

agggctgtgc cgctgatgac atcatggatc ccaggagcct cgctgagacc cgggagagcc      360

aggcgggcag acagaagcag aagcagctgt ccccacagga agtgacgctc tacctgagac      420

caggtcaggc agctgcgttt aacgtgactt tccagagggc caagggctac cccatcgacc      480

tgtactacct gatggacctc tcctactcca tggtggatga cctcgtcaac gtcaagaagc      540

tggggggtga cctgctccgg gccctcaacg acatcaccga gtcgggccgc atcggtttcg      600

ggtccttcgt ggacaagacg gtgctccctt tcgtcaacac gcaccccgag aagctgcgga      660

acccctgccc caacaaggag aagcagtgcc agcccccgtt cgccttcagg cacgtgctga      720

agctcaccga caactccaaa cagttcgaga cagaagtcgg gaagcagctg atctcgggga      780

acctggacgc ccccgaggga gggctggacg ccatgatgca ggtggccgcg tgcccggagg      840

aaatcggctg gcgcaatgtc accaggttgc tggtgtttgc cacggatgat ggcttccact      900

ttgcgggcga tggaaagctg ggtgccatcc tcacccccaa cgacggccgc tgccacctgg      960

aagacaacct gtacaaaagc agcaacgaat ttgactaccc atcggtgggc cagctggcac     1020

acaaactggc agaaagcaac atccagccca tctttgcggt aaccaagaag atggtgaaaa     1080

cgtacgagaa gctgacggag atcatcccca agtctgcagt cggggagctg tctgaagatt     1140

ccaagaacgt ggtggagctt atcaagagtg cctacaataa actgtcctcc agagtcttcc     1200

tggatcacaa caccctccct gacaccctga aagtcaccta cgactccttc tgcagtaaag     1260

gggtgtcgaa ggtggaccag cccagagggg actgcgacgg cgtccagatc aacgtcccga     1320

tcaccttcca ggtgaaggtc acagccaccg agtgcatcca ggaacagtcc ttcaccatcc     1380

gggcgctggg ctttacggac acggtgaccg tgcgggtcct cccccagtgc gagtgccaat     1440

gccgggacgc gagcagggac cgcagcgtct gcggtggcag aggttcgatg gagtgcggcg     1500

tctgcaggtg cgacgccggc tacatcggga agaactgcga gtgccagacg cagggccgga     1560

gcagccagga gctggagggc agctgccgca aggacaacag ctccatcatc tgctcggggc     1620

tgggggactg catctgcggg cagtgcgtgt gccacacgag cgacgtgccc aacaagaaga     1680

tctacggcca gttctgcgag tgtgacaacg tcaactgcga acgctacgac ggccaagtct     1740

gcgggggcga caagaggggg ctctgcttct gcggcacctg caggtgccag gaccagtacg     1800

agggctcggc gtgccagtgc ctcaagtcca cgcagggctg cctcaacctg aacggcgtcg     1860

agtgcagcgg ccgcggccgg tgccgctgca acgtgtgcca gtgcgacccc ggctaccagc     1920

cgcccctgtg cttagagtgc cccggctgcc ccgcaccctg cgccggcttt gccccctgca     1980

ccgagtgcct gaagttcaag ggccccttcg ccaagaactg cagcgcagcg tgcggggaga     2040

cgaagctgct gtccaacccg ctgcccggcc gcaagtgcaa ggagcgcgac tcggagggct     2100

gctggatgac ctacaccctg gtgcagcgcg acgggcggga cagatacgac gtgcacgtga     2160

acgacacgcg cgagtgtgtg aagggcccca acatcgcggc cattgtgggg ggcaccgtgg     2220

ggggagttgt gctggttggc atcctcctgc tggtcatctg gaaggccctg acacacctga     2280

gcgacctcag ggagtaccat cgcttcgaga aggagaagct caagtcccag tggaacaatg     2340

ataaccctct tttcaagagt gccaccacga cagtcatgaa ccctaagttt gccgagagtt     2400

aggggtgcct ggtgaagaca aggccttctg caccacccag atgggaccac gccctctcca     2460

cgtcccctcc agcaggccga ccgtgaccct gctgccttgt ggacgtggct gatgatgctt     2520

gacaactcca ctgttaacca aaaatgcact gcttttcctg ccccagaatg atgggcgtga     2580

ccaaatgatc ctatgggctc atggtaaggg ccagcctccc ccttgatgtc aataactttt     2640

gctagcaagt cagaggagga attgcctaca ttttgtacgg ttacacacca gtcctttgta     2700

aaaattagca cagcagtctg atgaagaatt atttatatgt gaacttctca gggtatgaag     2760

ttatatcccc ttggttatgc tgccccccaa tcaataaaaa aaatcaagaa aaaaaaaaaa     2820

aaaa                                                                  2824


<210>  16
<211>  770
<212>  PRT
<213>  Cervus elaphus

<400>  16

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Gln Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ala Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Arg Ser Leu Ala Glu Thr Arg Glu Ser Gln Ala Gly Arg Gln Lys 
                85                  90                  95      


Gln Lys Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly 
            100                 105                 110         


Gln Ala Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro 
        115                 120                 125             


Ile Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp 
    130                 135                 140                 


Leu Val Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn 
145                 150                 155                 160 


Asp Ile Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys 
                165                 170                 175     


Thr Val Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro 
            180                 185                 190         


Cys Pro Asn Lys Glu Lys Gln Cys Gln Pro Pro Phe Ala Phe Arg His 
        195                 200                 205             


Val Leu Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly 
    210                 215                 220                 


Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp 
225                 230                 235                 240 


Ala Met Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn 
                245                 250                 255     


Val Thr Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala 
            260                 265                 270         


Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys 
        275                 280                 285             


His Leu Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro 
    290                 295                 300                 


Ser Val Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro 
305                 310                 315                 320 


Ile Phe Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr 
                325                 330                 335     


Glu Ile Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys 
            340                 345                 350         


Asn Val Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg 
        355                 360                 365             


Val Phe Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr 
    370                 375                 380                 


Asp Ser Phe Cys Ser Lys Gly Val Ser Lys Val Asp Gln Pro Arg Gly 
385                 390                 395                 400 


Asp Cys Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys 
                405                 410                 415     


Val Thr Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala 
            420                 425                 430         


Leu Gly Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu 
        435                 440                 445             


Cys Gln Cys Arg Asp Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg 
    450                 455                 460                 


Gly Ser Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly 
465                 470                 475                 480 


Lys Asn Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu 
                485                 490                 495     


Gly Ser Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly 
            500                 505                 510         


Asp Cys Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn 
        515                 520                 525             


Lys Lys Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu 
    530                 535                 540                 


Arg Tyr Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe 
545                 550                 555                 560 


Cys Gly Thr Cys Arg Cys Gln Asp Gln Tyr Glu Gly Ser Ala Cys Gln 
                565                 570                 575     


Cys Leu Lys Ser Thr Gln Gly Cys Leu Asn Leu Asn Gly Val Glu Cys 
            580                 585                 590         


Ser Gly Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly 
        595                 600                 605             


Tyr Gln Pro Pro Leu Cys Leu Glu Cys Pro Gly Cys Pro Ala Pro Cys 
    610                 615                 620                 


Ala Gly Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Lys Gly Pro Phe 
625                 630                 635                 640 


Ala Lys Asn Cys Ser Ala Ala Cys Gly Glu Thr Lys Leu Leu Ser Asn 
                645                 650                 655     


Pro Leu Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val 
        675                 680                 685             


His Val Asn Asp Thr Arg Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  17
<211>  2977
<212>  DNA
<213>  Homo sapiens

<400>  17
gggccgctct ctgacatcag agctgctgta gagcggagag gggcaggggt gaagggccac       60

ggtggtgcaa cccaccactt cctccaagga ggagctgaga ggaacaggaa gtgtcaggac      120

tttacgaccc gcgcctccag ctgaggtttc tagacgtgac ccagggcaga ctggtagcaa      180

agcccccacg cccagccagg agcaccgccg aggactccag cacaccgagg gacatgctgg      240

gcctgcgccc cccactgctc gccctggtgg ggctgctctc cctcgggtgc gtcctctctc      300

aggagtgcac gaagttcaag gtcagcagct gccgggaatg catcgagtcg gggcccggct      360

gcacctggtg ccagaagctg aacttcacag ggccggggga tcctgactcc attcgctgcg      420

acacccggcc acagctgctc atgaggggct gtgcggctga cgacatcatg gaccccacaa      480

gcctcgctga aacccaggaa gaccacaatg ggggccagaa gcagctgtcc ccacaaaaag      540

tgacgcttta cctgcgacca ggccaggcag cagcgttcaa cgtgaccttc cggcgggcca      600

agggctaccc catcgacctg tactatctga tggacctctc ctactccatg cttgatgacc      660

tcaggaatgt caagaagcta ggtggcgacc tgctccgggc cctcaacgag atcaccgagt      720

ccggccgcat tggcttcggg tccttcgtgg acaagaccgt gctgccgttc gtgaacacgc      780

accctgataa gctgcgaaac ccatgcccca acaaggagaa agagtgccag cccccgtttg      840

ccttcaggca cgtgctgaag ctgaccaaca actccaacca gtttcagacc gaggtcggga      900

agcagctgat ttccggaaac ctggatgcac ccgagggtgg gctggacgcc atgatgcagg      960

tcgccgcctg cccggaggaa atcggctggc gcaacgtcac gcggctgctg gtgtttgcca     1020

ctgatgacgg cttccatttc gcgggcgacg ggaagctggg cgccatcctg acccccaacg     1080

acggccgctg tcacctggag gacaacttgt acaagaggag caacgaattc gactacccat     1140

cggtgggcca gctggcgcac aagctggctg aaaacaacat ccagcccatc ttcgcggtga     1200

ccagtaggat ggtgaagacc tacgagaaac tcaccgagat catccccaag tcagccgtgg     1260

gggagctgtc tgaggactcc agcaatgtgg tccaactcat taagaatgct tacaataaac     1320

tctcctccag ggtcttcctg gatcacaacg ccctccccga caccctgaaa gtcacctacg     1380

actccttctg cagcaatgga gtgacgcaca ggaaccagcc cagaggtgac tgtgatggcg     1440

tgcagatcaa tgtcccgatc accttccagg tgaaggtcac ggccacagag tgcatccagg     1500

agcagtcgtt tgtcatccgg gcgctgggct tcacggacat agtgaccgtg caggttcttc     1560

cccagtgtga gtgccggtgc cgggaccaga gcagagaccg cagcctctgc catggcaagg     1620

gcttcttgga gtgcggcatc tgcaggtgtg acactggcta cattgggaaa aactgtgagt     1680

gccagacaca gggccggagc agccaggagc tggaaggaag ctgccggaag gacaacaact     1740

ccatcatctg ctcagggctg ggggactgtg tctgcgggca gtgcctgtgc cacaccagcg     1800

acgtccccgg caagctgata tacgggcagt actgcgagtg tgacaccatc aactgtgagc     1860

gctacaacgg ccaggtctgc ggcggcccgg ggagggggct ctgcttctgc gggaagtgcc     1920

gctgccaccc gggctttgag ggctcagcgt gccagtgcga gaggaccact gagggctgcc     1980

tgaacccgcg gcgtgttgag tgtagtggtc gtggccggtg ccgctgcaac gtatgcgagt     2040

gccattcagg ctaccagctg cctctgtgcc aggagtgccc cggctgcccc tcaccctgtg     2100

gcaagtacat ctcctgcgcc gagtgcctga agttcgaaaa gggccccttt gggaagaact     2160

gcagcgcggc gtgtccgggc ctgcagctgt cgaacaaccc cgtgaagggc aggacctgca     2220

aggagaggga ctcagagggc tgctgggtgg cctacacgct ggagcagcag gacgggatgg     2280

accgctacct catctatgtg gatgagagcc gagagtgtgt ggcaggcccc aacatcgccg     2340

ccatcgtcgg gggcaccgtg gcaggcatcg tgctgatcgg cattctcctg ctggtcatct     2400

ggaaggctct gatccacctg agcgacctcc gggagtacag gcgctttgag aaggagaagc     2460

tcaagtccca gtggaacaat gataatcccc ttttcaagag cgccaccacg acggtcatga     2520

accccaagtt tgctgagagt taggagcact tggtgaagac aaggccgtca ggacccacca     2580

tgtctgcccc atcacgcggc cgagacatgg cttgccacag ctcttgagga tgtcaccaat     2640

taaccagaaa tccagttatt ttccgccctc aaaatgacag ccatggccgg ccgggtgctt     2700

ctgggggctc gtcgggggga cagctccact ctgactggca cagtctttgc atggagactt     2760

gaggagggag ggcttgaggt tggtgaggtt aggtgcgtgt ttcctgtgca agtcaggaca     2820

tcagtctgat taaaggtggt gccaatttat ttacatttaa acttgtcagg gtataaaatg     2880

acatcccatt aattatattg ttaatcaatc acgtgtatag aaaaaaaata aaacttcaat     2940

acaggctgtc catggaaaaa aaaaaaaaaa aaaaaaa                              2977


<210>  18
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val Gln Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  19
<211>  2828
<212>  DNA
<213>  Mus musculus

<400>  19
cgaggcccct ggcaagaagt aggcaaagac atctccagtc agattctcgg agtggaggct       60

tcctgggact gagaggggga catgctgggc ccacactcac tgctgcttgc cctagctgga      120

ctgttcttcc tgggatctgc tgtgtcccag gaatgcacca agtacaaagt cagcagttgc      180

cgggactgta tccagtcggg gcctggctgt tcctggtgcc agaagctgaa cttcactgga      240

ccaggagaac ctgactcctt gcgctgtgac acacgggcac agctgctgct gaagggttgt      300

ccagccgatg atatcatgga ccccaggagc atcgctaatc ctgagttcga ccaacggggg      360

caacggaaac agctatctcc acaaaaagtg acactttact tgcgaccagg acaggctgcc      420

gcattcaatg tgactttccg gcgggccaag ggatacccca ttgatctgta ctacctcatg      480

gatctctcct actccatgct tgatgacctc aacaacgtca agaagctggg cggggacttg      540

ctgcaggccc tcaacgagat caccgagtct ggccgcatcg gctttgggtc gtttgtggac      600

aagacggtgc tgccttttgt taacacccat cctgagaagc tgaggaaccc atgtcccaac      660

aaggagaagg cctgccagcc cccatttgcc tttcggcacg tgctcaagtt aaccgacaac      720

tccaaccagt ttcagacaga ggtcggcaag caactgattt ccggaaacct ggacgcccct      780

gagggtgggc tggatgccat aatgcaagtt gctgcatgtc cggaggaaat tggctggcgc      840

aatgtcacga ggctgctggt gtttgccaca gacgatggct tccactttgc tggtgatggc      900

aaactgggtg ccatcctgac ccccaatgat ggccgctgcc acctggagga taacatgtac      960

aagaggagca atgagttcga ctacccatcc gtgggtcagc tggcacacaa actttccgag     1020

agcaacatcc agcccatctt tgcggtgaca aagaagatgg tgaaaacgta tgagaaactc     1080

acggagatca tccccaagtc agcagtgggg gaactgtctg acgactccag caacgtggtg     1140

cagctcatca agaatgccta ctataaactc tcctctagag tcttcctgga ccacagcacc     1200

ctcccggaca ccctgaaagt cacctatgac tccttctgca gtaatggagc atcgagtata     1260

ggcaaatccc gtggggactg tgatggcgta cagatcaaca acccggtcac cttccaggta     1320

aaggtcatgg cttccgagtg tatccaggag cagtcctttg tcatccgggc actgggtttc     1380

actgatacag tgaccgtgca ggtccgtccc cagtgtgagt gtcagtgccg ggaccagagt     1440

cgggagcaga gtctctgtgg aggcaaggga gtcatggagt gtggtatctg caggtgtgag     1500

tctggctaca ttgggaaaaa ctgtgagtgc cagactcagg gtcggagcag ccaggagctg     1560

gagagaaact gtcggaagga caatagttcc atcgtgtgct cagggcttgg ggactgcatc     1620

tgtgggcagt gtgtatgcca taccagtgac gtccccaaca aagagatctt tgggcaatac     1680

tgcgagtgtg acaatgtcaa ctgtgagaga tataacagcc aagtctgcgg tggctcagat     1740

cggggttcct gcaactgtgg caaatgtagt tgcaagcccg gttacgaggg ctcggcctgc     1800

cagtgtcaga ggtccaccac gggctgtctg aatgcacggc tggtagagtg cagtggccgt     1860

ggccactgcc aatgcaacag gtgcatatgt gacgaaggct accagccacc gatgtgtgag     1920

gattgtccca gctgtggctc gcactgcagg gacaaccaca cctcttgtgc cgagtgcctg     1980

aagtttgata agggcccttt tgagaagaac tgtagtgttc agtgtgctgg tatgacgctg     2040

cagactatcc ctttgaagaa aaagccctgc aaggagaggg actcggaagg ctgttggata     2100

acttacactt tgcagcagaa ggacggaagg aacatttaca acatccatgt ggaggacagt     2160

ctagagtgtg tgaagggccc caatgtggct gccatcgtag ggggcaccgt ggtaggtgtc     2220

gtactgattg gtgtcctcct cctggtcatc tggaaggccc tgacccacct gactgacctc     2280

agggagtaca ggcgctttga gaaggagaaa ctcaagtccc aatggaacaa tgacaacccc     2340

ctcttcaaga gtgctacgac aacggtcatg aaccccaagt ttgctgaaag ctagagcatg     2400

agttatcata atcaagcaga tgtgaccccc tcagaccacg cctcctcccc tctgcaaaca     2460

caacgtggct tacagctcac cccagtgctg ccaaggatcc aaaagcctgc tcggtttctt     2520

tccgccatta tatcaagtct gccagggttt ccagggactt gtcttccgac ctgcacaatc     2580

ttgccgcaga gccctaagaa ttgtcccgag tcccaagagg ttccacccac attttcttgc     2640

ataaaggaag acagcagtct cagtaaaggt ggccccaact tatttatatt taaacttgtc     2700

agagtataaa actcctatta tattgttaac atcccatctg ttgtattata tgtgagtata     2760

aaaactatat ccaacgtatt atttcataat catgtatgaa aaataataaa gcttccatcc     2820

atgctgtc                                                              2828


<210>  20
<211>  770
<212>  PRT
<213>  Mus musculus

<400>  20

Met Leu Gly Pro His Ser Leu Leu Leu Ala Leu Ala Gly Leu Phe Phe 
1               5                   10                  15      


Leu Gly Ser Ala Val Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Asp Cys Ile Gln Ser Gly Pro Gly Cys Ser Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Glu Pro Asp Ser Leu Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Leu Lys Gly Cys Pro Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Arg Ser Ile Ala Asn Pro Glu Phe Asp Gln Arg Gly Gln Arg Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Asn 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Gln Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Ala Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Ile 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Met Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ser Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Asp Asp Ser Ser Asn Val 
            340                 345                 350         


Val Gln Leu Ile Lys Asn Ala Tyr Tyr Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Ala Ser Ser Ile Gly Lys Ser Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Asn Pro Val Thr Phe Gln Val Lys Val Met 
                405                 410                 415     


Ala Ser Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Gln Val Arg Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Glu Gln Ser Leu Cys Gly Gly Lys Gly Val 
    450                 455                 460                 


Met Glu Cys Gly Ile Cys Arg Cys Glu Ser Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Arg Asn 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Val Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Glu 
        515                 520                 525             


Ile Phe Gly Gln Tyr Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Ser Gln Val Cys Gly Gly Ser Asp Arg Gly Ser Cys Asn Cys Gly 
545                 550                 555                 560 


Lys Cys Ser Cys Lys Pro Gly Tyr Glu Gly Ser Ala Cys Gln Cys Gln 
                565                 570                 575     


Arg Ser Thr Thr Gly Cys Leu Asn Ala Arg Leu Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly His Cys Gln Cys Asn Arg Cys Ile Cys Asp Glu Gly Tyr Gln 
        595                 600                 605             


Pro Pro Met Cys Glu Asp Cys Pro Ser Cys Gly Ser His Cys Arg Asp 
    610                 615                 620                 


Asn His Thr Ser Cys Ala Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe 
625                 630                 635                 640 


Glu Lys Asn Cys Ser Val Gln Cys Ala Gly Met Thr Leu Gln Thr Ile 
                645                 650                 655     


Pro Leu Lys Lys Lys Pro Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Ile Thr Tyr Thr Leu Gln Gln Lys Asp Gly Arg Asn Ile Tyr Asn Ile 
        675                 680                 685             


His Val Glu Asp Ser Leu Glu Cys Val Lys Gly Pro Asn Val Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Val Gly Val Val Leu Ile Gly Val Leu Leu 
705                 710                 715                 720 


Leu Val Ile Trp Lys Ala Leu Thr His Leu Thr Asp Leu Arg Glu Tyr 
                725                 730                 735     


Arg Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  21
<211>  3161
<212>  DNA
<213>  Rattus norvegicus

<400>  21
caccaccaca gagccagctg gtgagaagca ggcagagaca tctccagtca gtcagattca       60

cggattggag gcttcctggg accaagaggg gtacttgacc acctgagcca gcccccccac      120

atccctccct gaggtagctg agtgacatct gtgctggccc tctctgatcc tcgtaccctg      180

tggcagcaag cctgcaagga ggaactcctt gggtgatcag cctggagtca tctggccctt      240

ctctccacag gacatgctgg gcccacacac actgctactc atcctagctg gactactctt      300

cctgggatct gccctgtccg aggaatgcac caagtacaaa gtcagcaact gccgggactg      360

tatccagtcg gggcctggct gctcgtggtg ccagaagctg aacttcaccg gaccagggga      420

gcctgactcc ttgcgctgtg acacgcgggc acagctgctc ctcaagggtt gcccagccga      480

tgatataatg gaccccaaga gctttgctga tctccacccc caatatcagg tgcaacggag      540

tcaactgtct ccacaaaaag tgacccttaa cttgcgacca gggcaggctg ctgcattcaa      600

tgtgactttc cgacgggcca agggctaccc cattgatctg tactacctca tggacctctc      660

ctactctatg ctcgatgacc tgaacaatgt caagaagttg ggtggtgatt tgctgcaggc      720

cctcaacgag atcacagagt ccggccgcat cggcttcggg tccttcgtgg acaagacggt      780

gctgcctttt gtcaacaccc atcccgagaa gctgaggaac ccatgcccca acaaggagaa      840

agcctgccag cctccgtttg cctttcgcca cgtgctcaag ctaaccgaca actccaacca      900

gtttcagaca gaggtcggca agcaactgat ttccggaaac ctggacgccc ctgagggcgg      960

gctggatgcc ataatgcaag tggctgcctg tccggaggaa attggctggc gcaatgtcac     1020

gaggctgctg gtgtttgcca cagacgacgg cttccacttt gccggtgatg ggaaactggg     1080

tgccatcctg acccccaacg atggccgctg ccacctggag gataacatgt acaagaggag     1140

caatgagttc gactacccgt cagtgggcca gctggcccac aaactttccg agagcaacat     1200

ccagcccatc tttgcagtga caaagaagat ggtgaaaacc tatgagaaac tgacagagat     1260

tatccccaag tcagcggtgg gcgagctgtc tgacgattcc agtaacgtag tccagcttat     1320

caagaaagcc tactacaaac tctcctctag agtcttcctg gaccacacca ccatcccgga     1380

caccctgaaa gtcacctatg actccttctg taataacaga gtatcgagta taggcaaatc     1440

ccgaggggac tgtgacggtg tgcagatcaa caacccggtc accttccagg taaaggtcac     1500

ggcttcggag tgtatccagg agcagtcctt tgtcatccgg gcgctgggct tcaccgacac     1560

agtgacggta caggtccatc cccagtgcga gtgccagtgc cgggaccaga gtcggatgag     1620

gaatctctgt ggaggcaagg gagtcatgga gtgtggcatc tgcaggtgtg agtctggcta     1680

cattgggaaa aactgtgagt gtcagacgca gggccggagc agccaggagc tggaggggaa     1740

ctgccggaag gacaatagtt ccattgtgtg ctcggggctg ggggactgca tctgcgggca     1800

gtgcgtgtgc cacacgagtg acatccccaa caaagtgatc tttgggcaat actgcgagtg     1860

tgacaacttc aactgtgaga gatatgatgg ccaagtctgc ggtggcctaa agagaggctc     1920

ctgctcctgt ggccagtgta attgcaagga gggtttcgag ggttctgctt gccagtgtca     1980

gaggtctacc acgggctgtc tgaacgcacg gctggtggag tgcagtggcc gtggccggtg     2040

ccaatgcaac agatgcatct gtgagaaagg ttaccagcca cctctgtgtg aagagtgtcc     2100

cggctgcccc ttgccctgca gcacctacgt cttctgtgcc gagtgcctga aatttgataa     2160

gggccccttt cagaagaatt gtagtgttca gtgtgccaat gtgacgctgc agactgtccc     2220

tttcaagaaa aagccctgca aggagaggga ctcggagggc tgctggataa cctacacttt     2280

gcagcagaag gacggaaacg cttacaacat ccatgtggac gacgatcgag agtgtgtgaa     2340

aggccccaac gtggctgcca tcataggggg cactgtggcc ggcgttgtac tgattggtgt     2400

cctcctcctg gtcatctgga aggctcttac ccacctgact gacctcaatg aatacagacg     2460

ctttgagaag gagaaactca agtcccagtg gaacaacgac aaccccctct tcaagagcgc     2520

cacgacaacg gtcatgaacc ctaagtttgc tgagagctag agaaggagtc agaggagacc     2580

cctccagacc atgcctcctc ccctctgcaa atagaatgta gcttacagct agccccagtg     2640

ctgccaagga tccaaaagcc tactttgttt ctttccgcca ttatatcaag gctgccaggg     2700

tttccacaga ctcatcttcc gacctataca atcttgccac agagcctgca gattgttccg     2760

gagtcccaag aggttccaca cacgttttcg tgcataaagg gaagacaggg gtctcagtaa     2820

aggtggcccc agcttattta tatttaaact tgttagcgta taaaactact attatattgt     2880

taacatcctg tccgttgtat tatatgtgag tgtaaaacta tatcccacat atatcagaat     2940

catgtgtgta aaaataataa agcttccatt cagggctgca gagatggctc agtggttaag     3000

agcactgact gctcttccag aggtcctgag ttcaattccc agcatccaca tggtggctca     3060

caaccatctg taatgggatc tgatgccctt gtctggtgtg gctgaagata gcaacagtgt     3120

actcacatac ataaaataaa taaagccttt taataaaaaa a                         3161


<210>  22
<211>  768
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Leu Gly Pro His Thr Leu Leu Leu Ile Leu Ala Gly Leu Leu Phe 
1               5                   10                  15      


Leu Gly Ser Ala Leu Ser Glu Glu Cys Thr Lys Tyr Lys Val Ser Asn 
            20                  25                  30          


Cys Arg Asp Cys Ile Gln Ser Gly Pro Gly Cys Ser Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Glu Pro Asp Ser Leu Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Leu Lys Gly Cys Pro Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Lys Ser Phe Ala Asp Leu His Pro Gln Tyr Gln Val Gln Arg Ser 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Asn Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Asn 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Gln Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Ala Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Ile 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Met Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ser Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Asp Asp Ser Ser Asn Val 
            340                 345                 350         


Val Gln Leu Ile Lys Lys Ala Tyr Tyr Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Thr Thr Ile Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Asn Asn Arg Val Ser Ser Ile Gly Lys Ser Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Asn Pro Val Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Ser Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Gln Val His Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Met Arg Asn Leu Cys Gly Gly Lys Gly Val 
    450                 455                 460                 


Met Glu Cys Gly Ile Cys Arg Cys Glu Ser Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Asn 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Val Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Ile Pro Asn Lys Val 
        515                 520                 525             


Ile Phe Gly Gln Tyr Cys Glu Cys Asp Asn Phe Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Leu Lys Arg Gly Ser Cys Ser Cys Gly 
545                 550                 555                 560 


Gln Cys Asn Cys Lys Glu Gly Phe Glu Gly Ser Ala Cys Gln Cys Gln 
                565                 570                 575     


Arg Ser Thr Thr Gly Cys Leu Asn Ala Arg Leu Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Gln Cys Asn Arg Cys Ile Cys Glu Lys Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Glu Glu Cys Pro Gly Cys Pro Leu Pro Cys Ser Thr 
    610                 615                 620                 


Tyr Val Phe Cys Ala Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Gln 
625                 630                 635                 640 


Lys Asn Cys Ser Val Gln Cys Ala Asn Val Thr Leu Gln Thr Val Pro 
                645                 650                 655     


Phe Lys Lys Lys Pro Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Ile 
            660                 665                 670         


Thr Tyr Thr Leu Gln Gln Lys Asp Gly Asn Ala Tyr Asn Ile His Val 
        675                 680                 685             


Asp Asp Asp Arg Glu Cys Val Lys Gly Pro Asn Val Ala Ala Ile Ile 
    690                 695                 700                 


Gly Gly Thr Val Ala Gly Val Val Leu Ile Gly Val Leu Leu Leu Val 
705                 710                 715                 720 


Ile Trp Lys Ala Leu Thr His Leu Thr Asp Leu Asn Glu Tyr Arg Arg 
                725                 730                 735     


Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro Leu 
            740                 745                 750         


Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu Ser 
        755                 760                 765             


<210>  23
<211>  2929
<212>  DNA
<213>  Sus scrofa

<400>  23
ggccttcgcc agcagggcct ctgcgggcgg gtgtcttccc agacgcgcac gagacccagc       60

ctgccaaagg gtggaactga agccccccag cccagccggg accccctgcg gaggtctcca      120

ggacatcaag caggacatgc tgtgccggtg ctccccgctg ctcctcctgg tgggcctgct      180

caccctccgg tccgccctct cccaggagtg tgccaagtac aaggtcagca cctgccggga      240

ctgcattgag tcgggacccg gctgtgcctg gtgccagaag ctgaacttct ctgggcaagg      300

ggagcccgac tccgtccgct gtgacacgcg ggagcagctg cttgcaaagg gctgtgtcgc      360

ggatgacatc gtggatccca ggagcctggc cgagacccag gaggaccagg cagggggcca      420

gaagcagctg tccccacaga aagtgacact ctacctgaga ccaggtcagg cggccacgtt      480

caacgtgacc ttccggcgcg ccaagggcta ccccatcgac ctgtactacc tgatggacct      540

gtcctactcc atgctcgacg acctcatcaa cgtgaagaag ctggggggcg acctgctcag      600

ggctctcaac gagatcaccg agtctggccg catcggcttt gggtctttcg tggacaagac      660

ggtgcttccc ttcgtcaaca cgcaccccga gaagctgcgg aacccctgcc ccaacaaaga      720

gaaggagtgc caggccccgt tcgccttccg acacgtgctc aagctcacgg acaactccaa      780

ccagttccag acggaggtcg ggaagcagct gatctcgggg aacctggacg cccccgaggg      840

cgggctggat gccatgatgc aggtggccgc gtgcccggag gagatcggct ggcgcaacgt      900

caccaggctg ctggtgttcg ccacggacga tggcttccac tttgcgggcg acgggaagct      960

gggcgccatc ctgaccccca atgacggccg ctgccacctg gaagacaact tatacaaaag     1020

cagcaatgaa ttcgactacc catcagtggg acagctggca cacaaactgg ccgaaagcaa     1080

catccagccc atctttgccg tgaccaagaa aatggtgaaa acgtatgaga agctcacaga     1140

catcatcccc aagtccgccg tcggggagct gtcggaggat tccagcaacg tcctggagct     1200

cattaagaac gcctacaata aactgtcctc cagagtgttt ttggatcaca acgccctccc     1260

tgacaccctg aaggtcacgt acgactcctt ctgcagcaac ggggtgtcgc aggtgaacca     1320

gcccagaggg gactgcgacg gcgtccagat caacgtcccg atcaccttcc aggtgaaggt     1380

caccgcctcc gagtgcatcc aggagcagtc gttcgtcatc cgggcgctgg gcttcaccga     1440

cacggtgacc gtgcgggtgc tcccccagtg tgagtgccgc tgcggggaca gcagcaagga     1500

gcgcacgctc tgcggcaaca agggctccat ggagtgcggg gtctgcaggt gcgatgccgg     1560

ctacatcggg aagcactgcg agtgccagac gcagggccgg agcagccagg agctggaagg     1620

aagctgccgc aaggacaaca gctccatcat ctgctcgggg ctgggcgact gcatctgcgg     1680

gcagtgcgtg tgccacacga gcgacgtgcc caacaagaag atttacggcc agttctgcga     1740

gtgtgacaac atgaactgcg agcgcttcga tggccaagtc tgcgggggcg agaagcgggg     1800

cctctgcttc tgcagcacct gcaggtgcca agaaggtttc gagggctcgg cgtgccagtg     1860

cctcaagtcc acgcagggct gcctcaacct gcagggcgtc gagtgcagcg gccgcggccg     1920

gtgccgctgc aacgtgtgcc agtgtgactt tggctaccag ccgcccctgt gcaccgactg     1980

ccccagctgc caggtgccct gcgcccgcta cgccaaatgc gccgagtgcc tgaagttcga     2040

caccggcccc ttcgccaaaa actgcagcgc ggagtgcggg accactaagc tgctgcccag     2100

ccggatgtcg ggccgcaagt gcaatgagcg ggactccgag ggctgctgga tgacctactt     2160

cctggtgcag cgcgacggcc gggacaacta cgacctgcac gtggaggaga cgcgcgagtg     2220

tgtgaaaggc cccaacatcg ccgccatcgt ggggggcacc gtggggggag tcgtgctcgt     2280

gggcatcttc ctgctggtca tctggaaggt cctgacccac ctgagtgacc tcagggagta     2340

caagcgcttc gagaaggaga agctcaagtc ccagtggaac aacgataacc cccttttcaa     2400

gagcgccacc acgacagtta tgaaccccaa gtttgctgag cgctaggggt gcttggtgaa     2460

gacaaggtct tctgctccgt ccagacgggg ccgcctcccc tccggcaggc tgaccgtgac     2520

cctgtctggc ggacccagct gacgtccccc cacccccgac cccctcaaca tcagctgaaa     2580

acctgctctt ttccctgcgc cccaaatgac ggatctgttc agatgcttca atggactcat     2640

cggaagggac aatctcccgc ttctgagagg tgtgacttct ggtagccact tgaaaaagga     2700

ctcgcttgtg tctcgtaagg tcagacacct gtcttccttt gtaaaaatta gcacagcagt     2760

cagatggatg gagattccga tttatttata tgtgaactta tagggaatag aattgcattc     2820

ctgtgattat gctgtttcca atcatgtgca cggaaaaaaa tcgaataaat ctgcagaggc     2880

tcgctggggg ctgggctctg cgccccatct cagctgtgcc cacactccc                 2929


<210>  24
<211>  769
<212>  PRT
<213>  Sus scrofa

<400>  24

Met Leu Cys Arg Cys Ser Pro Leu Leu Leu Leu Val Gly Leu Leu Thr 
1               5                   10                  15      


Leu Arg Ser Ala Leu Ser Gln Glu Cys Ala Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Ser Gly Gln Gly Glu Pro Asp Ser Val Arg Cys Asp Thr 
    50                  55                  60                  


Arg Glu Gln Leu Leu Ala Lys Gly Cys Val Ala Asp Asp Ile Val Asp 
65                  70                  75                  80  


Pro Arg Ser Leu Ala Glu Thr Gln Glu Asp Gln Ala Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Thr Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Ile 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Ala Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Asp Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Leu Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Gln Val Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Ser Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Gly Asp Ser Ser Lys Glu Arg Thr Leu Cys Gly Asn Lys Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys His 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Met Asn Cys Glu Arg Phe 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Ser 
545                 550                 555                 560 


Thr Cys Arg Cys Gln Glu Gly Phe Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Gln Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Phe Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Thr Asp Cys Pro Ser Cys Gln Val Pro Cys Ala Arg 
    610                 615                 620                 


Tyr Ala Lys Cys Ala Glu Cys Leu Lys Phe Asp Thr Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Glu Cys Gly Thr Thr Lys Leu Leu Pro Ser Arg 
                645                 650                 655     


Met Ser Gly Arg Lys Cys Asn Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Phe Leu Val Gln Arg Asp Gly Arg Asp Asn Tyr Asp Leu His 
        675                 680                 685             


Val Glu Glu Thr Arg Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Phe Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Val Leu Thr His Leu Ser Asp Leu Arg Glu Tyr Lys 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Arg 
    


<210>  25
<211>  2365
<212>  DNA
<213>  Pan troglodytes

<400>  25
ccaggagcac cgccgaggac tccagagcac caagggacat gctgggcctg cgccccccac       60

tgctcgccct ggtggggctg ctctccctcg ggtgcgtcct ctctcaggag tgcacgaagt      120

tcaaggtcag cagctgccgg gaatgcatcg agtcggggcc cggctgcacc tggtgccaga      180

agctgaactt cacagggccg ggggatcctg actccattcg ctgcgacacc cggccacagc      240

tgctcatgag gggctgtgcg gctgacgaca tcatggaccc caagagcctc gctgaaaccc      300

aggaagacca caatgggggc cagaagcagc tgtccccaca aaaagtgacg ctttacctgc      360

gaccaggcca ggcagcagcg ttcaacgtga ccttccggcg ggccaagggc taccccatcg      420

acctgtacta cctgatggac ctctcctact ccatgcttga tgacctcagg aatgtcaaga      480

agctgggggg cgacctgcta cgggccctca acgagatcac cgagtccggc cgcattggct      540

tcgggtcctt cgtggacaag accgtgctgc cgttcgtgaa cacgcaccct gataagctgc      600

gaaacccatg ccccaacaag gagaaggagt gccagccccc gtttgccttc aggcacgtgc      660

tgaagctgac caacaactcc agccagtttc agaccgaggt cgggaagcag ctgatttccg      720

gaaacctgga cgcacccgag ggtgggctgg atgccatgat gcaggtcgcc gcctgcccgg      780

aggaaatcgg ctggcgcaac gtcacgcggc tgctggtgtt tgccaccgat gacggcttcc      840

atttcgcggg cgacgggaag ctgggcgcca tcctgacccc caacgacggc cgctgtcacc      900

tggaggacaa cttgtacaag aggagcaacg aattcgacta cccatcggtg ggccagctgg      960

cgcacaagct ggctgaaaac aacatccagc ccatcttcgc ggtgaccagt aggatggtga     1020

agacctacga gaaactcacc gagatcatcc ccaagtcagc cgtgggggag ctgtctgagg     1080

actccagcaa tgtggtccat ctcattaaga atgcttacaa taaactctcc tccagggtct     1140

tcctggatca caacgccctc cccgacaccc tgaaagtcac ctatgactcc ttctgcagca     1200

atggagtgac gcacaggaac cagcccagag gtgactgtga tggcgtgcag atcaatgtcc     1260

cgatcacctt ccaggtgaag gtcacggcca cagagtgtat ccaggagcag tcatttgtca     1320

tccgggcgct gggcttcacg gacatagtga ccgtgcgggt ccttccccag tgcgagtgcc     1380

ggtgccggga ccagagcaga gaccgcagcc tctgccatgg caagggcttc ttggagtgcg     1440

gcatctgcag gtgtgacact ggctacattg ggaaaaactg tgagtgccag acacagggcc     1500

ggagcagcca ggagctggaa ggaagctgcc ggaaggacaa caactccatc atctgctcag     1560

ggctggggga ctgtgtctgc gggcagtgcc tgtgccacac cagcgacgtc cccggcaagc     1620

tgatatacgg gcagtactgc gagtgtgaca ccatcaactg tgagcgctac aacggccagg     1680

tctgcggtgg cccggggagg gggctctgct tctgcgggaa gtgccgctgc cacccgggct     1740

ttgagggctc agcgtgccag tgcgagagga ccaccgaggg ctgcctgaac ccgcggcgtg     1800

ttgagtgcag tggccgtggc cggtgccgct gcaacgtatg tgagtgccat tcaggctacc     1860

agctgcctct gtgccaggag tgccccggct gcccctcacc ctgtggcaag tacatctcct     1920

gtgccgagtg cctgaagttc gaaaagggcc cctttgggaa gaactgcagc gcggcgtgtc     1980

cgggcctgca gctgtcgaac aaccccgtga agggcaggac ctgcaaggag agggactcag     2040

agggctgctg ggtggcctac acgctggagc agcaggacgg gatggaccgc tacctcatct     2100

atgtggatga gagccgagag tgcgtggcag gccccaacat cgctgccatt gtcgggggca     2160

ccgtggcagg catcgtgctg atcggcatcc tcctgctggt catctggaag gctctgatcc     2220

acctgagcga cctccgggag tacaggcgct ttgagaagga gaagctcaag tcccagtgga     2280

acaatgataa tccccttttc aagagcgcca ccacgacggt catgaaccct aagtttgctg     2340

agagttagga gcacttggtg aagac                                           2365


<210>  26
<211>  769
<212>  PRT
<213>  Pan troglodytes

<400>  26

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Ser Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  27
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence that encodes the wildtype 25 aa peptide

<400>  27
atgctgcgcc agcgccccca gctgctgctc ctagcgggcc tgcttgccct ccagtccgtc       60

ctgtcccagg agtgc                                                        75


<210>  28
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25 mer peptide of the signal sequence from CD18 cattle/bison 
       protein

<400>  28

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys 
            20                  25  


<210>  29
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence water buffalo

<400>  29
atgctgcgcc agcgccccca gctgctgttc ctatcgggcc tgctcgccct ccagtccgtc       60

ctgtcccagg agtgc                                                        75


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing the CD18 signal sequence from water buffalo 
       protein

<400>  30

Met Leu Arg Gln Arg Pro Gln Leu Leu Phe Leu Ser Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys 
            20                  25  


<210>  31
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide of CD18 signal sequence from goat mRNA

<400>  31
atgctgcccc agcgccccca gctgctgctc ctagcaggcc tgctcgccct ccagtctgtc       60

ctgtcccagg agtgc                                                        75


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence goat protein

<400>  32

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys 
            20                  25  


<210>  33
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide of CD18 signal sequence sheep mRNA

<400>  33
atgctgcccc agcgccccca gctgctgctc ctagcgggcc tgctctccct ccagtccgtc       60

ctgtcccagg agtgc                                                        75


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence sheep protein

<400>  34

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys 
            20                  25  


<210>  35
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide containing CD 18 signal sequence deer m

<400>  35
atgctgcgcc agcgccccca gctgctgctc ctagcaggcc tgctagccct ccagtctgtc       60

cggtcccagg agtgc                                                        75


<210>  36
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide of CD18 signal peptide deer protein

<400>  36

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Arg Ser Gln Glu Cys 
            20                  25  


<210>  37
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence elk mRNA sequence

<400>  37
atgctgcgcc agcgccccca gctgctgctc ctagcgggcc tgctagccct ccagtctgtc       60

cagtcccagg agtgc                                                        75


<210>  38
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence elk protein

<400>  38

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Gln Ser Gln Glu Cys 
            20                  25  


<210>  39
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence human/chimp mRNA

<400>  39
atgctgggcc tgcgcccccc actgctcgcc ctggtggggc tgctctccct cgggtgcgtc       60

ctctctcagg agtgc                                                        75


<210>  40
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide contains CD18 signal sequence human/chimp protein

<400>  40

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys 
            20                  25  


<210>  41
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide of CD18 signal sequence mouse protein

<400>  41
atgctgggcc cacactcact gctgcttgcc ctagctggac tgttcttcct gggatctgct       60

gtgtcccagg aatgc                                                        75


<210>  42
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence mouse protein

<400>  42

Met Leu Gly Pro His Ser Leu Leu Leu Ala Leu Ala Gly Leu Phe Phe 
1               5                   10                  15      


Leu Gly Ser Ala Val Ser Gln Glu Cys 
            20                  25  


<210>  43
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence rat mRNA

<400>  43
atgctgggcc cacacacact gctactcatc ctagctggac tactcttcct gggatctgcc       60

ctgtccgagg aatgc                                                        75


<210>  44
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence rat protein

<400>  44

Met Leu Gly Pro His Thr Leu Leu Leu Ile Leu Ala Gly Leu Leu Phe 
1               5                   10                  15      


Leu Gly Ser Ala Leu Ser Glu Glu Cys 
            20                  25  


<210>  45
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence pig mRNA

<400>  45
atgctgtgcc ggtgctcccc gctgctcctc ctggtgggcc tgctcaccct ccggtccgcc       60

ctctcccagg agtgt                                                        75


<210>  46
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide containing CD18 signal sequence pig protein

<400>  46

Met Leu Cys Arg Cys Ser Pro Leu Leu Leu Leu Val Gly Leu Leu Thr 
1               5                   10                  15      


Leu Arg Ser Ala Leu Ser Gln Glu Cys 
            20                  25  


<210>  47
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence from human/chimp mRNA

<400>  47
atgctgggcc tgcgcccccc actgctcgcc ctggtggggc tgctctccct ccagtgcgtc       60

ctctctcagg agtgc                                                        75


<210>  48
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence from human/chimp protein

<400>  48

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gln Cys Val Leu Ser Gln Glu Cys 
            20                  25  


<210>  49
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence from mouse mRNA

<400>  49
atgctgggcc cacactcact gctgcttgcc ctagctggac tgttcttcct gcaatctgct       60

gtgtcccagg aatgc                                                        75


<210>  50
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence from mouse protein

<400>  50

Met Leu Gly Pro His Ser Leu Leu Leu Ala Leu Ala Gly Leu Phe Phe 
1               5                   10                  15      


Leu Gln Ser Ala Val Ser Gln Glu Cys 
            20                  25  


<210>  51
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence rat mRNA

<400>  51
atgctgggcc cacacacact gctactcatc ctagctggac tactcttcct gcaatctgcc       60

ctgtccgagg aatgc                                                        75


<210>  52
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence from rat protein

<400>  52

Met Leu Gly Pro His Thr Leu Leu Leu Ile Leu Ala Gly Leu Leu Phe 
1               5                   10                  15      


Leu Gln Ser Ala Leu Ser Glu Glu Cys 
            20                  25  


<210>  53
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 sig seq pig mRNA

<400>  53
atgctgtgcc ggtgctcccc gctgctcctc ctggtgggcc tgctcaccct ccaatccgcc       60

ctctcccagg agtgt                                                        75


<210>  54
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated peptide of CD18 signal sequence from pig protein

<400>  54

Met Leu Cys Arg Cys Ser Pro Leu Leu Leu Leu Val Gly Leu Leu Thr 
1               5                   10                  15      


Leu Gln Ser Ala Leu Ser Gln Glu Cys 
            20                  25  


<210>  55
<211>  2817
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein cow mRNA

<400>  55
gtcttcccag atccgcgaag caccagcctg gtgaagagca gagccgaagc ccctgccagt       60

ccagctggga cacccctgcc gaggtctcca gggcatccag gggacatgct gcgccagcgc      120

ccccagctgc tgctcctagc gggcctgctt gccctcgggt ccgtcctgtc ccaggagtgc      180

accaactaca aggtcagcac ctgccgggac tgcatcgagt cgggccccgg ctgcgcctgg      240

tgccagaaac tgaacttcac agggcaaggg gagcccgact ccattcgctg tgacacacga      300

gcggagctgc tgtcaaaggg ctgcccagct gatgacatca tggaacccaa gagcctcgct      360

gagacccggg acagccaggc gggcagtcgg aagcagctgt ccccacagga agtgacgctc      420

tacctgagac caggtcaggc agttgcgttc aacgtgacct tccggagggc caagggctac      480

cccatcgacc tgtactacct gatggacctc tcctactcca tggtggatga cctcgtcaac      540

gtcaagaagc tggggggtga cctgctccgg gccctcaatg gcatcaccga gtcgggccgc      600

attggtttcg ggtccttcgt ggacaagacg gtgctcccct tcgtcaacac gcaccccgag      660

aagctgcgga acccctgccc caacaaggag aaggagtgcc agcccccgtt cgccttcagg      720

cacgtgttga agctcactga caactccaaa cagttcgaga cagaagtcgg gaagcagctg      780

atctcgggga acctggacgc ccctgagggt gggctggacg ccatgatgca ggtggccgcg      840

tgcccggagg aaatcggctg gcgcaatgtc accaggctgc tggtgttcgc cacggacgat      900

gggttccact ttgcgggcga tggaaagctg ggtgccatcc tcacccccaa tgacggccgc      960

tgccacctgg aagacaacct gtacaaaagc agcaacgaat ttgactaccc atcggtgggc     1020

cagctggcac acaaactggc agaaagcaac atccagccca tctttgcagt aaccaagaag     1080

atggtgaaaa cgtacgagaa gctgacagag atcatcccca agtctgcagt cggggagctg     1140

tctgaagatt ccaggaacgt ggtggagctt atcaagaatg cctacaataa actgtcctcc     1200

agagtcttcc tggatcacag caccctccct gacaccctga aagtcaccta cgactccttc     1260

tgcagtaacg ggaaatcgca ggtggaccag cccagagggg actgcgacgg cgtccagatc     1320

aacgtcccga tcaccttcca ggtgaaggtc acagccaccg agtgcatcca gcagcagtcc     1380

ttcaccatcc gggcgctggg cttcacggac acggtgaccg tgcgggtcct cccccagtgc     1440

gagtgccaat gccgggacgc cagcagggac ggcagcatct gcggcggcag aggctcgatg     1500

gagtgcggcg tctgcaggtg tgacgccggc tacatcggga agaactgcga gtgccagacg     1560

cagggccgga gcagccagga gctggagggc agctgccgca aggacaacag ctccatcatc     1620

tgctcggggc tgggggactg catctgcggg cagtgcgtgt gccacacgag cgacgtgccc     1680

aacaagaaga tctacggcca gttctgcgag tgcgacaacg tcaactgcga acgctacgac     1740

ggccaagtct gcgggggcga aaagaggggg ctctgcttct gcggcacctg caggtgcgac     1800

gagcagtatg agggttcggc atgccagtgc ctcaagtcca ctcagggctg cctcaacttg     1860

gacggcgtcg agtgcagcgg ccgcggccga tgccgctgca atgtgtgcca gtgcgacccc     1920

ggctaccagc cgcccctgtg cagcgagtgc ccgggctgcc ccgtgccctg tgcgggcttc     1980

gccccctgca cagagtgcct gaagttcgac aagggcccct tcgccaagaa ctgcagcgca     2040

gcgtgcgggc agacgaagct gctgtccagc ccggtgcccg gccgcaagtg caaggagcgc     2100

gactccgagg gctgctggat gacctacacc ctggtgcagc gcgacgggcg ggacagatac     2160

gacgtgcacg tggacgacat gctcgagtgt gtgaagggcc ccaacatcgc tgccatcgtg     2220

gggggcaccg tggggggcgt cgtgctcgtc ggcatcctcc tgctggtcat ctggaaggcc     2280

ctgacacacc tgagcgacct cagggagtac catcgctttg agaaggagaa gctcaagtcc     2340

cagtggaaca acgataaccc tcttttcaag agtgccacca cgacagtcat gaaccctaag     2400

tttgccgaga gttaggggtg cccggtgaag acaaggcctt ctgcaccacc cagatgggaa     2460

caccccctct ccacgtcccc tccagcaggc tgaccgtgac cccgctgcct cgtggacgtg     2520

gctgacaact tcaccgttaa ccaaaaatgc actgcttttt ctgccccaga atgatgggcg     2580

tggccaggtt attctatggg ctcatggtaa gggccagcct accccttctg atatgaatga     2640

cttttgatag caagtcagag aaggaattgc ctacattttg tatggttaca cacaggtcct     2700

ttgtaaaaat tagtacagca gtctgatgaa gaattattta tgtgtgaact tctcagggta     2760

tgaagttaca tccccttggt tatgctgccc ccaatcaata aaaaaaaaaa aatcaat        2817


<210>  56
<211>  2315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein water buffalo mRNA

<400>  56
atgctgcgcc agcgccccca gctgctgttc ctatcgggcc tgctcgccct cgggtccgtc       60

ctgtcccagg agtgcaccaa gtacaaggtc agcacctgcc gggactgcat cgagtctggc      120

cccggctgcg cctggtgcca gaaactgaac ttcacagggc aaggggagcc tgactccctt      180

cgctgtgaca cacgggcgga gctgctgtca aagggctgcc cagctgatga catcatggaa      240

cccaagagcc ttgctgagac ccgggacagc caggcggaca gacagaagca gctgtcccca      300

caggaagtga cgctctacct gagaccaggt caggcagctg cgttcaacgt gaccttccgg      360

agggccaagg gctaccccat cgacctgtac tacctgatgg acctctccta ctccatggtg      420

gacgacctca tcaacgtcaa gaagctgggg ggtgacctgc tccgggccct caacgacatc      480

accgagtcgg gccgcattgg tttcgggtcc ttcgtggaca agacggtgct cccattcgtc      540

aacacgcacc ccgagaagct gcggaacccc tgccccaaca aggagaagga gtgccagccc      600

ccgttcgcct tcaggcacgt gttgaagctc accgacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc ggggaacctg gacgcccctg agggtgggct ggacgccatg      720

atgcaggtgg ctgcgtgccc ggaggaaatc ggctggcgca atgtcaccag gctgctggtg      780

tttgccacag acgatgggtt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaatgacg gccgctgcca cctggaagac aacctgtaca aaagcggcaa cgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttt      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cagagatcat ccccaagtct     1020

gcagtcgggg agctgtctga agattccaag aacgtggtgg agcttatcaa gaatgcctac     1080

aataaactgt cctccagagt cttcctggat cacagcaccc tccctgacac cctgaaagtc     1140

acctacgact ccttctgcag taacagggta tcgcaggtgg accagcccag aggggactgc     1200

gacggcgttc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccagcagc agtccttcac catccgggcg ctgggcttca cggacacggt gaccgtgcgg     1320

gtcctccccc agtgcgagtg ccaatgccgg gacgccagca gggacggcag catctgcggc     1380

ggcagaggct cgatggagtg cggcgtctgc aagtgtgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcaggg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aatagctcca tcatctgctc ggggctgggg gactgtatct gcgggcagtg cgtgtgccac     1560

acgagcgacg tgcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgaacgct acgacggcca agtctgcggg ggcgaaaaga gggggctctg cttctgcggc     1680

acctgcaggt gcgacgagca gtatgagggt tcggcatgcc agtgcctcaa gtccactcag     1740

ggctgcctca acttggacgg cgtcgagtgc agcggccgcg gccgatgccg ctgcaatgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcagcg agtgcccggg ctgccccgtg     1860

ccctgtgcgg gcttcgcccc ctgcacagag tgcctgaagt tcgacaaggg ccccttcgcc     1920

aagaactgca gcgcagcgtg cgggcagacg aagctgctgt ccagcccggt gcccggccgc     1980

aagtgcaagg agcgcgactc cgagggctgc tggatgacct acaccctggt gcagcgcgac     2040

gggcgggaca gatacgacgt gcacgtggac gacatgctcg agtgtgtgaa gggccccaac     2100

atcgctgcca tcgtgggggg caccgtgggg ggcgtcgtgc tcgtcggcat cctcctgctg     2160

gtcatctgga aggccctgac acacctgagc gacctcaggg agtaccatcg ctttgagaag     2220

gagaagctca agtcccagtg gaacaacgat aaccctcttt tcaagagtgc caccacgaca     2280

gtcatgaacc ctaagtttgc cgagagttag gggtg                                2315


<210>  57
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein water buffalo protein

<400>  57

Met Leu Arg Gln Arg Pro Gln Leu Leu Phe Leu Ser Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gly Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Leu Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Glu Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Asp Ser Gln Ala Asp Arg Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ile 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Gly Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Arg Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Gln Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Gly Ser Ile Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Lys Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asp Glu Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ser Glu Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  58
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein cattle protein

<400>  58

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gln Ser Val Leu Ser Gln Glu Cys Thr Asn Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Glu Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Asp Ser Gln Ala Gly Ser Arg Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Val Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Val 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Gly Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Arg Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Lys Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Gln Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Gly Ser Ile Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asp Glu Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ser Glu Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  59
<211>  2362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein bison mR

<400>  59
ggcatccagg ggacatgctg cgccagcgcc cccagctgct gctcctagcg ggcctgcttg       60

ccctcgggtc cgtcctgtcc caggagtgca ccaagtacaa ggtcagcacc tgccgggact      120

gcatcgagtc gggccctggc tgcgcctggt gccagaaact gaacttcaca gggcaagggg      180

agcccgactc cattcgctgt gacacacgag cggagctgct gtcaaagggc tgcccagctg      240

atgacatcat ggaacccaag agcctcgctg agaccctgga cagccaggcg ggcagtcgga      300

agcagctgtc cccacaggaa gtgacgctct acctgagacc aggtcaggca gctgcgttca      360

gcgtgacctt ccagagggcc aagggctacc ccatcgacct gtactacctg atggacctct      420

cctactccat ggtggatgac ctcgtcaatg tcaagaagct ggggggtgac ctgctccggg      480

ccctcaatgg catcaccgag tcgggccgca ttggtttcgg gtccttcgtg gacaagacgg      540

tgctcccctt cgtcaacacg caccccgaga agctgcggaa cccctgcccc aacaaggaga      600

aggagtgcca gcccccgttc gccttcaggc acgtgttgaa gctcactgac aactccaaac      660

agttcgagac agaagtcggg aagcagctga tctcggggaa cctggacgcc cctgagggtg      720

ggctggacgc catgatgcag gtggccgcgt gcccggagga aatcggctgg cgcaatgtca      780

ccaggctgct ggtgttcgcc acggacgatg ggttccactt tgcgggcgat ggaaagctgg      840

gtgccatcct cacccccaat gacggccgct gccacctgga agacaacctg tacaaaagca      900

gcaacgaatt tgactaccca tcggtgggcc agctggcaca caaactggca gaaagcaaca      960

tccagcccat ctttgcagta accaagaaga tggtgaaaac gtacgagaag ctgacagaga     1020

tcatccccaa gtctgcagtc ggggagctgt ctgaagattc caagaacgtg gtggagctta     1080

tcaagaatgc ctacaataaa ctgtcctcca gagtcttcct ggatcacagc accctccctg     1140

acaccctgaa agtcacctac gactccttct gcagtaacgg gaaatcgcag gtggaccagc     1200

ccagagggga ctgcgacggc gtccagatca acgtcccgat caccttccag gtgaaggtca     1260

cagccaccga gtgcatccag cagcagtcct tcaccatccg ggcgctgggc ttcacggaca     1320

cggtgaccgt gcgggtcctc ccccagtgcg agtgccaatg ccgggacgcc agcagggacg     1380

gcagcatctg cggcggcaga ggctcgatgg agtgcggcgt ctgcaggtgt gacgccggct     1440

acatcgggaa gaactgcgag tgccagacgc agggccggag cagccaggag ctggagggca     1500

gctgccgcaa ggacaacagc tccatcatct gctcggggct gggggactgc atctgcgggc     1560

agtgcgtgtg ccacacgagc gacgtgccca acaagaagat ctacggccag ttctgcgagt     1620

gcgacaacgt caactgcgaa cgctacgacg gccaagtctg cgggggcgaa aagagggggc     1680

tctgcttctg cggcacctgc aggtgcgacg agcagtatga gggttcggca tgccagtgcc     1740

tcaagtccac tcagggctgc ctcaacttgg acggcgtcga gtgcagcggc cgcggccgat     1800

gccgctgcaa tgtgtgccag tgcgaccccg gctaccagcc gcccctgtgc agcgagtgcc     1860

cgggctgccc cgtgccctgc gcgggcttcg ccccctgcac agagtgcctg aagttcgaca     1920

agggcccctt cgccaagaac tgcagcgcag cgtgcgggca gacgaagctg ctgtccagcc     1980

cggtgcccgg ccgcaagtgc aaggagcgcg actccgaggg ctgctggatg acctacaccc     2040

tggtgcagcg cgacgggcgg gacagatacg acgtgcacgt ggacgacatg ctcgagtgtg     2100

tgaagggccc caacatcgct gccatcgtgg ggggcaccgt ggggggcgtc gtgctcgtcg     2160

gcatcctcct gctggtcatc tggaaggccc tgacacacct gagcgacctc agggagtacc     2220

atcgcttcga gaaggagaag ctcaagtccc agtggaacaa cgataaccct cttttcaaga     2280

gtgccaccac gacagtcatg aaccctaagt ttgccgagag ttaggggtgc ccggtgaaga     2340

caaggccttc tgcaccaccc ag                                              2362


<210>  60
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein bison protein

<400>  60

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gly Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Glu Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Leu Asp Ser Gln Ala Gly Ser Arg Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Ser Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Val 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Gly Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Ser Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Lys Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Gln Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Gly Ser Ile Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asp Glu Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ser Glu Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  61
<211>  2507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein goat mRNA (Q-->G)

<400>  61
cagcctggtg aagagcagag ccgaagcccc tgccagtcca gctgggacac ccctgccgtg       60

gtctccaggg catccagggg acatgctgcc ccagcgcccc cagctgctgc tcctagcagg      120

cctgctcgcc ctcgggtctg tcctgtccca ggagtgcacc aagtacaaag tcagcacctg      180

ccgggactgc atcgagtcgg gccccggctg tgcctggtgc cagaaactga acttcacagg      240

gcaaggggag cccgactcca ctcgctgtga tacacgggcg cagctgctgt caaagggctg      300

cccagctgat gacatcatgg aacccaagag cctcgctgag acccggcaga gccaggcggg      360

caaacagaag cagctgtccc cagaggaagt gactctctac cttagaccag gtcaggcagc      420

tgcgttcaat gtgaccttcc agagggccaa gggctacccc atcgacctgt actatctgat      480

ggatctctcc tactccatgg tggacgacct cgccaacgtc aagaagctgg ggggtgacct      540

gctccgggcc ctcaatgaca tcaccgagtc gggccgcatc gggttcgggt ccttcgtgga      600

caagacagtg ctccccttcg tcaacacgca ccctgagaag ctgaggaacc cctgccccaa      660

caaggagaag cagtgccagc ccccgttcgc cttcaggcac gtgttgaagc tcaccgacaa      720

ctccaaacag ttcgagacag aagtcgggaa gcagctgatc tcggggaact tggacgcccc      780

tgagggtgga ctggacgcca tgatgcaagt ggccgcgtgc ccggaggaaa tcggctggcg      840

caatgtcacc aggctgctgg tgttcgccac agatgatggg ttccactttg cgggcgatgg      900

aaagctgggt gccatcctca cccccaacga cggccgctgc cacctggaag acaacctgta      960

caaaagcagc aacgaatttg actacccatc ggtgggccag ctggcacaca aactggcaga     1020

aagcaacatc cagcccatct tcgcggtaac caagaagatg gtgaaaacgt acgagaagct     1080

gacagaaatc atccccaagt ctgcagtcgg ggagctgtct gaagattcca agaacgtggt     1140

ggagcttatc aagagtgcct acaataaact gtcctccaga gtattcctgg atcacaacac     1200

cctccctgac accctgaaag tcgcctacga ctccttctgc agtaacgggg tgtcacaggt     1260

ggaccagccc agaggggact gtgacggcgt ccagatcaac gtcccgatca ccttccaggt     1320

gaaggtcaca gccaccgagt gcatccagga gcagtccttc accatccggg cgctgggctt     1380

cacggacacg gtgaccgtgc gggtccttcc ccagtgcgag tgccaatgcc gggacgccag     1440

cagggaccgc agcgtctgcg gtggcagagg ctcgatggag tgcggcgtct gcaggtgcga     1500

cgccggctac atcgggaaga actgcgagtg ccagacgcac ggccggagca gccaggagct     1560

ggagggcagc tgccgcaagg acaacagctc catcatctgc tcggggctag gggactgcat     1620

ctgcgggcag tgcgtgtgcc acacgagcga cgtgcccaac aagaagatct acggccagtt     1680

ctgcgagtgc gacaacgtca actgcgagcg ctacgacggc caagtctgcg ggggcgagaa     1740

gagggggctc tgcttctgcg gcacctgcag gtgcaacgag cagcatgagg gctcggcgtg     1800

ccagtgcctc aagtccactc agggctgcct caacctggac ggcgtcgagt gcagcggccg     1860

gggccgatgc cgctgcaacg tgtgccagtg cgaccccggc taccagccgc ccctgtgcat     1920

cgactgcccg ggctgccccg tgccctgcgc tggcttcgcc ccctgcaccg agtgcctgaa     1980

gttcgacaag ggccccttcg ccaagaactg cagcgcagcg tgcgggcaga cgaagctgct     2040

gtccagcccg gtgcccggcg gccgcaagtg caaggagcgc gactccgagg gctgctggat     2100

gacctacacc ctggtgcagc gcgacgggcg gaacagatac gacgtgcacg tggacgacat     2160

gctcgagtgt gtgaagggcc ccaacatcgc tgccatcgtg gggggcaccg tggggggagt     2220

tgtgctcgtc ggcatcctcc tgctggtcat ctggaaggcc ctgacacacc tgagcgacct     2280

cagggagtac catcgcttcg agaaggagaa gctcaagtcc cagtggaaca acgataaccc     2340

tcttttcaag agtgccacca cgacagtcat gaaccctaag tttgccgaga gttaggggtg     2400

cctggtgaag acaaggcctt ctgcaccacc cagacgggag cacgccctct cctcatcccc     2460

tccagcaggc tgaccgtgac cttgctgctt agtggacgca gctgatg                   2507


<210>  62
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein goat protein (Q-->G)

<400>  62

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gly Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Thr Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Gln Ser Gln Ala Gly Lys Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Glu Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ala 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Gln Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Ala Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr His Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Glu Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asn Glu Gln His Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ile Asp Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asn Arg Tyr Asp Val 
        675                 680                 685             


His Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  63
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein domestic sheep mRNA (Q-->G)

<400>  63
atgctgcccc agcgccccca gctgctgctc ctagcgggcc tgctctccct cgggtccgtc       60

ctgtcccagg agtgcaccaa gtacaaagtc agcacctgcc gggactgcat cgagtcgggc      120

cccggctgtg cctggtgtca gaaactgaac ttcacagggc aaggggagcc cgactccact      180

cgctgtgata cacgggcgca gctgctgtcg aagggctgcc cagctgatga catcatggaa      240

cccaagagcc tcgctgagac tcggcagagc caggcgggca aacagaagca gctgtcccca      300

gaggaagtga ccctctacct gagaccaggt caggcagcag cgttcaacgt gaccttccag      360

agggccaagg gctaccccat cgacctgtac tatctgatgg atctctccta ctccatggtg      420

gacgacctcg ccaacgtcaa gaagctgggg ggtgacctgc tccgggccct caatgacatc      480

accgagtcag gccgcattgg tttcgggtcc ttcgtggaca agacggtgct ccccttcgtc      540

aacacgcacc ccgagaagct gaggaacccc tgccccaaca aggagaagga gtgccagccg      600

ccgttcgcct tcaggcacgt gctgaagctc accgacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc ggggaacttg gacgcccctg agggtgggct ggacgccatg      720

atgcaagtgg ccgcgtgccc ggaggaaatt ggctggcgca atgtcaccag gctgctggtg      780

ttcgccacag acgatgggtt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaacgacg gccgctgcca cctggaagac aacctgtaca aaagcagcaa cgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttc      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cagaaatcat ccccaagtct     1020

gcagtcgggg agctgtctga agattccaag aacgtggtgg agcttatcaa gagtgcctac     1080

aataaactgt cctccagagt attcctggat cacaacaccc tccctgacac cctgaaagtc     1140

gcctacgact ccttctgcag taacggggtg tcgcaggtgg accagcccag aggggactgc     1200

gacggcgtcc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccaggagc agtccttcac catccgggcg ctgggcttca cggacacggt gaccgtgcgg     1320

gtccttcccc agtgcgagtg ccaatgccgg gaagccagca gggaccgcag cgtctgcggt     1380

ggcagaggct cgatggagtg cggcgtctgc aggtgcgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcacgg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aacagctcca tcatctgctc ggggctgggg gactgcatct gcgggcagtg cgtgtgccac     1560

acgagcgacg tgcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgagcgct acgacggcca agtctgcggg ggcgacaaga gggggctctg cttctgcggc     1680

acctgcaggt gcaacgacca gcatgagggc tcggcgtgcc agtgcctcaa gtccactcag     1740

ggctgcctca acctggacgg cgtcgagtgc agcggccgcg gccgatgccg ctgcaacgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcatcg actgcccggg ctgccccgtg     1860

ccctgcgctg gcttcgcccc ctgcaccgag tgcctgaagt tcgacaaggg tcccttcgcc     1920

aagaactgca gcgcagcgtg cgggcagacg aagctgctgt ccagcccggt gcccggcggc     1980

cgcaagtgca aggagcgtga ctccgagggc tgctggatga cctacaccct ggtgcagcgc     2040

gacgggcgga acagatacga cgtgcacgtg gacgacatgc tcgagtgtgt gaagggcccc     2100

aacatcgctg ccatcgtggg gggcaccgtg gggggagttg tgctcgtcgg catcctcctg     2160

ctggccatct ggaaggccct gacacacctg agcgacctca gggagtacca tcgcttcgag     2220

aaggagaagc tcaagtccca gtggaacaac gataaccctc ttttcaagag tgccaccacg     2280

acagtcatga accctaagtt tgccgagagt tag                                  2313


<210>  64
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein domestic sheep protein (Q-->G)

<400>  64

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Thr Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Gln Ser Gln Ala Gly Lys Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Glu Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ala 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Ala Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Glu Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr His Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Asn Asp Gln His Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asp Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ile Asp Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asn Arg Tyr Asp Val 
        675                 680                 685             


His Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Ala Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  65
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein wild sheep mRNA (Q-->G)

<400>  65
atgctgcccc agcgccccca gctgctgctc ctagcgggcc tgctctccct cgggtccgtc       60

ctgtcccagg agtgcaccaa gtacaaggtc agcacctgcc gggactgcat cgagtcgggc      120

cccagctgtg cctggtgcca gaaactgaac ttcacagggc aaggggagcc cgactccact      180

cgctgtgata caagggcgca gctgctgtcg aagggctgcc cagctgatga catcatggaa      240

cccaagagcc tcgctgagac ccggcagagc caggcgggca gacagaagca gctgtcccca      300

gaggaagtga ccctctacct gagaccaggt caggcagctg cgttcaacgt gaccttccag      360

agggccaagg gctaccccat cgacctgtac tatctgatgg atctctccta ctccatggtg      420

gacgacctcg ccaacgtcaa gaagctgggg ggtgacctgc tccgggccct caatgacatc      480

accgagtcgg gccgcattgg tttcgggtcc ttcgtggaca agacggtgct ccccttcgtc      540

aacacgcacc ccgagaagct gaggaacccc tgccccaaca aggagaagga gtgccagccg      600

ccgttcgcct tcaggcacgt gctgaagctc accgacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc ggggaacttg gacgcccctg agggtgggct ggacgccatg      720

atgcaagtgg ccgcgtgccc ggaggaaatt ggctggcgca atgtcaccag gctgctggtg      780

ttcgccacag acgatgggtt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaacgacg gccgctgcca cctggaagac aacctgtaca aaagcagcaa cgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttc      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cagaaatcat ccccaagtct     1020

gcagtcgggg agctgtctga agattccaag aacgtggtgg agcttatcaa gagtgcctac     1080

aataaactgt cctccagagt attcctggat cacaacaccc tccctgacac cctgaaagtc     1140

gcctacgact ccttctgcag taacagggtg tcacaggtgg accagcccag aggggactgt     1200

gacggcgtcc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccaggagc agtccttcac catccgggcg ctgggcttca cggacacggt gaccgtgcgg     1320

gtccttcccc agtgcgagtg ccaatgccgg gaagccagca gggaccgcgg cgtctgcggt     1380

ggcagaggct cgatggagtg cggcgtctgc aggtgcgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcacgg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aacagctcca tcatctgctc ggggctgggg gactgcatct gcgggcagtg cgtgtgccac     1560

acgagcgacg tgcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgagcgct acgacggcca agtctgcggg ggcgacaaga gggggctctg cttctgcggc     1680

gcctgcaggt gcaacgacca gtatgagggc tcggcgtgcc agtgcctcaa gtccactcag     1740

ggctgcctca acctgaacgg cgtcgagtgc agcggccgcg gccgatgccg ctgcaacgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcatcg actgcccggg ctgccccgtg     1860

ccctgcgctg gcttcgcccc ctgcaccgag tgcctgaagt tcgacaaggg tcccttcgcc     1920

aagaactgca gcgcagcgtg cgggcagacg aagctgctgt ccagcccggt gcccggcggc     1980

cgcaagtgca aggagcgtga ctccgagggc tgctggatga cctacaccct ggtgcagcgc     2040

gacgggcgga acagatacga cgtgcacgtg gacgacatgc tcgagtgtgt gaagggcccc     2100

aacatcgctg ccatcgtggg gggcaccgtg gggggagttg tgctcgtcgg catcctcctg     2160

ctggccatct ggaaggccct gacacacctg agcgacctca gggagtacca tcgcttcgag     2220

aaggagaagc tcaagtccca gtggaacaac gataaccctc ttttcaagag tgccaccacg     2280

acagtcatga accctaagtt tgccgagagt tag                                  2313


<210>  66
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein wild sheep protein (Q-->G)

<400>  66

Met Leu Pro Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Ser Val Leu Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Ser Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Thr Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Pro Ala Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Lys Ser Leu Ala Glu Thr Arg Gln Ser Gln Ala Gly Arg Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Glu Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Ala 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Asp Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Ala Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Arg Val Ser Gln Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Glu Ala Ser Arg Asp Arg Gly Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr His Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Ala Cys Arg Cys Asn Asp Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asn Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Ile Asp Cys Pro Gly Cys Pro Val Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Gln Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Val Pro Gly Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asn Arg Tyr Asp Val 
        675                 680                 685             


His Val Asp Asp Met Leu Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Ala Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  67
<211>  2310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein deer mRNA (q-->g)

<400>  67
atgctgcgcc agcgccccca gctgctgctc ctagcaggcc tgctagccct cgggtctgtc       60

cggtcccagg agtgcaccaa atacaaggtc agcacctgcc gggactgcat cgagtcgggc      120

cccggctgtg cctggtgcca gaagctgaac ttcacagggc aaggggagcc cgactccgct      180

cgctgtgaca cacgggcgca gctgctgtcc aagggctgtg ccactgatga catcatggaa      240

cccaggagcc tcgctgagac ccaggagagc caggcaggca gacagaagca gctgtcccca      300

caggaagtga cgctctacct gagaccaggt caggcagctg cgttcaacgt gactttccgg      360

agggccaaag gataccccat cgacctgtac tacctgatgg atctctccta ctccatggtg      420

gacgacctcg tcaacgtcaa gaagctgggg ggtgacctgc tccgggccct caacggcatc      480

actgagtcgg gccgcatcgg tttcgggtcc ttcgtggaca agacggtgct cccctttgtc      540

aacacgcacc ccgagaagct gcggaacccc tgccccaaca aggagaagca gtgccagccc      600

ccgttcgcct tcaggcacgt gctgaagctc accaacaact ccaaacagtt cgagacagaa      660

gtcgggaagc agctgatctc gggaaacctg gacgcccccg agggagggct ggacgccatg      720

atgcaggtgg ccgtgtgccc ggaggaaatc ggctggcgca atgtcaccag gctgctggtg      780

tttgccacgg atgatggctt ccactttgcg ggcgatggaa agctgggtgc catcctcacc      840

cccaacgacg gccgctgcca cctggaagac aacctgtaca aaagcagcaa tgaatttgac      900

tacccatcgg tgggccagct ggcacacaaa ctggcagaaa gcaacatcca gcccatcttt      960

gcggtaacca agaagatggt gaaaacgtac gagaagctga cggagatcat ccccaagtct     1020

gcagtcgggg agctgtctga agactccagg aacgtggtgg agcttatcaa gagtgcctac     1080

aacaaactgt cctccagagt cttcctggat cacaacaccc tccctgacac cctgaaagtc     1140

acctacgact ccttctgcag taacggggtg tcgaaggtgg accagcccag aggggactgc     1200

gacggcgtcc agatcaacgt cccgatcacc ttccaggtga aggtcacagc caccgagtgc     1260

atccaggagc agtccttcac catccgggcc ctgggcttta cggacacggt gaccgtgcgg     1320

gtcctccccc agtgcgagtg ccaatgccgg gacgcgagca gggaccgcag cgtctgcggt     1380

ggcagaggct cgatggagtg cggcgtctgc aggtgcgacg ccggctacat cgggaagaac     1440

tgcgagtgcc agacgcaggg ccggagcagc caggagctgg agggcagctg ccgcaaggac     1500

aacagctcca tcatctgctc ggggctgggg gactgcatct gcgggcagtg cgtgtgccac     1560

acgagcgacg ttcccaacaa gaagatctac ggccagttct gcgagtgcga caacgtcaac     1620

tgcgagcgct acgacggcca agtctgcggg ggcgacaaga gggggctctg cttctgcggc     1680

acctgcaggt gccaggacca gtacgagggc tcggcgtgcc agtgcctcaa gtccacgcag     1740

ggctgcctca acctgaacgg cgtcgagtgc agcggccgcg gccggtgccg ctgcaacgtg     1800

tgccagtgcg accccggcta ccagccgccc ctgtgcaaag agtgcccggg ctgccccgcg     1860

ccctgcgccg gctttgcctc ctgcaccgag tgcctgaagt tcgacaaggg ccccttcgcc     1920

aagaactgca gcgcagcttg cggggagacg aagctgctgt ccagcccgcc gcccggccgc     1980

aagtgcaagg agcgcgactc cgagggctgc tggatgacct acaccctggt gcagcgcgac     2040

gggcgggaca gatacgacgt gcacgtgaac gacacgcgcg agtgtgtaaa gggccccaac     2100

atcgctgcca ttgtgggggg caccgtggcg ggagttgtgc ttgtcggcat cctcctgctg     2160

gtcatctgga aggccctgac acacctgagc gacctcaggg agtaccatcg cttcgagaag     2220

gagaagctca agtcccagtg gaacaacgat aaccctcttt tcaagagtgc caccacgaca     2280

gtcatgaacc ctaagtttgc cgagagttag                                      2310


<210>  68
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein deer protein (Q-->G)

<400>  68

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gly Ser Val Arg Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ala Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Ala Thr Asp Asp Ile Met Glu 
65                  70                  75                  80  


Pro Arg Ser Leu Ala Glu Thr Gln Glu Ser Gln Ala Gly Arg Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp Leu Val 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Gly Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Gln Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Lys Gln Phe Glu Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Val Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Arg Asn Val 
            340                 345                 350         


Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Ser Lys Val Asp Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu Cys Gln 
        435                 440                 445             


Cys Arg Asp Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg Gly Ser 
    450                 455                 460                 


Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn Lys Lys 
        515                 520                 525             


Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Thr Cys Arg Cys Gln Asp Gln Tyr Glu Gly Ser Ala Cys Gln Cys Leu 
                565                 570                 575     


Lys Ser Thr Gln Gly Cys Leu Asn Leu Asn Gly Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly Tyr Gln 
        595                 600                 605             


Pro Pro Leu Cys Lys Glu Cys Pro Gly Cys Pro Ala Pro Cys Ala Gly 
    610                 615                 620                 


Phe Ala Ser Cys Thr Glu Cys Leu Lys Phe Asp Lys Gly Pro Phe Ala 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Gly Glu Thr Lys Leu Leu Ser Ser Pro 
                645                 650                 655     


Pro Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Met 
            660                 665                 670         


Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val His 
        675                 680                 685             


Val Asn Asp Thr Arg Glu Cys Val Lys Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Val Val Leu Val Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr His 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  69
<211>  2824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein elk mRNA (q-->g)

<400>  69
aagcaccagc ctggtgaaga gcagagccga agcccctgcc agtccagccg ggacgtccct       60

gccgaggtct ccagggcatc cagtgggaca tgctgcgcca gcgcccccag ctgctgctcc      120

tagcgggcct gctagccctc gggtctgtcc agtcccagga gtgcaccaag tacaaggtca      180

gcacctgccg ggactgcatc gagtcgggcc ccggctgtgc ctggtgccag aagctgaact      240

tcacagggca aggggagccc gactccgctc gctgtgacac acgggcgcag ctgctgtcaa      300

agggctgtgc cgctgatgac atcatggatc ccaggagcct cgctgagacc cgggagagcc      360

aggcgggcag acagaagcag aagcagctgt ccccacagga agtgacgctc tacctgagac      420

caggtcaggc agctgcgttt aacgtgactt tccagagggc caagggctac cccatcgacc      480

tgtactacct gatggacctc tcctactcca tggtggatga cctcgtcaac gtcaagaagc      540

tggggggtga cctgctccgg gccctcaacg acatcaccga gtcgggccgc atcggtttcg      600

ggtccttcgt ggacaagacg gtgctccctt tcgtcaacac gcaccccgag aagctgcgga      660

acccctgccc caacaaggag aagcagtgcc agcccccgtt cgccttcagg cacgtgctga      720

agctcaccga caactccaaa cagttcgaga cagaagtcgg gaagcagctg atctcgggga      780

acctggacgc ccccgaggga gggctggacg ccatgatgca ggtggccgcg tgcccggagg      840

aaatcggctg gcgcaatgtc accaggttgc tggtgtttgc cacggatgat ggcttccact      900

ttgcgggcga tggaaagctg ggtgccatcc tcacccccaa cgacggccgc tgccacctgg      960

aagacaacct gtacaaaagc agcaacgaat ttgactaccc atcggtgggc cagctggcac     1020

acaaactggc agaaagcaac atccagccca tctttgcggt aaccaagaag atggtgaaaa     1080

cgtacgagaa gctgacggag atcatcccca agtctgcagt cggggagctg tctgaagatt     1140

ccaagaacgt ggtggagctt atcaagagtg cctacaataa actgtcctcc agagtcttcc     1200

tggatcacaa caccctccct gacaccctga aagtcaccta cgactccttc tgcagtaaag     1260

gggtgtcgaa ggtggaccag cccagagggg actgcgacgg cgtccagatc aacgtcccga     1320

tcaccttcca ggtgaaggtc acagccaccg agtgcatcca ggaacagtcc ttcaccatcc     1380

gggcgctggg ctttacggac acggtgaccg tgcgggtcct cccccagtgc gagtgccaat     1440

gccgggacgc gagcagggac cgcagcgtct gcggtggcag aggttcgatg gagtgcggcg     1500

tctgcaggtg cgacgccggc tacatcggga agaactgcga gtgccagacg cagggccgga     1560

gcagccagga gctggagggc agctgccgca aggacaacag ctccatcatc tgctcggggc     1620

tgggggactg catctgcggg cagtgcgtgt gccacacgag cgacgtgccc aacaagaaga     1680

tctacggcca gttctgcgag tgtgacaacg tcaactgcga acgctacgac ggccaagtct     1740

gcgggggcga caagaggggg ctctgcttct gcggcacctg caggtgccag gaccagtacg     1800

agggctcggc gtgccagtgc ctcaagtcca cgcagggctg cctcaacctg aacggcgtcg     1860

agtgcagcgg ccgcggccgg tgccgctgca acgtgtgcca gtgcgacccc ggctaccagc     1920

cgcccctgtg cttagagtgc cccggctgcc ccgcaccctg cgccggcttt gccccctgca     1980

ccgagtgcct gaagttcaag ggccccttcg ccaagaactg cagcgcagcg tgcggggaga     2040

cgaagctgct gtccaacccg ctgcccggcc gcaagtgcaa ggagcgcgac tcggagggct     2100

gctggatgac ctacaccctg gtgcagcgcg acgggcggga cagatacgac gtgcacgtga     2160

acgacacgcg cgagtgtgtg aagggcccca acatcgcggc cattgtgggg ggcaccgtgg     2220

ggggagttgt gctggttggc atcctcctgc tggtcatctg gaaggccctg acacacctga     2280

gcgacctcag ggagtaccat cgcttcgaga aggagaagct caagtcccag tggaacaatg     2340

ataaccctct tttcaagagt gccaccacga cagtcatgaa ccctaagttt gccgagagtt     2400

aggggtgcct ggtgaagaca aggccttctg caccacccag atgggaccac gccctctcca     2460

cgtcccctcc agcaggccga ccgtgaccct gctgccttgt ggacgtggct gatgatgctt     2520

gacaactcca ctgttaacca aaaatgcact gcttttcctg ccccagaatg atgggcgtga     2580

ccaaatgatc ctatgggctc atggtaaggg ccagcctccc ccttgatgtc aataactttt     2640

gctagcaagt cagaggagga attgcctaca ttttgtacgg ttacacacca gtcctttgta     2700

aaaattagca cagcagtctg atgaagaatt atttatatgt gaacttctca gggtatgaag     2760

ttatatcccc ttggttatgc tgccccccaa tcaataaaaa aaatcaagaa aaaaaaaaaa     2820

aaaa                                                                  2824


<210>  70
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CD18 protein elk protein (Q-->G)

<400>  70

Met Leu Arg Gln Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala 
1               5                   10                  15      


Leu Gly Ser Val Gln Ser Gln Glu Cys Thr Lys Tyr Lys Val Ser Thr 
            20                  25                  30          


Cys Arg Asp Cys Ile Glu Ser Gly Pro Gly Cys Ala Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Gln Gly Glu Pro Asp Ser Ala Arg Cys Asp Thr 
    50                  55                  60                  


Arg Ala Gln Leu Leu Ser Lys Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Arg Ser Leu Ala Glu Thr Arg Glu Ser Gln Ala Gly Arg Gln Lys 
                85                  90                  95      


Gln Lys Gln Leu Ser Pro Gln Glu Val Thr Leu Tyr Leu Arg Pro Gly 
            100                 105                 110         


Gln Ala Ala Ala Phe Asn Val Thr Phe Gln Arg Ala Lys Gly Tyr Pro 
        115                 120                 125             


Ile Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Val Asp Asp 
    130                 135                 140                 


Leu Val Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn 
145                 150                 155                 160 


Asp Ile Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys 
                165                 170                 175     


Thr Val Leu Pro Phe Val Asn Thr His Pro Glu Lys Leu Arg Asn Pro 
            180                 185                 190         


Cys Pro Asn Lys Glu Lys Gln Cys Gln Pro Pro Phe Ala Phe Arg His 
        195                 200                 205             


Val Leu Lys Leu Thr Asp Asn Ser Lys Gln Phe Glu Thr Glu Val Gly 
    210                 215                 220                 


Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp 
225                 230                 235                 240 


Ala Met Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn 
                245                 250                 255     


Val Thr Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala 
            260                 265                 270         


Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys 
        275                 280                 285             


His Leu Glu Asp Asn Leu Tyr Lys Ser Ser Asn Glu Phe Asp Tyr Pro 
    290                 295                 300                 


Ser Val Gly Gln Leu Ala His Lys Leu Ala Glu Ser Asn Ile Gln Pro 
305                 310                 315                 320 


Ile Phe Ala Val Thr Lys Lys Met Val Lys Thr Tyr Glu Lys Leu Thr 
                325                 330                 335     


Glu Ile Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Lys 
            340                 345                 350         


Asn Val Val Glu Leu Ile Lys Ser Ala Tyr Asn Lys Leu Ser Ser Arg 
        355                 360                 365             


Val Phe Leu Asp His Asn Thr Leu Pro Asp Thr Leu Lys Val Thr Tyr 
    370                 375                 380                 


Asp Ser Phe Cys Ser Lys Gly Val Ser Lys Val Asp Gln Pro Arg Gly 
385                 390                 395                 400 


Asp Cys Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys 
                405                 410                 415     


Val Thr Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Thr Ile Arg Ala 
            420                 425                 430         


Leu Gly Phe Thr Asp Thr Val Thr Val Arg Val Leu Pro Gln Cys Glu 
        435                 440                 445             


Cys Gln Cys Arg Asp Ala Ser Arg Asp Arg Ser Val Cys Gly Gly Arg 
    450                 455                 460                 


Gly Ser Met Glu Cys Gly Val Cys Arg Cys Asp Ala Gly Tyr Ile Gly 
465                 470                 475                 480 


Lys Asn Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu 
                485                 490                 495     


Gly Ser Cys Arg Lys Asp Asn Ser Ser Ile Ile Cys Ser Gly Leu Gly 
            500                 505                 510         


Asp Cys Ile Cys Gly Gln Cys Val Cys His Thr Ser Asp Val Pro Asn 
        515                 520                 525             


Lys Lys Ile Tyr Gly Gln Phe Cys Glu Cys Asp Asn Val Asn Cys Glu 
    530                 535                 540                 


Arg Tyr Asp Gly Gln Val Cys Gly Gly Asp Lys Arg Gly Leu Cys Phe 
545                 550                 555                 560 


Cys Gly Thr Cys Arg Cys Gln Asp Gln Tyr Glu Gly Ser Ala Cys Gln 
                565                 570                 575     


Cys Leu Lys Ser Thr Gln Gly Cys Leu Asn Leu Asn Gly Val Glu Cys 
            580                 585                 590         


Ser Gly Arg Gly Arg Cys Arg Cys Asn Val Cys Gln Cys Asp Pro Gly 
        595                 600                 605             


Tyr Gln Pro Pro Leu Cys Leu Glu Cys Pro Gly Cys Pro Ala Pro Cys 
    610                 615                 620                 


Ala Gly Phe Ala Pro Cys Thr Glu Cys Leu Lys Phe Lys Gly Pro Phe 
625                 630                 635                 640 


Ala Lys Asn Cys Ser Ala Ala Cys Gly Glu Thr Lys Leu Leu Ser Asn 
                645                 650                 655     


Pro Leu Pro Gly Arg Lys Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp 
            660                 665                 670         


Met Thr Tyr Thr Leu Val Gln Arg Asp Gly Arg Asp Arg Tyr Asp Val 
        675                 680                 685             


His Val Asn Asp Thr Arg Glu Cys Val Lys Gly Pro Asn Ile Ala Ala 
    690                 695                 700                 


Ile Val Gly Gly Thr Val Gly Gly Val Val Leu Val Gly Ile Leu Leu 
705                 710                 715                 720 


Leu Val Ile Trp Lys Ala Leu Thr His Leu Ser Asp Leu Arg Glu Tyr 
                725                 730                 735     


His Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn 
            740                 745                 750         


Pro Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala 
        755                 760                 765             


Glu Ser 
    770 


<210>  71
<211>  13
<212>  PRT
<213>  Bos taurus

<400>  71

Arg Pro Gln Leu Leu Leu Leu Ala Gly Leu Leu Ala Leu 
1               5                   10              


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  randomly scrambled sequence of CD18 bovine Amino Acids 5-17

<400>  72

Leu Arg Ala Leu Leu Pro Leu Gln Leu Leu Ala Gly Leu 
1               5                   10              


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M. haemolytica forward primer to examine representative colonies

<400>  73
agaggccaat ctgcaaacct c                                                 21


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M. haemolytica forward primer to examine representative colonies

<400>  74
gttcgtattg cccaacgccg                                                   20


